C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F CHEMBL4546504 IC50 0.001 nM
Cc1cccc(-c2cc(Nc3ccn(C)n3)nc3[nH]cc(C#N)c23)c1 CHEMBL3969077 Ki 0.06 nM
CC1NN=CC1Nc1ncc2cc(Cl)c(N3CCC(C)(O)C(C)C3)cc2n1 CHEMBL5189225 pIC50 0.06457 nM
CC(C)(O)CN1CCN(c2cc3nc(Nc4cnn(C5CC5)c4Cl)ncc3cc2Cl)CC1 CHEMBL5195441 pIC50 0.07586 nM
N#CC1CCN(c2cc3cc(NC(=O)C4CC4c4cncnc4)ncc3cc2Cl)CC1 CHEMBL5198416 pIC50 0.08128 nM
CCC1C(C(=O)Nc2cc3cc(N4CCN(C5(C)COCC5F)CC4)c(C)cc3cn2)C1c1cnn(C)c1 CHEMBL5177202 pIC50 0.08128 nM
CC1(N2CCN(c3cc4cc(NC(=O)C5CC5c5cccs5)ncc4cc3Cl)CC2)COCC1O CHEMBL5191262 pIC50 0.08128 nM
Cn1ncc(C2CC2C(=O)Nc2cc3cc(N4CCN(C5(C)COCC5O)CC4)c(Cl)cc3cn2)n1 CHEMBL5171075 pIC50 0.08128 nM
CC1(N2CCC(c3cc4cc(NC(=O)c5cnn(C6CC6)c5Cl)ncc4cc3Cl)CC2)COCC1O CHEMBL5283649 pIC50 0.08128 nM
CC1(N2CCC(c3cc4cc(NC(=O)Cc5ccncc5)ncc4cc3Cl)CC2)COCC1O CHEMBL5273196 pIC50 0.08128 nM
CC1(N2CCC(c3cc4cc(NC(=O)C5CC5c5ccccn5)ncc4cc3F)CC2)COCC1O CHEMBL5266868 pIC50 0.08128 nM
Cc1cc2cnc(NC(=O)C3CC34CCOCC4)cc2cc1C1CCN(C2(C)COCC2O)CC1 CHEMBL5276281 pIC50 0.08128 nM
Cn1ncc(C2CC2C(=O)Nc2cc3cc(C4CCN(C5(C)COCC5O)CC4)c(Cl)cc3cn2)n1 CHEMBL5283143 pIC50 0.08128 nM
C[C@@]1(N2CC[C@@H](c3cc4cc(NC(=O)C5CC56CC6)ncc4cc3Cl)[C@H](F)C2)COC[C@@H]1O CHEMBL5289583 pIC50 0.08128 nM
CCOC1CC1C(=O)Nc1cc2cc(N3CCN(C4(C)COCC4O)CC3)c(Cl)cc2cn1 CHEMBL5200393 pIC50 0.08318 nM
C[C@@H]1CCCN1c1c(C#N)c2c(N)nc(Nc3cnn(C)c3)nc2n1C CHEMBL5075978 Ki 0.1 nM
CC1(C2CCOC2)CC1C(=O)Nc1cc2cc(N3CCN(C4(C)COCC4O)CC3)c(Cl)cc2cn1 CHEMBL5203973 pIC50 0.1 nM
COC(C)(C)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(C3CCN([C@]4(C)COC[C@@H]4O)CC3)c(Cl)cc2cn1 CHEMBL5422978 IC50 0.11 nM
CC1(O)CCN(c2cc3nc(Nc4cnn(C5CC5)c4Cl)ncc3cc2Cl)C1 CHEMBL5206036 pIC50 0.169 nM
Clc1cc2cnc(Nc3cnn(C45CC(C4)C5)c3Cl)nc2cc1N1CCC2(CCCO2)CC1 CHEMBL5199715 pIC50 0.1742 nM
CC(C)(C)Cn1cc(Nc2ncc3cc(Cl)c(N4CCC(C5(C)COC5)CC4)cc3n2)cn1 CHEMBL5201483 pIC50 0.1875 nM
C[C@@H]1CCCN1c1c(C#N)c2c(N)nc(Nc3cn[nH]c3)nc2n1C CHEMBL5091909 Ki 0.2 nM
C[C@@]1(N2CCC(c3cc4cc(NC(=O)[C@H]5CC56CCOCC6)ncc4cc3Cl)CC2)COC[C@@H]1O CHEMBL5396547 IC50 0.2 nM
C[C@@]1(N2CCC(c3cc4cc(NC(=O)[C@H]5C[C@@H]5c5ccccn5)ncc4cc3Cl)CC2)COC[C@@H]1O CHEMBL5400861 fIC50 0.2 nM
Cn1cc([C@H]2C[C@@H]2C(=O)Nc2cc3cc(C4CCN([C@]5(C)COC[C@@H]5O)CC4)c(Cl)cc3cn2)cn1 CHEMBL5419587 fIC50 0.28 nM
Cn1cc(/C=C/c2n[nH]c3ccnc(OC4CCCCC4)c23)cn1 CHEMBL2152707 Ki 0.3 nM
CNc1nc(Nc2cc(C)c(S(C)(=O)=O)cc2OC)ncc1C(F)(F)F CHEMBL3942517 Ki 0.3 nM
CCNc1nc(Nc2cn(C(C)(C)c3ccnn3C)nc2C)ncc1C(F)(F)F CHEMBL3923102 Ki 0.3 nM
CCNc1nc(Nc2cnn3c2COC(C)(C)C3)ncc1C(F)(F)F CHEMBL3890082 Ki 0.3 nM
CC(C)(O)[C@@H]1CCN(c2cnc(C(F)(F)F)c(NC(=O)c3cccc(-c4cnn(CC5(C(F)(F)F)CC5)c4)n3)c2)C1 CHEMBL5172416 IC50 0.3 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ccn2)C[C@H](C)O1 CHEMBL5267350 IC50 0.3 nM
CC(C)(O)C12CC(C1)N(c1cc(-n3ncc4ccc([C@]5(C#N)CC56CC6)cc43)ncn1)C2 CHEMBL5286106 IC50 0.3 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(N5CCOCC5)c4)c3c2)C(C)(C)n2nnnc2N1C CHEMBL5270706 IC50 0.3 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 0.3162 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.39 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 0.3981 nM
C[C@@H]1CCCN1c1c(C#N)c2c(N)ncnc2n1C CHEMBL5086513 Ki 0.4 nM
CC(C)(O)[C@@H]1CCN(c2cnc(C(F)(F)F)c(NC(=O)c3cccc(-c4cnn(CC5CC5)c4)n3)c2)C1 CHEMBL5181104 IC50 0.4 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1 CHEMBL4098877 IC50 0.4 nM
CC(C)(O)C12CC(C1)N(c1cc(-n3ncc4ccc([C@]5(C#N)CC56CC6)cc43)ncn1)C2 CHEMBL5284341 IC50 0.4 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)Cn2nnnc2N1C CHEMBL5274608 IC50 0.4 nM
N#Cc1ccc2c(c1)CC[C@@H]2Oc1ccc2[nH]nc(-c3cnco3)c2c1 CHEMBL5436466 IC50 0.4 nM
C[C@@]1(N2CCN(c3cc4cc(NC(=O)[C@H]5CC56CCOCC6)ncc4cc3Cl)CC2)COC[C@@H]1O CHEMBL5408287 IC50 0.4 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccncc4)c3c2)Cn2nnnc2N1C CHEMBL5279036 IC50 0.44 nM
Cc1c(Nc2ncc3cc(Cl)c(N4C(=O)OC[C@H]4C)cc3n2)cnn1C1CCOCC1 CHEMBL5204653 pIC50 0.4508 nM
CCNc1nc(Nc2cn(C(C)(C)c3ncn(C)n3)nc2Cl)ncc1C(F)(F)F CHEMBL3933443 Ki 0.5 nM
Cc1cccc(-c2cc(N)nc3[nH]cc(C#N)c23)c1 CHEMBL3961632 Ki 0.5 nM
CCc1cc(-c2n[nH]c3ccnc(NC4CCOCC4)c23)nn1C CHEMBL4539170 Ki 0.5 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)Cn2nnnc2N1C CHEMBL5288427 IC50 0.53 nM
O[C@H]1COC[C@H]1N1CC[C@@H](c2cc3nc(Nc4cnn([C@@H]5CC5(F)F)c4Cl)ncc3cc2Cl)[C@H](F)C1 CHEMBL5076397 fIC50 0.57 nM
CNc1nc(Nc2ccc(C(=O)NC3CCN(C)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3643968 Ki 0.6 nM
CCNc1nc(Nc2cc(F)c(C(=O)N3CCC[C@H]3COC)cc2OC)ncc1C(F)(F)F CHEMBL3643987 Ki 0.6 nM
CCNc1nc(Nc2cn(C(C)(C)c3ncn(C(C)C)n3)nc2C)ncc1C(F)(F)F CHEMBL3967223 Ki 0.6 nM
CNc1nc(Nc2cn(C3CCOC[C@H]3F)nc2C)ncc1C(F)(F)F CHEMBL4114199 Ki 0.6 nM
CNc1nc(Nc2cnn(C3CCOC[C@@H]3F)c2C)ncc1C(F)(F)F CHEMBL3904575 Ki 0.6 nM
CNc1nc(Nc2cnn3c2CCC3)ncc1C(F)(F)F CHEMBL3962633 Ki 0.6 nM
CNc1nc(Nc2cn(C(C)(C)C#N)nc2C)ncc1C(F)(F)F CHEMBL3122113 Ki 0.6 nM
Cn1ccc([C@H]2C[C@@H]2C(=O)Nc2cc3cc(C4CCN([C@]5(C)COC[C@@H]5O)CC4)c(Cl)cc3cn2)n1 CHEMBL5428129 IC50 0.6 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 0.631 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 0.631 nM
Cc1c(Nc2ncc3cc(Cl)c(C4CCN(C5COC5)CC4)cc3n2)cnn1C1CC1 CHEMBL5089102 IC50 0.65 nM
CCNc1nc(Nc2cc(C(C)(C)C#N)nn2C)ncc1C(F)(F)F CHEMBL3122119 Ki 0.7 nM
CC(C)Oc1ccc2[nH]nc(-c3ccnc(N4CCOCC4)c3)c2c1 CHEMBL4100904 IC50 0.7 nM
Cc1c(Nc2ncc3ccc(C4(C#N)CC4)cc3n2)cnn1C1CCOCC1 CHEMBL5094138 IC50 0.7 nM
CC(C)(O)[C@@H]1CCN(c2cnc(C(F)(F)F)c(NC(=O)c3cccc(-c4cnn(CC(F)(F)F)c4)n3)c2)C1 CHEMBL5197547 IC50 0.7 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccc(S(N)(=O)=O)cc4)c3c2)Cn2nnnc2N1C CHEMBL5284027 IC50 0.7 nM
CC1(N2CCC(c3cc4c(cnn4-c4cnn(C56CC(C5)C6)c4)cc3Cl)CC2)COC1 CHEMBL4764691 IC50 0.71 nM
CC(C)N1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CC1 CHEMBL3902701 IC50 0.73 nM
COc1ccncc1-c1ccc2[nH]nc(-c3cc(N4C[C@@H](C)O[C@@H](C)C4)ncn3)c2c1 CHEMBL3921329 IC50 0.75 nM
CCN1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CC1 CHEMBL3890426 IC50 0.76 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 0.7943 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(N(C)C)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3643963 Ki 0.8 nM
CC(C)Oc1ccc2[nH]nc(-c3ccnc(N4CCN(C)CC4)c3)c2c1 CHEMBL4093185 IC50 0.8 nM
CCn1cc(-n2ncc3cc(Cl)c(C4CCN(C5(C)COC5)CC4)cc32)cn1 CHEMBL4791349 IC50 0.8 nM
C[C@@H]1CCCN1c1c(C#N)c2c(N)nccc2n1C CHEMBL5090953 Ki 0.8 nM
CC(C)(O)Cn1ncc(Nc2ncc3cc(Cl)c(C4CCN(C5COC5)CC4)cc3n2)c1Cl CHEMBL5073571 IC50 0.8 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(C)c3c2)C(C)(C)n2nnnc2N1C CHEMBL5280577 IC50 0.8 nM
Cn1cc(C(=O)Nc2cc3cc(C4CCN([C@]5(C)COC[C@@H]5O)CC4)c(Cl)cc3cn2)cn1 CHEMBL5411697 IC50 0.8 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(C)c3c2)[C@@H](C)n2nnnc2N1C CHEMBL5279816 IC50 0.82 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 0.86 nM
CNc1nc(Nc2cnn3c2COC(C)(C)C3)ncc1C(F)(F)F CHEMBL3122105 Ki 0.9 nM
CC(C)(O)[C@@H]1CCN(c2cc(-n3ncc4ccc(C5(C#N)CC6(CC6)C5)cc43)ncn2)C1 CHEMBL4553532 IC50 0.9 nM
Clc1cc2cnn(-c3cnn(C4CCC4)c3)c2cc1C1CCN(C2COC2)CC1 CHEMBL4763199 IC50 0.9 nM
N#Cc1ccc2c(c1)CCC[C@@H]2Nc1ccc2[nH]nc(-c3cnco3)c2c1 CHEMBL5413127 IC50 0.9 nM
Cc1cn(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CN(C)CC2(F)F)nn1 CHEMBL4460909 IC50 0.94 nM
CCNc1nc(Nc2cn(S(=O)(=O)CCOC)nc2C)ncc1C(F)(F)F CHEMBL3921299 Ki 0.96 nM
CC(C)N1CCN(c2cc(-c3n[nH]c4ccc(-c5cn[nH]c5)cc34)ncn2)CC1 CHEMBL3915861 IC50 0.96 nM
CCNc1nc(Nc2cn(C3(C)COC3)nc2C)ncc1C(F)(F)F CHEMBL3943790 Ki 0.975 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(CCOCCOCCOCCOc6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ncn4)c3c2)CC1 CHEMBL5419763 IC50 0.98 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2171745 Ki 1.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1Br CHEMBL2171743 Ki 1.0 nM
CCNc1nc(Nc2cc(F)c(C(=O)NCC(C)(C)O)cc2OC)ncc1C(F)(F)F CHEMBL2178140 Ki 1.0 nM
COc1cc(C(=O)N2CCOCC2)c(F)cc1Nc1ncc(C(F)(F)F)c(NC2CC2)n1 CHEMBL2178135 Ki 1.0 nM
CCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2178134 Ki 1.0 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2178125 Ki 1.0 nM
CC(C)Nc1c(C(N)=O)nnc2ccc(-c3cn[nH]c3)cc12 CHEMBL2333115 IC50 1.0 nM
C[C@@H](Nc1c(C(N)=O)nnc2cc(-c3ccc(S(C)(=O)=O)cc3)ccc12)C1CC1 CHEMBL2333128 IC50 1.0 nM
CC[C@@H](C)Nc1c(C(N)=O)nnc2cc(-c3ccc(S(C)(=O)=O)cc3)ccc12 CHEMBL2333127 IC50 1.0 nM
CNc1nc(Nc2cnn(C(C)(C)C#N)c2C)ncc1C(F)(F)F CHEMBL3122114 Ki 1.0 nM
CNc1nc(Nc2ccc(-c3ccnn3C)cc2OC)ncc1C(F)(F)F CHEMBL3681029 Ki 1.0 nM
CNc1nc(Nc2ccc(-c3c(C)noc3C)cc2OC)ncc1C(F)(F)F CHEMBL3681030 Ki 1.0 nM
CNc1nc(Nc2cc(F)c(-c3cnn(C)c3C(=O)N(C)C)cc2OC)ncc1C(F)(F)F CHEMBL3681045 Ki 1.0 nM
