Cc1cc2c(nn1)-c1cc(OCCCC(F)(F)F)ccc1C2=O CHEMBL348961 IC50 0.014 nM
C#CCN(C)[C@H](C)Cc1ccccc1 CHEMBL972 IC50 0.017 nM
C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O CHEMBL396778 IC50 0.023 nM
O=C(O)c1coc2ccccc2c1=O CHEMBL315361 IC50 0.048 nM
C#CCN[C@@H]1CCc2ccccc21 CHEMBL887 IC50 0.05 nM
C#CCN(C)[C@H](C)Cc1ccc(OCCCCCCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1 CHEMBL2333930 Ki 0.129 nM
Cc1ccc2oc(=O)c(-c3cccc(Br)c3)cc2c1 CHEMBL4129303 IC50 0.134 nM
Cn1ncc2cc(C(=O)Nc3ccc(Cl)c(Cl)c3)ccc21 CHEMBL3319256 Ki 0.17 nM
O=C(Nc1ccc(Cl)c(Cl)c1)c1ccc2[nH]ccc2c1 CHEMBL3319268 IC50 0.227 nM
O=C(Nc1ccc(Cl)c(Cl)c1)c1ccc2[nH]ncc2c1 CHEMBL3319244 Ki 0.26 nM
Clc1ccc(/N=C/c2ccc3[nH]ncc3c2)cc1Cl CHEMBL3319272 Ki 0.27 nM
O=C1Nc2ccc(CCCCc3ccccc3)cc2C1=O CHEMBL1642678 Ki 0.28 nM
Cn1ncc2cc(C(=O)Nc3ccc(F)c(Cl)c3)ccc21 CHEMBL4061639 Ki 0.29 nM
O=C(Nc1ccc(Cl)c(F)c1)c1ccc2[nH]ncc2c1 CHEMBL3319247 Ki 0.29 nM
O=C(Nc1ccc(F)c(Cl)c1)c1ccc2[nH]ncc2c1 CHEMBL3317469 Ki 0.3 nM
Cc1ccc(-c2cc3cc(C)ccc3oc2=O)cc1 CHEMBL1835228 IC50 0.308 nM
O=[N+]([O-])c1cccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)c1 CHEMBL1760721 Ki 0.31 nM
Cc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1C CHEMBL4209203 Ki 0.31 nM
O=C1CCc2cc(OCCCC(F)(F)F)ccc21 CHEMBL414637 IC50 0.318 nM
C#CCNC1CCc2c(SCCc3cccc(C)c3)cccc21 CHEMBL4861804 IC50 0.35 nM
O=C1CCc2ccc(OCc3ccccc3F)cc2O1 CHEMBL5407170 IC50 0.37 nM
O=c1cc(CCCl)c2ccc(OCc3cccc(Cl)c3)cc2o1 CHEMBL3359944 IC50 0.37 nM
O=C(Nc1cccc(Cl)c1)c1coc2ccccc2c1=O CHEMBL4206812 IC50 0.4 nM
O=C1OCc2ccc(OCc3ccc(C(F)(F)F)cc3)cc21 CHEMBL2391742 Ki 0.46 nM
Cn1ncc2cc(/C=N/c3ccc(Cl)c(Cl)c3)ccc21 CHEMBL3319273 Ki 0.46 nM
COCCn1ncc2cc(C(=O)Nc3ccc(Cl)c(Cl)c3)ccc21 CHEMBL4104691 Ki 0.48 nM
O=c1ccc2ccc(OCc3ccc(Br)cc3)cc2o1 CHEMBL4068321 IC50 0.5 nM
O=C(Nc1ccc2[nH]ccc2n1)c1ccc(Cl)c(Cl)c1 CHEMBL4450595 Ki 0.5 nM
Clc1cc(/N=C/c2ccc3[nH]ncc3c2)cnc1Cl CHEMBL4539722 Ki 0.57 nM
COCCn1ncc2cc(/C=N/c3ccc(Cl)c(Cl)c3)ccc21 CHEMBL4466571 Ki 0.57 nM
COC(=O)c1cc2ccc(OCc3cccc(F)c3)cc2oc1=O CHEMBL3121793 IC50 0.588 nM
C(/C=C/c1ccccc1)=C\c1ccccc1 CHEMBL198810 Ki 0.6 nM
Cn1cc2cc(C(=O)Nc3ccc(Cl)c(Cl)c3)ccc2n1 CHEMBL3319257 Ki 0.64 nM
COc1cccc(Cn2ccc3c(N4CCC(OC)CC4)nc4ccccc4c32)c1 CHEMBL5174789 IC50 0.7 nM
COc1ccc(-c2cc3cc(C)ccc3oc2=O)cc1Br CHEMBL1835231 IC50 0.74 nM
C#CCCCCOc1ccc2c(C)cc(=O)oc2c1 CHEMBL3121791 IC50 0.77 nM
COc1cccc(-c2cc3cc(C)ccc3oc2=O)c1 CHEMBL570731 IC50 0.8 nM
Cc1c(Cl)c(=O)oc2cc(OCc3ccc(Br)cc3)ccc12 CHEMBL4079843 IC50 0.8 nM
COC1CCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)CC1 CHEMBL5209131 IC50 0.8 nM
Fc1cc(/N=C/c2ccc3[nH]ncc3c2)ccc1Cl CHEMBL4567537 Ki 0.84 nM
CCCCCCOc1ccc2cc(C(=O)OC)c(=O)oc2c1 CHEMBL3121865 IC50 0.875 nM
Cc1c(C)c2ccc(OCc3nnc(C(C)C)s3)cc2oc1=O CHEMBL19004 IC50 0.9 nM
Cc1cc(=O)oc2cc(OCc3ccc(Br)cc3)ccc12 CHEMBL4097867 IC50 0.9 nM
Cc1c(C)c2ccc(OCc3cccc(F)c3)cc2oc1=O CHEMBL108697 pIC50 0.912 nM
O=c1oc2cc(OCc3ccccc3)ccc2c2c1CCC2 CHEMBL142799 pIC50 0.912 nM
Fc1ccc(/N=C/c2ccc3[nH]ncc3c2)cc1Cl CHEMBL4449231 Ki 0.93 nM
COc1cccc(-c2cc3cc(Cl)ccc3oc2=O)c1 CHEMBL5416702 IC50 1.0 nM
O=C(Nc1ccccc1Br)c1coc2ccccc2c1=O CHEMBL4591558 pIC50 1.023 nM
Cc1c(C)c2ccc(OCc3ccccc3)cc2oc1=O CHEMBL111309 pIC50 1.072 nM
Cc1c(C)c2ccc(OCc3cccc([N+](=O)[O-])c3)cc2oc1=O CHEMBL356977 pIC50 1.096 nM
Cc1c(C)c2ccc(OCc3ccc(F)c(F)c3)cc2oc1=O CHEMBL325761 IC50 1.1 nM
O=C1CCCc2ccc(OCc3ccc(Cl)cc3)cc21 CHEMBL5191498 IC50 1.1 nM
Cc1c(C)c2ccc(OCc3ccc([N+](=O)[O-])cc3)cc2oc1=O CHEMBL142582 pIC50 1.122 nM
O=c1oc2cc(OCc3ccccc3)ccc2c2ccccc12 CHEMBL145292 pIC50 1.122 nM
O=C(Nc1ccc(Br)cc1)c1coc2ccccc2c1=O CHEMBL4592562 pIC50 1.148 nM
O=[N+]([O-])c1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)cc1 CHEMBL1760713 Ki 1.15 nM
Cc1ccc2oc(=O)c(C(=O)Nc3cccc(Cl)c3)cc2c1 CHEMBL494798 Ki 1.17 nM
Clc1cccc(Cn2ccc3c(N4CCNCC4)nc4ccccc4c32)c1 CHEMBL5435388 pIC50 1.175 nM
C=C(Br)COc1ccc2c3c(c(=O)oc2c1C)CCC3 CHEMBL488074 IC50 1.18 nM
O=C1CCCc2ccc(OCc3ccccc3)cc21 CHEMBL5185721 IC50 1.2 nM
Cc1cccc(COc2ccc3c(C)c(C)c(=O)oc3c2)c1 CHEMBL109085 pIC50 1.202 nM
CC(=O)c1ccc(OCc2cccc(Cl)c2)cc1O CHEMBL3911291 IC50 1.3 nM
Cc1c(C#N)c(=O)oc2cc(OCc3ccc(Br)cc3)ccc12 CHEMBL4105601 IC50 1.3 nM
O=C(Nc1cccc(Br)c1)c1coc2ccccc2c1=O CHEMBL4204513 pIC50 1.318 nM
COc1ccc(-c2cc3cc(Br)cc(OC)c3oc2=O)cc1 CHEMBL1777845 IC50 1.35 nM
Cc1ccc(COc2ccc3c(C)c(C)c(=O)oc3c2)cc1 CHEMBL18966 pIC50 1.38 nM
Cc1c(C)c2ccc(NCc3ccccc3)cc2oc1=O CHEMBL348922 pIC50 1.38 nM
CS(=O)(=O)c1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1 CHEMBL470226 IC50 1.4 nM
COC(=O)c1cc2ccc(OCCc3ccc(Cl)cc3)cc2oc1=O CHEMBL3121795 IC50 1.41 nM
C#CCCCCOc1ccc2cc(C(=O)OC)c(=O)oc2c1 CHEMBL3121784 IC50 1.41 nM
Cc1c(C)c2ccc(OCc3cccc(C#N)c3)cc2oc1=O CHEMBL356714 pIC50 1.413 nM
O=C(Nc1ccc2[nH]ccc2n1)c1ccc(F)c(Cl)c1 CHEMBL4439889 Ki 1.45 nM
Cc1c(C)c2ccc(OCc3ccc(Cl)cc3)cc2oc1=O CHEMBL274030 pIC50 1.479 nM
C=C(Br)COc1ccc2c(oc(=O)c3ccccc32)c1C CHEMBL487235 IC50 1.49 nM
COc1ccc2c(=O)c(/C=C/c3ccc(Cl)cc3)coc2c1 CHEMBL4847545 Ki 1.5 nM
COc1ccc2oc(=O)c(-c3ccc(C)cc3)cc2c1 CHEMBL1835224 IC50 1.52 nM
Cn1ncc2cc(C(=O)Nc3ccc(F)c(F)c3)ccc21 CHEMBL4070309 IC50 1.52 nM
O=C(Nc1cccc(Cl)c1)c1csc2ccccc2c1=O CHEMBL4855359 IC50 1.52 nM
Cc1c(C)c2ccc(OCc3ccc(F)cc3)cc2oc1=O CHEMBL276076 pIC50 1.549 nM
Cc1cc(=O)oc2cc(OCc3ccccc3)ccc12 CHEMBL108660 pIC50 1.585 nM
O=C(Nc1ccc(F)c(F)c1)c1ccc2[nH]ncc2c1 CHEMBL3319248 IC50 1.59 nM
Cc1c(C)c2ccc(OCc3c(F)c(F)c(F)c(F)c3F)cc2oc1=O CHEMBL357614 pIC50 1.622 nM
O=C(COc1cccc(Cl)c1)Nc1nc2ccccc2c(=O)s1 CHEMBL2382430 IC50 1.63 nM
COc1cccc(COc2ccc3c(C)c(C)c(=O)oc3c2)c1 CHEMBL111310 pIC50 1.66 nM
O=c1ccc2ccc(OCc3ccccc3)cc2o1 CHEMBL145781 pIC50 1.698 nM
COc1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)cc1 CHEMBL1760722 Ki 1.7 nM
C/C(=N/Nc1nc(-c2ccc(F)cc2)cs1)c1cccnc1 CHEMBL2151667 IC50 1.7 nM
O=C(Nc1cccc(O)c1)c1coc2ccccc2c1=O CHEMBL4573588 IC50 1.73 nM
O=c1oc2cc(OCc3ccccc3)ccc2c2c1CCCC2 CHEMBL146222 pIC50 1.778 nM
Clc1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)cc1 CHEMBL1760715 Ki 1.8 nM
O=C1OCc2ccc(OCc3ccc(I)cc3)cc21 CHEMBL2391869 IC50 1.8 nM
OC1CCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)CC1 CHEMBL5178803 IC50 1.8 nM
Cc1ccc(C2=NO[C@@H](c3ccc(Cl)c(Cl)c3)C2)cc1 CHEMBL5282218 IC50 1.89 nM
Cc1c(C#N)c(=O)oc2cc(OCc3ccccc3)ccc12 CHEMBL4095676 IC50 1.9 nM
Cc1c(C)c2ccc(OCc3ccccc3C#N)cc2oc1=O CHEMBL342327 pIC50 1.95 nM
N#CCCn1nnc(-c2ccc(OCc3ccccc3)cc2)n1 CHEMBL434261 IC50 2.0 nM
O=c1ccoc2ccc(OCc3ccc(Cl)cc3)cc12 CHEMBL1945153 IC50 2.0 nM
O=c1ccoc2ccc(OCc3cccc(Br)c3)cc12 CHEMBL1945154 IC50 2.0 nM
O=c1ccoc2ccc(OCc3ccc(C(F)(F)F)cc3)cc12 CHEMBL1945272 IC50 2.0 nM
NC/C(=C/F)CCc1ccc(F)cc1 CHEMBL489079 IC50 2.0 nM
NC/C(=C/F)[C@@H]1Cc2ccccc2O1 CHEMBL5204901 IC50 2.0 nM
NC/C(=C\F)[C@@H]1Cc2ccccc2O1 CHEMBL5186190 IC50 2.0 nM
OCCn1nnc(-c2ccc(OCc3ccccc3)cc2)n1 CHEMBL145760 IC50 2.0 nM
OCCn1nnc(-c2ccc(OCc3cccc(Cl)c3)cc2)n1 CHEMBL141933 IC50 2.0 nM
O=C(/C=C/c1ccc(F)cc1)c1ccc2c(c1)OCCO2 CHEMBL5273404 IC50 2.0 nM
N/N=C/c1ccc(Cl)cc1 CHEMBL3415442 IC50 2.0 nM
C/C(=N/Nc1nc(-c2ccc(C#N)cc2)cs1)c1cccnc1 CHEMBL2151544 IC50 2.09 nM
O=C(CCc1ccccc1Br)Nc1nc2ccccc2c(=O)s1 CHEMBL2382429 IC50 2.09 nM
Cc1ccc2oc(=O)c(-c3ccc([N+](=O)[O-])cc3)cc2c1 CHEMBL3360732 IC50 2.1 nM
Cc1c(Cl)c(=O)oc2cc(OCc3ccccc3)ccc12 CHEMBL4094745 IC50 2.1 nM
Cc1c(C)c2ccc(OCc3cccc(Cl)c3)cc2oc1=O CHEMBL109018 pIC50 2.138 nM
N#CCCn1nc(-c2ccc(OCc3ccccc3)cc2)oc1=O CHEMBL17092 IC50 2.2 nM
FC(F)(F)c1ccc(Nc2ccnc3nc(-c4ncccc4C(F)(F)F)ccc23)nc1 CHEMBL1089119 INH 2.2 nM
Cc1ccc2oc(=O)c(-c3cccc(N)c3)cc2c1 CHEMBL3360734 IC50 2.2 nM
Cc1c(C#N)c(=O)oc2cc(OCc3ccc(F)cc3)ccc12 CHEMBL4082300 IC50 2.2 nM
C#CCN(C)CCCOc1ccc(Cl)cc1Cl CHEMBL8706 IC50 2.2 nM
Cn1ccc2cc(C(=O)Nc3ccc(Cl)c(Cl)c3)ccc21 CHEMBL3319269 IC50 2.26 nM
Cc1c(C)c2ccc(OCc3ccc(C#N)cc3)cc2oc1=O CHEMBL145792 pIC50 2.344 nM
O=C(Nc1cnc(Cl)c(Cl)c1)c1ccc2[nH]ncc2c1 CHEMBL3319254 Ki 2.39 nM
O=C1OCc2ccc(OCc3ccc(Br)cc3)cc21 CHEMBL2391740 IC50 2.4 nM
COC1CCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)C1 CHEMBL5191709 IC50 2.5 nM
COc1cccc(Cn2ccc3c(N4CCC(O)CC4)nc4ccccc4c32)c1 CHEMBL5177167 IC50 2.5 nM
C/C(=N/Nc1nc(-c2ccc(F)cc2)cs1)c1ccncc1 CHEMBL2151669 IC50 2.54 nM
COc1ccc2c(c1)O/C(=C\c1cc3ccccc3[nH]1)C2=O CHEMBL5265848 IC50 2.6 nM
COc1ccc2c(c1)O/C(=C\n1ccc3ccccc31)C2=O CHEMBL5278614 IC50 2.6 nM
C#CCCCCOc1ccc2ccc(=O)oc2c1 CHEMBL3121790 IC50 2.62 nM
Cc1cccc(NC(=O)c2coc3ccccc3c2=O)c1 CHEMBL4575130 IC50 2.65 nM
Cc1ccc2occ(C(=O)Nc3cccc(Cl)c3)c(=O)c2c1 CHEMBL4060916 Ki 2.69 nM
O=C1CCc2ccc(OCc3cccc(Br)c3)cc2N1 CHEMBL2430707 Ki 2.7 nM
NS(=O)(=O)c1ccc(-c2nnc(-c3ccc(Cl)c(Cl)c3)o2)cc1 CHEMBL4439402 IC50 2.7 nM
O=C1CSc2cc(OCc3ccc(Cl)cc3)ccc2N1 CHEMBL5199383 IC50 2.7 nM
COc1ccc(-c2cc3cc(C)ccc3oc2=O)cc1OC CHEMBL1835230 IC50 2.73 nM
O=C(Nc1cc(Cl)cc(Cl)c1)c1ccc2[nH]ncc2c1 CHEMBL3319246 IC50 2.75 nM
O=C(O)c1coc2ccc(OCc3cccc(Br)c3)cc2c1=O CHEMBL2062871 IC50 2.8 nM
O=C1OCc2ccc(OCc3ccc(Cl)cc3)cc21 CHEMBL2391739 IC50 2.8 nM
CC(=O)c1ccc(OCc2cccc(F)c2)cc1O CHEMBL3920226 IC50 2.8 nM
O=C(Nc1ccc(Cl)cc1)c1coc2ccccc2c1=O CHEMBL1814068 pIC50 2.884 nM
O=C1CCc2ccc(OCc3ccc(Br)cc3)cc2N1 CHEMBL3770377 IC50 2.9 nM
COCC1CN(c2noc3cc(OCCCC(F)(F)F)ccc23)[11C](=O)O1 CHEMBL5189391 Ki 2.9 nM
C[C@@H]1CC/C(=N/Nc2nc(-c3ccc(F)cc3F)cs2)C1 CHEMBL3264960 IC50 2.91 nM
C#CCCCCOc1ccc2cc(-c3ccc(OC)cc3)c(=O)oc2c1 CHEMBL3121792 IC50 2.96 nM
Fc1ccc(-c2csc(NN=C3CCCC3)n2)c(F)c1 CHEMBL1253680 IC50 3.0 nM
O=C1NC(=O)c2cc(OCc3ccc(Br)cc3)ccc21 CHEMBL1813523 Ki 3.0 nM
O=c1oc2cc(OCc3ccc(Cl)cc3)ccc2s1 CHEMBL3764447 IC50 3.0 nM
CC(=O)c1ccc(OCc2ccc(F)cc2)cc1O CHEMBL3948027 IC50 3.0 nM
O=C1Nc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2C1=O CHEMBL4460336 IC50 3.0 nM
Cc1ccccc1OC/C(=C/F)CN CHEMBL5199917 IC50 3.0 nM
NCC(=CF)C1Cc2ccccc2O1 CHEMBL5197971 IC50 3.0 nM
C/C(=N/Nc1nc(-c2ccc(F)cc2F)cs1)c1cccs1 CHEMBL2151678 IC50 3.01 nM
COc1ccc2c(=O)c(/C=C/c3ccc(F)cc3)coc2c1 CHEMBL4865050 IC50 3.1 nM
O=C(Nc1ccc(Cl)c(Cl)c1)C1=Cc2ccccc2OC1 CHEMBL1470839 IC50 3.16 nM
NNC(=O)c1cc2ccccc2oc1=O CHEMBL1830829 IC50 3.22 nM
Cc1cc(=O)oc2cc(OCc3cccc([N+](=O)[O-])c3)ccc12 CHEMBL145503 pIC50 3.236 nM
COc1cc(-c2cc3cc(C)ccc3oc2=O)ccc1Br CHEMBL1835232 IC50 3.25 nM
O=c1ccoc2ccc(OCc3ccc(Br)cc3)cc12 CHEMBL1945155 IC50 3.3 nM
CCc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1 CHEMBL4534643 IC50 3.31 nM
Cc1ccc(NC(=O)c2csc3ccccc3c2=O)cc1C CHEMBL4870887 IC50 3.35 nM
Clc1cccc(Cn2ccc3c(NC4CCOCC4)nc4ccccc4c32)c1 CHEMBL5206513 IC50 3.4 nM
Cc1ccc(/C=C/C(=O)c2ccc3c(c2)OCCO3)cc1 CHEMBL5275768 IC50 3.4 nM
COc1ccc(NC(=O)c2ccc3[nH]ncc3c2)cc1Cl CHEMBL3319250 IC50 3.42 nM
O=C1OCc2ccc(OCc3cccc(Br)c3)cc21 CHEMBL2391871 IC50 3.5 nM
Fc1ccc(-c2csc(NN=C3CCCCCC3)n2)cc1 CHEMBL1253845 pIC50 3.548 nM
Cc1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)cc1 CHEMBL1760716 Ki 3.56 nM
Cn1cc2cc(C(=O)Nc3ccc(F)c(Cl)c3)ccc2n1 CHEMBL4089754 Ki 3.57 nM
N[C@H]1C[C@]1(F)c1ccccc1 CHEMBL2094027 IC50 3.6 nM
O=c1ccoc2ccc(OCc3cccc(Cl)c3)cc12 CHEMBL1945152 IC50 3.6 nM
Cc1c(C)c2ccc(OCc3cccc(OC(F)(F)F)c3)cc2oc1=O CHEMBL145003 pIC50 3.631 nM
O=Cc1coc2ccc(OCc3cccc(Br)c3)cc2c1=O CHEMBL2062872 IC50 3.7 nM
Cc1ccc(-c2ccc3cc(OC[C@H](O)C[18F])ccc3n2)cn1 CHEMBL5181783 Kd 3.7 nM
Cc1ccc(COc2ccc3c(c2)C(=O)CCC3)cc1 CHEMBL5178689 IC50 3.8 nM
Fc1ccc(-c2csc(NN=C3CCCCC3)n2)cc1 CHEMBL1253699 pIC50 3.802 nM
COc1cccc(-c2csc(N/N=C(\C)c3cccnc3)n2)c1 CHEMBL1213915 IC50 3.81 nM
Cc1c(C)c2cc(O)c(OCc3ccccc3)cc2oc1=O CHEMBL142916 pIC50 3.89 nM
NCCNC(=O)c1ccc(Cl)cn1 CHEMBL279390 Ki 3.9 nM
COc1ccc2occ(C(=O)Nc3cccc(Cl)c3)c(=O)c2c1 CHEMBL4074532 IC50 3.94 nM
NC(=O)[C@@H]1CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1 CHEMBL3544912 pIC50 3.981 nM
O=C1Nc2ccc(/C=C/c3ccccc3)cc2C1=O CHEMBL466872 Ki 4.0 nM
CC(=O)c1ccc(OCc2cccc(Br)c2)cc1O CHEMBL2062878 IC50 4.0 nM
O=c1oc2cc(OCc3cccc(Cl)c3)ccc2s1 CHEMBL3763837 IC50 4.0 nM
CC(=O)c1ccc(OCc2ccc(Br)cc2)cc1O CHEMBL2062879 IC50 4.0 nM
O=C1COC(c2ccc(/N=N/c3ccccc3)cc2)=NN1 CHEMBL4071507 IC50 4.0 nM
C#CCN(C)CCCCCOc1ccc2c(c1)OCCC2=O CHEMBL4790537 IC50 4.0 nM
NCC(=CF)COc1ccc(F)cc1 CHEMBL5198317 IC50 4.0 nM
N#CCCn1nc(-c2ccc(OCc3ccccc3)cc2)o[11c]1=O CHEMBL5194743 IC50 4.0 nM
FC1(F)CCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)CC1 CHEMBL5200705 IC20 4.0 nM
COc1ccc(-c2cc3cc(Cl)ccc3oc2=O)cc1 CHEMBL2019154 IC50 4.0 nM
O=C(/C=C/C=C/c1ccccc1)c1ccco1 CHEMBL3193372 Ki 4.0 nM
Cc1ccc2oc(=O)c(-c3ccc(N)cc3)cc2c1 CHEMBL3360735 IC50 4.1 nM
C#CCNCc1cc2cc(OCc3ccccc3)ccc2[nH]1 CHEMBL45069 IC50 4.1 nM
O=C1CSc2cc(OCc3ccc(Br)cc3)ccc2N1 CHEMBL5174857 IC50 4.1 nM
c1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)cc1 CHEMBL1760717 Ki 4.21 nM
Cc1c(C)c2ccc(OCc3cccc(C(F)(F)F)c3)cc2oc1=O CHEMBL143555 pIC50 4.266 nM
O=c1[nH]c2ccc(OCc3ccccc3)cc2c(=O)o1 CHEMBL5218579 Ki 4.3 nM
COc1cc(NC(=O)c2ccc3[nH]ncc3c2)ccc1Cl CHEMBL3319252 IC50 4.36 nM
N#CCCn1nc(-c2ccc(OCc3ccccc3)cc2)oc1=S CHEMBL17079 IC50 4.4 nM
COc1ccc(C(=O)/C=C/c2ccc(Cl)cc2)c(O)c1 CHEMBL406861 IC50 4.4 nM
COc1ccc2c(c1)C/C(=C\c1ccc(Br)o1)C2=O CHEMBL5281646 IC50 4.4 nM
O=C1NC(=O)c2cc(SCc3ccccc3)ccc21 CHEMBL2158241 IC50 4.5 nM
CC1CC(=O)c2cnc(Nc3ccc(C#N)cc3)nc2C1 CHEMBL2408569 IC50 4.5 nM
O=C1CCCc2cc(OCc3cccc(I)c3)ccc21 CHEMBL3288298 IC50 4.5 nM
O=C1CCCc2cc(OCc3ccc(I)cc3)ccc21 CHEMBL3288299 IC50 4.5 nM
CCC(C)(C)c1ccc(OCCCN2CCCC2)cc1 CHEMBL4561401 IC50 4.5 nM
COc1ccc(C(=O)/C=C/C=C/c2ccc(Cl)cc2)c(O)c1 CHEMBL2332174 IC50 4.51 nM
O=C1c2ccccc2-c2nnc(-c3cccc(Cl)c3)cc21 CHEMBL339626 pIC50 4.571 nM
Clc1cccc(Cn2ccc3c(NCC4CCOC4)nc4ccccc4c32)c1 CHEMBL5187034 IC50 4.6 nM
C#CCNC1CCc2c(SCc3cccc(C(F)(F)F)c3)cccc21 CHEMBL4860050 IC50 4.7 nM
O=c1[nH]c2ccc(OCc3cccc(C(F)(F)F)c3)cc2c(=O)o1 CHEMBL5220869 IC50 4.7 nM
N#Cc1ccc(OCc2ccc(Br)cc2)cc1C#N CHEMBL2204752 IC50 4.8 nM
O=C(Nc1ccc2[nH]ccc2n1)c1ccc(Cl)c(F)c1 CHEMBL4450144 Ki 4.82 nM
Cc1ccc(COc2ccc3sc(=O)oc3c2)cc1 CHEMBL3763320 IC50 5.0 nM
C#CCN(C)[C@H](C)Cc1ccc(OCc2ccccc2)cc1 CHEMBL4239843 IC50 5.0 nM
O=C(/C=C/c1ccccc1)c1cccc(C(F)(F)F)c1 CHEMBL4865301 Ki 5.0 nM
NC/C(=C\F)[C@H]1Cc2ccccc2O1 CHEMBL5196906 IC50 5.0 nM
COc1cccc(Cn2ccc3c(NC4CCOCC4)nc4ccccc4c32)c1 CHEMBL5199814 IC50 5.0 nM
O=C1c2ccccc2-c2nnc(-c3ccc(F)c(F)c3)cc21 CHEMBL125921 pIC50 5.012 nM
O=C(/C=C/c1ccc(Cl)cc1)c1ccc(O)cc1O CHEMBL139679 pIC50 5.012 nM
C[C@@H]1CC/C(=N\Nc2nc(-c3ccc(F)cc3F)cs2)C1 CHEMBL3264959 IC50 5.06 nM
C/C(=N\NC(=O)c1cc(-c2ccccc2)on1)c1ccc(C)cc1 CHEMBL5171059 IC50 5.1 nM
Cc1ccc(/C=C2\Cc3cc(O)ccc3C2=O)cc1 CHEMBL3986834 IC50 5.2 nM
CN(CCO)c1nc2ccccc2c2c1ccn2Cc1cccc(Cl)c1 CHEMBL5187539 IC50 5.2 nM
O=C1/C(=C/c2ccc(Br)cc2)Cc2cc(O)ccc21 CHEMBL3950873 IC50 5.3 nM
C/C(=N/Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1)C1CC1 CHEMBL4174116 IC50 5.3 nM
C[C@@H]1CCC(=NNc2nc(-c3ccc(F)cc3F)cs2)C1 CHEMBL3350351 IC50 5.32 nM
O=C1c2ccccc2-c2nnc(-c3ccc(C(F)(F)F)cc3)cc21 CHEMBL127983 pIC50 5.37 nM
O=C(Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL3319242 Ki 5.48 nM
C#CCN(C)CC(=C)c1cccc(COc2ccc(F)cc2)c1 CHEMBL3415783 IC50 5.5 nM
Oc1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)c(O)c1 CHEMBL1760719 Ki 5.54 nM
O=C1NC(=O)c2cc(SCc3ccc(Cl)cc3)ccc21 CHEMBL2158242 IC50 5.6 nM
O=C1c2ccccc2-c2nnc(-c3cccc(Br)c3)cc21 CHEMBL127622 pIC50 5.623 nM
O=C1CC(O)Oc2ccc(OCc3cccc(Br)c3)cc21 CHEMBL2062882 IC50 5.7 nM
CN(Cc1ccc(C#N)cc1)Cc1ccc(COc2ccc3c(CO)cc(=O)oc3c2)cc1 CHEMBL3586611 IC50 5.7 nM
c1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)nc1 CHEMBL1760720 Ki 5.75 nM
CC(=O)N[C@H]1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1 CHEMBL3707394 IC50 5.9 nM
O=c1c(/C=C/c2ccc(Cl)cc2)coc2ccccc12 CHEMBL1241257 IC50 5.9 nM
COc1ccc(/C(C)=N/NC(=O)c2cc(-c3ccccc3)on2)cc1OC CHEMBL5198727 IC50 5.9 nM
COc1ccc2oc(=O)c(C(=O)Nc3ccccc3)cc2c1 CHEMBL4076698 IC50 5.95 nM
Cc1ccc(COc2ccc3occc(=O)c3c2)cc1 CHEMBL1945159 IC50 6.0 nM
O=C1CCCc2cc(OCc3ccc(C(F)(F)F)cc3)ccc21 CHEMBL3288303 IC50 6.0 nM
Cc1ccc2oc(=O)c(-c3cccc([N+](=O)[O-])c3)cc2c1 CHEMBL3360731 IC50 6.0 nM
CNC1CN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)C1 CHEMBL5419792 pIC50 6.026 nM
COc1ccc2c(=O)c(/C=C/c3ccc(N(C)C)cc3)coc2c1 CHEMBL4869187 IC50 6.1 nM
CC1CCC/C1=N\Nc1nc(-c2ccc(F)cc2F)cs1 CHEMBL3264954 IC50 6.16 nM
O=C1OCc2ccc(OCCCc3ccccc3)cc21 CHEMBL2391876 IC50 6.2 nM
O=C1CCc2ccc(OCc3cccc(Cl)c3)cc2N1 CHEMBL2430706 IC50 6.2 nM
O=C1c2ccccc2-c2nnc(-c3ccc4ccccc4c3)cc21 CHEMBL127982 pIC50 6.31 nM
O=C1OCc2ccc(OCc3ccc(F)cc3)cc21 CHEMBL2391741 IC50 6.4 nM
O=C1/C(=C/c2ccc(Cl)c(Cl)c2)CCc2ccc(O)cc21 CHEMBL5178423 IC50 6.4 nM
Cc1ccc(COc2ccc3[nH]c(=O)oc(=O)c3c2)cc1 CHEMBL5220277 IC50 6.4 nM
O=C1OCc2cc(OCc3ccc(C(F)(F)F)cc3)ccc21 CHEMBL3938837 IC50 6.41 nM
C#CCN(C)[C@H](C)Cc1ccccc1 CHEMBL1200904 IC50 6.59 nM
C#CC(C)N(C)[C@H](C)Cc1ccccc1 CHEMBL5170163 IC50 6.66 nM
NNC(N)=O CHEMBL903 IC50 6.7 nM
N#Cc1ccc(COc2ccc3c(c2)SCC(=O)N3)cc1 CHEMBL5174014 Ki 6.7 nM
O=C1NC(=O)c2cc(SCc3ccc(F)cc3)ccc21 CHEMBL2158244 IC50 6.8 nM
COc1ccc(/C=C/c2coc3cc(OC)ccc3c2=O)cc1 CHEMBL4865494 IC50 6.8 nM
O=C(Cn1c(=O)c(Cc2ccccc2)nc2ccccc21)NNC(=S)Nc1ccccc1 CHEMBL4852596 IC50 6.808 nM
NCCc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1 CHEMBL4210083 Ki 6.88 nM
O=c1[nH]c2ccc(OCc3ccc(Br)cc3)cc2c(=O)o1 CHEMBL5218784 IC50 6.9 nM
O=C1NC(=O)c2cc(OCCc3ccccc3)ccc21 CHEMBL1813519 Ki 7.0 nM
O=C1CCCc2cc(OCc3ccc(Cl)cc3)ccc21 CHEMBL3288295 IC50 7.0 nM
C[C@]1(N)C[C@@H]1c1ccccc1 CHEMBL3330339 IC50 7.0 nM
C#CCN1CCC(CCc2ccc(C(C)C)cc2)CC1 CHEMBL4558431 IC50 7.0 nM
CCOC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O CHEMBL1830814 IC50 7.01 nM
NC(=S)NNC(=O)Cn1c(=O)c(Cc2ccccc2)nc2ccccc21 CHEMBL4871376 IC50 7.087 nM
C/C(=N/Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1)C1CCCCC1 CHEMBL4166872 IC50 7.2 nM
O=C(Nc1ccc(F)cc1)c1coc2ccccc2c1=O CHEMBL4588031 IC50 7.3 nM
Oc1ccccc1C1CC(c2c3ccccc3cc3ccccc23)=NN1 CHEMBL1760718 Ki 7.35 nM
O=C1NC(=O)c2cc(SCc3ccc(Br)cc3)ccc21 CHEMBL2158243 IC50 7.4 nM
O=C1OCc2ccc(OCCOc3ccc(F)cc3)cc21 CHEMBL2391880 IC50 7.4 nM
Oc1ccc(C2CC(c3c4ccccc4cc4ccccc34)=NN2)cc1 CHEMBL1760714 Ki 7.51 nM
Cc1cccc(NC(=O)c2cc3cc(C)ccc3oc2=O)c1 CHEMBL494808 IC50 7.52 nM
CC(C)NNC(=O)c1ccncc1 CHEMBL92401 IC50 7.54 nM
CC(=O)N1N=C(c2ccc([N+](=O)[O-])cc2)O[C@@H]1c1ccc(Cl)c(Cl)c1 CHEMBL3770019 IC50 7.61 nM
N#Cc1ccc(OCc2ccccc2)cc1C#N CHEMBL2204753 IC50 7.9 nM
CC(=O)Nc1cccc(COc2ccc3c(C)c(C)c(=O)oc3c2)c1 CHEMBL439811 pIC50 7.943 nM
Cc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1 CHEMBL1643124 pIC50 7.943 nM
Cc1ccc(Nc2ncc3c(n2)CC(C)CC3=O)cc1 CHEMBL2408565 IC50 7.98 nM
N#CCCn1nc(-c2ccc(OCc3ccccc3)cc2)sc1=O CHEMBL16530 IC50 8.0 nM
O=C1CCCc2cc(OCc3ccc(F)cc3)ccc21 CHEMBL3288293 IC50 8.0 nM
O=c1ccoc2cc(OCc3ccc(C(F)(F)F)cc3)ccc12 CHEMBL3770875 IC50 8.0 nM
O=C1c2ccccc2-c2nnc(-c3ccc(Br)cc3)cc21 CHEMBL338094 pIC50 8.128 nM
C#CCN(C)Cc1ccccc1 CHEMBL673 IC50 8.2 nM
CN(CCCC(F)F)Cc1ccc(COc2ccc3c(CO)cc(=O)oc3c2)cc1 CHEMBL5082824 IC50 8.2 nM
Cc1ccc(COc2ccc3c(c2)SCC(=O)N3)cc1 CHEMBL5203446 IC50 8.2 nM
O=C(Nc1ccc(Cl)cc1)c1coc2cccc(O)c2c1=O CHEMBL5437543 IC50 8.3 nM
CC1CCC/C1=N\Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1 CHEMBL3264952 IC50 8.31 nM
O=C1c2ccccc2-c2nnc(-c3ccc([N+](=O)[O-])cc3)cc21 CHEMBL124935 pIC50 8.318 nM
O=C1OCc2cc(OCc3ccc(F)cc3)ccc21 CHEMBL3929816 IC50 8.35 nM
O=c1ccoc2ccc(OCc3ccc(F)cc3)cc12 CHEMBL1945157 IC50 8.4 nM
CN(C)c1ccc(/C=C2\COc3ccccc3C2=O)cc1 CHEMBL452001 IC50 8.51 nM
O=C1c2ccccc2-c2nnc(-c3cccc(C(F)(F)F)c3)cc21 CHEMBL127774 pIC50 8.511 nM
O=C1CCOc2cc(OCc3ccc(F)cc3)ccc21 CHEMBL1682819 IC50 8.6 nM
O=[N+]([O-])c1cccc(-c2csc(NN=C3CCCCCC3)n2)c1 CHEMBL4164415 IC50 8.6 nM
O=c1c(/C=C/c2ccc(F)cc2)coc2ccccc12 CHEMBL4876665 IC50 8.6 nM
O=C1/C(=C/c2ccc(O)cc2)COc2cc(O)cc(O)c21 CHEMBL1077616 IC50 8.61 nM
Cc1c(C)c2ccc(NC(=O)c3ccccc3)cc2oc1=O CHEMBL142738 pIC50 8.71 nM
Cc1c(Cl)c(=O)oc2cc(OCCCCS(=S)N3CCCCC3C)ccc12 CHEMBL5279129 IC50 8.9 nM
Cc1c(Cl)c(=O)oc2cc(OCCCCSC(=S)N3CCCCC3C)ccc12 CHEMBL5219522 IC50 8.9 nM
COc1cc(OC)cc(-c2cc3cc(C)ccc3oc2=O)c1 CHEMBL1783715 IC50 8.98 nM
O=c1c(=O)c2ccc(OCCCC(F)(F)F)cc2c1=O CHEMBL161907 IC50 9.0 nM
C[C@@H]1CCCC/C1=N\Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1 CHEMBL1243026 IC50 9.0 nM
Cc1ccc(COc2ccc3c(c2)C(=O)OC3)cc1 CHEMBL2391870 IC50 9.0 nM
O=C1CCCc2cc(OCc3cccc(Br)c3)ccc21 CHEMBL3288296 IC50 9.0 nM
O=C1CCCc2cc(OCc3ccc(Br)cc3)ccc21 CHEMBL3288297 IC50 9.0 nM
c1ccc2oc(C3=NCCN3)cc2c1 CHEMBL404505 Kd 9.0 nM
NCC(=CF)COc1ccccc1 CHEMBL5201033 IC50 9.0 nM
Clc1cccc(Cn2ccc3c(N4CC5(COC5)C4)nc4ccccc4c32)c1 CHEMBL5181534 IC50 9.0 nM
COc1ccc2oc(=O)c(C(=O)Nc3cccc(Cl)c3)cc2c1 CHEMBL4080704 IC50 9.03 nM
CC1CCC/C1=N\Nc1nc(-c2ccc(F)cc2)cs1 CHEMBL3264951 IC50 9.13 nM
COc1ccc2c(c1)C/C(=C\c1ccccc1)C2=O CHEMBL3902894 IC50 9.2 nM
CC1CC/C(=N\Nc2nc(-c3ccc(F)cc3F)cs2)C1 CHEMBL3264958 IC50 9.34 nM
N[C@@H]1C[C@H]1c1ccccc1 CHEMBL1179 IC50 9.4 nM
CC(=O)N1N=C(c2ccc([N+](=O)[O-])cc2)OC1c1ccc(Cl)c(Cl)c1 CHEMBL3770489 IC50 9.46 nM
CCOC(=O)c1cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2oc1=O CHEMBL1830817 IC50 9.47 nM
Clc1cccc(Cn2ccc3c(NC[C@H]4CCNC4)nc4ccccc4c32)c1 CHEMBL5404165 pIC50 9.55 nM
Cc1ccc(C2CC(c3ccccc3)=NN2C)cc1 CHEMBL2417762 IC50 9.6 nM
C[C@@H]1CCCC/C1=N/Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1 CHEMBL453703 IC50 9.8 nM
Cn1c(=O)c2c(nc(SCCc3ccc(Cl)cc3)n2C)n(C)c1=O CHEMBL2206107 Ki 9.8 nM
Cc1sc2nc(NC(=O)CCCc3ccccc3)sc(=O)c2c1C CHEMBL2382426 IC50 9.8 nM