CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 1.5 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2cccc(N3CCN(C(C)=O)CC3)c2)ncc1Cl CHEMBL3885421 IC50 1.7 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(-c3ccccc3)c2)CC1 CHEMBL3823127 IC50 2.3 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(CCOC)c2)ncc1Cl CHEMBL3884839 IC50 2.4 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 2.9 nM
CC(F)Oc1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 CHEMBL3823992 IC50 3.0 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2cccc(N3CCOCC3)c2)ncc1Cl CHEMBL3884616 IC50 3.2 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3884569 IC50 3.3 nM
CC(C)c1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 CHEMBL3823882 IC50 3.5 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 4.1 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl CHEMBL3884229 IC50 4.4 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C3CCOCC3)c2)ncc1Cl CHEMBL3884281 IC50 4.6 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(N(C)C)c2)CC1 CHEMBL3822845 IC50 5.0 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3884960 IC50(app) 5.1 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(OC(C(F)(F)F)C(F)(F)F)c2)CC1 CHEMBL3822712 IC50 5.2 nM
COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1077979 IC50 5.6 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(Cl)c2)CC1 CHEMBL3823000 IC50 5.8 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(C3CCCCC3)c2)CC1 CHEMBL3822889 IC50 6.7 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C(F)F)c2)ncc1Cl CHEMBL3884642 IC50 7.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 7.2 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(Br)c2)CC1 CHEMBL3823892 IC50 7.3 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(C)c2)ncc1Cl CHEMBL3884143 IC50 7.3 nM
CCc1cc(Nc2ncc(F)c(-c3cnc4cccnn34)n2)cc(OCCN2CCC(O)CC2)c1 CHEMBL3823303 IC50 8.0 nM
Cc1cnc(Nc2cccc(C(=O)N3CCCC3)c2)nc1N[C@H]1[C@@H](C(N)=O)[C@@H]2C=C[C@H]1C2 CHEMBL5076447 IC50 8.0 nM
CCN(C)c1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 CHEMBL3822535 IC50 9.3 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc6ncsc56)cc34)cn2)CC1 CHEMBL2407758 IC50 10.0 nM
CC(C)Oc1c(NC(=O)c2csc3c(=O)[nH]cnc23)cccc1C(=O)N1CCN(C)CC1 CHEMBL3823738 IC50 11.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2C2CC2)[C@H]2C=C[C@@H]1C2 CHEMBL5090193 IC50 11.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccoc2)[C@H]2C=C[C@@H]1C2 CHEMBL5075301 IC50 11.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc6nnsc56)cc34)cn2)CC1 CHEMBL2407759 IC50 12.0 nM
CN1CCN(c2cccc3cc(NC(=O)Nc4ccc(Oc5ccnc6[nH]ccc56)cc4)ccc23)CC1 CHEMBL4095421 Kd 12.0 nM
COc1cc(C(=O)NCCCN2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 CHEMBL3823335 IC50 13.0 nM
Nc1ncc(-c2cnn([C@H]3CC[C@H](O)CC3)c2)c2cc(-c3cccc4nnsc34)oc12 CHEMBL2408610 IC50 15.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3735673 Ki 15.0 nM
COc1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 CHEMBL3824212 IC50 15.0 nM
N#Cc1c(-c2cccc3nnsc23)oc2c(N)ncc(-c3cnn([C@H]4CC[C@H](O)CC4)c3)c12 CHEMBL2408612 IC50 17.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccnc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5094640 IC50 17.0 nM
Nc1ncc(-c2cnn([C@H]3CC[C@H](O)CC3)c2)c2c(Cl)c(-c3cccc4nnsc34)oc12 CHEMBL2408611 IC50 18.0 nM
Nc1ncc(-c2cnn([C@H]3CC[C@H](O)CC3)c2)c2c(C(F)F)c(-c3cccc4nnsc34)oc12 CHEMBL2408616 IC50 20.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccccc2F)[C@H]2C=C[C@@H]1C2 CHEMBL5088588 IC50 24.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Oc4ccccc4NC(=O)CCl)n3)cc2)CC1 CHEMBL3883823 IC50 25.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4NC(=O)CCl)n3)cc2)CC1 CHEMBL4128584 IC50 25.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccsc2)[C@H]2C=C[C@@H]1C2 CHEMBL5079990 IC50 27.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3734854 Ki 30.0 nM
COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL471474 IC50 33.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCOCCNC(=O)CCCC[C@@H]4SC[C@@H]5NC(=O)N[C@@H]54)CC3)cc2)ncc1Cl CHEMBL4129274 IC50 33.0 nM
C=CC(=O)Nc1ccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3[nH]ccc23)cc1 CHEMBL3885166 IC50 34.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 35.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 36.0 nM
Cc1cc(C(=O)N2CCN(C)CC2)ccc1NC(=O)c1csc2c(=O)[nH]cnc12 CHEMBL3823018 IC50 41.0 nM
Nc1ncc(-c2cnn([C@H]3CC[C@H](O)CC3)c2)c2c(-c3cncs3)c(-c3cccc4nnsc34)oc12 CHEMBL2408614 IC50 43.0 nM
CNC(=O)/C=C/c1c[nH]c2ncnc(OCC(C)C)c12 CHEMBL3918925 IC50 43.0 nM
NC(=O)/C=C/c1c[nH]c2ncnc(OCc3cccc(F)c3)c12 CHEMBL3969384 IC50 43.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc6cnsc56)cc34)cn2)CC1 CHEMBL2407757 IC50 44.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 44.0 nM
Nc1ncc(-c2cnn([C@H]3CC[C@H](O)CC3)c2)c2c(CF)c(-c3cccc4nnsc34)oc12 CHEMBL2408615 IC50 45.0 nM
CN1CCN(C(=O)c2cccc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c2)CC1 CHEMBL5087788 IC50 48.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 49.0 nM
COCCN1CCN(Cc2ccc(-c3cc(NC(N)=O)c(C(N)=O)s3)cc2)CC1 CHEMBL3824153 IC50 50.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3883384 IC50 50.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 50.0 nM
CNC(=O)CN(Cc1ccccc1OC(F)F)C(=O)c1c[nH]c(C(=O)N2CCCC2)n1 CHEMBL4779479 Kd 55.0 nM
C[C@@H]1CN(c2ccc3ncc(-c4ccc5[nH]nc(C6CC6)c5c4)n3n2)C[C@H](C)O1 CHEMBL5431205 IC50 55.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2cncc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5079737 IC50 56.0 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1C1CC1 CHEMBL3884914 IC50 57.0 nM
COc1cc2ncccc2cc1NC(=O)c1csc2cncnc12 CHEMBL3822972 Kd 59.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 60.0 nM
CCc1n[nH]c2ccc(-c3cnc4ccc(N5C[C@@H](C)O[C@@H](C)C5)nn34)cc12 CHEMBL5417075 IC50 63.0 nM
C[C@H](CO)n1cnnc1-c1cccc(NC(=O)Nc2nccc3ccccc23)n1 CHEMBL4764071 IC50 63.7 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5403690 IC50 64.32 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1OC CHEMBL3883761 IC50 75.0 nM
COC1=CC(O)C2=C(/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O)C1(F)F CHEMBL3629241 IC50 77.0 nM
CC(C)(C)COc1ncnc2[nH]cc(/C=C/C(N)=O)c12 CHEMBL3919781 IC50 78.0 nM
C=CC(=O)Nc1ccccc1Sc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3884813 IC50 83.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5C[C@@H](C)O[C@@H](C)C5)nn34)cc12 CHEMBL5408799 IC50 83.0 nM
CC(C)COc1ncnc2[nH]cc(/C=C/C(N)=O)c12 CHEMBL3953067 IC50 85.0 nM
CC(C)n1cnnc1-c1cccc(NC(=O)Nc2nccc3ccccc23)n1 CHEMBL4763562 IC50 85.2 nM
CCNC(=O)/C=C/c1c[nH]c2ncnc(OCC(C)C)c12 CHEMBL3919844 IC50 87.0 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1C CHEMBL3885038 IC50 92.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 93.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCOCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5091019 IC50 94.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 100.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 100.0 nM
N#Cc1cccc(-c2cnc(Nc3cccc(C(=O)N4CCCC4)c3)nc2N[C@H]2[C@@H](C(N)=O)[C@@H]3C=C[C@H]2C3)c1 CHEMBL5091399 IC50 100.0 nM
CN1CCN(c2cc(F)cc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c2)CC1 CHEMBL5085200 IC50 100.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5csc6cnccc56)cc34)cn2)CC1 CHEMBL2407760 IC50 110.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5CCO[C@@H](C)C5)nn34)cc12 CHEMBL5412383 IC50 116.0 nM
CN1CCN(c2cc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)ccn2)CC1 CHEMBL5091192 IC50 120.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 130.0 nM
Nc1ncc(-c2cnn([C@H]3CC[C@H](O)CC3)c2)c2c(-c3cccnc3)c(-c3cccc4nnsc34)oc12 CHEMBL2408613 IC50 130.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc(C(F)(F)F)c1 CHEMBL3736036 Ki 130.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5CCOC(C)(C)C5)nn34)cc12 CHEMBL5424789 IC50 131.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 150.0 nM
NC(=O)/C=C/c1c[nH]c2ncnc(OCC(F)(F)F)c12 CHEMBL3901893 IC50 150.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2cccc(C#N)c2)ccc1Oc1ccncc1 CHEMBL3822835 IC50 156.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 160.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccnc(N4CCOCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5093825 IC50 160.0 nM
CC(C)Oc1ncnc2[nH]cc(/C=C/C(N)=O)c12 CHEMBL3924740 IC50 170.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccccc2)[C@H]2C=C[C@@H]1C2 CHEMBL5085979 IC50 170.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5CC6CCC(C5)O6)nn34)cc12 CHEMBL5398734 IC50 172.0 nM
CC(C)COc1ncnc2[nH]cc(/C=C/C(=O)NC3CC3)c12 CHEMBL3934288 IC50 180.0 nM
CCCOc1ncnc2[nH]cc(/C=C/C(N)=O)c12 CHEMBL3905384 IC50 180.0 nM
NC(=O)/C=C/c1c[nH]c2ncnc(OC3CCC(F)(F)CC3)c12 CHEMBL3912681 IC50 180.0 nM
CCCn1/c(=N/C(=O)c2cccc(C(N)=O)c2)[nH]c2ccccc21 CHEMBL5414193 IC50 187.0 nM
Cn1cc(-c2cnc(N)c3oc(-c4csc5cnccc45)cc23)cn1 CHEMBL2408617 IC50 190.0 nM
CC(C)COc1ncnc2[nH]cc(/C=C/C(=O)N(C)C)c12 CHEMBL3919897 IC50 190.0 nM
CCC(C)Oc1ncnc2[nH]cc(/C=C/C(N)=O)c12 CHEMBL3916326 IC50 190.0 nM
CC(C)Nc1cc(Nc2ccn3nccc3n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4641090 IC50 190.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5C[C@@H](C)O[C@H](C)C5)nn34)cc12 CHEMBL5405261 IC50 192.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5CCO[C@H](C)C5)nn34)cc12 CHEMBL5424167 IC50 199.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc([N+](=O)[O-])c5)cc34)cn2)CC1 CHEMBL2407792 IC50 200.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5C[C@H]6C[C@@H]5CO6)nn34)cc12 CHEMBL5400329 IC50 205.0 nM
Cc1n[nH]c2ccc(-c3cnc4ccc(N5C[C@@H]6C[C@H]5CO6)nn34)cc12 CHEMBL5424796 IC50 208.0 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(F)c2)CC1 CHEMBL3823067 IC50 220.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1-c1ccoc1 CHEMBL4538743 IC50 224.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2cccnc2)[C@H]2C=C[C@@H]1C2 CHEMBL5094876 IC50 230.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccncc2)[C@H]2C=C[C@@H]1C2 CHEMBL5071152 IC50 230.0 nM
C#Cc1nc(Nc2cccc(CC(N)=O)c2)nc2[nH]cnc12 CHEMBL4786783 IC50 240.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(C(=O)N4CCCC4)cc3)ncc2-c2cccnc2)[C@H]2C=C[C@@H]1C2 CHEMBL5082986 IC50 250.0 nM
COc1cc(C(=O)NCCCN2CCN(C)CC2)ccc1NC(=O)c1csc2cncnc12 CHEMBL3822673 IC50 260.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(-c4cnco4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5073141 IC50 270.0 nM
CN1CCN(c2ccc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)cn2)CC1 CHEMBL5080176 IC50 280.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cn(C)c6cnccc56)cc34)cn2)CC1 CHEMBL2407761 IC50 340.0 nM
C=CC(=O)Oc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2OC)ncc1Cl CHEMBL3885007 IC50 342.0 nM
NC(=O)c1cnc(N2CCC[C@H](N)C2)nc1Nc1cccc(C(F)(F)F)c1 CHEMBL1835063 IC50 356.0 nM
COc1cc(O)c2c(c1Br)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL3629242 IC50 360.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc(C#N)c5)cc34)cn2)CC1 CHEMBL2407767 IC50 370.0 nM
COc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(C)(C)O[C@@H]1C(=O)/C=C\C[C@H](C)OC2=O CHEMBL3629243 IC50 380.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2-c2cccnc2)[C@H]2C=C[C@@H]1C2 CHEMBL5085436 IC50 380.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(-c4cnco4)cc3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5081576 IC50 390.0 nM
CC(C)n1cnnc1-c1cccc(NC(=O)Nc2ncnc3ccccc23)n1 CHEMBL4751918 IC50 421.2 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5csc6ccccc56)cc34)cn2)CC1 CHEMBL2407763 IC50 440.0 nM
Cc1cc(Nc2ncc(-c3cccnc3)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc1OCCN1CCCC1 CHEMBL5090869 IC50 450.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(N4CCOCC4)nc3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5084495 IC50 450.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc(CO)c5)cc34)cn2)CC1 CHEMBL2407772 IC50 470.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 484.0 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 Kd 490.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5ccc(O)cc5)cc34)cn2)CC1 CHEMBL2407777 IC50 500.0 nM
CSc1ccccc1-c1cc2c(-c3cnn(C4CCN(C(C)=O)CC4)c3)cnc(N)c2o1 CHEMBL2407779 IC50 500.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc(N)c5)cc34)cn2)CC1 CHEMBL2407793 IC50 510.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5ccccc5)cc34)cn2)CC1 CHEMBL2407958 IC50 520.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5ccccc5CC#N)cc34)cn2)CC1 CHEMBL2407787 IC50 530.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 540.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1-c1cccs1 CHEMBL4574265 IC50 543.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 Kd 600.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc(O)c5)cc34)cn2)CC1 CHEMBL2407795 IC50 610.0 nM
COC(=O)/C(C)=C/c1c[nH]c2ncnc(OCC(C)C)c12 CHEMBL3925269 IC50 620.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 630.0 nM
CC(C)COc1ncnc2[nH]cc(/C=C/C(=O)NCC3CC3)c12 CHEMBL3929132 IC50 630.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 640.0 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 Kd 650.0 nM
O=c1[nH]nc2cc(CO)c3ccc(-c4ccc[nH]4)cc3n12 CHEMBL2012881 IC50 650.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccc(F)cc2)[C@H]2C=C[C@@H]1C2 CHEMBL5087312 IC50 670.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc(N(C)C)c5)cc34)cn2)CC1 CHEMBL2407098 IC50 690.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccc(CCO)cc1)c1cccc(C(F)(F)F)c1 CHEMBL3736465 Ki 700.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 720.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 730.0 nM
CC(C)n1cnnc1-c1cccc(NC(=O)Nc2ccccn2)n1 CHEMBL4776637 IC50 734.4 nM
CC(C)COc1ncnc2[nH]cc(/C=C(\Cl)C(N)=O)c12 CHEMBL3973552 IC50 750.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc([N+](=O)[O-])c1 CHEMBL3735719 Ki 800.0 nM
COC(=O)/C=C/c1c[nH]c2ncnc(OCc3ccccc3)c12 CHEMBL3895447 IC50 800.0 nM
CC(C)COc1ncnc2[nH]cc(C#CC(N)=O)c12 CHEMBL3917140 IC50 850.0 nM
CNc1cncc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCC[C@H]4CN4CCCC4)cc3)c2)n1 CHEMBL1765781 Ki 860.0 nM
CC(C)(C)Oc1ncnc2[nH]cc(/C=C/C(N)=O)c12 CHEMBL3898170 IC50 920.0 nM
C=CC(=O)Nc1ccccc1Oc1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)n1 CHEMBL3884555 IC50 950.0 nM
COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)/C=C/C[C@H](C)OC2=O CHEMBL3629244 IC50 990.0 nM
CCC(=O)/C=C/c1c[nH]c2ncnc(OCC(C)C)c12 CHEMBL3893882 IC50 990.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5ccc(N)cc5)cc34)cn2)CC1 CHEMBL2407775 IC50 1000.0 nM
CC(=O)c1cccc(-c2cc3c(-c4cnn(C5CCN(C(C)=O)CC5)c4)cnc(N)c3o2)c1 CHEMBL2407769 IC50 1000.0 nM
Cc1nn(C)cc1-c1cnc(N)c2oc(-c3csc4cnccc34)cc12 CHEMBL2408731 IC50 1000.0 nM
NC(=O)/C=C/c1c[nH]c2ncnc(Oc3ccccc3)c12 CHEMBL3902720 IC50 1000.0 nM
COc1cc(Br)cc2[nH]cc(-c3cnc(-c4ccc[nH]4)o3)c12 CHEMBL4446434 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(N4CCOCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5084123 IC50 1000.0 nM