CNc1nc(Nc2cc(C)c(-n3nnnc3C)cc2OC)ncc1C(F)(F)F CHEMBL3681049 Ki 1.0 nM
CNc1nc(Nc2cc(C)c(-n3nnnc3COC)cc2OC)ncc1C(F)(F)F CHEMBL3681050 Ki 1.0 nM
CNc1nc(Nc2cc3c(cc2OC)N(C)C(=O)C(C)(C)O3)ncc1Cl CHEMBL3694795 Ki 1.0 nM
CNc1nc(Nc2cc3oc(C(=O)N(C)C)cc3cc2OC)ncc1C(F)(F)F CHEMBL3694796 Ki 1.0 nM
CNc1nc(Nc2cc3c(cc2Cl)C(=O)N(C)C3)ncc1C(F)(F)F CHEMBL3694802 Ki 1.0 nM
CNc1nc(Nc2ccc3c(c2OC)CN(C)C3=O)ncc1C(F)(F)F CHEMBL3694804 Ki 1.0 nM
CCNc1nc(Nc2cc3c(cc2Cl)c(C(=O)N2CCOCC2)cn3C)ncc1C(F)(F)F CHEMBL3694820 Ki 1.0 nM
CNc1nc(Nc2cc3c(cc2OC)c(C(=O)N2CCOCC2)cn3C)ncc1C(F)(F)F CHEMBL3694821 Ki 1.0 nM
CNc1nc(Nc2cc3c(cc2Cl)c(C(=O)N2CCN(C)CC2)cn3C)ncc1C(F)(F)F CHEMBL3694822 Ki 1.0 nM
CCN1CCN(C(=O)c2cn(C)c3cc(Nc4ncc(C(F)(F)F)c(NC)n4)c(Cl)cc23)CC1 CHEMBL3694823 Ki 1.0 nM
CNc1nc(Nc2cc(Cl)c(S(C)(=O)=O)cc2OC)ncc1C(F)(F)F CHEMBL3985168 Ki 1.0 nM
Cc1cc(-c2cc(Nc3ccn(C)n3)nc3[nH]cc(C#N)c23)ccc1CN1CCOCC1 CHEMBL3980700 IC50 1.0 nM
C[C@H]1CN(c2cc(-n3ncc4ccc(C5(C#N)CC6(CC6)C5)cc43)ncn2)CCN1C1COC1 CHEMBL4450014 IC50 1.0 nM
CC1(O)CC2(CN(c3cc(-n4ncc5ccc(C6(C#N)CC7(CC7)C6)cc54)ncn3)C2)C1 CHEMBL4559776 IC50 1.0 nM
Cc1nn(C)cc1Nc1nc(N)c2c(C#N)c(N3CCC[C@H]3C)n(C)c2n1 CHEMBL5083563 Ki 1.0 nM
Cc1n[nH]cc1Nc1nc(N)c2c(C#N)c(N3CCC[C@H]3C)n(C)c2n1 CHEMBL5073900 Ki 1.0 nM
Cc1c(Nc2ncc3cccc(C4CC4)c3n2)cnn1C1CCOCC1 CHEMBL5089933 IC50 1.0 nM
Cn1cc(-c2cccc(C(=O)Nc3cc(N4CC[C@@H](C(C)(C)O)C4)ncc3C(F)(F)F)n2)cn1 CHEMBL5180782 IC50 1.0 nM
Cc1cc(-c2n[nH]c3ccc(Nc4ccccc4C#N)cc23)ccn1 CHEMBL5187271 IC50 1.0 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(N5CCOCC5)c4)c3c2)[C@H](C)n2nnnc2N1C CHEMBL5289675 IC50 1.0 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ncn4)c3c2)CC1 CHEMBL4759913 IC50 1.0 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ncn4)c3c2)CC1 CHEMBL4752225 IC50 1.0 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ncn4)c3c2)CC1 CHEMBL4740433 IC50 1.0 nM
C[C@H](C(F)F)n1cc(Nc2ncc3cc(C#N)n([C@H]4COC[C@@H]4C)c3n2)c(OC2COC2)n1 CHEMBL5410445 IC50 1.0 nM
N#Cc1ccc2c(c1)CC[C@@H]2Nc1ccc2[nH]nc(-c3cnoc3)c2c1 CHEMBL5393834 IC50 1.0 nM
Cn1cc(-c2cccc(C(=O)Nc3cc(N4CCC(C(C)(C)O)C4)ncc3C(F)(F)F)n2)cn1 CHEMBL5432835 IC50 1.0 nM
CNc1nc(Nc2ccc(C(=O)NC3CCC(F)(F)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3643969 Ki 1.1 nM
CCNc1nc(Nc2cn(C(C)(C)c3ncn(CC)n3)nc2Cl)ncc1C(F)(F)F CHEMBL3930752 Ki 1.1 nM
CCNc1nc(Nc2cnn(C(C)(C)c3nncn3C)c2Cl)ncc1C(F)(F)F CHEMBL3957757 Ki 1.1 nM
Cc1[nH]nc(-c2ccnc(N3CCOCC3)c2)c1-c1ccc(-c2cccc(S(N)(=O)=O)c2)cc1 CHEMBL5177578 IC50 1.1 nM
N#Cc1ccc2c(c1)CCC[C@@H]2Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5169946 IC50 1.1 nM
CCNc1nc(Nc2cnn3c2C(C)OCC3)ncc1C(F)(F)F CHEMBL3966065 Ki 1.2 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C)[C@@H](C)C4)ncn3)n[nH]c2cc1F CHEMBL3921084 IC50 1.2 nM
Cc1ncc(/C=C2\C(=O)Nc3ccc(OC(C)C)cc32)[nH]1 CHEMBL4093670 IC50 1.2 nM
CC(C)n1cc(-c2n[nH]c3ccnc(NC4CCOCC4)c23)nn1 CHEMBL4441650 Ki 1.2 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(N5CCOCC5)c4)c3c2)[C@@H](C)n2nnnc2N1C CHEMBL5281154 IC50 1.2 nM
Cc1cc(-c2n[nH]c(C)c2-c2cc(F)c(N3CCC4(CCS(=O)(=O)CC4)C3)c(F)c2)ccn1 CHEMBL5405161 IC50 1.2 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 1.259 nM
COc1ccncc1-c1ccc2[nH]nc(-c3cc(N4CCN(C(C)C)CC4)ncn3)c2c1 CHEMBL3938243 IC50 1.26 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL4303382 IC50 1.28 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C)[C@H](C)C4)ncn3)n[nH]c2cc1F CHEMBL4113352 IC50 1.3 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL2397014 IC50 1.3 nM
CC(C)(O)[C@@H]1CCN(c2cnc(C(F)(F)F)c(NC(=O)c3cccc(-c4cnn(C5CCC5)c4)n3)c2)C1 CHEMBL5197339 IC50 1.3 nM
CC(C)Oc1cc2c(-c3cc(N4C[C@@H](C)N(C)[C@@H](C)C4)ncn3)n[nH]c2cc1F CHEMBL3918740 IC50 1.33 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cn[nH]c5)cc34)ncn2)C[C@H](C)O1 CHEMBL3981433 IC50 1.35 nM
CCNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2F)ncc1C(F)(F)F CHEMBL3641895 Ki 1.4 nM
CCNc1nc(Nc2cc(F)c(C(=O)N(CC)CCOC)cc2OC)ncc1C(F)(F)F CHEMBL3643988 Ki 1.4 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)C[C@H](C)O1 CHEMBL3944061 IC50 1.4 nM
N#Cc1ccc2c(c1)CCC[C@@H]2Oc1ccc2[nH]nc(-c3ccnc(N4CCOCC4)c3)c2c1 CHEMBL5418512 IC50 1.4 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(-c5ccn[nH]5)cc34)ncn2)C[C@H](C)O1 CHEMBL3957927 IC50 1.44 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(NC2CCC2)n1 CHEMBL3641806 Ki 1.5 nM
CNc1nc(Nc2cc(OC)c(C(=O)NC3CCN(C)CC3)cc2Cl)ncc1C(F)(F)F CHEMBL3641847 Ki 1.5 nM
CNc1nc(Nc2ccc(C(=O)N3CC(F)(F)C3)cc2OC)ncc1C(F)(F)F CHEMBL3643957 Ki 1.5 nM
COCCn1cc(-c2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)cn1 CHEMBL3922699 IC50 1.5 nM
C[C@H]1CN(c2cc(NC(=O)c3cccc(-c4cnn(C)c4)n3)c(C(F)(F)F)cn2)CCN1C1COC1 CHEMBL5193374 IC50 1.5 nM
C[C@@H]1CN(c2cc(NC(=O)c3cccc(-c4cnn(C)c4)n3)c(C(F)(F)F)cn2)C[C@H](C)O1 CHEMBL5187531 IC50 1.5 nM
COc1ccncc1-c1ccc2[nH]nc(-c3cc(N4CCN(S(C)(=O)=O)CC4)ncn3)c2c1 CHEMBL3955660 IC50 1.58 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(OC)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3639428 Ki 1.6 nM
CCNc1nc(Nc2cc(F)c(C(=O)N(C)CCOC)cc2OC)ncc1C(F)(F)F CHEMBL3643985 Ki 1.6 nM
N#Cc1ccc2c(c1)CCC[C@@H]2Nc1ccc2[nH]nc(-c3ccnc(N4CCOCC4)c3)c2c1 CHEMBL5194735 IC50 1.6 nM
COCCN1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1=O CHEMBL3934167 IC50 1.63 nM
CC1(C)CC(=O)C=C(c2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)C1 CHEMBL3972368 IC50 1.63 nM
O=C1C=C(c2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)CCC1 CHEMBL3910233 IC50 1.63 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)[C@@H](C)n2nnnc2N1C CHEMBL5289513 IC50 1.64 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(CCO)CC4)ncn3)n[nH]c2cc1F CHEMBL3929129 IC50 1.65 nM
CNc1nc(Nc2ccc(C(=O)N3CC4CCC(C3)O4)cc2OC)ncc1C(F)(F)F CHEMBL3643959 Ki 1.7 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(C#N)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3643965 Ki 1.7 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4C[C@@H](C)O[C@@H](C)C4)ncn3)c2c1 CHEMBL3912556 IC50 1.7 nM
Cc1c(Nc2ncc3ccc(-c4ccn[nH]4)cc3n2)cnn1C1CCOCC1 CHEMBL5073735 IC50 1.7 nM
N#CC1(c2ccc3cnc(Nc4cnn(C5CCOCC5)c4Cl)nc3c2)CC12CC2 CHEMBL5088471 fIC50 1.7 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccccc4)c3c2)C(C)(C)n2nnnc2N1C CHEMBL5280373 IC50 1.7 nM
COc1ccncc1-c1ccc2[nH]nc(-c3cc(N4CCOCC4)ncn3)c2c1 CHEMBL3960072 IC50 1.72 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(NCCC2CC2)n1 CHEMBL3641816 Ki 1.8 nM
CNc1nc(Nc2cc(F)c(C(=O)N3CCC(C#N)C3)cc2OC)ncc1C(F)(F)F CHEMBL3641852 Ki 1.8 nM
CCNc1nc(Nc2ccc(C(=O)N3CCOCC3)c(F)c2OC)ncc1C(F)(F)F CHEMBL3641897 Ki 1.8 nM
CNc1nc(Nc2cnn3c2C(C)OC(C)C3)ncc1C(F)(F)F CHEMBL3974581 Ki 1.8 nM
COCCn1cc(-c2ccc3[nH]nc(-c4cc(N5C[C@@H](C)O[C@@H](C)C5)ncn4)c3c2)cn1 CHEMBL3915706 IC50 1.8 nM
CNc1nc(Nc2cn(S(=O)(=O)CCOC)nc2C)ncc1C(F)(F)F CHEMBL3952527 Ki 1.85 nM
COCCOC1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CC1 CHEMBL3931593 IC50 1.87 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CCO1 CHEMBL4110232 IC50 1.9 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)CC1 CHEMBL4066983 IC50 1.9 nM
FC1CN(C2COCC2F)CCC1c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl CHEMBL5079796 fIC50 1.9 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 1.995 nM
CNc1nc(Nc2cc(F)c(S(C)(=O)=O)cc2OC)ncc1C(F)(F)F CHEMBL2178137 Ki 2.0 nM
CNc1nc(Nc2cc(C)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2178130 Ki 2.0 nM
CNc1nc(Nc2cc(Cl)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2178124 Ki 2.0 nM
CNc1nc(Nc2cnn(CCOC)c2C)ncc1C(F)(F)F CHEMBL2326721 Ki(app) 2.0 nM
CCn1ncc(Nc2ncc(C(F)(F)F)c(NC)n2)c1C CHEMBL2326717 Ki(app) 2.0 nM
CNc1nc(Nc2cnn(C)c2C)ncc1C(F)(F)F CHEMBL2326714 Ki(app) 2.0 nM
C[C@@H](Nc1c(C(N)=O)nnc2cc(-c3ccncc3)ccc12)C1CC1 CHEMBL2333113 IC50 2.0 nM
CNc1nc(Nc2cnn([C@H]3CCN(C4COC4)C[C@@H]3F)c2Cl)ncc1C(F)(F)F CHEMBL3122117 Ki 2.0 nM
CNc1nc(Nc2cn([C@H]3CCN(C4COC4)C[C@H]3F)nc2C)ncc1C(F)(F)F CHEMBL3122116 Ki 2.0 nM
CNc1nc(Nc2cnn(C3CCOCC3)c2C)ncc1C(F)(F)F CHEMBL3122121 Ki 2.0 nM
CNc1nc(Nc2cnn(C3COC3)c2C)ncc1C(F)(F)F CHEMBL3122120 Ki 2.0 nM
CNc1nc(Nc2cnn(C3(C#N)CC3)c2Cl)ncc1C(F)(F)F CHEMBL3122118 Ki 2.0 nM
CNc1nc(Nc2ccc(-c3cncn3C)cc2OC)ncc1C(F)(F)F CHEMBL3676113 Ki 2.0 nM
CNc1nc(Nc2ccc(-c3cncn3C)cc2OC)ncc1Cl CHEMBL3676118 Ki 2.0 nM
CNc1nc(Nc2ccc(-c3cnnn3C)cc2OC)ncc1C(F)(F)F CHEMBL3676119 Ki 2.0 nM
CNc1nc(Nc2ccc(-n3cnnn3)cc2OC)ncc1C(F)(F)F CHEMBL3681031 Ki 2.0 nM
CNc1nc(Nc2ccc(-c3cnn(C)c3)cc2OC)ncc1Cl CHEMBL3681039 Ki 2.0 nM
CNc1nc(Nc2ccc(-c3cn(C)nc3C)cc2OC)ncc1C(F)(F)F CHEMBL3681042 Ki 2.0 nM
CNc1nc(Nc2ccc(-c3nncn3C)cc2OC)ncc1C(F)(F)F CHEMBL3681044 Ki 2.0 nM
CNc1nc(Nc2cc(F)c(-c3cnnn3C)cc2OC)ncc1C(F)(F)F CHEMBL3681047 Ki 2.0 nM
CNc1nc(Nc2cc3c(cc2Cl)n(C)c(=O)n3C)ncc1C(F)(F)F CHEMBL3694797 Ki 2.0 nM
CNc1nc(Nc2cc3oc(=O)n(C)c3cc2Cl)ncc1C(F)(F)F CHEMBL3694798 Ki 2.0 nM
CCNc1nc(Nc2cc3c(cc2OC)C(=O)N(C2COC2)C3)ncc1C(F)(F)F CHEMBL3694817 Ki 2.0 nM
CNc1nc(Nc2ccc(C(=O)NC(C)C)cc2OC)ncc1Cl CHEMBL3641788 Ki 2.0 nM
CNc1nc(Nc2ccc(C(=O)N3CC4CCC(C3)O4)cc2OC)ncc1Cl CHEMBL3641791 Ki 2.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC2CC2)ncc1Cl CHEMBL3641881 Ki 2.0 nM
CCNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL3641907 Ki 2.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3643966 Ki 2.0 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2Cl)ncc1C(F)(F)F CHEMBL2178126 Ki 2.0 nM
CNc1nc(Nc2ccc(S(C)(=O)=O)cc2OC)ncc1C(F)(F)F CHEMBL3942852 Ki 2.0 nM
CNc1nc(Nc2ccc(S(C)(=O)=O)cc2OC)ncc1Cl CHEMBL3968761 Ki 2.0 nM
CCNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OCCF)ncc1C(F)(F)F CHEMBL3980168 Ki 2.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1F CHEMBL3393356 IC50 2.0 nM
CNc1nc(Nc2cnn(CCc3ccn(C)n3)c2C)ncc1C(F)(F)F CHEMBL3928518 Ki 2.0 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)CCO1 CHEMBL4065697 IC50 2.0 nM
CC(C)n1cc(-c2n[nH]c3ccnc(OC4CCCCC4)c23)cn1 CHEMBL4444153 IC50 2.0 nM
Cc1c(Nc2nc(N)c3c(C#N)c(N4CCC[C@H]4C)n(C)c3n2)cnn1C CHEMBL5089194 Ki 2.0 nM
C[C@@H]1[C@@H](O)CN1c1cc(NC(=O)c2cccc(-c3cnn(C)c3)n2)c(C(F)(F)F)cn1 CHEMBL5190434 IC50 2.0 nM
Cn1cc(-c2cccc(C(=O)Nc3cc(N4CC5(C(C)(C)O)CC4C5)ncc3C(F)(F)F)n2)cn1 CHEMBL5202285 IC50 2.0 nM
N#Cc1cccc(F)c1Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5206337 IC50 2.0 nM
Cc1cc(-c2n[nH]c3ccc(Nc4ccc(C#N)cc4C#N)cc23)ccn1 CHEMBL5170359 IC50 2.0 nM
N#Cc1ccc2c(c1)CCC[C@H]2Nc1ccc2[nH]nc(-c3ccnc(N4CCOCC4)c3)c2c1 CHEMBL5182227 IC50 2.0 nM
C[C@H]1CC1(C#N)c1ccc2cnn(-c3cc(N4CC5(C(C)(C)O)CC4C5)ncn3)c2c1 CHEMBL5267690 IC50 2.0 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCOCCNc6cccc7c6C(=O)N(C6CCCNC6=O)C7=O)CC5)ncn4)c3c2)CC1 CHEMBL5429152 IC50 2.0 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7)CC5)ncn4)c3c2)CC1 CHEMBL4748288 IC50 2.0 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7)CC5)ncn4)c3c2)CC1 CHEMBL4749032 IC50 2.0 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCOC6(CC6)C5)ncn4)c3c2)cn1 CHEMBL3917197 IC50 2.01 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CCCO5)CC4)ncn3)c2c1 CHEMBL3903923 IC50 2.02 nM
COC1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CC1 CHEMBL3970173 IC50 2.04 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C)CC4)ncn3)c2c1 CHEMBL3907065 IC50 2.08 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(I)c(OC)n1 CHEMBL3641815 Ki 2.1 nM
CCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OCC)ncc1C(F)(F)F CHEMBL3643990 Ki 2.1 nM
COCCOC1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1 CHEMBL3919816 IC50 2.1 nM
FC1(F)CCN(c2cc(-c3n[nH]c4ccc(-c5cc[nH]n5)cc34)ncn2)CC1 CHEMBL3927749 IC50 2.16 nM
[2H]C([2H])([2H])c1cnc(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@@H]2CCO[C@H](C)C2)cn1 CHEMBL4451151 IC50 2.16 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(c5cnn(C)c5)CC4)ncn3)n[nH]c2cc1F CHEMBL3919519 IC50 2.19 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C)C(=O)C4)ncn3)n[nH]c2cc1F CHEMBL3906191 IC50 2.19 nM
CNc1nc(Nc2ccc(C(=O)N3CCN(C(=O)C4CC4)CC3)cc2OC)ncc1Cl CHEMBL3641795 Ki 2.2 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCCC(F)(F)C5)ncn4)c3c2)cn1 CHEMBL3939048 IC50 2.2 nM
C[C@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CCO1 CHEMBL3909904 IC50 2.2 nM
Cc1cncc(-c2ccc3[nH]nc(-c4cc(N5C[C@@H](C)O[C@@H](C)C5)ncn4)c3c2)c1 CHEMBL3958879 IC50 2.2 nM
Cc1ncc(-c2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)s1 CHEMBL3942757 IC50 2.2 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(S(C)(=O)=O)CC5)ncn4)c3c2)CC1 CHEMBL4093321 IC50 2.2 nM
CCc1cc(-c2c(-c3ccncc3)n[nH]c2C)ccc1-c1cccc(S(N)(=O)=O)c1 CHEMBL5170238 IC50 2.2 nM
CCS(=O)(=O)N1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1 CHEMBL3897231 IC50 2.24 nM
CNc1nc(Nc2ccc(C(=O)NCCCN)cc2OC)ncc1Cl CHEMBL3641792 Ki 2.3 nM
CNc1nc(Nc2ccc(C(=O)N3CCN(C4CCC4)CC3)cc2OC)ncc1Br CHEMBL3641799 Ki 2.3 nM
CNc1nc(Nc2ccc(C(=O)NCCOC)cc2OC)ncc1C(F)(F)F CHEMBL3643967 Ki 2.3 nM
CCNc1nc(Nc2ccc(C(=O)N(C)CCOC)cc2OC)ncc1C(F)(F)F CHEMBL3643983 Ki 2.3 nM
CNc1nc(Nc2cnn3c2COCC3)ncc1C(F)(F)F CHEMBL3122106 Ki 2.3 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CC[C@@H](CF)C5)ncn4)c3c2)cn1 CHEMBL3944448 IC50 2.3 nM
CC(O)C1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)C1 CHEMBL3925366 IC50 2.3 nM
CC(C)Oc1cc2c(-c3cc(N4CCC(F)(CO)CC4)ncn3)n[nH]c2cc1F CHEMBL3958420 IC50 2.3 nM
c1nc(-c2n[nH]c3ccc(-c4cn[nH]c4)cc23)cc(N2CCOCC2)n1 CHEMBL3963291 IC50 2.3 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)cn1 CHEMBL3979762 IC50 2.31 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CCNC5=O)CC4)ncn3)c2c1 CHEMBL3932625 IC50 2.31 nM
CC(C)N1CCN(c2cc(-c3n[nH]c4ccc(-c5ccn[nH]5)cc34)ncn2)CC1 CHEMBL3943811 IC50 2.34 nM
CC(C)Oc1cc2c(-c3cc(N4CCOCC4)ncn3)n[nH]c2cc1F CHEMBL3935320 IC50 2.39 nM
CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)NC4COC4)n(C(C)C)c3)c12 CHEMBL2152708 Ki 2.4 nM
CNc1nc(Nc2ccc(C(=O)NC3CC3)cc2OC)ncc1Cl CHEMBL3641770 Ki 2.4 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(C(C)(C)O)CC3)cc2OC)ncc1Br CHEMBL3641796 Ki 2.4 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(OC)CC3)cc2OC)ncc1Br CHEMBL3641801 Ki 2.4 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(NC2(C)CCC2)n1 CHEMBL3641813 Ki 2.4 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OCCF)ncc1C(F)(F)F CHEMBL3643951 Ki 2.4 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1C#N CHEMBL2171746 Ki 2.4 nM
COc1cncc(-c2ccc3[nH]nc(-c4cc(N5C[C@@H](C)O[C@@H](C)C5)ncn4)c3c2)n1 CHEMBL3960093 IC50 2.4 nM
Cc1cc(-c2n[nH]c(C)c2-c2ccc(-c3cccc(S(N)(=O)=O)c3)c(C3CC3)c2)ccn1 CHEMBL5181966 IC50 2.4 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(Br)c3c2)Cn2nnnc2N1C CHEMBL5271931 IC50 2.4 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 2.5 nM
CNc1nc(Nc2ccc(C(=O)N3CCCCC3)cc2OC)ncc1Cl CHEMBL3641774 Ki 2.5 nM
CNc1nc(Nc2ccc(C(=O)N3C4CCC3COC4)cc2OC)ncc1Cl CHEMBL3639406 Ki 2.5 nM
CCN1CCN(C(=O)c2ccc(Nc3ncc(Br)c(OC)n3)c(OC)c2)CC1 CHEMBL3641808 Ki 2.5 nM
CCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1Cl CHEMBL3641810 Ki 2.5 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC2CC2)ncc1Br CHEMBL3641882 Ki 2.5 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC2CCC2)ncc1C(F)(F)F CHEMBL3643956 Ki 2.5 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CC[C@H](CO)C5)ncn4)c3c2)cn1 CHEMBL3900844 IC50 2.5 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C5CCS(=O)(=O)C5)CC4)ncn3)n[nH]c2cc1F CHEMBL3919113 IC50 2.5 nM
FC1CN(C2CCOC2)CCC1c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl CHEMBL5070497 fIC50 2.5 nM
Cc1[nH]nc(-c2ccncc2)c1-c1ccc(N2CCC3(CCS(=O)(=O)CC3)C2)c(C2CC2)c1 CHEMBL5394684 IC50 2.51 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 2.512 nM
Cc1n[nH]c(C)c1-c1ccc2[nH]nc(-c3cc(N4CCOCC4)ncn3)c2c1 CHEMBL3919142 IC50 2.58 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2Cl)ncc1Br CHEMBL3643973 Ki 2.6 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCOCC4)ncn3)c2c1 CHEMBL3917266 IC50 2.6 nM
CNc1nc(Nc2cnn3c2C(C)OCC3(C)C)ncc1C(F)(F)F CHEMBL3971593 Ki 2.6 nM
CO[C@H]1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)C1 CHEMBL3902073 IC50 2.6 nM
CC(C)Oc1ccc2[nH]nc(-c3ccnc(N4CCN(C)C(=O)C4)c3)c2c1 CHEMBL4075961 IC50 2.6 nM
CC(C)(O)C1CN(c2cc(-n3ncc4ccc(C5(C#N)CC6(CC6)C5)cc43)ncn2)C1 CHEMBL4562534 IC50 2.6 nM
Clc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1N1CCN(C2COC2)CC1 CHEMBL5085536 IC50 2.6 nM
Cc1c(Nc2ncc3cc(Cl)c(C4CCN([C@@H]5COC[C@@H]5O)CC4)cc3n2)cnn1[C@@H]1CC1(F)F CHEMBL5075047 fIC50 2.6 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)Cn2nnnc2N1c1ccccc1 CHEMBL5286615 IC50 2.6 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCN(C6CC6)CC5)ncn4)c3c2)cn1 CHEMBL3967256 IC50 2.62 nM
c1cc(-c2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)[nH]n1 CHEMBL3932649 IC50 2.63 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(NCC2CC2)n1 CHEMBL3641805 Ki 2.7 nM
CNc1nc(Nc2ccc(C(=O)N3CC(N4CCOCC4)C3)cc2OC)ncc1Cl CHEMBL3641812 Ki 2.7 nM
CNc1nc(Nc2cc(F)c(C(=O)N3CCC(OC)C3)cc2OC)ncc1C(F)(F)F CHEMBL3641901 Ki 2.7 nM
CNc1nc(Nc2cc(Cl)c(C(=O)N3CCOCC3)cc2OC)ncc1Cl CHEMBL3643977 Ki 2.7 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCc6nccnc6C5)ncn4)c3c2)cn1 CHEMBL3964035 IC50 2.7 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@@H](CF)C4)ncn3)c2c1 CHEMBL3950303 IC50 2.7 nM
CC(C)Oc1ccc2[nH]nc(-c3ccnc(N4CCN(S(C)(=O)=O)CC4)c3)c2c1 CHEMBL4065525 IC50 2.7 nM
