NCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3818606 IC50 0.00715 nM
O=C(NOCCOCCOCCOCCN1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3819302 IC50 0.015 nM
O=C(NOCCNCCCCCC(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3818677 IC50 0.019 nM
O=C(NOCCO)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F CHEMBL2087076 EC50 0.2 nM
O=C(NOCCO)c1cc(CN2OCCCC2=O)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL1614766 Kd 0.24 nM
O=C(NOC[C@H](O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL507361 IC50 0.33 nM
O=C(NOC[C@H](O)CO)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F CHEMBL2087080 EC50 0.4 nM
CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 CHEMBL2103875 IC50 0.48 nM
O=C(CNCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)NCCCCCC(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1 CHEMBL3819622 IC50 0.5 nM
O=C(NOCCO)c1ccc2cnsc2c1Nc1ccc(I)cc1F CHEMBL2087461 EC50 0.6 nM
O=C(NOCC(O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL450775 IC50 0.6 nM
CC(=O)Nc1cccc(N2C(=O)N(C3CC3)C(=O)C3=C(Nc4ccc(I)cc4F)N(C)C(=O)C(C)C32)c1 CHEMBL5433950 IC50 0.7 nM
O=C(NOC[C@H](O)CO)c1ccc2cnsc2c1Nc1ccc(I)cc1F CHEMBL2087462 EC50 0.9 nM
O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1 CHEMBL2146883 IC50 0.9 nM
COc1cc2c(Nc3ccc(Sc4ncc(C)n4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL106489 IC50 1.0 nM
COc1cc(C[C@H]2C(=O)OC[C@@H]2Cc2ccc(OC)c(OC)c2)ccc1O CHEMBL435734 IC50 1.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 IC50 1.0 nM
COc1cc2c(Nc3ccc(Sc4ccccc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL29714 IC50 1.1 nM
CCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F CHEMBL2087082 EC50 1.3 nM
O=C(NOCC1CC1)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F CHEMBL2087081 EC50 1.5 nM
O=c1c2c(Nc3ccc(I)cc3F)cncc2cnn1C[C@H](O)CO CHEMBL3261161 IC50 1.63 nM
Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc21 CHEMBL1615025 IC50 1.79 nM
CC(C)NCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146893 IC50 1.8 nM
NC(=O)c1c(Oc2cccc(CNS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3746640 IC50 1.8 nM
O=C(NC[C@H](O)CO)c1ccncc1Nc1ccc(I)cc1F CHEMBL2107832 IC50 1.81 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CC[S+]([O-])CC1 CHEMBL105642 IC50 2.0 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Br)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL105220 IC50 2.0 nM
COc1cc2c(Nc3ccc(Sc4nc(C)c(C)n4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL102374 IC50 2.0 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL318804 IC50 2.0 nM
O=C(NOCC1CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl CHEMBL105442 IC50 2.0 nM
COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1668411 IC50 2.0 nM
O=C(NOCCO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL244488 IC50 2.0 nM
O=C(NOCCCO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL4588064 IC50 2.0 nM
COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL414139 IC50 2.4 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 2.5 nM
COc1cc2c(Nc3ccc(Cc4ccccc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL30728 IC50 2.7 nM
CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL1097700 IC50 2.8 nM
COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1077979 IC50 2.9 nM
CCN1CCN(CCCOc2cc3ncc(C#N)c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c3cc2OC)CC1 CHEMBL103045 IC50 3.0 nM
CCN(CC)CC/C=C/c1cc2ncc(C#N)c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c2cc1OC CHEMBL485615 IC50 3.0 nM
O=C(C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCC2)cc1)c1ccccc1)NCC(F)F CHEMBL3699139 IC50 3.0 nM
Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(OC[C@H](O)CO)cnc21 CHEMBL1684075 IC50 3.1 nM
Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@H](O)CO)cnc21 CHEMBL1684070 IC50 3.2 nM
Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(C(CO)CO)cnc21 CHEMBL1684074 IC50 3.3 nM
O=C(NOCCO)c1ccc2[nH]ncc2c1Nc1ccc(Br)cc1F CHEMBL2087079 EC50 3.4 nM
O=C(NOCCO)c1cc2ccoc2c(F)c1Nc1ccc(I)cc1F CHEMBL4229260 IC50 3.4 nM
O=C(NC[C@H](O)CO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3261144 IC50 3.41 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 3.5 nM
COc1cc2ncc(C#N)c(Nc3ccc(Cc4ccccc4)cc3)c2cc1OC CHEMBL31806 IC50 3.6 nM
Cc1c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc2n(C)c1=O CHEMBL1684067 IC50 3.8 nM
O=C(NOC[C@H](O)CO)c1cc2ccoc2c(F)c1Nc1ccc(I)cc1F CHEMBL4228425 IC50 3.9 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCCC1 CHEMBL323515 IC50 4.0 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1/C=C/CCN1CCN(C)CC1 CHEMBL524111 IC50 4.0 nM
Cc1c(Nc2ccc(I)cc2F)c2c(=O)n(CCO)cnc2n(C)c1=O CHEMBL1684073 IC50 4.0 nM
C[C@H](O)CONC(=O)c1oc2c(F)cncc2c1Nc1ccc(I)cc1F CHEMBL2087078 EC50 4.0 nM
COc1cc2c(Nc3ccc(Cc4ccsc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL30359 IC50 4.2 nM
COc1cc2c(Nc3ccc(Cc4cccs4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL288081 IC50 4.4 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc21 CHEMBL1684063 IC50 4.6 nM
C#Cc1ccc(Nc2c(F)c(=O)n(C)c3ncn(C[C@@H](O)CO)c(=O)c23)c(F)c1 CHEMBL1684069 IC50 4.8 nM
CC(C)(C)NCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146894 IC50 4.8 nM
CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C/[C@@H](C)[C@H](C)OC2=O CHEMBL3957257 IC50 4.8 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(CCCO)cnc21 CHEMBL1684062 IC50 4.9 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL322857 IC50 5.0 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1/C=C/CCO CHEMBL520025 IC50 5.0 nM
Cc1c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@H](O)CO)cnc2n(C)c1=O CHEMBL1684071 IC50 5.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCCN)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086072 IC50 5.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(I)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092178 IC50 5.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCC2)cc1)c1ccccc1 CHEMBL3699141 IC50 5.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccc(CO)cc3)cc1)cn2C1CCOC1 CHEMBL1976376 pKi 5.012 nM
CN(C)CC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146895 IC50 5.1 nM
C[C@H](N)C1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146898 IC50 5.2 nM
CCNc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\[C@H](C)[C@H](C)OC2=O CHEMBL2216826 IC50 5.2 nM
O=C(NOCCO)c1cc2c(c(F)c1Nc1ccc(I)cc1F)OCC2 CHEMBL4225654 IC50 5.7 nM
O=C(O)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl CHEMBL481949 IC50 5.73 nM
Cn1c(=O)c(Cl)c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc21 CHEMBL1681812 IC50 5.9 nM
NC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(Br)cc32)N1 CHEMBL361708 IC50 6.0 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1/C=C/CCCN1CCN(C)CC1 CHEMBL450271 IC50 6.0 nM
Nc1nc(C2CCNC(=O)c3[nH]c(Br)c(Br)c32)c[nH]1 CHEMBL151430 IC50 6.0 nM
CN(C)Cc1ccc(N/C(=C2\C(=O)Nc3cc(C#CC(=O)NCC(F)F)ccc32)c2ccccc2)cc1 CHEMBL3699138 IC50 6.0 nM
O=C(C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCC2)cc1)c1ccccc1)NCCF CHEMBL3699140 IC50 6.0 nM
O=C(NOC[C@@H](O)CO)c1cc2c(c(F)c1Nc1ccc(I)cc1F)OCC2 CHEMBL4226300 IC50 6.0 nM
COc1cc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC CHEMBL31733 IC50 6.2 nM
O=C(NOC[C@H](O)CO)c1oc2ccncc2c1Nc1ccc(I)cc1F CHEMBL2087077 EC50 6.3 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 6.31 nM
NCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146888 IC50 6.6 nM
Cn1cc(C(=O)NOCC2CC2)c(Nc2ccc(Br)cc2F)c(F)c1=O CHEMBL201629 IC50 6.8 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc(C#N)cc2)c1 CHEMBL288349 IC50 7.0 nM
CC(=O)c1cc(C(=O)N2CC(N)C2)c(Nc2ccc(I)cc2F)n1C CHEMBL1172521 IC50 7.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086065 IC50 7.0 nM
O=C(NOC[C@H](O)CO)c1cc2c(c(F)c1Nc1ccc(I)cc1F)OCC2 CHEMBL4225401 IC50 7.0 nM
CCNCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146892 IC50 7.2 nM
O=C(NOCCO)c1cc(CN2OCCC2=O)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL1684493 IC50 7.2 nM
O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)(CN2CCCC2)C1 CHEMBL2146896 IC50 7.6 nM
CC(C)(CO)ONC(=O)c1cc2ccoc2c(F)c1Nc1ccc(I)cc1F CHEMBL4228161 IC50 7.6 nM
O=C(NOCCO)c1ccc(F)c(F)c1Nc1ccc(Br)cc1F CHEMBL2335186 IC50 7.7 nM
O=C(NOCCCO)c1ccc(F)c(F)c1Nc1ccc(Br)cc1F CHEMBL4530560 IC50 7.7 nM
COc1cc2c(Nc3ccc(Sc4ccccn4)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL318326 IC50 8.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])c1 CHEMBL34184 IC50 8.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc([N+](=O)[O-])cc2)c1 CHEMBL36664 IC50 8.0 nM
N#C/C(=C(/N)Sc1ccccc1O)c1cccc(C(O)c2ccc(C#N)cc2)c1 CHEMBL35598 IC50 8.0 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C3CCOCC3)c2)ncc1Cl CHEMBL3884281 IC50 8.2 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(C[C@H](O)CO)cnc21 CHEMBL1684064 IC50 8.3 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(CCOC)c2)ncc1Cl CHEMBL3884839 IC50 8.5 nM
Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(CCO)cnc21 CHEMBL1684072 IC50 8.6 nM
CON(Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F)C(C)=O CHEMBL1684492 IC50 8.6 nM
Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2c1C(=O)CC2 CHEMBL2012893 IC50 8.9 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl CHEMBL3884229 IC50 8.9 nM
COc1cc2c(Nc3ccc(Sc4nccs4)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL102786 IC50 9.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2F)c(=O)oc2cc(OC(=O)N(C)C)c(F)cc12 CHEMBL3086078 IC50 9.0 nM
Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NOCCO)cc21 CHEMBL1614701 IC50 9.0 nM
Cn1cc(C(=O)NOCCO)c(Nc2ccc(Br)cc2F)c(F)c1=O CHEMBL372600 IC50 9.3 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2cccc(N3CCN(C(C)=O)CC3)c2)ncc1Cl CHEMBL3885421 IC50 9.5 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(CCCn3ccnc3)cc(O)c2C(=O)O[C@H]1C CHEMBL3900978 IC50 9.5 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(CCO)cnc21 CHEMBL1684061 IC50 9.8 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C)c2)ncc1Cl CHEMBL3884143 IC50 9.8 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c2cc1OCC CHEMBL321045 IC50 10.0 nM
COc1cc2cc3ncc(C#N)c(Nc4ccc(Oc5ccccc5)cc4)c3cc2cc1OC CHEMBL337728 IC50 10.0 nM
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(/C=C/CCN4CCCCC4)ccc23)cc1Cl CHEMBL485238 IC50 10.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 10.0 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 10.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2CCN(C)CC2)cc1)c1ccccc1 CHEMBL3699137 IC50 10.0 nM
CN(C)S(=O)(=O)Nc1cccc(Oc2cc(F)c(F)c(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL3747294 IC50 10.0 nM
Cn1c(=O)c(F)c(Nc2ccc(C#N)cc2F)c2c(=O)n(C[C@H](O)CO)cnc21 CHEMBL3644805 IC50 10.0 nM
Cn1c(=O)c(F)c(Nc2ccc(Br)cc2F)c2c(=O)n(C[C@H](O)CO)cnc21 CHEMBL3644807 IC50 10.0 nM
C#Cc1ccc(Nc2c(C)c(=O)n(C)c3ncn(C[C@@H](O)CO)c(=O)c23)c(F)c1 CHEMBL3644814 IC50 10.0 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(C(CO)CO)cnc21 CHEMBL3644815 IC50 10.0 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(OCCO)cnc21 CHEMBL3644816 IC50 10.0 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(OC[C@H](O)CO)cnc21 CHEMBL3644817 IC50 10.0 nM
Cn1c(=O)c(Cl)c(Nc2ccc(Br)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc21 CHEMBL3644818 IC50 10.0 nM
Cn1c(=O)c(Cl)c(Nc2ccc(Br)cc2F)c2c(=O)n(CCCO)cnc21 CHEMBL3644822 IC50 10.0 nM
CC(O)Cn1cnc2c(c(Nc3ccc(I)cc3F)c(Cl)c(=O)n2C)c1=O CHEMBL3644826 IC50 10.0 nM
Cc1c(Nc2ccc(I)cc2F)c2c(=O)n(C(CO)CO)cnc2n(C)c1=O CHEMBL3644828 IC50 10.0 nM
C#Cc1ccc(Nc2c(C)c(=O)n(C)c3ncn(C[C@H](O)CO)c(=O)c23)c(F)c1 CHEMBL3644829 IC50 10.0 nM
Cc1c(Nc2ccc(I)cc2F)c2c(=O)n(C)cnc2n(C)c1=O CHEMBL3644830 IC50 10.0 nM
O=C(NOC(CO)CO)c1cc2ccoc2c(F)c1Nc1ccc(I)cc1F CHEMBL4228999 IC50 10.8 nM
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(/C=C/CN4CCOCC4)ccc23)cc1Cl CHEMBL485237 IC50 11.0 nM
CC(=O)n1cc(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c1 CHEMBL1170802 IC50 11.0 nM
CC(=O)c1cc(C(=O)NOC[C@@H](O)CO)c(Nc2ccc(I)cc2F)n1C CHEMBL1170805 IC50 11.0 nM
Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOC[C@@H](O)CO)c2c1C(=O)CC2 CHEMBL2012894 IC50 11.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)N(C)C)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086066 IC50 11.0 nM
NCCS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL3746569 IC50 11.0 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2cccc(N3CCOCC3)c2)ncc1Cl CHEMBL3884616 IC50 11.0 nM
Cc1nn(C[C@H](O)CO)c(=O)c2c(Nc3ccc(I)cc3F)cncc12 CHEMBL3261162 IC50 11.4 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccncc2)c1 CHEMBL37493 IC50 12.0 nM
CCN1CCN(CC/C=C/c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(C#N)cnc3c2)CC1 CHEMBL489058 IC50 12.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 12.0 nM
C[C@@H](c1ccccc1)[C@@H](C(=O)Nc1ccc(I)cc1F)N1C(=O)N[C@H](c2ccc(OC[C@H](O)CO)cc2)C1=O CHEMBL1956073 IC50 12.0 nM
O=C(NOCCO)c1oc2ccncc2c1Nc1ccc(I)cc1F CHEMBL3330649 IC50 12.0 nM
CCS(=O)(=O)Nc1cccc(Oc2cc(F)c(F)c(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL3747066 IC50 12.0 nM
C[S+]([O-])CCONCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640630 IC50 12.0 nM
Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(C(=O)NOCCO)cc21 CHEMBL3187723 IC50 12.0 nM
O=c1c2c(Nc3ccc(I)cc3F)cncc2ncn1C[C@H](O)CO CHEMBL3261157 IC50 12.3 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2cccc(C#N)c2)c1 CHEMBL37911 IC50 13.0 nM
CC(=O)c1c(Cl)c(C(=O)NOC[C@@H](O)CO)c(Nc2ccc(I)cc2F)n1C CHEMBL1171013 IC50 13.0 nM
CC(=O)c1cc(C(=O)N2CC[C@@H](O)C2)c(Nc2ccc(I)cc2F)n1C CHEMBL1169631 IC50 13.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCC[C@@H](O)Cn1cccn1 CHEMBL2376674 IC50 13.0 nM
O=C(NC[C@H](O)CO)c1nc(Cl)ncc1Nc1ccc(I)cc1F CHEMBL3261153 IC50 13.0 nM
NC(=O)c1c(Oc2cccc(NS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3746736 IC50 13.0 nM
CCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL1097999 IC50 13.0 nM
COc1cc2c(Nc3ccc(Cc4ccoc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL30790 IC50 14.0 nM
COC(=O)c1ccc(C(O)c2cccc(/C(C#N)=C(\N)Sc3ccccc3N)c2)cc1 CHEMBL290865 IC50 14.0 nM
Cn1cc(C(N)=O)c(Nc2ccc(Br)cc2F)c(F)c1=O CHEMBL371693 IC50 14.0 nM
CC(=O)Nc1cccc(C(=O)Nc2cn3ncc(C#N)c(Nc4ccc(Oc5ccccc5)cc4)c3c2C)c1 CHEMBL202286 IC50 14.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 14.0 nM
Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2c1C(=O)CCC2 CHEMBL2012890 IC50 14.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(NS(N)(=O)=O)c1 CHEMBL2376666 IC50 14.0 nM
NC(=O)c1c(Oc2ccc(F)c(NS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3746559 IC50 14.0 nM
Cc1c(NS(N)(=O)=O)cccc1Oc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL3747047 IC50 14.0 nM
Cn1cc(C(=O)NO)c(Nc2ccc(Br)cc2F)c(F)c1=O CHEMBL203258 IC50 15.0 nM
CCS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL2376661 IC50 15.0 nM
CCNS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL3747136 IC50 15.0 nM
Cc1c(NS(N)(=O)=O)cccc1Oc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL3747256 IC50 15.0 nM
CCS(=O)(=O)Nc1cccc(Oc2c(F)c(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL3746467 IC50 15.0 nM
O=C(NOCCO)c1cc(COCC(O)CO)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3640621 IC50 15.0 nM
Cn1c(=O)c(F)c(Nc2ccc(Br)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc21 CHEMBL1684068 IC50 16.0 nM
C[C@@H](N)C1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146899 IC50 16.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCC[C@@H](O)Cn1ccnc1 CHEMBL2376675 IC50 16.0 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3884569 IC50 16.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2cccc([N+](=O)[O-])c2)c1 CHEMBL417687 IC50 17.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2cccs2)c1 CHEMBL284708 IC50 17.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccsc2)c1 CHEMBL38195 IC50 17.0 nM
Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOC[C@@H](O)CO)c2c1C(=O)CCC2 CHEMBL2012891 IC50 17.0 nM
COc1cc2c(Nc3ccc(Cc4ccccn4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL281662 IC50 18.0 nM
Cc1c(Nc2ccc(Br)cc2F)c(C(=O)NOCCO)cn(C)c1=O CHEMBL199860 IC50 18.0 nM
CNC(=O)Nc1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1C CHEMBL383108 IC50 18.0 nM
CC(=O)c1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n1C CHEMBL1169814 IC50 18.0 nM
CC(=O)c1c(Cl)c(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n1C CHEMBL1169999 IC50 18.0 nM
Cn1c(Nc2ccc(Br)cc2F)c(C(=O)NOCCO)c2c1C(=O)CCC2 CHEMBL2012896 IC50 18.0 nM
CC(C)S(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL2376662 IC50 18.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(NS(N)(=O)=O)c1Cl CHEMBL3747359 IC50 18.0 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 18.19 nM
CN1CCN(CC/C=C/c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(C#N)cnc3c2)CC1 CHEMBL520142 IC50 19.0 nM
CC(=O)c1cc(C(=O)NOC(CO)CO)c(Nc2ccc(I)cc2F)n1C CHEMBL1171012 IC50 19.0 nM
CC(=O)c1c(F)c(C(=O)NOC[C@@H](O)CO)c(Nc2ccc(I)cc2F)n1C CHEMBL1171015 IC50 19.0 nM
O=C(NOCCO)c1cc(CNOCCO)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL1684491 IC50 19.0 nM
O=C(NOCCO)c1cc(CNOCCCO)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3640626 IC50 19.0 nM
O=C(O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL2146885 IC50 19.5 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 19.95 nM
COc1cc2c(Nc3ccc(Cc4ccco4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL31143 IC50 20.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(F)c2F)cc1 CHEMBL214613 IC50 20.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)cc(Cl)c2)cc1 CHEMBL214734 IC50 20.0 nM
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(/C=C/CCN4CCCC4)ccc23)cc1Cl CHEMBL521502 IC50 20.0 nM
CC(=O)n1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c1C CHEMBL1169813 IC50 20.0 nM
CC(=O)c1cc(C(=O)NOC[C@H](O)CO)c(Nc2ccc(I)cc2F)n1C CHEMBL1170804 IC50 20.0 nM
Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOC[C@H](O)CO)c2c1C(=O)CCC2 CHEMBL2012892 IC50 20.0 nM
COc1cc2c(Nc3ccc(SC4CCCCC4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL282361 IC50 21.0 nM
CN(C)CC/C=C/c1ccc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2c1 CHEMBL485574 IC50 21.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(NS(=O)(=O)N2CCCC2)c1 CHEMBL2376664 IC50 21.0 nM
CN(C)S(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL2376663 IC50 21.0 nM
CS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL2375372 IC50 21.0 nM
CCS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086069 IC50 21.0 nM
O=S1(=O)Nc2c(cc(F)c(F)c2Nc2ccc(I)cc2F)OC[C@H](O)[C@H](O)CC12CC2 CHEMBL3884776 IC50 21.0 nM
O=C(NOCCO)c1cc(COCCO)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL464238 IC50 21.0 nM
O=C(NOCCO)c1cc2c(c(Cl)c1Nc1ccc(I)cc1F)OCC2 CHEMBL4225180 IC50 21.5 nM
N/C(=N\CCC(O)CO)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL263039 EC50 22.0 nM
CNS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL2376665 IC50 22.0 nM
NC(=O)c1c(Oc2cccc(CS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3746031 IC50 22.0 nM
COC(=O)Nc1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1C CHEMBL201389 IC50 23.0 nM
CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4OC)cc3)c2c1C CHEMBL377288 IC50 23.0 nM
CCC(=O)c1csc(NC(=O)[C@H]([C@@H](C)c2ccccc2)N2C(=O)N[C@H](c3ccc(OCCO)cc3)C2=O)n1 CHEMBL2396994 IC50 23.0 nM
O=C(NOCCO)c1cc(COCCCO)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3640620 IC50 23.0 nM
Cc1ccccc1C(O)c1cccc(/C(C#N)=C(\N)Sc2ccccc2N)c1 CHEMBL290017 IC50 24.0 nM
COc1ccccc1Oc1ccc(Nc2c(C#N)cnn3cc(NC(=O)NCCN4CCOCC4)c(C)c23)cc1 CHEMBL202356 IC50 24.0 nM
Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n(C)c1=O CHEMBL3182621 Kd apparent 24.0 nM
COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(C#N)cnc2cc1OCCN1CCOCC1 CHEMBL95002 IC50 25.0 nM
N#C/C(=C(/N)Sc1ccccc1O)c1cccc(C(O)c2cccc([N+](=O)[O-])c2)c1 CHEMBL36307 IC50 25.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2cccnc2)c1 CHEMBL38321 IC50 25.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc3c(c2)OCCO3)c1 CHEMBL34072 IC50 25.0 nM
CCN(CC)CCC/C=C/c1ccc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2c1 CHEMBL483398 IC50 25.0 nM
O=C(NOCCO)c1c(Nc2ccc(I)cc2F)c(F)c(=O)n2c1CCC2 CHEMBL2012902 IC50 25.0 nM
C[C@H](CO)COc1ccc([C@H]2NC(=O)N([C@H](C(=O)Nc3ccc(I)cc3F)[C@@H](C)c3ccccc3)C2=O)cc1 CHEMBL2396995 IC50 25.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 IC50 25.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 25.12 nM
COc1cc2c(Nc3ccc(Oc4ccncc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL31497 IC50 26.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)c(F)c1 CHEMBL385446 IC50 26.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2ccccc2)cc1 CHEMBL437331 IC50 26.0 nM
CCN(CC)CC/C=C/c1ccc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2c1 CHEMBL484368 IC50 26.0 nM
Cn1cnc2c(c(Nc3ccc(I)cc3F)cc(=O)n2C)c1=O CHEMBL1684060 IC50 26.0 nM
O=C(NOCCO)c1ccc(F)c(F)c1Nc1ccc(Cl)cc1F CHEMBL2335185 IC50 26.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OC[C@@H]1CCCN1 CHEMBL2376676 IC50 26.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4nccs4)cc3oc2=O)c1F CHEMBL3092176 IC50 26.0 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C(F)F)c2)ncc1Cl CHEMBL3884642 IC50 26.0 nM
O=C(NOCCCO)c1ccc(F)c(F)c1Nc1ccc(Cl)cc1F CHEMBL4590482 IC50 26.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(Cl)c2Cl)c(Cl)c1 CHEMBL214614 IC50 27.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(F)cc(F)c2Cl)c(F)c1 CHEMBL387184 IC50 27.0 nM
O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)(CO)C1 CHEMBL2146890 IC50 27.0 nM
Cc1c(Cc2cccc(N3CCCS3(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3400287 IC50 27.1 nM
Cc1c(Cc2cccc([N+](=O)[O-])c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3402993 IC50 27.7 nM
COc1cc2c(Nc3ccc(Sc4nccn4C)c(C)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL321078 IC50 28.0 nM
CC(O)C/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL385905 IC50 28.0 nM
CC(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL2376684 IC50 28.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086064 IC50 28.0 nM
NC(=O)c1c(Oc2ccc(F)c(NS(N)(=O)=O)c2F)cc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3746103 IC50 28.0 nM
CNC(=O)CONCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640627 IC50 28.0 nM
COCC(=O)N(Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F)OC CHEMBL3640635 IC50 28.0 nM
COc1cc2c(Nc3ccc(Cc4cccnc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL287852 IC50 29.0 nM
COc1cccc(Oc2ccc(Nc3c(C#N)cnn4cc(NC(=O)NCCN5CCOCC5)c(C)c34)cc2)c1 CHEMBL414856 IC50 29.0 nM
CC(=O)c1c(F)c(C(=O)NOC[C@H](O)CO)c(Nc2ccc(I)cc2F)n1C CHEMBL1171014 IC50 29.0 nM
O=C(NOCCO)c1c(Nc2ccc(I)cc2F)cc(=O)n2c1CCC2 CHEMBL2012907 IC50 29.0 nM
Cc1c(Cc2cccc(NS(C)(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086068 IC50 29.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(C)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092179 IC50 29.0 nM
CCC(=O)N(Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F)OC CHEMBL3640632 IC50 29.0 nM
O=C(NOCCCO)c1cc2ccoc2c(F)c1Nc1ccc(I)cc1F CHEMBL4225400 IC50 29.8 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccccc2)c1 CHEMBL37487 IC50 30.0 nM
Cn1cc(C(=O)O)c(Nc2ccc(Br)cc2F)c(F)c1=O CHEMBL203417 IC50 30.0 nM
Cn1cc(C(=O)NOCCO)c(Nc2ccc(Br)cc2F)cc1=O CHEMBL199749 IC50 30.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(F)cc(C(F)(F)F)c2)cc1 CHEMBL425980 EC50 30.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL215193 IC50 30.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(F)ccc2Cl)c(Cl)c1 CHEMBL269696 IC50 30.0 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1-c1ccc2c(C3CCNCC3)noc2c1 CHEMBL485286 IC50 30.0 nM
CC(=O)c1cc(C(=O)N2CC(O)C2)c(Nc2ccc(I)cc2F)n1C CHEMBL1170191 IC50 30.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F CHEMBL3264002 Kd apparent 30.0 nM
O=C(NC[C@@H](O)CO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3259833 IC50 30.2 nM
CS(=O)(=O)CCOCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640622 IC50 31.0 nM
O=C(NC(CO)CO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3261150 IC50 31.3 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 31.62 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 31.62 nM
N/C(=N\N1CCOCC1)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL214901 IC50 32.0 nM
CC(=O)c1c(Cl)c(C(=O)NOC[C@H](O)CO)c(Nc2ccc(I)cc2F)n1C CHEMBL1171682 IC50 32.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)c3c(n2C)C(=O)CCC3)c(F)c1 CHEMBL2012899 IC50 32.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(CS(N)(=O)=O)c1 CHEMBL2376667 IC50 32.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(NS(N)(=O)=O)c1Br CHEMBL3746537 IC50 32.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(COCCO)c(F)c2F)c(F)c1 CHEMBL3640619 IC50 32.0 nM
CS(=O)(=O)CCONCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640625 IC50 32.0 nM
COc1cc2c(Nc3ccc(CCc4ccccc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL30551 IC50 33.0 nM
CCONC(=O)c1cn(C)c(=O)c(F)c1Nc1ccc(Br)cc1F CHEMBL201426 IC50 33.0 nM
Cc1c(NC(=O)NCCN2CCOCC2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4F)cc3)c12 CHEMBL369992 IC50 33.0 nM
CN1CCN(CCC/C=C/c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(C#N)cnc3c2)CC1 CHEMBL489661 IC50 33.0 nM
O=c1c2c(Nc3ccc(I)cc3F)cncc2ncn1C[C@@H](O)CO CHEMBL3261158 IC50 33.6 nM
CN1CCN(/N=C(\N)c2c(O)nsc2Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)CC1 CHEMBL383858 IC50 34.0 nM
N/C(=N\CC1CCCO1)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL216449 IC50 34.0 nM
COc1ccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1 CHEMBL97714 IC50 35.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc(-c3nn[nH]n3)cc2)c1 CHEMBL35029 IC50 35.0 nM
N/C(=N\CCN1CCOCC1)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL214587 EC50 35.0 nM
N/C(=N\C(CO)CO)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL216325 IC50 35.0 nM
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(/C=C/CO)ccc23)cc1Cl CHEMBL519206 IC50 35.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)N3CCN(C)CC3)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086076 IC50 35.0 nM
CON(C=O)Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640631 IC50 35.0 nM
CON(Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F)C(=O)C(C)C CHEMBL3640633 IC50 35.0 nM
Cc1c(NC(=O)NCCN2CCOCC2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL378385 IC50 36.0 nM
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(/C=C/CCO)ccc23)cc1Cl CHEMBL485377 IC50 36.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)c3c(n2C)C(=O)CC3)c(F)c1 CHEMBL2012901 IC50 36.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccc2oc(=O)[nH]c2c1 CHEMBL2376660 IC50 36.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCCC#N)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086073 IC50 36.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2ccc(F)cc2Cl)c(Cl)c1 CHEMBL384784 EC50 37.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(F)cc(F)c2Cl)cc1 CHEMBL215038 IC50 37.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(CNS(N)(=O)=O)c1 CHEMBL3746923 IC50 37.0 nM
CC1(C)CON(Cc2cc(C(=O)NOCCO)c(Nc3ccc(I)cc3F)c(F)c2F)C1=O CHEMBL3640639 IC50 37.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1cccc(Cl)c1Cl CHEMBL375609 IC50 38.0 nM
Cc1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2n(c1=O)CCC2 CHEMBL2012908 IC50 38.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)c1F CHEMBL3092191 IC50 38.0 nM
Cn1cc(C(=O)NOCC2CC2)c(Nc2ccc(Br)cc2F)cc1=O CHEMBL201417 IC50 39.0 nM
O=C(NOC[C@H](O)CO)c1c(Nc2ccc(I)cc2F)c(F)c(=O)n2c1CCC2 CHEMBL2012905 IC50 39.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)CCCCl)c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3400285 IC50 39.2 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 39.81 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(Cc2ccccc2)c1 CHEMBL37871 IC50 40.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(Oc2ccccc2)c1 CHEMBL37504 IC50 40.0 nM
Cc1c(Nc2ccc(Br)cc2F)c(C(=O)NOCC2CC2)cn(C)c1=O CHEMBL201630 IC50 40.0 nM
CCC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL385059 IC50 40.0 nM
Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1-c1ccc2c(C3CCNCC3)noc2c1 CHEMBL485285 IC50 40.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(CN3OCCC3=O)c(F)c2F)c(F)c1 CHEMBL3640641 IC50 40.0 nM
C#Cc1ccc(Nc2c(C(=O)NOC[C@H](O)CO)c3c(n2C)C(=O)CCC3)c(F)c1 CHEMBL2012900 IC50 41.0 nM
Cc1c(NC(=O)c2ccccc2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL202063 IC50 42.0 nM
CC(C)/N=C(\N)c1c(O)nsc1Nc1ccc(I)cc1Cl CHEMBL213992 IC50 42.0 nM
CC(=O)c1cc(C(=O)O)c(Nc2ccc(I)cc2F)n1C CHEMBL1171312 IC50 42.0 nM
COc1cc2ncc(C#N)c(Nc3ccc(Oc4ccc(Cl)cc4)cc3)c2cc1OC CHEMBL31384 IC50 43.0 nM
CONC(=O)c1cn(C)c(=O)c(F)c1Nc1ccc(Br)cc1F CHEMBL201156 IC50 43.0 nM
N/C(=N\CCN1CCNCC1)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL214683 EC50 43.0 nM
CC(C)(O)C(O)CCOc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL2376673 IC50 43.0 nM
CON(Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F)C(=O)CO CHEMBL3640634 IC50 43.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2cccc(F)c2)c1 CHEMBL35379 IC50 44.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(I)cc1Cl CHEMBL213167 IC50 44.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(C(F)(F)F)c2)cc1 CHEMBL265478 IC50 44.0 nM
N/C(=N\CCN1CCNC(=O)C1)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL216832 IC50 44.0 nM
O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)C1 CHEMBL2146887 IC50 44.0 nM
Cc1c(Cc2ccc(F)c(NS(N)(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3092184 IC50 44.0 nM
Cn1cc(C(=O)NOCCO)c(Nc2ccc(Br)cc2F)c(Cl)c1=O CHEMBL199774 IC50 45.0 nM
CC(CO)NC(=N)c1c(O)nsc1Nc1ccc(Nc2ccccc2)cc1 CHEMBL253116 EC50 45.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Sc2ccccc2)cc1 CHEMBL386230 IC50 45.0 nM
N/C(=N\CCO)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL216833 IC50 46.0 nM
N/C(=N\CC(O)CO)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL384012 IC50 46.0 nM
CC(=O)c1cc(C(=O)NOCCCO)c(Nc2ccc(I)cc2F)n1C CHEMBL1169996 IC50 46.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCCO)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086074 IC50 46.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2cccc3ccccc23)c1 CHEMBL33906 IC50 47.0 nM
COCCNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086075 IC50 47.0 nM
COc1ccccc1Oc1ccc(Nc2c(C#N)cnn3cc(NC(=O)OCCN4CCOCC4)c(C)c23)cc1 CHEMBL265786 IC50 48.0 nM
CC(C)C(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL2376686 IC50 48.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(CN(OC)C(C)=O)c(F)c2F)c(F)c1 CHEMBL3640636 IC50 48.0 nM
CNC(=O)CCONCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640623 IC50 49.0 nM
O=C(NCCO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3261145 IC50 49.6 nM
Cc1ccc(C(O)c2cccc(/C(C#N)=C(\N)Sc3ccccc3N)c2)cc1 CHEMBL38315 IC50 50.0 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 50.12 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 50.12 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 50.12 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 51.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(C(F)(F)F)c2Cl)c(F)c1 CHEMBL217414 IC50 52.0 nM
CCN1CCN(C/C=C/c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(C#N)cnc3c2)CC1 CHEMBL521320 IC50 52.0 nM
Cn1c(Nc2ccc(Br)cc2F)c(C(=O)NOC[C@H](O)CO)c2c1C(=O)CCC2 CHEMBL2012898 IC50 52.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2cccc(C(F)(F)F)c2)c1 CHEMBL38260 IC50 53.0 nM
N#C/C(=C(/N)Sc1ccccc1)c1cccc(C(O)c2ccc(C#N)cc2)c1 CHEMBL284760 IC50 53.0 nM
N#C/C(=C(/N)Sc1ccc(N)cc1N)c1cccc(C(O)c2ccc(C#N)cc2)c1 CHEMBL417693 IC50 53.0 nM
Cn1c(=O)cc(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CCO)cnc21 CHEMBL1684065 IC50 53.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2F)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3092185 IC50 53.0 nM
Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOC[C@H](O)CO)c2c1C(=O)CC2 CHEMBL2012895 IC50 54.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccc2cn[nH]c2c1 CHEMBL2376683 IC50 54.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccoc2)c1 CHEMBL290886 IC50 55.0 nM
CN1CCN(C/C=C/c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(C#N)cnc3c2)CC1 CHEMBL485211 IC50 55.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)C2CCCCC2)c1 CHEMBL34601 IC50 56.0 nM
N/C(=N\OCC(O)CO)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL386469 IC50 56.0 nM
Cc1c(Cc2cccc(N)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086063 IC50 56.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCC(O)CO)cc(O)c2C(=O)O[C@H]1C CHEMBL3970061 IC50 56.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(CN3OCCCC3=O)c(F)c2F)c(F)c1 CHEMBL3640640 IC50 56.0 nM
O=C(NOCCNCCCCS(=O)(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL3819520 IC50 56.7 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc(C(F)(F)F)cc2)c1 CHEMBL38184 IC50 57.0 nM
Cc1cccc(C(O)c2cccc(/C(C#N)=C(\N)Sc3ccccc3N)c2)c1 CHEMBL37927 IC50 57.0 nM
N#C/C(=C(/N)Sc1ccc(N)cc1)c1cccc(C(O)c2ccccc2)c1 CHEMBL37634 IC50 57.0 nM
Cc1cc(Oc2ccc(F)cc2Cl)ccc1Nc1snc(O)c1/C(N)=N/C(C)CO CHEMBL424897 IC50 57.0 nM
O=C(NOCCO)c1c(Nc2ccc(I)cc2F)c(F)c(=O)n2c1CCCC2 CHEMBL2012903 IC50 57.0 nM
Cc1c(Cc2cccc(N(C)S(=O)(=O)CCCCl)c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3400286 IC50 57.5 nM
Cc1c(NC(=O)OCCN2CCOCC2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL204535 IC50 58.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Cc2ccccc2)cc1 CHEMBL217310 IC50 58.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(C(F)(F)F)c2F)cc1 CHEMBL217832 IC50 58.0 nM
CONS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086070 IC50 58.0 nM
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(/C=C/CN4CCCC4)ccc23)cc1Cl CHEMBL521013 IC50 59.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4nccs4)cc3oc2=O)c1 CHEMBL3092196 IC50 59.0 nM
COc1cc2ncc(C#N)c(Nc3cccc(Oc4ccccc4)c3)c2cc1OC CHEMBL30763 IC50 60.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(C(F)(F)F)ccc2F)cc1 CHEMBL217415 IC50 60.0 nM
CN(C)C(=O)Oc1ccc2c(CF)c(Cc3cccc(NS(N)(=O)=O)c3)c(=O)oc2c1 CHEMBL3092188 IC50 60.0 nM
O=C(NCCCO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3261146 IC50 60.1 nM
Cc1cc(I)ccc1Nc1snc(O)c1/C(N)=N/C(C)C CHEMBL211359 IC50 62.0 nM
O=C(NOCCO)c1cc2c(cc1Nc1ccc(I)cc1F)OCC2 CHEMBL4228687 IC50 62.8 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OC[C@H](O)CCO CHEMBL2376671 IC50 63.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCC[C@@H](O)CO CHEMBL2376668 IC50 63.0 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 63.1 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 63.1 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2ccc(Cl)cc2Cl)cc1 CHEMBL214816 IC50 64.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(F)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092192 IC50 64.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCC(F)(F)F)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086071 IC50 65.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(CN(OC)C(=O)CC)c(F)c2F)c(F)c1 CHEMBL3640637 IC50 65.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(CF)c3ccc(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092193 IC50 66.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(C(F)(F)F)c2Cl)c(Cl)c1 CHEMBL217126 IC50 67.0 nM
N#Cc1cnc2cc(OCCCN3CCOCC3)ccc2c1Nc1ccc(Oc2ccccc2)cc1 CHEMBL94965 IC50 68.0 nM
CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Cc4ccccc4)cc3)c2c1C CHEMBL202385 IC50 68.0 nM
CC(C)/N=C(\N)c1c(O)nsc1Nc1ccc(C(F)(F)F)cc1Cl CHEMBL377783 IC50 68.0 nM
CONCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640628 IC50 68.0 nM
CC(C)(O)CONCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640629 IC50 68.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)c3n(c(=O)c2F)CCC3)c(F)c1 CHEMBL2012906 IC50 69.0 nM
CC(O)(CO)CCOc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL2376672 IC50 69.0 nM
N#CC(=C(/N)Sc1ccccc1N)/C(C#N)=C(\N)Sc1ccccc1N CHEMBL34704 IC50 70.0 nM
C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(CN(OC)C(=O)C(C)C)c(F)c2F)c(F)c1 CHEMBL3640638 IC50 70.0 nM
N#CCN1CCC(n2cnc3cnc4cc(F)c(-c5ccc(Oc6ccccn6)cc5Cl)cc4c32)CC1 CHEMBL5090765 IC50 70.0 nM
CC(=O)n1cc(C(=O)O)c(Nc2ccc(I)cc2F)c1C CHEMBL1170596 IC50 72.0 nM
Cc1cc(I)ccc1Nc1snc(O)c1/C(N)=N/C(C)CO CHEMBL211201 IC50 73.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OC[C@@H]1CCCN1S(N)(=O)=O CHEMBL2376680 IC50 73.0 nM
COc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL2376669 IC50 74.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(Cl)c2Cl)cc1 CHEMBL214032 IC50 75.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc3ccccc3c2)c1 CHEMBL287959 IC50 76.0 nM
COc1cccc(Oc2ccc(Nc3c(C#N)cnn4cc(NC(=O)OCCN5CCOCC5)c(C)c34)cc2)c1 CHEMBL202177 IC50 76.0 nM
Cn1c(Nc2ccc(Br)cc2F)c(C(=O)NOC[C@@H](O)CO)c2c1C(=O)CCC2 CHEMBL2012897 IC50 76.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccnc1 CHEMBL2376682 IC50 76.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ccccc4)cc3oc2=O)c1F CHEMBL3263999 IC50 76.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 77.0 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3884960 IC50 78.0 nM
CCNc1cc(O)c2c(c1)/C=C/C[C@H](OC(=O)C(F)(F)F)[C@@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL3893740 IC50 79.0 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 79.43 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(F)ccc2Cl)cc1 CHEMBL214425 IC50 80.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccccc1NS(N)(=O)=O CHEMBL3746142 IC50 81.0 nM
CCONC(=O)c1cn(C)c(=O)c(C)c1Nc1ccc(Br)cc1F CHEMBL203138 IC50 82.0 nM
CC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146889 IC50 82.0 nM
CC(NS(N)(=O)=O)c1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL3747516 IC50 83.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2ccc(F)cc2Cl)cc1 CHEMBL215012 IC50 85.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(C#N)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092181 IC50 85.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(C(F)(F)F)cc1Cl CHEMBL213168 IC50 86.0 nM
CC(=O)Nc1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1C CHEMBL201819 IC50 87.0 nM
CC(=O)c1cc(C(=O)NCCCO)c(Nc2ccc(I)cc2F)n1C CHEMBL1169998 IC50 90.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCCO)cc(O)c2C(=O)O[C@H]1C CHEMBL1097699 IC50 91.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCCN3CCOCC3)cc(O)c2C(=O)O[C@H]1C CHEMBL3974111 IC50 91.0 nM
Cc1ccc(-c2nn(-c3ccccc3)cc2C(=O)NOCc2ccccc2F)cc1 CHEMBL4575118 IC50 91.0 nM
CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1C CHEMBL380765 IC50 94.0 nM
O=C(NOC[C@@H](O)CO)c1c(Nc2ccc(I)cc2F)c(F)c(=O)n2c1CCC2 CHEMBL2012904 IC50 94.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccc(F)c(NS(N)(=O)=O)c1 CHEMBL3747368 IC50 94.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(C(F)(F)F)c2Cl)cc1 CHEMBL217833 EC50 95.0 nM
O=c1c2c(Nc3ccc(I)cc3F)cncc2c(I)nn1C[C@H](O)CO CHEMBL3261164 IC50 95.0 nM
CCS(=O)(=O)N1CCC[C@H]1COc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL2376678 IC50 96.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCC[C@H](O)CO CHEMBL2376670 IC50 96.0 nM
CC(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL81277 IC50 96.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F CHEMBL3092195 IC50 97.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccccn2)c1 CHEMBL418230 IC50 99.0 nM
COc1ccc(Nc2c(C#N)cnc3cc(OCCCN4CCOCC4)c(OC)cc23)cc1 CHEMBL30516 IC50 99.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccccc1 CHEMBL2376681 IC50 99.0 nM
CNS(=O)(=O)Nc1cc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)ccn1 CHEMBL3263996 IC50 99.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCC(N)=O)cc(O)c2C(=O)O[C@H]1C CHEMBL3915384 IC50 99.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(C(=O)c2ccccc2)cc1 CHEMBL217130 EC50 100.0 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 pKi 100.0 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 100.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 100.0 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 100.0 nM
C#Cc1cc2c(C)c(Cc3cccc(NS(=O)(=O)NC)c3)c(=O)oc2cc1OC(=O)N(C)C CHEMBL3092180 IC50 100.0 nM
O=C(CCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)NO CHEMBL3967834 IC50 100.0 nM
O=C(CCCCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)NO CHEMBL3928172 IC50 100.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)CCc2ccc(S(=O)(=O)Nc3cc(C)c(=O)n(C)c3Nc3ccc(I)cc3F)cc2)C(C)(C)C)cc1 CHEMBL4473576 pIC50 100.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)CCc2ccc(S(=O)(=O)Nc3cc(C)c(=O)n(C)c3Nc3ccc(I)cc3F)cc2)C(C)(C)C)cc1 CHEMBL4528327 pIC50 100.0 nM
N#CCc1ccc(-n2cnc3cnc4cc(F)c(-c5ccc(Oc6ccccn6)cc5Cl)cc4c32)cc1 CHEMBL5094993 IC50 100.0 nM
CONC(=O)c1cn(C)c(=O)c(C)c1Nc1ccc(Br)cc1F CHEMBL426840 IC50 105.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(F)c1NS(N)(=O)=O CHEMBL3746158 IC50 107.0 nM
O=C(NOCCO)c1c(Nc2ccc(I)cc2F)c(Cl)c(=O)n2c1CCC2 CHEMBL2012909 IC50 109.0 nM
COc1cc2c(Nc3ccc(OC4CCCCC4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL31149 IC50 110.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092189 IC50 110.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)c(F)cc12 CHEMBL3092186 IC50 110.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)n1 CHEMBL3263995 IC50 110.0 nM
O=c1c2c(Nc3ccc(I)cc3F)cnc(Cl)c2ncn1C[C@H](O)CO CHEMBL3261159 IC50 112.0 nM
CNC(=O)c1cn(C)c(=O)c(F)c1Nc1ccc(Br)cc1F CHEMBL201691 IC50 118.0 nM
CN1CCN(CC/N=C(\N)c2c(O)nsc2Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)CC1 CHEMBL214977 EC50 118.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccc(F)c(NS(N)(=O)=O)c1F CHEMBL3746516 IC50 118.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccnn2C)ncc1Cl CHEMBL3590123 IC50 120.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCCn3ccnc3)cc(O)c2C(=O)O[C@H]1C CHEMBL3986872 IC50 120.0 nM
O=C(NOCCCO)c1ccc(F)c(F)c1Nc1ccc(F)cc1F CHEMBL4443751 IC50 120.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 120.0 nM
Cc1ncc2ncn(C[C@H](O)CO)c(=O)c2c1Nc1ccc(I)cc1F CHEMBL3261160 IC50 123.0 nM
Cn1cc(C(=O)NOCC2CC2)c(Nc2ccc(Br)cc2F)c(Cl)c1=O CHEMBL201379 IC50 124.0 nM
O=C(NOCCOCCOCCOCCNc1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL5084156 IC50 124.0 nM
COc1ccc2c(Nc3ccc(Oc4ccccc4)cc3)c(C#N)cnc2c1 CHEMBL98131 IC50 125.0 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 125.89 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 125.89 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 125.89 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 125.89 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccc2c(c1)N(S(N)(=O)=O)CCO2 CHEMBL3746203 IC50 127.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(F)cc(F)c2)cc1 CHEMBL215011 EC50 128.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(N(C)C)c2)cc1 CHEMBL413636 EC50 130.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 130.0 nM
COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1 CHEMBL1236682 Kd apparent 130.0 nM
Cc1ncc(Nc2ccc(I)cc2F)c(C(=O)NC[C@H](O)CO)n1 CHEMBL3261151 IC50 138.5 nM
N#CC(c1ccccc1)C(N)Sc1ccccc1N CHEMBL284774 IC50 140.0 nM
CC(=O)NCCONCc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F CHEMBL3640624 IC50 140.0 nM
CC(C)n1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 CHEMBL3753341 IC50 142.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3883384 IC50 142.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cccc(Cl)c2F)cc1 CHEMBL385203 IC50 145.0 nM
CCNc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(=O)O[C@@H]1C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL3948014 IC50 145.0 nM
Cc1c(C(=O)O)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL200969 IC50 147.0 nM
N/C(=N\CCCN1CCOCC1)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL214636 IC50 147.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(S(=O)(=O)c2ccccc2)cc1 CHEMBL217117 IC50 150.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2ccc(F)cc2F)cc1 CHEMBL214752 EC50 150.0 nM
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1 CHEMBL202721 pKi 158.49 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)COc2ccc(S(=O)(=O)Nc3cc(C)c(=O)n(C)c3Nc3ccc(I)cc3F)cc2)C(C)(C)C)cc1 CHEMBL4458609 pIC50 158.49 nM
COc1cc2ncc(C#N)c(Nc3ccc(Nc4ccccc4)cc3)c2cc1OC CHEMBL31639 IC50 160.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(OCc4ccccn4)c(Cl)c3)c3c(N)ncnc32)C1 CHEMBL4068839 IC50 161.0 nM
Cc1c(-c2nc3ccccc3[nH]2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL382616 IC50 168.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)Cc2ccccc2)c1 CHEMBL34436 IC50 170.0 nM
COCCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL3931700 IC50 172.0 nM
Cc1c(O)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL201251 IC50 181.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL401930 IC50 182.0 nM
CN1CCC[C@H]1COc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL2376677 IC50 182.0 nM
CCNc1cc(O)c2c(c1)C#CC[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL3940603 IC50 182.0 nM
O=C(NOCCOCCOCCOCCC(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL4127114 IC50 182.0 nM
CC(O)c1cccc(/C(C#N)=C(\N)Sc2ccccc2N)c1 CHEMBL35988 IC50 183.0 nM
COc1cc(OC)c2c(Nc3ccc(Oc4ccccc4)cc3)c(C#N)cnc2c1 CHEMBL97463 IC50 185.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NOC[C@H](O)CO)cc(O)c2C(=O)O[C@H]1C CHEMBL3898203 IC50 187.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(N3CCOC3=O)cc(O)c2C(=O)O[C@H]1C CHEMBL3922219 IC50 187.0 nM
COc1cc2c(Nc3ccc(Cc4ccncc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL30540 IC50 190.0 nM
Cc1c(N)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL203096 IC50 190.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ccccn4)cc3oc2=O)c1F CHEMBL3264000 IC50 190.0 nM
CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1COC CHEMBL382456 IC50 191.0 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 199.53 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 199.53 nM
COc1cc2c(Nc3ccc(CC4CCCCC4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL282976 IC50 200.0 nM
Cc1c(Cc2ccccc2)c(=O)oc2cc(OC(=O)C3CC3)ccc12 CHEMBL199006 IC50 200.0 nM
CC(C)/N=C(\N)c1c(O)nsc1Nc1ccc(I)c(Cl)c1 CHEMBL216500 IC50 200.0 nM
Cc1nnc(-c2ccc(-c3cc(NC(=O)c4ccnc(N5CCCC5)c4)ccc3C)c(C)c2)o1 CHEMBL495729 IC50 200.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 200.0 nM
CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1CO CHEMBL201186 IC50 203.0 nM
Cc1c(Cc2ccccc2N)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086062 IC50 210.0 nM
COc1cc2c(Nc3ccc(Cc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 CHEMBL320688 IC50 212.0 nM
CC(C)/N=C(\N)c1c(O)nsc1Nc1cccc(Cl)c1Cl CHEMBL213651 IC50 220.0 nM
CC(=O)n1cc(Nc2ccc(I)cc2F)c(C(=O)O)c1 CHEMBL1169746 IC50 220.0 nM
NC(=O)C1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 CHEMBL2146891 IC50 220.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3092182 IC50 230.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2)c(=O)oc2c(F)c(OC(=O)N(C)C)ccc12 CHEMBL3092187 IC50 240.0 nM
CCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C/[C@@H](C)[C@H](C)OC2=O CHEMBL3898540 IC50 240.0 nM
Cc1ccn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL201203 IC50 241.0 nM
N#Cc1c(O)nsc1Nc1ccc(Cl)cc1Cl CHEMBL385820 IC50 250.0 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 251.19 nM
Nc1n[nH]c2cccc(-c3ccc(F)cc3)c12 CHEMBL1971519 pKi 251.19 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 251.19 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 pKi 251.19 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccc(-c3nnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)n3)cc2)c1 CHEMBL430731 IC50 255.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccnn2C)ncc1C CHEMBL3590125 IC50 260.0 nM
Cc1ccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)cc1NS(N)(=O)=O CHEMBL3747610 IC50 262.0 nM
COc1cc(Nc2c(C#N)cnc3cc(-c4ccc(CN5CCOCC5)cc4)ccc23)c(Cl)cc1Cl CHEMBL322395 IC50 280.0 nM
COc1cc2ncc(C#N)c(Nc3ccc(SC)cc3)c2cc1OC CHEMBL30597 IC50 280.0 nM
Cc1cc(Nc2snc(O)c2/C(N)=N/C(C)CO)ccc1Oc1cc(F)ccc1Cl CHEMBL217416 IC50 280.0 nM
CN1CCN(CCC/N=C(\N)c2c(O)nsc2Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)CC1 CHEMBL386457 IC50 298.0 nM
N#CC(=C(/N)Sc1ccccc1O)/C(C#N)=C(\N)Sc1ccccc1O CHEMBL95069 IC50 300.0 nM
N#CC(=C(/N)Sc1cccs1)/C(C#N)=C(\N)Sc1cccs1 CHEMBL329492 IC50 300.0 nM
Cc1c(Cc2ccc(F)cc2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL78779 IC50 300.0 nM
Cc1ncnc(C(=O)NC[C@H](O)CO)c1Nc1ccc(I)cc1F CHEMBL3261154 IC50 314.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 316.23 nM
c1ccc(-c2c[nH]c3ncnc(N4CCCCC4)c23)cc1 CHEMBL1998953 pKi 316.23 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCC(=O)N(C)C)cc(O)c2C(=O)O[C@H]1C CHEMBL3914342 IC50 318.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 320.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(O)c2ccco2)c1 CHEMBL38216 IC50 323.0 nM
Cc1nn(C[C@@H](O)CO)c(=O)c2c(Nc3ccc(I)cc3F)cncc12 CHEMBL3261163 IC50 326.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 328.0 nM
C[n+]1ccc(C(O)c2cccc(/C(C#N)=C(\N)Sc3ccccc3N)c2)cc1 CHEMBL286239 IC50 330.0 nM
COc1ccc(NC(=O)[C@H]2SCCNC2=O)cc1 CHEMBL4795273 Kd 330.0 nM
CCOCc1c(C(=O)OCC)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL371969 IC50 331.0 nM
CC(C)(O)c1cccc(/C(C#N)=C(\N)Sc2ccccc2N)c1 CHEMBL35579 IC50 340.0 nM
NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1ccc(Cl)c(NS(N)(=O)=O)c1 CHEMBL3745994 IC50 345.0 nM
COC(=O)c1ccc(Nc2snc(O)c2C(=N)NCC2CCCCC2)cc1 CHEMBL377592 IC50 350.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(C(F)(F)F)ccc2Cl)cc1 CHEMBL217355 EC50 350.0 nM
C[C@]1(O)C[C@@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn32)C1 CHEMBL1091644 Kd apparent 352.0 nM
O=C(NOCCOCCOCCOCCN(CCO)c1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL5089694 IC50 352.0 nM
COc1cc(COCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)c([N+](=O)[O-])cc1OC CHEMBL5420851 IC50 353.2 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCCN3CCCC3)cc(O)c2C(=O)O[C@H]1C CHEMBL3973244 IC50 356.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCC3CCNCC3)cc(O)c2C(=O)O[C@H]1C CHEMBL3956374 IC50 356.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 360.0 nM
Cc1c(Nc2ccccc2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL201384 IC50 361.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCC(=O)O)cc(O)c2C(=O)O[C@H]1C CHEMBL3950457 IC50 366.0 nM
Cc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1NS(N)(=O)=O CHEMBL3747708 IC50 379.0 nM
O=C1C=CC(=O)c2ccccc21 CHEMBL55934 IC50 380.0 nM
O=C1C(Cl)=C(N2C(=O)CCC2=O)C(=O)c2ccccc21 CHEMBL404939 IC50 380.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCN(C)CCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C(C)(C)C)cc1 CHEMBL4780600 Kd 380.0 nM
Cc1c(C(=O)NCCN2CCOCC2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL201833 IC50 386.0 nM
Cc1ccc(C(O)c2cccc(/C(C#N)=C(\N)Sc3ccc(N)cc3)c2)cc1 CHEMBL38335 IC50 390.0 nM
CNC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1C CHEMBL202355 IC50 397.0 nM
COc1ccc2c(c1)c(-c1cc3nc(Br)cnc3[nH]1)cn2C CHEMBL2005478 pKi 398.11 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 398.11 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 398.11 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 398.11 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 398.11 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(F)ccc21 CHEMBL1993335 pKi 398.11 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 398.11 nM
Cc1cc(NS(=O)(=O)c2ccccc2)c(Nc2ccc(I)cc2F)n(C)c1=O CHEMBL4527608 pIC50 398.11 nM
N#CC(=C(/N)Sc1ccc(O)cc1)/C(C#N)=C(\N)Sc1ccc(O)cc1 CHEMBL94971 IC50 400.0 nM
Cc1nnc(-c2ccc(-c3cc(C(=O)Nc4cccc(N5CCOCC5)c4)ccc3C)c(C)c2)o1 CHEMBL523559 IC50 400.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCN(C)CCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C(C)(C)C)cc1 CHEMBL4741845 Kd 400.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCCNCCCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C(C)(C)C)cc1 CHEMBL4787502 Kd 400.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1cccc(C(=O)c2ccccc2)c1 CHEMBL422940 IC50 410.0 nM
N/C(=N\CC1CCCCC1)c1c(O)nsc1Nc1ccc(Cl)cc1Cl CHEMBL380328 IC50 410.0 nM
N#Cc1c(O)nsc1Nc1ccc(Cl)cc1 CHEMBL425065 IC50 410.0 nM
O=C(NOC[C@@H](O)CO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3261149 IC50 411.0 nM
N/C(=N\CC1CCCCC1)c1c(O)nsc1Nc1ccc(Cl)cc1 CHEMBL213563 IC50 420.0 nM
CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL3895505 IC50 421.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 428.0 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL221959 Kd apparent 429.0 nM
N/C(=N\CC1CCCCC1)c1c(O)nsc1Nc1ccc(Br)cc1 CHEMBL212110 IC50 430.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)nc3oc2=O)c1 CHEMBL3263994 IC50 440.0 nM
O=C(NOCCO)c1cc2c(c(F)c1Nc1ccc(Br)cc1Cl)OCC2 CHEMBL4227816 IC50 441.0 nM
COc1cccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL330388 IC50 450.0 nM
N#C/C(=C(/N)Sc1ccc(N)cc1)c1cccc(Cc2ccccc2)c1 CHEMBL37657 IC50 450.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCCN3CCN(C)CC3)cc(O)c2C(=O)O[C@H]1C CHEMBL3933684 IC50 471.0 nM
Cc1c(Cc2cccc(N(C)S(=O)(=O)CCCNCCCCCC(=O)N3CCN(c4nc(N5CCOCC5)nc(-n5c(C(F)F)nc6ccccc65)n4)CC3)c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3400291 IC50 473.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(N3CCNC3=O)cc(O)c2C(=O)O[C@H]1C CHEMBL3967300 IC50 484.0 nM
N#CC(=C(/N)Sc1ccccc1N)/C(C#N)=C(/N)Sc1ccccc1N CHEMBL100473 IC50 500.0 nM
N#CC(=C(/N)Sc1ccc(N)cc1)/C(C#N)=C(\N)Sc1ccc(N)cc1 CHEMBL317720 IC50 500.0 nM
N/C(=N\CC1CCCCC1)c1c(O)nsc1Nc1cccc(Br)c1 CHEMBL378719 IC50 500.0 nM
N/C(=N\CC1CCCCC1)c1c(O)nsc1Nc1cccc(Cl)c1 CHEMBL378014 IC50 500.0 nM
N#Cc1c(O)nsc1Nc1cccc(Br)c1 CHEMBL212214 IC50 500.0 nM
Cc1c(Cc2cccc(NC(=O)N(C)C)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086067 IC50 500.0 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 501.19 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 501.19 nM
NC(=O)c1cc2c(-c3ccc(Br)cc3)cncc2s1 CHEMBL1978195 pKi 501.19 nM
O=C(Cc1ccc(-c2cccnc2)cc1)Nc1ccc(SC(F)F)cc1 CHEMBL1992581 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 501.19 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 501.19 nM
Cc1cccc(C(O)c2cccc(/C(C#N)=C(\N)Sc3ccc(N)cc3)c2)c1 CHEMBL289134 IC50 503.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1ccccc1Oc1ccccc1 CHEMBL285905 IC50 510.0 nM
CC(C)/N=C(\N)c1c(O)nsc1Nc1ccc(I)cc1 CHEMBL209868 IC50 510.0 nM
O=C(NOCCO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3261147 IC50 513.2 nM
COc1ccc(Nc2c(C#N)cnc3cc(OC)c(OC)cc23)cc1 CHEMBL279758 IC50 520.0 nM
Cc1c(OCCN2CCOCC2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 CHEMBL201716 IC50 521.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 530.0 nM
O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CCC1 CHEMBL2146886 IC50 535.0 nM
CC(=O)Nc1ccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)cc1 CHEMBL2376685 IC50 539.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1ccc(C(=O)c2ccccc2)cc1 CHEMBL37548 IC50 540.0 nM
COc1cc2ncc(C#N)c(Nc3ccc(O)cc3)c2cc1OC CHEMBL30268 IC50 550.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 550.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F CHEMBL1230020 Kd 550.0 nM
C#Cc1nc(Nc2cccc(CC(N)=O)c2)nc2[nH]cnc12 CHEMBL4786783 IC50 550.0 nM
O=C(NOC[C@H](O)CO)c1ncncc1Nc1ccc(I)cc1F CHEMBL3261148 IC50 559.0 nM
CC(C)C(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2cc(Cl)ccc2Cl)cc1 CHEMBL216201 EC50 564.0 nM
CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1COCCOC CHEMBL201302 IC50 566.0 nM
COc1ccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)cc1NS(N)(=O)=O CHEMBL3747637 IC50 592.0 nM
N#Cc1c(O)nsc1Nc1cc(Cl)ccc1Cl CHEMBL209845 IC50 620.0 nM
N#Cc1cnc2cnc(NCCN3CCOCC3)cc2c1Nc1ccc(Cc2ccccc2)cc1 CHEMBL371658 IC50 630.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 pKi 630.96 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 630.96 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 630.96 nM
c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL482538 pKi 630.96 nM
CCn1nc(-c2ccccc2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL1488035 Potency 631.0 nM
CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccc(Cl)cc4)cc3)c2c1C CHEMBL203414 IC50 642.0 nM
N#Cc1c(O)nsc1Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL212305 IC50 650.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4cnccn4)cc3oc2=O)c1F CHEMBL3264001 IC50 650.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NC3CC3)cc(O)c2C(=O)O[C@H]1C CHEMBL3936269 IC50 657.0 nM
CNC(=O)CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL3912705 IC50 657.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCCNCC(O)CO)cc(O)c2C(=O)O[C@H]1C CHEMBL3970354 IC50 658.0 nM
Cc1ccccc1C(O)c1cccc(/C(C#N)=C(\N)Sc2ccc(N)cc2)c1 CHEMBL286371 IC50 659.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCCN(C)C)cs4)cc3c21 CHEMBL245884 IC50 660.0 nM
O=C1CCC(N2C(=O)c3ccc(NCCOCCOCCOCCOCCOCCNCCCONC(=O)c4ccc(F)c(F)c4Nc4ccc(I)cc4F)cc3C2=O)C(=O)N1 CHEMBL4744750 Kd 660.0 nM
COc1cc([N+](=O)[O-])ccc1Nc1snc(O)c1C(=N)NCC1CCCCC1 CHEMBL378688 IC50 670.0 nM
N#Cc1cnc2ccccc2c1Nc1ccc(Oc2ccccc2)cc1 CHEMBL98130 IC50 680.0 nM
CC(O)(c1ccccc1)c1cccc(/C(C#N)=C(\N)Sc2ccccc2N)c1 CHEMBL285661 IC50 682.0 nM
Cc1ccc(Nc2snc(O)c2C(=N)NCC2CCCCC2)c(C)c1 CHEMBL209502 IC50 690.0 nM
N#CC(=C1/Nc2ccccc2S1)/C(C#N)=C1\Nc2ccccc2S1 CHEMBL316510 IC50 700.0 nM
Cn1nc(-c2ccccc2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL1527391 Potency 707.9 nM
Cc1ccc(Nc2snc(O)c2C(=N)NCC2CCCCC2)cc1 CHEMBL212480 IC50 740.0 nM
CN(C)CCn1cnc2c(c(Nc3ccc(I)cc3F)cc(=O)n2C)c1=O CHEMBL1684066 IC50 740.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(N)=O)cs4)cc3c21 CHEMBL397332 IC50 750.0 nM
COCCOCCOCCNCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL3963562 IC50 756.0 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1C1CC1 CHEMBL3884914 IC50 763.0 nM
Cc1ncc(Nc2ccc(I)cc2F)c(C(=O)N[C@@H]2CCC[C@@H](O)[C@H]2O)n1 CHEMBL3261155 IC50 773.0 nM
N/C(=N\CC1CCCCC1)c1c(O)nsc1Nc1cc(Cl)cc(Cl)c1 CHEMBL378833 IC50 790.0 nM
Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL1334062 Potency 794.3 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 794.33 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 pKi 794.33 nM
COCOc1cccc(OCOC)c1-c1ccc(NS(C)(=O)=O)cc1C(=O)OC CHEMBL2004025 pKi 794.33 nM
Cc1ccc(-c2cc3c(NCCN)ccc(C(N)=O)c3[nH]2)cc1 CHEMBL1996048 pKi 794.33 nM
O=C1Nc2ccccc2C1=Cc1ccc[nH]1 CHEMBL1996176 pKi 794.33 nM
Nc1ncnc2scc(-c3ccccc3)c12 CHEMBL1975212 pKi 794.33 nM
CC(C)NC1=NNC(=O)C1=Cc1cc2ccccc2[nH]1 CHEMBL1988692 pKi 794.33 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 794.33 nM
N#Cc1cnc2cnc(NCCN3CCOCC3)cc2c1Nc1ccc(Oc2ccccc2)cc1 CHEMBL371095 IC50 800.0 nM
N#Cc1c(O)nsc1Nc1cc(Cl)cc(Cl)c1 CHEMBL212474 IC50 800.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCC(N)=O)cs4)cc3c21 CHEMBL246089 IC50 800.0 nM
O=C(NCCC(O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL2146884 IC50 801.0 nM
COc1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1C CHEMBL204094 IC50 805.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1 CHEMBL3092194 IC50 810.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCCNCCCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C(C)(C)C)cc1 CHEMBL4753440 Kd 820.0 nM
NC1=N/C(=C2/CCNC(=O)c3[nH]ccc32)C(=O)N1 CHEMBL255465 IC50 820.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 830.0 nM
C[C@@H]1/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(NCCNCCO)cc(O)c2C(=O)O[C@H]1C CHEMBL3954863 IC50 846.0 nM
COc1cc(CN(c2ccc(I)cc2F)c2c(C(=O)NOC[C@H](O)CO)ccc(F)c2F)c([N+](=O)[O-])cc1OC CHEMBL5430692 IC50 877.9 nM
CCn1nc(-c2cccs2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL555689 Potency 891.3 nM
Cc1ccc(NS(N)(=O)=O)cc1Oc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O CHEMBL3747496 IC50 899.0 nM
N#CC(=C(/N)Sc1ccccc1Cl)/C(C#N)=C(\N)Sc1ccccc1Cl CHEMBL97406 IC50 900.0 nM
N#CC(=C(/N)Sc1ccccc1F)/C(C#N)=C(\N)Sc1ccccc1F CHEMBL330393 IC50 900.0 nM
N#CC(=C(/N)Sc1ccccc1)/C(C#N)=C(\N)Sc1ccccc1 CHEMBL329698 IC50 900.0 nM
N#C/C(=C(/N)Sc1ccccc1N)c1ccc(Oc2ccccc2)cc1 CHEMBL37646 IC50 930.0 nM
Cc1c(Cc2cc(NS(N)(=O)=O)ccc2F)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3092183 IC50 940.0 nM
COc1cc(NS(N)(=O)=O)cc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1 CHEMBL3746690 IC50 941.0 nM
N#Cc1cnc2cnc(NCCN3CCOCC3)cc2c1Nc1ccc(Sc2ccccc2)cc1 CHEMBL199210 IC50 960.0 nM
CC(=O)NC[C@H]1CC[C@H](c2nc(-c3cc4ccccc4[nH]3)c3c(N)nccn32)CC1 CHEMBL1762110 IC50 960.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 968.0 nM
CC(C)(C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(Cl)c4)c(Cl)c3)c21)S(C)(=O)=O CHEMBL2148053 IC50 980.0 nM
Cc1c(Cc2cccc(N(C)S(=O)(=O)CCCNCCCC(=O)N3CCN(c4ccc(Nc5c(C(N)=O)cnc6ccc(-c7cnc8ccccc8c7)cc56)cc4C(F)(F)F)CC3)c2)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL5286229 IC50 980.0 nM