CCN1CCC(c2ncc(-c3cnc(N)c(OCc4ccncc4)c3)s2)CC1 CHEMBL4793665 IC50 0.09 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.348 nM
CC(C)(Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1)C(=O)O CHEMBL4746566 IC50 0.4 nM
CC(O)(C#Cc1ccc2c(c1)N(c1nc(N)ncc1Cl)CC2)c1nccs1 CHEMBL3187788 Ki 0.4 nM
Nc1ncc(-c2ccc(OC3(C(=O)O)CCCC3)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4787152 IC50 0.6 nM
C[C@H](Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1)C(=O)O CHEMBL4759743 IC50 1.0 nM
CC(C)(Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cn1)C(=O)O CHEMBL4750540 IC50 1.3 nM
Nc1ncc(C(=O)NC2CC2)c2ccc(-c3cccc(F)c3)nc12 CHEMBL3623135 IC50 1.4 nM
CC(C)(C(=O)O)c1cccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)c1 CHEMBL4781045 IC50 1.4 nM
Nc1ncc(-c2ccc3c(c2)CC[C@@H]3C(=O)O)cc1-c1ccc(Cl)cc1 CHEMBL4783711 IC50 1.4 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 1.585 nM
CNC(=O)N1CC(NC(=O)c2cnc(N)c3nc(-c4cccc(F)c4)ccc23)C1 CHEMBL3623139 IC50 1.6 nM
Nc1ncc(-c2ccc(C3(C(=O)O)CCOCC3)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4787142 IC50 2.0 nM
Nc1ncc(-c2ccc(OCC(=O)O)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4779507 IC50 2.0 nM
CC(C)(Oc1cccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)c1)C(=O)O CHEMBL4740167 IC50 2.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1 CHEMBL4745446 IC50 2.1 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4757082 IC50 2.4 nM
Nc1ncc(-c2ccc(NCC(=O)O)nc2)cc1-c1ccc(Cl)cc1 CHEMBL4751017 IC50 2.4 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283353 IC50 2.7 nM
Nc1ncc(-c2ccc(C3(c4nn[nH]n4)CCCC3)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4777705 IC50 2.9 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 3.162 nM
Fc1cccc(-c2c[nH]c3ncccc23)c1 CHEMBL1993648 pKi 3.162 nM
OCCCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1970821 pKi 3.162 nM
CCC(=O)N1CC(NC(=O)c2cnc(N)c3nc(-c4cccc(F)c4)ccc23)C1 CHEMBL3623137 IC50 3.5 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1ccc(C(F)(F)F)cc1 CHEMBL4788172 IC50 3.5 nM
COc1ccc(-c2cc(-c3ccc(C(=O)O)cc3)cnc2N)cc1 CHEMBL4800212 IC50 3.5 nM
CC(C)(C(=O)O)c1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1 CHEMBL4760299 IC50 3.5 nM
Nc1ncc(C(=O)N[C@H]2C[C@@H](O)C2)c2ccc(-c3cccc(F)c3)nc12 CHEMBL3623136 IC50 3.7 nM
Nc1ncc(C(=O)NC2CN(C(=O)C3CC3)C2)c2ccc(-c3cccc(F)c3)nc12 CHEMBL3623138 IC50 3.7 nM
Nc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cn1 CHEMBL3754515 IC50 3.7 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)cc(Cl)n2)c1C CHEMBL1988331 pKi 3.981 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 3.981 nM
c1cnc2[nH]cc(-c3ccnc(NC4CCCCC4)n3)c2c1 CHEMBL385478 pKi 3.981 nM
OCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1989006 pKi 3.981 nM
Nc1ncc(-c2ccc(-c3nn[nH]n3)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4790042 IC50 4.0 nM
NC(=O)c1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1 CHEMBL3753424 IC50 4.1 nM
Nc1ncc(-c2ccc(C3(C(=O)O)CCCC3)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4778859 IC50 4.6 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 5.012 nM
CC(=O)NS(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1 CHEMBL4780690 IC50 5.6 nM
Cc1ccc(-c2cc(-c3ccc(C(=O)O)cc3)cnc2N)cc1 CHEMBL4741486 IC50 6.0 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 6.31 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 6.31 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 6.31 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 6.31 nM
CC(C)(COc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1)C(=O)O CHEMBL4780287 IC50 6.5 nM
N#Cc1ccc(-c2cc(-c3ccc(C(=O)O)cc3)cnc2N)cc1 CHEMBL4753817 IC50 7.2 nM
Nc1ncc(-c2cccc(C(=O)O)c2)cc1-c1ccc(Cl)cc1 CHEMBL4740781 IC50 7.6 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1ccc(F)cc1 CHEMBL4757382 IC50 7.6 nM
C[C@@H](Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1)C(=O)O CHEMBL4756318 IC50 7.9 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 7.943 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 7.943 nM
c1ccc(-c2cc3c(Nc4ccncc4)ncnn3c2)cc1 CHEMBL3326742 IC50 8.0 nM
Nc1ncc(-c2ccc(CCC(=O)O)cc2)cc1-c1ccc(Cl)cc1 CHEMBL4793121 IC50 8.1 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 8.2 nM
COCC(C)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998068 pKi 10.0 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 10.0 nM
COc1ccc2c(NC(=O)Nc3cccc(Br)n3)ccnc2c1 CHEMBL1983932 pKi 10.0 nM
O=C(c1cn[nH]c1)c1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326751 IC50 10.0 nM
O=C(c1ccoc1)c1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326749 IC50 10.0 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1cccc(Cl)c1 CHEMBL4797557 IC50 11.0 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1OCc1ccccc1 CHEMBL4756492 IC50 11.0 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1OCC1CCC1 CHEMBL4787865 IC50 11.0 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1ccccc1 CHEMBL4788138 IC50 12.0 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 12.59 nM
COc1cc(-c2ccc3[nH]nc(C(=O)Nc4ccccc4)c3c2)ccc1O CHEMBL2007002 pKi 12.59 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 12.59 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 12.59 nM
CC(C)NC(=O)c1ccc(-c2cnc(N)c(-c3ccc(C#N)cc3)c2)cc1 CHEMBL4558962 pIC50 12.59 nM
Cn1cc(-c2cc(-c3ccc(C(=O)O)cc3)cnc2N)cn1 CHEMBL4790014 IC50 13.0 nM
Nc1ncc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cn1 CHEMBL3754123 IC50 14.9 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 15.0 nM
CNC(=O)N1CC(NC(=O)c2cnc(N)c3cc(-c4cccc(F)c4)ccc23)C1 CHEMBL3623134 IC50 15.0 nM
Nc1ncc(-c2ccc3c(c2)CC[C@H]3C(=O)O)cc1-c1ccc(Cl)cc1 CHEMBL4750571 IC50 15.0 nM
CCCCNc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1968459 pKi 15.85 nM
CC(C)(Nc1nccc(-c2c[nH]c3ncccc23)n1)c1ccccc1 CHEMBL1999279 pKi 15.85 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 15.85 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 15.85 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 15.85 nM
Nc1ncc(C(=O)NC2CC2)c2ccc(-c3cccc(F)c3)cc12 CHEMBL3623130 IC50 16.0 nM
Nc1ncnc2ccc(-c3cccc(F)c3)nc12 CHEMBL3262587 IC50 17.0 nM
Cc1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)on1 CHEMBL2312654 IC50 18.0 nM
NC(=O)c1cnc(N)c2cc(-c3cccc(F)c3)ccc12 CHEMBL3623128 IC50 18.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 19.0 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)cccc12 CHEMBL1966816 pKi 19.95 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 19.95 nM
c1cnc2[nH]cc(-c3ccnc(NCC4CCCCC4)n3)c2c1 CHEMBL213207 pKi 19.95 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 19.95 nM
FC(F)(F)c1ccccc1CNc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1999153 pKi 19.95 nM
COCCN(CCOC)c1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985654 pKi 19.95 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 19.95 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 19.95 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 19.95 nM
CS(=O)(=O)c1ccc(-c2cc(-c3ccc(O)cc3)cnc2N)cc1 CHEMBL3754283 pIC50 19.95 nM
Nc1ncc(Br)c2ccc(-c3ccnc(F)c3)nc12 CHEMBL4471729 pIC50 19.95 nM
Nc1ncc(-c2cc[nH]c(=O)c2)cc1-c1ccc(Cl)cc1 CHEMBL3754730 IC50 20.0 nM
Nc1ncc(-c2ccc(C(=O)O)nc2)cc1-c1ccc(Cl)cc1 CHEMBL4799332 IC50 21.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 23.0 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 25.12 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccccc2)ncc1C(F)(F)F CHEMBL1997554 pKi 25.12 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1 CHEMBL363648 pKi 25.12 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 25.12 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 25.12 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 25.12 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 25.12 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 25.12 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 25.12 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccccc5F)c4)ccnc3c2)cn1 CHEMBL4863867 IC50 29.66 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccccc5F)c4)ccnc3c2)cc1 CHEMBL4867170 IC50 31.26 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 31.62 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 31.62 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 31.62 nM
FC(F)(F)c1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1966040 pKi 31.62 nM
CC(C)Cn1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL1965423 pKi 31.62 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 31.62 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 31.62 nM
CC(=O)N1CC(NC(=O)c2cnc(N)c3cc(-c4cccc(F)c4)ccc23)C1 CHEMBL3623133 IC50 32.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 33.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 35.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 39.81 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 39.81 nM
