CC(Oc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cnc1N)c1ccccc1 CHEMBL3733088 Ki 0.06 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1C(F)(F)F CHEMBL3715238 Ki 0.17 nM
CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1C1CCN(CC#N)CC1 CHEMBL3716226 Ki 0.17 nM
CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1C1CCN(C)CC1 CHEMBL3355003 Ki 0.17 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(OC3CCC3)n2)c1 CHEMBL3393337 Ki 0.2 nM
Cn1ccnc1N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3729613 Ki 0.31 nM
CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3355005 Ki 0.4 nM
CC1N(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)CCC1(F)F CHEMBL3732543 Ki 0.4 nM
CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1C1CN(C2COC2)C1 CHEMBL3715325 Ki 0.48 nM
COCCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3730823 Ki 0.51 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3731122 Ki 0.52 nM
CC(Oc1cc(-c2cc(N3CCC3)nc(C3CC3)n2)cnc1N)c1nccs1 CHEMBL3732528 Ki 0.56 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CN4CC(F)F)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3728902 Ki 0.574 nM
CC1(Cn2nc(-c3cnc(N)c(C(F)(F)F)c3)cc2[C@H]2[C@@H]3CN(C4COC4)C[C@@H]32)CC1 CHEMBL3715788 Ki 0.67 nM
N#Cc1ccnc(Nc2cc(C3CN(C4COC4)C3)cc(N3CCC(F)(F)C3)n2)c1 CHEMBL3393334 Ki 0.7 nM
COCCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3733275 Ki 0.77 nM
N#Cc1ccnc(Nc2cc(C3CCOCC3)cc(N3CCC(F)(F)C3)n2)c1 CHEMBL3393329 Ki 0.9 nM
CC1CN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)CC1F CHEMBL3728441 Ki 0.9 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CN4CC(F)F)n2)C1 CHEMBL3732975 Ki 0.91 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@H]4C[C@H]43)n2)cc1OC(F)F CHEMBL3732447 Ki 0.92 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(C3CC3)n2)c1 CHEMBL3393340 Ki 1.0 nM
CC(=O)N1CCC(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CCC(F)(F)C3)c2)CC1 CHEMBL3393327 Ki 1.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(CC(F)F)C[C@@H]21 CHEMBL3717769 Ki 1.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1C1CCN(C2CCC2)CC1 CHEMBL3717104 Ki 1.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3731284 Ki 1.0 nM
CC(C)(O)CN1C[C@@H]2[C@H](C1)[C@@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3730273 Ki 1.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3732360 Ki 1.0 nM
COCC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3727397 Ki 1.0 nM
COC(C)(C)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3732912 Ki 1.0 nM
CC(C)(O)CN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3729148 Ki 1.0 nM
CC(C)(O)CN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3727449 Ki 1.0 nM
CC(C)(O)CN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3730912 Ki 1.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732012 Ki 1.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3727796 Ki 1.0 nM
CCC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3728651 Ki 1.09 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc([C@H]3C[C@@H](N4CCCOCC4)C3)n2)C1 CHEMBL3731609 Ki 1.14 nM
CC1CN(C2COC2)CCN1c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3728354 Ki 1.17 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCC3)n2)cc1C(F)(F)F CHEMBL3718810 Ki 1.2 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CCCC3)n2)cc1OC(F)F CHEMBL3729696 Ki 1.2 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)c1 CHEMBL3732684 Ki 1.25 nM
COCC(C)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1C(C)C CHEMBL3716760 Ki 1.3 nM
Cc1csc(C(C)Oc2cc(-c3cc(N4CCC4)nc(C4CC4)n3)cnc2N)n1 CHEMBL3730558 Ki 1.41 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3727385 Ki 1.47 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC(F)(F)F)n2)cc1C(F)(F)F CHEMBL3718522 Ki 1.6 nM
Nc1ncc(-c2cc(N3CCC4CC3CO4)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3731242 Ki 1.65 nM
CC(=O)N1C[C@@H]2CN(c3cc(-c4cnc(N)c(OC(F)F)c4)nc(C4CC4)n3)C[C@@H]21 CHEMBL3731498 Ki 1.76 nM
COCC1(F)CCN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC(F)(COC)C3)n2)C1 CHEMBL3733255 Ki 1.85 nM
CC(C)n1nc(-c2cnc(N)c(OC(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3719135 Ki 1.9 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1CC(F)(F)F CHEMBL3716725 Ki 1.9 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3CCN4CCC[C@H]4C3)n2)C1 CHEMBL3729681 Ki 1.92 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)cc(C3CC3)n2)cc1OC(F)F CHEMBL3728287 Ki 1.93 nM
CC(Oc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cnc1N)c1ccccn1 CHEMBL3728682 Ki 1.93 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C(F)(F)C4)n2)cc1OC(F)F CHEMBL3729085 Ki 1.99 nM
FC1(F)CCN(c2nc(Nc3cc(C(F)(F)F)ccn3)cc(C3CCNCC3)n2)C1 CHEMBL3393322 Ki 2.0 nM
CC(=O)N1C[C@@H]2[C@H](C1)[C@@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3729369 Ki 2.0 nM
Nc1ncc(-c2cc(N3CC4CC4C3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3728219 Ki 2.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4CC[C@H]3C4)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3727991 Ki 2.0 nM
CC1CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3731156 Ki 2.0 nM
CC(C)C(O)c1nc(-c2cnc(N)c(C(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 CHEMBL5287658 IC50 2.0 nM
CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(-c2cnc(N)c(OC(F)F)n2)cc(N2CCC(F)(F)C2)n1 CHEMBL5286166 IC50 2.0 nM
CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(-c2cnc(N)c(OC(F)F)n2)cc(N2CC3CC2C3)n1 CHEMBL5272522 IC50 2.0 nM
CC1CN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)CC1(F)F CHEMBL3729389 Ki 2.02 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3731916 Ki 2.06 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3733363 Ki 2.27 nM
CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1C1CCN(C2COC2)CC1 CHEMBL3718344 Ki 2.3 nM
Nc1ncc(-c2cc(N3CCC4(COC4)C3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3731405 Ki 2.3 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@H]4C[C@@H]3CO4)n2)C1 CHEMBL3732989 Ki 2.3 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc([C@H]3C[C@H](N4C[C@@H]5C[C@H]4CO5)C3)n2)C1 CHEMBL3732685 Ki 2.35 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CNC[C@@H]43)n(CC(F)(F)F)n2)cc1C(F)(F)F CHEMBL3719039 Ki 2.4 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc([C@H]3C[C@@H](N4CCOCC4)C3)n2)C1 CHEMBL3732366 Ki 2.59 nM
C[C@@H]1CCCN1c1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2C[C@@H]3C[C@H]2CO3)n1 CHEMBL3732536 Ki 2.62 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4OC[C@H]3C4F)n2)C1 CHEMBL3730695 Ki 2.62 nM
CCOC1(C)CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CC4CC3C4)n2)C1 CHEMBL3731453 Ki 2.67 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3717481 Ki 2.7 nM
CC(Oc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cnc1N)c1ccn(C)n1 CHEMBL3729535 Ki 2.73 nM
CC1=C(F)CN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3728098 Ki 2.84 nM
COCC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3731696 Ki 2.92 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3728798 Ki 2.96 nM
Nc1ncc(-c2cc(N3CCOCC3)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3727942 Ki 2.99 nM
Nc1ncc(-c2cc([C@@H]3[C@@H]4CN(C5COC5)C[C@@H]43)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3731011 Ki 3.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3727692 Ki 3.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC4C3)n2)cc1OC(F)F CHEMBL3727797 Ki 3.0 nM
CCn1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL4129958 Ki 3.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1OC(F)(F)F CHEMBL4125721 Ki 3.0 nM
CC(C)Cn1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL4128619 Ki 3.0 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(N3CCC(F)(F)C3)n2)c1 CHEMBL3393333 IC50 3.0 nM
COC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)F)n2)cc(N2CC3CC2C3)n1 CHEMBL5281494 IC50 3.0 nM
CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(SC)cc(-c2cnc(N)c(OC(F)F)n2)n1 CHEMBL5288706 IC50 3.0 nM
CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(-c2cnc(N)c(OC(F)F)n2)cc(C2CC2)n1 CHEMBL5283101 IC50 3.0 nM
COC1CC2CC1CN2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CCC(F)(F)C2)n1 CHEMBL3732966 Ki 3.08 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4)nc(C3CC3)n2)cc1OC(F)F CHEMBL3730790 Ki 3.1 nM
CC1(C)CN(C2CN(c3cc(-c4cnc(N)c(OC(F)F)c4)nc(N4CCC(F)(F)C4)n3)C2)CCO1 CHEMBL3732088 Ki 3.2 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCC3)n2)cc1OC(F)F CHEMBL3730236 Ki 3.22 nM
Nc1ncc(-c2cc(N3CC(N4CCCCC4=O)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732864 Ki 3.24 nM
Nc1ncc(-c2cc(N3CC4CC(C3)O4)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3728997 Ki 3.34 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CS4(=O)=O)n2)C1 CHEMBL3732383 Ki 3.34 nM
Nc1ncc(-c2cc(N3C[C@H]4C[C@@H]3CO4)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3731551 Ki 3.55 nM
Nc1ncc(-c2cc(C3CCC(N4CCOCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729943 Ki 3.57 nM
CO[C@@H](C)CN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3733341 Ki 3.65 nM
Cc1c[nH]c2ncc(-c3cc(C4CCN(C5COC5)CC4)n(C(C)C)n3)cc12 CHEMBL3718912 Ki 3.7 nM
CC(=O)N1CCC(c2cc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)nn2C(C)C)CC1 CHEMBL3718645 Ki 3.7 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3CCN4CCC[C@@H]4C3)n2)C1 CHEMBL3732793 Ki 3.74 nM
CC1C(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1(F)F CHEMBL3730040 Ki 3.77 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1OC(F)F CHEMBL3716545 Ki 3.9 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5CCOC5)C[C@@H]43)nc(C3CC3)n2)cc1OC(F)F CHEMBL3732998 Ki 3.91 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(C(F)F)C3)n2)cc1OC(F)F CHEMBL3732323 Ki 3.92 nM
COCCN1CC2CC(CC(c3cc(-c4cnc(N)c(OC(F)F)c4)nc(C4CC4)n3)C2)C1 CHEMBL3729832 Ki 3.96 nM
Cc1nc(Nc2cc(C(C)C)ccn2)cc(C2CCCN(C(=O)c3ccccc3)C2)n1 CHEMBL3393314 Ki 4.0 nM
CC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3732744 Ki 4.0 nM
CC(O)CN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1C(C)C CHEMBL4128889 Ki 4.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)nc1OC(F)F CHEMBL5271972 IC50 4.0 nM
Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3C[C@@H]4C[C@H]3CO4)c2)nc1OC(F)F CHEMBL5268969 IC50 4.0 nM
Cc1ccc(N2C[C@@H]3C[C@H]2CN3c2nc(-c3cnc(N)c(OC(F)F)n3)cc(N3CCC(F)(F)C3)n2)nn1 CHEMBL5271665 IC50 4.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3C[S+]4[O-])nc(N3CC[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3727899 Ki 4.05 nM
Nc1ncc(-c2cc(N3C[C@H]4CCO[C@H]4C3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3730967 Ki 4.07 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)C3)n2)cc1OC(F)F CHEMBL3730923 Ki 4.1 nM
COC1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CC4CC3C4)n2)C1 CHEMBL3730793 Ki 4.14 nM
CC(O)CN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3729007 Ki 4.18 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CC(N5CCOCC5)C[C@@H]43)nc(C3CC3)n2)cc1OC(F)F CHEMBL3733164 Ki 4.18 nM
COCCN1CCN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)C(C)C1 CHEMBL3730191 Ki 4.22 nM
Nc1ncc(-c2cc(C3CN(C4COC4)C3)cc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3732702 Ki 4.23 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(C3)CC4(F)F)n2)cc1OC(F)F CHEMBL3728386 Ki 4.32 nM
CC(CC#N)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1C(C)C CHEMBL3717559 Ki 4.4 nM
Nc1ncc(-c2cc(N3CCC(N4C[C@@H]5C[C@H]4CO5)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729960 Ki 4.47 nM
Nc1ncc(-c2cc(N3C[C@H]4C[C@@H]3CO4)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3730390 Ki 4.48 nM
CC(C)n1nc(-c2cnc(N)c(OC(F)F)c2)cc1[C@H]1[C@@H]2CN(CC(F)(F)F)C[C@@H]21 CHEMBL3715745 Ki 4.5 nM
Cc1c[nH]c2ncc(-c3cc(C4CCN(C5COC5)C4)n(C(C)C)n3)cc12 CHEMBL3715377 Ki 4.5 nM
CCc1cc([C@H]2[C@@H]3CN(CCO)C[C@@H]32)cc(-c2cnc(N)c(OC(F)F)c2)n1 CHEMBL3729605 Ki 4.52 nM
Nc1ncc(-c2cc(C3CC4CC(C3)CN(C3COC3)C4)nc(C3CC3)n2)cc1OC(F)F CHEMBL3733108 Ki 4.53 nM
Nc1ncc(-c2cc(N3CCC4(CCOC4)C3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3727508 Ki 4.58 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(-c3nccs3)n2)cc1OC(F)F CHEMBL3730276 Ki 4.63 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CC3)n2)cc1C(F)(F)F CHEMBL3717966 Ki 4.7 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cc1OC(F)(F)F CHEMBL3716708 Ki 4.7 nM
Nc1ncc(-c2cc(N3CCC(N4CCOCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732400 Ki 4.75 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(S(C)(=O)=O)C[C@@H]21 CHEMBL3714884 Ki 4.9 nM
Nc1ncc(-c2cc(N3CCOCC3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3727535 Ki 4.98 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC[C@H]3C(F)F)n2)cc1OC(F)F CHEMBL3727565 Ki 4.98 nM
Nc1ncc(-c2cc(N3CCC3)nc(C3CCC3)n2)cc1OC(F)F CHEMBL3731967 Ki 4.99 nM
CC(C)(O)c1cc(Nc2cc(C#N)ccn2)nc(N2CCC(F)(F)C2)c1 CHEMBL3393332 Ki 5.0 nM
N#Cc1ccnc(Nc2cc(C3(C#N)CCOCC3)cc(N3CCC(F)(F)C3)n2)c1 CHEMBL3393330 Ki 5.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3732123 Ki 5.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(CC3COC3)C[C@@H]21 CHEMBL4125824 Ki 5.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4)nc(N3CCC4(COC4)C3)n2)cc1OC(F)F CHEMBL3728623 Ki 5.01 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC=C(F)C3)n2)cc1OC(F)F CHEMBL3731104 Ki 5.1 nM
CC(Oc1cc(-c2cc(N3CCC3)nc(C3CC3)n2)cnc1N)c1ccccn1 CHEMBL3727660 Ki 5.35 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)nc3)cc(N3C[C@@H]4C[C@H]3CN4CC(F)F)n2)C1 CHEMBL3729886 Ki 5.35 nM
Nc1ncc(-c2cc(N3CCC(N4CCOCC4)C3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3728673 Ki 5.39 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCC3)n2)cc1OC(F)F CHEMBL3715482 Ki 5.5 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nn1C(C)C CHEMBL3718292 Ki 5.5 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(CC4)C3)n2)cc1OC(F)F CHEMBL3732434 Ki 5.55 nM
CC(C)OC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1C(C)C CHEMBL3716069 Ki 5.6 nM
CC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1C(C)C CHEMBL3718265 Ki 5.6 nM
Nc1ncc(-c2cc(N3CC(N4CCCC4=O)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3727721 Ki 5.72 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4)nc(C3CCOC3)n2)cc1OC(F)F CHEMBL3732209 Ki 5.74 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC[C@H]3CF)n2)cc1OC(F)F CHEMBL3727829 Ki 5.74 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)nn1C(C)C CHEMBL3715950 Ki 5.8 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CCC3)n2)cc1OC(F)F CHEMBL3730252 Ki 5.81 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCC(F)C3)n2)cc1OC(F)F CHEMBL3727681 Ki 5.83 nM
Nc1ncc(-c2cc(N3CCC4(CC3)COC4)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3729163 Ki 5.85 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(CCC#N)C[C@@H]21 CHEMBL3714894 Ki 5.9 nM
Nc1ncc(-c2cc(N3CCC3)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3728366 Ki 5.92 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3728626 Ki 6.19 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCC34CC4)n2)cc1OC(F)F CHEMBL3730513 Ki 6.2 nM
Nc1ncc(-c2cc(N3CC(N4CCC(F)CC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729772 Ki 6.21 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3728729 Ki 6.26 nM
Nc1ncc(-c2cc(N3CCN4CCCC4C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732217 Ki 6.26 nM
Nc1ncc(-c2cc(N3CC(N4C[C@@H]5C[C@H]4CO5)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3731062 Ki 6.34 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3CC(N4CCOCC4)C3)n2)C1 CHEMBL3731025 Ki 6.37 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC4CCC3C4)n2)cc1OC(F)F CHEMBL3728640 Ki 6.39 nM
CC(=O)N1CC(c2cc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)nn2C(C)C)C1 CHEMBL3717882 Ki 6.4 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4)nc(N3CC[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3731322 Ki 6.4 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3CCCOCC3)n2)C1 CHEMBL3733212 Ki 6.41 nM
Nc1ncc(-c2cc(N3C[C@H]4C[C@@H]3CO4)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3731770 Ki 6.49 nM
COC1(C)CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC3)n2)C1 CHEMBL3730391 Ki 6.6 nM
Nc1ncc(-c2cc(N3CC(F)C3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3730621 Ki 6.6 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@@H]4C[C@@H]43)n2)cc1OC(F)F CHEMBL3732667 Ki 6.67 nM
Nc1ncc(-c2cc(N3CC(N4CC[C@@H](F)C4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3730475 Ki 6.68 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3CC4F)n2)cc1OC(F)F CHEMBL3730808 Ki 6.68 nM
Nc1ncc(-c2cc([C@H]3CC[C@@H](N4CCOCC4)C3)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3727519 Ki 6.84 nM
CC1(CN2C[C@@H]3[C@H](C2)[C@H]3c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)COC1 CHEMBL3729547 Ki 6.85 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CCC(F)C3)n2)cc1OC(F)F CHEMBL3732707 Ki 6.85 nM
Nc1ncc(-c2cc([C@H]3CC[C@@H](N4CCOCC4)C3)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3730248 Ki 6.96 nM
FC1(F)CCN(c2nc(Nc3cc(C(F)(F)F)ccn3)cc(C3CCCNC3)n2)C1 CHEMBL3393321 Ki 7.0 nM
FC(F)(F)c1ccnc(Nc2cc(C3CCCNC3)nc(N3CCCC3)n2)c1 CHEMBL3393320 Ki 7.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3729567 Ki 7.0 nM
COc1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C(C)C)n2)cnc1N CHEMBL3715469 Ki 7.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3(F)F)n2)cc1OC(F)F CHEMBL3731763 Ki 7.03 nM
Cc1c[nH]c2ncc(-c3cc([C@H]4CCOC4)n([C@H]4CCC(F)(F)C4)n3)cc12 CHEMBL3718217 Ki 7.1 nM
Cc1c[nH]c2ncc(-c3cc([C@@H]4CCOC4)n([C@@H]4CCC(F)(F)C4)n3)cc12 CHEMBL3717622 Ki 7.1 nM
Cc1c[nH]c2ncc(-c3cc([C@@H]4CCOC4)n([C@H]4CCC(F)(F)C4)n3)cc12 CHEMBL3718463 Ki 7.1 nM
Cc1c[nH]c2ncc(-c3cc([C@H]4CCOC4)n([C@@H]4CCC(F)(F)C4)n3)cc12 CHEMBL3719179 Ki 7.1 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(C(F)(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3733168 Ki 7.1 nM
Nc1ncc(-c2cc(N3CCC3)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3729735 Ki 7.2 nM
Nc1ncc(-c2cc(N3CC[C@H](F)C3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3728901 Ki 7.21 nM
COC1CCN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CC4CC3C4)n2)C1 CHEMBL3732417 Ki 7.36 nM
CC1(F)CCN(c2cc(C3CN(C4COC4)C3)cc(-c3cnc(N)c(OC(F)F)c3)n2)C1 CHEMBL3728986 Ki 7.37 nM
Nc1ncc(-c2cc(N3CC(N4CC[C@H](F)C4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3731106 Ki 7.39 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cc1OC(F)F CHEMBL3719037 Ki 7.4 nM
C[C@@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3732198 Ki 7.53 nM
Nc1ncc(-c2cc(N3CCC(N4CCOCC4)C3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3732948 Ki 7.58 nM
Nc1ncc(-c2cc(N3CC(N4CCCOCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3730195 Ki 7.68 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1CC1CC1 CHEMBL3717538 Ki 7.9 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc([C@H]3C[C@H](N4CCOCC4)C3)n2)C1 CHEMBL3732496 Ki 7.96 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(-c3ccccn3)n2)cc1OC(F)F CHEMBL3731804 Ki 7.96 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(N3CCC3)n2)c1 CHEMBL3393336 Ki 8.0 nM
COC1CN(c2cc(C3CCN(C4COC4)CC3)cc(Nc3cc(C#N)ccn3)n2)C1 CHEMBL3393335 Ki 8.0 nM
CC(C)n1nc(-c2cnc(N)c(OC(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3714987 Ki 8.0 nM
CCC(=O)N1C[C@@H]2[C@H](C1)[C@@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3727659 Ki 8.0 nM
CC(C)Oc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cnc1N CHEMBL3729351 Ki 8.0 nM
Nc1ncc(-c2cc(N3CC(N4CC(F)C4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3730533 Ki 8.07 nM
Nc1ncc(-c2cc([C@H]3CC[C@H](N4CCOCC4)C3)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3731965 Ki 8.09 nM
Nc1ncc(-c2cc(N3C[C@@H]4OC[C@H]3C4F)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3727990 Ki 8.09 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CCC3)n2)cc1C(F)(F)F CHEMBL3714822 Ki 8.1 nM
Nc1ncc(-c2cc(N3CC(N4CCC(F)(F)C4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729121 Ki 8.16 nM
Nc1ncc(-c2cc(N3C[C@@H]4OC[C@H]3C4F)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3731117 Ki 8.19 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4(=O)=O)nc(N3CC[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3727946 Ki 8.2 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3728594 Ki 8.29 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CN4CC(F)F)nc(C3CC3)n2)cc1OC(F)F CHEMBL3728789 Ki 8.31 nM
Nc1ncc(-c2cc(N3CC[C@@H](F)C3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3732429 Ki 8.38 nM
COC1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)C1 CHEMBL3728459 Ki 8.44 nM
CN(C)C1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC(F)(F)C3)n2)C1 CHEMBL3729913 Ki 8.55 nM
Nc1ncc(-c2cc(N3CCC3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3727553 Ki 8.64 nM
Nc1ncc(-c2cc(N3C[C@H]4C[C@@H]3CO4)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3728516 Ki 8.65 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC(F)(F)C4C3)n2)cc1OC(F)F CHEMBL3729060 Ki 8.85 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cc1C(F)(F)F CHEMBL3718574 Ki 8.9 nM
CC(C)Oc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cnc1N CHEMBL3729103 Ki 9.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1C(C)C CHEMBL3716231 Ki 9.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CCCC3)n2)cc1C(F)(F)F CHEMBL4128477 Ki 9.0 nM
CC(C)n1nc(-c2cnc(N)c(C(C)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3718242 Ki 9.2 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4(=O)=O)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3731838 Ki 9.24 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3730817 Ki 9.26 nM
CC(C)(O)CN1CC(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)c2)C1 CHEMBL3732640 Ki 9.37 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(CC(F)F)n2)cc1OC(F)F CHEMBL3732918 Ki 9.52 nM
Nc1ncc(-c2cc([C@H]3C[C@@H](N4C[C@@H]5C[C@H]4CO5)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3727603 Ki 9.56 nM
FC(F)(F)c1c[nH]c2ncc(-c3cc([C@H]4CCOC4)n([C@@H]4CCOC4)n3)cc12 CHEMBL3716996 Ki 9.6 nM
FC(F)(F)c1c[nH]c2ncc(-c3cc([C@@H]4CCOC4)n([C@H]4CCOC4)n3)cc12 CHEMBL3717402 Ki 9.6 nM
FC(F)(F)c1c[nH]c2ncc(-c3cc([C@H]4CCOC4)n([C@H]4CCOC4)n3)cc12 CHEMBL3715815 Ki 9.6 nM
FC(F)(F)c1c[nH]c2ncc(-c3cc([C@@H]4CCOC4)n([C@@H]4CCOC4)n3)cc12 CHEMBL3719370 Ki 9.6 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3730483 Ki 9.6 nM
Nc1ncc(-c2cc(N3CC4(CCOC4)C3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3728681 Ki 9.65 nM
C[C@@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@H]4C[C@@H]3CO4)n2)C1 CHEMBL3732042 Ki 9.67 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4C(C3)C4(Cl)Cl)n2)cc1OC(F)F CHEMBL3731771 Ki 9.8 nM
CC(=O)N1CC(c2cc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)nn2CC2CC2)C1 CHEMBL3717492 Ki 10.0 nM
CC(C)(O)CN1C[C@@H]2[C@H](C1)[C@@H]2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3732808 Ki 10.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4(CCC4)C3)n2)cc1OC(F)F CHEMBL3731955 Ki 10.0 nM
COCCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3730836 Ki 10.0 nM
CC(C)(O)CN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3728240 Ki 10.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CN4C3COC3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3732271 Ki 10.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3729191 Ki 10.0 nM
CC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3732600 Ki 10.0 nM
CC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3727625 Ki 10.0 nM
CCC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3729672 Ki 10.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4CC[C@H]3C4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3732560 Ki 10.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cc1OC(F)(F)F CHEMBL3729719 Ki 10.0 nM
CC(Oc1cc(-c2cc(N3CCC3)nc(C3CC3)n2)cnc1N)c1ccn(C)n1 CHEMBL3730738 Ki 10.0 nM
Nc1ncc(-c2cc(N3CC(n4cccn4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732387 Ki 10.1 nM
CN(C1CCOC1)C1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC(F)(F)C3)n2)C1 CHEMBL3731139 Ki 10.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(C3)CC4(F)F)n2)cn1 CHEMBL3732465 Ki 10.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CCC3C4)n2)cc1OC(F)F CHEMBL3728371 Ki 10.2 nM
Nc1ncc(-c2cc(N3CC(N4CCCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3728693 Ki 10.3 nM
CC(C)c1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2C[C@@H]3C[C@H]2CO3)n1 CHEMBL3732320 Ki 10.4 nM
Nc1ncc(-c2cc([C@H]3C[C@@H](N4CCOCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732962 Ki 10.4 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(C3CN(C4COC4)C3)n2)C1 CHEMBL3733205 Ki 10.8 nM
Nc1ncc(-c2cc([C@H]3C[C@H](N4C[C@@H]5C[C@H]4CO5)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729751 Ki 10.9 nM
CC1(F)CCN(c2nc(-c3cnc(N)nc3)cc(N3C[C@@H]4C[C@H]3CN4CC(F)F)n2)C1 CHEMBL3732256 Ki 10.9 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCC3)n2)cc1C1CC1 CHEMBL3716550 Ki 11.0 nM
CC(C)Oc1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCC3)n2)cnc1N CHEMBL3717487 Ki 11.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(CC(C)(C)O)C[C@@H]21 CHEMBL3718678 Ki 11.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(Cl)c2)nn1CC(F)(F)F CHEMBL3718754 Ki 11.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)C3)cc(C3CC3)n2)cc1OC(F)F CHEMBL3732135 Ki 11.0 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc([C@H]2[C@@H]3CN(CC(C)O)C[C@@H]32)n1 CHEMBL3728116 Ki 11.1 nM
CC1(F)CCN(c2nc(-c3cnc(N)c(F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3728669 Ki 11.2 nM
Nc1ncc(-c2cc(N3CC(N4CCC(F)(F)CC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732758 Ki 11.3 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)cc(C3CC3)n2)cc1OC(F)F CHEMBL3728310 Ki 11.4 nM
COCCN1CC(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)c2)C1 CHEMBL3732627 Ki 11.4 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2CCC(C)(O)C2)n1 CHEMBL3730375 Ki 11.4 nM
CC1CC1c1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2C[C@@H]3C[C@H]2CO3)n1 CHEMBL3732231 Ki 11.5 nM
Nc1ncc(-c2cc(C3CC(O)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729651 Ki 11.7 nM
Nc1ncc(-c2cc(N3CCC3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3732260 Ki 11.9 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CC3)n2)cc1C(F)F CHEMBL3715814 Ki 12.0 nM
CC(=O)N1CCC(c2cc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)nn2C)CC1 CHEMBL3716132 Ki 12.0 nM
COCCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3731841 Ki 12.0 nM
C[C@H]1CCCN1c1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2C[C@@H]3C[C@H]2CO3)n1 CHEMBL3732140 Ki 12.0 nM
Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3CC4CC(C3)O4)n2)nc1OC(F)F CHEMBL5270353 IC50 12.0 nM
COC1(C)CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)C1 CHEMBL3727644 Ki 12.1 nM
CC1(O)CCN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)C1 CHEMBL3732343 Ki 12.9 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CCC3)n2)cc1OC(F)F CHEMBL3715610 Ki 13.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCC3)n2)cc1OC(F)(F)F CHEMBL3714846 Ki 13.0 nM
FC1(F)CCC(n2nc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)cc2C2CN(C3COC3)C2)C1 CHEMBL3718960 Ki 13.0 nM
FC1(F)CCC(n2nc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)cc2C2CCOC2)C1 CHEMBL3715873 Ki 13.0 nM
CC(c1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2C[C@@H]3C[C@H]2CO3)n1)C1CC1 CHEMBL3729883 Ki 13.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729443 Ki 13.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CCOCC3)n2)cc1OC(F)F CHEMBL3733034 Ki 13.0 nM
C[C@]1(F)CCN(c2nc(-c3cnc(N)c(Cl)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3731724 Ki 13.0 nM
Nc1ncc(-c2cc(N3CC4CC3C4)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F CHEMBL5276337 IC50 13.0 nM
CSc1cc(-c2cnc(N)c(OC(F)F)n2)nc(N2C[C@@H]3C[C@H]2CO3)n1 CHEMBL5268950 IC50 13.0 nM
Nc1ncc(-c2cc([C@@H]3CCCO3)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F CHEMBL5276415 IC50 13.0 nM
CC1CN(c2nc(-c3cnc(N)nc3)cc(N3C[C@@H]4C[C@H]3CO4)n2)CC1(F)F CHEMBL3728061 Ki 13.5 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3CC4(F)F)n2)cc1OC(F)F CHEMBL3733135 Ki 13.8 nM
COCCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3733343 Ki 13.9 nM
CC(C)(C#N)c1cc(Nc2cc(C#N)ccn2)nc(N2CCC(F)(F)C2)c1 CHEMBL3393331 Ki 14.0 nM
CC(C)Oc1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C(C)C)n2)cnc1N CHEMBL3714890 Ki 14.0 nM
Nc1ncc(-c2cc(N3CC4CC3CO4)nc(N3CC4CCOC4C3)n2)cc1OC(F)F CHEMBL3731594 Ki 14.0 nM
Nc1ncc(-c2cc(N3C[C@H]4CN(C5COC5)[C@H]4C3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3729051 Ki 14.0 nM
Nc1ncc(-c2cc(C3CC3)nc(N3C[C@@H]4C[C@H]3CO4)c2)nc1OC(F)F CHEMBL5277276 IC50 14.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(COC4)C3)n2)cc1OC(F)F CHEMBL3729863 Ki 14.3 nM
Nc1ncc(-c2cc(N3C[C@H]4COC[C@H]4C3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3730929 Ki 14.5 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4COC[C@@H]43)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3731707 Ki 14.8 nM
Nc1ncc(-c2cc([C@H]3C[C@H](N4CCOCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3733185 Ki 14.8 nM
CC(C)n1nc(-c2cnc3[nH]cc(Cl)c3c2)cc1C1CCN(C2COC2)CC1 CHEMBL3716456 Ki 15.0 nM
Cn1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1C1CCN(C2COC2)CC1 CHEMBL3714830 Ki 15.0 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2CC(F)C2)n1 CHEMBL3730465 Ki 15.2 nM
COCCN1CCN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)CC1C CHEMBL3733208 Ki 15.8 nM
Nc1ncc(-c2cc(N3CCC3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3732674 Ki 15.9 nM
Nc1ncc(-c2cc([C@H]3CC[C@H](N4CCOCC4)C3)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3732158 Ki 15.9 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cc1C(F)F CHEMBL3717490 Ki 16.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729976 Ki 16.2 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(c5nccs5)C[C@@H]43)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3729252 Ki 16.3 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@H]4COC[C@H]4C3)n2)cc1OC(F)F CHEMBL3732188 Ki 16.5 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cc1OC1CC1 CHEMBL3729112 Ki 16.7 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(CCOC4)C3)n2)cc1OC(F)F CHEMBL3733234 Ki 16.8 nM
Nc1ncc(-c2cc(N3CCC4(CC3)COC4)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3727844 Ki 16.9 nM
CC(c1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2C[C@@H]3C[C@H]2CO3)n1)C(F)(F)F CHEMBL3730871 Ki 16.9 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2CC(OC)C2)n1 CHEMBL3727767 Ki 17.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC(C(F)F)C3)n2)cc1OC(F)F CHEMBL3728939 Ki 17.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(CC3CC3(F)F)n2)cc1OC(F)F CHEMBL3731464 Ki 17.0 nM
Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F CHEMBL5284890 IC50 17.0 nM
C[C@@]1(F)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc([C@H]3C[C@@H](N4CCOCC4)C3)n2)C1 CHEMBL3731682 Ki 17.3 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3727618 Ki 17.9 nM
CCc1cc(C2CCN(C3COC3)CC2)cc(Nc2cc(C#N)ccn2)n1 CHEMBL3393339 Ki 18.0 nM
Cc1nc(Nc2cc(C3CC3)ccn2)cc(C2CCCN(C(=O)c3ccccc3)C2)n1 CHEMBL3393315 Ki 18.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCC3)n2)cc1Cl CHEMBL3716053 Ki 18.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cc1C(F)(F)F CHEMBL3730377 Ki 18.0 nM
Cc1nccn1-c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3728313 Ki 18.0 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc([C@H]2[C@@H]3CN(C4CCOC4)C[C@@H]32)n1 CHEMBL3731631 Ki 18.0 nM
COCCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(C2CC2)n1 CHEMBL3729524 Ki 18.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)CC3)n2)cc1OC(F)F CHEMBL3729721 Ki 18.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CCOC3)n2)cc1OC(F)F CHEMBL3730851 Ki 18.2 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 18.4 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3729553 Ki 18.8 nM
FC(F)(F)c1c[nH]c2ncc(-c3cc(C4CN(C5COC5)C4)n(C4CCOC4)n3)cc12 CHEMBL3715141 Ki 19.0 nM
CC(=O)N1CCC(c2cc(-c3cnc4[nH]cc(C)c4c3)nn2C(C)C)CC1 CHEMBL3717119 Ki 19.0 nM
Nc1ncc(-c2cc(N3CCC4(CCOC4)C3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3729505 Ki 19.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(Oc3ccccn3)c2)nc(C2CC2)n1 CHEMBL3729227 Ki 19.0 nM
CC(C)[C@H](O)c1nc(-c2cnc(N)c(OC(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 CHEMBL5420393 IC50 19.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3(C(F)(F)F)CC3)n2)cc1OC(F)F CHEMBL3728872 Ki 19.6 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc([C@H]2[C@@H]3CC(N4CCOCC4)C[C@@H]32)n1 CHEMBL3727513 Ki 19.8 nM
COc1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCC3)n2)cnc1N CHEMBL3719330 Ki 20.0 nM
Nc1ncc(-c2cc([C@@H]3[C@@H]4CN(C5COC5)C[C@@H]43)nc(N3CC4CC3C4)n2)cc1C(F)(F)F CHEMBL3729569 Ki 20.0 nM
Nc1ncc(-c2cc([C@@H]3[C@@H]4CN(C5COC5)C[C@@H]43)nc(N3CC4CC3C4)n2)cc1OC(F)(F)F CHEMBL3733015 Ki 20.0 nM
Nc1ncc(-c2cc([C@@H]3[C@@H]4CN(C5COC5)C[C@@H]43)nc(C3CC3)n2)cc1OC(F)F CHEMBL3727638 Ki 20.0 nM
Nc1ncc(-c2cc(C3CN(C4COC4)C3)cc(C3CC3)n2)cc1OC(F)F CHEMBL3732769 Ki 20.0 nM
CC(=O)N1CC2C(C1)C2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3731339 Ki 20.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC(F)C3)n2)cc1OC(F)F CHEMBL3732234 Ki 20.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cc1OC(F)(F)F CHEMBL3731159 Ki 20.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729945 Ki 20.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3F)n2)cc1OC(F)F CHEMBL3728490 Ki 20.2 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)cc(N3CCC3)n2)cc1OC(F)F CHEMBL3729285 Ki 20.4 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)CC3)n2)cc1OC(F)F CHEMBL3733035 Ki 20.7 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1C1CC1 CHEMBL3717907 Ki 21.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 22.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC(F)(F)F)n2)cc1Cl CHEMBL3716363 Ki 22.0 nM
CC(C)n1nc(-c2cnc(N)c(C#N)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3715323 Ki 22.0 nM
CC(C)n1nc(-c2cnc(N)c(C3CC3)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3715738 Ki 22.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(Cl)c3c2)cc1C1CCN(C2COC2)C1 CHEMBL3715836 Ki 22.0 nM
COC1CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3CC4CC3CO4)n2)C1 CHEMBL3728848 Ki 22.0 nM
CC1(F)CCN(c2nc(-c3cnc(N)nc3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3729456 Ki 22.5 nM
Nc1ncc(-c2cc(N3C[C@H]4C[C@@H]3CO4)nc(N3CCCC3)n2)cc1OC(F)F CHEMBL3727400 Ki 22.9 nM
CC(C)(O)Cn1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL4127238 Ki 23.0 nM
C[C@H]1CN(c2nc(-c3cnc(N)nc3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C[C@H]1F CHEMBL3729093 Ki 23.4 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2CC(C)(OC)C2)n1 CHEMBL3732147 Ki 23.5 nM
CC(Oc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cnc1N)c1ccnn1C CHEMBL3731616 Ki 23.8 nM
Cc1nc(Nc2cc(C(F)(F)F)ccn2)cc(C2CCCN(C(=O)c3ccccc3)C2)n1 CHEMBL3393312 Ki 24.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cc1Cl CHEMBL3717180 Ki 24.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC(F)(F)C3)n2)cc1OC(F)F CHEMBL3732917 Ki 24.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cc1Cl CHEMBL3729826 Ki 24.0 nM
Nc1ncc(-c2cc(C3CC3)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F CHEMBL5278185 IC50 24.0 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc([C@H]2[C@@H]3CN(CCOC)C[C@@H]32)n1 CHEMBL3730670 Ki 24.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C34CCC(CC3)C4)n2)cc1OC(F)F CHEMBL3728489 Ki 24.3 nM
COCCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)nc(C2CC2)n1 CHEMBL3732927 Ki 24.4 nM
CC(=O)N1CCC(c2cc(Nc3cc(C#N)ccn3)nc(N3CCC(F)(F)C3)c2)CC1 CHEMBL3393328 Ki 25.0 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)C3)n(C3CCCC3)n2)c1 CHEMBL3629019 Ki 25.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1Cl CHEMBL3718328 Ki 25.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(C#N)c3c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3715335 Ki 25.0 nM
CCc1c[nH]c2ncc(-c3cc(C4CCOC4)n(C4CC(F)(F)C4)n3)cc12 CHEMBL3715928 Ki 25.0 nM
Nc1ncc(-c2cc(N3CC4CC(C3)N4C3COC3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3733157 Ki 25.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(CC4)C3)n2)cn1 CHEMBL3727776 Ki 25.5 nM
Cc1c[nH]c2ncc(-c3cc([C@@H]4CCOC4)n(CC4CC4)n3)cc12 CHEMBL3717099 Ki 26.0 nM
Cc1c[nH]c2ncc(-c3cc([C@H]4CCOC4)n(CC4CC4)n3)cc12 CHEMBL3715643 Ki 26.0 nM
CC(=O)N1CC(c2cc(-c3cnc4[nH]cc(C)c4c3)nn2C(C)C)C1 CHEMBL3718197 Ki 26.0 nM
N#Cc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cnc1N CHEMBL3733147 Ki 26.0 nM
CC(C)(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3717314 Ki 27.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nn1CC1CCC1 CHEMBL3717868 Ki 27.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(Cl)c2)nn1CC1CC1 CHEMBL3718090 Ki 27.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1CN(C2COC2)C1 CHEMBL3715274 Ki 27.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cc1SC(F)(F)F CHEMBL3730744 Ki 27.6 nM
CC(C)n1nc(-c2cnc3[nH]cc(C#N)c3c2)cc1C1CCN(CC(F)(F)F)CC1 CHEMBL3714930 Ki 28.0 nM
Nc1ncc(-c2cc(N3CC4CC4C3)nc(N3CC4CC3C4)n2)cn1 CHEMBL3733221 Ki 28.0 nM
Nc1ncc(-c2cc(C3CC3)cc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F CHEMBL5269484 IC50 28.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C34CCC(CC3)CC4)n2)cc1OC(F)F CHEMBL3733122 Ki 28.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(CC3)COC4)n2)cc1OC(F)F CHEMBL3727772 Ki 28.1 nM
Cc1c[nH]c2ncc(-c3cc(C4CCOC4)n(CC4CC4)n3)cc12 CHEMBL3717079 Ki 29.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)F)c2)nc(N2CCC2)n1 CHEMBL3728114 Ki 29.4 nM
CC(C)(C)c1nc(-c2cnc(N)c(OC(F)F)c2)cc(N2C[C@@H]3C[C@H]2CO3)n1 CHEMBL3733309 Ki 29.8 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(Cl)c2)nn1CC(C)C CHEMBL3715596 Ki 30.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1CCN(C2COC2)C1 CHEMBL3718592 Ki 30.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)cn1 CHEMBL3732804 Ki 30.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3728814 Ki 30.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3728674 Ki 30.0 nM
CC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(C(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3731528 Ki 30.0 nM
Nc1ncc(-c2cc(N3CC4C(C3)C4(Cl)Cl)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3730735 Ki 30.4 nM
N#Cc1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cnc1N CHEMBL3717819 Ki 31.0 nM
Nc1ncc(-c2cc(N3C[C@@H](F)[C@@H](F)C3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3732448 Ki 31.7 nM
CCc1cc([C@H]2[C@@H]3CN(C4COC4)C[C@@H]32)cc(-c2cnc(N)c(OC(F)F)c2)n1 CHEMBL3727916 Ki 31.9 nM
CC(C)Oc1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cnc1N CHEMBL3715800 Ki 32.0 nM
COCCN1C[C@@H]2CN(c3cc(-c4cnc(N)c(OC(F)F)c4)nc(C4CC4)n3)C[C@@H]21 CHEMBL3732033 Ki 32.2 nM
COC1CCN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC3)n2)C1 CHEMBL3731505 Ki 32.4 nM
CC1CCCCN1C1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC(F)(F)C3)n2)C1 CHEMBL3730992 Ki 32.5 nM
CC(=O)N1CCC(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CCC(F)(F)C3)n2)CC1 CHEMBL3393324 Ki 33.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cc1Oc1ccccn1 CHEMBL3732287 Ki 33.2 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(Cl)c2)nn1C(C)C CHEMBL3719016 Ki 34.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1CCN(C2CCC2)CC1 CHEMBL3716510 Ki 34.0 nM
Cc1c[nH]c2ncc(-c3cc(C4CCN(C5COC5)C4)n(C)n3)cc12 CHEMBL3715329 Ki 34.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(Cl)c3c2)cc1C1CN(C2COC2)C1 CHEMBL3719229 Ki 34.0 nM
CC(=O)N1CC(c2cc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)nn2C)C1 CHEMBL3719042 Ki 34.0 nM
CC(C)c1cc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)nn1C1CN(C2COC2)C1 CHEMBL3717680 Ki 34.0 nM
CC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3733171 Ki 34.0 nM
C[C@@]1(F)CCN(c2nc(-c3cnc(N)c(C(F)(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3728711 Ki 34.0 nM
CC1(O)CCN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3730516 Ki 34.8 nM
Cc1nc(Nc2ncc(C)s2)cc(C2CCCN(C(=O)c3ccccc3)C2)n1 CHEMBL3393308 Ki 35.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3717627 Ki 35.0 nM
COc1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cnc1N CHEMBL3719045 Ki 35.0 nM
FC(F)(F)c1c[nH]c2ncc(-c3cc(C4CCOC4)n(C4CCOC4)n3)cc12 CHEMBL3718022 Ki 35.0 nM
Nc1ncc(-c2cc(N3CC[C@H](F)C3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3729006 Ki 36.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@H](F)C3)n2)cc1C(F)(F)F CHEMBL3732771 Ki 36.6 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC(F)C3)n2)cc1OC(F)F CHEMBL3732498 Ki 36.6 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cc1C1CC1 CHEMBL3718982 Ki 37.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC4C3)n2)cn1 CHEMBL3732599 Ki 38.0 nM
Nc1ncc(-c2cc(N3C[C@H]4CCO[C@H]4C3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3732335 Ki 38.3 nM
Nc1ncc(-c2cc(N3CCCOCC3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3730993 Ki 38.6 nM
CC(C)C(O)c1nc(-c2cnc(N)c(OC(F)(F)F)c2)cn1C12CC(C1)C2 CHEMBL5419888 IC50 39.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4(CCCOC4)C3)n2)cc1OC(F)F CHEMBL3731880 Ki 39.2 nM
CC1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)CCN1C1COC1 CHEMBL3729237 Ki 39.3 nM
CC(C)n1nc(-c2cnc(N)c(Cl)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3716424 Ki 40.0 nM
N#CC1(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CC4CC3C4)n2)CCC1 CHEMBL3730911 Ki 40.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@@H](F)[C@@H](F)C3)n2)cn1 CHEMBL3727959 Ki 40.0 nM
Nc1ncc(-c2cc(N3CCCOCC3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3727898 Ki 40.9 nM
FC1(F)CCN(c2nc(Nc3cc(C(F)(F)F)ccn3)cc(C3CCOCC3)n2)C1 CHEMBL3393323 Ki 41.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1C(F)F CHEMBL3714878 Ki 41.0 nM
COCCN1CCC(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)CC1 CHEMBL3728944 Ki 41.1 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 42.0 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)n(C3CCCC3)n2)c1 CHEMBL3629013 Ki 42.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3C[C@@H](F)[C@H](F)C3)n2)cc1OC(F)F CHEMBL3727890 Ki 42.2 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)cc1OCC(F)(F)F CHEMBL3729391 Ki 42.4 nM
Nc1ncc(-c2cc(N3CC4CC3C4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3728429 Ki 43.0 nM
Nc1ncc(-c2cc(N3CCCOCC3)nc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3733144 Ki 43.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1CCN(C)CC1 CHEMBL3717094 Ki 45.0 nM
CCn1cc(-c2cc(-c3cnc(N)c(OC(F)F)c3)nc(C3CC3)n2)cn1 CHEMBL3728074 Ki 46.2 nM
CC(=O)N1CCC(c2cc(-c3cnc4[nH]cc(C)c4c3)nn2C)CC1 CHEMBL3715924 Ki 47.0 nM
Nc1ncc(-c2cc(C3CC3)cc(N3C[C@@H]4C[C@H]3CO4)c2)nc1OC(F)F CHEMBL5278476 IC50 47.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4(CCOC4)C3)n2)cc1OC(F)F CHEMBL3730623 Ki 47.5 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)n(C3CCC(F)(F)C3)n2)c1 CHEMBL3629014 Ki 48.0 nM
N#Cc1ccnc(Nc2cc(C3CN(C4COC4)C3)n(C3CCCC3)n2)c1 CHEMBL3629018 Ki 48.0 nM
Nc1ncc(-c2cn(C34CC(C3)C4)c([C@@H](O)C(F)(F)F)n2)cc1OC(F)(F)F CHEMBL5409049 IC50 48.0 nM
COC1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC3)n2)C1 CHEMBL3732538 Ki 49.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cc1C1CC1 CHEMBL3729476 Ki 50.0 nM
CC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(OC(F)(F)F)c2)nc(N2CC3CC2C3)n1 CHEMBL3731991 Ki 50.0 nM
Nc1ncc(-c2cc(N3C4CCCC3CC4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3730626 Ki 50.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CN4CC(F)(F)F)nc(N3CC4CC3C4)n2)cn1 CHEMBL3730890 Ki 51.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)nc1C(F)(F)F CHEMBL5284496 IC50 53.0 nM
Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3C[C@H]4C[C@@H]3CO4)n2)nc1OC(F)F CHEMBL5273015 IC50 53.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4(CCOCC4)C3)n2)cc1OC(F)F CHEMBL3731490 Ki 53.9 nM
N#Cc1ccnc(Nc2cc(C3CCOC3)n(C3CCCC3)n2)c1 CHEMBL3629172 Ki 54.0 nM
Nc1ncc(-c2cc(N3C[C@H]4C[C@@H]3CO4)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3729580 Ki 54.4 nM
COCCN1CCC(c2cc(-c3cnc(N)c(C(F)(F)F)c3)nn2C(C)C)CC1 CHEMBL3718576 Ki 56.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1CCN(CC#N)CC1 CHEMBL3714843 Ki 56.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(C3CCC3)n2)cc1OC(F)F CHEMBL3728612 Ki 56.0 nM
COc1ccnc(Nc2cc(C3CCCN(C(=O)c4ccccc4)C3)nc(C)n2)c1 CHEMBL3393318 Ki 57.0 nM
FC1(F)CC(n2nc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)cc2C2CCOCC2)C1 CHEMBL3716506 Ki 58.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)(F)F CHEMBL3731591 Ki 58.6 nM
CN1CCC(c2cc(-c3cnc(N)c(Cl)c3)nn2C2CC(F)(F)C2)CC1=O CHEMBL3718909 Ki 60.0 nM
CC1CCCN1c1nc(-c2cnc(N)nc2)cc(C2CCOCC2)n1 CHEMBL3729769 Ki 60.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)cc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3728984 Ki 60.0 nM
Nc1ncc(-c2cc(N3CC[C@@H](F)C3)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3727470 Ki 60.2 nM
Nc1ncc(-c2cc(N3CCCOCC3)nc(C3CC[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3730862 Ki 60.4 nM
Nc1ncc(-c2cc([C@H]3CCCO3)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F CHEMBL5269792 IC50 61.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3727765 Ki 61.2 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(CC(F)(F)F)n2)cc1OC(F)F CHEMBL3727679 Ki 61.5 nM
N#Cc1cc(-c2cc([C@H]3[C@@H]4CN(CC(F)(F)F)C[C@@H]43)n(CC3CC3)n2)cnc1N CHEMBL3717610 Ki 64.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@@H](Oc4ccccc4)C3)n2)cn1 CHEMBL3728547 Ki 65.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)c2c1OCC2 CHEMBL3731962 Ki 65.7 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CCC3)n2)cc1C1CC1 CHEMBL3718303 Ki 66.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4COC[C@@H]43)nc(N3CC4CC3C4)n2)cc1OC(F)(F)F CHEMBL3730382 Ki 66.5 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 67.0 nM
Cn1nc(-c2cnc(N)c(OC(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL4127922 Ki 67.0 nM
Nc1ncc(-c2cc(-c3cnn(C4CC4)c3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3729194 Ki 67.2 nM
Nc1ncc(-c2cc(C3CN(C4CCOC4)C3)cc(C3CC3)n2)cc1OC(F)F CHEMBL3732262 Ki 68.2 nM
CC(C)n1nc(-c2cnc(N)c(OC(F)F)c2)cc1C1CCN(C2COC2)CC1 CHEMBL3718347 Ki 69.0 nM
Nc1ncc(-c2cc(N3C4CCC3CC(O)C4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3728972 Ki 69.0 nM
CCN(CC)c1nc(-c2cnc(N)nc2)cc(N2C[C@@H]3C[C@H]2CO3)n1 CHEMBL3729157 Ki 70.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCC(F)(F)CC3)n2)cn1 CHEMBL3731320 Ki 70.0 nM
Nc1ncc(-c2cc(N3C[C@@H](F)[C@@H](F)C3)nc(N3CC4CC3C4)n2)cn1 CHEMBL3730210 Ki 70.0 nM
CCc1nc(-c2cnc(N)c(OC(F)F)c2)cc([C@H]2[C@@H]3CN(C4COC4)C[C@@H]32)n1 CHEMBL3731181 Ki 70.0 nM
Nc1ncc(-c2cc(N3C[C@H]4COC[C@H]4C3)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3732071 Ki 70.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3CC[C@@H](F)C3)n2)cc1OC(F)F CHEMBL3727405 Ki 73.4 nM
CC(C)n1nc(-c2cnc3c(c2)C(C)(C)CN3)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3715625 Ki 74.0 nM
Cc1c[nH]c2ncc(-c3cc(C4CCOC4)n(C4CCC(F)(F)C4)n3)cc12 CHEMBL3717078 Ki 74.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@@H](F)C3)n2)cn1 CHEMBL3729510 Ki 74.5 nM
CC(=O)N1CC(c2cc(-c3cnc4[nH]cc(C)c4c3)nn2CC2CC2)C1 CHEMBL3716124 Ki 76.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)nc1OC(F)F CHEMBL5277751 IC50 77.0 nM
Nc1ncc(-c2cc(C3CN(C4COC4)C3)cc(N3CC[C@H](F)C3)n2)cc1OC(F)F CHEMBL3728181 Ki 79.3 nM
COC1(C)CN(c2nc(-c3cnc(N)c(OC(F)F)c3)cc(N3C[C@@H]4C[C@H]3CO4)n2)C1 CHEMBL3733194 Ki 80.0 nM
Nc1ncc(-c2cc(N3CC4CC3C4)nc(N3C[C@@H]4C[C@H]3CO4)n2)cn1 CHEMBL3731907 Ki 80.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(N3CC[C@H](F)C3)n2)cc1OC(F)(F)F CHEMBL3730048 Ki 81.8 nM
Cc1c[nH]c2ncc(-c3cc(C4CCOC4)n(C4CC(F)(F)C4)n3)cc12 CHEMBL3717388 Ki 82.0 nM
Cn1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL4126530 Ki 82.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCCC3)n2)cc1C(F)(F)F CHEMBL3716248 Ki 84.0 nM
Cc1ccnc(Nc2cc(C3CCCN(C(=O)c4ccccc4)C3)nc(C)n2)c1 CHEMBL3393310 Ki 85.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCC3)n2)cn1 CHEMBL3729402 Ki 86.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3732755 Ki 86.3 nM
Cc1nc(Nc2cc(C#N)ccn2)cc(C2CCCN(C(=O)c3ccccc3)C2)n1 CHEMBL3393317 Ki 90.0 nM
COCCN1C[C@@H]2[C@H](C1)[C@H]2c1cc(-c2cnc(N)c(Cl)c2)nn1CC1CC1(F)F CHEMBL3715298 Ki 90.0 nM
N#CC1(c2cc(-c3cnc(N)nc3)nc(N3CC4CC3C4)c2)CCC1 CHEMBL3732280 Ki 90.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2COC[C@@H]21 CHEMBL3714788 Ki 91.0 nM
Cc1cc(C2CCN(C3COC3)CC2)cc(Nc2cc(C#N)ccn2)n1 CHEMBL3393338 Ki 93.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4COC[C@@H]43)n(C3CCCC3)n2)cc1Cl CHEMBL3715457 Ki 96.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(F)c3c2)cc1C1CCN(C2COC2)CC1 CHEMBL3719209 Ki 96.0 nM
CC(C)(C#N)c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)c1 CHEMBL3730758 Ki 98.6 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)cc1SC(F)(F)F CHEMBL3732292 Ki 98.6 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 100.0 nM
Cc1c[nH]c2ncc(-c3cc(C4CCOCC4)n(C4CC(F)(F)C4)n3)cc12 CHEMBL3719147 Ki 100.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCC(F)(F)C3)n2)cn1 CHEMBL3730397 Ki 100.0 nM
Nc1ncc(-c2cc(C3C4CCC3CNC4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3730780 Ki 100.0 nM
Nc1ncc(-c2cc(N3CC4CCC(C3)O4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729179 Ki 101.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4COC[C@@H]43)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729601 Ki 106.0 nM
Nc1ncc(-c2cn(C34CC(F)(C3)C4)c([C@@H](O)C(F)(F)F)n2)cc1OC(F)(F)F CHEMBL5408274 IC50 107.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(F)c3c2)cc1C1CCN(C2COC2)C1 CHEMBL3355004 Ki 110.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C(C)(C)O CHEMBL3718563 Ki 110.0 nM
Nc1ncc(-c2cc([C@@H]3[C@@H]4CN(CC(F)(F)F)C[C@@H]43)nc(C3CC3)n2)cc1OC(F)F CHEMBL3729274 Ki 110.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@H]4C[C@@H]3CC4(F)F)n2)cn1 CHEMBL3728224 Ki 110.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729944 Ki 110.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(C3CC(F)C3)n2)cc1OC(F)F CHEMBL3731797 Ki 110.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(C3CCCC3)n2)cc1OC(F)F CHEMBL3733120 Ki 116.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC[C@H](Oc4ccccc4)C3)n2)cn1 CHEMBL3728015 Ki 118.0 nM
CC(C)Oc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCCC3)n2)cnc1N CHEMBL3715823 Ki 120.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(C#N)c3c2)cc1C1CCN(C2COC2)CC1 CHEMBL3718873 Ki 120.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(CC3)CC4)n2)cn1 CHEMBL3730930 Ki 120.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cc1C1CC1(F)F CHEMBL3730117 Ki 122.0 nM
Cc1nnc(C(C)Oc2cc(-c3cc(N4CCC4)nc(C4CC4)n3)cnc2N)s1 CHEMBL3729804 Ki 125.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(F)c3c2)cc1[C@H]1[C@@H]2COC[C@@H]21 CHEMBL3716659 Ki 130.0 nM
CC(C)n1nc(-c2cnc(N)c(OC(C)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3717401 Ki 130.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@H]4CCC(F)(F)[C@H]4C3)n2)cn1 CHEMBL3730876 Ki 130.0 nM
Nc1ncc(-c2cc(N3C4CCC3COC4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3728787 Ki 130.0 nM
Nc1ncc(-c2cc(N3CC4CC3CN4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729658 Ki 130.0 nM
CC1CN(c2cc(-c3cnc(N)c(OC(F)F)c3)nc(N3CCC3)n2)CCO1 CHEMBL3727987 Ki 131.0 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)n(CC3CCC3)n2)c1 CHEMBL3629017 Ki 133.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@H]4CCO[C@H]4C3)n2)cc1C(F)(F)F CHEMBL3729749 Ki 137.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 140.0 nM
COc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C(C)C)n2)cnc1N CHEMBL3715637 Ki 140.0 nM
CN1CCC(c2cc(-c3cnc4[nH]cc(C(F)(F)F)c4c3)nn2C2CC(F)(F)C2)CC1=O CHEMBL3718757 Ki 140.0 nM
CC(C)n1nc(-c2cnc(N)c(OC(F)(F)F)c2)cc1C(C)(C)C#N CHEMBL3716965 Ki 140.0 nM
CC(C)n1nc(-c2cnc(N)c(OC(F)F)c2)cc1C(C)(C)O CHEMBL3715583 Ki 140.0 nM
CC1(O)CC2CCC(C1)N2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3732859 Ki 140.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)nc(N3CCC3)n2)cc1OC(F)F CHEMBL3729374 Ki 140.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)nc(C3CC(F)(F)C3)n2)cc1OC(F)F CHEMBL3729710 Ki 143.0 nM
CC(C)n1nc(Nc2cc(C(F)(F)F)ccn2)cc1C1CCNCC1 CHEMBL3629009 Ki 145.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1CCN(C2COC2)CC1 CHEMBL3719126 Ki 150.0 nM
Nc1ncc(-c2cc(N3C[C@H]4C[C@@H]3CO4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3727559 Ki 150.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cc1Cc1ccccn1 CHEMBL3733079 Ki 156.0 nM
CC(C)n1nc(Nc2cc(C#N)ccn2)cc1C1CCNCC1 CHEMBL3629010 Ki 160.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1(O)CCCC1 CHEMBL3717336 Ki 160.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4(CCC4(F)F)C3)n2)cn1 CHEMBL3727666 Ki 160.0 nM
Nc1ncc(-c2cc(C3CC4CCC(C3)N4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3731993 Ki 160.0 nM
Nc1ncc(-c2cc(C3CN(C4COC4)C3)cc(N3CCC3)n2)cc1OC(F)F CHEMBL3732199 Ki 161.1 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC3)n2)cc1C(F)(F)F CHEMBL3729634 Ki 164.0 nM
CC(=O)N1CCC(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CC(F)(F)C3)n2)CC1 CHEMBL3393325 Ki 166.0 nM
Cc1cnc(C(C)Oc2cc(-c3cc(N4CCC4)nc(C4CC4)n3)cnc2N)s1 CHEMBL3729324 Ki 169.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 170.0 nM
N#Cc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCCC3)n2)cnc1N CHEMBL3717151 Ki 170.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC4(CC3)CC(F)C4)n2)cn1 CHEMBL3729700 Ki 170.0 nM
Nc1ncc(-c2cc(C3CC4CCC(C3)N4CC(F)(F)F)nc(N3CC4CC3C4)n2)cn1 CHEMBL3730345 Ki 170.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CS4(=O)=O)nc(N3CC4CC3C4)n2)cn1 CHEMBL3728816 Ki 170.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(CC(F)(F)F)C[C@@H]43)n(C3COC3)n2)cc1Cl CHEMBL3717817 Ki 180.0 nM
CS(=O)(=O)c1cc(-c2cc([C@H]3[C@@H]4CN(C5CCC5)C[C@@H]43)n(C3CCCC3)n2)cnc1N CHEMBL3718859 Ki 180.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@H]4CCO[C@H]4C3)n2)cc1OC(F)(F)F CHEMBL3731318 Ki 180.0 nM
Nc1ncc(-c2cc(-n3cccn3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3728271 Ki 185.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 190.0 nM
CCc1ccnc(Nc2cc(C3CCCN(C(=O)c4ccccc4)C3)nc(C)n2)c1 CHEMBL3393313 Ki 195.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3C[C@@H]4CC(F)(F)C[C@@H]4C3)n2)cn1 CHEMBL3731512 Ki 200.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(CC(F)(F)F)C[C@@H]43)nc(N3CC4CC3C4)n2)cc1OC(F)F CHEMBL3727502 Ki 200.0 nM
Nc1cnc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)cn1 CHEMBL5281886 IC50 201.0 nM
Nc1ncc(-c2cc(N3CC4CCC(C3)N4C3COC3)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729398 Ki 210.0 nM
Nc1ncc(-c2nc(N3CC4CC3C4)nc(N3C[C@@H]4C[C@H]3CO4)c2F)cn1 CHEMBL3727421 Ki 210.0 nM
N#CC1(c2cc(-c3cnc(N)nc3)nc(N3CC4CC3C4)n2)CCC1 CHEMBL3729565 Ki 210.0 nM
CC(Oc1cc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cnc1N)c1nccn1C CHEMBL3727525 Ki 210.0 nM
Nc1ncc(-c2cc(C3CN(C4COC4)C3)nc(C3CC3)n2)cc1OC(F)F CHEMBL3730552 Ki 212.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(C(F)(F)F)CC3)n2)cn1 CHEMBL3730820 Ki 220.0 nM
CCN1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3729884 Ki 220.0 nM
CC(C)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)nc2)nc(N2CC3CC2C3)n1 CHEMBL3732153 Ki 220.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)CC3)n2)cn1 CHEMBL3728083 Ki 220.0 nM
Cc1c[nH]c2ncc(-c3cc(C4CCN(C)C(=O)C4)n(C4CC(F)(F)C4)n3)cc12 CHEMBL3715246 Ki 250.0 nM
COc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCCC3)n2)cnc1N CHEMBL3718839 Ki 260.0 nM
CC(C)Oc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C(C)C)n2)cnc1N CHEMBL3716934 Ki 260.0 nM
Nc1ncc(-c2cn(C34CC(N5CCOCC5)(C3)C4)c(C3CC3)n2)cc1OC(F)(F)F CHEMBL5436727 IC50 262.0 nM
CC(C)n1nc(-c2cnc(N)c3cn[nH]c23)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3355006 Ki 270.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCCC3)n2)cc1Cl CHEMBL3716658 Ki 270.0 nM
Nc1ncc(-c2cc(N3C4CCCC3CCC4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3728686 Ki 270.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC(F)(F)C3)n2)cn1 CHEMBL3729575 Ki 270.0 nM
CC(=O)N1C2CCC1CC(c1cc(-c3cnc(N)nc3)nc(N3CC4CC3C4)n1)C2 CHEMBL3733093 Ki 280.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CN4C3COC3)nc(N3CC4CC3C4)n2)cn1 CHEMBL3730700 Ki 290.0 nM
CS(=O)(=O)c1cc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(C3CCCC3)n2)cnc1N CHEMBL3718282 Ki 300.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3(C(F)(F)F)CC=NN3)n2)cc1OC(F)F CHEMBL3732823 Ki 302.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(C#N)c3c2)cc1C1CN(C2COC2)C1 CHEMBL3715234 Ki 310.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)cc(N3CC4CC3C4)n2)cn1 CHEMBL3730592 Ki 320.0 nM
CC1CN(c2cc(-c3cnc(N)nc3)nc(N3CC4CC3C4)n2)CC(C)O1 CHEMBL3728336 Ki 320.0 nM
Nc1ncc(-c2cc(N3CC(N4CCOCC4)C3)cc(C3CC3)n2)cc1OC(F)F CHEMBL3733359 Ki 321.0 nM
Nc1ncc(-c2cc(N3CC(N4CCCCC4)C3)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F CHEMBL3730307 Ki 321.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 330.0 nM
Nc1ncc(-c2cc(C3CCOC3)n(C3CCC(F)(F)C3)n2)cc1Cl CHEMBL3715988 Ki 350.0 nM
CC(C)n1nc(-c2cnc(N)c(C3CC3)c2)cc1C1CCN(C2COC2)CC1 CHEMBL3715893 Ki 360.0 nM
Nc1ncc(-c2cn(C34CC(N5CCOCC5)(C3)C4)c(C3CC3)n2)cc1C(F)(F)F CHEMBL5422141 IC50 366.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 370.0 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)n(C3CCOC3)n2)c1 CHEMBL3629015 Ki 378.0 nM
CCOc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C(C)C)n2)cnc1N CHEMBL3715127 Ki 390.0 nM
Cc1ccc(Nc2cc(C3CCCN(C(=O)c4ccccc4)C3)nc(C)n2)nc1 CHEMBL3393309 Ki 401.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC3)n2)cn1 CHEMBL3727680 Ki 410.0 nM
Nc1ncc(-c2cc(C3C4CCC3CN(C3COC3)C4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3732904 Ki 410.0 nM
CC(C)c1nc(-c2cnc(N)c(OC(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 CHEMBL5412914 IC50 424.0 nM
Cc1nccn1-c1cc(-c2cnc(N)c(OC(F)F)c2)nc(C2CC2)n1 CHEMBL3730768 Ki 428.0 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(CC(F)(F)F)C[C@@H]43)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729714 Ki 430.0 nM
CC(=O)N1CCC(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CCOCC3)n2)CC1 CHEMBL3393326 Ki 431.0 nM
Nc1ncc(-c2cc(C3CCOCC3)n(C3CC(F)(F)C3)n2)cc1Cl CHEMBL3718307 Ki 460.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1CN(C)C1 CHEMBL3715020 Ki 470.0 nM
CC1(C)CN(c2cc(-c3cnc(N)nc3)nc(N3CC4CC3C4)n2)CCO1 CHEMBL3728082 Ki 480.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)cc(N3CC(F)C3)n2)cc1Cl CHEMBL3731162 Ki 490.0 nM
Nc1ncc(-c2cn(C34CC(N5CCOCC5)(C3)C4)c(CC3CC3)n2)cc1C(F)(F)F CHEMBL5405288 IC50 494.0 nM
CC(C)c1nc(-c2cnc(N)c(C(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 CHEMBL5397873 IC50 504.0 nM
CC(=O)N1CC2C(C1)C2c1cc(-c2cnc(N)nc2)nc(C2CC2)n1 CHEMBL3730342 Ki 530.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCCCC3)n2)cn1 CHEMBL3728845 Ki 540.0 nM
Nc1ncc(-c2cc(C3CCOC3)n(C3CC(F)(F)C3)n2)cc1Cl CHEMBL3718210 Ki 550.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 560.0 nM
N#Cc1ccnc(Nc2nc(C3CC3)c(C3CCN(C4COC4)CC3)s2)c1 CHEMBL3629173 Ki 569.0 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)n(C3CCOCC3)n2)c1 CHEMBL3629016 Ki 593.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCC(F)(F)C3)n2)cc1OCC1CC1 CHEMBL3716149 Ki 640.0 nM
CC(C)n1nc(-c2cnc3[nH]cc(F)c3c2)cc1C1CN(C2COC2)C1 CHEMBL3715702 Ki 640.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC(F)C3)n2)cn1 CHEMBL3727745 Ki 650.0 nM
CC(C)Cc1nc(-c2cnc(N)c(C(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 CHEMBL5423382 IC50 655.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 670.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 670.0 nM
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(C3CC3)n2)cn1 CHEMBL3729350 Ki 680.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)cc(N3CC(F)C3)n2)cc1C(F)(F)F CHEMBL3728348 Ki 690.0 nM
Cc1nc(Nc2ccc(C(F)(F)F)cn2)cc(C2CCCN(C(=O)c3ccccc3)C2)n1 CHEMBL3393311 Ki 691.0 nM
Nc1ncc(-c2cc(N3CCOCC3)nc(N3CCOCC3)n2)cn1 CHEMBL2017971 Ki 710.0 nM
Cc1nc(Nc2cc(C(F)(F)F)ccn2)cc(C2CCCNC2)n1 CHEMBL3393319 Ki 725.0 nM
COC1CN(c2cc(C3CCN(C4COC4)CC3)cc(-c3cnc(N)c(C(F)(F)F)c3)n2)C1 CHEMBL3732680 Ki 740.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C(C)(C)C#N CHEMBL3715147 Ki 780.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCOC3)n2)cc1C(F)(F)F CHEMBL3718065 Ki 810.0 nM
Nc1ncc(-c2cc(C34CC(CN3)C4)nc(N3CC4CC3C4)n2)cn1 CHEMBL3729997 Ki 810.0 nM
Nc1ncc(-c2cc(N3C4CC5CC(C4)CC3C5)nc(N3CC4CC3C4)n2)cn1 CHEMBL3731670 Ki 830.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 840.0 nM
CC(C)c1nc(-c2cnc(N)c(C(F)(F)F)c2)cn1C12CC(C1)C2 CHEMBL5394131 IC50 850.0 nM
CC(C)Oc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCC(F)(F)C3)n2)cnc1N CHEMBL3715398 Ki 910.0 nM
CC(C)n1nc(-c2cnc(N)c(C#N)c2)cc1C1CCN(C2COC2)CC1 CHEMBL3716692 Ki 940.0 nM
Cc1nc(Nc2ccccn2)cc(C2CCCN(C(=O)c3ccccc3)C2)n1 CHEMBL3393316 Ki 942.0 nM
CC(C)n1nc(-c2cnc(N)c3cn[nH]c23)cc1[C@H]1[C@@H]2CN(CC(F)(F)F)C[C@@H]21 CHEMBL3716822 Ki 960.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCOC3)n2)cc1Cl CHEMBL3715142 Ki 980.0 nM
Nc1ncc(-c2cc(N3CC4CC3C4)cc(N3CC4CC3C4)n2)cn1 CHEMBL3732855 Ki 980.0 nM
CCOc1cc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCC(F)(F)C3)n2)cnc1N CHEMBL3717925 Ki 990.0 nM
Nc1ncc(-c2cc(C3CCN(C4COC4)CC3)n(C3CCC(F)(F)C3)n2)cc1Cl CHEMBL3716915 Ki 1000.0 nM
CC(C)n1nc(-c2cnc(N)c(Cl)c2)cc1C1CCN(C2COC2)CC1 CHEMBL3718750 Ki 1000.0 nM
CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1C1C2CC1CN(C1COC1)C2 CHEMBL3715477 Ki 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM