Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(C(=O)O)ccc2n1C/C(F)=C/CN CHEMBL4457578 pIC50 3.981 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(S(C)(=O)=O)ccc2n1C/C(F)=C/CN CHEMBL4448713 pIC50 5.012 nM
CN(C)S(=O)(=O)c1ccc(Cc2cn(C/C(F)=C/CN)nn2)cc1 CHEMBL4556859 pIC50 12.59 nM
CN(C)S(=O)(=O)c1ccc(OCc2cn(C/C(F)=C/CN)nn2)c(Cl)c1 CHEMBL4531065 pIC50 19.95 nM
CN(C)S(=O)(=O)c1ccc(NCc2cn(C/C(F)=C/CN)nn2)cc1 CHEMBL4467234 pIC50 19.95 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(NS(C)(=O)=O)ccc2n1C/C(F)=C/CN CHEMBL4458907 pIC50 19.95 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2ncccc2n1C/C(F)=C/CN CHEMBL4581458 pIC50 19.95 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(C(=O)N(C)C)ccc2n1C/C(F)=C/CN CHEMBL4582216 pIC50 25.12 nM
Cc1ccc(-c2cc(S(C)(=O)=O)cc(S(=O)(=O)c3cnc(CN)s3)c2)cc1 CHEMBL4456063 IC50 28.0 nM
NCc1cc(Oc2cccc(C(=O)NCc3cc4ccccc4s3)c2)nc(C(F)(F)F)c1 CHEMBL4068580 IC50 34.0 nM
NCc1cc(Oc2cccc(C(=O)NCCS(N)(=O)=O)c2)nc(C(F)(F)F)c1 CHEMBL4084982 IC50 35.0 nM
NCc1cc(Oc2cccc(C(=O)Nc3ccccc3)c2)nc(C(F)(F)F)c1 CHEMBL4059919 IC50 42.0 nM
NCc1cc(Oc2cccc(C(=O)NCCn3cnnn3)c2)nc(C(F)(F)F)c1 CHEMBL4082808 IC50 43.0 nM
CCc1cc(CC)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4453775 IC50 45.0 nM
NCc1ccnc(Oc2cccc(C(=O)Nc3ccc(F)cc3)c2)c1 CHEMBL4086010 IC50 50.0 nM
CN(C)S(=O)(=O)c1ccc(OCc2cn(C/C(F)=C/CN)nn2)cc1 CHEMBL4569453 pIC50 50.12 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(O)ccc2n1C/C(F)=C/CN CHEMBL4550754 pIC50 50.12 nM
COc1ccc(NC(=O)c2cccc(Oc3cc(CN)ccn3)c2)cc1 CHEMBL4103928 IC50 53.0 nM
NCc1ccnc(Oc2cccc(C(=O)Nc3ccccc3)c2)c1 CHEMBL4088453 IC50 56.0 nM
NCc1ccc(S(=O)(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)s1 CHEMBL4526964 IC50 56.0 nM
CCc1cccc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4522781 IC50 56.0 nM
NCc1cc(Oc2cccc(C(=O)N3CC[C@@H](N)C3)c2)nc(C(F)(F)F)c1 CHEMBL4097435 IC50 58.0 nM
CNc1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4551841 IC50 58.0 nM
NCc1ncc(S(=O)(=O)c2cccc(-c3ccccc3)c2)s1 CHEMBL4540610 IC50 60.0 nM
NCc1ccnc(Oc2cccc(C(=O)NCc3ccccc3)c2)c1 CHEMBL4067192 IC50 62.0 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2ccc(C(=O)N(C)C)cc2n1C/C(F)=C/CN CHEMBL4574820 pIC50 63.1 nM
Cc1ccc(-c2cc(C(=O)O)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4518059 IC50 64.0 nM
CCc1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4436117 IC50 65.0 nM
