CN(C)C1(C(=O)Nc2cccc(-c3cccnc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800458 IC50 0.1 nM
CN(C)C1(C(=O)Nc2cccc(-c3ncno3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3799318 IC50 0.1 nM
CN(C)C1(C(=O)Nc2cccc(-c3ccccc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3797519 IC50 0.1 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3798142 IC50 0.2 nM
CN(C)CC1(C(=O)Nc2cccc(OC(=O)N(C)C)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800259 IC50 0.2 nM
CN(C)C1(C(=O)Nc2cccc(-n3cccc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3798662 IC50 0.2 nM
COC(=O)Cc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CC(F)(F)CC5)CC2)c1 CHEMBL3799270 IC50 0.2 nM
CN(C)C1(C(=O)Nc2cccc(-c3ccco3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3799925 IC50 0.3 nM
CN(C)C1(C(=O)Nc2cccc(-c3cccs3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800357 IC50 0.3 nM
CC(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3799236 IC50 0.4 nM
CN(C)C1(C(=O)Nc2cccc(NS(C)(=O)=O)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800330 IC50 0.4 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CC(F)(F)CC5)CC2)c1 CHEMBL3797658 IC50 0.4 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3797874 IC50 0.7 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(C(=O)NCCO)c4)[C@@H](C)C3)c12 CHEMBL571057 IC50 0.8 nM
COC(=O)Cc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3800144 IC50 0.8 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(Br)c4)[C@@H](C)C3)c12 CHEMBL570126 IC50 0.9 nM
CN(C)C1(C(=O)Nc2cccc(-c3cnco3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3799695 IC50 0.9 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCC5)CC2)c1 CHEMBL3797634 IC50 0.9 nM
Cc1c[nH]c2ncnc(N3CCC(Cc4c[nH]cn4)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356431 IC50 1.0 nM
Oc1ccc(Nc2ncc(-c3ccncc3-c3ccccc3Cl)s2)cc1 CHEMBL3623439 IC50 1.0 nM
CN(C)C(=O)Oc1cccc(NC(=O)C2(N)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3797469 IC50 1.0 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(C(C)(C)C)c4)[C@@H](C)C3)c12 CHEMBL570115 IC50 1.1 nM
C[C@H]1CN(c2ncnc3[nH]cc(Cl)c23)CCN1/C(=N/C#N)Nc1cccc(Br)c1 CHEMBL577194 IC50 1.2 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(C#N)c4)[C@@H](C)C3)c12 CHEMBL569861 IC50 1.2 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(OC(=O)N(C)C)c4)[C@@H](C)C3)c12 CHEMBL570116 IC50 1.2 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4ccccc4)[C@@H](C)C3)c12 CHEMBL3356064 IC50 1.2 nM
Cc1[nH]c2ncnc(N3CCC(CN(C)C)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c2c1C CHEMBL3613624 IC50 1.4 nM
Cc1[nH]c2ncnc(N3CCC(CN)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c2c1C CHEMBL3799326 IC50 1.4 nM
COC(=O)Cc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCC5)CC2)c1 CHEMBL3800261 IC50 1.4 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4ccc(F)c(Br)c4)[C@@H](C)C3)c12 CHEMBL565452 IC50 1.5 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613600 IC50 1.5 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(Cl)c4)[C@@H](C)C3)c12 CHEMBL570832 IC50 1.6 nM
Cc1c[nH]c2ncnc(N3CCC(CN)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356433 IC50 1.6 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]c(C)c(C)c34)CC2)c1 CHEMBL3613623 IC50 1.6 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(S(=O)(=O)NC(C)C)c4)[C@@H](C)C3)c12 CHEMBL566746 IC50 1.7 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(F)c4)[C@@H](C)C3)c12 CHEMBL584090 IC50 1.8 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(C(F)(F)F)c4)[C@@H](C)C3)c12 CHEMBL571947 IC50 1.9 nM
C=CCC1(C(=O)Nc2cccc(Cl)c2)CCN(c2ncnc3[nH]cc(C)c23)CC1 CHEMBL3356424 IC50 1.9 nM
COc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3800273 IC50 2.0 nM
CCCOC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613606 IC50 2.1 nM
C=CCC1(C(=O)Nc2cccc(OC(=O)N(C)C)c2)CCN(c2ncnc3[nH]cc(C)c23)CC1 CHEMBL3356426 IC50 2.2 nM
Cc1c[nH]c2ncnc(N3CCC(CN(C)C)(C(=O)Nc4cccc(C(=O)OC(C)C)c4)CC3)c12 CHEMBL3613607 IC50 2.2 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(Cl)c4)[C@@H](C)C3)c12 CHEMBL583464 IC50 2.3 nM
COCCOCC1(C(=O)Nc2cccc(OC(=O)N(C)C)c2)CCN(c2ncnc3[nH]cc(C)c23)CC1 CHEMBL3356430 IC50 2.7 nM
COc1cccc(NC(=O)N2CCN(c3ncnc4[nH]cc(C)c34)C[C@@H]2C)c1 CHEMBL3356063 IC50 2.7 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(F)c34)CC2)c1 CHEMBL3613621 IC50 2.8 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(S(=O)(=O)NCCO)c4)[C@@H](C)C3)c12 CHEMBL565453 IC50 2.9 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(C(=O)NCCO)c4)[C@@H](C)C3)c12 CHEMBL570821 IC50 3.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(C(=O)NC(CO)CO)c4)[C@@H](C)C3)c12 CHEMBL578615 IC50 3.0 nM
CCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355507 IC50 3.0 nM
Cc1ccc(-c2cnccc2-c2cnc(NC(=O)C(C)C)s2)c(Cl)c1 CHEMBL3623442 IC50 3.0 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(NCCN(C)C)n2)s1 CHEMBL1258976 IC50 3.05 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4ccc(F)c(Br)c4)[C@@H](C)C3)c12 CHEMBL570820 IC50 3.2 nM
Cc1c[nH]c2ncnc(N3CCC(C)(C(=O)Nc4cccc(C(C)(C)C)c4)CC3)c12 CHEMBL3356425 IC50 3.2 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(C(=O)NCCN(C)C)c4)[C@@H](C)C3)c12 CHEMBL571940 IC50 3.4 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(C(=O)NC(C)C)c4)[C@@H](C)C3)c12 CHEMBL585734 IC50 3.5 nM
CN(C)C1(C(=O)Nc2cccc(F)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3798406 IC50 3.7 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(Br)c4)[C@@H](C)C3)c12 CHEMBL571942 IC50 3.9 nM
Cc1c[nH]c2ncnc(N3C[C@H](C)N(/C(=N/C#N)Nc4cccc(Br)c4)C[C@H]3C)c12 CHEMBL570586 IC50 3.9 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C#N)c34)CC2)c1 CHEMBL3613620 IC50 4.0 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(Br)c4)[C@@H](C(C)C)C3)c12 CHEMBL570831 IC50 4.2 nM
Cc1cc2c(N3CCN(/C(=N/C#N)Nc4cccc(Br)c4)[C@@H](C)C3)ncnc2[nH]1 CHEMBL570830 IC50 4.2 nM
CN(C)C1(C(=O)Nc2ccccc2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800104 IC50 4.5 nM
CCC(C)OC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613608 IC50 4.6 nM
Cc1c[nH]c2ncnc(N3CCC(C)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356427 IC50 4.8 nM
CC(C)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3798086 IC50 4.8 nM
Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4cccc(OC(=O)N(C)C)c4)(N(C)C)CC3)c12 CHEMBL3356429 IC50 5.1 nM
CC(C)C(=O)Nc1ncc(C(=O)NCCN(Cc2ccccc2)C(=O)c2ccc(S(=O)(=O)Nc3ccccc3)cc2)s1 CHEMBL5169387 pIC50 5.495 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(C(=O)NC(C)C)c4)[C@@H](C)C3)c12 CHEMBL572170 IC50 5.5 nM
O=C(Nc1ncc(-c2cc(C(F)F)nn2-c2c(Cl)cccc2Cl)s1)C1CC1 CHEMBL3182065 IC50 6.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3C(N)=O)C2=O)COc2cc(Cl)ccc21 CHEMBL5202859 pIC50 6.31 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/S(C)(=O)=O)Nc4cccc(Br)c4)[C@@H](C)C3)c12 CHEMBL571706 IC50 6.8 nM
Cc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3800515 IC50 7.1 nM
N#CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355509 pIC50 7.244 nM
Cc1c[nH]c2ncnc(N3CCC(CCN(C)C)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356432 IC50 7.3 nM
COC(=O)c1cccc(NC(=O)C2(N)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613601 IC50 7.4 nM
COC(=O)c1ccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)cc1 CHEMBL3613605 IC50 7.7 nM
COc1cc(Cl)c(-c2cc(-c3cnc(NC(C)=O)s3)nc(-c3cnccn3)n2)c(Cl)c1 CHEMBL2070619 IC50 8.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]c(C)cc34)CC2)c1 CHEMBL3613622 IC50 8.0 nM
CC(C)C(=O)Nc1ncc(-c2cc(C(F)F)nn2-c2c(Cl)cccc2Cl)s1 CHEMBL2141887 IC50 8.0 nM
CC1CN(c2ncnc3[nH]ccc23)CCN1/C(=N/C#N)Nc1cccc(Br)c1 CHEMBL572371 IC50 8.1 nM
COC(=O)c1cccc(NC(=O)C2(N)CCN(c3ncnc4[nH]ccc34)CC2)c1 CHEMBL3613614 IC50 9.6 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)N[C@@H](C)c4ccccc4)[C@@H](C)C3)c12 CHEMBL3352853 IC50 9.9 nM
Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(Br)c4)CC3)c12 CHEMBL568484 IC50 11.0 nM
CN(C)C1(C(=O)Nc2cccc(CN3CCCCC3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3798226 IC50 11.0 nM
CNC(=O)Nc1ncc(-c2cc(-c3c(Cl)cc(OC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070618 IC50 12.0 nM
COC(=O)c1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613602 IC50 12.0 nM
CN(C)C1(C(=O)Nc2ccc(F)cc2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3799312 IC50 12.0 nM
CN(C)C1(C(=O)Nc2cccc(S(C)(=O)=O)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3797875 IC50 12.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]ccc34)CC2)c1 CHEMBL3613610 IC50 13.0 nM
COC(=O)c1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3797333 IC50 13.0 nM
CCn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc21 CHEMBL3609326 pIC50 13.49 nM
CCCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL4790618 pIC50 14.45 nM
Cc1c[nH]c2ncnc(N3CC4CCC(C3)N4C(=O)Nc3cccc(Br)c3)c12 CHEMBL584968 IC50 16.0 nM
CCCNc1ncc(-c2cc(-c3c(Cl)cc(OC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070497 IC50 16.0 nM
CNC(=O)Nc1ncc(-c2cc(-c3c(C)cc(OC)cc3C)nc(-c3cnccn3)n2)s1 CHEMBL2070614 IC50 16.0 nM
CN(C)C1(C(=O)Nc2ccc(C#N)cc2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3798698 IC50 17.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(CCO)Cc1ccccc1 CHEMBL3355508 IC50 19.0 nM
CN(Cc1ccc(CCC(=O)O)cc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355497 IC50 19.0 nM
C=CC(=O)N1CCC(Oc2n[nH]c3ncc(-c4cn(-c5c(F)ccc(NS(=O)(=O)c6cccc(-c7ccccc7)c6)c5F)nn4)cc23)C1 CHEMBL5436237 IC50 21.3 nM
O=S(=O)(Nc1ccccc1)c1ccc(-c2nccn2Cc2ccccc2)cc1 CHEMBL3355515 IC50 22.0 nM
Cc1cccc(NS(=O)(=O)c2ccc(C(=O)N(C)Cc3ccccc3)cc2)c1 CHEMBL3355491 IC50 22.0 nM
CN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2cccc(F)c2)cc1 CHEMBL3355489 IC50 22.0 nM
CN(C)c1ccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)cc1 CHEMBL3798729 IC50 22.0 nM
COC(=O)c1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 CHEMBL3797937 IC50 23.0 nM
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4)cc3)c12 CHEMBL3410036 IC50 24.0 nM
COc1cccc([C@@H](C)NC(=O)N2CCN(c3ccncc3F)C[C@H]2C)c1 CHEMBL5206259 IC50 25.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(OC(=O)N(C)C)c4)C(C(C)(C)C)C3)c12 CHEMBL3356419 IC50 26.0 nM
CN(C)C1(C(=O)Nc2ccc(OC(F)F)cc2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3797422 IC50 27.0 nM
CCCNc1ncc(-c2cc(-c3cc(OCCC4CCCCC4)ccc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070504 IC50 28.0 nM
CN(C)C1(C(=O)Nc2cccc(C(F)(F)F)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3797769 IC50 31.0 nM
CN(C)C1(C(=O)Nc2cccc(C#N)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3799054 IC50 32.0 nM
COCCOc1ccc(CN(C)C(=O)c2ccc(S(=O)(=O)Nc3ccccc3)cc2)cc1 CHEMBL3355496 IC50 34.0 nM
CN(CC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355501 IC50 36.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(Br)c4)[C@H](C)C3)c12 CHEMBL571502 IC50 37.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(Br)c4)CC3)c12 CHEMBL571280 IC50 38.0 nM
CCNC(=O)Nc1ncc(-c2cc(-c3c(C)cc(OC)cc3C)nc(-c3cnccn3)n2)s1 CHEMBL2070615 IC50 38.0 nM
CN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355482 IC50 39.0 nM
CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2cccc(Cl)c2)cc1 CHEMBL5186508 pIC50 39.81 nM
COc1ccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)cc1 CHEMBL3799167 IC50 41.0 nM
CN(C)c1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4438748 IC50 46.0 nM
COc1ccc(-c2cnccc2-c2cnc(NC(=O)C(C)C)s2)c(C(F)(F)F)c1 CHEMBL3623443 IC50 48.0 nM
CN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2cccc(Cl)c2)cc1 CHEMBL3355490 IC50 51.0 nM
CN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2F)cc1 CHEMBL3355483 IC50 52.0 nM
CCc1ccc(CN(C)C(=O)c2ccc(S(=O)(=O)Nc3ccccc3)cc2)cc1 CHEMBL3355495 IC50 53.0 nM
COc1cc(C)c(-c2cc(-c3cnc(NC(C)=O)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070616 IC50 59.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccccc2Cl)nn1 CHEMBL5181311 IC50 61.0 nM
CN(C)C1(C(=O)Nc2cccc(CN3CCOCC3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800555 IC50 62.0 nM
COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(-c6ccccc6)c5)c4F)nn3)cc12 CHEMBL4450810 Kd 63.0 nM
Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4cccc(Oc5ccccc5)c4)CC3)c12 CHEMBL570109 IC50 64.0 nM
C#CCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL5206269 IC50 65.0 nM
C#CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL5190928 IC50 67.0 nM
Cc1c2cc[nH]c(=O)c2c(C)c2c1[nH]c1ccc(OC(=O)c3ccccc3)cc12 CHEMBL5209373 IC50 75.0 nM
Cc1c[nH]c2ncnc(N3CC4CC3CN4/C(=N/C#N)Nc3cccc(Br)c3)c12 CHEMBL571261 IC50 76.0 nM
CN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccc(F)cc2)cc1 CHEMBL3355486 IC50 81.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 82.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 86.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccccc2)nn1 CHEMBL5184302 IC50 87.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 89.2 nM
Nc1ncnc2c1sc1cc(-c3cccc(-c4nn[nH]n4)c3)ccc12 CHEMBL3347507 IC50 90.0 nM
O=S(=O)(Nc1ccccc1)c1ccc(-c2nccnc2Cc2ccccc2)cc1 CHEMBL3355517 IC50 90.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccc(Cl)c(Cl)c2)nn1 CHEMBL5184275 IC50 90.0 nM
Cc1cccc(NC(=O)N2CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL571715 IC50 92.0 nM
CN(Cc1ccc(C(O)CO)cc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355498 IC50 92.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(CCc1ccccc1)Cc1ccccc1 CHEMBL5179261 IC50 92.0 nM
CN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)N(C)c2ccccc2)cc1 CHEMBL1711204 IC50 95.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3301612 Kd apparent 96.0 nM
O=S(=O)(Nc1ccccc1)c1ccc(-c2ncccc2Cc2ccccc2)cc1 CHEMBL3355516 IC50 100.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(NC(=O)N4CCCC4)c3)ccc12 CHEMBL3347669 IC50 103.0 nM
CN(C)C1(C(=O)Nc2ccccc2F)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3800529 IC50 105.0 nM
C[C@@H](c1ccccc1)N(C)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355505 IC50 110.0 nM
Cc1c[nH]c2ncnc(N3CC[C@H](C(=O)Nc4cccc(OC(=O)N(C)C)c4)[C@H](C)C3)c12 CHEMBL3356423 IC50 110.0 nM
Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4cccc(OC(=O)N(C)C)c4)[C@@H](C)C3)c12 CHEMBL5268230 IC50 110.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2ccncc2)nn1 CHEMBL5190028 IC50 118.0 nM
C[C@H](c1ccccc1)N(C)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355506 IC50 120.0 nM
Cc1ccccc1NS(=O)(=O)c1ccc(C(=O)N(C)Cc2ccccc2)cc1 CHEMBL3355484 IC50 120.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(CCc1cn(Cc2ccccc2)nn1)Cc1ccccc1 CHEMBL5202731 IC50 121.0 nM
CC(=O)Nc1ccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)cc1 CHEMBL3799817 IC50 122.0 nM
Cc1c[nH]c2ncnc(N3C[C@@H](C)N(C(=O)Nc4cccc(Br)c4)[C@@H](C)C3)c12 CHEMBL570819 IC50 133.0 nM
Nc1ncnc2c1sc1cc(-c3cccc(C(=O)NCCc4cccnc4)c3)ccc12 CHEMBL3347513 IC50 133.0 nM
Cc1c[nH]c2ncnc(N3CCC(O)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356428 IC50 138.0 nM
COc1cccc(NC(=O)N2CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL568706 IC50 140.0 nM
CCCNc1ncc(-c2cc(-c3c(Cl)cc(OCCC)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070498 IC50 141.0 nM
CN1CCN(C(=O)Nc2cccc(-c3ccc4c(c3)sc3c(N)ncnc34)c2)CC1 CHEMBL3347683 IC50 157.0 nM
CN(C)CCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL3355510 IC50 160.0 nM
C#CCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2cccc(Cl)c2)cc1 CHEMBL5192852 IC50 161.0 nM
CCNC(=O)Nc1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347528 IC50 164.0 nM
CCCNc1ncc(-c2cc(-c3cc(OCCC)ccc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070503 IC50 171.0 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(=O)NC)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070613 IC50 173.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)N[C@H](C)c4ccccc4)[C@@H](C)C3)c12 CHEMBL3356066 IC50 180.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]ncc34)CC2)c1 CHEMBL3613611 IC50 193.0 nM
COC(=O)Nc1ncc(-c2cc(-c3c(C)cc(OC)cc3C)nc(-c3cnccn3)n2)s1 CHEMBL2070617 IC50 202.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 205.0 nM
Cc1c[nH]c2ncnc(N3CC[C@H](C(=O)Nc4cccc(OC(=O)N(C)C)c4)[C@@H](C)C3)c12 CHEMBL3356422 IC50 210.0 nM
Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4cccc(OC(=O)N(C)C)c4)C(C)C3)c12 CHEMBL5276585 IC50 210.0 nM
Cc1c[nH]c2ncnc(C3CCN(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356068 IC50 220.0 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(=O)C(C)C)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070612 IC50 245.0 nM
NC(=O)c1cccc(-c2ccc3c(c2)sc2c(N)ncnc23)c1 CHEMBL3347689 IC50 273.0 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ccnc4[nH]ncc34)CC2)c1 CHEMBL3613612 IC50 274.0 nM
Cn1cc(-c2[nH]c3cc(NC(=O)[C@H](N)C4CCCCC4)cc4c3c2C=NNC4=O)cn1 CHEMBL3990456 pIC50 275.42 nM
Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4cccc(Br)c4)CC3)c12 CHEMBL573004 IC50 300.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 310.0 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(C)=O)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070611 IC50 311.0 nM
Cc1nc(Cn2cc(CN(Cc3ccccc3)C(=O)c3ccc(S(=O)(=O)Nc4ccccc4)cc3)nn2)cs1 CHEMBL5184915 IC50 323.0 nM
Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4cccc(OC(C)C)c4)CC3)c12 CHEMBL3356421 IC50 330.0 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(-c3ccccn3)n2)s1 CHEMBL1258633 IC50 362.0 nM
CCC(CC)Oc1cc(C)c(-c2cc(-c3cnc(NC(=O)OC)s3)nc(-c3cnccn3)n2)c(C)c1 CHEMBL2070505 IC50 382.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 390.0 nM
N#CCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2cccc(Cl)c2)cc1 CHEMBL5180888 IC50 440.0 nM
NC1(C(=O)N[C@@H](CCO)c2ccc(Cl)cc2)CCN(c2nc[nH]c3nccc2-3)CC1 CHEMBL2325741 Kd apparent 477.0 nM
COC(=O)c1cccc(NC(=O)C2(N)CCN(c3cc(NC(C)=O)ncn3)CC2)c1 CHEMBL3613618 IC50 494.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 500.0 nM
COc1cccc(NC(=O)C2CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL576712 IC50 520.0 nM
COc1cccc(NS(=O)(=O)c2ccc(C(=O)N(C)Cc3ccccc3)cc2)c1 CHEMBL3355492 IC50 540.0 nM
O=C(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)N(Cc1ccccc1)Cc1cn(Cc2cn3cccnc3n2)nn1 CHEMBL5180550 IC50 573.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F CHEMBL1230020 Kd 620.0 nM
Cc1cccc(NC(=O)C2CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL568938 IC50 650.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Cc4ccccc4)[C@@H](C)C3)c12 CHEMBL3356065 IC50 660.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 690.0 nM
Cc1ccccc1NC(=O)C1(N(C)C)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 CHEMBL3799060 IC50 700.0 nM
CCCNc1ncc(-c2cc(-c3cc(OC)ccc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070502 IC50 760.0 nM
Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4ccccc4)CC3)c12 CHEMBL570598 IC50 800.0 nM
COc1cc(-c2nn(C3CCC(N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)OCc1ccccc1 CHEMBL5290037 IC50 800.0 nM
CCCNc1ncc(-c2cc(-c3c(Cl)cc(OC4CCCC4)cc3Cl)nc(-c3cnccn3)n2)s1 CHEMBL2070499 IC50 810.0 nM
CC(=O)N1CCC(CN(C)C(=O)c2ccc(S(=O)(=O)Nc3ccccc3)cc2)CC1 CHEMBL3355500 IC50 900.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 1000.0 nM
COc1ccccc1NS(=O)(=O)c1ccc(C(=O)N(C)Cc2ccccc2)cc1 CHEMBL3355485 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM