Oc1ccc(Nc2ncc(-c3ccncc3-c3ccccc3Cl)s2)cc1 CHEMBL3623439 IC50 0.3 nM
Cc1ccc(-c2cnccc2-c2cnc(Nc3ccc(O)cc3)s2)c(Cl)c1 CHEMBL5278261 IC50 0.3 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(Br)c4)[C@@H](C)C3)c12 CHEMBL570126 IC50 0.5 nM
CCNC(=O)Nc1ncc(-c2cc(-c3c(C)cc(OC)cc3C)nc(-c3cnccn3)n2)s1 CHEMBL2070615 IC50 1.0 nM
Cc1ccc(-c2cnccc2-c2cnc(NC(=O)C(C)C)s2)c(Cl)c1 CHEMBL3623442 IC50 1.0 nM
Cc1ccc(-c2cnccc2-c2cnc(C(=O)C(C)C)s2)c(Cl)c1 CHEMBL5275331 IC50 1.0 nM
CC(C)C(=O)Nc1ncc(C(=O)NCCN(Cc2ccccc2)C(=O)c2ccc(S(=O)(=O)Nc3ccccc3)cc2)s1 CHEMBL5169387 pIC50 1.445 nM
O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3218297 IC50 1.74 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(OC(=O)N(C)C)c4)[C@@H](C)C3)c12 CHEMBL570116 pIC50 1.995 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 2.44 nM
Clc1ccccc1-c1cnccc1-c1cnc(Nc2ccccc2)s1 CHEMBL3623438 IC50 3.0 nM
CC(C)C(=O)Nc1ncc(-c2ccncc2-c2ccccc2Cl)s1 CHEMBL3623441 IC50 3.0 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4ccc(F)c(Br)c4)[C@@H](C)C3)c12 CHEMBL565452 IC50 3.7 nM
C[C@@H](Nc1ncc(-c2ccncc2-c2ccccc2Cl)s1)c1ccccc1 CHEMBL3623437 IC50 4.0 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(NCCN(C)C)n2)s1 CHEMBL1258976 IC50 4.01 nM
CC(C)CNc1ncc(-c2ccncc2-c2ccccc2Cl)s1 CHEMBL3623435 IC50 5.0 nM
O=C(Nc1ncc(-c2cc(C(F)F)nn2-c2c(Cl)cccc2Cl)s1)C1CC1 CHEMBL3182065 IC50 5.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 6.0 nM
CC(C)C(=O)Nc1ncc(-c2cc(C(F)F)nn2-c2c(Cl)cccc2Cl)s1 CHEMBL2141887 pIC50 6.457 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4ccc(F)c(Br)c4)[C@@H](C)C3)c12 CHEMBL570820 IC50 6.6 nM
CCn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc21 CHEMBL3609326 pIC50 7.413 nM
C#CCOC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613609 IC50 7.6 nM
COCCN(C(=O)Nc1ccc(-c2ncnc3[nH]c(C)c(C)c23)cc1F)c1ccc(Cl)cc1 CHEMBL3410056 IC50 8.0 nM
COc1ccc(-c2cnccc2-c2cnc(NC(=O)C(C)C)s2)c(C(F)(F)F)c1 CHEMBL3623443 IC50 8.0 nM
COc1ccc(-c2cnccc2-c2cnc(C(=O)C(C)C)s2)c(C(F)(F)F)c1 CHEMBL5275515 IC50 8.0 nM
COCCN(C(=O)Nc1ccc(-c2ncnc3[nH]c(C)c(C)c23)c(F)c1)c1ccc(Cl)cc1 CHEMBL5289711 IC50 8.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 10.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2F)cc1 CHEMBL3629276 IC50 10.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2F)cn1 CHEMBL3629277 IC50 11.0 nM
Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(C(N)=O)nnc12 CHEMBL3586447 IC50 12.0 nM
Cc1c[nH]c2ncnc(N3CCC(CN)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356433 pIC50 12.3 nM
C=CC(=O)N1CCC(Oc2n[nH]c3ncc(-c4cn(-c5c(F)ccc(NS(=O)(=O)c6cccc(-c7ccccc7)c6)c5F)nn4)cc23)C1 CHEMBL5436237 IC50 12.3 nM
CCCNc1ncc(-c2ccncc2-c2ccc(OC)cc2C(F)(F)F)s1 CHEMBL3622874 IC50 13.0 nM
CCCNc1ncc(-c2ccncc2-c2ccccc2Cl)s1 CHEMBL3622867 IC50 15.0 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 15.85 nM
COC(=O)c1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613598 IC50 16.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(F)cc1C(F)(F)F CHEMBL2380834 IC50 18.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4cccc(C(=O)NC(C)C)c4)c(F)c3)c12 CHEMBL3407526 IC50 18.0 nM
COC(=O)c1cccc(NC(=O)C2(N)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613601 IC50 18.0 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3798142 IC50 18.0 nM
Cc1[nH]c2ncnc(-c3ccc(NC(=O)N(CCN(C)C)c4ccc(Cl)cc4)c(F)c3)c2c1C CHEMBL3410055 IC50 19.0 nM
Cc1c[nH]c2ncnc(N3CCC(CN(C)C)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3613599 IC50 19.0 nM
Cc1cc(NC(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2F)ccn1 CHEMBL3629278 IC50 19.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 19.95 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCN(C)C)c4ccc(Cl)cc4)cc3)c12 CHEMBL3410052 IC50 20.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(F)c34)CC2)c1 CHEMBL3613621 IC50 20.0 nM
CC(=O)Nc1ncc(-c2ccncc2-c2ccccc2Cl)s1 CHEMBL3623440 IC50 20.0 nM
CN(C)CC1(C(=O)Nc2cccc(OC(=O)N(C)C)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800259 IC50 20.0 nM
Cc1[nH]c2ncnc(-c3ccc(NC(=O)N(CCN)c4ccc(Cl)cc4)c(F)c3)c2c1C CHEMBL3410054 IC50 21.0 nM
Cc1[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(Cl)cc4)c(F)c3)c2c1C CHEMBL3410053 IC50 21.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCN)c4ccc(Cl)cc4)cc3)c12 CHEMBL3410050 IC50 21.0 nM
Cc1[nH]c2ncnc(N3CCC(CN(C)C)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c2c1C CHEMBL3613624 IC50 22.0 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(N)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3797469 IC50 22.0 nM
Cc1[nH]c2ncnc(N3CCC(CN)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c2c1C CHEMBL3799326 IC50 22.0 nM
CNC(=O)Nc1ncc(-c2cc(-c3c(C)cc(OC)cc3C)nc(-c3cnccn3)n2)s1 CHEMBL2070614 IC50 23.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]c(C)cc34)CC2)c1 CHEMBL3613622 IC50 23.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]ccc34)CC2)c1 CHEMBL3613610 IC50 23.0 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3797874 IC50 23.0 nM
COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(-c6ccccc6)c5)c4F)nn3)cc12 CHEMBL4450810 Kd 23.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(Cl)cc4)cc3)c12 CHEMBL3410042 IC50 25.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C#N)c34)CC2)c1 CHEMBL3613620 IC50 25.0 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 25.12 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]c(C)c(C)c34)CC2)c1 CHEMBL3613623 IC50 26.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3301612 Kd apparent 26.0 nM
COc1ccc(N(CCN)C(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)cc1 CHEMBL3410049 IC50 27.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613600 IC50 27.0 nM
COc1cc(Cl)c(-c2cc(-c3cnc(NC(C)=O)s3)nc(-c3cnccn3)n2)c(Cl)c1 CHEMBL2070619 IC50 30.0 nM
COC(=O)c1cccc(NC(=O)C2(N)CCN(c3ncnc4[nH]ccc34)CC2)c1 CHEMBL3613614 IC50 31.0 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 31.62 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 31.62 nM
COc1cc(-c2nn(C3CCC(N4CCN(C(C)=O)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1970879 pKi 31.62 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 31.62 nM
CNC(=O)Nc1ncc(-c2cc(-c3c(Cl)cc(OC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070618 IC50 32.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 32.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 33.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)cc1 CHEMBL3410032 IC50 35.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 CHEMBL2380845 IC50 36.0 nM
Cc1ccc(N(CCO)C(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)cc1 CHEMBL3410045 IC50 37.0 nM
COC(=O)c1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613602 IC50 37.0 nM
CCCNc1ncc(-c2ccncc2-c2ccccc2C(F)(F)F)s1 CHEMBL3622873 IC50 37.0 nM
CCCNc1ncc(-c2cc(-c3c(Cl)cc(OC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070497 IC50 38.0 nM
COC(=O)COc1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613603 IC50 38.0 nM
C[C@H](Nc1ncc(-c2ccncc2-c2ccccc2Cl)s1)c1ccccc1 CHEMBL3623436 IC50 40.0 nM
Cc1c[nH]c2ncnc(N3CCC(CN(C)C)(C(=O)Nc4cccc(C(=O)OC(C)C)c4)CC3)c12 CHEMBL3613607 IC50 41.0 nM
COC(=O)c1ccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)cc1 CHEMBL3613605 IC50 41.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4)cc3)c12 CHEMBL3410036 IC50 43.0 nM
Nc1ncnc2c1sc1cc(-c3ccc(NC=O)cc3)ccc12 CHEMBL3347511 IC50 44.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc2n1C1CCCC1 CHEMBL4063500 IC50 44.0 nM
COc1ccc(N(CCN(C)C)C(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)cc1 CHEMBL3410051 IC50 47.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(-c4nn[nH]n4)c3)ccc12 CHEMBL3347507 IC50 50.0 nM
CCC(C)OC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613608 IC50 50.0 nM
CCCOC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613606 IC50 50.0 nM
Cc1c2cc[nH]c(=O)c2c(C)c2c1[nH]c1ccc(OC(=O)c3ccccc3)cc12 CHEMBL5209373 IC50 50.0 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 50.12 nM
COc1ccc(N(CCO)C(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)cc1 CHEMBL3410048 IC50 53.0 nM
CCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355507 Kd 53.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(NC=O)c3)ccc12 CHEMBL3347658 IC50 55.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4cncnc4)c(F)c3)c12 CHEMBL3629279 IC50 55.0 nM
COC(=O)Cc1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613604 IC50 57.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4Cl)cc3)c12 CHEMBL3410040 IC50 58.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 pIC50 58.88 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4cccc(C(=O)NC(C)C)c4)c(C(F)(F)F)c3)c12 CHEMBL3410026 IC50 60.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4cccc(C(=O)NC(C)C)c4)cc3)c12 CHEMBL1951346 IC50 62.0 nM
C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 CHEMBL3116050 IC50 63.0 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 63.1 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 63.1 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(C)=O)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070611 IC50 64.0 nM
CCCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL4790618 Kd 64.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ccnc4[nH]ncc34)CC2)c1 CHEMBL3613612 IC50 65.0 nM
C#CCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL5206269 IC50 65.0 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(=O)NC)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070613 IC50 66.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4cccc(Cl)c4)cc3)c12 CHEMBL3410041 IC50 67.0 nM
COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5417444 IC50 67.3 nM
COc1cccc(NC(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)c1 CHEMBL3410031 IC50 75.0 nM
CC(C)NC(=O)Nc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347661 IC50 78.0 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 79.43 nM
COc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC CHEMBL1974664 pKi 79.43 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 79.43 nM
Cc1[nH]c2ncnc(-c3ccc(NC(=O)Nc4cccc(C(=O)NC(C)C)c4)cc3)c2c1C CHEMBL3410025 IC50 80.0 nM
Cc1cc2c(-c3ccc(NC(=O)Nc4cccc(C(=O)NC(C)C)c4)cc3)ncnc2[nH]1 CHEMBL3410024 IC50 80.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(C(=O)NCC(=O)N4CCOCC4)c3)ccc12 CHEMBL3347694 IC50 81.0 nM
CCCNc1ncc(-c2ccncc2-c2ccccc2C)s1 CHEMBL3622871 IC50 82.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4)c(F)c3)c12 CHEMBL3629280 IC50 85.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(F)cc4)cc3)c12 CHEMBL3410039 IC50 86.0 nM
COc1cc(C)c(-c2cc(-c3cnc(NC(C)=O)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070616 IC50 87.0 nM
CCNC(=O)Nc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347528 IC50 87.0 nM
CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL5184281 Kd 89.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4c(F)cccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4462318 Kd(free) 93.0 nM
CN1CCN(C(=O)Nc2cccc(-c3ccc4c(c3)sc3c(N)ncnc34)c2)CC1 CHEMBL3347683 IC50 95.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(NC(=O)N4CCCC4)c3)ccc12 CHEMBL3347669 IC50 95.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(C(=O)NCCc4cccnc4)c3)ccc12 CHEMBL3347513 IC50 97.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 100.0 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 100.0 nM
CN(Cc1cc(Cl)c(O)c2ncccc12)C1CCCCC1 CHEMBL1982413 pKi 100.0 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 100.0 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 100.0 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 100.0 nM
COc1cccc(N(CCO)C(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)c1 CHEMBL3410047 IC50 100.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4cccc(F)c4)cc3)c12 CHEMBL3410038 IC50 101.0 nM
CCCNc1ncc(-c2cc(-c3c(Cl)cc(OCCC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070498 IC50 115.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccccc2Cl)nn1 CHEMBL5181311 IC50 117.0 nM
NC(=O)c1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347689 IC50 120.0 nM
CCNc1ncc(-c2ccncc2-c2ccccc2Cl)s1 CHEMBL3623434 IC50 120.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 125.89 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 125.89 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 125.89 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(CC4CC4)nccn23)n1 CHEMBL1991800 pKi 125.89 nM
O=C(Nc1cnccn1)Nc1cccc2c(O)cccc12 CHEMBL1992371 pKi 125.89 nM
Nc1ncnc2c1sc1cc(-c3ccc(-c4nn[nH]n4)cc3)ccc12 CHEMBL3347682 IC50 127.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(CO)c3)ccc12 CHEMBL3347509 IC50 129.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4443828 Kd(free) 130.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4F)cc3)c12 CHEMBL3410037 IC50 132.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 133.0 nM
Cc1c[nH]c2ncnc(N3CCC(CCN(C)C)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356432 IC50 134.0 nM
C#CCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2cccc(Cl)c2)cc1 CHEMBL5192852 IC50 135.0 nM
CC(C)n1cc(Nc2ncc3ccc(=O)n(C(C)C)c3n2)cn1 CHEMBL5177053 IC50 137.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL3410028 IC50 142.0 nM
N#CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355509 pIC50 144.54 nM
CCCNc1ncc(-c2cc(-c3cc(OCCC4CCCCC4)ccc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070504 IC50 145.0 nM
NC(=O)Nc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347527 IC50 145.0 nM
COc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347688 IC50 149.0 nM
Cc1cccc(N(CCO)C(=O)Nc2ccc(-c3ncnc4[nH]cc(C)c34)cc2)c1 CHEMBL3410044 IC50 151.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)c(C#N)cc2F)n[nH]1 CHEMBL1774055 pIC50 151.36 nM
NC(=O)c1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347681 IC50 156.0 nM
C#CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL5190928 IC50 158.0 nM
O=C(Cc1cccs1)Nc1nc2ccccc2s1 CHEMBL1421720 pKi 158.49 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 158.49 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 158.49 nM
N#CC1=C(c2ccccc2)CC(c2ccc(Cl)cc2)C(C(=O)c2ccccc2)C1=O CHEMBL1978371 pKi 158.49 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 158.49 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 158.49 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 158.49 nM
Nc1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347666 IC50 159.0 nM
CCCNc1ncc(-c2cc(-c3c(Cl)cc(OC(CC)CC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070500 IC50 163.0 nM
Nc1ncnc2c1sc1cc(-c3ccc(CO)cc3)ccc12 CHEMBL3347692 IC50 163.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3C(N)=O)C2=O)COc2cc(Cl)ccc21 CHEMBL5202859 pIC50 169.82 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(=O)C(C)C)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070612 IC50 172.0 nM
CC(=O)c1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347510 IC50 172.0 nM
Cn1cc(-c2[nH]c3cc(NC(=O)[C@H](N)C4CCCCC4)cc4c3c2C=NNC4=O)cn1 CHEMBL3990456 pIC50 173.78 nM
CC(=O)Nc1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347512 IC50 181.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccccc2)nn1 CHEMBL5184302 IC50 186.0 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 194.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(C(=O)O)c3)ccc12 CHEMBL3347690 IC50 196.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(Cl)c3)ccc12 CHEMBL3347679 IC50 199.0 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 199.53 nM
CC(CCC(=O)O)(c1ccc(O)c(N)c1)c1ccc(O)c(N)c1 CHEMBL1975923 pKi 199.53 nM
N#Cc1ccc2nc(N)n(-c3nccs3)c2c1 CHEMBL1988805 pKi 199.53 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 199.53 nM
O=C(Nc1cccc(C2Nc3ccc4ccccc4c3C3C=CCC32)c1)c1ccc(F)cc1 CHEMBL1992042 pKi 199.53 nM
CC(=O)N1CCN(C2CCC(n3nc(-c4ccc(NC(=O)c5cc6ccccc6n5C)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1972584 pKi 199.53 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 pKi 199.53 nM
CCOC(=O)C1=c2sc(=Cc3ccco3)c(=O)n2C(N)=C(C#N)C1c1ccco1 CHEMBL1999112 pKi 199.53 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1987648 pKi 199.53 nM
O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1nc(C(=O)O)c(-c3ccc(CO)cc3)s1)CC2 CHEMBL1983980 pKi 199.53 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 199.53 nM
COCOc1cccc(OCOC)c1-c1ccc(NS(C)(=O)=O)cc1C(=O)OC CHEMBL2004025 pKi 199.53 nM
CC(C)NC(=O)c1cccc(NC(=O)Nc2ccc(-c3ncnc4[nH]ccc34)cc2)c1 CHEMBL1951344 IC50 201.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4nccs4)cc3)c12 CHEMBL3410033 IC50 203.0 nM
COc1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347680 IC50 204.0 nM
CCCNc1ncc(-c2cc(-c3ccc(OC4CCCC4)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070496 IC50 210.0 nM
CCCNc1ncc(-c2cc(-c3ccc(OC(CC)CC)cc3C)nc(-c3cnccn3)n2)s1 CHEMBL2070501 IC50 213.0 nM
COc1ccccc1-c1ccc2c(c1)sc1c(N)ncnc12 CHEMBL3347665 IC50 220.0 nM
CN1CCN(CCNC(=O)Nc2cccc(-c3ccc4c(c3)sc3c(N)ncnc34)c2)CC1 CHEMBL3347668 IC50 223.0 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(=O)OC)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070505 IC50 227.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(C(=O)NCCO)c3)ccc12 CHEMBL3347684 IC50 228.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(O)c3)ccc12 CHEMBL3347678 IC50 230.0 nM
Nc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347677 IC50 231.0 nM
CC(C)CNC(=O)Nc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347662 IC50 237.0 nM
COC(=O)c1cccc(NC(=O)C2(N)CCN(c3cc(NC(C)=O)ncn3)CC2)c1 CHEMBL3613618 IC50 239.0 nM
CS(=O)(=O)Nc1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347279 IC50 243.0 nM
CCCNc1ncc(-c2cc(-c3c(Cl)cc(OC4CCCC4)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070499 IC50 250.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(CCc1ccccc1)Cc1ccccc1 CHEMBL5179261 IC50 251.0 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4c(c3)OCO4)csc12 CHEMBL1993243 pKi 251.19 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 251.19 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12 CHEMBL1082440 pKi 251.19 nM
CN(C)c1ccc(-c2cc(-c3ccc([N+](=O)[O-])cc3)nc(NS(=O)(=O)c3ccc(N)cc3)n2)cc1 CHEMBL1980167 pKi 251.19 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(-c3ccccn3)n2)s1 CHEMBL1258633 IC50 252.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 255.0 nM
Cn1c2cc(-c3ccccc3)ccc2c2ncnc(N)c21 CHEMBL1836361 IC50 260.0 nM
Nc1ncnc2c1sc1cc(-c3ccccc3O)ccc12 CHEMBL3347657 IC50 260.0 nM
Nc1ncnc2c1sc1cc(-c3ccc(O)cc3)ccc12 CHEMBL3347667 IC50 267.0 nM
Nc1ncc(-c2ccncc2-c2ccccc2Cl)s1 CHEMBL3622875 IC50 270.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]ncc34)CC2)c1 CHEMBL3613611 IC50 282.0 nM
COc1ccccc1NC(=O)Nc1ccc(-c2ncnc3[nH]cc(C)c23)cc1 CHEMBL3410030 IC50 283.0 nM
COC(=O)Nc1ncc(-c2cc(-c3c(C)cc(OC)cc3C)nc(-c3cnccn3)n2)s1 CHEMBL2070617 IC50 284.0 nM
C[C@@H](NC(=O)c1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1)C(N)=O CHEMBL3347685 IC50 294.0 nM
Nc1ncnc2c1sc1cc(-c3ccccc3)ccc12 CHEMBL1836360 IC50 300.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccc(Cl)c(Cl)c2)nn1 CHEMBL5184275 IC50 305.0 nM
Nc1ccccc1-c1ccc2c(c1)sc1c(N)ncnc12 CHEMBL3347656 IC50 310.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL3410029 IC50 315.0 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 316.23 nM
Cc1ccc(C)c(NC(=O)c2cc(-c3ccco3)nc3ccccc23)c1 CHEMBL1984296 pKi 316.23 nM
Oc1ccc2nc(-c3ccc(Sc4ccc(-c5nc6ccc(O)cc6[nH]5)cc4)cc3)[nH]c2c1 CHEMBL2001149 pKi 316.23 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 316.23 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 316.23 nM
CCOC(=O)c1c(C)n(-c2ccc(I)cc2)c2c1cc(O)c1ccccc12 CHEMBL1970352 pKi 316.23 nM
COC(=O)c1c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c2c(N)ncnn2c1C CHEMBL1977041 pKi 316.23 nM
Cc1nc(Cn2cc(CN(Cc3ccccc3)C(=O)c3ccc(S(=O)(=O)Nc4ccccc4)cc3)nn2)cs1 CHEMBL5184915 IC50 325.0 nM
CCCNc1ncc(-c2cccnc2-c2ccccc2Cl)s1 CHEMBL3623445 IC50 327.0 nM
Cc1ccccc1N(CCO)C(=O)Nc1ccc(-c2ncnc3[nH]cc(C)c23)cc1 CHEMBL3410043 IC50 350.0 nM
NC1(C(=O)N[C@@H](CCO)c2ccc(Cl)cc2)CCN(c2nc[nH]c3nccc2-3)CC1 CHEMBL2325741 Kd apparent 357.0 nM
CCCNc1ncc(-c2cc(-c3ccc(OC(CC)CC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070495 IC50 359.0 nM
CS(=O)(=O)c1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347508 IC50 361.0 nM
CCOc1ccc(-c2cc(-c3cnc(NC(C)C)s3)nc(-c3cnccn3)n2)c(Cl)c1 CHEMBL2070491 IC50 368.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCN4CCCC4)c4ccccc4)cc3)c12 CHEMBL3410035 IC50 368.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347691 IC50 376.0 nM
Cn1c2cc(-c3cccc(C(N)=O)c3)ccc2c2ncnc(N)c21 CHEMBL3347515 IC50 379.0 nM
CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2cccc(Cl)c2)cc1 CHEMBL5186508 Kd 386.0 nM
CC(=O)Nc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347659 IC50 395.0 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 pKi 398.11 nM
CN(C)CC(=O)NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1991725 pKi 398.11 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1966514 pKi 398.11 nM
Cc1cc(Nc2cc(CN3CCOCC3)c3nc(C)c(Cc4ccc(Cl)cc4F)n3n2)n[nH]1 CHEMBL2107823 pIC50 398.11 nM
CCc1cccc(CC)c1NC(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1 CHEMBL363160 pIC50 407.38 nM
CCCCCOc1ccc(-c2cc(-c3cnc(NCCC)s3)nc(-c3cnccn3)n2)c(Cl)c1 CHEMBL2070494 IC50 444.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(CCc1cn(Cc2ccccc2)nn1)Cc1ccccc1 CHEMBL5202731 IC50 472.0 nM
CCOc1ccc(-c2cc(-c3cnc(NC(C)C)s3)nc(-c3ccccn3)n2)c(Cl)c1 CHEMBL2070489 IC50 485.0 nM
Cn1c2cc(-c3ccc(NC=O)cc3)ccc2c2ncnc(N)c21 CHEMBL3347529 IC50 498.0 nM
CCCNc1ncc(-c2ccncc2-c2cccc(Cl)c2)s1 CHEMBL3622868 IC50 500.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 501.19 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2ccc(OCC(=O)NCCO)cc2)n1 CHEMBL2006149 pKi 501.19 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 501.19 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 501.19 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 501.19 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 501.19 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 501.19 nM
ON=C(c1nc2ccccc2[nH]1)c1nc2ccccc2[nH]1 CHEMBL546797 pKi 501.19 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 501.19 nM
CN(C)c1ccc(N)c2ccccc12 CHEMBL1998253 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 501.19 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 501.19 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 501.19 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL1090356 pKi 501.19 nM
CS(=O)(=O)Nc1ccc(Nc2ccc3[nH]nc(N)c3c2)cc1 CHEMBL1988872 pKi 501.19 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 501.19 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 501.19 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 501.19 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccncc2)nn1 CHEMBL5190028 IC50 510.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 Kd apparent 535.0 nM
Cn1c2cc(-c3ccc(O)cc3)ccc2c2ncnc(N)c21 CHEMBL3347514 IC50 571.0 nM
CCCNc1ncc(-c2cnccc2-c2ccccc2Cl)s1 CHEMBL3623446 IC50 574.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 Kd apparent 616.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 620.0 nM
CCCNc1ncc(-c2ccncc2-c2ccc(Cl)cc2)s1 CHEMBL3622869 IC50 620.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 pKi 630.96 nM
Nc1ccc2cc(NCCc3ccccc3)cc(Nc3ncccn3)c2n1 CHEMBL550275 pKi 630.96 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 630.96 nM
OC1CCN(c2ncnc3[nH]cc(-c4ccccc4)c23)CC1 CHEMBL1973395 pKi 630.96 nM
COc1cc(Nc2nccc(Nc3cc(C4CCCCC4)no3)n2)cc(OC)c1OC CHEMBL1984711 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 630.96 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 630.96 nM
O=C1c2cc([N+](=O)[O-])ccc2-n2c1nc1cccc(Br)c1c2=O CHEMBL1976158 pKi 630.96 nM
CCN1CCN(Cc2ccc(-c3cc4c(N[C@H](C)c5ccccc5)ncnc4[nH]3)cc2)CC1 CHEMBL587723 Kd apparent 632.0 nM
Nc1ncnc2sc3c(c12)CCN(Cc1ccccc1)C3 CHEMBL1836391 IC50 660.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 680.0 nM
Nc1ncnc2c1sc1nc(-c3ccccc3)ccc12 CHEMBL3219028 IC50 700.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 701.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)Nc4cccc(C(=O)NC(C)C)c4)c(OCCN(C)C)c3)c12 CHEMBL3410027 IC50 710.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 720.0 nM
Nc1ncnc2c1sc1cc(-c3ccncc3)ccc12 CHEMBL3347526 IC50 732.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 770.0 nM
CCN(CC)CCNc1ccc(O)c2ccccc12 CHEMBL576113 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#Cc5cccnc5)cnc(N)c34)cc2)c1 CHEMBL1971947 pKi 794.33 nM
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2C1CCC(N2CCCC2)CC1 CHEMBL1965910 pKi 794.33 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL274064 pKi 794.33 nM
c1cc2[nH]ncc2cc1-c1cc(CN2CCCCC2)no1 CHEMBL1682360 pKi 794.33 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 794.33 nM
Nc1ccc2c(C(=O)O)n(-c3ccccc3)nc2c1 CHEMBL1974574 pKi 794.33 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 794.33 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 pKi 794.33 nM
CC(C)COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1984842 pKi 794.33 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 794.33 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 794.33 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(=O)O)s3)c2cc1OC CHEMBL474432 pKi 794.33 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 794.33 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 794.33 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(OCC(F)(F)F)nccn23)n1 CHEMBL2001957 pKi 794.33 nM
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL1879463 pKi 794.33 nM
O=CN(O)C(CS(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)c1ccc(O)cc1 CHEMBL1971227 pKi 794.33 nM
O=S(=O)(NCCNCC=Cc1ccc(Br)cc1)c1cccc2cnccc12 CHEMBL1987756 pKi 794.33 nM
Nc1ncnc2c1sc1cc(-c3cccnc3)ccc12 CHEMBL3347660 IC50 795.0 nM
COc1c(C=O)c(O)cc2c1C(=O)c1ccccc1C2=O CHEMBL212948 IC50 800.0 nM
N#Cc1ccc(-c2ccc3c(c2)sc2c(N)ncnc23)cc1 CHEMBL3347693 IC50 828.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 830.0 nM
CCCNc1ncc(-c2ccncc2-c2ccccc2)s1 CHEMBL3622870 IC50 850.0 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CCC(O)CC3)CC2)n1 CHEMBL2425628 Kd 870.0 nM
COc1cc(-c2nn(C3CCC(N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)OCc1ccccc1 CHEMBL5290037 IC50 900.0 nM
COc1ccccc1N(CCO)C(=O)Nc1ccc(-c2ncnc3[nH]cc(C)c23)cc1 CHEMBL3410046 IC50 913.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 940.0 nM
COC(=O)c1cccc(NC(=O)C2(N)CCN(c3cc(N)ncn3)CC2)c1 CHEMBL3613616 IC50 945.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 984.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 990.0 nM
CS(=O)(=O)Nc1ccccc1-c1ccc2c(c1)sc1c(N)ncnc12 CHEMBL3347663 IC50 998.0 nM
COc1cc(-c2ccc(=O)n(Cc3cccc(C)c3)n2)cc(OC)c1OC CHEMBL1982993 pKi 1000.0 nM
Nc1ncnc2sc(Br)c(-c3ccc(NC(=O)Cc4cccc(Cl)c4)cc3)c12 CHEMBL1980896 pKi 1000.0 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 1000.0 nM
COc1cccc(NC(=O)N2CCC(c3nc4c(C(N)=O)cccc4[nH]3)CC2)c1 CHEMBL1973363 pKi 1000.0 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL2005792 pKi 1000.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 1000.0 nM
Cc1n[nH]c2ncc(C#N)c(-c3ccccc3)c12 CHEMBL1965495 pKi 1000.0 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4sc(C)nc4c3)csc12 CHEMBL1968590 pKi 1000.0 nM
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O CHEMBL483158 pKi 1000.0 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1995832 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 1000.0 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 1000.0 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 1000.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 1000.0 nM
CC(N)C1CCC(C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL2002992 pKi 1000.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4c3CC(=O)N4)CC2)c1 CHEMBL3613613 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2cn3cccnc3n2)nn1 CHEMBL5180550 IC50 1000.0 nM