N#CCCN CHEMBL1618272 IC50 66.0 nM
CS(=O)(=O)c1cc(-c2cccc(F)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4439162 IC50 66.0 nM
NCc1cc(Oc2cccc(Oc3ccccc3)c2)nc(C(F)(F)F)c1 CHEMBL4089707 IC50 67.0 nM
NCc1ncc(S(=O)(=O)c2cccc3ccccc23)s1 CHEMBL4467908 IC50 68.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4568508 IC50 69.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4457897 IC50 69.0 nM
Cc1ccc(-c2cccc(S(=O)(=O)c3cnc(CN)s3)c2)cc1 CHEMBL4573381 IC50 70.0 nM
CCc1cc(-c2ccc[n+]([O-])c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4461466 IC50 70.0 nM
COCn1cc(-c2cc(OC)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4435416 IC50 72.0 nM
NCc1ccnc(Oc2cccc(C(=O)N3C[C@@H](O)[C@H](F)C3)c2)c1 CHEMBL4063337 IC50 74.0 nM
COc1cc(-c2cnn(C3CC3)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4570730 IC50 74.0 nM
CCc1ccccc1S(=O)(=O)c1cnc(CN)s1 CHEMBL4574207 IC50 74.0 nM
Cn1cc(-c2cccc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4525828 IC50 74.0 nM
NCc1cc(Oc2cccc(C(=O)NC[C@@H](O)CO)c2)nc(C(F)(F)F)c1 CHEMBL4100783 IC50 77.0 nM
CCNC(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4590757 IC50 77.0 nM
NCc1cc(Oc2cccc(C(=O)N3C[C@@H](O)[C@H](F)C3)c2)nc(C(F)(F)F)c1 CHEMBL4079398 IC50 78.0 nM
CCc1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4444163 IC50 78.0 nM
NCc1ccnc(Oc2cccc(C(=O)NCc3cc4ccccc4s3)c2)c1 CHEMBL4093765 IC50 79.0 nM
Cn1cnc(-c2cc(S(C)(=O)=O)cc(S(=O)(=O)c3ccc(CN)s3)c2)c1 CHEMBL4472652 IC50 79.0 nM
COc1ccc2c(c1)c(-c1cccc(S(=O)(=O)N(C)C)c1)c(C)n2C/C(F)=C/CN CHEMBL4446643 pIC50 79.43 nM
CCOC(=O)c1ccc2c(c1)c(-c1cccc(S(=O)(=O)N(C)C)c1)c(C)n2C/C(F)=C/CN CHEMBL4451632 pIC50 79.43 nM
NCc1ccnc(Oc2cccc(C(=O)Nc3ccc(C(=O)O)cc3)c2)c1 CHEMBL4063420 IC50 81.0 nM
NCc1ccnc(Oc2cccc(C(=O)N3C[C@H](O)[C@@H](F)C3)c2)c1 CHEMBL4092740 IC50 82.0 nM
COc1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4468572 IC50 82.0 nM
CC(C)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4549997 IC50 82.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2csc(CN)n2)c1 CHEMBL4550042 IC50 85.0 nM
Cn1cc(-c2cc(F)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4534403 IC50 85.0 nM
Cn1cc(-c2cc(S(=O)(=O)c3cnc(CN)s3)ccc2S(C)(=O)=O)cn1 CHEMBL4552362 IC50 89.0 nM
NCc1ncc(S(=O)(=O)c2ccc3ccccc3c2)s1 CHEMBL4551082 IC50 90.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4444826 IC50 90.0 nM
CCn1cc(-c2cc(OC)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4483542 IC50 94.0 nM
CONC(=O)c1cccc(Oc2cc(CN)cc(C(F)(F)F)n2)c1 CHEMBL4105137 IC50 96.0 nM
COc1ccc(S(=O)(=O)c2cnc(CN)s2)cc1-c1cnn(C)c1 CHEMBL4516505 IC50 96.0 nM
CN(C)S(=O)(=O)c1cccc(-c2ccn(C/C(F)=C/CN)c2)c1 CHEMBL4463296 pIC50 100.0 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2ccccc2n1C/C(F)=C/CN CHEMBL4472333 pIC50 100.0 nM
NCc1cc(N2CCN(CC(=O)c3ccccc3)CC2)ncn1 CHEMBL4519539 IC50 100.0 nM
NCc1cc(N2CCN(C(=O)Nc3ccccc3)CC2)ncn1 CHEMBL4592316 IC50 100.0 nM
NCc1cc(N2CCC(C(=O)Nc3ccccc3)CC2)ncn1 CHEMBL4445580 IC50 100.0 nM
NCc1cc(N2CC[C@@H](C(=O)Nc3ccccc3)C2)ncn1 CHEMBL4462086 IC50 100.0 nM
NCc1cc(NCc2cccc(C(=O)N3CCN(c4ccccc4)CC3)c2)ncn1 CHEMBL4470687 IC50 100.0 nM
NCc1cc(-n2ccc3c(CO)cccc32)ncn1 CHEMBL4458278 IC50 100.0 nM
CC(Oc1cc(CN)ncn1)c1cccc(C(=O)Nc2ccccc2)c1 CHEMBL4534716 IC50 100.0 nM
NCc1cc(Oc2cccc3c2ccn3C2COC2)ncn1 CHEMBL4536040 IC50 100.0 nM
CN(Cc1cccc(C(=O)Nc2ccccc2)c1)c1cc(CN)ncn1 CHEMBL4549270 IC50 100.0 nM
NCc1cc(NCc2cccc(C(=O)Nc3ccc(C(=O)O)cc3)c2)ncn1 CHEMBL4436842 IC50 100.0 nM
NCc1cc(Oc2cccc3c2ccn3CC(=O)N2CCCCC2)ncn1 CHEMBL4454221 IC50 100.0 nM
NCc1cc(Oc2cccc3c2CCC(=O)N3CC(=O)O)ncn1 CHEMBL4560168 IC50 100.0 nM
NCc1cc(Oc2cccc(C(=O)NCCCC(=O)O)c2)ncn1 CHEMBL4584769 IC50 100.0 nM
NCc1cc(Oc2cccc(C(=O)NCCC(=O)O)c2)ncn1 CHEMBL4449826 IC50 100.0 nM
NCc1ncc(S(=O)(=O)c2ccc3c(c2)CCCC3)s1 CHEMBL4465683 IC50 100.0 nM
Cc1ccc(-c2cc(S(C)(=O)=O)cc(S(=O)(=O)c3cnc(CN)s3)c2)cc1 CHEMBL4515085 IC50 103.0 nM
NCc1cc(Oc2cccc(C(=O)N3CC[C@@H](O)C3)c2)nc(C(F)(F)F)c1 CHEMBL4071963 IC50 110.0 nM
COc1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4474550 IC50 110.0 nM
NCc1ncc(S(=O)(=O)c2cnc(-c3ccccc3)nc2)s1 CHEMBL4577839 IC50 110.0 nM
NCc1ccnc(Oc2cccc(C(=O)N3CCc4ccccc4C3)c2)c1 CHEMBL4066192 IC50 120.0 nM
NCc1ncc(S(=O)(=O)c2ccc3ccccc3c2)s1 CHEMBL4457629 IC50 120.0 nM
NCc1ccc(S(=O)(=O)c2cccc(S(=O)(=O)N3CCCC3c3ccccc3)c2)s1 CHEMBL4529150 IC50 120.0 nM
CN(C)S(=O)(=O)c1ccc(-c2cn(C/C(F)=C/CN)nn2)cc1 CHEMBL4581561 pIC50 125.89 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(Cl)ccc2n1C/C(F)=C/CN CHEMBL4438235 pIC50 125.89 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(-c3nnn[nH]3)ccc2n1C/C(F)=C/CN CHEMBL4446904 pIC50 125.89 nM
NCc1ccnc(Cl)c1 CHEMBL4068784 IC50 126.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2ccc(CN)s2)c1 CHEMBL4441173 IC50 126.0 nM
NCc1cc(O[C@H]2CCCN(C(=O)Nc3ccccc3)C2)nc(C(F)(F)F)c1 CHEMBL4087273 IC50 130.0 nM
CCc1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4522646 IC50 130.0 nM
CS(=O)(=O)c1cc(-c2ccc(F)cc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4535310 IC50 140.0 nM
COc1cc(-c2cn(C)cn2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4547000 IC50 140.0 nM
CCc1cc(-c2ccsc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4441735 IC50 140.0 nM
Cn1cc(-c2cc(F)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4460845 IC50 143.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)cc(S(=O)(=O)c3csc(CN)n3)c2)cn1 CHEMBL4574361 IC50 146.0 nM
CCN(CC)C(=S)SSC(=S)N(CC)CC CHEMBL964 IC50 150.0 nM
CCNC(=O)c1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4517798 IC50 150.0 nM
CCc1cc(-c2c(C)noc2C)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4549214 IC50 150.0 nM
COCCNC(=O)c1cccc(Oc2cc(CN)ccn2)c1 CHEMBL4078119 IC50 160.0 nM
CN(C)C(=S)SSC(=S)N(C)C CHEMBL120563 IC50 170.0 nM
CS(=O)(=O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4573809 IC50 170.0 nM
CC(C)NC(=O)c1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4593658 IC50 170.0 nM
CC(C)(C)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4456842 IC50 170.0 nM
CS(=O)(=O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4468424 IC50 174.0 nM
CCc1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2csc(CN)n2)c1 CHEMBL4463882 IC50 176.0 nM
N=C(N)c1ccc(CNC(=O)c2cccc(Oc3cc(CN)ccn3)c2)cc1 CHEMBL4085053 IC50 180.0 nM
CN(C)C(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4451663 IC50 180.0 nM
CS(=O)(=O)c1cc(-c2cn[nH]c2)cc(S(=O)(=O)c2ccc(CN)s2)c1 CHEMBL4471888 IC50 180.0 nM
CS(=O)(=O)c1cccc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4467411 IC50 184.0 nM
Cc1ccc(-c2cc(S(C)(=O)=O)cc(S(=O)(=O)c3ccc(CN)s3)c2)cc1 CHEMBL4564517 IC50 190.0 nM
CS(=O)(=O)c1cc(-c2ccc(F)cc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4545533 IC50 192.0 nM
CS(=O)(=O)c1ccc(OCc2cn(C/C(F)=C/CN)nn2)cc1 CHEMBL4450939 pIC50 199.53 nM
Cn1cc(-c2cc(C(=O)N3CC[C@@H](O)C3)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4466536 IC50 200.0 nM
NCc1ccc(S(=O)(=O)c2ccc3ccccc3c2)s1 CHEMBL4443558 IC50 200.0 nM
NCCS(=O)(=O)c1cnc(CN)s1 CHEMBL4461394 IC50 200.0 nM
NCc1ncc(S(=O)(=O)c2cc3ccccc3c3ccccc23)s1 CHEMBL4468215 IC50 200.0 nM
NCc1ccnc(-n2ccnc2)c1 CHEMBL4099444 IC50 203.0 nM
CS(=O)(=O)c1ccc(S(=O)(=O)c2cnc(CN)s2)c(-c2ccccc2)c1 CHEMBL4454209 IC50 220.0 nM
CS(=O)(=O)c1ccc(S(=O)(=O)c2ccc(CN)s2)cc1-c1ccc(F)cc1 CHEMBL4578527 IC50 220.0 nM
NCc1ncc(S(=O)(=O)c2ccc3cccnc3c2)s1 CHEMBL4460490 IC50 230.0 nM
NCc1nc(S(=O)(=O)c2ccc3ccccc3c2)cs1 CHEMBL4585138 IC50 230.0 nM
CS(=O)(=O)c1cc(Sc2cnc(CN)s2)cc(-c2ccccc2)c1 CHEMBL4441069 IC50 233.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc([S+]([O-])c2cnc(CN)s2)c1 CHEMBL4441130 IC50 236.0 nM
NCc1ncc(S(=O)(=O)c2cc(C(=O)O)cc(-c3ccccc3)c2)s1 CHEMBL4548488 IC50 240.0 nM
Cn1cc(-c2cc(C(=O)O)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4437983 IC50 240.0 nM
CN(C)S(=O)(=O)c1ccc(-c2ccn(C/C(F)=C/CN)c2)cc1 CHEMBL4531248 pIC50 251.19 nM
COc1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4462499 IC50 255.0 nM
Cn1cc(-c2cc(C(F)(F)F)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4442153 IC50 259.0 nM
Cc1ccc(-c2cc(S(=O)(=O)c3cnc(CN)s3)ccc2S(C)(=O)=O)cc1 CHEMBL4576894 IC50 260.0 nM
NCc1ncc(S(=O)(=O)c2cc(C(=O)N3CCC(O)C3)cc(-c3ccccc3)c2)s1 CHEMBL4548731 IC50 260.0 nM
Cc1ccc(-c2cc(S(=O)(=O)c3ccc(CN)s3)ccc2S(C)(=O)=O)cc1 CHEMBL4434955 IC50 260.0 nM
NCc1ncc(S(=O)(=O)c2ccccc2)s1 CHEMBL4471295 IC50 260.0 nM
NCc1ccnc(Oc2ccc(C(=O)Nc3ccccc3)cc2)c1 CHEMBL4096173 IC50 270.0 nM
CS(=O)(=O)c1cccc(S(=O)(=O)c2ccc(CN)s2)c1 CHEMBL4458145 IC50 270.0 nM
Cn1cc(-c2cc(Cl)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4565733 IC50 280.0 nM
NCc1ncc(S(=O)(=O)c2cc(C(=O)O)cc(N3CCCC3)c2)s1 CHEMBL4533353 IC50 280.0 nM
NCc1cc(Oc2cccc(C(=O)N3CCC[C@@H]3C(=O)O)c2)nc(C(F)(F)F)c1 CHEMBL4440464 IC50 300.0 nM
NCc1cc(O[C@@H]2CCCN(C(=O)Nc3ccccc3)C2)nc(C(F)(F)F)c1 CHEMBL4541536 IC50 300.0 nM
Cc1nnc(C(=O)N2CCC[C@H](Oc3cc(CN)cc(C(F)(F)F)n3)C2)o1 CHEMBL4514273 IC50 300.0 nM
NCc1cc(OC[C@H]2CCCN(C(=O)Nc3ccccc3)C2)nc(C(F)(F)F)c1 CHEMBL4552991 IC50 300.0 nM
NCc1cc(OC2CCN(C(=O)Nc3ccccc3)CC2)nc(C(F)(F)F)c1 CHEMBL4467589 IC50 300.0 nM
NCc1cc(Oc2cccc3c2ccn3CC(=O)N2CCCCC2)nc(C(F)(F)F)c1 CHEMBL4441733 IC50 300.0 nM
NCc1cc(Oc2cccc(C(=O)NO)c2)nc(C(F)(F)F)c1 CHEMBL4454115 IC50 300.0 nM
C#C[C@H](CC(=O)O)NC(=O)c1cccc(Oc2cc(CN)cc(C(F)(F)F)n2)c1 CHEMBL4465211 IC50 300.0 nM
C#C[C@@H](CC(=O)O)NC(=O)c1cccc(Oc2cc(CN)cc(C(F)(F)F)n2)c1 CHEMBL4466467 IC50 300.0 nM
NCc1cc(Oc2cccc(C(=O)O)c2)nc(C(F)(F)F)c1 CHEMBL4441900 IC50 300.0 nM
NCc1cc(Oc2cc(C(=O)N3C[C@H](O)[C@@H](F)C3)ccc2O)nc(C(F)(F)F)c1 CHEMBL4447816 IC50 300.0 nM
COc1cc(Oc2cc(CN)cc(C(F)(F)F)n2)cc(C(=O)N2C[C@H](O)[C@@H](F)C2)c1 CHEMBL4441145 IC50 300.0 nM
NCc1cc(Oc2cccc3c2CCC(=O)N3CCO)nc(C(F)(F)F)c1 CHEMBL4563725 IC50 300.0 nM
CCOC(=O)CN1C(=O)CCc2c(Oc3cc(CN)cc(C(F)(F)F)n3)cccc21 CHEMBL4469877 IC50 300.0 nM
NCc1cc(Oc2cccc3c2ccn3CC(=O)N2CCNCC2)nc(C(F)(F)F)c1 CHEMBL4437718 IC50 300.0 nM
CC(=O)N1CCC2(CC(Oc3cc(CN)cc(C(F)(F)F)n3)C2)C1 CHEMBL4565229 IC50 300.0 nM
NCc1cc(NCc2cccc(C(=O)N3CC[C@H](O)C3)c2)nc(C(F)(F)F)c1 CHEMBL4466816 IC50 300.0 nM
Cc1cc(=O)n(Cc2cc(CN)cc(C(F)(F)F)n2)c(=O)n1Cc1ccncn1 CHEMBL4515613 IC50 300.0 nM
NCc1cc(=O)c2cc(-c3cn(CCO)nn3)ccc2o1 CHEMBL4465110 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)N3CCCCC3)ccc2o1 CHEMBL4443839 IC50 300.0 nM
NCc1cc(=O)c2cc(N3CC[C@H](O)C3)ccc2o1 CHEMBL4550673 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)NCCn3cncn3)ccc2o1 CHEMBL4519228 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)NCCS(N)(=O)=O)ccc2o1 CHEMBL4436599 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)N3CC[C@@H](N)C3)ccc2o1 CHEMBL4463294 IC50 300.0 nM
COC(=O)[C@@H]1CCN(C(=O)c2ccc3oc(CN)cc(=O)c3c2)C1 CHEMBL4467197 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)N3CC(O)C(F)C3)ccc2o1 CHEMBL4519821 IC50 300.0 nM
CS(=O)(=O)CCNC(=O)c1ccc2oc(CN)cc(=O)c2c1 CHEMBL4520871 IC50 300.0 nM
C#Cc1ccc2c(=O)cc(CN)oc2c1 CHEMBL4472778 IC50 300.0 nM
CN(C)C(=O)COc1ccc2c(=O)cc(CN)oc2c1 CHEMBL4439263 IC50 300.0 nM
NCc1cc(=O)c2cc(OCC(=O)O)ccc2o1 CHEMBL4449126 IC50 300.0 nM
CN(C)C(=O)COc1ccc2oc(CN)cc(=O)c2c1 CHEMBL4451458 IC50 300.0 nM
NCc1cc(=O)c2ccc(O)cc2o1 CHEMBL4543922 IC50 300.0 nM
NCc1cc(=O)c2cccc(Br)c2o1 CHEMBL4438377 IC50 300.0 nM
NCc1cc(=O)c2cccc(O)c2o1 CHEMBL4553481 IC50 300.0 nM
C#CCOc1cccc2c(=O)cc(CN)oc12 CHEMBL4539353 IC50 300.0 nM
NCc1cc(=O)c2cccc(OCc3ccccc3)c2o1 CHEMBL4463403 IC50 300.0 nM
NCc1cc(=O)c2cccc(OCCc3ccccc3)c2o1 CHEMBL4449222 IC50 300.0 nM
NCc1cc(=O)c2cccc(OCC(=O)Nc3ccccc3)c2o1 CHEMBL4455789 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)NCCO)ccc2o1 CHEMBL4465977 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)N3C[C@H](O)[C@@H](F)C3)ccc2o1 CHEMBL4483328 IC50 300.0 nM
NCc1cc(=O)c2cc(C(=O)N3C[C@@H](O)[C@H](F)C3)ccc2o1 CHEMBL4462300 IC50 300.0 nM
NCc1ccnnc1 CHEMBL4542036 IC50 300.0 nM
NCc1cc(Oc2cccc(C(=O)Nc3ccccc3)c2)n2nccc2n1 CHEMBL4514662 IC50 300.0 nM
NCc1ccnc(Oc2cccc(C(=O)Nc3ccccc3)c2)n1 CHEMBL4528326 IC50 300.0 nM
NCc1cc2ccccc2c(=O)[nH]1 CHEMBL4535883 IC50 300.0 nM
NCCc1nc(-c2ccncc2)cs1 CHEMBL4571904 IC50 300.0 nM
NCCc1nc(-c2ccccc2)cs1 CHEMBL1624419 IC50 300.0 nM
NCc1cc(O)n2nccc2n1 CHEMBL4566280 IC50 300.0 nM
CC(CN)c1nc2ccccc2s1 CHEMBL4548981 IC50 300.0 nM
NCCc1nc2ccccc2o1 CHEMBL4546058 IC50 300.0 nM
NCc1nc2cc(Cl)ccc2s1 CHEMBL4540729 IC50 300.0 nM
NCc1sc2ccccc2c1Cl CHEMBL4556698 IC50 300.0 nM
NCc1cc2ccccc2s1 CHEMBL1770735 IC50 300.0 nM
NCc1cc2ccccc2o1 CHEMBL4578553 IC50 300.0 nM
NCc1cc2cc(-c3ccc(OCc4ccccc4)nc3)ccc2[nH]1 CHEMBL4531909 IC50 300.0 nM
COc1ncccc1-c1ccc2[nH]c(CN)cc2c1 CHEMBL4524949 IC50 300.0 nM
COc1ccc(-c2ccc3[nH]c(CN)cc3c2)cn1 CHEMBL4567577 IC50 300.0 nM
NCc1cc2cc(-c3cncc(O)c3)ccc2[nH]1 CHEMBL4533736 IC50 300.0 nM
Cn1cc(-c2ccc3[nH]c(CN)cc3c2)cn1 CHEMBL4527351 IC50 300.0 nM
COc1ccc2[nH]c(CN)cc2c1 CHEMBL4527127 IC50 300.0 nM
NCc1cc2cc(Cl)ccc2[nH]1 CHEMBL4575722 IC50 300.0 nM
Cc1ccc2[nH]c(CN)cc2c1 CHEMBL4576455 IC50 300.0 nM
NCc1cc2ccccc2[nH]1 CHEMBL2229816 IC50 300.0 nM
NCc1ccnc(Oc2ccccc2)c1 CHEMBL3467241 IC50 309.0 nM
NCc1ccnc(Oc2ccccc2)c1 CHEMBL4063906 IC50 310.0 nM
NCc1ncc(S(=O)(=O)c2ccccc2)s1 CHEMBL4586111 IC50 310.0 nM
Cn1cc(-c2cc(C(F)(F)F)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1 CHEMBL4584859 IC50 310.0 nM
CN(C)C(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2csc(CN)n2)c1 CHEMBL4483628 IC50 310.0 nM
NC/C=C(\F)Cn1cc(COc2ccccc2)nn1 CHEMBL4441299 pIC50 316.23 nM
C[C@H](NS(=O)(=O)c1ccc(OC/C(F)=C/CN)cc1)c1ccccc1 CHEMBL4439437 pIC50 316.23 nM
CCc1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2csc(CN)n2)c1 CHEMBL4476340 IC50 320.0 nM
NCc1ccnc(-c2cccnc2)c1 CHEMBL4072524 IC50 321.0 nM
NCc1ncc(S(=O)(=O)c2cccc(-c3ccccc3)c2)s1 CHEMBL4447452 IC50 342.0 nM
CC(C)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4470882 IC50 343.0 nM
CCc1cc(-c2ccccc2)cc(S(=O)(=O)c2ccc(CN)s2)c1 CHEMBL4443549 IC50 370.0 nM
CCc1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4564074 IC50 380.0 nM
Cn1cc(-c2cc(S(=O)(=O)c3ccc(CN)s3)ccc2S(C)(=O)=O)cn1 CHEMBL4474125 IC50 380.0 nM
NCc1ccnc(F)c1 CHEMBL4103840 IC50 385.0 nM
CS(=O)(=O)c1cccc(-c2cnc(CN)s2)c1 CHEMBL4540485 IC50 394.0 nM
CNc1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4450748 IC50 397.0 nM
[2H]C([2H])(N)c1ccc(S(=O)(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)s1 CHEMBL4456390 IC50 400.0 nM
COc1cc(-c2cn[nH]c2)cc(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4471297 IC50 410.0 nM