CCCN1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1=O CHEMBL3891762 IC50 2.77 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCO[C@H](C)C4)ncn3)c2c1 CHEMBL4114340 IC50 2.79 nM
CNc1nc(Nc2ccc(C(=O)N3CCCC(C(F)(F)F)C3)cc2OC)ncc1Cl CHEMBL3641778 Ki 2.8 nM
CNc1nc(Nc2ccc(C(=O)N3CCNCC3)cc2OC)ncc1Cl CHEMBL3641785 Ki 2.8 nM
COc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC2CCC2)ncc1Br CHEMBL3641809 Ki 2.8 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(N(C)C)CC3)cc2Cl)ncc1Cl CHEMBL3641830 Ki 2.8 nM
CCNc1nc(Nc2ccc(C(=O)N3C[C@@H]4C[C@H]3CO4)c(F)c2OC)ncc1C(F)(F)F CHEMBL3641898 Ki 2.8 nM
CNc1nc(Nc2cnn(C3CCOC[C@H]3F)c2C)ncc1C(F)(F)F CHEMBL4112787 Ki 2.8 nM
Cc1nc2c(o1)CCN(c1cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn1)C2 CHEMBL3895725 IC50 2.8 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCCC(F)(F)C4)ncn3)c2c1 CHEMBL3922591 IC50 2.8 nM
COC1CN(c2cc(NC(=O)c3cccc(-c4cnn(C)c4)n3)c(C(F)(F)F)cn2)C1 CHEMBL5172722 IC50 2.8 nM
Cc1n[nH]c2ccc(O[C@H]3CCCc4cc(C#N)ccc43)cc12 CHEMBL5435861 IC50 2.8 nM
C[C@@]1(N2CCC(c3cc4cc(NC(=O)C5CC56CC6)ncc4cc3Cl)CC2)COC[C@@H]1O CHEMBL5396961 fIC50 2.8 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CCNC5=O)CC4)ncn3)c2c1 CHEMBL3939653 IC50 2.83 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCNC(=O)C5)ncn4)c3c2)cn1 CHEMBL3981561 IC50 2.84 nM
CN1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CC1 CHEMBL3922655 IC50 2.85 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CC4)CNC(=O)C5)ncn3)c2c1 CHEMBL3893371 IC50 2.85 nM
CC(C)Oc1cc2c(-c3cc(N4CCO[C@H](C)C4)ncn3)n[nH]c2cc1F CHEMBL4113861 IC50 2.87 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CC4)CC(=O)N(C)C5)ncn3)c2c1 CHEMBL3930335 IC50 2.87 nM
CC(C)Oc1cc2c(-c3cc(N4C[C@@H](C)O[C@@H](C)C4)ncn3)n[nH]c2cc1F CHEMBL3914976 IC50 2.89 nM
CC(C)Oc1cc2c(-c3cc(N4CCNC(=O)C4)ncn3)n[nH]c2cc1F CHEMBL3959858 IC50 2.89 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(C#N)C3)cc2Cl)ncc1C(F)(F)F CHEMBL3641851 Ki 2.9 nM
CNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2178133 Ki 2.9 nM
CNc1nc(Nc2cn(C(C)(C)c3ncn(C)n3)nc2Cl)ncc1C(F)(F)F CHEMBL3893817 Ki 2.9 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CC[C@@H](CO)C5)ncn4)c3c2)cn1 CHEMBL4113045 IC50 2.9 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCC(F)(CO)CC5)ncn4)c3c2)cn1 CHEMBL3962905 IC50 2.9 nM
CC(C)Oc1cc2c(-c3cc(N4CC[C@@H](CO)C4)ncn3)n[nH]c2cc1F CHEMBL4106457 IC50 2.9 nM
COCC1CN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CCO1 CHEMBL3897235 IC50 2.9 nM
NS(=O)(=O)c1cccc(-c2ccc(-c3c[nH]nc3-c3ccnc(N4CCOCC4)c3)cc2)c1 CHEMBL5173029 IC50 2.9 nM
CCN1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1 CHEMBL3927721 IC50 2.97 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C(=O)C5CC5)CC4)ncn3)n[nH]c2cc1F CHEMBL3902480 IC50 2.98 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1Cl CHEMBL2170016 Ki 3.0 nM
CCNc1nc(Nc2cnc(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2178138 Ki 3.0 nM
CCNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2Cl)ncc1C(F)(F)F CHEMBL2178127 Ki 3.0 nM
CNc1nc(Nc2cnn(CC(C)(C)C#N)c2C)ncc1C(F)(F)F CHEMBL2326724 Ki(app) 3.0 nM
CNc1nc(Nc2cnn(C(C)C)c2C)ncc1C(F)(F)F CHEMBL2326719 Ki(app) 3.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403370 IC50 3.0 nM
CNc1nc(Nc2cn(C3(C#N)CC3)nc2C)ncc1C(F)(F)F CHEMBL3122115 Ki 3.0 nM
CNc1nc(Nc2cnn3c2C(C)OCC3)ncc1C(F)(F)F CHEMBL3122108 Ki 3.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 CHEMBL3393348 IC50 3.0 nM
CC(C)n1cc(-c2n[nH]c3ccnc(OC4CCOCC4)c23)cc1C(=O)NC1COC1 CHEMBL3651747 Ki 3.0 nM
c1cc(-c2n[nH]c3ccnc(OC4CCOCC4)c23)cc(N2CCCC2)n1 CHEMBL3651766 Ki 3.0 nM
c1cc2[nH]nc(-c3cnn([C@H]4CCOC4)c3)c2c(OC2CCOCC2)n1 CHEMBL3651789 Ki 3.0 nM
CNc1nc(Nc2ccc(-c3nnn[nH]3)cc2Cl)ncc1C(F)(F)F CHEMBL3676107 Ki 3.0 nM
CNc1nc(Nc2ccc(-n3cncn3)cc2OC)ncc1C(F)(F)F CHEMBL3676109 Ki 3.0 nM
CNc1nc(Nc2cc(OC)c(-c3nccn3C)cc2Cl)ncc1C(F)(F)F CHEMBL3676121 Ki 3.0 nM
CNc1nc(Nc2ccc(-c3nnnn3C)cc2OC)ncc1C(F)(F)F CHEMBL3676122 Ki 3.0 nM
CNc1nc(Nc2cc(OC)c(-c3cncn3C)cc2Cl)ncc1C(F)(F)F CHEMBL3676123 Ki 3.0 nM
CNc1nc(Nc2ccc(-c3cnnn3C)cc2OC)ncc1Cl CHEMBL3676125 Ki 3.0 nM
CNc1nc(Nc2cc(OC)c(-c3c(C)nn(C)c3C)cc2Cl)ncc1C(F)(F)F CHEMBL3681028 Ki 3.0 nM
CNc1nc(Nc2ccc(-c3cnn(C)c3C)cc2OC)ncc1C(F)(F)F CHEMBL3681043 Ki 3.0 nM
CNc1nc(Nc2cc(F)c(-n3nnnc3C)cc2OC)ncc1C(F)(F)F CHEMBL3681046 Ki 3.0 nM
CNc1nc(Nc2cc3c(cc2Cl)C(=O)N(C)CCO3)ncc1C(F)(F)F CHEMBL3694794 Ki 3.0 nM
CNc1nc(Nc2cc3c(cc2Cl)C(=O)N(C)C3)ncc1Cl CHEMBL3694801 Ki 3.0 nM
CNc1nc(Nc2cc3c(cc2Cl)c(C(=O)N2CCOCC2)cn3C)ncc1C(F)(F)F CHEMBL3694814 Ki 3.0 nM
CCNc1nc(Nc2cc3c(cc2OC)C(=O)N(CC(C)(C)O)C3)ncc1C(F)(F)F CHEMBL2178141 Ki 3.0 nM
CNc1nc(Nc2cc3c(cc2Cl)c(C(=O)N2C[C@@H]4C[C@H]2CO4)cn3C)ncc1C(F)(F)F CHEMBL3694824 Ki 3.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(F)(F)CC3)cc2OC)ncc1Cl CHEMBL3641776 Ki 3.0 nM
CNc1nc(Nc2cc(F)c(C(=O)N3CCC[C@H]3COC)cc2OC)ncc1C(F)(F)F CHEMBL3643986 Ki 3.0 nM
CNc1nc(Nc2ccc(CN3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL3954199 Ki 3.0 nM
CNc1nc(Nc2ccc(S(C)(=O)=O)cc2OCCF)ncc1C(F)(F)F CHEMBL3956503 Ki 3.0 nM
CNc1nc(Nc2cc(F)c(N3CCCC3=O)cc2OC)ncc1C(F)(F)F CHEMBL3968101 Ki 3.0 nM
CNc1nc(Nc2cc(F)c(N3CCOCC3=O)cc2OC)ncc1C(F)(F)F CHEMBL3901723 Ki 3.0 nM
CNc1nc(Nc2cc(F)c(C3COC3)cc2OC)ncc1C(F)(F)F CHEMBL3910723 Ki 3.0 nM
CCNc1nc(Nc2cc(C)c(S(C)(=O)=O)cc2OC)ncc1C(F)(F)F CHEMBL3980796 Ki 3.0 nM
CCS(=O)(=O)c1cc(OC)c(Nc2ncc(C(F)(F)F)c(NC)n2)cc1C CHEMBL3925454 Ki 3.0 nM
CCNc1nc(Nc2ccc(S(C)(=O)=O)c3c2OCCO3)ncc1C(F)(F)F CHEMBL3925653 Ki 3.0 nM
Cc1nn(C(C)(C)C#N)cc1Nc1ncc(C#N)c(NC2CC2)n1 CHEMBL3941549 Ki 3.0 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCN(CCCO)CC5)ncn4)c3c2)cn1 CHEMBL3897407 IC50 3.0 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCC(F)(C#N)CC5)ncn4)c3c2)cn1 CHEMBL3986234 IC50 3.0 nM
N#Cc1c[nH]c2nc(N)cc(-c3ccccc3)c12 CHEMBL3896115 Ki 3.0 nM
C[C@@H]1[C@H](O)CCN1c1cc(NC(=O)c2cccc(-c3cnn(C)c3)n2)c(C(F)(F)F)cn1 CHEMBL5169732 IC50 3.0 nM
COc1cc(-c2n[nH]c3ccc(Nc4ccccc4C#N)cc23)ccn1 CHEMBL5196967 IC50 3.0 nM
C[C@@H]1CN(c2cc(-c3ncn4ccc(-c5cnn(C)c5)cc34)ccn2)C[C@H](C)O1 CHEMBL5290520 IC50 3.0 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(NC(=O)c4ccccc4)c3c2)Cn2nnnc2N1C CHEMBL5288038 IC50 3.0 nM
CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7)CC5)ncn4)c3c2)CC1 CHEMBL4799229 IC50 3.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCC(=O)N2CCN(c3cc(-c4n[nH]c5ccc(OC6(C)CC6)cc45)ncn3)CC2)C(C)(C)C)cc1 CHEMBL5411054 IC50 3.0 nM
CC1(N2CCC(c3cc4cc(NC(=O)C5CC5)ncc4cc3Cl)CC2)COC1 CHEMBL5407847 IC50 3.0 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(S(C)(=O)=O)CC4)ncn3)n[nH]c2cc1F CHEMBL3904862 IC50 3.09 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C(C)C)C(=O)C4)ncn3)n[nH]c2cc1F CHEMBL3928726 IC50 3.09 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(CCCO)CC4)ncn3)n[nH]c2cc1F CHEMBL3926035 IC50 3.1 nM
c1ccc(-c2n[nH]c3ccnc(NC4CCOCC4)c23)nc1 CHEMBL4435096 Ki 3.1 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 3.1 nM
Cc1[nH]nc(-c2ccncc2)c1-c1ccc(-c2cccc(S(N)(=O)=O)c2)c(C2CC2)c1 CHEMBL5174380 IC50 3.1 nM
CC(=O)N1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CC1 CHEMBL3952812 IC50 3.15 nM
CCOc1nc(Nc2ccc(C(=O)N3CCN4CCC[C@H]4C3)cc2OC)nc2[nH]ccc12 CHEMBL4780638 pIC50 3.162 nM
CCNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC(F)(F)F)ncc1C(F)(F)F CHEMBL3641893 Ki 3.2 nM
Cc1n[nH]c(C)c1-c1ccc2[nH]nc(-c3cc(N4CCO[C@H](C)C4)ncn3)c2c1 CHEMBL4107421 IC50 3.2 nM
Cc1c(Nc2ncc3ccc(N4C(=O)OC[C@@H]4C)cc3n2)cnn1C1CCOCC1 CHEMBL5078277 fIC50 3.2 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCN(S(C)(=O)=O)CC5)ncn4)c3c2)cn1 CHEMBL3950786 IC50 3.28 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(C#N)CC3)cc2Cl)ncc1Cl CHEMBL3641842 Ki 3.3 nM
CNc1nc(Nc2ccc(C(=O)N3CCCCC3)cc2OC)ncc1C#N CHEMBL3641871 Ki 3.3 nM
CNc1nc(Nc2ccc(C(=O)N3CC4CC(C3)O4)cc2OC)ncc1C(F)(F)F CHEMBL3643960 Ki 3.3 nM
CCN(CC)C(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NC)n2)c(OC)c1 CHEMBL3643962 Ki 3.3 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(CCF)C(=O)C4)ncn3)c2c1 CHEMBL3908542 IC50 3.3 nM
Cc1cnn(Cc2nc3cnc4ccc(C#N)cc4c3n2C2CN(C)CC2(F)F)n1 CHEMBL4435423 IC50 3.31 nM
Cc1cnc(Cc2nc3cnc4ccc(C#N)cc4c3n2C2CN(C)CC2(F)F)cn1 CHEMBL4444592 IC50 3.31 nM
CNc1nc(Nc2ccc(C(=O)N3CCN(C(C)=O)CC3)cc2OC)ncc1Cl CHEMBL3641777 Ki 3.4 nM
CNc1nc(Nc2cc(OC)c(CC(=O)N3CCOCC3)cc2OC)ncc1Br CHEMBL3641884 Ki 3.4 nM
COc1cc(C(=O)N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C CHEMBL2012582 IC50 3.5 nM
CNc1nc(Nc2ccc(C(=O)N3CCN4CCCCC4C3)cc2OC)ncc1Cl CHEMBL3641772 Ki 3.5 nM
CCNc1nc(Nc2cc(OC)c(C(=O)NC3CC3)cc2Cl)ncc1C(F)(F)F CHEMBL3641827 Ki 3.5 nM
CCN(CCOC)C(=O)c1cc(OC)c(Nc2ncc(C(F)(F)F)c(NC)n2)cc1F CHEMBL3643989 Ki 3.5 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CC4)CNC(=O)CO5)ncn3)c2c1 CHEMBL3964216 IC50 3.5 nM
CCc1cc(-c2n[nH]c3ccnc(NC(C)C)c23)nn1C CHEMBL4560272 Ki 3.5 nM
N#Cc1ccc2c(c1)CCC[C@@H]2Oc1ccc2[nH]nc(-c3cnco3)c2c1 CHEMBL5430788 IC50 3.5 nM
CNc1nc(Nc2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)cc2OC)ncc1Cl CHEMBL3641781 Ki 3.6 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(O)CC3)cc2Cl)ncc1Cl CHEMBL3641838 Ki 3.6 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCC(n6cccn6)C5)ncn4)c3c2)cn1 CHEMBL3973863 IC50 3.6 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@@H](CO)C4)ncn3)c2c1 CHEMBL3980002 IC50 3.6 nM
COCC1CN(c2cc(-c3n[nH]c4ccc(O[C@@H](C)COC)cc34)ncn2)CCO1 CHEMBL3920769 IC50 3.6 nM
CNc1nc(Nc2cc(OC)c(CC(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL3641888 Ki 3.7 nM
CNc1nc(Nc2ccc(C(=O)NC3COC3)cc2OC)ncc1C(F)(F)F CHEMBL3643958 Ki 3.7 nM
CCNc1nc(Nc2cn(C(C)(C)c3nnc(C)o3)nc2Cl)ncc1C(F)(F)F CHEMBL3951315 Ki 3.7 nM
CNc1nc(Nc2cn(CCc3ccn(C)n3)nc2C)ncc1C(F)(F)F CHEMBL3957924 Ki 3.7 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCC(F)(F)C5)ncn4)c3c2)cn1 CHEMBL3957537 IC50 3.7 nM
Cc1c(Nc2nc(N)c3c(C#N)c(N4CCC[C@H]4C)n(C)c3n2)cnn1[C@@H]1CCOC1 CHEMBL5087055 Kd 3.7 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CCN(C)C5=O)CC4)ncn3)c2c1 CHEMBL3964546 IC50 3.71 nM
CNc1nc(Nc2ccc(C(=O)N3CCCC3C)cc2OC)ncc1Cl CHEMBL3641779 Ki 3.8 nM
CNc1nc(Nc2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)cc2OC)ncc1Br CHEMBL3641800 Ki 3.8 nM
CNc1nc(Nc2cc(OC)c(C(=O)NCCCN)cc2Cl)ncc1Cl CHEMBL3641889 Ki 3.8 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5C[C@H](F)[C@@H](F)C5)ncn4)c3c2)cn1 CHEMBL3894658 IC50 3.8 nM
C[C@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)CCO1 CHEMBL4082856 IC50 3.8 nM
CNc1nc(Nc2cn(C(C)(C)c3ncc(C)o3)nc2C)ncc1C(F)(F)F CHEMBL3915832 Ki 3.82 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C5CC5)CC4)ncn3)n[nH]c2cc1F CHEMBL3977672 IC50 3.99 nM
CNc1nc(Nc2cnn(C)c2Cl)ncc1C(F)(F)F CHEMBL2326715 Ki(app) 4.0 nM
CC(=O)N1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(OC(C)C)cc43)cc2C1 CHEMBL2403375 IC50 4.0 nM
CC(=O)Nc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403374 IC50 4.0 nM
CNc1nc(Nc2cnn(C3CCN(C4COC4)CC3)c2C)ncc1C(F)(F)F CHEMBL3122122 Ki 4.0 nM
CNc1nc(Nc2ccc(-c3cnn(C)c3)cc2OC)ncc1C(F)(F)F CHEMBL3676110 Ki 4.0 nM
CNc1nc(Nc2cc(OC)c(-c3cnnn3C)cc2Cl)ncc1C(F)(F)F CHEMBL3676115 Ki 4.0 nM
CNc1nc(Nc2cc(F)c(-n3nnnc3COC)cc2OC)ncc1C(F)(F)F CHEMBL3681053 Ki 4.0 nM
CNc1nc(Nc2cc3oc(=O)[nH]c3cc2Cl)ncc1Cl CHEMBL3694806 Ki 4.0 nM
CNc1nc(Nc2ccc3c(c2OC)CN(C(C)(C)O)C3=O)ncc1C(F)(F)F CHEMBL3694811 Ki 4.0 nM
CNc1nc(Nc2cc3c(cc2Cl)c(C(=O)N2CCNCC2)cn3C)ncc1C(F)(F)F CHEMBL3694819 Ki 4.0 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(NCC(C)C)n1 CHEMBL3641794 Ki 4.0 nM
CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OCCF)ncc1C(F)(F)F CHEMBL3947841 Ki 4.0 nM
CO[C@@H]1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)C1 CHEMBL4107947 IC50 4.0 nM
Cc1cccc(-c2ccnc3[nH]cc(C#N)c23)c1 CHEMBL3912951 Ki 4.0 nM
c1cc2[nH]nc(-c3cnn(C4CCCC4)c3)c2c(OC2CCOCC2)n1 CHEMBL3651739 IC50 4.0 nM
C[C@@H]1CCCN1c1[nH]c2ncnc(N)c2c1C#N CHEMBL5078779 Ki 4.0 nM
Cc1nc(NC(=O)c2cccc(-c3cnn(C)c3)n2)cc(N2CC[C@@H](C(C)(C)O)C2)n1 CHEMBL5171071 IC50 4.0 nM
Cc1cc(-c2n[nH]c(C)c2-c2ccc(-c3cccc(S(N)(=O)=O)c3)cc2)cc(C)n1 CHEMBL5179102 IC50 4.0 nM
O=[N+]([O-])c1ccccc1Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5179734 IC50 4.0 nM
N#Cc1ccccc1Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5176421 IC50 4.0 nM
Cc1cc(-c2n[nH]c3ccc(N[C@@H]4CCCc5cc(C#N)ccc54)cc23)cc(C)n1 CHEMBL5171585 IC50 4.0 nM
Cc1cc(-c2n[nH]c3ccc(N[C@@H]4CCOc5cc(C#N)ccc54)cc23)cc(C)n1 CHEMBL5208819 IC50 4.0 nM
N#Cc1ccc2c(c1)OCCC2Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5179131 IC50 4.0 nM
CC(C)(O)C12CC(C1)N(c1cc(-n3ncc4ccc(-c5ccn[nH]5)cc43)ncn1)C2 CHEMBL5279615 IC50 4.0 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCOC5(CC5)C4)ncn3)c2c1 CHEMBL3977482 IC50 4.04 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(C#N)CC3)cc2OC)ncc1Br CHEMBL3641798 Ki 4.1 nM
CNc1nc(Nc2cc(OC)c(C(=O)NC3COC3)cc2Cl)ncc1C(F)(F)F CHEMBL3641848 Ki 4.1 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCNCC3)cc2Cl)ncc1C(F)(F)F CHEMBL3641850 Ki 4.1 nM
COCCNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1Br CHEMBL3641890 Ki 4.1 nM
CNc1nc(Nc2ccc(C(=O)N3CCCC3)cc2OC)ncc1C(F)(F)F CHEMBL3643961 Ki 4.1 nM
CCC(C#N)Cn1cc(Nc2ncc(C(F)(F)F)c(NC)n2)c(C)n1 CHEMBL3974507 Ki 4.1 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C5CC5)CC4)ncn3)c2c1 CHEMBL3896174 IC50 4.1 nM
FC(F)(F)c1cc(-c2n[nH]c3ccnc(NC4CCOCC4)c23)ncn1 CHEMBL4527314 Ki 4.1 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CCCO5)CC4)ncn3)c2c1 CHEMBL3950044 IC50 4.13 nM
Cc1cnc(Cc2nc3cnc4ccc(C(F)(F)F)cc4c3n2[C@@H]2CCO[C@H](C)C2)cn1 CHEMBL4543181 IC50 4.13 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C(=O)C5CC5)CC4)ncn3)c2c1 CHEMBL3911415 IC50 4.15 nM
CCN1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1=O CHEMBL3914353 IC50 4.16 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(S(=O)(=O)C5CC5)CC4)ncn3)n[nH]c2cc1F CHEMBL3967326 IC50 4.17 nM
Cc1[nH]nc(-c2ccnc(N3CCOCC3)c2)c1-c1ccc(N2CCC3(CCOCC3)C2)cc1 CHEMBL5404275 IC50 4.19 nM
CNc1nc(Nc2ccc(C(=O)N3CCOC(CC(C)C)C3)cc2OC)ncc1Cl CHEMBL3641784 Ki 4.2 nM
CNc1nc(Nc2ccc(C(=O)NCC3CC3)cc2OC)ncc1C#N CHEMBL3641865 Ki 4.2 nM
CCOc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(C(F)(F)F)c(NC)n1 CHEMBL3641880 Ki 4.2 nM
CNc1nc(Nc2cc(OC)c(C(=O)NC3(C#N)CC3)cc2Cl)ncc1C(F)(F)F CHEMBL3643952 Ki 4.2 nM
c1cc(-c2n[nH]c3ccnc(OC4CCOCC4)c23)cc(N2CCOCC2)n1 CHEMBL4460272 Ki 4.2 nM
CCC(=O)N1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1 CHEMBL3985545 IC50 4.26 nM
CCOc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(NC)n1 CHEMBL3641786 Ki 4.3 nM
CNc1nc(Nc2cn(C(C)(C)c3ncccn3)nc2C)ncc1C(F)(F)F CHEMBL3923603 Ki 4.3 nM
FC1CN(C2COC2)CCC1c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl CHEMBL5082563 fIC50 4.3 nM
Cc1[nH]nc(-c2ccncc2)c1-c1cc(F)c(-c2cccc(S(N)(=O)=O)c2)c(F)c1 CHEMBL5172291 IC50 4.3 nM
CCC(=O)N1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1 CHEMBL3947673 IC50 4.32 nM
CC(C)Oc1cc2c(-c3cc(N4CCN(C)CC4)ncn3)n[nH]c2cc1F CHEMBL3960371 IC50 4.35 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC5(CCC(=O)N5)CC4)ncn3)c2c1 CHEMBL3905784 IC50 4.36 nM
CCCN1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1=O CHEMBL3952893 IC50 4.39 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3CO)cc2OC)ncc1Cl CHEMBL3641783 Ki 4.4 nM
CNc1nc(Nc2ccc(C(=O)NC(C)C)cc2OC)ncc1C#N CHEMBL3641869 Ki 4.4 nM
CC(C)Oc1ccc2[nH]nc(-c3ccnc(N4CCC(n5cnnc5)CC4)c3)c2c1 CHEMBL4075195 IC50 4.4 nM
N#CC1(c2ccc3cnn(-c4cc(N5CC[C@@H](O)[C@@H](F)C5)ncn4)c3c2)CC2(CC2)C1 CHEMBL4579292 IC50 4.4 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC(C(=O)O)CC4)ncn3)c2c1 CHEMBL3922307 IC50 4.45 nM
CNc1nc(Nc2ccc(C(=O)N3CC4CC3CO4)cc2OC)ncc1Cl CHEMBL3641790 Ki 4.5 nM
CNc1nc(Nc2cc(OC)c(C(=O)NC3CCN(C)CC3)cc2Cl)ncc1Cl CHEMBL3641834 Ki 4.5 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(C#N)C3)cc2Cl)ncc1Cl CHEMBL3641845 Ki 4.5 nM
CCNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC(C)C)ncc1C(F)(F)F CHEMBL3641904 Ki 4.5 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCN(S(C)(=O)=O)CC4)ncn3)c2c1 CHEMBL3915899 IC50 4.5 nM
C[C@@]1(N2CCC(c3cc4cc(NC(=O)C5CC5)ncc4cc3Cl)CC2)COC[C@@H]1O CHEMBL5407732 fIC50 4.5 nM
CNc1nc(Nc2ccc(C(=O)NC(C)(C)C)cc2OC)ncc1C#N CHEMBL3641873 Ki 4.6 nM
CNC(=O)c1cc(Cl)c(Nc2ncc(C(F)(F)F)c(NC)n2)cc1OC CHEMBL3643953 Ki 4.6 nM
CN(C)[C@H]1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)C1 CHEMBL3946083 IC50 4.6 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCC(F)(F)CC5)ncn4)c3c2)cn1 CHEMBL3911917 IC50 4.6 nM
Cc1[nH]nc(-c2ccncc2)c1-c1cc(F)c(N2CCC3(CCS(=O)(=O)CC3)C2)c(F)c1 CHEMBL5396660 IC50 4.6 nM
CNc1nc(Nc2ccc(C(=O)N3CCCC3)cc2OC)ncc1Cl CHEMBL3641780 Ki 4.7 nM
CNC(=O)c1cc(OC)c(Nc2ncc(C(F)(F)F)c(NC)n2)cc1F CHEMBL3641853 Ki 4.7 nM
CC(C)Oc1cc2c(-c3cc(N4C[C@H](F)[C@@H](F)C4)ncn3)n[nH]c2cc1F CHEMBL3930240 IC50 4.78 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2F)ncc1C(F)(F)F CHEMBL2178131 Ki 4.8 nM
CNc1nc(Nc2cn(C(C)(C)CO)nc2C)ncc1C(F)(F)F CHEMBL3977916 Ki 4.8 nM
CNc1nc(Nc2cn(C3(C)COC3)nc2C)ncc1C(F)(F)F CHEMBL3906241 Ki 4.8 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@@H](OC)C4)ncn3)c2c1 CHEMBL3971726 IC50 4.8 nM
Clc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1C1CCN(C2COC2)CC1 CHEMBL5090739 fIC50 4.8 nM
Cn1cc(-c2cccc(C(=O)Nc3cc(N4CC(O)C4)ncc3C(F)(F)F)n2)cn1 CHEMBL5190679 IC50 4.8 nM
CNc1nc(Nc2ccc(C(=O)N3CC(C)OC(C)C3)cc2OC)ncc1C(F)(F)F CHEMBL3643964 Ki 4.9 nM
COCCN1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1 CHEMBL3914163 IC50 4.9 nM
C[C@H]1c2c(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)cnn2CCN1C CHEMBL3902780 Ki 4.9 nM
CN1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)CC1=O CHEMBL3945097 IC50 4.91 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Br)c(OC)n1 CHEMBL2178123 Ki 5.0 nM
CNc1nc(Nc2cn(CCC#N)nc2C)ncc1C(F)(F)F CHEMBL2326722 Ki(app) 5.0 nM
CC(C)Nc1c(C#N)cnc2cc(-c3cnn(C)c3)ccc12 CHEMBL2347824 IC50 5.0 nM
COc1cc(-c2cnc3[nH]cc(-c4ccc(N)nc4)c3c2)cc(OC)c1OC CHEMBL2436982 IC50 5.0 nM
N#CCC1CN(c2ncnc3[nH]cc(-c4cccc(C#N)c4)c23)CCO1 CHEMBL3393446 IC50 5.0 nM
CN(C)c1ncnc2[nH]cc(-c3cccc(C#N)c3)c12 CHEMBL3393346 IC50 5.0 nM
c1cc2[nH]nc(-c3cnn(C4CCOC4)c3)c2c(OC2CCOCC2)n1 CHEMBL3651758 Ki 5.0 nM
Cc1cc(-c2n[nH]c3ccnc(OC4CCOCC4)c23)cc(C)n1 CHEMBL3651759 Ki 5.0 nM
Clc1ccccc1C#Cc1[nH]nc2ccnc(OC3CCOCC3)c12 CHEMBL3651781 Ki 5.0 nM
c1cc2[nH]cc(-c3cnn([C@@H]4CCOC4)c3)c2c(OC2CCOCC2)n1 CHEMBL3651788 Ki 5.0 nM
CNc1nc(Nc2cc(OC)c(-c3ccnn3C)cc2Cl)ncc1C(F)(F)F CHEMBL3681032 Ki 5.0 nM
CNc1nc(Nc2cc(F)c(-n3nc(C)cc3COC)cc2OC)ncc1C(F)(F)F CHEMBL3681051 Ki 5.0 nM
CNc1nc(Nc2cc3nc(C)oc3cc2Cl)ncc1C(F)(F)F CHEMBL3694799 Ki 5.0 nM
CNc1nc(Nc2cc3c(cc2OC)CN(C)C3=O)ncc1C(F)(F)F CHEMBL3694800 Ki 5.0 nM
CNc1nc(Nc2cc3c(cc2OC)C(=O)N(C)C3)ncc1C(F)(F)F CHEMBL3694813 Ki 5.0 nM
COc1cc(C(=O)N2CC(N3CCOCC3)C2)ccc1Nc1ncc(Br)c(OC)n1 CHEMBL3641811 Ki 5.0 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(OC)C3)cc2Cl)ncc1C(F)(F)F CHEMBL3641900 Ki 5.0 nM
CCNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2Cl)ncc1Cl CHEMBL3643944 Ki 5.0 nM
CNc1nc(Nc2cnn(CC3(O)CC3)c2Cl)ncc1C(F)(F)F CHEMBL3916336 Ki 5.0 nM
COc1cc(C(=O)N2CCN(C3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C CHEMBL4647792 IC50 5.0 nM
N#Cc1c(F)cccc1Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5200822 IC50 5.0 nM
N#Cc1ccc2c(c1)CCC2Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5179942 IC50 5.0 nM
CC(C)Oc1cc2c(-c3cc(N4CCO[C@@H](C)C4)ncn3)n[nH]c2cc1F CHEMBL3933109 IC50 5.01 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCO[C@H](C)C4)ncn3)c2c1 CHEMBL4111923 IC50 5.09 nM
CNc1nc(Nc2ccc(C(N)=O)cc2OC)ncc1Cl CHEMBL3641787 Ki 5.1 nM
CNc1nc(Nc2ccc(C(=O)N3CC[C@@H](O)C3)cc2OC)ncc1Br CHEMBL3641802 Ki 5.1 nM
CNc1nc(Nc2ccc(C(=O)N(C)CCOC)cc2OC)ncc1C(F)(F)F CHEMBL3643982 Ki 5.1 nM
CC(C)NC(=O)CN1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1 CHEMBL3955983 IC50 5.1 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CC6CCC(C5)O6)ncn4)c3c2)cn1 CHEMBL3959075 IC50 5.18 nM
CNc1nc(Nc2ccc(C(=O)N3CCC3)cc2OC)ncc1Cl CHEMBL3641775 Ki 5.2 nM
CNc1nc(Nc2cc(OC)c(C(=O)NC3CC3)cc2Cl)ncc1C(F)(F)F CHEMBL3641833 Ki 5.2 nM
CNc1nc(Nc2ccc(CC(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL3641887 Ki 5.2 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OCC2CCC2)ncc1C(F)(F)F CHEMBL3643972 Ki 5.2 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@H](OC)C4)ncn3)c2c1 CHEMBL3975433 IC50 5.27 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C(C)C)C(=O)C4)ncn3)c2c1 CHEMBL3975802 IC50 5.28 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCOC(C)(C)C4)ncn3)c2c1 CHEMBL3951097 IC50 5.3 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CC(O)C3)cc2Cl)ncc1Cl CHEMBL3641843 Ki 5.4 nM
CCN(C(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1)C(C)C CHEMBL3641874 Ki 5.4 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C)CC4)ncn3)c2c1 CHEMBL3919965 IC50 5.4 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(c5cnn(C)c5)CC4)ncn3)c2c1 CHEMBL3926553 IC50 5.4 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC(C(C)(C)O)CC4)ncn3)c2c1 CHEMBL3951760 IC50 5.4 nM
CC(C)Oc1cc2c(-c3cc(N4[C@H](C)COC[C@@H]4C)ncn3)n[nH]c2cc1F CHEMBL3946153 IC50 5.4 nM
CCC1(CC)CN(C(=O)c2ccc(Nc3ncc(Cl)c(NC)n3)c(OC)c2)CCO1 CHEMBL3641782 Ki 5.5 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(CCF)CC4)ncn3)c2c1 CHEMBL3967186 IC50 5.5 nM
CNc1nc(Nc2cc(F)c(N3CCCCC3=O)cc2OC)ncc1C(F)(F)F CHEMBL3985884 Ki 5.5 nM
c1cncc(-c2ccc3[nH]nc(-c4cc(N5CCOCC5)ncn4)c3c2)c1 CHEMBL3932912 IC50 5.5 nM
Cc1c(Nc2nc(N)c3c(C#N)c(N4CCC[C@H]4C)n(C)c3n2)cnn1[C@H]1CCOC1 CHEMBL5092087 Kd 5.5 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(S(=O)(=O)C5CC5)CC4)ncn3)c2c1 CHEMBL3932899 IC50 5.51 nM
CC(C)Oc1cc2c(-c3cc(N4CCOCC4C)ncn3)n[nH]c2cc1F CHEMBL3901271 IC50 5.54 nM
C[C@@H]1C[C@H](n2c(Cc3cn(C)nn3)nc3cnc4ccc(C(F)(F)F)cc4c32)CCO1 CHEMBL4466740 IC50 5.55 nM
COCCN1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1=O CHEMBL3942829 IC50 5.59 nM
COc1cc(CC(=O)N2CCOCC2)ccc1Nc1ncc(Br)c(OC)n1 CHEMBL3639407 Ki 5.6 nM
CCN1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1=O CHEMBL3946512 IC50 5.6 nM
COCC(=O)N1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1 CHEMBL3931530 IC50 5.6 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC(OC)C4)ncn3)c2c1 CHEMBL3933137 IC50 5.6 nM
FC1(F)CCN(c2cc(-c3n[nH]c4ccc(-c5cn[nH]c5)cc34)ncn2)CC1 CHEMBL3923796 IC50 5.69 nM
COCCOc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1Br CHEMBL3641821 Ki 5.7 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCCOCC3)cc2Cl)ncc1Cl CHEMBL3641841 Ki 5.7 nM
CNc1nc(Nc2cc(F)c(C(=O)N(C)CCOC)cc2OC)ncc1C(F)(F)F CHEMBL3643984 Ki 5.9 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC(O)CC4)ncn3)c2c1 CHEMBL3900243 IC50 5.9 nM
COc1cc(NS(C)(=O)=O)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C CHEMBL4636475 IC50 5.9 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4C[C@@H]5C[C@H]4CO5)ncn3)c2c1 CHEMBL3891819 IC50 5.94 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCOCC4)ncn3)c2c1 CHEMBL3928102 IC50 5.95 nM
CNc1nc(Nc2ccccc2OC)ncc1Cl CHEMBL2171738 Ki 6.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL2171748 Ki 6.0 nM
CNc1nc(Nc2cnn(CCC#N)c2C)ncc1C(F)(F)F CHEMBL2326723 Ki(app) 6.0 nM
CNc1nc(Nc2cn(CCOC)nc2C)ncc1C(F)(F)F CHEMBL2326720 Ki(app) 6.0 nM
CNc1nc(Nc2cn(C(C)C)nc2C)ncc1C(F)(F)F CHEMBL2326718 Ki(app) 6.0 nM
CCn1cc(Nc2ncc(C(F)(F)F)c(NC)n2)c(C)n1 CHEMBL2326716 Ki(app) 6.0 nM
CNS(=O)(=O)c1ccc(-c2ccc3c(NC(C)C)c(C#N)cnc3c2)cc1 CHEMBL2347825 IC50 6.0 nM
Brc1cccc(Sc2ccc3nnc(-c4cncs4)n3n2)c1 CHEMBL2348962 IC50 6.0 nM
CNc1nc(Nc2cnn3c2C(C)O[C@@H](C)C3)ncc1C(F)(F)F CHEMBL3122107 Ki 6.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCCCC4)c23)c1 CHEMBL3393343 IC50 6.0 nM
CN1CCN(c2ccc(OCc3ccccc3)c(C(=O)Nc3cccnc3)c2)CC1 CHEMBL3604124 IC50 6.0 nM
CN1CCN(c2cc(-c3n[nH]c4ccnc(OC5CCOCC5)c34)ccn2)CC1 CHEMBL3651733 Ki 6.0 nM
FC(F)(F)Cn1cc(-c2n[nH]c3ccnc(OC4CCOCC4)c23)cn1 CHEMBL3651757 Ki 6.0 nM
CC1CCCN(c2cc(-c3n[nH]c4ccnc(OC5CCOCC5)c34)ccn2)C1 CHEMBL3651767 Ki 6.0 nM
CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)N4CCCC4)n(C(C)C)c3)c12 CHEMBL3655552 Ki 6.0 nM
CNc1nc(Nc2cc3c(cc2OC)C(=O)N(C2COC2)C3)ncc1C(F)(F)F CHEMBL3694816 Ki 6.0 nM
CNc1nc(Nc2cc3c(cc2Cl)c(C(=O)N(C)C)cn3C)ncc1C(F)(F)F CHEMBL3694818 Ki 6.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2Cl)ncc1Cl CHEMBL3641819 Ki 6.0 nM
CNc1nc(Nc2ccc(C(=O)N3CC[C@H](F)C3)cc2OC)ncc1C#N CHEMBL3641866 Ki 6.0 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCOCC3)cc2Cl)ncc1Cl CHEMBL3643979 Ki 6.0 nM
COc1cc(C(=O)N2CCCC2)ccc1Nc1ncc(Cl)c(OC)n1 CHEMBL3643980 Ki 6.0 nM
CN(C)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12 CHEMBL3891060 IC50 6.0 nM
Brc1cncc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 CHEMBL3929926 IC50 6.0 nM
CCN1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1 CHEMBL3923675 IC50 6.0 nM
CO[C@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ncn2)C[C@@H]1O CHEMBL3902903 IC50 6.0 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@H](CO)C4)ncn3)c2c1 CHEMBL3890121 IC50 6.0 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCOC[C@@H]4C)ncn3)c2c1 CHEMBL3953703 IC50 6.0 nM
COc1cccc(-c2ccnc3[nH]cc(C#N)c23)c1 CHEMBL3979676 Ki 6.0 nM
C[C@@H]1CCCN1c1c(C#N)c2c(N)nc(N)nc2n1C CHEMBL5089834 Ki 6.0 nM
C[C@@H]1CCCN1c1c(C#N)c2c(N)nc(Nc3ccn(C)n3)cc2n1C CHEMBL5073457 Ki 6.0 nM
N#Cc1ccc(Nc2ccc3[nH]nc(-c4ccncc4)c3c2)c(C#N)c1 CHEMBL5169393 IC50 6.0 nM
Cc1ccc(Nc2ccc3[nH]nc(-c4ccncc4)c3c2)c(C#N)c1 CHEMBL5174552 IC50 6.0 nM
CC(C)(O)[C@@H]1CCN(c2cc(-n3ncc4ccc(-c5ccn[nH]5)cc43)ncn2)C1 CHEMBL5282583 IC50 6.0 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(C(N)=O)c3c2)Cn2nnnc2N1C CHEMBL5266676 IC50 6.0 nM
Cc1ncsc1-c1ccc([C@@H](C)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)CCOCCOCCOCCC(=O)N2CCN(c3cc(-c4n[nH]c5ccc(OC6(C)CC6)cc45)ncn3)CC2)C(C)(C)C)cc1 CHEMBL5395279 IC50 6.0 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4C=CSCC4)ncn3)c2c1 CHEMBL3971462 IC50 6.08 nM
CNc1nc(Nc2ccc(C(=O)N(C)C)cc2OC)ncc1Cl CHEMBL3641769 Ki 6.1 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(O)CC3)cc2C)ncc1Cl CHEMBL3641892 Ki 6.1 nM
CC(C)Oc1cc2c(-c3cc(N4CCC(F)(F)C4)ncn3)n[nH]c2cc1F CHEMBL3975329 IC50 6.1 nM
CC(C)Oc1cc2c(-c3cc(N4CC[S+]([O-])CC4)ncn3)n[nH]c2cc1F CHEMBL3892022 IC50 6.1 nM
CC(C)Oc1cc2c(-c3cc(N4CCC(n5cccn5)C4)ncn3)n[nH]c2cc1F CHEMBL3973695 IC50 6.1 nM
CCOC(=O)N1CCN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)CC1 CHEMBL3917046 IC50 6.1 nM
CN1C(=O)c2ccccc2N(C)c2nc(Nc3cccc(S(N)(=O)=O)c3)ncc21 CHEMBL3904942 IC50 6.1 nM
FC1CN(C2COC2)CCC1c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl CHEMBL5070231 fIC50 6.1 nM
CCc1cc(-c2c[nH]nc2-c2ccncc2)ccc1-c1cccc(S(N)(=O)=O)c1 CHEMBL5187306 IC50 6.1 nM
Cc1cc(-c2c(-c3ccncc3)n[nH]c2C)ccc1-c1cccc(S(N)(=O)=O)c1 CHEMBL5198878 IC50 6.15 nM
CNc1nc(Nc2ccc(C(=O)N3CC(C)CC(C)C3)cc2OC)ncc1Cl CHEMBL3641773 Ki 6.2 nM
CCNc1nc(Nc2cnn(C3CCOCC3)c2Cl)ncc1C#N CHEMBL3974439 Ki 6.2 nM
CC(C)Oc1cc2c(-c3cc(N4CCOC(C)(C)C4)ncn3)n[nH]c2cc1F CHEMBL3911871 IC50 6.2 nM
Cc1cc(-c2n[nH]cc2-c2ccc(-c3cccc(S(N)(=O)=O)c3)cc2)ccn1 CHEMBL5185437 IC50 6.2 nM
N#Cc1ccc(Nc2ccc3[nH]nc(-c4ccncc4)c3c2)c([N+](=O)[O-])c1 CHEMBL5182980 IC50 6.2 nM
c1cnn2c(-c3c[nH]c4ncnc(N5CCOCC5)c34)cnc2c1 CHEMBL3981043 IC50 6.26 nM
CNc1nc(Nc2cc(OC)c(C(=O)N(C)CC(C)(C)O)cc2Cl)ncc1C(F)(F)F CHEMBL3641854 Ki 6.3 nM
CNc1nc(Nc2ccc(C(=O)N3CC4(COC4)C3)cc2OC2CCCC2)ncc1Cl CHEMBL3641860 Ki 6.3 nM
CNc1nc(Nc2ccc(C(=O)N3CC4(COC4)C3)cc2OC)ncc1Cl CHEMBL3641861 Ki 6.3 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC(F)(CO)CC4)ncn3)c2c1 CHEMBL3950409 IC50 6.3 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCN6C(=O)OCC6C5)ncn4)c3c2)cn1 CHEMBL3967017 IC50 6.3 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 6.31 nM
CCOc1nc(Nc2ccc(C(=O)N3CCC4(CC3)CN(C)C4)cc2OC)nc2[nH]ccc12 CHEMBL4746922 pIC50 6.31 nM
CCOc1nc(Nc2ccc(C(=O)N3CCC(F)CC3)cc2OC)nc2[nH]ccc12 CHEMBL4751816 pIC50 6.31 nM
Cn1cc(-c2c[nH]c3ncnc(N4CCOCC4)c23)cc1C#N CHEMBL3906208 IC50 6.37 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCOC(C)(C)C4)ncn3)c2c1 CHEMBL3962713 IC50 6.37 nM
Cc1cc(Cc2nc3cnc4ccc(C#N)cc4c3n2[C@@H]2CCN(C)C2)ncn1 CHEMBL4521173 IC50 6.39 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(C(F)(F)F)C3)cc2OC)ncc1Br CHEMBL3641797 Ki 6.4 nM
Cc1nc2c(o1)CCN(c1cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn1)C2 CHEMBL3934301 IC50 6.4 nM
c1cnnc(-c2ccc3[nH]nc(-c4ccnc(N5CCOCC5)c4)c3c2)c1 CHEMBL4071415 IC50 6.4 nM
CNc1nc(Nc2cnn(S(=O)(=O)CCOC)c2C)ncc1C(F)(F)F CHEMBL3930267 Ki 6.46 nM
CNc1nc(Nc2ccc(C(=O)NC3CC(F)(F)C3)cc2OC)ncc1C#N CHEMBL3641864 Ki 6.5 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OCC2CC2)ncc1C(F)(F)F CHEMBL3643971 Ki 6.5 nM
CCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1C#N CHEMBL3643992 Ki 6.5 nM
CCNc1nc(Nc2cn(C(C)(C)c3nnc(CC)o3)nc2C)ncc1C(F)(F)F CHEMBL3972247 Ki 6.5 nM
CNC(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1 CHEMBL3641867 Ki 6.6 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4C[C@H](O)[C@@H](N(C)C)C4)ncn3)c2c1 CHEMBL3962458 IC50 6.6 nM
CC(C)Oc1ccc2[nH]nc(-c3ccnc(N4C[C@@H](F)[C@H](F)C4)c3)c2c1 CHEMBL4103352 IC50 6.6 nM
COc1ccncc1-c1ccc2[nH]nc(-c3cc(N4CCC(F)(F)CC4)ncn3)c2c1 CHEMBL3933792 IC50 6.66 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@H](N)C4)ncn3)c2c1 CHEMBL3905416 IC50 6.68 nM
CNc1nc(Nc2cc(OC)c(C(=O)N(C)C)cc2Cl)ncc1C(F)(F)F CHEMBL3641837 Ki 6.8 nM
CCN(CC)C(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1 CHEMBL3641868 Ki 6.8 nM
CNc1nc(Nc2ccc(C(=O)N(C)C(C)C)cc2OC)ncc1C#N CHEMBL3641877 Ki 6.8 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCOC(CO)C3)cc2Cl)ncc1Cl CHEMBL3641839 Ki 6.9 nM
COCCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1Br CHEMBL3641857 Ki 6.9 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCCC(C(C)(C)O)C4)ncn3)c2c1 CHEMBL3901579 IC50 6.9 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC(CF)C4)ncn3)c2c1 CHEMBL3918499 IC50 6.9 nM
Cc1c(Nc2ncc3ccc(C4(C#N)CC45CC5)cc3n2)cnn1C1CCOCC1 CHEMBL5085777 fIC50 6.9 nM
Cc1cc(-c2n[nH]c(C)c2-c2ccc(-c3cccc(S(N)(=O)=O)c3)cc2)ccn1 CHEMBL5204372 IC50 6.9 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2C)ncc1Cl CHEMBL2171741 Ki 7.0 nM
CNc1nc(Nc2ccccc2OC(F)F)ncc1Cl CHEMBL2171740 Ki 7.0 nM
CNc1nc(Nc2cc(C)c(C(=O)N3CCOCC3)cc2Cl)ncc1C(F)(F)F CHEMBL2178129 Ki 7.0 nM
CC(=O)N1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(C#N)cc43)cc2C1 CHEMBL2403377 IC50 7.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)c1cnoc1C)C3)C(=O)N2 CHEMBL2403368 IC50 7.0 nM
C[C@H]1CN(c2ncnc3[nH]cc(-c4cccc(C#N)c4)c23)CCO1 CHEMBL3393444 IC50 7.0 nM
CC(C)c1nc(-c2n[nH]c3ccnc(NC4CCOCC4)c23)n[nH]1 CHEMBL3651804 Ki 7.0 nM
Cn1cccc(Nc2n[nH]c3ccnc(OC4CCOCC4)c23)c1=O CHEMBL3651809 Ki 7.0 nM
CC(C)n1cc(-c2n[nH]c3ccnc(OC4CCOC4)c23)cn1 CHEMBL3655556 Ki 7.0 nM
CNc1nc(Nc2ccc(-c3nnnn3C)cc2Cl)ncc1C(F)(F)F CHEMBL2178136 Ki 7.0 nM
CNc1nc(Nc2ccc(-c3nnnn3C)cc2OC)ncc1Cl CHEMBL3676114 Ki 7.0 nM
CNc1nc(Nc2ccc(-c3nccn3C)cc2OC)ncc1Cl CHEMBL3676117 Ki 7.0 nM
CCNc1nc(Nc2cc(F)c(-c3nnc(C)o3)cc2OC)ncc1C(F)(F)F CHEMBL3681033 Ki 7.0 nM
CNc1nc(Nc2ccc3c(c2OC)CN(C2CC2)C3=O)ncc1C(F)(F)F CHEMBL3694803 Ki 7.0 nM
CNc1nc(Nc2cc3c(cc2OC)C(=O)N(C)CC3)ncc1C(F)(F)F CHEMBL3694807 Ki 7.0 nM
CNc1nc(Nc2ccc(C(=O)O)cc2OC)ncc1Cl CHEMBL3978211 Ki 7.0 nM
COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12 CHEMBL3965800 IC50 7.0 nM
CC(C)Oc1cc2c(-c3cc(N4CC[C@H](N(C)C)C4)ncn3)n[nH]c2cc1F CHEMBL3986785 IC50 7.0 nM
CN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 CHEMBL1673047 IC50 7.0 nM
CCn1cc(-c2cccc(C(=O)Nc3cc(N4CC[C@@H](C(C)(C)O)C4)cnc3C(F)(F)F)n2)cn1 CHEMBL5187647 IC50 7.0 nM
COc1ccc(Nc2ccc3[nH]nc(-c4ccncc4)c3c2)c(C#N)c1 CHEMBL5184816 IC50 7.0 nM
CC1(C)CC(=O)C=C(c2ccc3[nH]nc(-c4cc(N5CCC(F)(F)CC5)ncn4)c3c2)C1 CHEMBL3936325 IC50 7.08 nM
CC(C)Oc1cc2c(-c3cc(N4CCn5ncnc5C4)ncn3)n[nH]c2cc1F CHEMBL3955624 IC50 7.1 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC(C#N)CC4)ncn3)c2c1 CHEMBL3916009 IC50 7.2 nM
Cc1c(Nc2ncc(C#N)c(NC3CC3)n2)cnn1C1CCOCC1 CHEMBL3923482 Ki 7.3 nM
CC(C)Oc1cc2c(-c3cc(N4CC[C@@H](N)C4)ncn3)n[nH]c2cc1F CHEMBL4108580 IC50 7.3 nM
CS(=O)(=O)N1CCN(c2cc(-c3n[nH]c4ccc(-c5cccnc5)cc34)ncn2)CC1 CHEMBL3921038 IC50 7.3 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCCC3)cc2Cl)ncc1Cl CHEMBL3641835 Ki 7.4 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(CCO)CC4)ncn3)c2c1 CHEMBL3967517 IC50 7.4 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4[C@H](C)COC[C@@H]4C)ncn3)c2c1 CHEMBL3985716 IC50 7.4 nM
FC(F)Cn1ncc(Nc2ncc3cc(Cl)c(C4CCN(C5COC5)CC4F)cc3n2)c1Cl CHEMBL5082260 fIC50 7.4 nM
Cn1cc(-c2c[nH]c3ncnc(N4CCOCC4)c23)nc1C#N CHEMBL3901378 IC50 7.47 nM
CO[C@@H]1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)C1 CHEMBL4114530 IC50 7.47 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2Br)ncc1C(F)(F)F CHEMBL3643975 Ki 7.5 nM
CNc1nc(Nc2cnn3c2CCCC3)ncc1C(F)(F)F CHEMBL3978659 Ki 7.5 nM
CC(C)Oc1cc2c(-c3cc(N4C[C@H](N)C[C@@H]4C)ncn3)n[nH]c2cc1F CHEMBL3964794 IC50 7.6 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC(F)(F)C4)ncn3)c2c1 CHEMBL3954935 IC50 7.6 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cnc(N6CCCC6)s5)cc34)ncn2)C[C@H](C)O1 CHEMBL3977201 IC50 7.6 nM
Cc1[nH]nc(-c2ccncc2)c1-c1ccc(-c2cccc(S(N)(=O)=O)c2)c(F)c1 CHEMBL5170225 IC50 7.6 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C(C)C)CC4)ncn3)c2c1 CHEMBL3921447 IC50 7.68 nM
CO[C@H]1CN(c2cc(-c3n[nH]c4cc(F)c(OC(C)C)cc34)ncn2)C[C@@H]1O CHEMBL3924286 IC50 7.7 nM
Cc1noc(C2CN(c3ncnc4[nH]cc(-c5cccc(C#N)c5F)c34)CCO2)n1 CHEMBL3925893 IC50 7.71 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(F)(F)CC3)cc2Cl)ncc1Cl CHEMBL3641826 Ki 7.8 nM
CNc1nc(Nc2cc(OC)c(C(=O)N(C)CCO)cc2Cl)ncc1Cl CHEMBL3641840 Ki 7.8 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4C[C@@H](C)O[C@@H](C)C4)ncn3)c2c1 CHEMBL3948696 IC50 7.8 nM
CNc1nc(Nc2cc(OC)c(C(=O)NCC(C)(C)O)cc2Cl)ncc1C(F)(F)F CHEMBL3641849 Ki 7.9 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCC4)ncn3)c2c1 CHEMBL3936351 IC50 7.9 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCCC(C)(O)C5)ncn4)c3c2)cn1 CHEMBL3984695 IC50 7.9 nM
CC(C)Oc1cc2c(-c3cc(N4C[C@H](O)[C@@H](N(C)C)C4)ncn3)n[nH]c2cc1F CHEMBL3948602 IC50 7.9 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4C[C@H](F)[C@@H](F)C4)ncn3)c2c1 CHEMBL3924185 IC50 7.9 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 7.943 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 7.943 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 7.943 nM
O=C(Nc1cccnc1)c1cc(Br)ccc1OCc1ccccc1F CHEMBL4068065 pIC50 7.943 nM
O=C(Nc1cccnc1)c1cc(Br)ccc1OCc1ccc(F)cc1 CHEMBL4100294 pIC50 7.943 nM
Cn1cc(-c2ccc(OCc3ccccc3)c(C(=O)Nc3cccnc3)c2)cn1 CHEMBL4098650 pIC50 7.943 nM
O=C(Nc1cccnc1)c1cc(C(F)(F)F)ccc1OCc1ccc(F)cc1 CHEMBL4077195 pIC50 7.943 nM
N#Cc1cccc(NC(=O)c2cc(C(F)(F)F)ccc2OCc2ccc(F)cc2)c1 CHEMBL4560969 pIC50 7.943 nM
CCOc1nc(Nc2ccc(C(=O)N3CCN4CCC[C@@H]4C3)cc2OC)nc2[nH]ccc12 CHEMBL4752817 pIC50 7.943 nM
CCOc1nc(Nc2ccc(C(=O)N3CCOC[C@@H]3C)cc2OC)nc2[nH]ccc12 CHEMBL4780229 pIC50 7.943 nM
CCOc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)nc2[nH]ccc12 CHEMBL4749895 pIC50 7.943 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(S(C)(=O)=O)CC4)ncn3)c2c1 CHEMBL3977858 IC50 7.99 nM
CNc1nc(Nc2cn(C)nc2C)ncc1C(F)(F)F CHEMBL2326713 Ki(app) 8.0 nM
Clc1cccc(Sc2ccc3nnc(-c4cncs4)n3n2)c1 CHEMBL2348963 IC50 8.0 nM
COc1ccc2c(c1)/C(=C/c1[nH]c3c(c1Cl)CN(C(C)=O)CC3)C(=O)N2 CHEMBL2403371 IC50 8.0 nM
Cc1nc([C@@H]2CN(c3ncnc4[nH]cc(-c5cccc(C#N)c5)c34)CCO2)no1 CHEMBL3393449 IC50 8.0 nM
Clc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 CHEMBL3393355 IC50 8.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCCC4)c23)c1 CHEMBL3393344 IC50 8.0 nM
CC(C)n1cc(-c2n[nH]c3ccnc(OC4CCOCC4)c23)cc1C(=O)N1CCC1 CHEMBL3655553 Ki 8.0 nM
CNc1nc(Nc2cc(OC)c(-c3nnc(C)o3)cc2Cl)ncc1C(F)(F)F CHEMBL3676112 Ki 8.0 nM
CNc1nc(Nc2cc3c(cc2OC)N(C)C(=O)C(C)(C)O3)ncc1C(F)(F)F CHEMBL3694805 Ki 8.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCN(C4COC4)CC3)cc2OC)ncc1Br CHEMBL3641803 Ki 8.0 nM
CNc1nc(Nc2cc(F)c(C(=O)N3C[C@@H](C)O[C@@H](C)C3)cc2OC)ncc1C(F)(F)F CHEMBL3641903 Ki 8.0 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CC(C)OC(C)C3)cc2Cl)ncc1C(F)(F)F CHEMBL3643954 Ki 8.0 nM
CNc1nc(Nc2c(OC)cc(C#N)cc2C(F)(F)F)ncc1C(F)(F)F CHEMBL3947965 Ki 8.0 nM
CNc1nc(Nc2ccc(C#N)cc2OC)ncc1Cl CHEMBL3925122 Ki 8.0 nM
CNc1nc(Nc2ccc(S(C)(=O)=O)cc2Cl)ncc1C(F)(F)F CHEMBL3942044 Ki 8.0 nM
CNc1nc(Nc2ccc(S(C)(=O)=O)cc2Cl)ncc1Cl CHEMBL3938986 Ki 8.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCC[C@@H](O)C4)c23)c1 CHEMBL4112240 IC50 8.0 nM
Cc1nc(C2CN(c3ncnc4[nH]cc(-c5cccc(C#N)c5)c34)CCO2)no1 CHEMBL3935730 IC50 8.0 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCC(F)(F)CC4)ncn3)c2c1 CHEMBL3963980 IC50 8.0 nM
Cc1cc(-c2n[nH]c3ccc(N[C@H]4CCCc5cc(C#N)ccc54)cc23)ccn1 CHEMBL5177346 IC50 8.0 nM
N#Cc1ccccc1Oc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5182067 IC50 8.0 nM
Cc1cccc(Nc2ccc3[nH]nc(-c4ccncc4)c3c2)c1C#N CHEMBL5169734 IC50 8.0 nM
Cc1cccc(C#N)c1Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5209350 IC50 8.0 nM
N#Cc1ccc2c(c1)OCC[C@H]2Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5198808 IC50 8.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCC(F)(F)C3)cc2OC)ncc1C#N CHEMBL3641875 Ki 8.1 nM
Cc1[nH]nc(-c2ccncc2)c1-c1ccc(-c2cccc(S(N)(=O)=O)c2)c(F)c1F CHEMBL5207639 IC50 8.1 nM
CCCN1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)CC1 CHEMBL3969038 IC50 8.14 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(Cc5ccncc5)CC4)ncn3)c2c1 CHEMBL3977651 IC50 8.2 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C CHEMBL1673048 IC50 8.2 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C5CC5)CC4)ncn3)c2c1 CHEMBL3983779 IC50 8.28 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(N5CCOCC5)c4)c3c2)Cn2nnnc2N1C CHEMBL5277668 IC50 8.3 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCc5oc(C)nc5C4)ncn3)c2c1 CHEMBL3914466 IC50 8.4 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCn6ncnc6C5)ncn4)c3c2)cn1 CHEMBL3907548 IC50 8.5 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCC(O)C3)cc2Cl)ncc1Cl CHEMBL3641831 Ki 8.6 nM
CNc1nc(Nc2cc(C(C)(C)C#N)nn2C)ncc1C(F)(F)F CHEMBL3970272 Ki 8.6 nM
CCc1nnc2n1CCN(c1cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn1)C2 CHEMBL3972965 IC50 8.6 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCOC(C(F)(F)F)C4)ncn3)c2c1 CHEMBL3984978 IC50 8.6 nM
CNc1nc(Nc2cc(OC)c(CC(=O)N3CCOCC3)cc2OC)ncc1Cl CHEMBL3641885 Ki 8.7 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@@H](F)C4)ncn3)c2c1 CHEMBL4112183 IC50 8.7 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCN(C(=O)c5ccco5)CC4)ncn3)c2c1 CHEMBL3944894 IC50 8.7 nM
CCc1nc2cnc3ccc(Cl)cc3c2n1[C@@H]1CCO[C@H](CC#N)C1 CHEMBL4549553 IC50 8.7 nM
Cc1cc(-c2n[nH]cc2-c2ccc(-c3cccc(S(N)(=O)=O)c3)cc2)cc(C)n1 CHEMBL5190962 IC50 8.7 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@@H](N)C4)ncn3)c2c1 CHEMBL4115404 IC50 8.78 nM
CO[C@H]1CCN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)C1 CHEMBL3895221 IC50 8.79 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CCN5C(=O)OCC5C4)ncn3)c2c1 CHEMBL3933018 IC50 8.8 nM
O=C(Nc1cccnc1)c1cc(-c2ccnc(F)c2)ccc1OCc1ccccc1 CHEMBL2204495 IC50 8.9 nM
CNc1nc(Nc2cc(OC)c(C(=O)N3CCNCC3)cc2Cl)ncc1Cl CHEMBL3641829 Ki 8.9 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc(N5CCOC(C)(C)C5)ncn4)c3c2)cn1 CHEMBL3948540 IC50 8.9 nM
CNc1nc(Nc2cnc(C3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2178139 Ki 9.0 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(OC)n1 CHEMBL2178142 Ki 9.0 nM
CNc1nc(Nc2cnn(CC(C)(C)O)c2Cl)ncc1C(F)(F)F CHEMBL2326726 Ki(app) 9.0 nM
CNc1nc(Nc2cnn(CC(C)(C)O)c2C)ncc1C(F)(F)F CHEMBL2326725 Ki(app) 9.0 nM
CC(C)Nc1c(C(N)=O)nnc2cc(N3CCOCC3)ccc12 CHEMBL2333120 IC50 9.0 nM
CC(C)Nc1c(C(N)=O)nnc2cc(-c3cnn(C)c3)ccc12 CHEMBL2333118 IC50 9.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCN(C)CC1)C3)C(=O)N2 CHEMBL2403369 IC50 9.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)n1 CHEMBL3393359 IC50 9.0 nM
c1ccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)cc1 CHEMBL3393353 IC50 9.0 nM
c1cc(-c2n[nH]c3ccnc(OC4CCOCC4)c23)cc(N2CCC2)n1 CHEMBL3651769 Ki 9.0 nM
N#Cc1cccc(-c2cc(-c3n[nH]c4ccnc(OC5CCOCC5)c34)ccn2)c1 CHEMBL3655542 Ki 9.0 nM
CN(C)C(=O)c1ccc(-c2cc(-c3n[nH]c4ccnc(OC5CCOCC5)c34)ccn2)cc1 CHEMBL3655550 Ki 9.0 nM
CCN1Cc2c(ccc(Nc3ncc(C(F)(F)F)c(NC)n3)c2OC)C1=O CHEMBL3694810 Ki 9.0 nM
CNc1nc(Nc2ccc3c(c2OC)CN(C2COC2)C3=O)ncc1C(F)(F)F CHEMBL3694812 Ki 9.0 nM
CNc1nc(Nc2ccc(CC(=O)N3CCOCC3)cc2OC)ncc1Cl CHEMBL3641886 Ki 9.0 nM
CCOc1cc(C(=O)N2CCOCC2)c(F)cc1Nc1ncc(C(F)(F)F)c(NC)n1 CHEMBL3643981 Ki 9.0 nM
CNc1nc(Nc2ccc(CN3CCOCC3)cc2OCCF)ncc1Cl CHEMBL3978682 Ki 9.0 nM
CNc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL3972114 Ki 9.0 nM
C[C@H]1CCCN(c2ncnc3[nH]cc(-c4cccc(O)c4)c23)C1 CHEMBL3958751 IC50 9.0 nM
COc1cc(F)cc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 CHEMBL3956506 IC50 9.0 nM
Fc1ccc(Cl)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12 CHEMBL3973248 IC50 9.0 nM
Fc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 CHEMBL3923604 IC50 9.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCCC(O)C4)c23)c1F CHEMBL3920540 IC50 9.0 nM
C[C@H]1CCCN(c2ncnc3[nH]cc(-c4ccc(C(N)=O)cc4)c23)C1 CHEMBL3900759 IC50 9.0 nM
F[C@@H]1CNCC[C@H]1c1cc2nc(Nc3cnn([C@@H]4CC4(F)F)c3Cl)ncc2cc1Cl CHEMBL5076674 fIC50 9.0 nM
Cc1cnc(N2C[C@@H](C)O[C@@H](C)C2)cc1NC(=O)c1cccc(-c2cnn(C)c2)n1 CHEMBL5208974 IC50 9.0 nM
N#Cc1ccc2c(c1)CCC[C@H]2Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL5201629 IC50 9.0 nM
CC(C)N1CCN(c2cc(-c3n[nH]c4ccc(-c5ccoc5)cc34)ncn2)CC1 CHEMBL3967800 IC50 9.03 nM
CNc1nc(Nc2cc(F)c(C(=O)N(C)CC(C)(C)O)cc2OC)ncc1C(F)(F)F CHEMBL3641902 Ki 9.2 nM
CNc1nc(Nc2cc(OC)c(C(N)=O)cc2Cl)ncc1Cl CHEMBL3641823 Ki 9.3 nM
CCNc1nc(Nc2cc(OC)c(C(=O)NCCOC)cc2Cl)ncc1C(F)(F)F CHEMBL3641828 Ki 9.3 nM
Cc1noc(C2CN(c3cc(-c4n[nH]c5ccc(OC(C)C)cc45)ncn3)C2)n1 CHEMBL3906334 IC50 9.3 nM
COCCNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1Cl CHEMBL3641817 Ki 9.4 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC(C)C)ncc1C(F)(F)F CHEMBL3641879 Ki 9.4 nM
COc1cc(C(=O)N2CCOCC2)c(Cl)cc1Nc1ncc(Br)c(OC)n1 CHEMBL3643978 Ki 9.4 nM
CCNc1nc(Nc2cnn3c2[C@H](C)N(C)CC3)ncc1C(F)(F)F CHEMBL3893823 Ki 9.5 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CC[C@H](F)C4)ncn3)c2c1 CHEMBL3934534 IC50 9.5 nM
Cc1cc(-c2n[nH]c(C)c2-c2ccc(N3CCC4(CCOCC4)C3)cc2)cc(C)n1 CHEMBL5399757 IC50 9.59 nM
COCCNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OCC(F)(F)F)ncc1Cl CHEMBL3641818 Ki 9.6 nM
CCNC(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1 CHEMBL3641870 Ki 9.6 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(NCC(C)OC)n1 CHEMBL3641891 Ki 9.6 nM
CC(C)(C)Cn1cc(Nc2ncc3c(Cl)c(N4CCN(C5(C)COC5)CC4)ccc3n2)cn1 CHEMBL5414165 IC50 9.7 nM
N#Cc1ccc2ncc3nc(Cc4csnn4)n([C@@H]4CC[C@H](F)C4)c3c2c1 CHEMBL4562596 IC50 9.73 nM
CCNc1nc(Nc2cc(F)c(C(=O)N(C)C)cc2OC)ncc1C#N CHEMBL3641896 Ki 9.8 nM
CC(C)Oc1cc2c(-c3cc(N4CCc5oncc5C4)ncn3)n[nH]c2cc1F CHEMBL3966843 IC50 9.8 nM
CC(C)Oc1ccc2[nH]nc(-c3cc(N4CCOCC4C)ncn3)c2c1 CHEMBL3944850 IC50 9.82 nM
CO[C@H]1CN(c2cc(-c3n[nH]c4ccc(OC(C)C)cc34)ncn2)C[C@@H]1O CHEMBL3931365 IC50 9.9 nM
COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(N4CC5CCC(C4)O5)ncn3)c2c1 CHEMBL3935021 IC50 9.93 nM