CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.0825 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C56CCN(CC5)CC6)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4780798 IC50 0.46 nM
Cc1c(-c2ccc3cnc(Nc4ccc5c(c4)C(C)(C)OC5)nc3c2)cnc2c1NCCO2 CHEMBL5428695 IC50 0.8 nM
CN1CCC(c2noc(-c3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3N[C@H](CO)c3ccccc3)n2)CC1 CHEMBL4778959 IC50 1.5 nM
Nc1ncc(-c2cnc(C3CCNCC3)s2)cc1OCc1ccncc1 CHEMBL4749141 IC50 3.0 nM
CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnn(C)c5)cc4n3)cc2)CC1 CHEMBL5396693 IC50 3.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2cc(-c3c(Cl)ccc(F)c3Cl)oc12 CHEMBL4762312 IC50 5.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 5.1 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CCC[C@H]5NCC[C@H]54)c23)c1 CHEMBL5397290 IC50 7.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 7.7 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2ccc(-c3cccc(F)c3)nc12 CHEMBL4753188 IC50 12.0 nM
N#Cc1ccc2cc1CCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cnn(C3CCNCC3)c1)N2 CHEMBL5407530 IC50 16.7 nM
CCN1CCC(c2ncc(-c3cnc(N)c(OCc4ccncc4)c3)s2)CC1 CHEMBL4793665 IC50 17.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2cc(-c3cccc(F)c3)oc12 CHEMBL4782885 IC50 18.0 nM
CCC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4568440 IC50 24.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086760 IC50 25.0 nM
CN(C)CCn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 CHEMBL5417139 IC50 27.8 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1NCc1c(Cl)ccc(F)c1Cl CHEMBL4790577 IC50 31.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 33.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1ccncc1 CHEMBL4788727 IC50 33.0 nM
Nc1ncc(-c2cnc(C3CCNCC3)s2)cc1OC1CCCCC1 CHEMBL4785602 IC50 35.0 nM
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1 CHEMBL5398202 IC50 36.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1c(Cl)ccc(F)c1Cl CHEMBL518323 IC50 39.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(-c5ccncc5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4789200 IC50 41.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4748154 IC50 42.2 nM
CC(C)c1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4750822 IC50 43.0 nM
CC(C)(C)c1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4759406 IC50 43.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C5CC5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4784181 IC50 46.0 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4CC(C)NC(C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3184679 Kd apparent 49.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 IC50 49.0 nM
Cn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 CHEMBL5403199 IC50 53.6 nM
[2H]C([2H])(O)[C@@H](Nc1nc(Nc2ccc3c(c2)C(C)(C)NC3=O)ncc1-c1nnco1)c1ccc(F)cc1 CHEMBL5396594 IC50 60.7 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 65.0 nM
N#Cc1ccc2cc1CCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cnn(CCO)c1)N2 CHEMBL5400234 IC50 66.8 nM
CCc1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4758114 IC50 68.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCC1CCCCC1 CHEMBL4757394 IC50 74.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OC1CCCCC1 CHEMBL4790293 IC50 76.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1ccnnc1 CHEMBL4742776 IC50 77.0 nM
Nc1ncc(-c2cnc(C3CCNCC3)s2)cc1OCC1CCCCC1 CHEMBL4761177 IC50 77.0 nM
CCOC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4748045 IC50 79.0 nM
CNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4761884 IC50 80.0 nM
CC(C)(O)Cn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 CHEMBL5409039 IC50 81.0 nM
Cc1nnc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)o1 CHEMBL4779496 IC50 85.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1C#Cc1ccccc1 CHEMBL4755070 IC50 87.0 nM
Cc1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 CHEMBL4790192 IC50 94.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 106.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 110.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 110.0 nM
C[C@@H](Oc1nc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4757177 IC50 110.0 nM
C[C@H]1CC[C@@H](N)CN1c1ncnc2[nH]c(Cl)c(-c3cccc(C#N)c3)c12 CHEMBL5424617 IC50 110.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 120.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1COc1ccccc1 CHEMBL4782953 IC50 120.0 nM
N#Cc1ccc2cc1CCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cn[nH]c1)N2 CHEMBL5432826 IC50 126.9 nM
CCCNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4749598 IC50 130.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(C5CC5)o4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4784784 IC50 140.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 150.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2ccc(-c3cccc(F)c3)cc12 CHEMBL4744805 IC50 160.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 170.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 180.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1ccccc1C(F)(F)F CHEMBL4751159 IC50 180.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1ccccc1Cl CHEMBL4778070 IC50 180.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 190.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1ccccc1 CHEMBL4780336 IC50 190.0 nM
COc1ccccc1COc1cc(-c2cnn(C3CCNCC3)c2)cnc1N CHEMBL4757014 IC50 197.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1C(=O)Nc1ccccc1 CHEMBL4782872 IC50 200.0 nM
CCNC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4745378 IC50 200.0 nM
CN1CCC(c2nnc(-c3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3N[C@H](CO)c3ccccc3)o2)CC1 CHEMBL4741772 IC50 200.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 210.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 210.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(C(N)=O)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4776227 IC50 240.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3Cc4cn[nH]c4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4638981 IC50 240.4 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(C56CCN(CC5)CC6)o4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4758887 IC50 280.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 290.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 290.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1CCc1ccccc1 CHEMBL4743396 IC50 310.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1cccc(Cl)c1 CHEMBL4788337 IC50 330.0 nM
Cn1cncc1COc1cc(-c2cnn(C3CCNCC3)c2)cnc1N CHEMBL4741426 IC50 330.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 363.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 390.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 406.0 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL459977 Kd 460.0 nM
CC(C)NC(=O)c1cnc(Nc2ccc3c(c2)C(C)(C)OC3=O)nc1N[C@H](CO)c1ccccc1 CHEMBL4761304 IC50 470.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 490.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1cccc(C(F)(F)F)c1 CHEMBL4793638 IC50 510.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 526.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 560.0 nM
COc1cccc(COc2cc(-c3cnn(C4CCNCC4)c3)cnc2N)c1 CHEMBL4749926 IC50 564.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 605.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 640.0 nM
C[C@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825141 IC50 680.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 706.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 766.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1ccccn1 CHEMBL4785806 IC50 790.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 820.0 nM
Cn1cc(COc2cc(-c3cnn(C4CCNCC4)c3)cnc2N)cn1 CHEMBL4787335 IC50 820.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1CNc1ccccc1 CHEMBL4800136 IC50 820.0 nM
COc1ccc(COc2cc(-c3cnn(C4CCNCC4)c3)cnc2N)cc1 CHEMBL4755176 IC50 840.0 nM
CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 CHEMBL1944698 Kd apparent 850.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1cccnc1 CHEMBL4786008 IC50 890.0 nM