COc1cc(-c2ccccc2)cc(S(=O)(=O)c2ccc(CN)s2)c1 CHEMBL4451338 IC50 420.0 nM
Cc1ccc(-c2cc(S(=O)(=O)c3cnc(CN)s3)ccc2S(C)(=O)=O)cc1 CHEMBL4457668 IC50 423.0 nM
NCc1ccncc1F CHEMBL4079586 IC50 431.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cc(F)c(CN)s2)c1 CHEMBL4450132 IC50 460.0 nM
CS(=O)(=O)c1cc(S(=O)(=O)c2ccc(CN)s2)ccc1-c1ccccc1 CHEMBL4584147 IC50 480.0 nM
COCCNC(=O)c1ccc(Oc2cc(CN)ccn2)cc1 CHEMBL4085480 IC50 500.0 nM
CC(C)(C)c1ccc(S(=O)(=O)c2cnc(CN)s2)cc1 CHEMBL4555200 IC50 500.0 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2ccc(C(=O)O)cc2n1C/C(F)=C/CN CHEMBL4457469 pIC50 501.19 nM
CCCS(=O)(=O)c1cnc(CN)s1 CHEMBL4466690 IC50 554.0 nM
NCc1ncc(S(=O)(=O)c2cc(C(=O)NCCO)cc(-c3ccccc3)c2)s1 CHEMBL4468175 IC50 560.0 nM
NCc1cc(O[C@@H]2CCCN(C(=O)Nc3ccccc3)C2)nc(C(F)(F)F)c1 CHEMBL4081837 IC50 570.0 nM
NCc1ncc(S(=O)(=O)C2CCCCC2)s1 CHEMBL4456211 IC50 606.0 nM
COc1cc(S(=O)(=O)c2cnc(CN)s2)cc(OC)c1OC CHEMBL4441053 IC50 640.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc(-c2cnc(CN)s2)c1 CHEMBL4551909 IC50 652.0 nM
N#Cc1ccc(CN)cc1 CHEMBL4068773 IC50 670.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)cc(S(=O)(=O)c2cc(F)c(CN)s2)c1 CHEMBL4552697 IC50 671.0 nM
NCc1ncc(S(=O)(=O)C2CCCCC2)s1 CHEMBL4587595 IC50 680.0 nM
Cc1ccc(-c2cc(S(=O)(=O)c3ccc(CN)s3)ccc2S(C)(=O)=O)cc1 CHEMBL4528500 IC50 686.0 nM
NCc1ccc([N+](=O)[O-])cc1 CHEMBL1235374 IC50 719.0 nM
CC(C)(C)c1ccc(OCc2cn(C/C(F)=C/CN)nn2)cc1 CHEMBL4459524 pIC50 794.33 nM
CS(=O)(=O)c1cccc(OCc2cn(C/C(F)=C/CN)nn2)c1 CHEMBL4443268 pIC50 794.33 nM
CN(C)C(=O)c1ccc(OCc2cn(C/C(F)=C/CN)nn2)cc1 CHEMBL4554097 pIC50 794.33 nM
Cc1c(-c2ccc(S(=O)(=O)N(C)C)cc2)c2ccccc2n1C/C(F)=C/CN CHEMBL4527340 pIC50 794.33 nM
Cc1c(-c2cccc(S(=O)(=O)N(C)C)c2)c2cc(C(=O)O)ccc2n1C/C=C/CN CHEMBL4586209 pIC50 794.33 nM
CS(=O)(=O)c1ccc(-c2ccccc2)c(S(=O)(=O)c2cnc(CN)s2)c1 CHEMBL4466774 IC50 800.0 nM
NCc1nc(S(=O)(=O)c2ccc3ccccc3c2)cs1 CHEMBL4456682 IC50 828.0 nM
NCc1ccnc(OC2CCCCC2)c1 CHEMBL4075255 IC50 850.0 nM
NCc1ccc(-c2nccs2)cc1 CHEMBL4075843 IC50 902.0 nM
NCc1ccnc(C(F)(F)F)c1 CHEMBL4096085 IC50 999.0 nM
NCc1ccnc(C(F)(F)F)c1 CHEMBL4066637 IC50 1000.0 nM
CCN1/C(=C2\C(=O)N(c3ccccc3)N=C2Nc2ccccc2)C=Cc2ccccc21 CHEMBL4240937 IC50 1000.0 nM
NCc1ncc([S+]([O-])c2ccccc2)s1 CHEMBL4460929 IC50 1000.0 nM
NCc1ccc(S(=O)(=O)c2cnn(-c3ccccc3)c2)s1 CHEMBL4441170 IC50 1000.0 nM