COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3OC)n1)CN(C)CC2 CHEMBL4859451 IC50 0.005 nM
Cc1c(N)cncc1-c1cc2cc(Nc3cc4n(n3)CC(=O)N(C(C)C)CC4)ncc2c(N)c1F CHEMBL5203557 Ki 0.013 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C(C)(F)F)n1)CN(C)CC2 CHEMBL4870155 IC50 0.027 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3cccc4c3OCC4)n1)CN(C)CC2 CHEMBL5425184 IC50 0.03 nM
CCOc1ccccc1Nc1nc(Nc2cc3c(cc2OC)CCN(C)C3)ncc1C(N)=O CHEMBL5424247 IC50 0.03 nM
COCc1ccccc1Nc1nc(Nc2cc3c(cc2OC)CCN(C)C3)ncc1C(N)=O CHEMBL4864568 IC50 0.037 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3[C@H](C)OC)n1)CN(C)CC2 CHEMBL4848845 IC50 0.037 nM
CC(C)n1cnnc1-c1cccc(N2Cc3c(cc(N4CCC[C@H]4C)nc3CN)C2=O)n1 CHEMBL5173844 Ki 0.04 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3[C@@H](C)OC)n1)CN(C)CC2 CHEMBL5433529 IC50 0.04 nM
Cc1c(-c2ccc3c(c2)/C(=C/c2cc4ccccc4[nH]2)C(=O)N3)cnc2c1NCCO2 CHEMBL4750047 IC50 0.05 nM
Cc1c(-c2cc3c(cc2F)NC(=O)/C3=C\c2cc3ncccc3[nH]2)cnc2c1NCCO2 CHEMBL4799073 IC50 0.05 nM
Cc1c(-c2cc(F)c3c(c2)/C(=C/c2ccc(C4CC4)[nH]2)C(=O)N3)cnc2c1NCCO2 CHEMBL4758698 IC50 0.05 nM
Cc1ccc(/C=C2\C(=O)Nc3ccc(-c4cnc5c(c4C)NCCO5)cc32)[nH]1 CHEMBL4786511 IC50 0.05 nM
Cc1c(N)cncc1-c1cc2cc(Nc3cc4n(n3)CC(=O)N(C(C)C)CC4)ncc2cc1F CHEMBL5202032 Ki 0.05 nM
C[C@H]1CC(=O)c2ccc(Nc3cc4c([C@](C)(N)C5CC5)cnc(OC5CC5)c4cn3)cc2C12CC2 CHEMBL5205694 IC50 0.05 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(F)c(-c4cnc5c(c4C)NCCO5)cc32)c1C CHEMBL5207975 IC50 0.05 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3S(N)(=O)=O)n1)CN(C)CC2 CHEMBL4866139 IC50 0.052 nM
Cc1c(-c2ccc3c(c2)/C(=C/c2cc4cnccc4[nH]2)C(=O)N3)cnc2c1NCCO2 CHEMBL4776545 IC50 0.06 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3CO)n1)CN(C)CC2 CHEMBL4865305 IC50 0.061 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C(C)OC)n1)CN(C)CC2 CHEMBL4855158 IC50 0.067 nM
Cc1c(-c2cc3cc(NC(=O)C4CC4)ncc3c(N)c2F)cnc2c1NCCO2 CHEMBL5433748 IC50 0.067 nM
Cc1c(-c2ccc3c(c2)/C(=C/c2cc(C#N)c[nH]2)C(=O)N3)cnc2c1NCCO2 CHEMBL4747653 IC50 0.07 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3Br)n1)CN(C)CC2 CHEMBL4863492 IC50 0.094 nM
COc1ccnc(F)c1-c1ccc2cnc(Nc3ccc(C4CCN(C)CC4)cc3)nc2c1 CHEMBL5408958 IC50 0.097 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnn(C)c5C5CC5)cc4n3)cc2)CC1 CHEMBL5425004 IC50 0.1 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C(F)(F)F)n1)CN(C)CC2 CHEMBL4872743 IC50 0.11 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3Cl)n1)CN(C)CC2 CHEMBL4866616 IC50 0.13 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C3CCCO3)n1)CN(C)CC2 CHEMBL4860645 IC50 0.16 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3c(F)cccc3F)n1)CN(C)CC2 CHEMBL4879259 IC50 0.16 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C)n1)CN(C)CC2 CHEMBL4849567 IC50 0.2 nM
CNCc1cc(OC)cc2c1CN(c1cccc(-c3nncn3[C@@H](C)C3CC3)n1)C2=O CHEMBL5071355 Ki 0.2 nM
CN(C)CCn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 CHEMBL5417139 IC50 0.2 nM
CC(=O)Nc1ccc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)cc1C CHEMBL5405626 IC50 0.2 nM
Cc1cc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)ccc1NC(=O)CN(C)C CHEMBL5427316 IC50 0.2 nM
Cc1cc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)ccc1NC(=O)CN1CCC1 CHEMBL5396156 IC50 0.2 nM
Cc1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)cc4)nc3c2)cnc2c1NCCO2 CHEMBL5421924 IC50 0.2 nM
Cc1ccncc1-c1cc2cc(NC(=O)C3CC3)ncc2c(N)c1C#N CHEMBL5172382 Ki 0.209 nM
CN1CCC(c2noc(-c3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3N[C@H](CO)c3ccccc3)n2)CC1 CHEMBL4778959 IC50 0.22 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3N3CCOC3=O)n1)CN(C)CC2 CHEMBL4857184 IC50 0.22 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3c(F)cccc3C(F)(F)F)n1)CN(C)CC2 CHEMBL4878586 IC50 0.25 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C(C)(C)C)n1)CN(C)CC2 CHEMBL4874375 IC50 0.26 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C56CCN(CC5)CC6)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4780798 IC50 0.28 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(NC3CCCC3)n1)CN(C)CC2 CHEMBL4871382 IC50 0.29 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3c(C)cccc3F)n1)CN(C)CC2 CHEMBL4873035 IC50 0.3 nM
COc1cc(CN)c2c(c1)C(=O)N(c1cccc(-c3nncn3[C@@H](C)CC(F)(F)F)n1)C2 CHEMBL5083474 Ki 0.3 nM
CC[C@H](C)n1cnnc1-c1cccc(N2Cc3c(CNC)cc(N4CCCC4)cc3C2=O)n1 CHEMBL5076500 Ki 0.3 nM
Cc1c(-c2cc3cc(Nc4cc5n(n4)CC(=O)N(C(C)C)CC5)ncc3c(N)c2F)cnc2c1NCCO2 CHEMBL5439907 IC50 0.3 nM
Cc1c(-c2ccc3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc3c2)cnc2c1NCCO2 CHEMBL5411794 IC50 0.3 nM
Cc1c(-c2ccc3cnc(Nc4ccc5c(c4)COC5)nc3c2)cnc2c1NCCO2 CHEMBL5409078 IC50 0.3 nM
Cc1c(-c2ccc3cnc(Nc4ccc5c(c4)CCOC5)nc3c2)cnc2c1NCCO2 CHEMBL5420966 IC50 0.3 nM
CC(=O)Nc1ccc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)cc1C(F)(F)F CHEMBL5400089 IC50 0.3 nM
Cc1cc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)ccc1C(N)=O CHEMBL5401820 IC50 0.3 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3P(C)(C)=O)n1)CN(C)CC2 CHEMBL5173512 IC50 0.334 nM
C[C@H]1C[C@@H](N)CN(c2ncnc3[nH]c(Cl)c(-c4cccc(C#N)c4)c23)C1 CHEMBL5423993 Ki 0.36 nM
Cc1c(CC#N)ccnc1-c1cccc(-c2cnc3c(c2Cl)C2(CC[C@@](C)(C(N)=O)C2)CN3)c1F CHEMBL5183178 Ki 0.39 nM
Cc1ccncc1-c1cc(N)c2cnc(NC(=O)C3CC3)cc2c1 CHEMBL5191495 Ki 0.391 nM
CC[C@H](C)n1cnnc1-c1cccc(N2Cc3c(CNC)cc(N(C)C)cc3C2=O)n1 CHEMBL5092129 Ki 0.4 nM
COc1cc2c(c(S(N)(=O)=O)c1)CN(c1cccc(-c3nncn3C(C)C)n1)C2=O CHEMBL5075798 Ki 0.4 nM
CC[C@@H](CC(F)(F)F)n1cnnc1-c1cccc(N2Cc3c(CNC)cc(OC)cc3C2=O)n1 CHEMBL5085639 Ki 0.4 nM
COc1ccccc1-c1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3)cc12 CHEMBL5080055 Ki 0.4 nM
Cc1c(-c2ccc3cnc(Nc4ccc5c(c4)C(C)(C)OC5)nc3c2)cnc2c1NCCO2 CHEMBL5428695 IC50 0.4 nM
CC(=O)Nc1ccc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)cc1 CHEMBL5394698 IC50 0.4 nM
Cc1c(-c2ccc3cnc(Nc4ccc(N5CCOC5=O)cc4)nc3c2)cnc2c1NCCO2 CHEMBL5417747 IC50 0.4 nM
Cc1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)nc4)nc3c2)cnc2c1NCCO2 CHEMBL5420868 IC50 0.4 nM
C[C@H]1C[C@@H](N)CN(c2ncnc3[nH]c(Cl)c(-c4cccc(C#N)c4Cl)c23)C1 CHEMBL5437932 Ki 0.4 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3c(F)cccc3CO)n1)CN(C)CC2 CHEMBL4859773 IC50 0.46 nM
CCc1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3F)cc12 CHEMBL5092805 Ki 0.47 nM
N#Cc1ccc2cc1CCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cnn(C3CCNCC3)c1)N2 CHEMBL5407530 IC50 0.5 nM
Cc1c(-c2ccc3cnc(Nc4ccc(N5CCNC5=O)cc4)nc3c2)cnc2c1NCCO2 CHEMBL5420652 IC50 0.5 nM
Cc1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)cc4)nc3c2)cnc2c1NCCC2(F)F CHEMBL5406408 IC50 0.5 nM
COc1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)cc4)nc3c2)cnc2c1NCCO2 CHEMBL5407935 IC50 0.5 nM
C[C@H]1C[C@@H](N)CN(c2ncnc3[nH]c(Cl)c(-c4cccc(CO)c4)c23)C1 CHEMBL5418420 Ki 0.58 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3F)n1)CN(C)CC2 CHEMBL4851277 IC50 0.59 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4C[C@H](N)C[C@H](C(F)(F)F)C4)c23)c1 CHEMBL5439912 Ki 0.59 nM
N#Cc1ccc2cc1CCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cn[nH]c1)N2 CHEMBL5432826 IC50 0.6 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnn(C)c5-c5ccccc5)cc4n3)cc2)CC1 CHEMBL5430021 IC50 0.6 nM
Cc1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)cc4)nc3c2)cnc2c1NCCC2=O CHEMBL5395638 IC50 0.6 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccc(F)cc4)n3)cc21 CHEMBL5435769 IC50 0.6 nM
Cc1ccncc1-c1cc2cc(NC(=O)C3CC3)ncc2c(N)n1 CHEMBL5195701 Ki 0.68 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C3CCCOC3)n1)CN(C)CC2 CHEMBL4868682 IC50 0.69 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@](C)(C(N)=O)C2)CN3)c1F CHEMBL5082573 Ki 0.8 nM
CC(C)(O)Cn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 CHEMBL5409039 IC50 0.8 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cn[nH]c5)cc4n3)cc2)CC1 CHEMBL5441105 IC50 0.8 nM
Cc1c(-c2ccc3cnc(Nc4ccc5c(c4)COCC5)nc3c2)cnc2c1NCCO2 CHEMBL5401088 IC50 0.8 nM
Cc1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)cc4)nc3c2)cnc2c1NCCC2O CHEMBL5418553 IC50 0.8 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3)n1)CN(C)CC2 CHEMBL4868487 IC50 0.88 nM
Cc1ccncc1-c1ccc2cnc(Nc3ccc(C4CCN(C)CC4)cc3)nc2c1 CHEMBL5407240 IC50 0.89 nM
CCc1c(Cl)[nH]c2nc(C(=O)N(C)C)c(N)cc12 CHEMBL5177877 Ki 0.9 nM
Cc1c(CC#N)ccnc1-c1cc(N)cc(-c2cnc3c(c2Cl)[C@]2(CC[C@](C)(C#N)C2)CN3)c1 CHEMBL5187417 Ki 0.9 nM
CC(=O)Nc1cccc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)c1 CHEMBL5395026 IC50 0.9 nM
[2H]C([2H])(O)[C@@H](Nc1nc(Nc2ccc3c(c2)C(C)(C)NC3=O)ncc1-c1nnco1)c1ccc(F)cc1 CHEMBL5396594 IC50 0.9 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 Kd apparent 1.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2CC[C@@H](N)C2)n1 CHEMBL5271703 Ki 1.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2CCC[C@H]2CO)n1 CHEMBL5274764 Ki 1.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c(-c3cccnc3)cc2N2C[C@@H]3C[C@H]2CN3)n1 CHEMBL5273201 Ki 1.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CCC3)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5404423 IC50 1.0 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnn(C)c5)cc4n3)cc2)CC1 CHEMBL5396693 IC50 1.0 nM
Cc1c(-c2ccc3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc3c2)cnn1C CHEMBL5439204 IC50 1.0 nM
CN(C)c1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)cc4)nc3c2)cnc2c1NCCO2 CHEMBL5407643 IC50 1.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CC3CCC(C2)N3C)n1 CHEMBL4797075 IC50 1.1 nM
[2H]C([2H])(O)[C@@H](Nc1nc(Nc2ccc3c(c2)C(C)(C)NC3=O)ncc1-c1nnco1)c1ccccc1 CHEMBL5424585 IC50 1.1 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(-c5ccncc5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4789200 IC50 1.2 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CC[C@H](N(C)C)C2)n1 CHEMBL4763655 IC50 1.2 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CCC[C@@H](N)C4)c23)c1 CHEMBL5404690 Ki 1.2 nM
CC(C)c1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4750822 IC50 1.3 nM
CC(C)(C)c1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4759406 IC50 1.4 nM
COc1ccc(-c2c[nH]c3nccc(Oc4c(F)cc(NC5=NCC(C)(CO)CO5)cc4F)c23)c(F)c1 CHEMBL5183864 IC50 1.4 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cccc(CN)c5)cc4n3)cc2)CC1 CHEMBL5403001 IC50 1.4 nM
Cc1c(-c2ccc3cnc(Nc4ccc([S@@](C)(=N)=O)cc4)nc3c2)cnc2c1NCCO2 CHEMBL5423968 IC50 1.4 nM
CNCc1nc(C2(C)CC2)cc2c1CN(c1cccc(N3C(=O)OC[C@@H]3C)n1)C2=O CHEMBL5206574 Ki 1.46 nM
CCc1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4758114 IC50 1.5 nM
CN(C)C(=O)c1cc(-c2cnc3[nH]ccc3c2)ccc1N CHEMBL5093381 Ki 1.5 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2CC[C@@H](O)[C@@H]2CN)n1 CHEMBL5276026 Ki 1.5 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CCCC3)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5398540 IC50 1.5 nM
CN1CCc2ccc(Nc3nc(Nc4ccccc4S(=O)(=O)N(C)C)c4c(-c5cccnc5)c[nH]c4n3)cc2C1 CHEMBL5434929 IC50 1.5 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2CCNC[C@H]2C)n1 CHEMBL5268277 Ki 1.6 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c(-c3cccnc3C)cc2N2C[C@@H]3C[C@H]2CN3)n1 CHEMBL5277299 Ki 1.7 nM
Cc1c(-c2ccc3cnc(Nc4cnc5c(c4)C(C)(C)OC5)nc3c2)cnc2c1NCCO2 CHEMBL5424400 IC50 1.7 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5403097 IC50 1.7 nM
C[C@H]1C[C@@H](N)CN(c2ncnc3[nH]c(Cl)c(-c4ccccc4)c23)C1 CHEMBL5435406 Ki 1.7 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1 CHEMBL5398202 Ki 1.7 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cc(Cl)cc(N2CCN(C)CC2)n1 CHEMBL4778477 IC50 1.8 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@H](C(N)=O)C2)CN3)c1F CHEMBL5089907 Ki 1.8 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2C[C@@H]3C[C@H]2CN3)n1 CHEMBL5276781 Ki 1.8 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2C[C@@H]3C[C@H]2CN3C)n1 CHEMBL4794486 IC50 1.9 nM
C[C@H]1COC(=O)N1c1cc(N)c2nnc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)cc2c1 CHEMBL5207610 IC50 1.9 nM
Cc1ccncc1-c1cc(N)c2nnc(NC(=O)C3CC3)cc2c1 CHEMBL5196939 Ki 1.9 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)ccc2N2C[C@@H](N)C[C@H]2CO)n1 CHEMBL5285089 Ki 1.9 nM
COc1cccc(F)c1-c1cc2c(cnn2-c2cccc(N3CCN(C)CC3)n2)cc1C#N CHEMBL4795146 IC50 2.0 nM
COc1cccc(F)c1-c1cc2c(-c3cnn(C)c3)n[nH]c2cn1 CHEMBL5277555 Ki 2.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc3cnn(C)c3cc2N2CC[C@@H](N)C2)n1 CHEMBL5279971 Ki 2.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc(-c3ncccc3C#N)cc2N2C[C@@H](N)C[C@H]2CO)n1 CHEMBL5284433 Ki 2.0 nM
N#Cc1ccc2cc1CCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cnn(CCO)c1)N2 CHEMBL5400234 IC50 2.0 nM
CN1CCc2cc(Cl)c(Nc3nc(Nc4ccccc4S(=O)(=O)N(C)C)c4c(-c5cccnc5)c[nH]c4n3)cc2C1 CHEMBL5395728 IC50 2.0 nM
CCc1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3)cc12 CHEMBL5088939 Ki 2.1 nM
Cc1c(-c2ccc3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3c2)cnc2c1NCCO2 CHEMBL5421672 IC50 2.1 nM
CS(=O)(=O)Cc1ccc(Nc2ncc3ccc(-c4cnc5c(c4C#N)NCCO5)cc3n2)cc1 CHEMBL5420011 IC50 2.1 nM
Cc1nnc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)o1 CHEMBL4779496 IC50 2.2 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)C2(CCC2)CN3)c1F CHEMBL5078234 Ki 2.2 nM
Cn1cc(Nc2ncc(C3=CCC[C@@H](NC(=O)c4ccccc4)C3)nc2C(N)=O)cn1 CHEMBL5206785 Kd 2.2 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2C[C@@H](N)C[C@H]2CO)n1 CHEMBL5285334 Ki 2.2 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2C[C@@H](O)C[C@H]2CN)n1 CHEMBL5280838 Ki 2.2 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)ccc2N2C[C@H]3C[C@@H]2CN3)n1 CHEMBL5269588 Ki 2.2 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnc6c(c5)CNCC6)cc4n3)cc2)CC1 CHEMBL5417927 IC50 2.2 nM
Cc1c(-c2ccc3cnc(Nc4ccc(CS(C)(=O)=O)cc4)nc3c2)cnc2c1NCCS2(=O)=O CHEMBL5400101 IC50 2.2 nM
Cc1c(C#N)cccc1-c1c(Cl)[nH]c2ncnc(N3C[C@@H](C)C[C@@H](N)C3)c12 CHEMBL5428265 Ki 2.2 nM
CCc1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3)c(C)c12 CHEMBL5083540 Ki 2.4 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)C2(CCCC2)CN3)c1F CHEMBL5093245 Ki 2.5 nM
COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(N4CCN(C)CC4)cc3)c2n1 CHEMBL5206133 Ki 2.5 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5429495 IC50 2.5 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C5CC5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4784181 IC50 2.6 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4748154 IC50 2.6 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CCN(C)CC2)n1 CHEMBL4760447 IC50 2.6 nM
CCc1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3)c(Cl)c12 CHEMBL5075876 Ki 2.6 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)ccc2N2CC[C@@H](N)C2)n1 CHEMBL5271378 Ki 2.6 nM
Cn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 CHEMBL5403199 IC50 2.6 nM
CCc1c(Cl)[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3)cc12 CHEMBL5086273 Ki 2.7 nM
CNCc1cc(C)c(-c2cc3c(-c4cnn(C)c4)n[nH]c3cn2)c(F)c1 CHEMBL5267404 Ki 2.7 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccc5c(c4)CN(C)CC5)nc3c2)cnc2c1NCCO2 CHEMBL5429757 IC50 2.7 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnn6c5CCCC6)cc4n3)cc2)CC1 CHEMBL5412652 IC50 2.7 nM
CCc1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)c3)c(CC)c12 CHEMBL5078580 Ki 2.8 nM
Cc1cc(-c2cnc(N)c(OCc3ccnc(C#Cc4cccc(F)c4)c3)n2)cc2c1CCN(C)C2 CHEMBL5206877 IC50 2.8 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnc[nH]5)cc4n3)cc2)CC1 CHEMBL5431039 IC50 2.8 nM
CN1CCC2(CC1)CN(c1ncnc3[nH]c(Cl)c(-c4cccc(C#N)c4)c13)CCO2 CHEMBL5415748 Ki 2.9 nM
COc1cccc(F)c1-c1ccc2[nH]nc(-c3ccc(N4CCN(C)CC4)cc3)c2n1 CHEMBL5181277 Ki 3.0 nM
CNCc1cc(F)c(-c2cc3c(-c4cnn(C)c4)n[nH]c3cn2)c(OC)c1 CHEMBL5281791 Ki 3.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc3c(cnn3C)c2N2CC[C@@H](N)C2)n1 CHEMBL5269770 Ki 3.0 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccc5c(c4)CNCC5)nc3c2)cnc2c1NCCO2 CHEMBL5432400 IC50 3.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cn[nH]c4)c[nH]c3n1)CN(C)CC2 CHEMBL5399479 IC50 3.0 nM
CCc1c[nH]c2ncc(-c3ccc(N)c(C(=O)N(C)C)n3)cc12 CHEMBL5073693 Ki 3.3 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2C[C@@H](N)C[C@H]2C)n1 CHEMBL5279231 Ki 3.3 nM
CNCc1cc(F)c(-c2cc3c(-c4cnn(C)c4)n[nH]c3cn2)c(C(F)(F)F)c1 CHEMBL5289612 Ki 3.5 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4c[nH]nc4C)c[nH]c3n1)CN(C)CC2 CHEMBL5393767 IC50 3.5 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cccnc4)c[nH]c3n1)CN(C)CC2 CHEMBL5419358 IC50 3.5 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CCNCC2)n1 CHEMBL4778314 IC50 3.8 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3c(cnn3C)c2N2C[C@H](N)C[C@H]2CO)n1 CHEMBL5267479 Ki 3.9 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnn(CCO)c5)cc4n3)cc2)CC1 CHEMBL5440958 IC50 3.9 nM
Cc1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4790192 IC50 4.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(C5CC5)o4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4784784 IC50 4.0 nM
CNC(C)c1cc(C)c(-c2cc3c(-c4cnn(C)c4)n[nH]c3cn2)c(F)c1 CHEMBL5271139 Ki 4.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4ccoc4)c[nH]c3n1)CN(C)CC2 CHEMBL5429746 IC50 4.0 nM
Cc1cc(CN2CCC2)cc(F)c1-c1cc2c(-c3cnn(C)c3)n[nH]c2cn1 CHEMBL5289695 Ki 4.1 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 4.3 nM
CNCc1ccc(Nc2ncc3c(N)cc(-c4cnc5c(c4C)NCCO5)cc3n2)cc1 CHEMBL5425905 IC50 4.3 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccc5c(c4)CCNC5)nc3c2)cnc2c1NCCO2 CHEMBL5410242 IC50 4.3 nM
COc1cc2c(cc1Nc1ncc(C(F)(F)F)c(Nc3ccccc3)n1)CN(C)CC2 CHEMBL4878650 IC50 4.4 nM
Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(O)C5CCN(C)C5)cc4)c3c2)ccc1N1CCN(C)CC1 CHEMBL5176239 IC50 4.5 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)C(C)C)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5414375 IC50 4.5 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CCCC3)c3c(-c4cccnc4)c[nH]c3n1)CN(C)CC2 CHEMBL5396262 IC50 4.5 nM
COc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cccnc4)c[nH]c3n2)ccc1N1CCOCC1 CHEMBL5395011 IC50 4.5 nM
Cc1cc(C2CCCCN2)cc(F)c1-c1cc2c(-c3cnn(C)c3)n[nH]c2cn1 CHEMBL5285291 Ki 4.6 nM
Cc1c(-c2ccc3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc3c2)nnn1C CHEMBL5437246 IC50 4.6 nM
Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(=O)N5CC(N(C)C)C5)cc4)c3c2)cc(C)c1N1CCN(C2CCN(C)CC2)CC1 CHEMBL5203333 IC50 4.8 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccc5c(c4)CCN(C)C5)nc3c2)cnc2c1NCCO2 CHEMBL5435524 IC50 4.8 nM
COc1cc2c(cc1Nc1ncc(C(F)(F)F)c(Nc3ccccc3P(C)(C)=O)n1)CN(C)CC2 CHEMBL5191529 IC50 5.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2cc3c(cc2OC)CCN(C)C3)ncc1Cl CHEMBL5196866 IC50 5.0 nM
CCNCc1cc(C)c(-c2cc3c(-c4cnn(C)c4)n[nH]c3cn2)c(F)c1 CHEMBL5290302 Ki 5.0 nM
CNCc1cccc(Nc2ncc3c(N)cc(-c4cnc5c(c4C)NCCO5)cc3n2)c1 CHEMBL5394674 IC50 5.0 nM
CN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc2[nH]cc(-c3cccnc3)c12 CHEMBL5425762 IC50 5.0 nM
CNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4761884 IC50 5.1 nM
CCc1c[nH]c2ncc(-c3cccc(C(=O)N(C)C)c3)cc12 CHEMBL5075884 Ki 5.2 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccc5c(c4)CN(C(C)C)CC5)nc3c2)cnc2c1NCCO2 CHEMBL5403804 IC50 5.2 nM
C[C@H]1C[C@@H](N)CN(c2ncnc3[nH]c(Cl)c(-c4cnn(C)c4)c23)C1 CHEMBL5414886 Ki 5.2 nM
CNCc1cc(F)c(-c2cc3c(-c4cnn(C)c4)n[nH]c3cn2)c(F)c1 CHEMBL5275738 Ki 5.4 nM
Cc1c(-c2cc(N)c3cnc(Nc4cccnc4)nc3c2)cnc2c1NCCO2 CHEMBL5436318 IC50 5.5 nM
CCOc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cccnc4)c[nH]c3n2)ccc1N1CCOCC1 CHEMBL5422718 IC50 5.5 nM
CNCCc1ccc(Nc2ncc3c(N)cc(-c4cnc5c(c4C)NCCO5)cc3n2)cc1 CHEMBL5396756 IC50 5.6 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnc(CCl)o4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5421713 IC50 5.6 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccncc4)nc3c2)cnc2c1NCCO2 CHEMBL5402971 IC50 5.7 nM
Cc1c(-c2cc(N)c3cnc(Nc4cnn(C5CC5)c4)nc3c2)cnc2c1NCCO2 CHEMBL5422788 IC50 5.7 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(C(=O)NC[C@H](F)CO)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5410537 IC50 5.9 nM
CNCCc1cccc(Nc2ncc3c(N)cc(-c4cnc5c(c4C)NCCO5)cc3n2)c1 CHEMBL5415834 IC50 6.0 nM
CN1CCc2cc(Nc3nc(Nc4ccccc4S(=O)(=O)N(C)C)c4c(-c5cccnc5)c[nH]c4n3)ccc2C1 CHEMBL5413114 IC50 6.0 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccccc4)nc3c2)cnc2c1NCCO2 CHEMBL5426390 IC50 6.2 nM
Cc1c(-c2cc(N)c3cnc(Nc4cnn(C(C)C)c4)nc3c2)cnc2c1NCCO2 CHEMBL5414817 IC50 6.4 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@@]4(CCCNC4=O)C2)CN3)c1F CHEMBL5091391 Ki 6.5 nM
COc1cccc(F)c1-c1ccc2cnc(Nc3ccc(C4CCN(C)CC4)cc3)nc2c1 CHEMBL5424570 IC50 6.5 nM
CC(C)n1cc(-c2ccc3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc3c2)cn1 CHEMBL5420572 IC50 6.6 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1ccnc(N2CCN(C)CC2)n1 CHEMBL4789558 IC50 6.7 nM
CCN1CCc2ccc(Nc3ncc4c(N)cc(-c5cnc6c(c5C)NCCO6)cc4n3)cc2C1 CHEMBL5401436 IC50 6.9 nM
CCN(CC)S(=O)(=O)c1ccccc1Nc1nc(Nc2cc3c(cc2OC)CCN(C)C3)nc2[nH]ccc12 CHEMBL5416436 IC50 7.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccccc2N2C[C@H]3C[C@@H]2CN3)n1 CHEMBL5277513 Ki 7.1 nM
CCn1cc(-c2ccc3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc3c2)cn1 CHEMBL5394328 IC50 7.1 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@@]4(CCCCNC4=O)C2)CN3)c1F CHEMBL5081453 Ki 7.2 nM
CCOC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4748045 IC50 7.3 nM
CN(C)C(=O)c1ccc(-c2c[nH]c3ncc(-c4ccc5c(c4)CN([C@H]4CC[C@](C)(O)CC4)CC5)cc23)cc1 CHEMBL5205475 IC50 7.3 nM
COc1cc2c(cc1Nc1ncc3c(N)cc(-c4cnc5c(c4C)NCCO5)cc3n1)CN(C)CC2 CHEMBL5438683 IC50 7.3 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CCC[C@H]5NCC[C@H]54)c23)c1 CHEMBL5397290 Ki 7.4 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3P(C)(C)=O)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5405678 IC50 7.5 nM
COc1cc2c(cc1Nc1ncc(C)c(Nc3ccccc3)n1)CN(C)CC2 CHEMBL4860928 IC50 7.7 nM
Cc1c(-c2cc(N)c3cnc(Nc4cnn(C)c4)nc3c2)cnc2c1NCCO2 CHEMBL5424107 IC50 7.8 nM
Cc1nn(C)cc1Nc1ncc2c(N)cc(-c3cnc4c(c3C)NCCO4)cc2n1 CHEMBL5412533 IC50 7.9 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@](C)(O)C2)CN3)c1F CHEMBL5093838 Ki 8.1 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@](C)(O)CC2)CN3)c1F CHEMBL5084042 Ki 8.2 nM
COCCN(C)C(=O)c1ccc(-c2c[nH]c3ncc(-c4ccc(N5CCN(C)CC5)cc4)nc23)cc1 CHEMBL5205962 IC50 8.2 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3c(C)cccc3Br)n1)CN(C)CC2 CHEMBL4873991 IC50 8.3 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@H](O)C2)CN3)c1F CHEMBL5092867 Ki 8.4 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@](C)(C#N)CC2)CN3)c1F CHEMBL5076389 Ki 8.4 nM
CCN1CCC(c2ncc(-c3cnc(N)c(OCc4ccncc4)c3)s2)CC1 CHEMBL4793665 IC50 8.6 nM
CN1CCN(CCCNC(=O)c2cnc(Nc3ccc4c(c3)C(C)(C)NC4=O)nc2N[C@H](CO)c2ccccc2)CC1 CHEMBL5401062 IC50 8.9 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cnn(C)c4)c[nH]c3n1)CN(C)CC2 CHEMBL5430063 IC50 9.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4ccn(C)c(=O)c4)c[nH]c3n1)CN(C)CC2 CHEMBL5410905 IC50 9.0 nM
CN1CCN(c2cc(-c3n[nH]c4ccc(-c5cnn6c5CCC6)cc34)ccn2)CC1 CHEMBL4745491 IC50 9.1 nM
CCCNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4749598 IC50 9.3 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4ccncc4)c[nH]c3n1)CN(C)CC2 CHEMBL5427968 IC50 9.5 nM
CN1CCC(c2nnc(-c3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3N[C@H](CO)c3ccccc3)o2)CC1 CHEMBL4741772 IC50 10.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3P(C)(C)=O)n1)CN(C)C2 CHEMBL5199922 IC50 10.0 nM
Cc1c(N)cncc1-c1cc(N)c2cnc(Nc3cnn(C4CC4)c3)nc2c1 CHEMBL5408268 IC50 10.4 nM
CNC(=O)N1CCN(c2cccc(-n3ncc4cnc(-c5c(F)cccc5OC)cc43)n2)CC1 CHEMBL4782526 IC50 11.0 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@](C)(C#N)C2)CN3)c1F CHEMBL5093710 Ki 11.0 nM
Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(=O)N(C)C[C@H](C)O)cc4)c3n2)cc2c1CCN(CCN1CCOCC1)C2 CHEMBL5179285 IC50 11.0 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3ccccc3C(C)(C)O)n1)CN(C)CC2 CHEMBL4856183 IC50 11.4 nM
CC(CO)CNC(=O)c1c[nH]c2ncc(-c3ccc(C4CCOCC4)c(CN(C)C)c3)cc12 CHEMBL5203070 pIC50 11.75 nM
COc1cccc(F)c1-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1 CHEMBL5290414 Ki 12.0 nM
CCn1cc(Nc2ncc3c(N)cc(-c4cnc5c(c4C)NCCO5)cc3n2)cn1 CHEMBL5435303 IC50 12.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4ccc(N)nc4)c[nH]c3n1)CN(C)CC2 CHEMBL5402375 IC50 12.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cccnc4)c[nH]c3n1)CN(C(C)C)CC2 CHEMBL5438038 IC50 12.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CC(C)(C)C3)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5436539 IC50 12.5 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccn(C)n4)nc3c2)cnc2c1NCCO2 CHEMBL5397265 IC50 12.7 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CC3(CCCNC3)C2)n1 CHEMBL4783731 IC50 13.0 nM
CCNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4745378 IC50 14.0 nM
COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3c(C)cccc3C)n1)CN(C)CC2 CHEMBL4876320 IC50 14.0 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@]2(CC[C@H](c4ncn[nH]4)C2)CN3)c1F CHEMBL5087625 Ki 14.0 nM
Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(=O)N(C)C[C@H](C)O)cc4)c3c2)cc2c1N1CCN(C)C[C@H]1CC2 CHEMBL5189318 IC50 14.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cnccc4C)c[nH]c3n1)CN(C)CC2 CHEMBL5418112 IC50 14.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 15.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 15.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 15.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(C(N)=O)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4776227 IC50 15.0 nM
CN1CCN(c2cc(-c3n[nH]c4cnc(-c5cnn6c5CCC6)cc34)ccn2)CC1 CHEMBL4746358 IC50 15.0 nM
CCc1c(C)[nH]c2nc(C(=O)N(C)C)c(N)cc12 CHEMBL5201995 Ki 15.0 nM
O=C(NCCCN1CCOCC1)Nc1ccc(Oc2ccnc3[nH]cc(C(F)(F)F)c23)c(F)c1 CHEMBL5202897 IC50 15.4 nM
CCn1ccc(Nc2ncc3c(N)cc(-c4cnc5c(c4C)NCCO5)cc3n2)n1 CHEMBL5412260 IC50 15.5 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 16.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(C56CCN(CC5)CC6)o4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4758887 IC50 16.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 17.0 nM
CNC1CCN(c2cccc(-n3ncc4cnc(-c5c(F)cccc5OC)cc43)n2)CC1 CHEMBL4739893 IC50 17.0 nM
C[C@@H]1CCCN1c1cc2c(c([C@H](N)CN)n1)CN(c1cccc(-c3nnc4n3[C@@H](C)CC4)n1)C2=O CHEMBL5435641 IC50 17.0 nM
CN1CCC2(CC1)CN(c1ncnc3[nH]cc(-c4cccc(C#N)c4)c13)CCO2 CHEMBL3972882 Ki 17.0 nM
N#Cc1ccc2cc1COCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cn[nH]c1)N2 CHEMBL5420397 IC50 17.5 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CCCCC3)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5437497 IC50 17.5 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(C(=O)NCCCN4CCOCC4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5417283 IC50 17.8 nM
Cc1ccncc1-c1cc(N)c2cnc(Nc3cnn(C4CC4)c3)nc2c1 CHEMBL5411660 IC50 17.9 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CCO[C@]5(CCNC5)C4)c23)c1 CHEMBL5435589 Ki 18.0 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(C(=O)NC[C@@H](F)C(C)(C)O)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5434634 IC50 18.5 nM
N#Cc1ccc2cc(NC(=O)C3CC3)ncc2c1N CHEMBL5173212 Ki 19.6 nM
CCc1cc(Nc2ncc(C(=O)NC)c(N[C@H](CO)c3ccccc3)n2)ccc1C#N CHEMBL4793633 IC50 20.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCC[C@@H](N)C4)c23)c1 CHEMBL5417963 Ki 21.0 nM
NC1CCCN(c2ccccc2NC(=O)c2cccc(-c3ccccc3F)c2)C1 CHEMBL5290431 Ki 22.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc3sc(C)nc3c2N2CC[C@@H](N)C2)n1 CHEMBL5277241 Ki 23.0 nM
[2H]C([2H])(O)[C@@H](Nc1nc(Nc2ccc3c(c2)C(C)(C)NC3=O)ncc1-c1nnco1)c1cccc(F)c1 CHEMBL5416273 IC50 23.9 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 24.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(-c5ccc(F)cc5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4758572 IC50 26.0 nM
Cc1nn(C)c(C)c1-c1ccc2cnc(Nc3ccc(C4CCN(C)CC4)cc3)nc2c1 CHEMBL5426590 IC50 27.0 nM
Cc1cccc(F)c1-c1cc2c(cnn2-c2ccc(N3CCN(C)CC3)cc2)cc1C#N CHEMBL4754671 IC50 28.0 nM
CN(C)C(=O)c1cc(-c2cnc3c(c2)C2(CCCC2)CN3)ccc1N CHEMBL5069623 Ki 28.0 nM
CN1CCN(c2ccc(-c3n[nH]c4ccc(-c5ccccc5F)nc34)cc2)CC1 CHEMBL5285128 Ki 28.0 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4cccc(F)c4)n3)cc21 CHEMBL5400921 IC50 28.3 nM
CC(C)NC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4761304 IC50 29.0 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5ccccc5CO)cc4n3)cc2)CC1 CHEMBL5406645 IC50 29.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cccnc4C)c[nH]c3n1)CN(C)CC2 CHEMBL5431294 IC50 29.5 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(C(=O)NCC4(O)COC4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5422210 IC50 30.1 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4cc(F)ccc4F)n3)cc21 CHEMBL5430314 IC50 30.3 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cn1 CHEMBL4785237 IC50 31.0 nM
COC(=O)N1CCN(c2cccc(-n3ncc4cnc(-c5c(F)cccc5OC)cc43)n2)CC1 CHEMBL4755396 IC50 32.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CC(N)C2)n1 CHEMBL4743506 IC50 32.0 nM
CN(C)C(=O)c1cc(-c2cnc3c(c2)C2(CC2)CN3)ccc1N CHEMBL5092646 Ki 33.0 nM
Nc1cncc(-c2cc(N)c3cnc(Nc4cnn(C5CC5)c4)nc3c2)c1 CHEMBL5421610 IC50 33.2 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CCOCC2)n1 CHEMBL4745494 IC50 34.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 35.0 nM
Cc1c(-c2cc(N)c3cnc(Nc4cnn(C)c4C)nc3c2)cnc2c1NCCO2 CHEMBL5425514 IC50 35.7 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc3c(ncn3C)c2N2CC[C@@H](N)C2)n1 CHEMBL5281003 Ki 36.0 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CCCC5(CNC5)C4)c23)c1 CHEMBL5416894 Ki 37.0 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(C(=O)NCC(F)(F)CO)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5404996 IC50 37.4 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 38.0 nM
Cc1nnc(-c2cnc(Nc3ccc4c(c3)C(C)(C)NC4=O)nc2N[C@H](CO)c2ccccc2)o1 CHEMBL5418285 IC50 38.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 39.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CCCCC2)n1 CHEMBL4798451 IC50 40.0 nM
N#Cc1ccc2cc1CCCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cn[nH]c1)N2 CHEMBL5432432 IC50 40.6 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4c(C)noc4C)c[nH]c3n1)CN(C)CC2 CHEMBL5411371 IC50 42.0 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnc(C5CC5)o4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5420367 IC50 42.6 nM
Cc1c(-c2ccc(N)c(C(=O)N(C)C)c2F)cnc2c1C1(CC1)CN2 CHEMBL5078498 Ki 43.0 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccc(F)c(F)c4)n3)cc21 CHEMBL5406326 IC50 43.9 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 44.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 44.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CCC3)c3c(-c4cccnc4)c[nH]c3n1)CN(C)CC2 CHEMBL5419415 IC50 45.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5sccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL4213767 IC50 50.0 nM
Cn1cc(-c2cc(N)c3cnc(Nc4cnn(C5CC5)c4)nc3c2)cn1 CHEMBL5401560 IC50 50.5 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cccc(CO)c5)cc4n3)cc2)CC1 CHEMBL5419396 IC50 51.0 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 IC50 52.9 nM
Cc1c(-c2cc(N)c3cnc(Nc4cc(C)n(C)n4)nc3c2)cnc2c1NCCO2 CHEMBL5397939 IC50 53.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc(-c3cnccc3C#N)cc2N2C[C@@H](N)C[C@H]2CO)n1 CHEMBL5279503 IC50 59.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1ccnc(N2CCN(C)CC2)c1 CHEMBL4776921 IC50 60.0 nM
CN1CCOc2ccccc2[C@@H](CO)Nc2nc(ncc2-c2cn[nH]c2)Nc2ccc(C#N)c(c2)C1 CHEMBL5423834 IC50 60.4 nM
Cc1c(-c2cc(N)c3cnc(Nc4cnn(C5CC5)c4)nc3c2)cnn1C CHEMBL5399247 IC50 61.1 nM
Nc1cc(-c2cccnc2)cc2nc(Nc3cnn(C4CC4)c3)ncc12 CHEMBL5409616 IC50 61.4 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4cc(F)cc(F)c4)n3)cc21 CHEMBL5438517 IC50 62.1 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 63.0 nM
CNC(=O)[C@H]1CC[C@@]2(CNc3ncc(-c4ccc(N)c(C(=O)N(C)C)c4F)c(Cl)c32)C1 CHEMBL5079859 Ki 63.0 nM
COc1cc2c(cc1Nc1nccc(Nc3ccccc3)n1)CN(C)CC2 CHEMBL4868527 IC50 64.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc(-c3c(C)nn(C)c3C#N)cc2N2C[C@@H](N)C[C@H]2CO)n1 CHEMBL5267188 Ki 65.0 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(C(=O)NCCOCCO)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5439789 IC50 65.0 nM
CN(C)C(=O)c1cc(-c2cnc3c(c2)C2(CCC2)CN3)ccc1N CHEMBL5092507 Ki 66.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 72.0 nM
CCCN(CCC)S(=O)(=O)c1ccccc1Nc1nc(Nc2cc3c(cc2OC)CCN(C)C3)nc2[nH]ccc12 CHEMBL5417561 IC50 73.0 nM
CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnc(C(F)F)o4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL5436785 IC50 73.8 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 83.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3OC(C)C)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5428398 IC50 84.0 nM
CN(C)C(=O)c1c(N)ccc(-c2cnc3c(c2Cl)[C@@]2(CC[C@@](C)(C(N)=O)C2)CN3)c1F CHEMBL5079401 Ki 85.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cc1 CHEMBL4779011 IC50 89.0 nM
COc1cc(OC)c(F)c(-c2ncc3c(-c4ccc(N5CCN(C)CC5)cc4)n[nH]c3n2)c1F CHEMBL5288662 Ki 91.0 nM
Cc1cnccc1-c1ccc2cnc(Nc3ccc(C4CCN(C)CC4)cc3)nc2c1 CHEMBL5404053 IC50 92.0 nM
C[C@H]1C[C@@H](N)CN(c2ncnc3[nH]c(Cl)c(-c4cccc(C#N)c4F)c23)C1 CHEMBL5415661 IC50 92.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 93.0 nM
NC[C@H]1CN(c2ncnc3[nH]c(Cl)c(-c4cccc(CO)c4)c23)CCO1 CHEMBL5419222 Ki 95.0 nM
Cc1c(-c2cc(N)c3cnc(Nc4ccccn4)nc3c2)cnc2c1NCCO2 CHEMBL5426604 IC50 95.7 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc(-c3c(C#N)cnn3C)cc2N2C[C@@H](N)C[C@H]2CO)n1 CHEMBL5279882 Ki 96.0 nM
C[C@H]1CC[C@@H](N)CN1c1ncnc2[nH]c(Cl)c(-c3cccc(C#N)c3)c12 CHEMBL5424617 Ki 97.0 nM
COc1ccc(CN(C)C)cc1Nc1nc(Nc2ccccc2S(=O)(=O)N(C)C)c2c(-c3cccnc3)c[nH]c2n1 CHEMBL5408991 IC50 97.5 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3P(C)(C)=O)n1)CN(C)CCC2 CHEMBL5184909 IC50 100.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c3nn(C)cc3c2N2CC[C@@H](N)C2)n1 CHEMBL5274556 Ki 100.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1ccc(N2CCOCC2)cc1 CHEMBL4796740 IC50 101.0 nM
COc1cccc(-n2ncc3cnc(-c4c(F)cccc4OC)cc32)n1 CHEMBL4789586 IC50 103.0 nM
CN(C)C(=O)c1ccc(-c2c[nH]c3ncc(-c4ccc5c(c4)CNCC5)cc23)cc1 CHEMBL5182913 IC50 107.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 108.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CCCC2)n1 CHEMBL4763505 IC50 109.0 nM
CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)c1ccccc1 CHEMBL4793479 IC50 110.0 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CCCC[C@@H](N)C4)c23)c1 CHEMBL5439779 Ki 112.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 120.0 nM
COc1ccncc1-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cc1 CHEMBL4756863 IC50 120.0 nM
Cc1cccc(F)c1-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cc1 CHEMBL4748687 IC50 121.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc(-c3cccnc3C)cc2N2C[C@@H](N)C[C@H]2CO)n1 CHEMBL5266084 Ki 124.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3OC)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5424307 IC50 127.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc(-c3cccnc3C)cc2N2C[C@@H]3C[C@H]2CN3)n1 CHEMBL5285402 Ki 129.0 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnc6n5CCOC6)cc4n3)cc2)CC1 CHEMBL5440880 IC50 130.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 140.0 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnc(C(C)(C)O)s5)cc4n3)cc2)CC1 CHEMBL5412772 IC50 140.0 nM
COc1cccc(F)c1-c1cc2c(-c3ccc(N4CCN(C)CC4)cc3)n[nH]c2cn1 CHEMBL5285188 IC50 144.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 150.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 Kd apparent 160.0 nM
N#Cc1cccc(-c2c[nH]c3ncnc(N4CCC[C@@H](O)C4)c23)c1 CHEMBL4112240 Ki 189.0 nM
Cc1c(-c2ccc3cnc(Nc4cc5n(n4)CC(=O)N(C(C)C)CC5)nc3c2)cnc2c1NCCO2 CHEMBL5428061 IC50 190.0 nM
CNC1CCc2c1ccc(F)c2-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cc1 CHEMBL4786165 IC50 193.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 196.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 210.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 210.0 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 212.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CCCC2=O)n1 CHEMBL4747110 IC50 213.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 214.0 nM
CN1CCN(c2ccc(-c3n[nH]c4ccc(-c5ccccc5)nc34)cc2)CC1 CHEMBL5271976 Ki 223.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 270.0 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@H](N)C4)c23)c1 CHEMBL5425744 Ki 273.0 nM
Cc1cccc(C)c1-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cc1 CHEMBL4798403 IC50 284.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5436257 IC50 312.5 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 330.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CCOCC3)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5427963 IC50 349.0 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4CC(C)NC(C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3184679 Kd apparent 354.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N3CCC(C)(C)CC3)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5435994 IC50 356.0 nM
N#Cc1ccc2cc1CCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cn[nH]c1)N2 CHEMBL5409588 IC50 365.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 370.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3C(C)(C)C)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5416724 IC50 386.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N2CCN(C)CC2)c1 CHEMBL4743780 IC50 408.0 nM
Cc1ccccc1-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cc1 CHEMBL4754265 IC50 410.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 452.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3C)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5430465 IC50 454.0 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5)cc4n3)cc2)CC1 CHEMBL5270339 Ki 492.0 nM
COc1cccc(F)c1-c1cc2c(NCc3ccc(N4CCN(C)CC4)cc3)n[nH]c2cn1 CHEMBL5198570 Ki 500.0 nM
Cc1ccncc1-c1ccc2nnc(NC(=O)C3CC3)cc2c1 CHEMBL5199200 Ki 510.0 nM
COc1cccc(F)c1-c1cc2c(cn1)cnn2-c1cccc(N)n1 CHEMBL4784231 IC50 518.0 nM
CCOc1cccc(F)c1-c1cc2c(cn1)cnn2-c1ccc(N2CCN(C)CC2)cc1 CHEMBL4783606 IC50 557.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 Kd apparent 566.0 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cccc(C#N)c5)cc4n3)cc2)CC1 CHEMBL5417277 IC50 580.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3Cl)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5440502 IC50 631.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccccc3F)c3cc[nH]c3n1)CN(C)CC2 CHEMBL5396218 IC50 640.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(C(=O)O)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4752693 IC50 730.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 750.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 Kd apparent 769.0 nM
COc1cc(N2CCOCC2)ccc1Nc1nc(Nc2ccccc2S(=O)(=O)N(C)C)c2c(-c3cccnc3)c[nH]c2n1 CHEMBL5439094 IC50 781.5 nM
CN1CCN(c2ccc(-n3ncc4cnc(-c5ccccc5)cc43)cc2)CC1 CHEMBL4788183 IC50 826.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 830.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 875.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL255863 Kd 890.0 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 920.0 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccccc2N2CCC[C@@H](N)C2)n1 CHEMBL5267747 IC5 953.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 980.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM