CN1CCC(O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2CCO3)C1=O CHEMBL3696534 Ki 0.04 nM
COc1ccc2c(-c3cccc(C#C[C@]4(O)CCN(C)C4=O)c3)nc(C(N)=O)n2c1 CHEMBL4205698 Ki 0.05 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2CCO3)C1=O CHEMBL3696579 Ki 0.055 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3cc4ccccc4c(C(N)=O)n3)c2)C1=O CHEMBL4215425 Ki 0.07 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3ccc(N)c(C(N)=O)n3)c2)C1=O CHEMBL4216289 Ki 0.07 nM
CN1CC[C@@](O)(C#Cc2ccnc(-n3nc(C(N)=O)c4ccccc43)c2)C1=O CHEMBL4211046 Ki 0.08 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c([C@H](O)c4ccnn4C)n2C2CC3C2)no1 CHEMBL4115488 Ki 0.1 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c([C@@H](O)c4ccnn4C)n2C2CC3C2)no1 CHEMBL3934782 Ki 0.1 nM
C[C@H]1COc2ccc(C#C[C@]3(O)CCNC3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700218 Ki 0.1 nM
C[C@@H]1COc2ccc(C#C[C@]3(O)CCNC3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700225 Ki 0.1 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3696555 Ki 0.12 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC3(O)CCCC3)cc1-2 CHEMBL3696576 Ki 0.12 nM
COc1cnc2c(c1)c(C(N)=O)nn2-c1cccc(C#C[C@]2(O)CCN(C)C2=O)c1 CHEMBL4204233 Ki 0.13 nM
Cn1c(C(N)=O)nc2c1C1CC(C1)c1cc(F)c(C#C[C@@](C)(O)c3ncccn3)cc1-2 CHEMBL3696586 Ki 0.16 nM
CCOc1nc2ccc(C#C[C@@](C)(O)c3ncc(C)o3)cc2n1-c1ccnc(N)n1 CHEMBL4524153 Ki 0.16 nM
CN1CC[C@@](O)(C#Cc2ccnc(-n3nc(C(N)=O)c4cc(F)ccc43)c2)C1=O CHEMBL4211551 Ki 0.17 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3nc(C(N)=O)n4ccccc34)c2)C1=O CHEMBL4217407 Ki 0.18 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2CCO3)no1 CHEMBL4112609 Ki 0.2 nM
NC(=O)c1nc2c(s1)CCOc1cc(F)c(C#CC3(O)CCCC3)cc1-2 CHEMBL3692395 Ki 0.2 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)c2[nH]c(C(N)=O)nc2-3)no1 CHEMBL4113253 Ki 0.2 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#CC3(O)CCC3)cc1-2 CHEMBL3696652 Ki 0.2 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(Cc4ccnn4C)n2C2CC3C2)no1 CHEMBL4110869 Ki 0.2 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OCC(F)(F)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3700272 Ki 0.2 nM
CN1CC[C@@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cccnc43)c2)C1=O CHEMBL4209095 Ki 0.2 nM
CN1CC[C@@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4ccccc43)c2)C1=O CHEMBL4212052 Ki 0.23 nM
COc1cc(C(N)=O)nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c1 CHEMBL4211840 Ki 0.23 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)C1=O CHEMBL3696566 Ki 0.24 nM
CN1CC[C@@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cc(F)ccc43)c2)C1=O CHEMBL4208337 Ki 0.27 nM
Cc1cnc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)o1 CHEMBL3957252 Ki 0.29 nM
Cc1cnc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)o1 CHEMBL4109262 Ki 0.29 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)no1 CHEMBL4098056 Ki 0.3 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3692450 Ki 0.3 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)no1 CHEMBL4113471 Ki 0.3 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)c1c-2nc(C(N)=O)n1C(F)F CHEMBL3696699 Ki 0.3 nM
C[C@@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3696721 Ki 0.3 nM
C[C@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3696722 Ki 0.3 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)F)c2CCO3)C1=O CHEMBL3700328 Ki 0.3 nM
C[C@](O)(C#Cc1ccc2ncc(-c3nc(N)ncc3Cl)n2c1)c1nccs1 CHEMBL4285011 Ki 0.3 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C2CC2)no1 CHEMBL4111969 Ki 0.31 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OC[C@@H](N(C)C)c2sc(C(N)=O)nc2-3)no1 CHEMBL3696558 Ki 0.33 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OC[C@H](N(C)C)c2sc(C(N)=O)nc2-3)no1 CHEMBL3696560 Ki 0.33 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C(F)(F)CO3)C1=O CHEMBL3700298 Ki 0.33 nM
CN1CC[C@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C(F)(F)CO3)C1=O CHEMBL3700299 Ki 0.33 nM
NC(=O)c1cc2n(n1)-c1cc(C#C[C@]3(O)CCNC3=O)ccc1OCC2(F)F CHEMBL3700232 Ki 0.33 nM
C[C@@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-n2nc(C(N)=O)c(C(F)(F)F)c21 CHEMBL3700221 Ki 0.39 nM
C[C@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-n2nc(C(N)=O)c(C(F)(F)F)c21 CHEMBL3700227 Ki 0.39 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NCC#N CHEMBL3692439 Ki 0.4 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1nc(-c2cccnc2)n[nH]1 CHEMBL3692522 Ki 0.4 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC3(O)CCC3)cc1-2 CHEMBL3696659 Ki 0.4 nM
Cc1cc([C@@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@H](C)CO3)no1 CHEMBL3700192 Ki 0.4 nM
Cc1cc([C@@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@H](C)CO3)no1 CHEMBL3700197 Ki 0.4 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](O)CO3)C1=O CHEMBL3700276 Ki 0.4 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](O)CO3)C1=O CHEMBL3700277 Ki 0.4 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(Cl)c2C(F)(F)CO3)C1=O CHEMBL3700329 Ki 0.4 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2cc(C(N)=O)nc2-3)no1 CHEMBL4073390 Ki 0.4 nM
CC(O)(C#Cc1ccc2c(c1)N(c1nc(N)ncc1Cl)CC2)c1nccs1 CHEMBL3187788 Ki 0.4 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3cccc(C(N)=O)n3)c2)C1=O CHEMBL4211560 Ki 0.42 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(F)(F)F)n2C2CC3C2)no1 CHEMBL4113023 Ki 0.5 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C(C)(C)O CHEMBL3696553 Ki 0.5 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)c2c-3nc(C(N)=O)n2C)no1 CHEMBL4109556 Ki 0.5 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)C2CC(C2)c2c-3nc(C(N)=O)n2C)C1=O CHEMBL3696671 Ki 0.5 nM
CN1CC[C@](O)(C#Cc2cc3c(cc2F)C2CC(C2)c2c-3nc(C(N)=O)n2C)C1=O CHEMBL3696672 Ki 0.5 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3696705 Ki 0.5 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C2(CCC2)CO3)C1=O CHEMBL3700327 Ki 0.5 nM
CN1CCC(O)(C#Cc2cc3c(cc2F)OCCc2sc(C(N)=O)nc2-3)C1=O CHEMBL3696533 Ki 0.53 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCC3)c(F)cc1C1CC2C1 CHEMBL3696655 Ki 0.53 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(CNC3COC3)n1CCO2 CHEMBL3700314 Ki 0.54 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](O)(CF)CO3)C1=O CHEMBL3696732 Ki 0.56 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](O)(CF)CO3)C1=O CHEMBL3639388 Ki 0.56 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@H](O)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3700283 Ki 0.58 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@@H](O)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3700284 Ki 0.58 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](F)(CF)CO3)C1=O CHEMBL3700303 Ki 0.58 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](F)(CF)CO3)C1=O CHEMBL3700304 Ki 0.58 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(-c4cnn(CC(C)(C)O)c4)n2C2CC3C2)no1 CHEMBL4108562 Ki 0.59 nM
COc1cc(C(N)=O)nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)n1 CHEMBL4214032 Ki 0.59 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCc2sc(C(N)=O)nc2-3)no1 CHEMBL4111063 Ki 0.6 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3692559 Ki 0.61 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)c1[nH]c(C(N)=O)nc1-2 CHEMBL3696524 Ki 0.68 nM
C[C@H]1COc2ccc(C#C[C@@](C)(O)c3ncccn3)cc2-c2nc(C(N)=O)sc21 CHEMBL3700212 Ki 0.68 nM
C[C@@H]1COc2ccc(C#C[C@@](C)(O)c3ncccn3)cc2-c2nc(C(N)=O)sc21 CHEMBL3700224 Ki 0.684 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C)no1 CHEMBL4112414 Ki 0.7 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC3(O)CCC3)cc1-2 CHEMBL3696653 Ki 0.7 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](C)(O)CO3)C1=O CHEMBL3700274 Ki 0.7 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](C)(O)CO3)C1=O CHEMBL3700275 Ki 0.7 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2-c2cnn(CC(C)(C)O)c2)no1 CHEMBL4112497 Ki 0.71 nM
Cc1nc2ccccc2n1Cc1c(C(N)=O)nc2n1CCOc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3696703 Ki 0.71 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(F)(F)F)n2CCO3)C1=O CHEMBL3696706 Ki 0.72 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC4CCOCC4)n2CCO3)C1=O CHEMBL3696708 Ki 0.73 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](C)CO3)no1 CHEMBL3700200 Ki 0.73 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](C)CO3)no1 CHEMBL3700207 Ki 0.73 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@H](F)COc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3700213 Ki 0.76 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@@H](F)COc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3700216 Ki 0.76 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1-c1nc(-c2cccnc2)n[nH]1 CHEMBL3692557 Ki 0.77 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@@H](C)COc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3700231 Ki 0.77 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@H](C)COc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3700233 Ki 0.77 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(F)F)n2C2CC3C2)C1=O CHEMBL3700288 Ki 0.78 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OCC(F)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3700201 Ki 0.8 nM
[2H]C([2H])(O)c1ccc(C)c(Nc2nccc(-c3cc(C#N)c4c(c3)[C@@](C)(CO)CN4)n2)c1 CHEMBL4206684 IC50 0.8 nM
COC[C@@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700199 Ki 0.81 nM
COC[C@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700206 Ki 0.81 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(Cl)c2CCO3)C1=O CHEMBL3700302 Ki 0.82 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C2(CC2)CO3)C1=O CHEMBL3696731 Ki 0.83 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#C[C@@](C)(O)c3ccccn3)cc1-2 CHEMBL3696548 Ki 0.84 nM
C[C@@H]1COc2ccc(C#C[C@]3(O)CCCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700179 Ki 0.86 nM
C[C@H]1COc2ccc(C#C[C@]3(O)CCCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700184 Ki 0.86 nM
CN1CC[C@@](O)(C#Cc2ccnc(-n3nc(C(N)=O)c4c3CCCC4)c2)C1=O CHEMBL4216004 Ki 0.86 nM
Cc1nc2ccccc2n1Cc1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3696689 Ki 0.87 nM
CN1C(=O)[C@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cccnc43)c2)[C@H]2C[C@H]21 CHEMBL5405484 Ki 0.88 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCc4cccnc43)c(F)cc1OCC2 CHEMBL3692537 Ki 0.9 nM
CO[C@@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700262 Ki 0.9 nM
CO[C@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700263 Ki 0.9 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C2CC3C2)C1=O CHEMBL3700254 Ki 0.94 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2CCO3)C1=O CHEMBL3700297 Ki 0.94 nM
CN1CC[C@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2CCO3)C1=O CHEMBL3639991 Ki 0.94 nM
CC1COc2ccc(C#C[C@@](C)(O)c3ccccn3)cc2-c2nc(C(N)=O)sc21 CHEMBL3700300 Ki 0.94 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](CO)CO3)C1=O CHEMBL3700260 Ki 0.97 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](CO)CO3)C1=O CHEMBL3700261 Ki 0.97 nM
NC(=O)c1nc2c(s1)C(F)(F)COc1ccc(C#C[C@]3(O)CCNC3=O)cc1-2 CHEMBL3700273 Ki 0.97 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2[C@H](O)c2ccnn2C)C1=O CHEMBL3696617 Ki 0.99 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2[C@@H](O)c2ccnn2C)C1=O CHEMBL3696620 Ki 0.99 nM
CN1CC[C@](O)(C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2[C@H](O)c2ccnn2C)C1=O CHEMBL3696626 Ki 0.99 nM
CN1CC[C@](O)(C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2[C@@H](O)c2ccnn2C)C1=O CHEMBL3696627 Ki 0.99 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)no1 CHEMBL4115120 Ki 1.0 nM
Cc1cc([C@@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2C2CC2)no1 CHEMBL3915188 Ki 1.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3692453 Ki 1.0 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2C(=O)NCC#N)no1 CHEMBL4108462 Ki 1.0 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)OCCc2sc(C(N)=O)nc2-3)no1 CHEMBL4115232 Ki 1.0 nM
CN1CCC(O)(C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)C1=O CHEMBL3696535 Ki 1.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1c[nH]cn1 CHEMBL3696592 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@H](F)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3696717 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@@](C)(O)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3696718 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@@H](F)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3696719 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@](C)(O)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3696720 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@]2(CO3)CC2(F)F)C1=O CHEMBL4112627 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@]2(CO3)CC2(F)F)C1=O CHEMBL3947514 Ki 1.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NCc4cccnc4)n2CCO3)no1 CHEMBL4112134 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)n(C)c2C2CC3C2)C1=O CHEMBL3700289 Ki 1.0 nM
CN1CC[C@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)n(C)c2C2CC3C2)C1=O CHEMBL3700290 Ki 1.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(CO)c2CCO3)C1=O CHEMBL3700330 Ki 1.0 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#CC3(O)CCCC3)cc1-2 CHEMBL3696556 Ki 1.07 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC4CCOCC4)n2C2CC3C2)no1 CHEMBL4111523 Ki 1.1 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(Cn4c(C)nc5ccccc54)n2CCO3)no1 CHEMBL4110441 Ki 1.1 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(COc4ccccc4Cl)n2C2CC3C2)C1=O CHEMBL3696709 Ki 1.1 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C(F)(F)CO3)no1 CHEMBL4109622 Ki 1.1 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(O)c3ccccn3)cc1-2 CHEMBL3692530 Ki 1.2 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(CC4(C)COC4)n2C2CC3C2)no1 CHEMBL4109516 Ki 1.2 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(Cc4ccnn4C)n2C2CC3C2)no1 CHEMBL4107044 Ki 1.2 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)C1=O CHEMBL3696599 Ki 1.2 nM
CC(C)NC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3696707 Ki 1.2 nM
C[C@@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-n2nc(C(N)=O)cc21 CHEMBL3700180 Ki 1.2 nM
C[C@H]1COc2ccc(C#C[C@]3(O)CCN(C)C3=O)cc2-n2nc(C(N)=O)cc21 CHEMBL3700185 Ki 1.2 nM
CNC(=O)c1c(C(N)=O)nn2c1CCOc1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3700193 Ki 1.2 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@@H](F)COc1ccc(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3700214 Ki 1.2 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@H](F)COc1ccc(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3700217 Ki 1.2 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OCC(C)(O)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3700219 Ki 1.2 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@H](C)COc1ccc(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3700220 Ki 1.2 nM
CNC(=O)c1c(C(N)=O)nn2c1[C@@H](C)COc1ccc(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3700226 Ki 1.2 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@](C)(F)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3700278 Ki 1.2 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OC[C@@](C)(F)c2sc(C(N)=O)nc2-3)C1=O CHEMBL3700279 Ki 1.2 nM
C[C@](O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1CCO2)c1ncns1 CHEMBL3700313 Ki 1.2 nM
Cc1ccc(C#N)cc1Nc1ncc(F)c(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 CHEMBL4211563 IC50 1.2 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2-c2cnn(CC(C)(C)O)c2)no1 CHEMBL4112468 Ki 1.27 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(F)(F)F)n2C2CC3C2)no1 CHEMBL4106919 Ki 1.3 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1-c1nc(C2CC2)n[nH]1 CHEMBL3696552 Ki 1.3 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C)no1 CHEMBL4115109 Ki 1.3 nM
C#Cc1cc(C(C)(O)C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)no1 CHEMBL3696593 Ki 1.3 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(Cc4ccccc4Cl)n2C2CC3C2)C1=O CHEMBL3696608 Ki 1.3 nM
Cn1nccc1Cc1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@@](C)(O)c3ncccn3)cc1-2 CHEMBL3696669 Ki 1.3 nM
Cc1cc(CCN2CCOCC2)c(C#N)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 CHEMBL4216964 IC50 1.3 nM
C[C@]1(CO)CNc2c(C#N)cc(-c3ccnc(Nc4cc(C#N)ccc4CO)n3)cc21 CHEMBL4218937 IC50 1.3 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3cncc(C(N)=O)n3)c2)C1=O CHEMBL4217923 Ki 1.3 nM
CNC(=O)c1c(C(N)=O)nn2c1CCOc1ccc(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3700215 Ki 1.4 nM
CC(C)Oc1ccc(CO)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 CHEMBL4202865 IC50 1.4 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C1CC2C1)CF CHEMBL3692525 Ki 1.5 nM
Cn1nccc1C(O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692534 Ki 1.5 nM
NC(=O)c1nc2n(c1C1CC1)C1CC(C1)c1cc(F)c(C#C[C@]3(O)CCNC3=O)cc1-2 CHEMBL3639955 Ki 1.5 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](F)(CO)CO3)C1=O CHEMBL3700205 Ki 1.5 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1nccs1 CHEMBL3692496 Ki 1.5 nM
Cc1cc(C(C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C(F)(F)F)no1 CHEMBL3692554 Ki 1.7 nM
CN1CCC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C(F)(F)CO3)C1=O CHEMBL3700190 Ki 1.7 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C[C@H](C(C)(C)O)O3)no1 CHEMBL4108813 Ki 1.7 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C[C@@H](C(C)(C)O)O3)no1 CHEMBL3900931 Ki 1.7 nM
CC(C)[C@]1(O)COc2cc(F)c(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700286 Ki 1.7 nM
CC(C)[C@@]1(O)COc2cc(F)c(C#C[C@]3(O)CCN(C)C3=O)cc2-c2nc(C(N)=O)sc21 CHEMBL3700287 Ki 1.7 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)n(C)c2C2CC3C2)no1 CHEMBL4110898 Ki 1.8 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C2CC3C2)no1 CHEMBL4108385 Ki 1.8 nM
Cc1cc(F)c(C#N)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 CHEMBL4216017 IC50 1.8 nM
CNC(=O)c1ccc(C)c(Nc2nccc(-c3cc(C#N)c4c(c3)[C@@](C)(CO)CN4)n2)c1 CHEMBL4218285 IC50 1.8 nM
C[C@@](O)(C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2)c1ccccn1 CHEMBL3696540 Ki 1.9 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2C2CC2)C1=O CHEMBL3696704 Ki 1.9 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@H](F)CO3)C1=O CHEMBL3700167 Ki 1.9 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@H](F)CO3)C1=O CHEMBL3700174 Ki 1.9 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(CN3CCC(C#N)C3)n1CCO2 CHEMBL3700319 Ki 1.9 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cc(CO)on1 CHEMBL3692387 Ki 2.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#C[C@@](C)(O)c3noc(C)n3)cc1-2 CHEMBL3692452 Ki 2.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(CN4CCOCC4)n2CCO3)no1 CHEMBL4107156 Ki 2.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(O)CF)cc1-2 CHEMBL3692463 Ki 2.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(O)CO)cc1-2 CHEMBL3692475 Ki 2.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1nc(C2CC2)n[nH]1 CHEMBL3692478 Ki 2.0 nM
CN1CCCC(O)(C#Cc2cc3c(cc2F)OCCc2sc(C(N)=O)nc2-3)C1=O CHEMBL3692492 Ki 2.0 nM
Cn1nccc1Cn1c(C(N)=O)nc2c1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696681 Ki 2.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692396 Ki 2.0 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3ccnc(C(N)=O)n3)c2)C1=O CHEMBL4210461 Ki 2.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCc1sc(C(N)=O)nc1-2)c1ncn[nH]1 CHEMBL3692532 Ki 2.1 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@@](C)(O)c3noc(C)n3)cc1-2 CHEMBL3692561 Ki 2.1 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CNC(=O)C1CC1 CHEMBL3696544 Ki 2.1 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1Cc1ccccc1Cl CHEMBL3696554 Ki 2.1 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@@](C)(O)c3ccccn3)cc1-2 CHEMBL3696588 Ki 2.1 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](F)(CO)CO3)C1=O CHEMBL3700178 Ki 2.1 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)(F)F)c2CCO3)C1=O CHEMBL3700183 Ki 2.1 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C4CC4)n2CCO3)no1 CHEMBL4111424 Ki 2.2 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696565 Ki 2.2 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#CC3(O)CCC3)cc1-2 CHEMBL3696661 Ki 2.2 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)n(Cc4nn(C)c5ccccc45)c2C2CC3C2)C1=O CHEMBL3700291 Ki 2.2 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)(F)F)c2[C@@H](F)CO3)C1=O CHEMBL3700204 Ki 2.3 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)(F)F)c2[C@H](F)CO3)C1=O CHEMBL3700210 Ki 2.3 nM
Cc1cc(F)c(CO)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 CHEMBL4207209 IC50 2.3 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(-c3nc(C4CC4)n[nH]3)n1CCO2 CHEMBL3692539 Ki 2.4 nM
Cn1nccc1Cc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696551 Ki 2.4 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2cc(C(N)=O)nc2-3)on1 CHEMBL4115024 Ki 2.4 nM
Cn1c(C(N)=O)nc2c1C1CC(C1)c1ccc(C#C[C@@](C)(O)c3ncccn3)cc1-2 CHEMBL3696713 Ki 2.4 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)OC[C@@H](N(C)C)c2sc(C(N)=O)nc2-3)no1 CHEMBL3696559 Ki 2.5 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)OC[C@H](N(C)C)c2sc(C(N)=O)nc2-3)no1 CHEMBL3696561 Ki 2.5 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)C2CC(C2)n2cc(C(N)=O)nc2-3)C1=O CHEMBL3696600 Ki 2.5 nM
CC(=O)N(Cc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2)C(C)C CHEMBL3696662 Ki 2.5 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1nc(C2CC2)n[nH]1)CO CHEMBL3692558 Ki 2.6 nM
C[C@@](O)(C#Cc1cc2c(cc1F)C1CC(C1)c1[nH]c(C(N)=O)nc1-2)c1ncccn1 CHEMBL3696574 Ki 2.6 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C2(CO3)OCCO2)C1=O CHEMBL3700230 Ki 2.6 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NCC4COC4)n2CCO3)no1 CHEMBL4106592 Ki 2.6 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](O)(CC#N)CO3)C1=O CHEMBL3700188 Ki 2.8 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](O)(CC#N)CO3)C1=O CHEMBL3700194 Ki 2.8 nM
CN1CCCC(O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2CCO3)C1=O CHEMBL3692508 Ki 2.9 nM
Cc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3696629 Ki 2.9 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(O)c4ccnn4C)n2C2CC3C2)no1 CHEMBL4109222 Ki 2.9 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2 CHEMBL4065087 Ki 2.9 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1cc[nH]n1 CHEMBL3692390 Ki 3.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCCC3)ccc1C1CC2C1 CHEMBL3692392 Ki 3.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCc1sc(C(N)=O)nc1-2)CO CHEMBL3692443 Ki 3.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(O)CF)cc1-2 CHEMBL3692466 Ki 3.0 nM
NC(=O)c1nc2c(s1)CCOc1cc(F)c(C#CC(O)(CF)CF)cc1-2 CHEMBL3692470 Ki 3.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(O)CO)cc1-2 CHEMBL3692476 Ki 3.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(=O)O)nc1-2 CHEMBL3692477 Ki 3.0 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2cc(C(N)=O)nc2-3)no1 CHEMBL4107102 Ki 3.0 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)no1 CHEMBL4113282 Ki 3.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cc(CC#N)on1 CHEMBL3696677 Ki 3.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(-c3nnc(C4CC4)s3)n1C1CC2C1 CHEMBL3696680 Ki 3.0 nM
Cc1cc(C(C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CC(CO)O3)no1 CHEMBL3696692 Ki 3.0 nM
Cc1nnc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C(F)(F)CO3)o1 CHEMBL3932757 Ki 3.0 nM
Cc1nnc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C(F)(F)CO3)o1 CHEMBL4111194 Ki 3.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@](C)(F)CO3)C1=O CHEMBL3700202 Ki 3.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@](C)(F)CO3)C1=O CHEMBL3700208 Ki 3.0 nM
CN1CCCC(O)(C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)C1=O CHEMBL3692493 Ki 3.0 nM
CC(O)(C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2)CF CHEMBL3692502 Ki 3.1 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CNC(=O)C1CC1(F)F CHEMBL3696658 Ki 3.1 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](O)(C(F)(F)F)CO3)C1=O CHEMBL3696727 Ki 3.1 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](O)(C(F)(F)F)CO3)C1=O CHEMBL3696729 Ki 3.1 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCNC3=O)c(F)cc1OCC2 CHEMBL3692542 Ki 3.2 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](C)CO3)no1 CHEMBL3700191 Ki 3.2 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](C)CO3)no1 CHEMBL3700196 Ki 3.2 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC[C@H]4CCOC4)n2CCO3)no1 CHEMBL4114527 Ki 3.2 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC[C@@H]4CCOC4)n2CCO3)no1 CHEMBL3938582 Ki 3.2 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](O)CO3)no1 CHEMBL4109785 Ki 3.2 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cccnn1 CHEMBL3692485 Ki 3.2 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](O)CO3)no1 CHEMBL3893684 Ki 3.23 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2C2CC2)no1 CHEMBL4110245 Ki 3.3 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2CNC(=O)C2CC2)no1 CHEMBL4115368 Ki 3.3 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NCC4CCOCC4)n2CCO3)no1 CHEMBL4108752 Ki 3.3 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C2(COC2)CO3)C1=O CHEMBL3700324 Ki 3.3 nM
COc1ncc(F)cc1[C@@H](O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC3(O)CCCC3)cc1-2 CHEMBL3696642 Ki 3.4 nM
COc1ncc(F)cc1[C@H](O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC3(O)CCCC3)cc1-2 CHEMBL3696643 Ki 3.4 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@H](F)CO3)no1 CHEMBL4109485 Ki 3.5 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)c1c-2nc(C(N)=O)n1Cc1ccccc1Cl CHEMBL3696682 Ki 3.6 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C1CC1 CHEMBL3692545 Ki 3.7 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCC3)ccc1C1CC2C1 CHEMBL3696660 Ki 3.7 nM
NC(=O)c1nc2c(s1)CCOc1ccc(C#CC3(O)CCCC3)cc1-2 CHEMBL3692361 Ki 4.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NCC1COC1 CHEMBL3692445 Ki 4.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(O)COC)cc1-2 CHEMBL3692462 Ki 4.0 nM
CN1CCC(O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)C1=O CHEMBL3696569 Ki 4.0 nM
CN1CCC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC4CCOCC4)n2CCO3)C1=O CHEMBL3700271 Ki 4.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(COc4ccccc4Cl)n2CCO3)C1=O CHEMBL3700318 Ki 4.0 nM
COC[C@@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1[C@H](O)c1ccnn1C CHEMBL3696615 Ki 4.1 nM
COC[C@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1[C@H](O)c1ccnn1C CHEMBL3696616 Ki 4.1 nM
COC[C@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1[C@@H](O)c1ccnn1C CHEMBL3696632 Ki 4.1 nM
COC[C@@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1[C@@H](O)c1ccnn1C CHEMBL3696633 Ki 4.1 nM
CC(C)(O)COc1ccc(C#N)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 CHEMBL4211057 IC50 4.1 nM
Cc1nnc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](C)(F)CO3)o1 CHEMBL4111467 Ki 4.2 nM
Cc1nnc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](C)(F)CO3)o1 CHEMBL3953974 Ki 4.2 nM
CC(C)NCc1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3700315 Ki 4.2 nM
C[C@@](O)(C#Cc1ccc2c(c1)N(c1nc(N)ncc1Cl)CC2)c1nccs1 CHEMBL4552922 IC50 4.2 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(O)c3ccccn3)cc1-2 CHEMBL3692526 Ki 4.3 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](F)CO3)no1 CHEMBL4110082 Ki 4.4 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](F)CO3)no1 CHEMBL3985070 Ki 4.4 nM
Cn1nccc1C(O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC3(O)CCCC3)cc1-2 CHEMBL3696604 Ki 4.5 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2CN2CCCC2)no1 CHEMBL4109591 Ki 4.5 nM
CC(C)(O)Cn1cc(-c2c(C(N)=O)nc3n2C2CC(C2)c2ccc(C#CC4(O)CCCC4)cc2-3)cn1 CHEMBL3696591 Ki 4.6 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CNC(=O)C1(O)CC1 CHEMBL3696657 Ki 4.6 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C2CC3C2)no1 CHEMBL4111828 Ki 4.6 nM
CN1CC(F)C(Oc2ccc(C#N)cc2Nc2nccc(-c3cc(C#N)c4c(c3)[C@@](C)(CO)CN4)n2)C1 CHEMBL4211990 IC50 4.6 nM
C[C@@](O)(C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1nc(C2CC2)n[nH]1)c1ncccn1 CHEMBL3696580 Ki 4.7 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3nc(C(N)=O)c4ccccn34)c2)C1=O CHEMBL4205172 Ki 4.7 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](C)(F)CO3)no1 CHEMBL3902973 Ki 4.8 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](C)(F)CO3)no1 CHEMBL4112453 Ki 4.8 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(F)(F)F)n2CCO3)no1 CHEMBL4109399 Ki 4.9 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CNC=O CHEMBL3696618 Ki 4.9 nM
C[C@@](O)(C#Cc1ccc(F)c(-c2c[nH]c3cnc(N)nc23)c1)c1nccs1 CHEMBL4445719 Kd 4.9 nM
CN1CCN(CCNC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)CC1 CHEMBL3692425 Ki 5.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NCC1CCOCC1 CHEMBL3692434 Ki 5.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCc1sc(C(N)=O)nc1-2 CHEMBL3692444 Ki 5.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCc1sc(C(N)=O)nc1-2)CF CHEMBL3692471 Ki 5.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCc4cccnc43)ccc1OCC2 CHEMBL3692503 Ki 5.1 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@H](O)CO3)C1=O CHEMBL3700168 Ki 5.1 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@H](O)CO3)C1=O CHEMBL3700175 Ki 5.1 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C1(O)CN(C(=O)C2CC2)C1 CHEMBL3696636 Ki 5.2 nM
COCCN(C)c1cc(-c2cn[nH]c2)c2cc(C#CC(C)(O)c3nccs3)ccc2n1 CHEMBL4793033 IC50 5.2 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1cn[nH]c1 CHEMBL3692400 Ki 5.4 nM
CNC(=O)c1ccc(OC(C)C)c(Nc2nccc(-c3cc(C#N)c4c(c3)[C@@](C)(CO)CN4)n2)c1 CHEMBL4214523 IC50 5.5 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C2CC2)C1=O CHEMBL3696631 Ki 5.6 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C[C@@H](CO)O3)no1 CHEMBL3904220 Ki 5.6 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#CC3(O)CCCCC3)cc1-2 CHEMBL3696541 Ki 5.7 nM
COC[C@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1Cc1ccnn1C CHEMBL3696612 Ki 5.7 nM
COC[C@@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1Cc1ccnn1C CHEMBL3696613 Ki 5.7 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C(C)(C)O)no1 CHEMBL4113052 Ki 5.7 nM
CN1CCCC(O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)C1=O CHEMBL3692509 Ki 5.9 nM
CCOc1ccn2c(-c3cccc(C#C[C@]4(O)CCN(C)C4=O)c3)nc(C(N)=O)c2c1 CHEMBL4210066 Ki 5.9 nM
CN1CCC(O)(C#Cc2ccc(F)c(-c3c[nH]c4cnc(N)nc34)c2)C1=O CHEMBL4448524 IC50 5.9 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NC1COC1 CHEMBL3692413 Ki 6.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NC1CCOCC1 CHEMBL3692438 Ki 6.0 nM
CC(=O)N1CC(c2c(C(N)=O)nc3n2C2CC(C2)c2ccc(C#CC4(O)CCCC4)cc2-3)C1 CHEMBL3696602 Ki 6.0 nM
CN1CCC(O)(C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2Cc2ccnn2C)C1=O CHEMBL3696603 Ki 6.1 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2CN2CCCC2)C1=O CHEMBL3696688 Ki 6.1 nM
Cn1nccc1C(O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@@](C)(O)c3ncccn3)cc1-2 CHEMBL3696647 Ki 6.14 nM
CC(O)(C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1-c1nc(C2CC2)n[nH]1)CO CHEMBL3692546 Ki 6.5 nM
CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ccnc3[nH]ccc23)c1)c1nccs1 CHEMBL4648033 IC50 6.59 nM
Cn1nccc1C(O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3696562 Ki 6.6 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2CCO3)no1 CHEMBL4110488 Ki 6.6 nM
NC(=O)c1nc2n(c1C1CC1)C1CC(C1)c1cc(F)c(C#CC3(O)CCNC3=O)cc1-2 CHEMBL3696614 Ki 6.7 nM
CC(O)(C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2)c1ccccn1 CHEMBL3692511 Ki 6.8 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C(F)(F)CO3)no1 CHEMBL4115134 Ki 6.8 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C(C)(C)O)C1=O CHEMBL3696625 Ki 6.85 nM
CC(O)(C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2)c1ncccn1 CHEMBL3692553 Ki 6.9 nM
Cn1c(C(N)=O)nc2c1C1CC(C1)c1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3696711 Ki 6.9 nM
CN1CC[C@@](O)(C#Cc2cc3c(cc2F)OCCc2cc(C(N)=O)sc2-3)C1=O CHEMBL3696716 Ki 6.9 nM
CC(O)(C#Cc1cc2c(cc1F)OCCc1sc(C(N)=O)nc1-2)c1ccccn1 CHEMBL3692447 Ki 7.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#C[C@@](C)(O)c3noc(C)n3)cc1-2 CHEMBL3692451 Ki 7.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(O)COC)cc1-2 CHEMBL3692465 Ki 7.0 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2C(F)(F)F)no1 CHEMBL4115115 Ki 7.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C1(O)COC1 CHEMBL3696635 Ki 7.0 nM
C[C@@](O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(F)(F)CO2)c1ncccn1 CHEMBL3700270 Ki 7.0 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C1CC2C1)c1ccccn1 CHEMBL3692524 Ki 7.1 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(O)c1cc(F)cc(F)c1 CHEMBL3692512 Ki 7.2 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2c-3nc(C(N)=O)c2C(F)(F)F)no1 CHEMBL4107212 Ki 7.2 nM
Cn1nccc1C(O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696527 Ki 7.2 nM
C[C@@](O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(-c3nc(C4CC4)n[nH]3)n1CCO2)c1ncccn1 CHEMBL3696582 Ki 7.2 nM
C[C@]1(CO)CNc2c(C#N)cc(-c3ccnc(Nc4cc(C#N)ccc4OC4CC4)n3)cc21 CHEMBL4212714 IC50 7.4 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1CCO2)c1nncs1 CHEMBL3696701 Ki 7.5 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1Cc1ccccc1F CHEMBL3692380 Ki 7.5 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](C#N)CO3)C1=O CHEMBL3700164 Ki 7.6 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](C#N)CO3)C1=O CHEMBL3700165 Ki 7.6 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C1CN(C(=O)OC(C)(C)C)C1 CHEMBL3692543 Ki 7.7 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1[C@H](O)C1CN(C(=O)OC(C)(C)C)C1 CHEMBL3696645 Ki 7.7 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1[C@@H](O)C1CN(C(=O)OC(C)(C)C)C1 CHEMBL3696646 Ki 7.7 nM
Cn1nccc1Cc1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696573 Ki 7.8 nM
Cn1c(C(N)=O)nc2c1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696585 Ki 7.8 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)CF CHEMBL3692429 Ki 8.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NCC1CCOC1 CHEMBL3692435 Ki 8.0 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#C[C@@](C)(O)c3cc(C)on3)cc1-2 CHEMBL3692489 Ki 8.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C2(CCC2)CO3)no1 CHEMBL4115138 Ki 8.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C[C@H](CF)O3)no1 CHEMBL3982610 Ki 8.1 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C[C@@H](CF)O3)no1 CHEMBL4107810 Ki 8.1 nM
CCS(=O)(=O)N1CCN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CC1 CHEMBL4644825 IC50 8.22 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C1CC2C1)c1ncccn1 CHEMBL3692552 Ki 8.3 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CNC(=O)C1CCC1 CHEMBL3696651 Ki 8.4 nM
Cc1nc([C@@](O)(C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)CF)no1 CHEMBL4112306 Ki 8.6 nM
Cc1nc([C@](O)(C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)CF)no1 CHEMBL3903360 Ki 8.6 nM
CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ncc23)c1)c1nccs1 CHEMBL4642561 IC50 8.63 nM
Cc1cc(-c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#C[C@@](C)(O)c4noc(C)n4)cc2-3)[nH]n1 CHEMBL3696590 Ki 8.7 nM
Cn1cncc1C(O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC3(O)CCCC3)cc1-2 CHEMBL3696583 Ki 8.8 nM
CC(C)(O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)ccc1-2 CHEMBL3696622 Ki 8.9 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(CN4CCCC4)n2C2CC3C2)C1=O CHEMBL3696694 Ki 8.9 nM
COCC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1nc(C2CC2)n[nH]1 CHEMBL3692563 Ki 9.0 nM
CN1CC[C@@](O)(C#Cc2ccnc(-n3nc(C(N)=O)cc3N)c2)C1=O CHEMBL4203779 Ki 9.4 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C(F)(F)F CHEMBL3692547 Ki 9.5 nM
COCC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C1CC2C1 CHEMBL3692527 Ki 9.7 nM
CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4645565 IC50 9.7 nM
Cc1nnc(C(C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C(C)CO3)o1 CHEMBL3700186 Ki 9.8 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCC3)c(F)cc1OCC2 CHEMBL3692374 Ki 10.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1cnn(CC(C)(C)O)c1 CHEMBL3692399 Ki 10.0 nM
Cc1nc(C(C)(O)C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)no1 CHEMBL3692428 Ki 10.0 nM
Cn1cc(-c2c(C(N)=O)nc3n2CCOc2ccc(C#CC(C)(C)O)cc2-3)cn1 CHEMBL3692460 Ki 10.0 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(O)CO)cc1-2 CHEMBL3692491 Ki 10.0 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1CCO2)c1nnco1 CHEMBL3696690 Ki 10.0 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@H](O)CO3)no1 CHEMBL4107765 Ki 10.0 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@H](O)CO3)no1 CHEMBL3901871 Ki 10.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1Cc1ccccc1 CHEMBL3692379 Ki 11.0 nM
Cn1cncc1C(O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696581 Ki 11.0 nM
Cc1cc([C@@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2cc(C(N)=O)nc2-3)no1 CHEMBL3895454 Ki 11.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCCC3)ccc1O[C@H](CO)C2 CHEMBL3696697 Ki 11.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCCC3)ccc1OC(CO)C2 CHEMBL3696698 Ki 11.0 nM
C[C@]1(F)COc2ccc(C#C[C@@](C)(O)c3ncccn3)cc2-c2nc(C(N)=O)sc21 CHEMBL3700211 Ki 11.0 nM
C[C@@](O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1[C@](C)(F)CO2)c1ncccn1 CHEMBL3700223 Ki 11.0 nM
CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ccnc(N)n2)c1)c1nccs1 CHEMBL4643621 IC50 11.4 nM
C[C@@](O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4636517 IC50 11.98 nM
Cc1ncsc1C(O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692520 Ki 12.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C4CN(C(=O)C5CC5)C4)n2C2CC3C2)C1=O CHEMBL3696607 Ki 12.0 nM
Cc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#C[C@@](C)(O)c3ncccn3)cc1-2 CHEMBL3696619 Ki 12.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(CN4CCCC4)n2C2CC3C2)no1 CHEMBL4107081 Ki 12.0 nM
COC[C@@](C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(F)(F)CO2 CHEMBL3696730 Ki 12.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@H](O)CO3)no1 CHEMBL4106473 Ki 12.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@H](O)CO3)no1 CHEMBL3966194 Ki 12.0 nM
NC(=O)c1nc2n(c1C(O)c1ccn[nH]1)C1CC(C1)c1cc(F)c(C#CC3(O)CCCC3)cc1-2 CHEMBL3696610 Ki 13.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(COc3ccccc3Cl)n1CCO2 CHEMBL3696674 Ki 13.0 nM
COc1ncc(F)cc1[C@H](O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696641 Ki 13.6 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NCCN1CCOCC1 CHEMBL3692424 Ki 14.0 nM
CC(O)(C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2)CO CHEMBL3692500 Ki 14.0 nM
COC[C@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2 CHEMBL3692514 Ki 14.0 nM
COC[C@@](C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2 CHEMBL3692518 Ki 14.0 nM
COCC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C1CC1 CHEMBL3692544 Ki 14.0 nM
COc1ncc(F)cc1[C@@H](O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696640 Ki 14.0 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@H](C)CO3)no1 CHEMBL3700182 Ki 14.0 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@H](C)CO3)no1 CHEMBL3700187 Ki 14.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)(F)F)c2[C@@](C)(O)CO3)C1=O CHEMBL3700222 Ki 14.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)(F)F)c2[C@](C)(O)CO3)C1=O CHEMBL3700228 Ki 14.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)N[C@H]4CCOC4)n2CCO3)no1 CHEMBL3972760 Ki 14.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)N[C@@H]4CCOC4)n2CCO3)no1 CHEMBL4110251 Ki 14.0 nM
COC[C@@](C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1[C@@H](F)CO2 CHEMBL3700166 Ki 15.0 nM
COC[C@](C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1[C@H](F)CO2 CHEMBL3700171 Ki 15.0 nM
COC[C@@](C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1[C@H](F)CO2 CHEMBL3700172 Ki 15.0 nM
COC[C@](C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1[C@@H](F)CO2 CHEMBL3700173 Ki 15.0 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3700282 Ki 15.0 nM
CC(O)(C#Cc1ccc(N2CCC(N3CCOCC3)CC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4639487 IC50 15.3 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cc(F)ccn1 CHEMBL3692495 Ki 16.0 nM
C=Cc1cc(C(C)(O)C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)no1 CHEMBL3696611 Ki 16.0 nM
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC4CC4)n2C2CC3C2)C1=O CHEMBL3700280 Ki 16.0 nM
CN1CC[C@@](O)(C#Cc2ccnc(-n3nc(C(N)=O)cc3C3CC3)c2)C1=O CHEMBL4215454 Ki 16.0 nM
CC(O)(C#Cc1ccc(N2CCN(S(=O)(=O)C3CC3)CC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4634128 IC50 16.2 nM
CN1CCC(O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C#CC4(O)CCN(C)C4=O)n2C2CC3C2)C1=O CHEMBL3696606 Ki 17.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CNC(=O)C(C)(C)C CHEMBL3696656 Ki 17.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(Cn3cnc4ccccc43)n1CCO2 CHEMBL3696696 Ki 17.0 nM
COC[C@](C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(F)(F)CO2 CHEMBL3696728 Ki 17.0 nM
CC(=O)N1CCN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CC1 CHEMBL4640754 IC50 17.8 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1CO CHEMBL3692403 Ki 18.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1nc[nH]n1 CHEMBL3692410 Ki 18.0 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C1CC2C1)c1nc[nH]n1 CHEMBL3692560 Ki 18.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(O)c1cccc(C(F)(F)F)c1 CHEMBL3692498 Ki 19.0 nM
CN(C)C1COc2cc(F)c(C#CC(C)(O)c3ccccn3)cc2-c2nc(C(N)=O)sc21 CHEMBL3696571 Ki 19.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1-c1nc(C2CC2)no1 CHEMBL3692541 Ki 19.1 nM
COCCOc1cnc(N)nc1-c1c[nH]c2ccc(C#CC(C)(C)O)cc12 CHEMBL2334589 IC50 20.0 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(CN3CCOCC3)n1CCO2)CF CHEMBL3692467 Ki 20.0 nM
Cc1nc2ccccc2n1Cc1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3696667 Ki 20.0 nM
CN1CC[C@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)n(Cc4nn(C)c5ccccc45)c2C2CC3C2)C1=O CHEMBL3700292 Ki 20.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C1CC2C1 CHEMBL3692529 Ki 20.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CN1CCOCC1 CHEMBL3692504 Ki 21.0 nM
CN1CCC(n2cc(-c3c[nH]nc3Cl)c3cc(C#CC(C)(C)O)c(F)cc32)CC1 CHEMBL4741330 IC50 21.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(-c3cn[nH]c3)n1CCO2 CHEMBL3692458 Ki 22.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC(O)(CF)CF)c(F)cc1OCC2 CHEMBL3692469 Ki 22.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C(O)c1ccn[nH]1 CHEMBL3696609 Ki 22.0 nM
C[C@@](O)(C#Cc1ccc2c(c1)-n1nc(C(N)=O)cc1C(F)(F)CO2)CF CHEMBL3700198 Ki 22.0 nM
C[C@](O)(C#Cc1ccc2c(c1)-n1nc(C(N)=O)cc1C(F)(F)CO2)CF CHEMBL3639990 Ki 22.0 nM
CC(O)(C#Cc1ccc2nccc(-c3cn[nH]c3)c2c1)c1nccs1 CHEMBL4745533 IC50 22.1 nM
CC(O)(C#Cc1cc(-n2ccc3cnc(N)nc32)ccn1)c1nccs1 CHEMBL4447392 IC50 22.4 nM
CN(C)c1ccc(C#CC(C)(O)c2nccs2)cc1Nc1ncnc2[nH]ccc12 CHEMBL4636885 IC50 22.5 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(CC(N)=O)CO2 CHEMBL3692404 Ki 23.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(-c3cc[nH]n3)n1CCO2 CHEMBL3692464 Ki 23.0 nM
Cc1nn(C)cc1C(O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692519 Ki 23.0 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](C)(O)CO3)no1 CHEMBL4107105 Ki 23.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1ccccn1 CHEMBL3692409 Ki 24.0 nM
Cn1nccc1Cc1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3696564 Ki 24.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C[C@H](CO)O3)no1 CHEMBL4110201 Ki 24.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC(C)(C)CN4CCOCC4)n2CCO3)no1 CHEMBL4114960 Ki 24.0 nM
C[C@@H]1COc2ccc(C#C[C@@](C)(O)c3ncccn3)cc2-n2nc(C(N)=O)cc21 CHEMBL3700305 Ki 24.0 nM
C[C@H]1COc2ccc(C#C[C@@](C)(O)c3ncccn3)cc2-n2nc(C(N)=O)cc21 CHEMBL3700306 Ki 24.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1ncccn1 CHEMBL3692373 Ki 25.0 nM
Cc1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692389 Ki 25.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NC1(C)COC1 CHEMBL3692414 Ki 25.0 nM
CN(C)[C@@H]1COc2cc(F)c(C#CC(C)(C)O)cc2-c2nc(C(N)=O)sc21 CHEMBL3696536 Ki 25.0 nM
CN(C)[C@H]1COc2cc(F)c(C#CC(C)(C)O)cc2-c2nc(C(N)=O)sc21 CHEMBL3696538 Ki 25.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1ncccc1F CHEMBL3696557 Ki 25.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@](C)(O)CO3)no1 CHEMBL4109829 Ki 25.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@](C)(O)CO3)no1 CHEMBL4107992 Ki 25.0 nM
CN1CCCC(O)(C#Cc2cc(-n3ccc4cnc(N)nc43)ccn2)C1=O CHEMBL4434804 IC50 25.7 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(C(F)(F)F)n1C1CC2C1 CHEMBL3692556 Ki 26.0 nM
CC(=O)N1CCN(Cc2c(C(N)=O)nc3n2C2CC(C2)c2cc(F)c(C#CC(C)(C)O)cc2-3)CC1 CHEMBL3696532 Ki 26.0 nM
Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2CN2CCCC2)no1 CHEMBL4114905 Ki 26.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC4CCC(F)(F)CC4)n2CCO3)no1 CHEMBL4109547 Ki 26.0 nM
CNC(=O)[C@H]1Cn2cc(C(N)=O)nc2-c2cc(C#C[C@@](C)(O)c3cc(C)on3)ccc2O1 CHEMBL3700250 Ki 26.0 nM
CNC(=O)[C@@H]1Cn2cc(C(N)=O)nc2-c2cc(C#C[C@@](C)(O)c3cc(C)on3)ccc2O1 CHEMBL3700251 Ki 26.0 nM
CNc1cc(-c2cn[nH]c2)c2cc(C#CC(C)(O)c3nccs3)ccc2n1 CHEMBL4757294 IC50 26.0 nM
CN1CCC(O)(C#Cc2cc(-n3ccc4cnc(N)nc43)ccn2)C1=O CHEMBL4520250 IC50 26.1 nM
CC(O)(C#Cc1cc2c(cc1F)C1CC(C1)n1cc(C(N)=O)nc1-2)c1nc[nH]n1 CHEMBL3692513 Ki 27.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CN1CCCC1 CHEMBL3696529 Ki 27.0 nM
CC(C)NC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1ccc(C#C[C@]3(O)CCN(C)C3=O)cc1-2 CHEMBL3700281 Ki 27.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1C1(O)CCC1 CHEMBL3696621 Ki 27.4 nM
Cc1nnc(C(C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)o1 CHEMBL3696570 Ki 28.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1CCO2 CHEMBL3692360 Ki 28.0 nM
CN1CC[C@@](O)(C#Cc2ccnc(-n3ccc(C(N)=O)n3)c2)C1=O CHEMBL4203279 Ki 28.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)N(C)C)n2C2CC3C2)no1 CHEMBL3692562 Ki 30.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2[C@@H](F)CO3)no1 CHEMBL3927427 Ki 31.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(CC(=O)O)CO2 CHEMBL3692397 Ki 32.0 nM
NC(=O)c1nc2c(s1)[C@H](O)COc1ccc(C#CC3(O)CCCC3)cc1-2 CHEMBL3700266 Ki 32.0 nM
NC(=O)c1nc2c(s1)[C@@H](O)COc1ccc(C#CC3(O)CCCC3)cc1-2 CHEMBL3700267 Ki 32.0 nM
Cn1cc([C@@H](O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)cn1 CHEMBL3692516 Ki 33.0 nM
Cn1cc([C@H](O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)cn1 CHEMBL3692517 Ki 33.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2 CHEMBL3692362 Ki 34.0 nM
CCN1CCN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CC1 CHEMBL4635451 IC50 34.5 nM
Cc1ccnc(C(C)(O)C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)c1 CHEMBL3692472 Ki 35.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cnccn1 CHEMBL3692372 Ki 36.0 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C1CC2C1)CO CHEMBL3692531 Ki 36.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C1CC1 CHEMBL3692391 Ki 37.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NC1CCOC1 CHEMBL3692441 Ki 37.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C1CC1)c1ccccn1 CHEMBL3692528 Ki 37.0 nM
CC(O)(C#Cc1ccc2nc(O)cc(-c3cn[nH]c3)c2c1)c1nccs1 CHEMBL4789600 IC50 38.6 nM
Cc1nnc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2C(C)CO3)o1 CHEMBL3700181 Ki 39.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(F)(F)CO2 CHEMBL3692382 Ki 40.0 nM
CC(C)(O)C#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 CHEMBL2334586 IC50 41.0 nM
COCC1(CNC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)CC1 CHEMBL3692423 Ki 41.0 nM
CC(C)NCc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696531 Ki 42.0 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCc2cc(C(N)=O)sc2-3)no1 CHEMBL4107722 Ki 42.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)n1c-2nc(C(N)=O)c1CN1CCC(O)C1 CHEMBL3696546 Ki 43.0 nM
Cc1nc([C@](C)(O)C#Cc2ccc3c(c2)-n2nc(C(N)=O)cc2CCO3)no1 CHEMBL4112808 Ki 45.0 nM
CC1=Nc2c(F)cc(-c3nc(Nc4ccc(C5CCN(C)CC5)cn4)ncc3F)cc2C12CCCC2 CHEMBL4277900 IC50 45.0 nM
CC(O)(C#Cc1ccc(N2CCNCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4636048 IC50 47.9 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NCCN1CCCC1 CHEMBL3692421 Ki 48.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)CO CHEMBL3692411 Ki 49.0 nM
CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1cccs1 CHEMBL4642847 IC50 50.4 nM
CNC(=O)c1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#C[C@@](C)(O)c3noc(C)n3)cc1-2 CHEMBL3692490 Ki 51.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCCC3)ccc1OCC2 CHEMBL3692358 Ki 52.0 nM
COCCNCc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696542 Ki 56.0 nM
CN1CCCC(NC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)C1 CHEMBL3692432 Ki 60.0 nM
CN1CCCN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CC1 CHEMBL4643185 IC50 60.1 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2C)OCCn2cc(C(N)=O)nc2-3)no1 CHEMBL4107747 Ki 62.0 nM
C[C@@]1(O)COc2ccc(C#CC3(O)CCCC3)cc2-c2nc(C(N)=O)sc21 CHEMBL3700268 Ki 62.0 nM
C[C@]1(O)COc2ccc(C#CC3(O)CCCC3)cc2-c2nc(C(N)=O)sc21 CHEMBL3700269 Ki 62.0 nM
N#Cc1ccc2[nH]cc(-c3ccnc(N)n3)c2c1 CHEMBL2334970 IC50 63.0 nM
N#Cc1ccc2ccn(-c3ccnc(N)n3)c2c1 CHEMBL2334966 IC50 63.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cc(C#N)on1 CHEMBL3696676 Ki 64.0 nM
C[C@@](O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1CCO2)c1ncns1 CHEMBL3700312 Ki 65.0 nM
COCC(C)(O)C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2 CHEMBL3692442 Ki 68.0 nM
CN1CC[C@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2CCO3)C1=O CHEMBL3696578 Ki 68.0 nM
CN1CC[C@@](O)(C#Cc2cccc(-c3cccc(C(N)=O)c3)c2)C1=O CHEMBL4212983 Ki 68.0 nM
C[C@H]1CN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CCN1 CHEMBL4647027 IC50 69.16 nM
Nc1ncc2c(n1)-c1c([nH]c3ccc(Cl)cc13)CCC2 CHEMBL2334579 IC50 70.0 nM
COCCN(C)c1ccc(C#CC(C)(O)c2nccs2)cc1Nc1ncnc2[nH]ccc12 CHEMBL4639818 IC50 72.4 nM
COCC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(CN3CCOCC3)n1CCO2 CHEMBL3692468 Ki 73.0 nM
Nc1nccc(-n2ccc3ccc(Cl)cc32)n1 CHEMBL2334964 IC50 76.0 nM
CN1CCN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CC1 CHEMBL4645354 IC50 78.3 nM
Cn1cc(C(O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)cn1 CHEMBL3692515 Ki 82.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(COc3ccccc3F)n1CCO2 CHEMBL3696666 Ki 82.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1ncc[nH]1 CHEMBL3692483 Ki 83.0 nM
Cc1nc(N)nc2c1ccn2-c1ccnc(C#CC2(O)CCN(C)C2=O)c1 CHEMBL4556033 IC50 85.2 nM
CC(O)(C#Cc1ccc(F)c(-c2c[nH]c3cnc(N)nc23)c1)c1nccs1 CHEMBL4473180 IC50 85.5 nM
CC(O)(C#Cc1cc(-n2ccc3cnc(N)nc32)c(F)cn1)c1nccs1 CHEMBL4472671 IC50 87.3 nM
CN(C)CCNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692420 Ki 88.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(CN3CCCC3=O)n1CCO2 CHEMBL3696639 Ki 88.0 nM
Nc1nccc(-n2ccc3ccc(Br)cc32)n1 CHEMBL2334965 IC50 89.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(O)CO2 CHEMBL3692369 Ki 93.0 nM
Cc1nccn1Cc1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3696665 Ki 93.0 nM
CC(C)(O)C#CC1CCC2OCC(C)(O)c3sc(C(N)=O)nc3C2C1 CHEMBL3692377 Ki 94.0 nM
CC[C@](C)(O)C#Cc1cc2c(ccn2-c2ccnc(N)n2)cn1 CHEMBL5283456 IC50 95.0 nM
CN(C)C1COc2ccc(C#CC(C)(C)O)cc2-c2nc(C(N)=O)sc21 CHEMBL3692367 Ki 96.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C1CC1)CO CHEMBL3692523 Ki 98.0 nM
Nc1ncc2c(n1)-c1c([nH]c3ccc(Br)cc13)CCC2 CHEMBL2334583 IC50 100.0 nM
NC(=O)c1cc2n(n1)-c1cc(C#CC3(O)CCCC3)ccc1OCC21COC1 CHEMBL3700325 Ki 100.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)C(=O)N1CCC1 CHEMBL3692408 Ki 105.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NC(C)(C)C#N CHEMBL3692415 Ki 105.0 nM
CC(O)(C#Cc1ccc(N2CCCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4642207 IC50 106.7 nM
CN1CC(NC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)C1 CHEMBL3692437 Ki 109.0 nM
Cc1cnc(N)nc1-c1c[nH]c2ccc(Cl)cc12 CHEMBL2334577 IC50 110.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)C1CC(C1)c1sc(C(N)=O)cc1-2 CHEMBL3696673 Ki 110.0 nM
CC(O)(C#Cc1ccc(OC2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4643436 IC50 112.0 nM
CN1CCN(Cc2c(C(N)=O)nc3n2C2CC(C2)c2cc(F)c(C#CC(C)(C)O)cc2-3)CC1 CHEMBL3692565 Ki 120.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(Cn3cccn3)n1CCO2 CHEMBL3696644 Ki 120.0 nM
Cc1cc(C(C)(O)C#Cc2cc(-n3ccc4cnc(N)nc43)ccn2)no1 CHEMBL4453280 IC50 120.0 nM
COc1ccc(C#CC(C)(O)c2nccs2)cc1-c1c[nH]c2cnc(N)nc12 CHEMBL4458157 IC50 120.0 nM
C[C@](O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4642063 IC50 135.7 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(Cn3ncc4ccccc43)n1CCO2 CHEMBL3696668 Ki 140.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C[C@@H](CO)O2 CHEMBL3696693 Ki 140.0 nM
COC(C)(C)CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692440 Ki 142.0 nM
CC(O)C(C)(O)C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2 CHEMBL3692494 Ki 142.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cn[nH]c1 CHEMBL3692454 Ki 148.0 nM
Nc1nccc(-c2c[nH]c3ccc(Cl)cc23)n1 CHEMBL2334963 IC50 150.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1C[C@H](CO)O2 CHEMBL3696691 Ki 150.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)C(=O)N1CC(F)(F)C1 CHEMBL3692507 Ki 155.0 nM
CN1CCC(NC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)C1 CHEMBL3692436 Ki 158.0 nM
CN(C)CCN(C)c1cc(-c2cn[nH]c2)c2cc(C#CC(C)(O)c3nccs3)ccc2n1 CHEMBL4744675 IC50 159.6 nM
CC(C)N(C)Cc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696530 Ki 160.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(Cn3cc4ccc(C#N)cc4n3)n1CCO2 CHEMBL3696685 Ki 170.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C#N CHEMBL3692388 Ki 172.0 nM
CN1CCN(c2cc(-c3cn[nH]c3)c3cc(C#CC(C)(O)c4nccs4)ccc3n2)CC1 CHEMBL4762636 IC50 174.8 nM
CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3sccc23)c1)c1nccs1 CHEMBL4644359 IC50 179.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(Cn3ncc4ccc(C#N)cc43)n1CCO2 CHEMBL3696684 Ki 180.0 nM
CCc1nc(N)nc2c1ccn2-c1ccnc(C#CC2(O)CCN(C)C2=O)c1 CHEMBL4468246 IC50 189.8 nM
Nc1nccc(-c2cnc3ccc(Br)cn23)n1 CHEMBL2334591 IC50 190.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1nc(C2CC2)no1 CHEMBL3692538 Ki 190.0 nM
C#Cc1ccnc(C#Cc2ccc3ncn(-c4ccnc(N)n4)c3c2)n1 CHEMBL5196202 pIC50 199.53 nM
CC(O)(C#Cc1ccc(N2CC3CC2CN3)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4635397 IC50 199.9 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(Cn3ncc4cccnc43)n1CCO2 CHEMBL3696679 Ki 200.0 nM
CC(O)(C#Cc1cc(-n2ccc3cnc(N)nc32)ccc1F)c1nccs1 CHEMBL4587413 IC50 204.0 nM
C[C@@H]1CN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CCN1 CHEMBL4638853 IC50 209.5 nM
CC(=O)NC1COc2ccc(C#CC(C)(C)O)cc2-c2nc(C(N)=O)sc21 CHEMBL3692381 Ki 210.0 nM
CN1CC[C@](O)(C#Cc2cc3c(cc2F)OCCn2cc(C(N)=O)nc2-3)C1=O CHEMBL3696567 Ki 210.0 nM
CC(=O)N1CCN(Cc2c(C(N)=O)nc3n2CCOc2ccc(C#CC(C)(C)O)cc2-3)CC1 CHEMBL3696594 Ki 210.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(n2)-n2cc(C(N)=O)nc2CCO3)no1 CHEMBL4114601 Ki 210.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCOC3)c(F)cc1OCC2 CHEMBL3692402 Ki 212.0 nM
CC(O)(C#Cc1ccc(F)c(-n2ccc3cnc(N)nc32)c1)c1nccs1 CHEMBL4555743 IC50 215.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(=O)CO2 CHEMBL3692366 Ki 216.0 nM
COc1ccc(C#CC(C)(O)c2nccs2)cc1-n1ccc2cnc(N)nc21 CHEMBL4536229 IC50 216.0 nM
CC(O)(C#Cc1cccc(-c2c[nH]c3cnc(N)nc23)c1)c1nccs1 CHEMBL4448072 IC50 218.0 nM
CC(O)(C#Cc1cc(-n2ccc3cnc(N)nc32)ccc1C#N)c1nccs1 CHEMBL4526578 IC50 219.0 nM
COCCN(C)Cc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3696545 Ki 230.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(CN3CC[C@@H](O)C3)n1CCO2 CHEMBL3696678 Ki 230.0 nM
Nc1ncc2ccn(-c3ccnc(C#CC4(O)CCCC4)c3)c2n1 CHEMBL4450626 IC50 234.0 nM
Cn1ccnc1C(C)(O)C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2 CHEMBL3692401 Ki 239.0 nM
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1 CHEMBL4098877 IC50 244.0 nM
C#Cc1ccc2ncn(-c3ccnc(N)n3)c2c1 CHEMBL5198459 pIC50 251.19 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cc(C=O)on1 CHEMBL3696601 Ki 270.0 nM
NC(=O)c1nc2n(c1C1CC1)C1CC(C1)c1cc(F)c(C#C[C@@]3(O)CCNC3=O)cc1-2 CHEMBL3696634 Ki 270.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(COc3ccccn3)n1CCO2 CHEMBL3700316 Ki 270.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(COc4ccccc4Cl)n2CCO3)no1 CHEMBL4107198 Ki 270.0 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CC(CN2CCOCC2)O3)no1 CHEMBL4106917 Ki 280.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(C#CC(C)(C)O)n1CCO2 CHEMBL3692459 Ki 289.0 nM
COc1cc(C#CC(C)(O)c2nccs2)cc(-c2c[nH]c3cnc(N)nc23)c1 CHEMBL4458507 IC50 290.0 nM
Cc1cc(C(C)(O)C#Cc2cccc(-c3c[nH]c4cnc(N)nc34)c2)no1 CHEMBL4519315 IC50 290.0 nM
Cc1[nH]c2ccc(Cl)cc2c1-c1ccnc(N)n1 CHEMBL2334962 IC50 300.0 nM
CC(O)(C#Cc1cccc(-n2ccc3cnc(N)nc32)c1)c1nccs1 CHEMBL4569126 IC50 303.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)C(=O)N1CC(C#N)C1 CHEMBL3692449 Ki 304.0 nM
Nc1nccc(-n2cnc3ccc(Cl)cc32)n1 CHEMBL2334593 IC50 310.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1CCO2 CHEMBL3692359 Ki 310.0 nM
C#Cc1ccnc(C#Cc2ccc3ncn(-c4ccnc(N)n4)c3c2)c1 CHEMBL5175837 pIC50 316.23 nM
CC(O)(C#Cc1cc(F)cc(-c2c[nH]c3cnc(N)nc23)c1)c1nccs1 CHEMBL4444157 IC50 319.0 nM
Cc1ccc(C#CC(C)(O)c2nccs2)cc1-n1ccc2cnc(N)nc21 CHEMBL4534080 IC50 335.0 nM
CN1CC[C@@](O)(C#Cc2cccc(-n3cc(C(N)=O)c4cccnc43)c2)C1=O CHEMBL4206671 Ki 350.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 352.0 nM
CN1CCC(NC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)CC1 CHEMBL3692426 Ki 354.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)C(=O)NCC(F)F CHEMBL3692487 Ki 377.0 nM
Cc1cc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C[C@@H](CO)O3)no1 CHEMBL3941213 Ki 380.0 nM
Nc1ncc2ccn(-c3ccnc(C#CC4(O)CCC4)c3)c2n1 CHEMBL4437207 IC50 388.0 nM
CN(C)C(=O)CC1COc2ccc(C#CC(C)(C)O)cc2-c2nc(C(N)=O)sc21 CHEMBL3692398 Ki 403.0 nM
CN1CCC(O)(C#Cc2cccc(-c3c[nH]c4cnc(N)nc34)c2)C1=O CHEMBL4474571 IC50 410.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(N1CCOCC1)CO2 CHEMBL3692368 Ki 416.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 445.0 nM
CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NC1CN2CCC1CC2 CHEMBL3692433 Ki 453.0 nM
CN(C)C(=O)[C@H]1Cn2cc(C(N)=O)nc2-c2cc(C#CC3(O)CCCC3)ccc2O1 CHEMBL3700243 Ki 460.0 nM
CN(C)C(=O)C1Cn2cc(C(N)=O)nc2-c2cc(C#CC3(O)CCCC3)ccc2O1 CHEMBL3700244 Ki 460.0 nM
CC(O)(C#Cc1cccc(-c2c[nH]c3cnc(N)nc23)c1)c1cnccn1 CHEMBL4461131 IC50 468.0 nM
COCCNCc1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(C)O)cc1-2 CHEMBL3696664 Ki 470.0 nM
Nc1ncc2[nH]cc(-c3cccc(C#CC4(O)CCCC4)c3)c2n1 CHEMBL4443912 IC50 475.0 nM
CC(C)(C)CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)n2)CC1 CHEMBL257834 IC50 480.0 nM
CN(C)CCN(C)c1ccc(C#CC(C)(O)c2nccs2)cc1Nc1ncnc2[nH]ccc12 CHEMBL4648928 IC50 484.0 nM
Cc1nc(-c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)n(CC(F)(F)F)n1 CHEMBL3692482 Ki 502.0 nM
CC(O)(C#Cc1ccc2nccc(-c3cn[nH]c3)c2c1)c1cccs1 CHEMBL4787460 IC50 523.8 nM
Cc1nnc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@](C)(F)CO3)o1 CHEMBL4113010 Ki 530.0 nM
Cc1nnc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2[C@@](C)(F)CO3)o1 CHEMBL3905113 Ki 534.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)c(C(F)(F)F)n1CCO2 CHEMBL3692548 Ki 540.0 nM
C[C@H]1Cn2cc(C(N)=O)nc2-c2cc(C#CC(C)(C)O)ccc2O1 CHEMBL3696549 Ki 547.0 nM
Nc1nccc(N2CCc3ccc(Br)cc32)n1 CHEMBL2334967 IC50 550.0 nM
OC1(C#Cc2ccc3nccc(-c4cn[nH]c4)c3c2)CCCC1 CHEMBL4761327 IC50 564.1 nM
Cc1cc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)no1 CHEMBL3978002 Ki 582.0 nM
CC(O)(C#Cc1ccc2nccc(-c3cn[nH]c3)c2c1)c1ccccn1 CHEMBL4749186 IC50 590.9 nM
Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1 CHEMBL2334590 IC50 600.0 nM
CN(C)Cc1c(C(N)=O)nc2n1C1CC(C1)c1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692564 Ki 600.0 nM
C[C@@H]1Cn2cc(C(N)=O)nc2-c2cc(C#CC(C)(C)O)ccc2O1 CHEMBL3696550 Ki 620.0 nM
CCOc1nc2ccc(C#C[C@](C)(O)c3ncc(C)o3)cc2n1-c1ccnc(N)n1 CHEMBL4546659 Ki 634.0 nM
Cn1nc(-c2ccncc2)nc1-c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC(C)(C)O)cc1-2 CHEMBL3692479 Ki 635.0 nM
CC(O)(C#Cc1cc(-n2ccc3cnc(N)nc32)c(F)cc1F)c1nccs1 CHEMBL4457508 IC50 641.0 nM
OC1(C#Cc2ccc(N3CCOCC3)c(Nc3ncnc4[nH]ccc34)c2)CCCC1 CHEMBL4640652 IC50 645.0 nM
CC[C@](C)(O)C#Cc1cc2c(cn1)cnn2-c1ccnc(N)n1 CHEMBL5273263 IC50 675.0 nM
CN1CCC(Oc2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CC1 CHEMBL4648213 IC50 705.0 nM
CC(C)(O)C#Cc1cccc(-c2c[nH]c3cnc(N)nc23)c1 CHEMBL4534280 IC50 720.0 nM
CN(C)C(=O)C(C)(O)C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2 CHEMBL3692406 Ki 721.0 nM
Nc1ncc2ccn(-c3ccnc(C#CC4(O)CCCCCC4)c3)c2n1 CHEMBL4562069 IC50 748.0 nM
CC(O)(C#Cc1ccc2c(c1)-c1nc(C(N)=O)cn1CCO2)CO CHEMBL3692376 Ki 771.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-n1nc(C(N)=O)cc1CCO2 CHEMBL3700293 Ki 790.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1ccccc1F CHEMBL3692370 Ki 850.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)C(=O)NC1CC1 CHEMBL3692448 Ki 854.0 nM
CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cncnc1 CHEMBL3692371 Ki 864.0 nM
CN1CCC(CNC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)C1 CHEMBL3692422 Ki 879.0 nM
CN1CCN(Cc2c(C(N)=O)nc3n2CCOc2ccc(C#CC(C)(C)O)cc2-3)CC1 CHEMBL3696595 Ki 950.0 nM
CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(NC1CCC1)CO2 CHEMBL3639912 Ki 970.0 nM
CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#C[C@](C)(O)c3ccccn3)cc1-2 CHEMBL3696547 Ki 980.0 nM