Cc1ccc(-c2cc3c(NCCN)ccc(C(N)=O)c3[nH]2)cc1 CHEMBL1996048 pKi 39.81 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 39.81 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 39.81 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4c(c3)OCO4)csc12 CHEMBL1993243 pKi 39.81 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 39.81 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 39.81 nM
NC(=O)c1ccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)cc1 CHEMBL1975440 pKi 39.81 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 39.81 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 39.81 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5ccccc5)c4c3)nn2)cc1 CHEMBL1982400 pKi 39.81 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCC(O)CC2)n1 CHEMBL256835 pKi 39.81 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 39.81 nM
Cc1cc2cc(-c3csc4c(-c5cccc(S(C)(=O)=O)c5)cnc(N)c34)ccc2[nH]1 CHEMBL1997822 pKi 39.81 nM
Nc1ncc(C(=O)NC2CC(O)C2)c2ccc(-c3cccc(F)c3)cc12 CHEMBL3623131 IC50 41.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877347 IC50 42.5 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1COc1ccccc1 CHEMBL4750380 IC50 43.0 nM
COc1ccc(-c2cncc(-c3ccc(C(N)=O)cc3)c2)cc1 CHEMBL3752854 IC50 45.0 nM
N#CCNC(=O)c1cnc(N)c2cc(-c3cccc(F)c3)ccc12 CHEMBL3623129 IC50 46.0 nM
NC(=O)c1ccc(-c2cncc(-c3ccc(Cl)cc3)c2)cc1 CHEMBL3754588 IC50 46.0 nM
NC(=O)c1ccc(-c2cncc(-c3ccc(OC4CC4)cc3)c2)cc1 CHEMBL3752433 IC50 48.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 50.12 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 50.12 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 50.12 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 50.12 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1 CHEMBL1090360 pKi 50.12 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 50.12 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 50.12 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 50.12 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 50.12 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 50.12 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 50.12 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 50.12 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 50.12 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 50.12 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 50.12 nM
Nc1ncnc2ccc(-c3cccc(F)c3)cc12 CHEMBL3262580 IC50 58.0 nM
Nc1cc(F)cc(-c2ccc3ncnc(N)c3c2)c1 CHEMBL3262579 IC50 60.0 nM
Cc1ccccc1-c1cc(Nc2ccnc3cc(-c4cnn(CCN(C)C)c4)ccc23)ccn1 CHEMBL4852453 IC50 61.69 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1ccccc1Cl CHEMBL4749078 IC50 62.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 63.1 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 63.1 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 63.1 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 63.1 nM
CC(C)n1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)cc21 CHEMBL1969126 pKi 63.1 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 63.1 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 63.1 nM
N#Cc1ncc2nc1OCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL248757 pKi 63.1 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(Cl)cccc12 CHEMBL1980540 pKi 63.1 nM
O=c1cc(-c2ccncc2)nc(NCc2cc(F)cc(F)c2)[nH]1 CHEMBL2003682 pKi 63.1 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 63.1 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1970203 pKi 63.1 nM
CS(=O)(=O)c1ccc(-c2cc(-c3ccc(C(N)=O)cc3)cnc2N)cc1 CHEMBL3754304 IC50 64.0 nM
O=C(c1cc2c(Nc3ccncc3)ncnn2c1)c1nnn[nH]1 CHEMBL3326750 IC50 70.0 nM
CCOC(=O)c1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326740 IC50 70.0 nM
Nc1ncnc2ccc(-c3cccc(Cl)c3)cc12 CHEMBL3262583 IC50 77.0 nM
COc1ccccc1C(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1997643 pKi 79.43 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 79.43 nM
Cc1n[nH]c2ccc(-c3cncc(OCCNS(C)(=O)=O)c3)cc12 CHEMBL1967704 pKi 79.43 nM
CN(C)c1ccc(-c2c(-c3ccc4[nH]nc(N)c4c3)nnn2Cc2ccccc2)cc1 CHEMBL1969221 pKi 79.43 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 79.43 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 79.43 nM
CC(C)(CO)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4n3CCC4)nn12 CHEMBL1996587 pKi 79.43 nM
CNCCOc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL1983855 pKi 79.43 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 79.43 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 79.43 nM
Nc1nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc2n1CC1CC1 CHEMBL1982874 pKi 79.43 nM
Nc1ncc(-c2ccccc2)cc1-c1ccc(Cl)cc1 CHEMBL3753371 IC50 83.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 88.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 90.0 nM
NC(=O)c1ccc(-c2ncc(-c3ccc(Cl)cc3)o2)cc1 CHEMBL3752536 IC50 94.0 nM
Nc1ncc(-c2ccc(=O)[nH]c2)cc1-c1ccc(Cl)cc1 CHEMBL3754762 IC50 96.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5cn(Cc6ccccc6)nn5)c4c3)nn2)cc1 CHEMBL1964288 pKi 100.0 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 100.0 nM
N#Cc1ccc2nc(N)n(-c3nc4c(s3)CCCC4)c2c1 CHEMBL1996345 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 100.0 nM
O=C1NCCc2[nH]c(-c3ccnc(Cl)c3)cc21 CHEMBL226232 pKi 100.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 100.0 nM
O=C(NCc1ccccc1)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1974250 pKi 100.0 nM
CN(C)c1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2003229 pKi 100.0 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 100.0 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 100.0 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 100.0 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 100.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 100.0 nM
Brc1ccc2[nH]nc(-c3ccccc3)c2c1 CHEMBL1994074 pKi 100.0 nM
O=C(NCc1ccccc1)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL1972142 pKi 100.0 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 100.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 108.0 nM
Cc1cccc(Nc2cc(Nc3ccccc3Cl)c(C(N)=O)cn2)n1 CHEMBL5270549 IC50 110.0 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccoc5)c4)ccnc3c2)cn1 CHEMBL4846578 IC50 119.49 nM
CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)CC1 CHEMBL2312649 IC50 120.0 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cn1 CHEMBL4850787 IC50 120.73 nM
Nc1ncnc2ccc(-c3ccccc3)cc12 CHEMBL3262570 IC50 121.0 nM
Cc1cc(NC(=O)CCNC(=O)Nc2nc(C)c(-c3ccc(-n4cccn4)cc3)s2)no1 CHEMBL1986603 pKi 125.89 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 125.89 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 125.89 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN(C)S(C)(=O)=O)c3)cc12 CHEMBL1998826 pKi 125.89 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 125.89 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 125.89 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 127.0 nM
O=C(c1cc2c(Nc3ccncc3)ncnn2c1)N1CCC1 CHEMBL3326747 IC50 130.0 nM
Nc1ncnc2ccc(-c3cc(F)cc(F)c3)cc12 CHEMBL3262584 IC50 132.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 140.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 140.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 140.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 150.0 nM
Brc1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326739 IC50 150.0 nM
Nc1ncnc2ccc(-c3ccnc(F)c3)nc12 CHEMBL3262590 IC50 150.0 nM
COc1cccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982924 pKi 158.49 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 158.49 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 158.49 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 158.49 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 pKi 158.49 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 158.49 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 158.49 nM
COc1cccc(-c2cc3c(=O)[nH]c4ccccc4n3c2)c1 CHEMBL1991356 pKi 158.49 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 158.49 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 158.49 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(C)c3c2)nnn1Cc1ccccc1 CHEMBL1983315 pKi 158.49 nM
O=C(Cc1ccccc1)Nc1cc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)ccc1Cl CHEMBL2005482 pKi 158.49 nM
CS(=O)(=O)Nc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL223460 pKi 158.49 nM
O=C(NC(CO)c1ccccc1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1964937 pKi 158.49 nM
CN(C)c1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1992363 pKi 158.49 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 pKi 158.49 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 158.49 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 158.49 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 158.49 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCN4CCOCC4)cc2-3)cn1 CHEMBL249282 pKi 158.49 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1cccc(F)c1F CHEMBL1974416 pKi 158.49 nM
O=C(c1cccc(-c2cnc3[nH]ccc3c2)c1)N1CCOCC1 CHEMBL1997872 pKi 158.49 nM
CC(C)(O)c1cnc(N)c2nc(-c3ccnc(F)c3)ccc12 CHEMBL4527085 pIC50 158.49 nM
OCc1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326743 IC50 160.0 nM
O=C(c1cc2c(Nc3ccncc3)ncnn2c1)N1CCOCC1 CHEMBL3326748 IC50 180.0 nM
Nc1cccc(-c2ccc3ncnc(N)c3c2)c1 CHEMBL3262569 IC50 189.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 190.0 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 199.53 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 199.53 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 pKi 199.53 nM
Fc1ccc(-c2nc3sccn3c2-c2ccncc2)cc1 CHEMBL2000508 pKi 199.53 nM
Cc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1F CHEMBL243518 pKi 199.53 nM
Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL1990496 pKi 199.53 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 199.53 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3o2)cc1 CHEMBL2004771 pKi 199.53 nM
O=C(Nc1nc2ccccc2n1CCCO)c1cccc([N+](=O)[O-])c1 CHEMBL210887 pKi 199.53 nM
O=C1Nc2ccccc2C1=Cc1ccc[nH]1 CHEMBL1996176 pKi 199.53 nM
COc1ccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)cc1 CHEMBL1997764 pKi 199.53 nM
CN1CCN(c2ccc(-c3cnc4c(c3)N(Cc3c(F)ccc(F)c3Cl)CCN4)cn2)CC1 CHEMBL1164265 pKi 199.53 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1ccc(Cl)cc1 CHEMBL1998829 pKi 199.53 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 199.53 nM
CC(Nc1nccc(-c2c(-c3ccc(F)cc3)nc3occn23)n1)c1ccccc1 CHEMBL1990288 pKi 199.53 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 199.53 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 199.53 nM
CC(C)(CO)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)nn12 CHEMBL1972849 pKi 199.53 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 199.53 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 202.0 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccccc5)c4)ccnc3c2)cn1 CHEMBL4877947 IC50 218.26 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1 CHEMBL3991932 Kd apparent 222.0 nM
N#Cc1cccc(-c2ccc3ncnc(N)c3c2)c1 CHEMBL3262575 IC50 225.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 Kd apparent 230.0 nM
COc1ncc(-c2cc(-c3ccc(C(=O)O)cc3)cnc2N)cn1 CHEMBL4743812 IC50 238.0 nM
[2H]C([2H])(O)[C@@H](Nc1nc(Nc2ccc3c(c2)C(C)(C)NC3=O)ncc1-c1nnco1)c1ccc(F)cc1 CHEMBL5396594 IC50 245.9 nM
NC(=O)c1ccc(-n2cc(-c3ccc(Cl)cc3)cn2)cc1 CHEMBL3754611 IC50 248.0 nM
Cc1nc2ccc(NS(=O)(=O)c3ccc(N)cc3)cc2nc1C CHEMBL2006263 pKi 251.19 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 251.19 nM
CC(C)(C)Oc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2002456 pKi 251.19 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 251.19 nM
CC(C)Oc1ccc(-c2noc(-c3ccc(NC4CCC(C(=O)O)C4)cc3)n2)cc1Cl CHEMBL1997503 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 251.19 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 251.19 nM
CCCCOc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1996447 pKi 251.19 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 251.19 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 251.19 nM
Fc1ccc(-c2nc3cnccn3c2-c2ccnc(NCC3CC3)n2)cc1 CHEMBL1990904 pKi 251.19 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 251.19 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 251.19 nM
Oc1ccc(Nc2[nH]nc(-c3ccc(O)cc3)c2-c2ccc(O)cc2)cc1 CHEMBL1969042 pKi 251.19 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 251.19 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 251.19 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=O)s3)c2cc1OC CHEMBL514499 pKi 251.19 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 251.19 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 260.0 nM
Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(C(N)=O)cc24)CCC3)n1 CHEMBL2364611 IC50 263.15 nM
NC(=O)c1ccc(-c2cn(-c3ccc(Cl)cc3)cn2)cc1 CHEMBL3753891 IC50 270.0 nM
CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc21 CHEMBL4748154 IC50 275.6 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 280.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 282.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccccc5)c4)ccnc3c2)cc1 CHEMBL4877481 IC50 291.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 Kd apparent 293.0 nM
Nc1ncnc2ccc(-c3ccccc3F)cc12 CHEMBL3262581 IC50 297.0 nM
NC(=O)c1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326745 IC50 300.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 Kd apparent 307.0 nM
OC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1993584 pKi 316.23 nM
OCCNc1cc2cc(-c3cccnc3)ccc2cn1 CHEMBL1990912 pKi 316.23 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 pKi 316.23 nM
NC(=O)c1sc2c(Br)ccc(Cl)c2c1N CHEMBL1998611 pKi 316.23 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 316.23 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 316.23 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 316.23 nM
CCCCNc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1983157 pKi 316.23 nM
Nc1ccc(-c2csc3c(C=Cc4nc5ccccc5[nH]4)cnc(N)c23)cc1 CHEMBL1988300 pKi 316.23 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 316.23 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 316.23 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 316.23 nM
N#CC1=C(N)n2c(sc(=Cc3ccco3)c2=O)=C(C(N)=O)C1c1ccco1 CHEMBL1989805 pKi 316.23 nM
CC(C)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4n3CCC4)nn12 CHEMBL1977374 pKi 316.23 nM
CN(C)CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1995712 pKi 316.23 nM
N#Cc1ccc2c(c1)C(c1ccc3c(n1)CCCC3O)C(=O)N2 CHEMBL1985681 pKi 316.23 nM
NC(=O)c1ccc(NC2CCCCC2N)nc1Nc1cccc(Cl)c1 CHEMBL1982753 pKi 316.23 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 316.23 nM
Cn1cc(C=C2C(=O)Nc3cccnc32)c2ccccc21 CHEMBL1516890 pKi 316.23 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4sc(C)nc4c3)csc12 CHEMBL1968590 pKi 316.23 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 316.23 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 330.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 330.0 nM
COc1cccc(-c2ccc3ncnc(N)c3c2)c1 CHEMBL3262572 IC50 330.0 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 350.0 nM
Nc1ccc(F)c(-c2ccc3ncnc(N)c3c2)c1 CHEMBL3262578 IC50 351.0 nM
Cc1ccccc1-c1cc(Nc2ccnc3cc(-c4ccc(S(C)(=O)=O)cc4)ccc23)ccn1 CHEMBL4874893 IC50 358.44 nM
Nc1ncnc2ccc(-c3ccc(F)cc3)cc12 CHEMBL3262582 IC50 381.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccoc5)c4)ccnc3c2)cc1 CHEMBL4872884 IC50 384.35 nM
Nc1cc(-c2ccc3ncnc(N)c3c2)ccc1F CHEMBL3262577 IC50 387.0 nM
NC(=O)c1cc(Cl)cc2[nH]c(-c3ccc(C4CCCNC4)cc3F)nc12 CHEMBL1984788 pKi 398.11 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 398.11 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 398.11 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 398.11 nM
Fc1ccc(-c2ncn(CCN3CCOCC3)c2-c2ccc3[nH]ncc3c2)cc1 CHEMBL1682558 pKi 398.11 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 398.11 nM
OCCNc1cc2cc(-c3ccsc3)ccc2cn1 CHEMBL1973860 pKi 398.11 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 398.11 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 398.11 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 398.11 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 398.11 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 398.11 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 pKi 398.11 nM
CC(C)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)nn12 CHEMBL1988995 pKi 398.11 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)c1 CHEMBL185569 pKi 398.11 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 398.11 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 398.11 nM
CCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1979516 pKi 398.11 nM
CCCCn1c(NC(=O)c2cccc(C#N)c2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL1969301 pKi 398.11 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 398.11 nM
Nc1ncc(C(=O)NC2CNC2)c2ccc(-c3cccc(F)c3)cc12 CHEMBL3623132 IC50 401.0 nM
O=C(Nc1ccc(CN2CCN(c3ccccc3)CC2)cc1)c1n[nH]c2ccccc12 CHEMBL3792850 IC50 410.0 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccsc5)c4)ccnc3c2)cn1 CHEMBL4875547 IC50 417.45 nM
Cc1cccc(-c2ccc3ncnc(N)c3c2)c1 CHEMBL3262574 IC50 423.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccc(F)cc5)c4)ccnc3c2)cc1 CHEMBL4853591 IC50 462.86 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cccc12 CHEMBL1975647 pKi 501.19 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 501.19 nM
Cc1ccnc(Nc2cc(C)nc(-c3ccccc3)n2)c1 CHEMBL1985367 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 501.19 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 501.19 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 501.19 nM
N#Cc1cnc(NC(=O)Nc2ccc3cc(C(=O)O)ccc3c2)cn1 CHEMBL560813 pKi 501.19 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 501.19 nM
Cc1cc(-c2ccccc2)n(-c2cc(NN=Cc3ccco3)ncn2)n1 CHEMBL1999590 pKi 501.19 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 501.19 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 501.19 nM
N#Cc1ncc2nc1OCCCCCOc1cc(CCCO)c(Cl)cc1NC(=O)N2 CHEMBL223367 pKi 501.19 nM
COc1ccc(-c2cnc3c(Br)cnn3c2)cc1 CHEMBL443962 pKi 501.19 nM
COc1ccc(C=C2SC(=Nc3ccccc3)NC2=O)cc1O CHEMBL2000354 pKi 501.19 nM
COc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC CHEMBL1974664 pKi 501.19 nM
CC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL2000568 pKi 501.19 nM
CC(C)(O)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4n3CCC4)nn12 CHEMBL1998551 pKi 501.19 nM
CCN(CC)CC#Cc1ccc2c(c1)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL2007044 pKi 501.19 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 501.19 nM
c1ccc(Nc2nc(-c3ccc4[nH]ncc4c3)cs2)cc1 CHEMBL1682545 pKi 501.19 nM
Nc1n[nH]c2ccc(-c3cc(Cc4ccccc4)no3)cc12 CHEMBL1682358 pKi 501.19 nM
Nc1ncnc(Nc2cc(CNC(=O)C(F)(F)F)c(O)c(-c3ccc(Cl)cc3)c2)n1 CHEMBL2001239 pKi 501.19 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ncccn2)CC1 CHEMBL1986530 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 501.19 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1966514 pKi 501.19 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 501.19 nM
Cc1cccc(-c2cc(Nc3ccnc4cc(-c5cnn(CCN(C)C)c5)ccc34)ccn2)c1 CHEMBL4858177 IC50 517.54 nM
COc1ccccc1-c1ccc2ncnc(N)c2c1 CHEMBL3262571 IC50 546.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 590.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1 CHEMBL3989914 Kd apparent 600.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 630.96 nM
CCC1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL1968380 pKi 630.96 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 630.96 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 630.96 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCNC4)cc3F)nc12 CHEMBL1997025 pKi 630.96 nM
NC(COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL1967302 pKi 630.96 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 630.96 nM
Cc1nccn2c(-c3ccnc(NCCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1978200 pKi 630.96 nM
C=CCc1cccc2c(=NO)cc(-c3ccccc3)oc12 CHEMBL1977749 pKi 630.96 nM
CC(C)NC1=NNC(=O)C1=Cc1cc2ccccc2[nH]1 CHEMBL1988692 pKi 630.96 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 630.96 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 630.96 nM
O=C1NC(=S)SC1=C1C(=O)Nc2ccc(Br)cc21 CHEMBL2001920 pKi 630.96 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 630.96 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 630.96 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 630.96 nM
NC(=O)c1cccc2[nH]c(-c3ccc(NC(=O)c4cccc(S(=O)(=O)N5CCOCC5)c4)cc3)nc12 CHEMBL1986597 pKi 630.96 nM
CC(C)(O)Cc1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)nn12 CHEMBL1976732 pKi 630.96 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1 CHEMBL526133 pKi 630.96 nM
CCOC(=O)c1ccc2[nH]c3c(c2c1)CCNC3=O CHEMBL2005528 pKi 630.96 nM
Fc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL316264 pKi 630.96 nM
Clc1ccc(-c2n[nH]cc2-c2ccncn2)cc1Cl CHEMBL1984191 pKi 630.96 nM
Cc1nnc(-c2cc3c(Oc4ccc(C(F)(F)F)cc4)cncc3s2)o1 CHEMBL1988153 pKi 630.96 nM
O=[N+]([O-])c1cccc(-c2nnc3ccc(N4CCCCC4)nn23)c1 CHEMBL2003637 pKi 630.96 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 630.96 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 630.96 nM
O=C(O)c1ccccc1Nc1ccnc(NCc2cccc(O)c2)n1 CHEMBL1970950 pKi 630.96 nM
O=C(Nc1cccc(F)c1)Nc1cccc(-c2ccc3cn[nH]c3c2)c1 CHEMBL1983393 pKi 630.96 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 630.96 nM
CSc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL17370 pKi 630.96 nM
CCNC(=O)c1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326746 IC50 640.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 650.0 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O CHEMBL4475494 IC50 680.0 nM
COc1ccc(-c2ccc3ncnc(N)c3c2)cc1 CHEMBL3262573 IC50 689.0 nM
N#Cc1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326741 IC50 710.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cc1 CHEMBL4861887 IC50 747.88 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5cccc(F)c5)c4)ccnc3c2)cn1 CHEMBL4872045 IC50 756.53 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3F)ccc21 CHEMBL1989293 pKi 794.33 nM
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12 CHEMBL1973142 pKi 794.33 nM
CN(C)CCCOc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1988662 pKi 794.33 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 794.33 nM
Cc1cc(-c2ccc3c(c2)Nc2ccccc2NC3=O)ccn1 CHEMBL1981511 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 794.33 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 794.33 nM
S=c1[nH]nc2c3c4c(sc3n3c(=S)[nH]nc3n12)CCC4 CHEMBL1969537 pKi 794.33 nM
CC(N)COc1cnc(Cl)c(C=Cc2ccncc2)c1 CHEMBL1993548 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 794.33 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 794.33 nM
CCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998470 pKi 794.33 nM
COc1ccccc1-c1ccnc(Nc2cccc(S(C)(=O)=O)c2)n1 CHEMBL1975903 pKi 794.33 nM
O=c1[nH]cnc2c1sc1c(Cl)ccc(Cl)c12 CHEMBL583144 pKi 794.33 nM
NC(=O)c1sc2ccc(Cl)c(Cl)c2c1NC(=O)c1ccc(Cl)cc1 CHEMBL2003271 pKi 794.33 nM
O=C(NCCc1cccs1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1987535 pKi 794.33 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 794.33 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL274064 pKi 794.33 nM
OCCNc1cc2cc(-c3ccccc3)ccc2cn1 CHEMBL1989957 pKi 794.33 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 794.33 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2-c2ccccc2)cc1 CHEMBL1969473 pKi 794.33 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOCC5CC5)c4)n[nH]c2-3)CC1 CHEMBL2002446 pKi 794.33 nM
Nc1ncnc2c1N=C(c1ccccc1)CCN2 CHEMBL262623 pKi 794.33 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 794.33 nM
Clc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1972988 pKi 794.33 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3Cl)ccc21 CHEMBL1987745 pKi 794.33 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3[nH]2)cc1 CHEMBL1979057 pKi 794.33 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 794.33 nM
NCCNS(=O)(=O)c1cccc(C(=O)Nc2ccc(-c3n[nH]c(=O)c4ccccc34)cc2)c1 CHEMBL2000481 pKi 794.33 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1995832 pKi 794.33 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL95692 pKi 794.33 nM
c1ccc(CNc2nc3ccc(-c4ccncc4)cc3s2)cc1 CHEMBL1983534 pKi 794.33 nM
OCCC(Nc1nc2ccc(-c3ccncc3)cc2s1)c1ccccc1 CHEMBL1982122 pKi 794.33 nM
COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1 CHEMBL3263773 IC50 820.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 832.0 nM
CC(C)(O)c1cc2c(Nc3ccncc3)ncnn2c1 CHEMBL3326744 IC50 840.0 nM
NC(=O)c1ccc(-c2nccc(-c3ccc(Cl)cc3)n2)cc1 CHEMBL3754522 IC50 861.0 nM
CN1Cc2nccc(-c3cn(C)nc3-c3ccc(F)cc3)c2C1=O CHEMBL5303425 IC50 873.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 880.0 nM
C[C@@H](N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1 CHEMBL571948 Kd apparent 946.0 nM
COc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1980435 pKi 1000.0 nM
CSc1c[nH]c2ncnc(NCCCO)c12 CHEMBL2000114 pKi 1000.0 nM
CN(C)c1ccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)cc1 CHEMBL1984367 pKi 1000.0 nM
NC(COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1987679 pKi 1000.0 nM
Oc1cnc2ccc(-c3ccncc3)cc2c1 CHEMBL1973868 pKi 1000.0 nM
CCN(CC)CCOc1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1984044 pKi 1000.0 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 1000.0 nM
COc1cc(C=C2SC(=Nc3ccccc3)NC2=O)ccc1O CHEMBL1970522 pKi 1000.0 nM
CCOC(=O)C1=C(N)n2c(sc(=Cc3cccs3)c2=O)=C(C(N)=O)C1c1cccs1 CHEMBL2004365 pKi 1000.0 nM
Oc1ccc(-c2n[nH]c(Nc3cccc(Cl)c3)c2-c2ccc(O)cc2)cc1 CHEMBL1985092 pKi 1000.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 pKi 1000.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 1000.0 nM
O=C(Nc1ccc2[nH]ncc2c1)c1ccc(Cl)cc1 CHEMBL1973808 pKi 1000.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL2004631 pKi 1000.0 nM
NCC1CCC(CNc2nc(NCc3ccccc3Cl)ncc2[N+](=O)[O-])CC1 CHEMBL246970 pKi 1000.0 nM
O=C(CO)N1CCC(c2[nH]nc(-c3ccc(Cl)cc3F)c2-c2ccncn2)CC1 CHEMBL1614705 pKi 1000.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 pKi 1000.0 nM
NC(=O)c1cccc2[nH]c(-c3ccncc3)nc12 CHEMBL1990482 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 1000.0 nM
O=C(Cc1ccc(-c2cccnc2)cc1)Nc1ccc(SC(F)F)cc1 CHEMBL1992581 pKi 1000.0 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 1000.0 nM
Oc1ccc(Nc2nc(-c3ccc(Cl)cc3)cs2)cc1 CHEMBL1076555 pKi 1000.0 nM
CN1CCN(c2ccc(-c3cc4c(Nc5ccncc5)ncnn4c3)cc2)CC1 CHEMBL3326764 IC50 1000.0 nM
CN(C)Cc1ccc(-c2cc3c(Nc4ccncc4)ncnn3c2)cc1 CHEMBL3326760 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM