Nc1ncc([C@@H]2CC[C@@H](O)[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4115001 IC50 0.00431 nM
NC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@H](F)C3)cnc2N)cc1F)c1cc(F)cc(I)c1 CHEMBL4111166 IC50 0.005 nM
Nc1ncc([C@H]2CC[C@H](O)[C@@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3904235 IC50 0.0055 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(I)c1 CHEMBL3980387 IC50 0.00612 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cc(F)cc(I)c1 CHEMBL4107592 IC50 0.00665 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL3895057 IC50 0.00671 nM
CSc1cc(F)cc([C@@H](CO)NC(=O)c2ccc(-c3nc(C4CCOCC4)cnc3N)cc2F)c1 CHEMBL4114093 IC50 0.00827 nM
NC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cc(F)cc(I)c1 CHEMBL4108056 IC50 0.00837 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(CF)c4)c(F)c3)c2)cnn1C CHEMBL4110872 IC50 0.00875 nM
Nc1ncc([C@@H]2CCC(=O)NC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4115419 IC50 0.009 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4111422 IC50 0.0097 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4111944 IC50 0.00977 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)cn2CCCN1[C@H](CO)c1cccc(Cl)c1 CHEMBL3608588 IC50 0.01 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(CF)c2)c(F)c1 CHEMBL4114147 IC50 0.01 nM
CSc1cccc([C@@H](CO)NC(=O)c2ccc(-c3nc(C4CCOCC4)cnc3N)cc2F)c1 CHEMBL4108345 IC50 0.01 nM
NC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@@H](F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4109252 IC50 0.0103 nM
Cc1nn(C(F)F)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(CF)c3)c(F)c2)c1 CHEMBL3957670 IC50 0.0104 nM
CO[C@H]1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CN)c4cc(F)cc(I)c4)c(F)c3)n2)CC1 CHEMBL4107945 IC50 0.0107 nM
NC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(I)c1 CHEMBL4109456 IC50 0.011 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(Cl)c1 CHEMBL3923033 IC50 0.0119 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(CF)c3)c(F)c2)c1 CHEMBL4110508 IC50 0.0121 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4108076 IC50 0.0127 nM
Nc1ncc([C@H]2CC[C@H](O)[C@@H](F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3956128 IC50 0.0139 nM
NC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@H](F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4107980 IC50 0.0139 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(CF)c4)c(F)c3)c2)cnn1C(F)F CHEMBL4109206 IC50 0.014 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(Cl)c1 CHEMBL4115307 IC50 0.0143 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)[C@@H](F)C3)cnc2N)cc1F)c1cc(F)cc(I)c1 CHEMBL3923915 IC50 0.0143 nM
CSc1cc(F)cc([C@@H](CO)NC(=O)c2ccc(-c3nc(-c4cn(C)nc4C)cnc3N)cc2F)c1 CHEMBL4109955 IC50 0.0153 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(I)c3)c(F)c2)c1 CHEMBL4106909 IC50 0.0158 nM
Cc1nn(C(F)F)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(CF)c3)c(F)c2)c1 CHEMBL4113157 IC50 0.0168 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4107833 IC50 0.0173 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(I)c2)c(F)c1 CHEMBL4114947 IC50 0.0175 nM
Nc1ncc([C@@H]2CC[C@@H](O)[C@H](F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3913471 IC50 0.0176 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4108962 IC50 0.0183 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)cnn1C CHEMBL3905175 IC50 0.0187 nM
Nc1ncc([C@@H]2CC[C@@H](O)[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4114300 IC50 0.0187 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)cn2CCCN1[C@H](CO)c1cc(F)cc(Cl)c1 CHEMBL3608589 IC50 0.019 nM
NC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)[C@H](F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL3930522 IC50 0.0194 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(CF)c2)c(F)c1 CHEMBL4106814 IC50 0.0197 nM
CSc1cc(F)cc([C@@H](CO)NC(=O)c2ccc(-c3nc([C@H]4CC[C@H](O)CC4)cnc3N)cc2F)c1 CHEMBL4114593 IC50 0.0198 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(CF)c4)c(F)c3)c2)cn1 CHEMBL4113452 IC50 0.0199 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4108313 IC50 0.02 nM
CC(=O)NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4108926 IC50 0.0201 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@H](F)C3)cnc2N)cc1F)c1cc(F)cc(I)c1 CHEMBL4115371 IC50 0.0205 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](OC)CC3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4108747 IC50 0.0205 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(CF)c4)c(F)c3)c2)cnn1C(F)F CHEMBL4113751 IC50 0.0208 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(C(F)F)c2)c(F)c1 CHEMBL4113025 IC50 0.0208 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4110468 IC50 0.0208 nM
Cn1nccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CN)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4107676 IC50 0.0209 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4112962 IC50 0.0209 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL3928081 IC50 0.021 nM
Nc1ncc(C2CCC(O)CC2)nc1-c1ccc(C(=O)N[C@@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3924033 IC50 0.0217 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Cl)c2)c(F)c1 CHEMBL4112079 IC50 0.0222 nM
Nc1ncc(C2CCC(O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(CF)c2)c(F)c1 CHEMBL3891114 IC50 0.0229 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@@H](F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4108968 IC50 0.023 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(CCl)c2)c(F)c1 CHEMBL4108246 IC50 0.0242 nM
Cc1nn(C(F)F)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4106578 IC50 0.0245 nM
CCNC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4113613 IC50 0.0248 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4106790 IC50 0.0252 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(CF)c4)c(F)c3)c2)cnn1C CHEMBL4114268 IC50 0.0258 nM
O=C1c2cc(-c3ccnc(N[C@H]4[C@@H]5COC[C@@H]54)n3)cn2CCCN1[C@H](CO)c1cccc(Cl)c1 CHEMBL3608586 IC50 0.026 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)[C@@H](F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL3909517 IC50 0.0261 nM
Nc1ncc([C@@H]2CC[C@@H](O)C(F)(F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4110204 IC50 0.0261 nM
Cc1cccc([C@@H](CO)NC(=O)c2ccc(-c3nc(C4CCOCC4)cnc3N)cc2F)c1 CHEMBL4114445 IC50 0.0263 nM
CSc1cccc([C@@H](CO)NC(=O)c2ccc(-c3nc([C@H]4CC[C@H](O)CC4)cnc3N)cc2F)c1 CHEMBL4106863 IC50 0.0269 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL3919189 IC50 0.0282 nM
Nc1ncc(C2CCC(O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3932226 IC50 0.0285 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(CF)c3)c(F)c2)c1 CHEMBL4107705 IC50 0.0287 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CCC[C@@H](O)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL3901227 IC50 0.0291 nM
CC(C)Nc1cc(-c2c[nH]c(C(=O)N[C@H](CO)c3cccc(Cl)c3)c2)c(Cl)cn1 CHEMBL3590106 IC50 0.03 nM
CCNC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4114349 IC50 0.03 nM
Nc1ncc([C@H]2CC[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3923999 IC50 0.03 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(C(F)F)c4)c(F)c3)c2)cnn1C CHEMBL4114641 IC50 0.0308 nM
Nc1ncc(C2CCCC(O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Br)c2)c(F)c1 CHEMBL4108154 IC50 0.0308 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(Br)c3)c(F)c2)c1 CHEMBL4107068 IC50 0.031 nM
Cc1nn(C(F)F)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(C(F)F)c3)c(F)c2)c1 CHEMBL4109712 IC50 0.0312 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)[C@H](F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL3970217 IC50 0.0317 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)cn2CCCN1[C@H](CO)c1ccccc1 CHEMBL3608462 IC50 0.033 nM
Nc1ncc(C2CCCC(O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4111888 IC50 0.0333 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Br)c2)c(F)c1 CHEMBL4109708 IC50 0.0343 nM
CS(=O)(=O)c1cccc([C@@H](CO)NC(=O)c2ccc(-c3nc(C4CCOCC4)cnc3N)cc2F)c1 CHEMBL4114358 IC50 0.0345 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4F)n3)cn2CCCN1[C@H](CO)c1cccc(Cl)c1 CHEMBL3608464 IC50 0.035 nM
Nc1ncc(C2CCC(=O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4108238 IC50 0.036 nM
Nc1ncc([C@@H]2CC[C@@H](O)[C@@H](F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3946329 IC50 0.0363 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CN)c4cccc(Cl)c4)c(F)c3)c2)cnn1C CHEMBL4113846 IC50 0.0364 nM
Cc1nn(C)c(C)c1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CN)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4111641 IC50 0.0364 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(C(F)F)c4)c(F)c3)c2)cnn1C CHEMBL4115643 IC50 0.0371 nM
Cc1cccc([C@@H](CO)NC(=O)c2ccc(-c3cc(-c4cn(C)nc4C)cnc3N)cc2F)c1 CHEMBL4113197 IC50 0.0378 nM
Nc1ncc([C@H]2CCC(=O)NC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3967502 IC50 0.039 nM
COC1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CN)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL3948885 IC50 0.0396 nM
Nc1ncc([C@H]2CC[C@H](O)C(F)(F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3971970 IC50 0.0397 nM
O=C1c2cc(-c3ccnc(NC4CC5(COC5)C4)n3)cn2CCCN1[C@H](CO)c1ccccc1 CHEMBL3608463 IC50 0.04 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCC(F)(F)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL3982225 IC50 0.04 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCCC(O)C3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4111789 IC50 0.04 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](OC)CC3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4112935 IC50 0.0401 nM
Nc1ncc([C@@H]2CC[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4113389 IC50 0.0403 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4115558 IC50 0.041 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)cnn1C(F)F CHEMBL4110779 IC50 0.0431 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(C(F)F)c2)c(F)c1 CHEMBL4112519 IC50 0.0435 nM
N#CC1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(Br)c4)c(F)c3)n2)CC1 CHEMBL4112993 IC50 0.0442 nM
Nc1ncc([C@H]2CC[C@H](O)[C@@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3910107 IC50 0.0446 nM
NC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4107391 IC50 0.0452 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4112340 IC50 0.0463 nM
Nc1ncc(C2CCC(CO)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4113430 IC50 0.0464 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(C(F)F)c3)c(F)c2)c1 CHEMBL4112506 IC50 0.0467 nM
Nc1ncc(C2CCC(O)C(F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3928896 IC50 0.0469 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(C(F)F)c4)c(F)c3)c2)cnn1C(F)F CHEMBL4113849 IC50 0.0482 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Br)c2)c(F)c1 CHEMBL4112430 IC50 0.0485 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Br)c3)c(F)c2)c1 CHEMBL4113172 IC50 0.0487 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CN)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4111410 IC50 0.0497 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)cn2C[C@@H](F)CN1[C@H](CO)c1cccc(Cl)c1 CHEMBL3608587 IC50 0.05 nM
COC[C@H]1Cn2cc(-c3nc(Nc4ccnn4C)ncc3C)nc2C(=O)N1Cc1ccc(F)c(F)c1 CHEMBL4482864 pKd 0.05012 nM
O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)[C@@H]1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL3590107 pKd 0.05012 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCCCC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4115289 IC50 0.0505 nM
Nc1ncc([C@H]2CC[C@H](O)[C@@H](F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3900490 IC50 0.051 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(Cl)c3)c(F)c2)c1 CHEMBL4113136 IC50 0.0547 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CCC[C@H](O)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4111913 IC50 0.0557 nM
COC(=O)N[C@H]1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(Br)c4)c(F)c3)n2)CC1 CHEMBL4108498 IC50 0.0559 nM
Nc1ncc([C@@H]2CC[C@@H](O)[C@H](F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3931978 IC50 0.0571 nM
Nc1ncc([C@@H]2CC[C@@H](O)C(F)(F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4108402 IC50 0.0581 nM
Cn1nccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(CF)c3)c(F)c2)c1 CHEMBL4109328 IC50 0.0599 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)n1 CHEMBL3948642 IC50 0.0604 nM
C[C@@H](NC(=O)c1ccc(-c2nc(C3CCCCC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4107587 IC50 0.0614 nM
CCNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4110654 IC50 0.0617 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(C(F)F)c3)c(F)c2)c1 CHEMBL4115387 IC50 0.0619 nM
Cn1nccc1Nc1nccc(-c2cc3c(s2)C(C)(C)N(CCN2CCOCC2)C3=O)n1 CHEMBL4650285 Ki 0.064 nM
C[C@@H](O)[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4114038 IC50 0.0645 nM
Nc1ncc(C2CCCCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4106511 IC50 0.0651 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4109307 IC50 0.0655 nM
Nc1ncc([C@@H]2CC[C@@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4111125 IC50 0.0684 nM
CO[C@H]1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CN)c4cccc(Br)c4)c(F)c3)n2)CC1 CHEMBL4108368 IC50 0.0689 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](OC)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4111042 IC50 0.07 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)cc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4107018 IC50 0.0701 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(C(F)F)c3)c(F)c2)c1 CHEMBL4108955 IC50 0.0707 nM
CC(=O)N1CCC(=NNc2nc3ccccc3s2)CC1 CHEMBL1391281 Potency 0.0708 nM
CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)cn1 CHEMBL4110638 IC50 0.0715 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CNCCF)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4109474 IC50 0.0743 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(C(F)F)c4)c(F)c3)c2)cnn1C(F)F CHEMBL4112865 IC50 0.0745 nM
Nc1ncc(C2CCCC(O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4113682 IC50 0.0752 nM
Nc1ncc(C2=CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4106675 IC50 0.0759 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@H](F)C3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4108572 IC50 0.076 nM
COCCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)cn1 CHEMBL4115538 IC50 0.0785 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(Cl)c4)c(F)c3)c2)cn1 CHEMBL4111998 IC50 0.0814 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)C(F)(F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL3895902 IC50 0.0823 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H]2C[C@@H]2c2ccccc2)c(F)c1 CHEMBL3949051 IC50 0.0842 nM
Nc1ncc([C@H]2CC[C@H](O)C(F)(F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3938437 IC50 0.0872 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)NC(CN)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL3894824 IC50 0.0901 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)cn1 CHEMBL4109063 IC50 0.0923 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4112789 IC50 0.0928 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(C(F)F)c3)c(F)c2)c1 CHEMBL4109028 IC50 0.0933 nM
Cn1ccc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)n1 CHEMBL4114979 IC50 0.0937 nM
COC(=O)NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4110708 IC50 0.0943 nM
CS(=O)(=O)NC1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL3927870 IC50 0.0955 nM
Nc1ncc([C@H]2CC[C@@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4112411 IC50 0.0956 nM
Cc1cccc(N2C(=O)/C(=C/Nc3ccc4c(c3)OCO4)c3ccccc3C2=O)n1 CHEMBL1505151 Potency 0.1 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccc(Cl)cc1 CHEMBL3409573 Ki 0.1 nM
COc1cccc(C(CO)n2ccc(-c3ccnc(NC4CCOCC4)n3)cc2=O)c1 CHEMBL3409578 Ki 0.1 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1cc(F)cc(Cl)c1 CHEMBL3409585 Ki 0.1 nM
O=c1cc(-c2nc(NC3CCOCC3)ncc2F)ccn1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409600 Ki 0.1 nM
COC(=O)NC1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL3899872 IC50 0.102 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc([C@@H]3CC[C@@H](O)[C@H](F)C3)cnc2N)cc1F)c1cc(F)cc(Br)c1 CHEMBL4111409 IC50 0.104 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(C(F)F)c2)c(F)c1 CHEMBL4108467 IC50 0.105 nM
Nc1ncc(C2CCC(F)(F)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4109811 IC50 0.105 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(C(F)F)c4)c(F)c3)c2)cn1 CHEMBL4115079 IC50 0.106 nM
[N-]=[N+]=NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4112181 IC50 0.115 nM
CNC[C@@H](NC(=O)c1ccc(-c2nc(C3CCCC(O)C3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4111399 IC50 0.127 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)CCN(Cc1cccc(Cl)c1)C2=O CHEMBL4470113 IC50 0.13 nM
Nc1ncc([C@@H]2CC[C@H](O)[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL4111305 IC50 0.135 nM
Cc1cc(-c2nc(C3CCOCC3)cnc2N)ccc1C(=O)N[C@H](CO)c1ccccc1 CHEMBL4106860 IC50 0.136 nM
CO[C@H]1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(Br)c4)c(F)c3)n2)C[C@@H]1O CHEMBL3957062 IC50 0.136 nM
Nc1ncc([C@H]2CC[C@@H](O)[C@@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3955555 IC50 0.137 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccc(F)c(Cl)c2)c(F)c1 CHEMBL4113895 IC50 0.139 nM
Nc1ncc([C@H]2CC[C@@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1 CHEMBL3967985 IC50 0.144 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](C)c4cc(F)cc(S(C)(=O)=O)c4)c(F)c3)c2)cnn1C(F)F CHEMBL4111507 IC50 0.146 nM
Cc1cc(-c2cc(-c3cnnn3C)cnc2N)ccc1C(=O)N[C@H](CO)c1cccc(Cl)c1 CHEMBL4111635 IC50 0.149 nM
O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3298678 Ki 0.15 nM
Nc1ncc(C2CCC(O)CC2)nc1-c1ccc(C(=O)N[C@H]2C[C@@H]2c2ccccc2)c(F)c1 CHEMBL3943715 IC50 0.152 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](CN)c4ccccc4)ncc23)ccn1 CHEMBL3658845 IC50 0.1524 nM
Cc1cccc(CN2C(=O)c3cc(-c4nc(Nc5ccnn5C)ncc4C)cn3C[C@H]2C)n1 CHEMBL4071576 pKd 0.1585 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(=O)n(C)c3)c2cn1)c1ccc(F)cc1 CHEMBL3654722 IC50 0.1588 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc(S(C)(=O)=O)c4)ncc23)ccn1 CHEMBL3663068 IC50 0.1591 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)cn2CCN1[C@H](CO)c1cccc(Cl)c1 CHEMBL3608591 IC50 0.16 nM
Nc1ncc(-c2ccncc2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4109681 IC50 0.163 nM
O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)nc2n1 CHEMBL5428299 Ki 0.17 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CN(C)C[C@H]4c4ccccc4F)ncc23)ccn1 CHEMBL3654812 IC50 0.1709 nM
Nc1ncc([C@@H]2CCC(F)(F)[C@@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4114471 IC50 0.179 nM
Cn1nncc1-c1cnc(N)c(-c2cc(F)c(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4114294 IC50 0.183 nM
COC[C@@H](NC(=O)Nc1ncc2c(-c3ccncc3)n[nH]c2c1F)c1ccccc1 CHEMBL3663002 IC50 0.1837 nM
Nc1ncc([C@H]2CC[C@H](F)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4112282 IC50 0.184 nM
O=C1c2cc(-c3ccnc(N[C@@H]4C[C@H](O)[C@@H](F)C4)n3)cn2CCCN1[C@H](CO)c1ccccc1 CHEMBL3608458 IC50 0.19 nM
O=C1c2cc(-c3ccnc(N[C@H]4CC[C@@H](O)C4)n3)cn2CCCN1[C@H](CO)c1cccc(Cl)c1 CHEMBL3608461 IC50 0.19 nM
Nc1ncc([C@H]2CC[C@@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(I)c2)c(F)c1 CHEMBL4112672 IC50 0.193 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4COC[C@H]4c4ccccc4)ncc23)ccn1 CHEMBL3663034 IC50 0.1934 nM
NC(=O)CC1NC(=O)c2ccccc21 CHEMBL1517449 Potency 0.2 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1cc(Cl)cc(Cl)c1 CHEMBL3409584 Ki 0.2 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1[C@H](CO)c1cccc(F)c1 CHEMBL3409587 Ki 0.2 nM
O=c1cc(-c2nc(NC3CCOCC3)ncc2Cl)ccn1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409599 Ki 0.2 nM
O=c1cc(N2CCc3[nH]nc(-c4ccncc4)c3C2)ccn1Cc1cccc(Br)c1 CHEMBL3604851 IC50 0.2 nM
CN1C[C@H](c2ccccc2)[C@H](NC(=O)Nc2cc3[nH]nc(N4CCOCC4)c3cn2)C1 CHEMBL4111821 IC50 0.2 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccc(F)cc1 CHEMBL4109364 IC50 0.2 nM
C[C@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccc(F)cc1 CHEMBL3985624 IC50 0.2 nM
Cn1cc2c(n1)CCN(c1n[nH]c3cc(NC(=O)N[C@@H](c4ccc(F)cc4)C(C)(C)O)ncc13)C2 CHEMBL3967428 IC50 0.2 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)NC(CN)c4cccc(Cl)c4)c(F)c3)c2)cn1 CHEMBL3939292 IC50 0.2 nM
COCCN1C(=O)c2cc(-c3nc(Nc4ccnn4C)ncc3C)cn2C[C@H]1C CHEMBL4086507 IC50 0.2 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)ccn1 CHEMBL2408789 IC50 0.2 nM
Nc1ncc(-c2ccncc2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4111855 IC50 0.201 nM
Nc1ncc(C2CCC(CO)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4106965 IC50 0.215 nM
Cc1cccc([C@@H](CO)NC(=O)c2ccc(-c3cc(-c4ccnn4C)cnc3N)cc2F)c1 CHEMBL4107341 IC50 0.217 nM
Nc1ncc(C2CCNC(=O)C2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4109430 IC50 0.217 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CN(C)C[C@H]4c4ccccc4)ncc23)ccn1 CHEMBL3654809 IC50 0.2171 nM
Nc1ncc([C@H]2CC[C@@H](O)[C@@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3946846 IC50 0.218 nM
O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL5399703 Ki 0.22 nM
C[C@@H](NC(=O)c1ccc(-c2cc(-c3cnnn3C)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4115339 IC50 0.221 nM
C[C@@H](NC(=O)c1ccc(-c2nc(C3=CCOCC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4115416 IC50 0.221 nM
Nc1ncc([C@H]2CCC(F)(F)[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3934781 IC50 0.221 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nnn(C)c4c3)c2cn1)c1ccccc1 CHEMBL3663134 IC50 0.2213 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658692 IC50 0.223 nM
Nc1ncc([C@H]2CCC[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3893928 IC50 0.223 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nn(C)cc4c3)c2cn1)c1ccccc1 CHEMBL3663093 IC50 0.2233 nM
COC(=O)NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Br)c1 CHEMBL4112792 IC50 0.225 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CN)c4ccccc4)ncc23)ccn1 CHEMBL3658725 IC50 0.2316 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CN(C)C[C@H]4c4cccc(Cl)c4)ncc23)ccn1 CHEMBL3663035 IC50 0.233 nM
Cc1cc(-c2n[nH]c3c(F)c(NC(=O)N[C@H](C)c4ccccc4)ncc23)ccn1 CHEMBL3654746 IC50 0.2351 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccncc3)c2cn1)c1ccccc1 CHEMBL3663000 IC50 0.2357 nM
CC(=O)NC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4111729 IC50 0.238 nM
CS(=O)(=O)c1cc(F)cc(CNC(=O)c2ccc(-c3nc(C4CCOCC4)cnc3N)cc2F)c1 CHEMBL3896812 IC50 0.242 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc(F)c4)ncc23)ccn1 CHEMBL3654704 IC50 0.2452 nM
CO[C@H]1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CNC(C)=O)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4106946 IC50 0.249 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1)c1ccccc1 CHEMBL3663084 IC50 0.2508 nM
Nc1ncc([C@@H]2CC[C@H](O)[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4108693 IC50 0.251 nM
Cn1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)c(Cl)c4)ncc23)cn1 CHEMBL3654711 IC50 0.2512 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1ccccc1 CHEMBL4112757 IC50 0.253 nM
CSC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1 CHEMBL3663025 IC50 0.2569 nM
Cn1nccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cc(F)cc(Cl)c3)c(F)c2)c1 CHEMBL4108337 IC50 0.257 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H](c4ccccc4)[C@H]4CCCO4)ncc23)ccn1 CHEMBL3663008 IC50 0.2599 nM
O=C1c2cc(-c3ccnc(N[C@@H]4C[C@H](O)C(F)(F)C4)n3)cn2CCCN1[C@H](CO)c1cccc(Cl)c1 CHEMBL3608459 IC50 0.26 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H](c4ccccc4)[C@@H]4CCCO4)ncc23)ccn1 CHEMBL3663009 IC50 0.2616 nM
Cc1cnccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)n1 CHEMBL4112127 IC50 0.265 nM
COC[C@@H](NC(=O)Nc1ncc2c(-c3ccnc(C)c3)n[nH]c2c1F)c1ccccc1 CHEMBL3662997 IC50 0.2688 nM
COC[C@@H](NC(=O)Nc1ncc2c(-c3ccnc(F)c3)n[nH]c2c1F)c1ccccc1 CHEMBL3662998 IC50 0.2724 nM
C[C@@H](O)[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4112345 IC50 0.281 nM
COc1cccc(F)c1CN1CCC[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccnc(C)c4)c3cn2)C1 CHEMBL2408790 IC50 0.2857 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](CO)c4cccc5cc[nH]c45)ncc23)ccn1 CHEMBL3658726 IC50 0.288 nM
Cc1nn(C)c(C)c1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4109037 IC50 0.288 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)cc(C)n1 CHEMBL3654682 IC50 0.2904 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](CN(C)C)c4ccccc4)ncc23)ccn1 CHEMBL3658844 IC50 0.2904 nM
COc1ccccc1CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3662984 IC50 0.2928 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(S(C)(=O)=O)c3)c(F)c2)c1 CHEMBL4112455 IC50 0.296 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nn(C)cc4c3)c2cn1)c1ccccc1 CHEMBL3663062 IC50 0.2974 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1 CHEMBL3662993 IC50 0.2983 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1[C@H](CO)c1ccc(F)c(Cl)c1 CHEMBL3409589 Ki 0.3 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccc(F)c(Cl)c1 CHEMBL3409582 Ki 0.3 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1[C@H](CO)c1cccc(Cl)c1 CHEMBL3409586 Ki 0.3 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1ccc(Cl)cc1 CHEMBL3409408 Ki 0.3 nM
O=c1cc(N2CCc3[nH]nc(-c4ccncc4)c3C2)ccn1Cc1cccc(Cl)c1 CHEMBL3604850 IC50 0.3 nM
Cn1nccc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL3544964 IC50 0.3 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)[C@@H](C)O)nc(CO)c12 CHEMBL4113717 IC50 0.3 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(CO)c12 CHEMBL4110724 IC50 0.3 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2c(CO)n1)c1ccc(F)cc1 CHEMBL3920606 IC50 0.3 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)nc(CO)c12 CHEMBL3971306 IC50 0.3 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)nc(CO)c12 CHEMBL3932591 IC50 0.3 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOC(C)C3)c2cn1)c1ccccc1 CHEMBL4106913 IC50 0.3 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccccc1 CHEMBL4111938 IC50 0.3 nM
Cc1nc(NC(=O)N[C@@H](c2ccccc2)C(C)(C)O)cc2[nH]nc(N3CCOCC3)c12 CHEMBL3974074 IC50 0.3 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2c(CO)n1)c1ccccc1 CHEMBL3965910 IC50 0.3 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4ncsc4C3)c2cn1)c1ccccc1 CHEMBL3968544 IC50 0.3 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4ncsc4C3)c2cn1)c1ccccc1 CHEMBL4109000 IC50 0.3 nM
CC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](COC(F)F)c3ccccc3)ncc12 CHEMBL4109167 IC50 0.3 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H]3c4ccccc4OCC[C@H]3O)ncc12 CHEMBL4111834 IC50 0.3 nM
O=C(Nc1cc2[nH]nc(NC(=O)N3CC(F)(F)C3)c2cn1)N[C@H]1c2ccccc2OCC[C@H]1O CHEMBL4108569 IC50 0.3 nM
CC(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccccc1 CHEMBL4115515 IC50 0.3 nM
Nc1ncc([C@@H]2CCC[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3912072 IC50 0.3 nM
Cc1cccc(CN2CCn3cc(-c4nc(Nc5ccnn5C)ncc4C)cc3C2=O)n1 CHEMBL4101072 IC50 0.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(C)c3)c2cn1)c1ccccc1 CHEMBL3654680 IC50 0.3 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)c(F)c4)ncc23)ccn1 CHEMBL3658776 IC50 0.3033 nM
Cc1cc(-c2n[nH]c3c(F)c(NC(=O)N[C@H](C)c4ccc(F)cc4)ccc23)ccn1 CHEMBL3662990 IC50 0.3036 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(=O)[nH]c3)c2cn1)c1ccc(F)cc1 CHEMBL3658652 IC50 0.3037 nM
COc1cccc(F)c1CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3658847 IC50 0.3067 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccccc4OC(F)F)ncc23)ccn1 CHEMBL3658804 IC50 0.3088 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nnn(C)c4c3)c2cn1)c1ccc(F)cc1 CHEMBL3654886 IC50 0.309 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CS(C)(=O)=O)c4ccccc4)ncc23)ccn1 CHEMBL3663021 IC50 0.3132 nM
O=C(Nc1ncc2c(-c3ccncc3)n[nH]c2c1F)N[C@H](CO)c1ccccc1 CHEMBL3663003 IC50 0.3151 nM
COc1ccc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)cn1 CHEMBL3663092 IC50 0.3175 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cn2c(n1)C(=O)N(Cc1ccc(F)c(F)c1)[C@@H](C)C2 CHEMBL4440109 IC50 0.32 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnsn4)ncc23)ccn1 CHEMBL3658788 IC50 0.3229 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C4CC4)c3)c2cn1)c1ccccc1 CHEMBL3663055 IC50 0.326 nM
Cn1cncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4110831 IC50 0.326 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CCO)c4ccccc4)ncc23)ccn1 CHEMBL3658701 IC50 0.3329 nM
COC(=O)NC[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4115243 IC50 0.333 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(C#N)cc3)c2cn1)c1ccccc1 CHEMBL3663057 IC50 0.3352 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4111668 IC50 0.339 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc(NS(C)(=O)=O)c4)ncc23)ccn1 CHEMBL3658730 IC50 0.3398 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOCC3)c2c(C)n1)c1ccccc1 CHEMBL4108642 IC50 0.34 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cn2c(n1)C(=O)N(Cc1cccc(Cl)c1)CC2 CHEMBL4452853 IC50 0.34 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H](C)c4ccc(F)cc4)ncc23)ccn1 CHEMBL3703711 IC50 0.342 nM
Nc1ncc(C2CCC(=O)NC2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3965985 IC50 0.343 nM
COCC(=O)N[C@H]1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4108025 IC50 0.343 nM
C[C@@H](NC(=O)c1ccc(-c2cc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4107690 IC50 0.345 nM
COC(=O)N1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4112456 IC50 0.35 nM
Cc1cccc(CN2C(=O)c3cc(-c4ccnc(Nc5ccnn5C)n4)cn3CC2C)n1 CHEMBL4083098 IC50 0.35 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)CCN(Cc1ccc(F)c(F)c1)C2=O CHEMBL4587118 IC50 0.35 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CN)c4ccc(F)cc4)ncc23)ccn1 CHEMBL3662977 IC50 0.357 nM
O=C(Nc1cc2[nH]nc(-c3ccncc3)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL3663001 IC50 0.3577 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccccc4OCC(F)F)ncc23)ccn1 CHEMBL3662980 IC50 0.3584 nM
Nc1ncc(C2=CCCCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4113952 IC50 0.359 nM
O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 CHEMBL4112022 Ki 0.36 nM
Nc1ncc(C2CCC(NC(=O)CO)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3908768 IC50 0.363 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnc(O)nc3)c2cn1)c1ccccc1 CHEMBL3658658 IC50 0.3662 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccccc1 CHEMBL4114263 IC50 0.37 nM
Nc1ncc([C@H]2CC[C@@H](F)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4112116 IC50 0.371 nM
Nc1ncc([C@H]2CC[C@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CNCCF)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4110246 IC50 0.374 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)Nc4noc5cnccc45)ncc23)ccn1 CHEMBL3658724 IC50 0.3776 nM
Cc1cccc([C@@H](CO)NC(=O)c2ccc(-c3cc(-c4cnnn4C)cnc3N)cc2F)c1 CHEMBL4106528 IC50 0.378 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CN)c3ccccc3)c(F)c2)c1 CHEMBL4107745 IC50 0.38 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCCOc5ccccc54)ncc23)ccn1 CHEMBL3658642 IC50 0.3823 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cc[n+]([O-])cc3)c2cn1)c1ccccc1 CHEMBL3654744 IC50 0.383 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccsc4)ncc23)ccn1 CHEMBL3658837 IC50 0.3845 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](CO)c4ccccc4)ncc23)ccn1 CHEMBL3703715 IC50 0.3922 nM
CN1C[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)[C@H](c2ccccc2)C1 CHEMBL3654841 IC50 0.3938 nM
Nc1ncc(C2CCSCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3985297 IC50 0.397 nM
CCOc1ccc(C(=O)C2=C(O)C(=O)N(c3ncccn3)C2c2ccccc2)cc1 CHEMBL1421588 Potency 0.4 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccccc1Cl CHEMBL3409572 Ki 0.4 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409581 Ki 0.4 nM
O=C(N[C@H](CO)c1ccc(F)c(Cl)c1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3298414 Ki 0.4 nM
O=c1cc(-c2ccnc(NC3COC3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409603 Ki 0.4 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1cccc(Cl)c1 CHEMBL3409407 Ki 0.4 nM
CS(=O)(=O)c1cccc(Cn2ccc(N3CCc4[nH]nc(-c5ccncc5)c4C3)cc2=O)c1 CHEMBL3604852 IC50 0.4 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(Cl)c(Cl)c3)C(C)(C)O)nc(CO)c12 CHEMBL3917168 IC50 0.4 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(CO)n1)c1ccccc1 CHEMBL4108884 IC50 0.4 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)c(C)c3)C(C)(C)O)nc(CO)c12 CHEMBL3892731 IC50 0.4 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)c1ccccc1 CHEMBL3966700 IC50 0.4 nM
C[C@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)c1ccccc1 CHEMBL3956572 IC50 0.4 nM
C[C@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)c1ccc(F)cc1 CHEMBL3930671 IC50 0.4 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)nc(CO)c12 CHEMBL3899365 IC50 0.4 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)nc(CO)c12 CHEMBL3981912 IC50 0.4 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H](C)O)nc(CO)c12 CHEMBL4113494 IC50 0.4 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2c(CO)n1)c1ccccc1 CHEMBL4109763 IC50 0.4 nM
Cc1nc(NC(=O)N[C@@H](c2ccccc2)C(C)(C)O)cc2[nH]nc(OCCO)c12 CHEMBL3929367 IC50 0.4 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C3(O)CCC3)nc(CO)c12 CHEMBL4108379 IC50 0.4 nM
CC(C)(O)C(NC(=O)Nc1cc2[nH]nc(OC3CCOC3)c2cn1)c1ccc(F)cc1 CHEMBL4114350 IC50 0.4 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOC3)c2cn1)c1ccc(F)cc1 CHEMBL3900586 IC50 0.4 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccccc1 CHEMBL4109990 IC50 0.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccc(F)cc1 CHEMBL4107731 IC50 0.4 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2c(CO)n1)c1ccc(F)cc1 CHEMBL4114320 IC50 0.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4ncsc4C3)c2cn1)c1ccccc1 CHEMBL4111255 IC50 0.4 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4ncsc4C3)c2cn1)c1ccc(F)cc1 CHEMBL3892716 IC50 0.4 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3CC(F)(F)C3)c2cn1)c1ccc(F)cc1 CHEMBL3969660 IC50 0.4 nM
Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCCC3)ncc12 CHEMBL3895058 IC50 0.4 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)C(C)C)c2cn1)c1ccccc1 CHEMBL4109924 IC50 0.4 nM
COC[C@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccc(F)cc1 CHEMBL3916940 IC50 0.4 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCC3)c2cn1)c1ccccc1 CHEMBL4108250 IC50 0.4 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC(F)(F)CC3)c2cn1)c1ccccc1 CHEMBL3940265 IC50 0.4 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C3(O)CCC3)ncc12 CHEMBL4110027 IC50 0.4 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)ncc12 CHEMBL3966395 IC50 0.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4nn(C)cc4C3)c2cn1)c1ccc(F)cc1 CHEMBL4111032 IC50 0.4 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4nn(C)cc4C3)c2cn1)c1ccccc1 CHEMBL4112896 IC50 0.4 nM
O=C(Nc1cc2[nH]nc(N3CCOCC3)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4109695 IC50 0.4 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccc(F)cc1 CHEMBL3970161 IC50 0.4 nM
O=C(Nc1cc2[nH]nc(N3CCOCC3)c2cn1)N[C@H](COC(F)F)c1ccccc1 CHEMBL4109835 IC50 0.4 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)ncc12 CHEMBL3892204 IC50 0.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nn(C)cc4c3)c2cn1)c1ccc(F)cc1 CHEMBL3654714 IC50 0.4045 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)c(Cl)c4)ncc23)ccn1 CHEMBL3654707 IC50 0.411 nM
Cc1oncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)n1 CHEMBL4114086 IC50 0.416 nM
O=C(Nc1ncc2c(OCc3ccncc3)n[nH]c2c1F)N[C@H](CO)c1ccccc1 CHEMBL4106783 IC50 0.42 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4[C@H](c5ccccc5C)CN(C)[C@H]4C)ncc23)ccn1 CHEMBL3663010 IC50 0.4261 nM
C/C=C/c1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3654718 IC50 0.4285 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)Nc4noc5cccnc45)ncc23)ccn1 CHEMBL3662949 IC50 0.4285 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(F)c2)c(F)c1 CHEMBL4112681 IC50 0.429 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)[nH]c2CCN1[C@H](CO)c1ccccc1 CHEMBL4078489 IC50 0.43 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)c(Cl)c4)ncc23)ccn1 CHEMBL3654720 IC50 0.432 nM
[N-]=[N+]=NC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4113039 IC50 0.436 nM
COc1cc(F)ccc1CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3662975 IC50 0.4398 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)[C@@H](C(F)F)[C@@H]4c4ccccc4)ncc23)ccn1 CHEMBL3663022 IC50 0.4414 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CCN(CC(F)(F)F)C4)ncc23)ccn1 CHEMBL3658695 IC50 0.4475 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(C4COC4)c3)c2cn1)c1ccccc1 CHEMBL3663072 IC50 0.464 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4c(F)cccc4Cl)ncc23)ccn1 CHEMBL3658803 IC50 0.4685 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(C)c3)c2cn1)c1ccc(F)cc1 CHEMBL3654885 IC50 0.4687 nM
Cc1cccc(CN2CCc3[nH]c(-c4ccnc(NC5CCOCC5)n4)cc3C2=O)n1 CHEMBL4068705 IC50 0.47 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CF)c4ccccc4)ncc23)ccn1 CHEMBL3658718 IC50 0.4741 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCc4nc5ccccc5[nH]4)ncc23)ccn1 CHEMBL3658741 IC50 0.4776 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4[C@@H](c5ccccc5)CN(C)[C@@H]4C)ncc23)ccn1 CHEMBL3663023 IC50 0.479 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4cn(C)nc4c3)c2cn1)c1ccccc1 CHEMBL3663063 IC50 0.4809 nM
Nc1ncc([C@@H]2CCC(F)(F)[C@H](O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4110769 IC50 0.483 nM
Cc1ncc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)n1C CHEMBL4107037 IC50 0.487 nM
CC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccn1 CHEMBL3654845 IC50 0.4872 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCCOc5ccccc54)ncc23)ccn1 CHEMBL3658644 IC50 0.4939 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccc(F)c(F)c1 CHEMBL3409580 Ki 0.5 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1cc(F)cc(F)c1 CHEMBL3409583 Ki 0.5 nM
O=c1cc(N2CCc3[nH]nc(-c4ccncc4)c3C2)ccn1Cc1cccc(F)c1 CHEMBL3604849 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(CO)n1)c1ccccc1 CHEMBL3947147 IC50 0.5 nM
C[C@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(CO)n1)c1ccc(F)cc1 CHEMBL3950851 IC50 0.5 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(CO)n1)c1ccc(F)cc1 CHEMBL4113996 IC50 0.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(O)c3)nc(CO)c12 CHEMBL4107991 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)c1ccc(F)cc1 CHEMBL3895406 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccc(F)cc1 CHEMBL3971980 IC50 0.5 nM
O=C(Nc1cc2[nH]nc(OCCO)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4114143 IC50 0.5 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccccc1 CHEMBL4115146 IC50 0.5 nM
O=C(Nc1cc2[nH]nc(OC[C@H](O)C(F)(F)F)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4113148 IC50 0.5 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)ncc12 CHEMBL3954207 IC50 0.5 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOC3)c2c(CO)n1)c1ccccc1 CHEMBL4107533 IC50 0.5 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2c(CO)n1)c1ccc(F)cc1 CHEMBL4109158 IC50 0.5 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)nc(CO)c12 CHEMBL4110288 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCC(F)F)c2c(CO)n1)c1ccccc1 CHEMBL3924394 IC50 0.5 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C3(O)CCC3)nc(CO)c12 CHEMBL4113840 IC50 0.5 nM
CC1CC(Oc2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)CCO1 CHEMBL4108731 IC50 0.5 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)ncc12 CHEMBL3972200 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOC3)c2cn1)c1ccccc1 CHEMBL3971735 IC50 0.5 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2c(CO)n1)c1ccccc1 CHEMBL4109941 IC50 0.5 nM
Cc1nc(NC(=O)N[C@@H](c2ccc(F)cc2)[C@@H](C)O)cc2[nH]nc(N3CCOCC3)c12 CHEMBL4114432 IC50 0.5 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CC3CO4)c2cn1)c1ccccc1 CHEMBL4115126 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3CCC3)c2cn1)c1ccc(F)cc1 CHEMBL3936544 IC50 0.5 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC3COC3)c2cn1)c1ccccc1 CHEMBL4108159 IC50 0.5 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)C3CCC3)c2cn1)c1ccccc1 CHEMBL4112138 IC50 0.5 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)Cc3ccc(F)cc3)c2cn1)c1ccccc1 CHEMBL4108492 IC50 0.5 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4ncsc4C3)c2cn1)c1ccccc1 CHEMBL4109338 IC50 0.5 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)ncc12 CHEMBL3948938 IC50 0.5 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)OC)ncc12 CHEMBL3968853 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3)c2cn1)c1ccccc1 CHEMBL3931582 IC50 0.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CCC(C3)O4)c2cn1)c1ccccc1 CHEMBL3935586 IC50 0.5 nM
Cc1cc(-c2n[nH]c3c(F)c(NC(=O)N[C@H](C)c4ccc(Cl)cc4)ncc23)ccn1 CHEMBL3662989 IC50 0.5091 nM
Nc1ncc(-c2ccncc2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1 CHEMBL4108953 IC50 0.51 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(Cl)cc4)ncc23)ccn1 CHEMBL3654677 IC50 0.5126 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(C)c3)c2cn1)c1ccc(Cl)cc1 CHEMBL3654710 IC50 0.5141 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1)C1CCCCC1 CHEMBL3663013 IC50 0.516 nM
CCO[C@H]1CN(C)C[C@@H]1NC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3658687 IC50 0.5209 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4c4ccccc4C(F)(F)F)ncc23)ccn1 CHEMBL3654806 IC50 0.5272 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(CC(C)(C)O)c3)c2cn1)c1ccccc1 CHEMBL3663087 IC50 0.5352 nM
C[C@@H](NC(=O)c1ccc(-c2cc(C3CCNC(=O)C3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4112660 IC50 0.536 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CN(C)C[C@H]4c4ccccc4C)ncc23)ccn1 CHEMBL3654842 IC50 0.5369 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4c4ccccc4C)ncc23)ccn1 CHEMBL3654834 IC50 0.5374 nM
Nc1ncc([C@H]2CC[C@@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4109678 IC50 0.54 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4106865 IC50 0.544 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H](c4ccccc4)C4(O)CCCC4)ncc23)ccn1 CHEMBL3662986 IC50 0.5453 nM
CCOc1ncccc1CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3662981 IC50 0.5461 nM
C[C@@H](NC(=O)c1ccc(-c2cc(C3CCC(=O)NC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4114958 IC50 0.549 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(OC(F)F)cc2)cn1 CHEMBL3920813 IC50 0.55 nM
CN(C(=O)/C=C/c1ccoc1)[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5 CHEMBL267495 EC50 0.55 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(Cl)cc4)ncc23)ccn1 CHEMBL3654670 IC50 0.5556 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(C)=O)c2cn1)c1ccc(F)cc1 CHEMBL4115379 IC50 0.56 nM
CC(=O)NC1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL3890881 IC50 0.561 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CCCCC4)ncc23)ccn1 CHEMBL3663032 IC50 0.5614 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nn(C)cc4c3)c2cn1)c1ccc(Cl)cc1 CHEMBL3654716 IC50 0.5616 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4c(c3)nnn4C)c2cn1)c1ccc(F)cc1 CHEMBL3658669 IC50 0.5622 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(c4ccccc4)C4CCCO4)ncc23)ccn1 CHEMBL3654863 IC50 0.566 nM
C[C@@H](NC(=O)Nc1ncc2c(OCc3ccncc3)n[nH]c2c1F)c1ccccc1 CHEMBL4107370 IC50 0.57 nM
Cc1cnccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)c1 CHEMBL4112111 IC50 0.574 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nncn4c3)c2cn1)c1ccc(F)cc1 CHEMBL3654872 IC50 0.5805 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4ccc(S(C)(=O)=O)cc4)ncc23)ccn1 CHEMBL3658740 IC50 0.5815 nM
C[C@@H](NC(=O)c1ccc(-c2nc(C3=CCCCC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4110523 IC50 0.585 nM
Cn1cc2cc(-c3n[nH]c4cc(NC(=O)NCc5ccc(F)c(Cl)c5)ncc34)ccc2n1 CHEMBL3654715 IC50 0.5861 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccsn4)ncc23)ccn1 CHEMBL3658838 IC50 0.5869 nM
COC1CCCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)C1 CHEMBL4114008 IC50 0.593 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnsc4)ncc23)ccn1 CHEMBL3658786 IC50 0.594 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(F)c4)c(F)c3)c2)cnn1C CHEMBL4109292 IC50 0.595 nM
N#Cc1cccc(C(CO)n2ccc(-c3ccnc(NC4CCOCC4)n3)cc2=O)c1 CHEMBL3409579 Ki 0.6 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409588 Ki 0.6 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)cnn1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409595 Ki 0.6 nM
N#CC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(F)c(Cl)c1 CHEMBL4106654 IC50 0.6 nM
Cn1cc([C@@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2ccc(C#N)c(Cl)c2)cn1 CHEMBL3976284 IC50 0.6 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cnn(C)c2)cc1Cl CHEMBL3952319 IC50 0.6 nM
O=C(Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4114532 IC50 0.6 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)c1ccccc1 CHEMBL4107375 IC50 0.6 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)[C@H](C)O)ncc12 CHEMBL3947239 IC50 0.6 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)[C@@H](C)O)ncc12 CHEMBL4114279 IC50 0.6 nM
C[C@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccccc1 CHEMBL3953044 IC50 0.6 nM
O=C(Nc1cc2[nH]nc(OC3CCOCC3)c2cn1)NC1CCCOc2ccccc21 CHEMBL3948992 IC50 0.6 nM
CCOCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)nc(CO)c12 CHEMBL4107216 IC50 0.6 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2cn1)N[C@H]1c2ccccc2OCC[C@H]1O CHEMBL4108518 IC50 0.6 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)ncc12 CHEMBL3922668 IC50 0.6 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(CO)c12 CHEMBL4114637 IC50 0.6 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOC(C(F)(F)F)C3)c2cn1)c1ccccc1 CHEMBL3907091 IC50 0.6 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@H]3CCCO3)ncc12 CHEMBL4113074 IC50 0.6 nM
CC(C)C(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4114063 IC50 0.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)Cc3ccccc3)c2cn1)c1ccccc1 CHEMBL4109852 IC50 0.6 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](COC(F)F)c3ccccc3)ncc12 CHEMBL4107484 IC50 0.6 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@H]3CCCO3)ncc12 CHEMBL4107325 IC50 0.6 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](COC(F)F)c3ccccc3)ncc12 CHEMBL4111579 IC50 0.6 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC(F)(F)C3)c2cn1)c1ccccc1 CHEMBL3903262 IC50 0.6 nM
CC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)ncc12 CHEMBL3892937 IC50 0.6 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(C)C(F)(F)F)c2cn1)c1ccccc1 CHEMBL4111461 IC50 0.6 nM
CCNc1n[nH]c2cc(NC(=O)NC(c3ccc(F)cc3)C(C)(C)OC)ncc12 CHEMBL3890482 IC50 0.6 nM
COC[C@H]1Cn2cc(-c3nc(Nc4ccnn4C)ncc3C)cc2C(=O)N1Cc1cccc(C)n1 CHEMBL4551714 IC50 0.6 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(C)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658664 IC50 0.6014 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CO)c4cc(F)cc(F)c4)ncc23)ccn1 CHEMBL3658729 IC50 0.6026 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cn[nH]c3)c2cn1)c1ccc(F)c(Cl)c1 CHEMBL3654725 IC50 0.6032 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccccc4OC(F)(F)F)ncc23)ccn1 CHEMBL3662978 IC50 0.6051 nM
COc1ncccc1CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3662951 IC50 0.6076 nM
CCOCCNC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3663065 IC50 0.6099 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(C)C)c2cn1)c1ccccc1 CHEMBL4107121 IC50 0.61 nM
CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cc(F)cc(S(C)(=O)=O)c4)c(F)c3)c2)cn1 CHEMBL4115487 IC50 0.617 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1)c1ccc(F)cc1 CHEMBL3663081 IC50 0.6208 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCO[C@H](C)C3)c2cn1)c1ccccc1 CHEMBL4111860 IC50 0.63 nM
CC1(C)OB(C2=CCOCC2)OC1(C)C CHEMBL3942505 IC50 0.631 nM
Cc1oncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)c1 CHEMBL4109608 IC50 0.634 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)c(C#N)n1 CHEMBL4109989 IC50 0.653 nM
Nc1ncc([C@H]2CC[C@@H](O)[C@@H](F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3921988 IC50 0.653 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4c(F)cccc4F)ncc23)ccn1 CHEMBL3654703 IC50 0.6547 nM
CC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4115383 IC50 0.66 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4c4ccccc4F)ncc23)ccn1 CHEMBL3654811 IC50 0.6619 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccn4ncnc4c3)c2cn1)c1ccccc1 CHEMBL3658662 IC50 0.6653 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL4115633 IC50 0.67 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H](COC)c3ccc(F)cc3)ncc12 CHEMBL3907318 IC50 0.67 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4nn(C)cc4c3)c2cn1)c1cccc(Cl)c1 CHEMBL3654713 IC50 0.6722 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC(C)c4ccccc4)ncc23)ccn1 CHEMBL3663037 IC50 0.6794 nM
Cc1cc(-c2cc(C3CCOCC3)cnc2N)ccc1C(=O)N[C@H](CO)c1ccccc1 CHEMBL4114469 IC50 0.684 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ncccc4F)ncc23)ccn1 CHEMBL3654858 IC50 0.6987 nM
CCC1=NN(C(=O)COc2ccccc2)C(O)(c2ccncc2)C1 CHEMBL1364665 Potency 0.7 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1ccc(Cl)c(F)c1 CHEMBL3409569 Ki 0.7 nM
Cc1cccc(Cn2ccc(N3CCc4[nH]nc(-c5ccncc5)c4C3)cc2=O)c1 CHEMBL3604853 IC50 0.7 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@@H]1CNC[C@H]1c1ccc(C(F)(F)F)cc1)CC2 CHEMBL3910034 IC50 0.7 nM
CCC(O)c1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4110418 IC50 0.7 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccccc1 CHEMBL3937971 IC50 0.7 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OC[C@H](O)C(F)(F)F)c2cn1)c1ccccc1 CHEMBL3924896 IC50 0.7 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2c(CO)n1)N[C@@H](c1ccccc1)C1(O)CCC1 CHEMBL4108924 IC50 0.7 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)nc(CO)c12 CHEMBL4107769 IC50 0.7 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCC(F)F)c2c(CO)n1)c1ccc(F)cc1 CHEMBL3936722 IC50 0.7 nM
O=C(Nc1cc2[nH]nc(OC3CCOCC3)c2cn1)N[C@H](COC(F)F)c1ccccc1 CHEMBL4109236 IC50 0.7 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](CO)c3ccccc3)ncc12 CHEMBL4110945 IC50 0.7 nM
Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@H]3CCCO3)ncc12 CHEMBL4110854 IC50 0.7 nM
COCC(NC(=O)Nc1cc2[nH]nc(NCC3CCC3)c2cn1)c1ccccc1 CHEMBL3940121 IC50 0.7 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCCC3)ncc12 CHEMBL3894541 IC50 0.7 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(Cl)c3)ncc12 CHEMBL4115083 IC50 0.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCc3cccnc3)c2cn1)c1ccccc1 CHEMBL4108268 IC50 0.7 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(C)C)c2cn1)c1ccc(F)cc1 CHEMBL4112799 IC50 0.7 nM
Cc1nc(NC(=O)N[C@@H](C)c2ccccc2)cc2[nH]nc(N)c12 CHEMBL3943792 IC50 0.7 nM
COCCNc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL4113938 IC50 0.7 nM
CC(Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)ncc12)C(F)(F)F CHEMBL3953819 IC50 0.7 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccc(F)cc1 CHEMBL3978815 IC50 0.7 nM
COc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(N)c12 CHEMBL4106612 IC50 0.7 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)ccc2CN1C(CO)c1cccc(Cl)c1 CHEMBL4434915 IC50 0.7 nM
CC(C)Nc1ncc(Cl)c(-c2c[nH]c(C(=O)N[C@H](CO)c3cccc(Cl)c3)c2)n1 CHEMBL4571588 IC50 0.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(C)c3)c2cn1)c1ccc(F)c(Cl)c1 CHEMBL3654723 IC50 0.7088 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc(Cl)c4)ncc23)ccn1 CHEMBL3654678 IC50 0.7129 nM
CCNC(=O)[C@H]1CC1c1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL3654798 IC50 0.7146 nM
COc1ncc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)cn1 CHEMBL3658681 IC50 0.7166 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)[nH]c2CCN1[C@H](CO)c1ccc(F)c(Cl)c1 CHEMBL4096522 IC50 0.72 nM
Cc1nc2ccc(-c3n[nH]c4cc(NC(=O)N[C@H](C)c5ccccc5)ncc34)cc2o1 CHEMBL3663094 IC50 0.7204 nM
C[C@@H](NC(=O)Nc1ncc2c(-c3ccnc(F)c3)n[nH]c2c1F)c1ccccc1 CHEMBL3662994 IC50 0.7282 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)n2)cnn1C CHEMBL4109127 IC50 0.73 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4c4ccc(F)cc4)ncc23)ccn1 CHEMBL3654838 IC50 0.7313 nM
Cc1cc(-c2n[nH]c3cc(NC4NC(c5ccccc5)CN(C)O4)ncc23)ccn1 CHEMBL3658702 IC50 0.7388 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cscn4)ncc23)ccn1 CHEMBL3658795 IC50 0.7445 nM
COc1ncc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cc4)ncc23)cn1 CHEMBL3654878 IC50 0.7464 nM
Cc1nc2ccc(-c3n[nH]c4cc(NC(=O)N[C@H](C)c5ccccc5)ncc34)cc2s1 CHEMBL3654738 IC50 0.7479 nM
Cn1nccc1Nc1cc2nc(C(=O)N[C@H](CO)c3ccc(Cl)c(F)c3)ccc2cn1 CHEMBL4108790 IC50 0.748 nM
COc1ncc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCCOc5ccccc54)ncc23)cn1 CHEMBL3658680 IC50 0.7508 nM
CC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(Cl)cc1 CHEMBL3658778 IC50 0.7549 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)NCc2cccc(Cl)c2)c(F)c1 CHEMBL3905523 IC50 0.758 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncc(F)cc4Cl)ncc23)ccn1 CHEMBL3662973 IC50 0.7607 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCc5[nH]nc(C)c5C4)ncc23)ccn1 CHEMBL3662963 IC50 0.7618 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1)c1ccccn1 CHEMBL3662956 IC50 0.778 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccn1 CHEMBL3658780 IC50 0.7803 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(N4CCOCC4)nc3)c2cn1)c1ccc(F)cc1 CHEMBL3654881 IC50 0.7832 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC[C@@H](C)c4ccccc4)ncc23)ccn1 CHEMBL3663071 IC50 0.7895 nM
C[C@@H](NC(=O)c1ccc(-c2nc(C3CC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4110106 IC50 0.794 nM
COCCNC(=O)Nc1cc2[nH]nc(-c3ccc4nn(C)cc4c3)c2cn1 CHEMBL3663074 IC50 0.7996 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1ccccc1 CHEMBL3409406 Ki 0.8 nM
Cn1cc(C(c2ccc(Cl)c(Cl)c2)n2ccc(-c3nc(NC4CCOCC4)ncc3F)cc2=O)cn1 CHEMBL3675723 IC50 0.8 nM
Cn1cc(C(NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3890004 IC50 0.8 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(CO)n1)c1ccc(F)cc1 CHEMBL3926641 IC50 0.8 nM
C[C@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(CO)n1)c1ccccc1 CHEMBL3942130 IC50 0.8 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCCC3)ncc12 CHEMBL3904545 IC50 0.8 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)c(F)c3)C(C)(C)O)nc(CO)c12 CHEMBL3921649 IC50 0.8 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)[C@@H](C)O)ncc12 CHEMBL4107858 IC50 0.8 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)nc(C(F)F)c12 CHEMBL3904955 IC50 0.8 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)(F)F)c2cn1)c1ccccc1 CHEMBL3978911 IC50 0.8 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc([C@H](C)O)c12 CHEMBL4112910 IC50 0.8 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2c(CO)n1)N[C@@H](c1ccccc1)C1(O)CC1 CHEMBL3960094 IC50 0.8 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOCC3)c2cn1)c1ccccc1 CHEMBL3985412 IC50 0.8 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](CO)c3ccccc3)ncc12 CHEMBL4108026 IC50 0.8 nM
COCCOc1n[nH]c2cc(NC(=O)NC(c3ccc(Cl)cc3)C(C)(C)O)ncc12 CHEMBL3895154 IC50 0.8 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)O)ncc12 CHEMBL4108072 IC50 0.8 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@@H]3CCOC3)c2cn1)c1ccccc1 CHEMBL4114934 IC50 0.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@H]3COC[C@H]3F)c2cn1)c1ccccc1 CHEMBL4108214 IC50 0.8 nM
CC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](C)c3ccccc3)ncc12 CHEMBL3977991 IC50 0.8 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H]3CCCO3)ncc12 CHEMBL3927224 IC50 0.8 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCOCC3)c2cn1)c1ccccc1 CHEMBL4112471 IC50 0.8 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](CSC)c3ccccc3)ncc12 CHEMBL4114345 IC50 0.8 nM
C[C@@H]1CN(c2n[nH]c3cc(NC(=O)N[C@@H](c4ccccc4)C(C)(C)O)ncc23)C[C@H](C)O1 CHEMBL3930108 IC50 0.8 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CC3CO4)c2cn1)c1ccc(F)cc1 CHEMBL3984501 IC50 0.8 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)ccc2CN1[C@H](CO)c1cccc(Cl)c1 CHEMBL4449385 IC50 0.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1)c1ccccc1 CHEMBL3654681 IC50 0.8 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCc5[nH]ncc5C4)ncc23)ccn1 CHEMBL3662962 IC50 0.805 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(N4CCNCC4)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658674 IC50 0.8097 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@@H](CN)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL3917361 IC50 0.811 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H]4C[C@@H]4c4ccccc4)c(F)c3)c2)cn1 CHEMBL4115410 IC50 0.813 nM
C[C@@H](O)[C@@H](NC(=O)c1ccc(-c2nc(-c3cnn(C)c3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4111016 IC50 0.815 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccccc4F)ncc23)ccn1 CHEMBL3658805 IC50 0.8152 nM
C[C@@H](NC(=O)c1ccc(-c2nc(C3CCOCC3)cnc2N)cc1F)c1ccccc1 CHEMBL4113120 IC50 0.818 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCCC3)c2cn1)c1ccccc1 CHEMBL4108232 IC50 0.82 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnn(C)c3)c2cn1)C1CCCCC1 CHEMBL3663042 IC50 0.8229 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncccc4Cl)ncc23)ccn1 CHEMBL3658811 IC50 0.8272 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cn2c(n1)C(=O)N(Cc1ccc(F)c(F)c1)CC2 CHEMBL4458562 IC50 0.83 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)nn1 CHEMBL3911903 IC50 0.835 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCc4cn[nH]c4)ncc23)ccn1 CHEMBL3658758 IC50 0.85 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccccc4)ncc23)ccn1 CHEMBL2408788 IC50 0.8512 nM
C[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4110629 IC50 0.853 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cn4)ncc23)ccn1 CHEMBL3662959 IC50 0.8579 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(C#N)cc4)ncc23)ccn1 CHEMBL3654860 IC50 0.8612 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCc5cccnc5C4)ncc23)ccn1 CHEMBL3662961 IC50 0.8648 nM
CO[C@@H](C)CNC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3663083 IC50 0.8733 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)cnn1 CHEMBL3654742 IC50 0.8779 nM
Nc1ncc(C2CCOCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4108211 IC50 0.879 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnc(OC)nc3)c2cn1)c1ccccc1 CHEMBL3658682 IC50 0.88 nM
CN1CC(c2ccccc2)NC(Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)O1 CHEMBL3654850 IC50 0.8856 nM
Cn1nccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(S(C)(=O)=O)c3)c(F)c2)c1 CHEMBL4108598 IC50 0.899 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)ncc12 CHEMBL3943581 IC50 0.9 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)c1ccc(F)cc1 CHEMBL4108615 IC50 0.9 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOCC3)c2cn1)c1ccccc1 CHEMBL4111633 IC50 0.9 nM
CC1CC(Oc2n[nH]c3cc(NC(=O)N[C@@H](c4ccc(F)cc4)C(C)(C)O)ncc23)CC(C)O1 CHEMBL3913205 IC50 0.9 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC3)c2c(CO)n1)c1ccc(F)cc1 CHEMBL3971505 IC50 0.9 nM
Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H]3CCCO3)ncc12 CHEMBL3892129 IC50 0.9 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCCC3)ncc12 CHEMBL3973779 IC50 0.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CC3)c2cn1)c1ccccc1 CHEMBL4110504 IC50 0.9 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NCC(F)(F)F)c2cn1)c1ccccc1 CHEMBL4106908 IC50 0.9 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC(F)(F)CC3)c2cn1)c1ccc(F)cc1 CHEMBL4111491 IC50 0.9 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CCC(C3)O4)c2cn1)c1ccccc1 CHEMBL4108054 IC50 0.9 nM
Cc1cnccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2)c1 CHEMBL4107892 IC50 0.9 nM
Cc1cccc(CN2C(=O)c3cc(-c4nc(Nc5ccnn5C)ncc4C)cn3C[C@@H]2C)n1 CHEMBL4075638 IC50 0.9 nM
Cc1n[nH]cc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL4565958 IC50 0.9 nM
COc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)ccn1 CHEMBL3663099 IC50 0.9 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccn4)ncc23)ccn1 CHEMBL3654805 IC50 0.9142 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4C[C@H]4c4ccccc4)ncc23)ccn1 CHEMBL3663036 IC50 0.9168 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(C)n1)c1ccccc1 CHEMBL4109615 IC50 0.92 nM
Nc1ncc([C@@H]2CC[C@H](O)[C@H](F)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL3937459 IC50 0.924 nM
COc1cccc(F)c1CN1CCC[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccc5nn(C)cc5c4)c3cn2)C1 CHEMBL3663100 IC50 0.9287 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4csc(C)n4)ncc23)ccn1 CHEMBL3654694 IC50 0.9342 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(c4ccc(F)cc4)C4CCCO4)ncc23)ccn1 CHEMBL3654864 IC50 0.9352 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC(c4ccccc4)C4(O)CCOCC4)ncc23)ccn1 CHEMBL3658749 IC50 0.939 nM
Cc1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)ccn1 CHEMBL4571067 IC50 0.94 nM
COc1ccc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)cc1 CHEMBL3663114 IC50 0.9404 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccc(F)c(Cl)c4)c(F)c3)c2)cn1 CHEMBL4110347 IC50 0.944 nM
CO[C@@H](C)CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3663048 IC50 0.9449 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)cc4)ncc23)ccn1 CHEMBL3658643 IC50 0.9454 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CNc5ccccc5C4)ncc23)ccn1 CHEMBL3662957 IC50 0.9578 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4c(F)cc(F)cc4F)ncc23)ccn1 CHEMBL3639618 IC50 0.9623 nM
CNC(=O)[C@H]1CC1c1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL3654799 IC50 0.9695 nM
CN1CC[C@@H](CNC(=O)Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)C1 CHEMBL3658689 IC50 0.9863 nM
O=C(NCc1ccno1)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3654849 IC50 0.9946 nM
CCn1ncc2cc3nc(c21)C[C@H](O)COC[C@H](c1cccc(Cl)c1)NC(=O)N3 CHEMBL3902533 IC50 0.9958 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4ccc(F)c(F)c4)ncc23)ccn1 CHEMBL3658697 IC50 0.9977 nM
Cn1cnnc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(Cl)c3)c(F)c2)c1 CHEMBL4113526 IC50 0.998 nM
Nc1ccc(O)c([N+](=O)[O-])c1 CHEMBL1516868 Potency 1.0 nM
C=CC(=O)NCNC(=O)C=C CHEMBL1401480 Potency 1.0 nM
[O-]Cl CHEMBL1334078 Potency 1.0 nM
O=C1C(O)=C(Cc2ccccc2)C(=O)c2ccccc21 CHEMBL1317916 Potency 1.0 nM
Cc1cc(C)c(N)cc1C CHEMBL541229 Potency 1.0 nM
CC1(C)OC(C(O)(c2ccccc2)c2ccccc2)C(C(O)(c2ccccc2)c2ccccc2)O1 CHEMBL1397851 Potency 1.0 nM
Cc1c(C(=O)c2cccc3ccccc23)c2cccc3c2n1[C@H](CN1CCOCC1)CO3 CHEMBL1222317 Potency 1.0 nM
CC[C@H]1C(=O)OC[C@H]1Cc1cncn1C CHEMBL611494 Potency 1.0 nM
CN1Cc2c(N)cccc2C(c2ccccc2)C1 CHEMBL273575 Potency 1.0 nM
CCCN(CCC)C(=O)SCC CHEMBL1371350 Potency 1.0 nM
O=C(N[C@H](CO)c1ccc(Cl)c(Cl)c1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3298982 IC50 1.0 nM
C[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1 CHEMBL3298984 IC50 1.0 nM
CC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(C#N)c(Cl)c1 CHEMBL3298985 IC50 1.0 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@H](C)c1ccc(Cl)c(Cl)c1)CC2 CHEMBL3298308 IC50 1.0 nM
Cc1cc(Nc2ncc3c(n2)CN(C(=O)N[C@H](C)c2ccc(Cl)c(Cl)c2)CC3)ccn1 CHEMBL3298418 IC50 1.0 nM
C[C@@H](NC(=O)N1CCc2cnc(Nc3cnn(C)c3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL3357950 IC50 1.0 nM
C[C@@H](NC(=O)N1CCc2cnc(Nc3ccnn3C)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL3357951 IC50 1.0 nM
COc1cc(CO)ccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1 CHEMBL3671094 IC50 1.0 nM
COc1c(CO)cccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1 CHEMBL3671096 IC50 1.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3cn[nH]c3)nc2n1 CHEMBL3671097 IC50 1.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3ccc(O)cc3)nc2n1 CHEMBL3671098 IC50 1.0 nM
COc1cc(-c2cnc3ccc(NC(=O)NCCCCc4ccccc4)nc3n2)ccc1C(=O)O CHEMBL3671121 IC50 1.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc2n1 CHEMBL3671122 IC50 1.0 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2cnn(C)c2)cc1Cl CHEMBL3944233 IC50 1.0 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2cn1)N[C@@H](c1ccccc1)C1(O)CCCC1 CHEMBL3941892 IC50 1.0 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)O)nc(-c3cnco3)c12 CHEMBL4112480 IC50 1.0 nM
O=C(Nc1cc2[nH]nc(OCCOC(F)(F)F)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4110223 IC50 1.0 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(CO)c12 CHEMBL4106840 IC50 1.0 nM
CC(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCC(F)F)c2c(CO)n1)c1ccc(F)cc1 CHEMBL4110491 IC50 1.0 nM
CC1CC(Oc2n[nH]c3cc(NC(=O)N[C@@H](c4ccccc4)C(C)(C)O)ncc23)CC(C)O1 CHEMBL3975320 IC50 1.0 nM
CC(C)(O)[C@H](NC(=O)Nc1cc2[nH]nc(OC3CCOC3)c2cn1)c1ccc(F)cc1 CHEMBL4111814 IC50 1.0 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4106867 IC50 1.0 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCCC3)c2cn1)c1ccccc1 CHEMBL4110622 IC50 1.0 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(C)=O)c2cn1)c1ccccc1 CHEMBL4110792 IC50 1.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCc3ccncc3)c2cn1)c1ccccc1 CHEMBL4109847 IC50 1.0 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H]3CN(C)C[C@H]3c3ccccc3)ncc12 CHEMBL3913064 IC50 1.0 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3cccc(Cl)c3)ncc12 CHEMBL4113650 IC50 1.0 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H]3CN(C)C[C@H]3c3ccccc3)ncc12 CHEMBL3941741 IC50 1.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)C3CC3)c2cn1)c1ccccc1 CHEMBL4112973 IC50 1.0 nM
COC[C@H](NC(=O)Nc1cc2[nH]nc(N3CCCC3)c2cn1)c1ccc(F)cc1 CHEMBL3916468 IC50 1.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCOCC3)c2cn1)c1ccccc1 CHEMBL4113913 IC50 1.0 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CC3)c2cn1)c1ccccc1 CHEMBL4113059 IC50 1.0 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC(OC)CC3)c2cn1)c1ccccc1 CHEMBL4107608 IC50 1.0 nM
COC1CCN(c2n[nH]c3cc(NC(=O)N[C@H](COC(F)F)c4ccccc4)ncc23)CC1 CHEMBL4111311 IC50 1.0 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cncc(F)c4)ncc23)ccn1 CHEMBL3654702 IC50 1.001 nM
O=C(NCc1ccc(F)c(Cl)c1)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1 CHEMBL3654709 IC50 1.002 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CO)c4cccnc4)ncc23)ccn1 CHEMBL3658703 IC50 1.029 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4cccnc4)ncc23)ccn1 CHEMBL3654700 IC50 1.04 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL4107817 IC50 1.04 nM
CN1C[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CCC1=O CHEMBL3977417 IC50 1.05 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(N4CCOCC4)nc3)c2cn1)c1ccc(F)cc1 CHEMBL3658665 IC50 1.051 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(C#N)cc3)c2cn1)c1ccccc1 CHEMBL3654717 IC50 1.056 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4cc(Cl)ccn4)ncc23)ccn1 CHEMBL3654856 IC50 1.056 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1 CHEMBL3941372 IC50 1.06 nM
COc1cccc(F)c1CN1CCC[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccnc(F)c4)c3cn2)C1 CHEMBL3663091 IC50 1.062 nM
CCN(CC)CCC(NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1 CHEMBL3658770 IC50 1.065 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCC4COc5ccccc5O4)ncc23)ccn1 CHEMBL3658737 IC50 1.066 nM
CCOCCNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3663066 IC50 1.067 nM
COC(=O)C1CC1c1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3663089 IC50 1.069 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccccc1 CHEMBL4114190 IC50 1.07 nM
Cn1nccc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(F)c3)c(F)c2)c1 CHEMBL4106603 IC50 1.07 nM
Cc1cc(-c2cc(-c3cnn(C)c3)cnc2N)ccc1C(=O)N[C@H](CO)c1ccccc1 CHEMBL4108634 IC50 1.08 nM
CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(S(C)(=O)=O)c4)c(F)c3)c2)cn1 CHEMBL4110436 IC50 1.08 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccno4)ncc23)ccn1 CHEMBL3658798 IC50 1.082 nM
CN1CC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CCC1=O CHEMBL3935684 IC50 1.09 nM
COCCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)cn1 CHEMBL4114965 IC50 1.09 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1CCc1ccc(Cl)c(F)c1 CHEMBL3409570 Ki 1.1 nM
O=C(N[C@@H](c1ccc(Cl)c(Cl)c1)c1cnco1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3955508 IC50 1.1 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)NC(c1ccc(C(F)(F)F)c(F)c1)[C@H]1CCCN1)CC2 CHEMBL4106599 IC50 1.1 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CO)c1ccc(Cl)c(Cl)c1)CC2 CHEMBL4112440 IC50 1.1 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@H](CCO)c1ccc(Cl)c(Cl)c1)CC2 CHEMBL3928991 IC50 1.1 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3900450 IC50 1.1 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(C#N)c(Cl)c2)cn1 CHEMBL3890923 IC50 1.1 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cncn2C)cc1F CHEMBL3932745 IC50 1.1 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOC3)c2cn1)c1ccccc1 CHEMBL4110284 IC50 1.1 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(C)c3)nc(CO)c12 CHEMBL4108276 IC50 1.1 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OC[C@@H](O)C(F)(F)F)c2cn1)c1ccccc1 CHEMBL4109593 IC50 1.1 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](CSC)c3ccccc3)ncc12 CHEMBL4112820 IC50 1.1 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H]3CNC[C@@H]3c3ccccc3)ncc12 CHEMBL4109834 IC50 1.1 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(Cl)cc3)C(C)(C)O)ncc12 CHEMBL3911224 IC50 1.1 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC3)c2cn1)c1ccc(F)cc1 CHEMBL3933758 IC50 1.1 nM
C[C@@H]1CN(c2n[nH]c3cc(NC(=O)N[C@@H](c4ccccc4)C(C)(C)O)ncc23)C[C@H](C(F)(F)F)O1 CHEMBL4114996 IC50 1.1 nM
COCC(NC(=O)Nc1cc2[nH]nc(NC3CCOC3)c2cn1)c1ccccc1 CHEMBL3934597 IC50 1.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)CC(F)(F)F)c2cn1)c1ccccc1 CHEMBL4108771 IC50 1.1 nM
Cc1nnsc1C(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4110775 IC50 1.1 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)OC)c2cn1)c1ccc(F)cc1 CHEMBL4106736 IC50 1.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc3c2c(n1)COC(=O)N3)c1ccccc1 CHEMBL4110330 IC50 1.1 nM
COCCNc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccc(F)cc3)ncc12 CHEMBL4112265 IC50 1.1 nM
CC(C)OC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)ncc12 CHEMBL3905037 IC50 1.1 nM
CCNc1n[nH]c2cc(NC(=O)NC(c3ccc(F)cc3)C(C)(C)O)ncc12 CHEMBL3920826 IC50 1.1 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)[nH]c2CCN1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL4100076 IC50 1.1 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)C(=O)N([C@H](CO)c3cccc(Cl)c3)C4)n2)cn1 CHEMBL4435679 IC50 1.1 nM
COc1cc(F)cc([C@@H](CO)NC(=O)CN2C(=O)c3cc(-c4nc(NC5CCOCC5)ncc4Cl)ccc3[C@H]2C)c1 CHEMBL4871302 IC50 1.1 nM
COc1cc(F)cc([C@@H](CO)NC(=O)CN2Cc3ccc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)c1 CHEMBL4869086 IC50 1.1 nM
CC(=O)N[C@H]1CC[C@@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4109963 IC50 1.11 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4c(C)cccc4Cl)ncc23)ccn1 CHEMBL3658807 IC50 1.116 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccns4)ncc23)ccn1 CHEMBL3658792 IC50 1.117 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4113114 IC50 1.13 nM
CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)n2)cn1 CHEMBL3933434 IC50 1.13 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4(Nc5ccccc5)CCOCC4)ncc23)ccn1 CHEMBL3658762 IC50 1.131 nM
CO[C@H]1CN(C)C[C@@H]1NC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3658685 IC50 1.133 nM
Cc1cc(-c2n[nH]c3c(F)c(NC(=O)NCc4ccccc4)ncc23)ccn1 CHEMBL3662991 IC50 1.138 nM
C[C@@H](NC(=O)c1ccc(-c2nc(C3CCN(S(C)(=O)=O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4108020 IC50 1.14 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnc(C)s4)ncc23)ccn1 CHEMBL3658797 IC50 1.142 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@@H](C)CO)cc3n2)c2cnn(C)c2)cc1F CHEMBL3953138 IC50 1.15 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc4c(c3)OCCO4)c2cn1)c1ccccc1 CHEMBL3654739 IC50 1.156 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnc(OC)nc3)c2cn1)c1ccc(F)cc1 CHEMBL3658667 IC50 1.159 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)cn1 CHEMBL4112380 IC50 1.16 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(N4CCOCC4)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658666 IC50 1.172 nM
CN1CC[C@H](CNC(=O)Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)C1 CHEMBL3658690 IC50 1.174 nM
Nc1ncc(-c2ccnnc2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4106512 IC50 1.18 nM
CS(=O)(=O)c1cc(Cl)cc(CNC(=O)c2ccc(-c3nc(C4CCOCC4)cnc3N)cc2F)c1 CHEMBL3924859 IC50 1.19 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnc(F)cc4Cl)ncc23)ccn1 CHEMBL3662967 IC50 1.199 nM
O=c1cc(-c2ccnc(NC3CC(F)(F)C3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409604 Ki 1.2 nM
CC(CO)Nc1ncc2ccc(C(=O)N[C@@H](c3ccc(Cl)c(F)c3)c3cnn(C)c3)cc2n1 CHEMBL4112491 IC50 1.2 nM
O=C(N[C@@H](c1ccc(F)c(Cl)c1)[C@@]1(F)CCNC1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3946491 IC50 1.2 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@H]4CC[C@H](O)CC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3899752 IC50 1.2 nM
Cn1cc([C@@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cccc(F)c2)cn1 CHEMBL3970902 IC50 1.2 nM
COCCOC(=N)c1cnc(NC(=O)N[C@@H](c2ccccc2)C2(O)CCC2)cc1N CHEMBL3909516 IC50 1.2 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H]3CN(C)C[C@@H]3c3ccccc3)ncc12 CHEMBL4114542 IC50 1.2 nM
CCOc1n[nH]c2cc(NC(=O)NC(CN3CCOCC3)c3ccccc3)ncc12 CHEMBL3910096 IC50 1.2 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CC3)ncc12 CHEMBL3926744 IC50 1.2 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(Cl)c3)nc(CO)c12 CHEMBL4107801 IC50 1.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccc(F)cc1 CHEMBL4114438 IC50 1.2 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc([C@@H](C)O)c12 CHEMBL4108190 IC50 1.2 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCOCC3C)c2cn1)c1ccccc1 CHEMBL4110702 IC50 1.2 nM
CC(C)N1CCc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3[nH]nc1c23 CHEMBL4107272 IC50 1.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)C3CCCC3)c2cn1)c1ccccc1 CHEMBL4112304 IC50 1.2 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)OC)c2cn1)c1ccccc1 CHEMBL4111208 IC50 1.2 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)NCc3c(F)cccc3OC)ncc12 CHEMBL3966758 IC50 1.2 nM
Nc1n[nH]c2cc(NC(=O)C[C@H](COC(F)F)c3ccccc3)ncc12 CHEMBL4110235 IC50 1.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCSC3)c2cn1)c1ccccc1 CHEMBL4111590 IC50 1.2 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC(O)CC3)c2cn1)c1ccccc1 CHEMBL4112937 IC50 1.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2c(Cl)n1)c1ccccc1 CHEMBL4109948 IC50 1.2 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(F)c3)c(F)c2)c1 CHEMBL4109833 IC50 1.2 nM
CN1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CC1=O CHEMBL3949682 IC50 1.2 nM
O=C1NCCc2[nH]c(-c3ccnc(NC4CCOCC4)n3)cc21 CHEMBL4080944 IC50 1.2 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)C(=O)N(C(CO)c3cccc(Cl)c3)C4)n2)cn1 CHEMBL4532652 IC50 1.2 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CNCc5ccccc54)ccc23)ccn1 CHEMBL3658851 IC50 1.201 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)C4CCCCC4)ncc23)ccn1 CHEMBL3663029 IC50 1.204 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CCCCO4)ncc23)ccn1 CHEMBL3658831 IC50 1.207 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL4113084 IC50 1.21 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncccc4C)ncc23)ccn1 CHEMBL3658842 IC50 1.221 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OCc3ccccc3)c2cn1)c1ccccc1 CHEMBL4113807 IC50 1.23 nM
CC(=O)N1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4111970 IC50 1.24 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H]3CN(C)C[C@H]3c3ccccc3)ncc12 CHEMBL3979074 IC50 1.25 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCCc5cccnc54)ncc23)ccn1 CHEMBL3658632 IC50 1.253 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4COc5ccccc5C4)ncc23)ccn1 CHEMBL3658829 IC50 1.253 nM
COC(C)CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3663038 IC50 1.257 nM
C[C@@H](NC(=O)c1ccc(-c2cc([C@@H]3CCC(=O)N(C)C3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL3957769 IC50 1.26 nM
Nc1ncc([C@H]2CC[C@@H](O)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL4106645 IC50 1.28 nM
C[C@]1(O)CC[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4113510 IC50 1.28 nM
Cc1cc(-c2n[nH]c3c(F)c(NC(=O)N[C@H](CO)c4ccccc4)ncc23)ccn1 CHEMBL3662999 IC50 1.282 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC[C@H](C)c4ccccc4)ncc23)ccn1 CHEMBL3663070 IC50 1.288 nM
Nc1ncc(C2CCOCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(Cl)c1 CHEMBL4114470 IC50 1.29 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccccc4Cl)ncc23)ccn1 CHEMBL3658802 IC50 1.296 nM
S=C([S-])NCCNC(=S)[S-] CHEMBL1411246 Potency 1.3 nM
c1ccc([C@@H]2CN3CCSC3=N2)cc1 CHEMBL1369896 Potency 1.3 nM
COc1ccc(CCN(C)CCC[C@@](C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC CHEMBL1401296 Potency 1.3 nM
Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C CHEMBL1205 Potency 1.3 nM
CNC(=O)Oc1cccc2ccccc12 CHEMBL46917 Potency 1.3 nM
Nc1ccc(Br)cc1 CHEMBL57376 Potency 1.3 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1cccc(Cl)c1 CHEMBL3409574 Ki 1.3 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1cccc(F)c1 CHEMBL3409575 Ki 1.3 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cnco2)cc1F CHEMBL3910050 IC50 1.3 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H](C)O)ncc12 CHEMBL4111428 IC50 1.3 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](COC(F)F)c3ccccc3)ncc12 CHEMBL4109298 IC50 1.3 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OCc3ccccn3)c2cn1)c1ccccc1 CHEMBL4113761 IC50 1.3 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@H]3CCOC3)c2cn1)c1ccccc1 CHEMBL3912912 IC50 1.3 nM
Cc1nc(NC(=O)N[C@@H](c2ccc(F)cc2)C(C)(C)O)cc2[nH]nc(N3CCC3)c12 CHEMBL3948377 IC50 1.3 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc3c2c(n1)CCN3)c1ccccc1 CHEMBL3976981 IC50 1.3 nM
Nc1n[nH]c2c(F)c(NC(=O)N[C@H](COC(F)F)c3ccccc3)ncc12 CHEMBL4109226 IC50 1.3 nM
CC(Nc1n[nH]c2cc(NC(=O)N[C@H](COC(F)F)c3ccccc3)ncc12)C(F)(F)F CHEMBL4106792 IC50 1.3 nM
C[C@@H](NC(=O)c1ccc(-c2cc([C@H]3CCC(=O)N(C)C3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL3921309 IC50 1.3 nM
COc1cccc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ccc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)c1 CHEMBL4847212 IC50 1.3 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CNC4)ncc23)ccn1 CHEMBL3663039 IC50 1.301 nM
CO[C@H](C)CNC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3663082 IC50 1.302 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4csc5ccccc45)ncc23)ccn1 CHEMBL3662958 IC50 1.309 nM
Nc1ncc(N2CCOCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4113787 IC50 1.31 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc(-c5ncc[nH]5)c4)ncc23)ccn1 CHEMBL3658736 IC50 1.328 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(S(C)(=O)=O)cc3)c2cn1)c1ccccc1 CHEMBL3654740 IC50 1.333 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4c5ccccc5CC4O)ncc23)ccn1 CHEMBL3658699 IC50 1.336 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccn4ncnc4c3)c2cn1)c1ccc(F)cc1 CHEMBL3658668 IC50 1.344 nM
CCC(NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccn1 CHEMBL3658712 IC50 1.344 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4ccc(F)nc4)ncc23)ccn1 CHEMBL3662955 IC50 1.344 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCN(S(C)(=O)=O)c5ccccc54)ncc23)ccn1 CHEMBL3658647 IC50 1.348 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCc5nc(N)sc5C4)ncc23)ccn1 CHEMBL3662960 IC50 1.356 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncc[nH]4)ncc23)ccn1 CHEMBL3658790 IC50 1.359 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3)c2cn1)c1ccccc1 CHEMBL3654790 IC50 1.378 nM
Cn1cc(C(NC(=O)N2CCc3cnc(NC4CCOCC4)nc3C2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3892311 IC50 1.4 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3906062 IC50 1.4 nM
Cn1ccc([C@@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2ccc(Cl)c(F)c2)n1 CHEMBL3964771 IC50 1.4 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(N[C@@H]4CCO[C@H](CO)C4)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL4110007 IC50 1.4 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cnnn2C)cc1F CHEMBL3916014 IC50 1.4 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)ncc12 CHEMBL4110848 IC50 1.4 nM
CCNc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4114040 IC50 1.4 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(Cl)cc3)C(C)(C)O)nc(CO)c12 CHEMBL3972370 IC50 1.4 nM
O=C(Nc1cc2[nH]nc(OCCO)c2cn1)N[C@H](COC(F)F)c1ccccc1 CHEMBL4109658 IC50 1.4 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccc(F)cc3)ncc12 CHEMBL4114976 IC50 1.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCc3ccncc3)c2cn1)c1ccc(F)cc1 CHEMBL4114185 IC50 1.4 nM
CC[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)OC)c2cn1)c1ccc(Cl)cc1 CHEMBL4111798 IC50 1.4 nM
CSC[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccccc1 CHEMBL4110072 IC50 1.4 nM
Nc1ncc(-c2cnoc2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4109176 IC50 1.4 nM
Cn1c(-c2ccnc(NC3CCOCC3)n2)cc2c1CCNC2=O CHEMBL4079515 IC50 1.4 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)Nc4noc5ccccc45)ncc23)ccn1 CHEMBL3658704 IC50 1.403 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CCC4)ncc23)ccn1 CHEMBL3663028 IC50 1.405 nM
Cn1cncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)c1 CHEMBL4114348 IC50 1.41 nM
Cc1nn(C)cc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)c1 CHEMBL4114858 IC50 1.41 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc5c(c4)CNC5=O)ncc23)ccn1 CHEMBL3658733 IC50 1.411 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4cscn4)ncc23)ccn1 CHEMBL3662952 IC50 1.411 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnccc4C)ncc23)ccn1 CHEMBL3662947 IC50 1.413 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](CO)c3ccccc3)ncc12 CHEMBL4107371 IC50 1.42 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CC(C)(C)OC(C)(C)C4)ncc23)ccn1 CHEMBL3658734 IC50 1.445 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCO[C@@H](C)C3)c2cn1)c1ccccc1 CHEMBL3912792 IC50 1.45 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4c4ccc(F)nc4)ncc23)ccn1 CHEMBL3654807 IC50 1.452 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4nccn4C)ncc23)ccn1 CHEMBL3658791 IC50 1.455 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1)c1ccc(F)cc1 CHEMBL3654882 IC50 1.459 nM
CC1N=CC=C1c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(F)c3)c(F)c2)c1 CHEMBL4108261 IC50 1.47 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)[C@H](C(F)F)[C@@H]4c4ccccc4)ncc23)ccn1 CHEMBL3663024 IC50 1.476 nM
CC(C)n1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(S(C)(=O)=O)c4)c(F)c3)c2)cn1 CHEMBL4110081 IC50 1.48 nM
CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)cn1 CHEMBL4113851 IC50 1.48 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCCc5ncccc54)ncc23)ccn1 CHEMBL3654887 IC50 1.489 nM
Nc1ncc(C2CCC(N)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3983287 IC50 1.49 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccccc1 CHEMBL3409571 Ki 1.5 nM
O=c1cc(-c2ccnc(N[C@H]3CCOC3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409602 Ki 1.5 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1ccc(F)c(Cl)c1 CHEMBL3409568 Ki 1.5 nM
O=C(NC(c1cn[nH]c1)c1ccc(Cl)c(F)c1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3968878 IC50 1.5 nM
CC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(OC(F)F)cc1 CHEMBL4111622 IC50 1.5 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3915594 IC50 1.5 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(Nc4ccnn4C)nc3c2)c2cncn2C)cc1F CHEMBL3944501 IC50 1.5 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2cn1)NC(CN1CCOCC1)c1ccccc1 CHEMBL3955546 IC50 1.5 nM
CNc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4109930 IC50 1.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)c(Cl)c3)nc(CO)c12 CHEMBL4108533 IC50 1.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3cccc(Cl)c3)nc(CO)c12 CHEMBL4111605 IC50 1.5 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccc(F)cc1 CHEMBL4111414 IC50 1.5 nM
COCc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(N)c12 CHEMBL4111617 IC50 1.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3CCC(F)(F)C3)c2cn1)c1ccc(F)cc1 CHEMBL3937632 IC50 1.5 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCC3)c2cn1)c1ccccc1 CHEMBL4110982 IC50 1.5 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(F)c3)ncc12 CHEMBL4113659 IC50 1.5 nM
CC(C)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4113227 IC50 1.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)OCC(F)F)c2cn1)c1ccc(F)cc1 CHEMBL3928522 IC50 1.5 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CC3CO4)c2cn1)c1ccccc1 CHEMBL3914678 IC50 1.5 nM
CNC[C@H](c1cccc(Cl)c1)N1Cc2cc(-c3nc(Nc4ccnn4C)ncc3C)cn2C1=O CHEMBL5093029 IC50 1.5 nM
COCCNC(=O)Nc1cc2[nH]nc(-c3ccnc(C4CC4)c3)c2cn1 CHEMBL3663077 IC50 1.505 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(c4ccccc4)C(F)F)ncc23)ccn1 CHEMBL3658743 IC50 1.507 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccncc4)ncc23)ccn1 CHEMBL3654862 IC50 1.51 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)NCc4cccc(Br)c4)c(F)c3)c2)cn1 CHEMBL3916284 IC50 1.52 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H]3CCCN(Cc4c(F)cccc4OC)C3)ncc12 CHEMBL4112586 IC50 1.53 nM
COc1ccnc([C@@H](C)NC(=O)Nc2cc3[nH]nc(-c4ccnc(C)c4)c3cn2)c1 CHEMBL3654857 IC50 1.533 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4ccno4)ncc23)ccn1 CHEMBL3662953 IC50 1.533 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4(c5ccccn5)CCC4)ncc23)ccn1 CHEMBL3658719 IC50 1.537 nM
O=C(NCC1CCC1)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1 CHEMBL3663044 IC50 1.54 nM
CO[C@H](C)CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3663049 IC50 1.548 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cccc(C#N)c3)c2cn1)c1ccccc1 CHEMBL3663110 IC50 1.549 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(CCN(C)C)c4ccccn4)ncc23)ccn1 CHEMBL3639575 IC50 1.558 nM
Nc1ncc(C(=O)N2CCOCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4108667 IC50 1.56 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)cc4F)ncc23)ccn1 CHEMBL3662969 IC50 1.561 nM
COC(=O)N[C@H]1CC[C@@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4112286 IC50 1.57 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4F)ncc23)ccn1 CHEMBL3658696 IC50 1.574 nM
CN1CCOC(CNC(=O)Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)C1 CHEMBL3654853 IC50 1.579 nM
Cc1c(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)cnn1C CHEMBL4108262 IC50 1.58 nM
Cc1cc(-c2n[nH]c3c(C)c(NC(=O)N[C@H](C)c4ccccc4)ncc23)ccn1 CHEMBL3654802 IC50 1.581 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4(C)CCCO4)ncc23)ccn1 CHEMBL3658825 IC50 1.584 nM
Cc1cccc(C(CO)n2ccc(-c3ccnc(NC4CCOCC4)n3)cc2=O)c1 CHEMBL3409576 Ki 1.6 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1cc2ccc(Cl)cc2[nH]1 CHEMBL3680608 IC50 1.6 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@H](C)c1ccc(Cl)c(F)c1)CC2 CHEMBL3900182 IC50 1.6 nM
COCCC(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL3892063 IC50 1.6 nM
C[C@@H](NC(=O)N1Cc2nc(NC3CCOCC3)ncc2C(F)(F)C1)c1ccc(Cl)c(Cl)c1 CHEMBL4112507 IC50 1.6 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@@H]1CN(C)C[C@H]1c1ccc(C(F)(F)F)c(F)c1)CC2 CHEMBL3909547 IC50 1.6 nM
O=C(N[C@@H](c1ccc(F)c(Cl)c1)[C@]1(F)CCNC1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3955181 IC50 1.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCC3CCOCC3)c2cn1)c1ccccc1 CHEMBL4112635 IC50 1.6 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3cccc(F)c3)nc(CO)c12 CHEMBL4110919 IC50 1.6 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(F)c3)nc(CO)c12 CHEMBL4112761 IC50 1.6 nM
COc1n[nH]c2cc(NC(=O)N[C@@H]3CN(C)C[C@H]3c3ccccc3)nc(CO)c12 CHEMBL3908114 IC50 1.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccccc1 CHEMBL4107805 IC50 1.6 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2cn1)c1ccccc1 CHEMBL4110555 IC50 1.6 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC3)c2cn1)c1ccccc1 CHEMBL3944707 IC50 1.6 nM
CC(C)CC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4113106 IC50 1.6 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3cccc(F)c3)ncc12 CHEMBL4111360 IC50 1.6 nM
CC(C)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4108919 IC50 1.6 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)OC3CCOCC3)c2cn1)c1ccc(F)cc1 CHEMBL3939104 IC50 1.6 nM
C[C@@H]1CN(c2n[nH]c3cc(NC(=O)NC(c4ccc(F)cc4)C(C)(C)O)ncc23)C[C@H](C)O1 CHEMBL3926172 IC50 1.6 nM
CN1C[C@@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CCC1=O CHEMBL3903269 IC50 1.6 nM
Cn1c(-c2ccnc(NC3CCOCC3)n2)cc2c1CCN(Cc1ccccc1)C2=O CHEMBL4103768 IC50 1.6 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)ccc2CN1Cc1cccc(Cl)c1 CHEMBL4588783 IC50 1.6 nM
CCCc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3654673 IC50 1.608 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCS(=O)(=O)c5ccccc54)ncc23)ccn1 CHEMBL3658645 IC50 1.613 nM
CCCNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3654867 IC50 1.618 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCOc4ccccc4)ncc23)ccn1 CHEMBL3658816 IC50 1.625 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccc(F)cc3)ncc12 CHEMBL4108271 IC50 1.64 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCCCc5ccccc54)ncc23)ccn1 CHEMBL3658635 IC50 1.641 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@@H]4C[C@H]4c4ccccc4)c(F)c3)c2)cn1 CHEMBL3931013 IC50 1.66 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(F)c4)c(F)c3)n2)cn1 CHEMBL4110059 IC50 1.66 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4ccc(F)cn4)ncc23)ccn1 CHEMBL3658728 IC50 1.662 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccc(F)cc1 CHEMBL4110372 IC50 1.67 nM
NC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3654685 IC50 1.676 nM
O=C(NCCC1CCOC1)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3654846 IC50 1.677 nM
C[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4111453 IC50 1.68 nM
O=c1nc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409594 Ki 1.7 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)[C@H]2C[C@H](F)CN2)cc1F CHEMBL3982835 IC50 1.7 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(-c3ccnc(CO)c3)c12 CHEMBL4114505 IC50 1.7 nM
COc1n[nH]c2cc(NC(=O)NCCCCc3ccccc3)nc(CO)c12 CHEMBL3899682 IC50 1.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCc3cccnc3)c2cn1)c1ccc(F)cc1 CHEMBL4111973 IC50 1.7 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)nc([C@@H](C)O)c12 CHEMBL4111138 IC50 1.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@@H]3CCOC3)c2cn1)c1ccccc1 CHEMBL4115535 IC50 1.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCC3CCOCC3)c2cn1)c1ccccc1 CHEMBL4115602 IC50 1.7 nM
CC(C)CNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4114162 IC50 1.7 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3cccc(F)c3)ncc12 CHEMBL4110113 IC50 1.7 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(O)c3)ncc12 CHEMBL4111297 IC50 1.7 nM
COc1cc(-c2n[nH]c3ccc(NC(=O)[C@]4(SC)CCN(CC(=O)N5CC=C(c6ccc(-c7ncn(C)n7)cc6)CC5)C4)cc23)ccn1 CHEMBL4209570 IC50 1.7 nM
Nc1ncc(-c2cn[nH]c2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4111048 IC50 1.74 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(-n4ccnn4)cc3)c2cn1)c1ccc(F)cc1 CHEMBL3658675 IC50 1.75 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C#N)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658672 IC50 1.751 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCC4=CCCC4)ncc23)ccn1 CHEMBL3654839 IC50 1.757 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C#N)c3)c2cn1)c1ccc(F)cc1 CHEMBL3654884 IC50 1.764 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccccc1 CHEMBL4107899 IC50 1.79 nM
CS(=O)(=O)c1cccc([C@@H](CO)NC(=O)c2ccc(-c3nc(C4CC4)cnc3N)cc2F)c1 CHEMBL4109398 IC50 1.79 nM
Cc1cncc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cc4)ncc23)c1 CHEMBL3658676 IC50 1.798 nM
O=c1cc(-c2ccnc(N[C@@H]3CCOC3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409601 Ki 1.8 nM
O=c1cc(-c2ccnc(NC3CCOCC3)c2)ccn1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409596 Ki 1.8 nM
O=c1cc(N2CCc3[nH]nc(-c4ccncc4)c3C2)ccn1Cc1ccc(F)cc1 CHEMBL3604854 IC50 1.8 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)NC(CCN)c1ccc(C(F)(F)F)cc1)CC2 CHEMBL3937485 IC50 1.8 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)c(F)c1)[C@H]1CCCN1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL4113502 IC50 1.8 nM
COc1n[nH]c2cc(NC(=O)/C=C(\c3ccccc3)C(C)(C)O)nc(CO)c12 CHEMBL3922885 IC50 1.8 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2cn1)N[C@@H](c1ccccc1)C1(O)CC1 CHEMBL3909230 IC50 1.8 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)C(C)(C)O)nc(CO)c12 CHEMBL3956320 IC50 1.8 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)OC)ncc12 CHEMBL3946986 IC50 1.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCC3CC3)c2cn1)c1ccccc1 CHEMBL4113754 IC50 1.8 nM
CCn1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)cn1 CHEMBL4436718 IC50 1.8 nM
COc1cc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ccc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)ccn1 CHEMBL4866448 IC50 1.8 nM
C[C@H](C(=O)N[C@H](CO)c1cc(F)cc(N2CCN(C)CC2)c1)N1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O CHEMBL4857389 IC50 1.8 nM
COc1cc(F)cc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ccc(-c4ccnc(NC5CCOCC5)n4)cc3C2=O)c1 CHEMBL4873851 IC50 1.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1 CHEMBL4538174 IC50 1.8 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCCc5ccncc54)ncc23)ccn1 CHEMBL3658633 IC50 1.801 nM
COC(=O)N1CCCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)C1 CHEMBL3909058 IC50 1.81 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1)c1ccc(Cl)cc1 CHEMBL3654708 IC50 1.842 nM
CN1CC[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)C1 CHEMBL3658684 IC50 1.845 nM
CN1C[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)[C@H](c2ccccc2)C12COC2 CHEMBL3663012 IC50 1.858 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)cc3n2)c2cnn(C)c2)cc1F CHEMBL3920757 IC50 1.86 nM
CN1CC[C@@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CC1=O CHEMBL3974478 IC50 1.87 nM
C[C@@H](NC(=O)Nc1ncc2c(OCc3cccnc3)n[nH]c2c1F)c1ccccc1 CHEMBL4109773 IC50 1.89 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)NC4CC4c4ccccc4)c(F)c3)n2)cn1 CHEMBL3986020 IC50 1.89 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CN)c1ccc(F)c(Cl)c1)CC2 CHEMBL3297855 IC50 1.9 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2nccn2C)cc1F CHEMBL3930425 IC50 1.9 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(-c3nnc(C)o3)c12 CHEMBL4106853 IC50 1.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCC(O)CO)c2cn1)c1ccccc1 CHEMBL4110670 IC50 1.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCc3cncs3)c2cn1)c1ccccc1 CHEMBL4110415 IC50 1.9 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOCC3C)c2cn1)c1ccccc1 CHEMBL4109997 IC50 1.9 nM
O=C(Nc1cc2[nH]nc(N3CC4CCC(C3)O4)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4115556 IC50 1.9 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)n2)cn1 CHEMBL4107283 IC50 1.9 nM
COCCN1C(=O)c2cc(-c3ccnc(Nc4ccnn4C)n3)[nH]c2C[C@H]1C CHEMBL4088284 IC50 1.9 nM
Cn1nccc1Nc1nccc(-c2ccc3c(c2)C(=O)N(C(CO)c2cccc(Cl)c2)C3)n1 CHEMBL4567212 IC50 1.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1)c1ccc(F)c(Cl)c1 CHEMBL3654732 IC50 1.907 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3cccc(F)c3)c(F)c2)c1 CHEMBL4115445 IC50 1.91 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(N4CCOCC4)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658651 IC50 1.911 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncc(F)cc4F)ncc23)ccn1 CHEMBL3658813 IC50 1.912 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc(C)n4)ncc23)ccn1 CHEMBL3658683 IC50 1.934 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnoc4)ncc23)ccn1 CHEMBL3658800 IC50 1.949 nM
CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(F)c4)c(F)c3)c2)cn1 CHEMBL4112674 IC50 1.95 nM
C[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@@H](O)CC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4110675 IC50 1.95 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3)c2cn1)c1ccccc1 CHEMBL3654676 IC50 1.956 nM
Cc1cc(-c2n[nH]c3cc(NC(N)=O)ncc23)ccn1 CHEMBL3654674 IC50 1.997 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4nc5ccccc5[nH]4)ncc23)ccn1 CHEMBL3658772 IC50 1.999 nM
O=C(N[C@H](CO)c1ccc(F)c(Cl)c1)c1cc(-c2n[nH]cc2-c2cccc(Cl)c2)c[nH]1 CHEMBL387385 Ki 2.0 nM
C=C(C)COc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)/C(=N/O)C[C@@H]12 CHEMBL2068217 Potency 2.0 nM
COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1 CHEMBL1256786 Potency 2.0 nM
C[C@]12N[C@H](Cc3ccccc31)c1ccccc12 CHEMBL284237 Potency 2.0 nM
CCOP(=S)(OCC)Oc1ccc([N+](=O)[O-])cc1 CHEMBL261919 Potency 2.0 nM
CC[C@H](O)[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(F)c(Cl)c1 CHEMBL3297852 IC50 2.0 nM
O=C(N[C@H](CO)c1ccc(F)c(Cl)c1)N1CCc2cnc(N[C@H]3CC[C@H](O)C3)nc2C1 CHEMBL3298417 IC50 2.0 nM
C[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc2cc[nH]c2c1 CHEMBL3298983 IC50 2.0 nM
C[C@@H](NC(=O)N1CCc2cnc(N[C@H]3CCO[C@@H](CO)C3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL3298199 IC50 2.0 nM
CC[C@@H](NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL3298310 IC50 2.0 nM
CC[C@@H](NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1)c1ccc(OC)c(Cl)c1 CHEMBL3298312 IC50 2.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3ccncc3)nc2n1 CHEMBL3671095 IC50 2.0 nM
COc1ncccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1 CHEMBL3671099 IC50 2.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3cnn(CCCO)c3)nc2n1 CHEMBL3671100 IC50 2.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3cnn(CC(F)F)c3)nc2n1 CHEMBL3671101 IC50 2.0 nM
CC(CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3cnn(C)c3)nc2n1 CHEMBL3671102 IC50 2.0 nM
Cn1ccc([C@@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(Cl)c(F)c2)n1 CHEMBL3912619 IC50 2.0 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@H](C)C4CC4)nc3c2)[C@H]2CCCN2)cc1F CHEMBL4109647 IC50 2.0 nM
C[C@@H]1CC[C@H]([C@@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(Cl)c(F)c2)N1 CHEMBL4112844 IC50 2.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@@H]4CCOC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL4111472 IC50 2.0 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2cn1)N[C@@H](c1ccccc1)C1(O)CCC1 CHEMBL4115336 IC50 2.0 nM
COc1cc([C@@H](C)NC(=O)Nc2cc3[nH]nc(OC)c3c(CO)n2)ccc1Cl CHEMBL4111415 IC50 2.0 nM
O=C(Nc1cc2[nH]nc(OC[C@@H](O)C(F)(F)F)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4111496 IC50 2.0 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CC3)ncc12 CHEMBL3911883 IC50 2.0 nM
CNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H]3CCCO3)ncc12 CHEMBL3925227 IC50 2.0 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(C)c3)ncc12 CHEMBL4111832 IC50 2.0 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)NCc3ccccc3OC)ncc12 CHEMBL3940565 IC50 2.0 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)ncc12 CHEMBL4109599 IC50 2.0 nM
COc1cc(F)cc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ccc(-c4nc(Nc5cnn(C)n5)ncc4Cl)cc3C2=O)c1 CHEMBL4869800 IC50 2.0 nM
Cc1cnc(NC2CCOCC2)nc1-n1cnc(C(=O)N[C@H](CN)c2cc(F)cc(Cl)c2)c1 CHEMBL4650280 IC50 2.0 nM
Nc1ncc(-c2ccc(=O)[nH]c2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1 CHEMBL3939882 IC50 2.02 nM
Nc1ncc(C(=O)N2CC(O)C2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4113351 IC50 2.02 nM
C[C@@H](NC(=O)c1ccc(-c2cc(C3CC3)cnc2N)cc1F)c1cc(F)cc(S(C)(=O)=O)c1 CHEMBL4108734 IC50 2.03 nM
C[C@@H]1COCCN1c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)c1 CHEMBL4114173 IC50 2.05 nM
CC(C)n1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)cn1 CHEMBL4109264 IC50 2.06 nM
Cn1cc(-c2n[nH]c3cc(NC(=O)NCC4CCC4)ncc23)cn1 CHEMBL3663043 IC50 2.061 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCC(=O)Nc4ccccc4Br)ncc23)ccn1 CHEMBL3658763 IC50 2.065 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCSc5ccccc54)ncc23)ccn1 CHEMBL3658634 IC50 2.079 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)NCc1ccc(Cl)c(Cl)c1)CC2 CHEMBL3910497 IC50 2.1 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)c(F)c1)[C@@H]1CCCN1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3918026 IC50 2.1 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(N[C@@H]4CCOC[C@H]4F)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL4108506 IC50 2.1 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(Nc4ccnn4C)nc3c2)c2cnn(C)c2)cc1F CHEMBL3964791 IC50 2.1 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(Nc4cc(C)nn4C)nc3c2)c2cnn(C)c2)cc1F CHEMBL3907361 IC50 2.1 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(CO)c12 CHEMBL4110278 IC50 2.1 nM
COc1n[nH]c2cc(NC(=O)NC(c3ccc(F)c(F)c3)C(C)(C)O)nc(CO)c12 CHEMBL3929819 IC50 2.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@H]3CCOC3)c2cn1)c1ccccc1 CHEMBL4111705 IC50 2.1 nM
CNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@H]3CCCO3)ncc12 CHEMBL4113181 IC50 2.1 nM
CCNc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)ncc12 CHEMBL3915593 IC50 2.1 nM
CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2n1)c1ccc(OC)c(F)c1 CHEMBL4112587 IC50 2.1 nM
COc1cccc([C@@H](C)NC(=O)CN2Cc3ccc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)c1 CHEMBL4207147 IC50 2.1 nM
CO[C@@]1(C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL3645233 IC50 2.1 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CC4)ncc23)ccn1 CHEMBL3654686 IC50 2.102 nM
COCCNC(=O)Nc1cc2[nH]nc(-c3ccc(OC(C)C)nc3)c2cn1 CHEMBL3663078 IC50 2.124 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4nccs4)ncc23)ccn1 CHEMBL3658799 IC50 2.141 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCOC(C)C)ncc23)ccn1 CHEMBL3658814 IC50 2.144 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3)c2cn1)c1ccc(F)cc1 CHEMBL3654788 IC50 2.149 nM
COCC(NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccn1 CHEMBL3658713 IC50 2.164 nM
Cc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(OCCO)c12 CHEMBL4113414 IC50 2.17 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4108067 IC50 2.18 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccn(C)n3)c2cn1)c1ccccc1 CHEMBL3654741 IC50 2.188 nM
COCCNC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3663080 IC50 2.194 nM
Cc1cnc(NC2CCOCC2)nc1-c1ccn(C(CO)c2ccc(Cl)c(F)c2)c(=O)c1 CHEMBL3409598 Ki 2.2 nM
COC(=O)c1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)ccn1 CHEMBL3680610 IC50 2.2 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)NC(CCC#N)c1ccc(Cl)c(Cl)c1)CC2 CHEMBL3900510 IC50 2.2 nM
C[C@H](Cc1ccc(Cl)cc1)NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1 CHEMBL4111076 IC50 2.2 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2ccnn2C)cc1F CHEMBL3983706 IC50 2.2 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)cc3)nc(CO)c12 CHEMBL4112402 IC50 2.2 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)c(Cl)c3)C(C)(C)O)nc(CO)c12 CHEMBL3924000 IC50 2.2 nM
CCOc1n[nH]c2c(F)c(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL4114644 IC50 2.2 nM
CCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H](O)COC)ncc12 CHEMBL3904162 IC50 2.2 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H](C)O)nc(CO)c12 CHEMBL4110228 IC50 2.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCC3CCC3)c2cn1)c1ccccc1 CHEMBL4107054 IC50 2.2 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](CC)c3ccc(Cl)cc3)ncc12 CHEMBL4112332 IC50 2.2 nM
COCC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4114512 IC50 2.2 nM
C[C@H](Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12)C(F)F CHEMBL4107882 IC50 2.2 nM
CC(Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12)C(F)(F)F CHEMBL4110712 IC50 2.2 nM
COc1cccc(F)c1CN1CCC[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccc(F)cc4)c3cn2)C1 CHEMBL3663096 IC50 2.201 nM
O=C1c2cc(-c3ccnc(N[C@H]4CC[C@@H](O)C4)n3)cn2CCCN1[C@H](CO)c1ccccc1 CHEMBL3608460 IC50 2.26 nM
COc1cccc(F)c1CN1CCC[C@@H](NC(=O)Nc2cc3[nH]nc(-c4ccc(C#N)cc4)c3cn2)C1 CHEMBL3663097 IC50 2.265 nM
O=C(Nc1cc2[nH]nc(C3CC3)c2cn1)NC1CCCOc2ccccc21 CHEMBL3654783 IC50 2.277 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(Nc4ccnn4C)cc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3976074 IC50 2.29 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1cccc(C(F)(F)F)c1 CHEMBL3409577 Ki 2.3 nM
COc1ccc(NC(=O)COc2ccc(/C=C3\N=C(c4ccccc4)N(c4ccc(OC)cc4)C3=O)cc2)cc1 CHEMBL3577642 IC50 2.3 nM
CNC[C@@H](NC(=O)N1CCc2cnc(Nc3ccc(F)cc3)nc2C1)c1ccc(C(F)(F)F)c(F)c1 CHEMBL4109174 IC50 2.3 nM
CN1CC(NC(=O)N2CCc3cnc(NC4CCOCC4)nc3C2)[C@H](c2ccc(Cl)c(F)c2)C1 CHEMBL3967253 IC50 2.3 nM
O=C(N[C@@H](c1ccc(Cl)c(F)c1)[C@@H]1CNCCO1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3901104 IC50 2.3 nM
O=C(N[C@H](c1ccc(F)c(Cl)c1)[C@H]1CNCCO1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL4110835 IC50 2.3 nM
CCCC(NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1)c1ccc(OC)c(F)c1 CHEMBL3979810 IC50 2.3 nM
CC(C)Nc1ncc2ccc(C(=O)N[C@@H](c3ccc(C(F)(F)F)c(F)c3)[C@H]3CCCN3)cc2n1 CHEMBL4111412 IC50 2.3 nM
O=C(N[C@@H](c1ccc(Cl)c(F)c1)[C@H]1CCCN1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL4112535 IC50 2.3 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@@H](C)CO)nc3c2)c2cnn(C)c2)cc1F CHEMBL3942385 IC50 2.3 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(-c3cnco3)c12 CHEMBL4112503 IC50 2.3 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(OC)c12 CHEMBL4114281 IC50 2.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCOC3)c2cn1)c1ccccc1 CHEMBL4108259 IC50 2.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCCC3)c2cn1)c1ccccc1 CHEMBL4108127 IC50 2.3 nM
Cc1cc([C@@H](C)NC(=O)Nc2cc3[nH]nc(N)c3cn2)ccc1Cl CHEMBL4114356 IC50 2.3 nM
CC12CCC(O1)C1CN(c3n[nH]c4cc(NC(=O)N[C@@H](c5ccc(F)cc5)C(C)(C)O)ncc34)CC12 CHEMBL3947315 IC50 2.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cncnc3)c2cn1)c1ccc(F)cc1 CHEMBL3663109 IC50 2.325 nM
C[C@@H](NC(=O)N1CCc2cnc(N[C@H]3CCC(F)(F)C3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL4112182 IC50 2.33 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCc4ccccn4)ncc23)ccn1 CHEMBL3654698 IC50 2.337 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)cn4)ncc23)ccn1 CHEMBL3662972 IC50 2.346 nM
CC(C)Oc1ccc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cc4)ncc23)cn1 CHEMBL3654876 IC50 2.358 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4ccccc4OC(F)(F)F)ncc23)ccn1 CHEMBL3662979 IC50 2.39 nM
CC1CC(Nc2ncc3c(n2)CN(C(=O)N[C@H](CO)c2ccc(Cl)c(F)c2)CC3)CCO1 CHEMBL4110141 IC50 2.39 nM
CC1CC(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)CCO1 CHEMBL3409605 Ki 2.4 nM
Cc1cc(-c2ccnc(NC3CCOCC3)n2)cc(=O)n1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409593 Ki 2.4 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1cc2c(F)cccc2[nH]1 CHEMBL3680609 IC50 2.4 nM
O=C(NC(c1ccc(Cl)c(F)c1)c1nnco1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3901270 IC50 2.4 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@@H](c1ccc(Cl)c(Cl)c1)[C@H](O)CO)CC2 CHEMBL4107820 IC50 2.4 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CNc1ccncn1)c1ccc(F)c(Cl)c1)CC2 CHEMBL4107526 IC50 2.4 nM
O=C(N[C@@H](c1ccc(Cl)c(F)c1)c1nnco1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3916390 IC50 2.4 nM
O=C(N[C@@H](c1ccc(Cl)c(F)c1)c1cc[nH]n1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3958447 IC50 2.4 nM
Cc1cc(COc2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)on1 CHEMBL4115073 IC50 2.4 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)nc(C(F)F)c12 CHEMBL3918549 IC50 2.4 nM
CCOCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)ncc12 CHEMBL4111598 IC50 2.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOCC3)c2cn1)c1ccccc1 CHEMBL4106871 IC50 2.4 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3CCOCC3)c2cn1)c1ccc(F)cc1 CHEMBL3983583 IC50 2.4 nM
CCNc1n[nH]c2cc(NC(=O)NCc3c(F)cccc3OC)ncc12 CHEMBL3973755 IC50 2.4 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3cccc(Cl)c3)ncc12 CHEMBL4112219 IC50 2.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCC(F)(F)F)c2cn1)c1ccccc1 CHEMBL4107148 IC50 2.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC(O)CC3)c2cn1)c1ccccc1 CHEMBL4109704 IC50 2.4 nM
COC(C)(C)C(NC(=O)Nc1cc2[nH]nc(N3C[C@@H](C)O[C@@H](C)C3)c2cn1)c1ccc(F)cc1 CHEMBL3962565 IC50 2.4 nM
COc1cc(F)cc([C@@H](CO)N2Cc3cc(-c4nc(Nc5ccnn5C)ncc4C)cn3C2=O)c1 CHEMBL5087826 IC50 2.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3)c2cn1)c1ccc(F)cc1 CHEMBL3654771 IC50 2.433 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC[C@@H]4COCCO4)ncc23)ccn1 CHEMBL3663005 IC50 2.434 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CCC3)c2cn1)c1ccccc1 CHEMBL3654775 IC50 2.442 nM
Cc1cc(-c2n[nH]c3c(F)c(NC(=O)NC(C)c4ccccn4)ncc23)ccn1 CHEMBL3654852 IC50 2.448 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(Cl)cc4C)ncc23)ccn1 CHEMBL3662971 IC50 2.454 nM
O=C(NCC1CCOC1)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3654847 IC50 2.459 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cncc(F)c3)c2cn1)c1ccc(F)cc1 CHEMBL3663102 IC50 2.489 nM
Cc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(OC3CCOCC3)c12 CHEMBL4111846 IC50 2.49 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 2.5 nM
O=C(O)CCCN1CCCCC1 CHEMBL1401348 Potency 2.5 nM
c1ccc(-c2cc3c(nn2)CCc2nonc2-3)cc1 CHEMBL1369588 Potency 2.5 nM
C=C1[C@@H](C)[C@H]2[C@@H](Cc3ccccc3)NC(=O)[C@]23[C@H](/C=C/C[C@H](C)C(=O)[C@@](C)(O)/C=C/[C@H]3OC(C)=O)[C@@H]1O CHEMBL2373564 Potency 2.5 nM
CC1=C/C(=C(/c2ccc(O)c(C)c2)c2ccccc2C(=O)O)C=CC1=O CHEMBL1437054 Potency 2.5 nM
O=c1cc(-c2ccnc(NC3CCS(=O)(=O)C3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409606 Ki 2.5 nM
CC(CO)Nc1ncc2ccc(C(=O)NC(c3ccc(Cl)c(F)c3)c3cnn(C)c3)cc2n1 CHEMBL3898796 IC50 2.5 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(N[C@H]4CCOC[C@H]4F)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL4112774 IC50 2.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(COC(C)=O)c12 CHEMBL4106452 IC50 2.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)nc(CO)c12 CHEMBL4106935 IC50 2.5 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)NCc3ccccc3OC(F)F)ncc12 CHEMBL3984395 IC50 2.5 nM
Nc1n[nH]c2cc(NC(=O)N[C@H](CO)c3ccccc3)ncc12 CHEMBL4108350 IC50 2.5 nM
Cn1nncc1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)c1 CHEMBL4112942 IC50 2.5 nM
CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2c1)c1ccc(Cl)c(F)c1 CHEMBL4115564 IC50 2.5 nM
COCCN1CCc2[nH]c(-c3ccnc(Nc4ccnn4C)n3)cc2C1=O CHEMBL4074311 IC50 2.5 nM
C[C@H](C(=O)N[C@H](CO)c1ccccc1)N1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O CHEMBL4209691 IC50 2.5 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4c[nH]nn4)ncc23)ccn1 CHEMBL3658794 IC50 2.518 nM
COCCCc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3654672 IC50 2.534 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cn[nH]c4)ncc23)ccn1 CHEMBL3658783 IC50 2.552 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncnn4C)ncc23)ccn1 CHEMBL3658787 IC50 2.552 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCc3cccnn3)c2cn1)c1ccccc1 CHEMBL3654753 IC50 2.553 nM
C[C@]1(O)CC[C@@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4108406 IC50 2.56 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4107232 IC50 2.59 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1[C@H](COCOP(=O)(O)O)c1ccc(Cl)c(F)c1 CHEMBL3680618 IC50 2.6 nM
CS(=O)(=O)CCC(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL3923055 IC50 2.6 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@H]4CCOC[C@H]4F)nc3c2)c2cnn(C)c2)cc1F CHEMBL4110870 IC50 2.6 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(NCC3CC(C(C)(C)O)C3)c2cn1)c1ccccc1 CHEMBL4110231 IC50 2.6 nM
CC[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccc(Cl)cc1 CHEMBL4115591 IC50 2.6 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4112404 IC50 2.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CC[S+]([O-])C3)c2cn1)c1ccccc1 CHEMBL4113203 IC50 2.6 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)NC(c3ccc(Cl)c(Cl)c3)c3cnco3)ncc12 CHEMBL3905499 IC50 2.6 nM
NC[C@@H](NC(=O)c1ccc(-c2nc(C3CC3)cnc2N)cc1F)c1ccccc1 CHEMBL4111857 IC50 2.6 nM
O=C(CN1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O)N[C@@]1(CO)CCc2ccccc21 CHEMBL4868536 IC50 2.6 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4nc(C)cs4)ncc23)ccn1 CHEMBL3658839 IC50 2.614 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncccc4F)ncc23)ccn1 CHEMBL3658810 IC50 2.621 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC[C@H]4COCCO4)ncc23)ccn1 CHEMBL3663004 IC50 2.622 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(Cl)c3)c2cn1)c1ccc(F)c(Cl)c1 CHEMBL3654726 IC50 2.636 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CCN(Cc5ccccc5)C4)ncc23)ccn1 CHEMBL3658774 IC50 2.646 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3C(=O)O)c2cn1)c1ccccc1 CHEMBL3663098 IC50 2.664 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)NCc4cccc(C(F)F)c4)c(F)c3)c2)cn1 CHEMBL3889607 IC50 2.67 nM
O=C(Nc1cc2[nH]nc(C3CC3)c2cn1)N[C@@H]1CCCOc2ccccc21 CHEMBL3658663 IC50 2.675 nM
COc1ccc([C@@H]2CN(C)C[C@H]2NC(=O)c2ccc3cnc(Nc4cc(C)nn4C)cc3c2)cc1 CHEMBL3964006 IC50 2.68 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4nc(N)cs4)ncc23)ccn1 CHEMBL3658835 IC50 2.695 nM
C[C@@H](NC(=O)N1CCc2cnc(N[C@H]3CC[C@H](O)C3)nc2C1)c1ccc(C(F)(F)F)c(F)c1 CHEMBL4115625 IC50 2.7 nM
CC(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc2cc[nH]c2c1 CHEMBL3895078 IC50 2.7 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(F)c(Cl)c2)cn1 CHEMBL3946009 IC50 2.7 nM
COC(=O)[C@@H](NC(=O)Nc1cc2c(cn1)c(OC)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1 CHEMBL3895804 IC50 2.7 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(CN3CCOC3=O)c12 CHEMBL4111215 IC50 2.7 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)OC)nc(CO)c12 CHEMBL3945974 IC50 2.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC(CO)C3)c2cn1)c1ccccc1 CHEMBL4112261 IC50 2.7 nM
C[C@H]1CN(c2n[nH]c3cc(NC(=O)N[C@@H](c4ccccc4)C(C)(C)O)ncc23)C[C@H](C(F)(F)F)O1 CHEMBL3890899 IC50 2.7 nM
COC1CC(CNc2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)C1 CHEMBL4109423 IC50 2.7 nM
COCCN1CCc2c(cc(-c3ccnc(NC4CCOCC4)n3)n2C)C1=O CHEMBL4082931 IC50 2.7 nM
O=C1c2cc(-c3ccnc(NC4CCC(O)CC4)n3)ccc2CN1C(CO)c1cccc(Cl)c1 CHEMBL4458400 IC50 2.7 nM
COc1cc(F)cc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ccc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)c1 CHEMBL4847260 IC50 2.7 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cc[nH]n4)ncc23)ccn1 CHEMBL3658782 IC50 2.717 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc5ccccc5c4)ncc23)ccn1 CHEMBL3654696 IC50 2.737 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4COc5ccccc5O4)ncc23)ccn1 CHEMBL3658821 IC50 2.74 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4scnc4C)ncc23)ccn1 CHEMBL3658781 IC50 2.747 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4nccc5ccccc45)ncc23)ccn1 CHEMBL3658754 IC50 2.757 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cncs4)ncc23)ccn1 CHEMBL3658793 IC50 2.768 nM
COc1n[nH]c2cc(NC(=O)N[C@H](CO)c3ccccc3)nc(C)c12 CHEMBL4113864 IC50 2.77 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc5[nH]cnc5c4)ncc23)ccn1 CHEMBL3658732 IC50 2.794 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1[C@@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409610 Ki 2.8 nM
CN1CCC[C@@H]1[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C(F)(F)F)c(F)c1 CHEMBL4108179 IC50 2.8 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cnn(C)n2)cc1F CHEMBL3960006 IC50 2.8 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)nc(CO)c12 CHEMBL4112288 IC50 2.8 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC3)c2cn1)c1ccc(F)cc1 CHEMBL4107166 IC50 2.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)CC3CCCC3)c2cn1)c1ccccc1 CHEMBL4112029 IC50 2.8 nM
COCCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4113318 IC50 2.8 nM
O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2c1 CHEMBL4113272 IC50 2.8 nM
O=C1NCCn2cc(-c3ccnc(NC4CCOCC4)n3)cc21 CHEMBL4072622 IC50 2.8 nM
COc1cc(F)cc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ncc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)c1 CHEMBL4867689 IC50 2.8 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4(c5ccc(F)cc5)CC4)ncc23)ccn1 CHEMBL3658639 IC50 2.807 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CNC(=O)O4)ncc23)ccn1 CHEMBL3658828 IC50 2.81 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccc(F)cc1 CHEMBL4106655 IC50 2.81 nM
CC(C)n1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(F)c4)c(F)c3)c2)cn1 CHEMBL4109917 IC50 2.82 nM
Cc1ccnc(C(C)NC(=O)Nc2cc3[nH]nc(-c4ccnc(C)c4)c3cn2)c1 CHEMBL3662954 IC50 2.823 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4c(C)cc(Cl)cc4Cl)ncc23)ccn1 CHEMBL3662970 IC50 2.868 nM
O=C(NCC1CCC1)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3663020 IC50 2.877 nM
COCCNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3654691 IC50 2.897 nM
Cc1nn(C)cc1Nc1nccc(-c2ccn(C(CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL3675718 IC50 2.9 nM
C=C(c1ccc(Cl)c(F)c1)n1ccc(-c2ccnc(Nc3ccnc(C)c3)n2)cc1=O CHEMBL3675720 IC50 2.9 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@@H](c1ccc(Cl)c(Cl)c1)[C@H]1CCCN1C)CC2 CHEMBL4111564 IC50 2.9 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(Nc4ccnn4C)nc3c2)c2ccnn2C)cc1F CHEMBL3899294 IC50 2.9 nM
Cc1nccn1CCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4115530 IC50 2.9 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCCC3)nc(CO)c12 CHEMBL3977327 IC50 2.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)c3ccncc3)c2cn1)c1ccccc1 CHEMBL4110613 IC50 2.9 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)c(Cl)c3)ncc12 CHEMBL4113685 IC50 2.9 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(C)c12 CHEMBL4110273 IC50 2.9 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)nc(C)c12 CHEMBL4108681 IC50 2.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@H](C)C(F)F)c2cn1)c1ccccc1 CHEMBL4111086 IC50 2.9 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)OC3CCOC3)c2cn1)c1ccc(F)cc1 CHEMBL3978986 IC50 2.9 nM
CS(=O)(=O)N[C@H]1CC[C@@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1 CHEMBL4112936 IC50 2.9 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)ccc2CN1Cc1ccc(F)c(Cl)c1 CHEMBL4535176 IC50 2.9 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(Cl)c(C)c4)ncc23)ccn1 CHEMBL3658707 IC50 2.914 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)cc4C(F)(F)F)ncc23)ccn1 CHEMBL3662968 IC50 2.939 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncco4)ncc23)ccn1 CHEMBL3658796 IC50 2.973 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)Nc4n[nH]c5ccccc45)ncc23)ccn1 CHEMBL3662988 IC50 2.977 nM
COc1cccc(Nc2ncc(C)c(-c3c[nH]c(C(=O)N[C@H](CO)c4cccc(Cl)c4)c3)n2)c1OC CHEMBL569181 Ki 3.0 nM
CCc1ccccc1Nc1ncc(C)c(-c2c[nH]c(C(=O)N[C@H](CO)c3ccccc3)c2)n1 CHEMBL572361 Ki 3.0 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@@H](c1ccc(F)c(Cl)c1)[C@@H](C)O)CC2 CHEMBL3297850 IC50 3.0 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1)CC2 CHEMBL3357948 IC50 3.0 nM
O=C(N[C@H](CO)c1ccc(F)c(Cl)c1)N1CCc2cnc(Nc3ccc(F)cc3)nc2C1 CHEMBL3298566 IC50 3.0 nM
CC[C@@H](NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1)c1ccc(F)c(F)c1 CHEMBL3298309 IC50 3.0 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@H](C)c1ccc(C(F)(F)F)c(F)c1)CC2 CHEMBL3298311 IC50 3.0 nM
COC[C@@H](CO)Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL3409609 Ki 3.0 nM
C=CC(=O)Nc1cnccc1Nc1nc(NC2CCOCC2)ncc1Cl CHEMBL3590120 IC50 3.0 nM
O=c1cc(N2CCc3[nH]nc(-c4ccncc4)c3C2)ccn1Cc1ccccc1 CHEMBL3604847 IC50 3.0 nM
O=c1c(F)c(-c2ccnc(NC3CCOCC3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3675706 IC50 3.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3ccc(OP(=O)(O)O)cc3)nc2n1 CHEMBL3671103 IC50 3.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(N3CCOCC3)nc2n1 CHEMBL3671104 IC50 3.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3ccc(CO)cc3)nc2n1 CHEMBL3671105 IC50 3.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3cnn(CCN4CCOCC4)c3)nc2n1 CHEMBL3671106 IC50 3.0 nM
Cn1cc(-c2cnc3ccc(NC(=O)NCCCC(C)(C)c4ccccc4)nc3n2)cn1 CHEMBL3671107 IC50 3.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3cccc(C(=O)O)c3)nc2n1 CHEMBL3671125 IC50 3.0 nM
C[C@@H](CO)Nc1cc2c(cn1)CCN(C(=O)N[C@H](C)c1ccc(Cl)c(Cl)c1)C2 CHEMBL3917567 IC50 3.0 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccnn2C)cc1F CHEMBL3906653 IC50 3.0 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(SC(F)(F)F)c2cn1)c1ccccc1 CHEMBL3955438 IC50 3.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCc3ccccn3)c2cn1)c1ccc(F)cc1 CHEMBL4112785 IC50 3.0 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2c(C)n1)c1ccccc1 CHEMBL4111390 IC50 3.0 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CC3CO4)c2cn1)c1ccccc1 CHEMBL4110078 IC50 3.0 nM
Cc1cccc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ccc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)c1 CHEMBL4212211 IC50 3.0 nM
Cn1nccc1Nc1ncc(Cl)c(-c2cc3n(c2)C(=O)N([C@H](CO)c2cccc(Cl)c2)C3)n1 CHEMBL5076561 IC50 3.0 nM
CCNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3663053 IC50 3.007 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccccn4)ncc23)ccn1 CHEMBL3658841 IC50 3.024 nM
COCCC[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@H](C)c1ccc(Cl)c(Cl)c1)CC2 CHEMBL4109444 IC50 3.03 nM
Nc1cc(-c2cc(C3CCOCC3)cnc2N)ccc1C(=O)N[C@H](CO)c1ccccc1 CHEMBL4114908 IC50 3.04 nM
CCNc1n[nH]c2c(F)c(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4114034 IC50 3.05 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CN(CC(F)(F)F)C[C@H]4c4ccccc4)ncc23)ccn1 CHEMBL3658698 IC50 3.057 nM
Cc1cc(-c2n[nH]c3c(Cl)c(NC(=O)N[C@H](C)c4ccccc4)ncc23)ccn1 CHEMBL3663026 IC50 3.066 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(c4cccnc4)C(F)F)ncc23)ccn1 CHEMBL3662965 IC50 3.071 nM
Cc1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)n(C)n1 CHEMBL3675719 IC50 3.1 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(Nc4ccnn4C)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3927960 IC50 3.1 nM
C[C@@H](CO)COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3924351 IC50 3.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCC(O)CF)c2cn1)c1ccccc1 CHEMBL4113603 IC50 3.1 nM
CC(CCl)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4106529 IC50 3.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)c3cccnc3)c2cn1)c1ccccc1 CHEMBL4112941 IC50 3.1 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)NC(C)c3ccc(F)c(F)c3)ncc12 CHEMBL3893923 IC50 3.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCCC(=O)N(C)C)c2cn1)c1ccccc1 CHEMBL4107868 IC50 3.1 nM
Cc1nn(C)cc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL4114404 IC50 3.1 nM
O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)ccc2CN1C(CO)c1ccc(Cl)c(Cl)c1 CHEMBL4442577 IC50 3.1 nM
C[C@H](C(=O)N[C@H](CO)c1cccc(N2CCN(C)CC2)n1)N1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O CHEMBL4856124 IC50 3.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnc(N)nc3)c2cn1)c1ccc(F)c(Cl)c1 CHEMBL3654731 IC50 3.114 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cncc(OC)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658670 IC50 3.114 nM
COCCNC(=O)Nc1ncc2c(-c3ccnc(C4CC4)c3)n[nH]c2c1F CHEMBL3663060 IC50 3.119 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(F)c4)c(F)c3)c2)c(C#N)n1 CHEMBL4109375 IC50 3.14 nM
CCC(NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(Cl)cc1 CHEMBL3658710 IC50 3.148 nM
C[C@@H](NC(=O)N1CCc2cnc(N[C@H]3C[C@@H](O)C3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL4111664 IC50 3.15 nM
COc1cncc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cc4)ncc23)c1 CHEMBL3654879 IC50 3.162 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCC3CCCC(O)C3)c2cn1)c1ccccc1 CHEMBL3654762 IC50 3.198 nM
O=C(O)CC[C@@H](C(=O)O)N1C(=O)c2ccccc2C1=O CHEMBL1256390 Potency 3.2 nM
COc1ccc(C(C(=O)NC2CCCCC2)N2CCC3(CC2)OCCO3)cc1 CHEMBL1340207 Potency 3.2 nM
Cc1ccccc1NC(=O)C1Cc2ccccc2C(=O)O1 CHEMBL1577603 Potency 3.2 nM
O=C1/C(=C/c2cccnc2)SC(=S)N1Cc1ccco1 CHEMBL1331913 Potency 3.2 nM
CCN(CC)C(=O)N[C@H]1C[C@H]2c3cccc4[nH]cc(c34)C[C@@H]2N(C)C1 CHEMBL1315160 Potency 3.2 nM
Cc1nnc(SCC(=O)Nc2ncc3c(n2)CCCC3=O)s1 CHEMBL1573081 Potency 3.2 nM
CN1CCc2ccccc2[C@@H]1Cc1ccccc1NC(=O)c1sc2ccccc2c1Cl CHEMBL1525179 Potency 3.2 nM
CCOC(=O)C1C2NC(=O)N(Cc3ccccc3)C1(C)Oc1c(OC)cccc12 CHEMBL1485968 Potency 3.2 nM
O=C(Oc1ccccc1)c1cccc(N2C(=O)CCC2=O)c1 CHEMBL1486478 Potency 3.2 nM
COC(=O)[C@@H]1C[C@@H]2CC[C@@H](O)C[C@@H]2N1Cc1ccc(C(F)(F)F)cc1 CHEMBL1375049 Potency 3.2 nM
CCCc1cc(O)n2nc(SCc3ccccc3)nc2n1 CHEMBL1456740 Potency 3.2 nM
O=C(NCCCNC1CCCCC1)c1ccc(/C=N/O)nc1 CHEMBL3197627 Potency 3.2 nM
CN1[C@@H]2CC[C@H]1CC(NC(=O)c1nn(C)c3ccccc13)C2 CHEMBL1315374 Potency 3.2 nM
O=C(N[C@@]1(C(=O)O)C[C@@H]1c1ccccc1)c1ccccc1 CHEMBL1513334 Potency 3.2 nM
Fc1cccc(/C=N\N=C/c2cccc(F)c2)c1 CHEMBL1593191 Potency 3.2 nM
O=C(Nc1ccc2c(c1)OCO2)c1cccc2c1C(=O)N(C1CCCCC1)C2 CHEMBL1468505 Potency 3.2 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)N=C2c2ccccc2)c1 CHEMBL3577566 IC50 3.2 nM
O=c1cc(-c2ccnc(N[C@H]3CCOC[C@H]3F)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3675701 IC50 3.2 nM
CNC[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(Cl)c(F)c1 CHEMBL4108669 IC50 3.2 nM
C[C@@H](CO)Nc1ncc2c(n1)CN(C(=O)N[C@@H](c1ccc(Cl)c(Cl)c1)C(F)(F)F)CC2 CHEMBL3976530 IC50 3.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OC[C@H]3CCC(=O)N3)c2cn1)c1ccccc1 CHEMBL4113063 IC50 3.2 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)[C@@H](C)O)nc(CO)c12 CHEMBL4114003 IC50 3.2 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(Cl)c3)ncc12 CHEMBL4112109 IC50 3.2 nM
CCNc1n[nH]c2cc(NC(=O)NC(C)c3ccc(F)c(F)c3)ncc12 CHEMBL3900570 IC50 3.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1cccc(F)c1 CHEMBL4109382 IC50 3.2 nM
CN1C[C@@H](NC(=O)Nc2cc3[nH]nc(N)c3cn2)[C@H](c2ccccc2)C1 CHEMBL3938739 IC50 3.2 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(C#N)nc3)c2cn1)c1ccc(F)cc1 CHEMBL3658671 IC50 3.211 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@@H](c1ccc(F)c(Cl)c1)[C@H](C)O)CC2 CHEMBL3297851 IC50 3.23 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCC3CCO3)c2cn1)c1ccccc1 CHEMBL4111053 IC50 3.26 nM
CN1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CC1=O CHEMBL3948464 IC50 3.27 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(C#N)cc3)c2cn1)c1ccc(F)cc1 CHEMBL3654734 IC50 3.279 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC)c2c(C)n1)c1ccccc1 CHEMBL4107071 IC50 3.29 nM
CNc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccccc3)ncc12 CHEMBL4115437 IC50 3.29 nM
CS(=O)(=O)c1cccc(CNC(=O)c2ccc(-c3nc(C4CCOCC4)cnc3N)cc2)c1 CHEMBL3962596 IC50 3.29 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)c(F)cn1C(CO)c1ccc(Cl)c(F)c1 CHEMBL3409591 Ki 3.3 nM
Cc1cc(-c2ccnc(NC3CCOCC3)n2)cc(=O)n1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3675711 IC50 3.3 nM
CC(CF)Nc1ncc2c(n1)CN(C(=O)N[C@H](CO)c1ccc(Cl)c(Cl)c1)CC2 CHEMBL4112335 IC50 3.3 nM
COc1cccc(F)c1CNC(=O)Nc1cc2[nH]nc(N)c2cn1 CHEMBL3954406 IC50 3.3 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccnn4)ncc23)ccn1 CHEMBL3658809 IC50 3.301 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(Cl)cc4F)ncc23)ccn1 CHEMBL3662976 IC50 3.306 nM
Cc1noc(C)c1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)n1 CHEMBL4113158 IC50 3.32 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(F)c3)c2cn1)C1CCCCC1 CHEMBL3663045 IC50 3.336 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc(-c5ccccc5)c4)ncc23)ccn1 CHEMBL3658700 IC50 3.381 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)cc3)n2)cn1 CHEMBL4112790 IC50 3.39 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4cccc(Cl)c4)cc3)N=C2c2ccccc2)c1 CHEMBL3577634 IC50 3.4 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@H]3CCCO3)ncc12 CHEMBL4107894 IC50 3.4 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCCC3)ncc12 CHEMBL3968229 IC50 3.4 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccc(F)cc3)[C@H](C)O)nc(CO)c12 CHEMBL3970548 IC50 3.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3CC(F)(F)C3)c2cn1)c1ccc(F)cc1 CHEMBL4115638 IC50 3.4 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(C)c3)ncc12 CHEMBL4114491 IC50 3.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CCC(C3)O4)c2cn1)c1ccccc1 CHEMBL4115524 IC50 3.4 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)Cc4ccccc4)ncc23)ccn1 CHEMBL3663056 IC50 3.421 nM
O=C(NCc1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 CHEMBL3963644 IC50 3.43 nM
CCn1ncc2cc3nc(c21)CCCO[C@H](CO)[C@H](c1ccccc1)NC(=O)N3 CHEMBL3917936 IC50 3.443 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CCC3)c2cn1)c1ccc(F)cc1 CHEMBL3654774 IC50 3.459 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)C4CCC4)ncc23)ccn1 CHEMBL3663046 IC50 3.465 nM
COc1ccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccccc4Cl)cc3)N=C2c2ccccc2)cc1 CHEMBL3577643 IC50 3.5 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2cnn(C)c2)cc1C#N CHEMBL3956240 IC50 3.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(-c3cn[nH]c3)c12 CHEMBL4113512 IC50 3.5 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@H](O)CO)ncc12 CHEMBL4106855 IC50 3.5 nM
CCNc1n[nH]c2cc(NC(=O)NCc3ccccc3OC(F)F)ncc12 CHEMBL3936963 IC50 3.5 nM
Cn1nccc1Nc1nccc(-c2ccc3c(c2)C(=O)N(Cc2cccc(Cl)c2)C3)n1 CHEMBL4533640 IC50 3.5 nM
COc1cc(F)cc([C@@H](CO)NC(=O)[C@@H](C)N2Cc3ccc(-c4nc(Nc5ccnc(OC)c5)ncc4Cl)cc3C2=O)c1 CHEMBL4870176 IC50 3.5 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCOc5ccccc54)ncc23)ccn1 CHEMBL3662987 IC50 3.521 nM
CCn1ncc2cc3nc(c21)C[C@@H](O)COC[C@H](c1ccccc1)NC(=O)N3 CHEMBL3916619 IC50 3.535 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCN(CC(F)(F)F)C4)ncc23)ccn1 CHEMBL3658694 IC50 3.539 nM
Nc1ncc([C@H]2C[C@H]3COC(=O)N3C2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3955988 IC50 3.57 nM
CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](C)c4cccc(S(C)(=O)=O)c4)c(F)c3)c2)cn1 CHEMBL4114856 IC50 3.57 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4COCCO4)ncc23)ccn1 CHEMBL3658826 IC50 3.572 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CN(C)C[C@H]4C)ncc23)ccn1 CHEMBL3654833 IC50 3.588 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnoc3)c2cn1)c1ccccc1 CHEMBL3663088 IC50 3.595 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnc(N(C)S(C)(=O)=O)nc3)c2cn1)c1ccccc1 CHEMBL3658660 IC50 3.597 nM
O=C(NC(c1ccc(Cl)c(F)c1)c1ncno1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3895015 IC50 3.6 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@H]4CCOC[C@@H]4F)nc3c2)c2ccnn2C)cc1F CHEMBL3979797 IC50 3.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@@H]3COC[C@H]3F)c2cn1)c1ccccc1 CHEMBL4109529 IC50 3.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)CC3CCCCC3)c2cn1)c1ccccc1 CHEMBL4113384 IC50 3.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)Oc3ccccc3)c2cn1)c1ccccc1 CHEMBL4115058 IC50 3.6 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(C(F)(F)F)c3)ncc12 CHEMBL4108176 IC50 3.6 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)C(=O)N(Cc3cccc(Cl)c3)C4)n2)cn1 CHEMBL4476178 IC50 3.6 nM
CC1(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)CCOCC1 CHEMBL3893851 IC50 3.61 nM
COC(=O)N1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)n2)CC1 CHEMBL4112014 IC50 3.61 nM
CC(C)Oc1ccc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)cn1 CHEMBL3654679 IC50 3.628 nM
Nc1ncc(C2CCOCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1 CHEMBL4106643 IC50 3.64 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3(F)F)c2cn1)c1ccc(F)cc1 CHEMBL3654794 IC50 3.646 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnccc4C(F)(F)F)ncc23)ccn1 CHEMBL3662966 IC50 3.661 nM
COc1ccc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)cc4)ncc23)cc1 CHEMBL3663115 IC50 3.671 nM
COCC1CN(c2n[nH]c3cc(NC(=O)N[C@H](COC)c4ccccc4)ncc23)C1 CHEMBL4108217 IC50 3.7 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3C[C@H]4COC[C@H]4C3)c2cn1)c1ccc(F)cc1 CHEMBL3916081 IC50 3.7 nM
Cc1nn(C)c(C)c1-c1cnc(N)c(-c2ccc(C(=O)N[C@H](CO)c3ccccc3)c(F)c2)n1 CHEMBL4109471 IC50 3.71 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCc5ccc(F)cc54)ncc23)ccn1 CHEMBL3658640 IC50 3.726 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cncnc4)ncc23)ccn1 CHEMBL3658812 IC50 3.729 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(C#N)cc4)ncc23)ccn1 CHEMBL3658808 IC50 3.735 nM
CC(C)n1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)n2)cn1 CHEMBL4107354 IC50 3.74 nM
Nc1ncc(C2CCOCC2)cc1-c1ccc(C(=O)NCc2cccc(Cl)c2)cc1 CHEMBL3934390 IC50 3.75 nM
Nc1ncc([C@H]2C[C@H]3COC(=S)N3C2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3947263 IC50 3.77 nM
O=c1cc(-c2ccnc(N[C@H]3CCOC[C@H]3F)n2)ccn1[C@H](CO)c1ccc(Cl)c(Cl)c1 CHEMBL3675703 IC50 3.8 nM
Cn1ccc(C(NC(=O)N2CCc3cnc(NC4CCOCC4)nc3C2)c2ccc(Cl)c(F)c2)n1 CHEMBL3961291 IC50 3.8 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)NC1(c3ccc(Cl)c(Cl)c3)CCNCC1)CC2 CHEMBL3932007 IC50 3.8 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(N[C@H]4CCOC[C@@H]4F)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3912321 IC50 3.8 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@H]4C[C@H](O)C4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3937700 IC50 3.8 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@H]4C[C@@H](F)C4)nc3c2)c2cnn(OC)c2)cc1F CHEMBL3908901 IC50 3.8 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@H]4CCOC[C@H]4F)nc3c2)c2ccnn2C)cc1F CHEMBL4115373 IC50 3.8 nM
COc1n[nH]c2cc(NC(=O)N[C@H](CSC)c3ccccc3)ncc12 CHEMBL4113966 IC50 3.8 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC(F)(F)CO)ncc23)ccn1 CHEMBL3654817 IC50 3.807 nM
CCNC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3663058 IC50 3.815 nM
CCOc1n[nH]c2c(F)c(NC(=O)N[C@H](CO)c3ccccc3)ncc12 CHEMBL4109676 IC50 3.82 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCC3CCOC3)c2cn1)c1ccccc1 CHEMBL3654752 IC50 3.826 nM
CS(=O)(=O)N1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)n2)CC1 CHEMBL4109322 IC50 3.89 nM
Cc1nc[nH]c1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL3675722 IC50 3.9 nM
CCOc1n[nH]c2c(F)c(NC(=O)N[C@H](COC)c3ccc(F)cc3)ncc12 CHEMBL4108802 IC50 3.9 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H](O)CO)ncc12 CHEMBL3916027 IC50 3.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)C(C)(C)C)c2cn1)c1ccccc1 CHEMBL4108304 IC50 3.9 nM
CS(=O)(=O)c1cc(F)cc(CNC(=O)c2ccc(-c3nc(C4CC4)cnc3N)cc2F)c1 CHEMBL3970876 IC50 3.9 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cccc5ccccc45)ncc23)ccn1 CHEMBL3654683 IC50 3.92 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CNC[C@H]4F)ncc23)ccn1 CHEMBL3658693 IC50 3.959 nM
C[C@@H](NC(=O)c1ccc(-c2cc([C@H]3CCN(C)C(=O)C3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL3965624 IC50 3.98 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 3.981 nM
Cc1cnc(Nc2ccccc2O)nc1-c1c[nH]c(C(=O)N[C@H](CO)c2ccccc2)c1 CHEMBL570366 Ki 4.0 nM
Cc1cnc(Nc2ccccc2C(F)(F)F)nc1-c1c[nH]c(C(=O)N[C@H](CO)c2ccccc2)c1 CHEMBL571030 Ki 4.0 nM
CN(N=O)c1ccc(O)c(O)c1 CHEMBL1256623 Potency 4.0 nM
CC(C)NC[C@H](O)c1ccc(N)c(C#N)c1 CHEMBL1355090 Potency 4.0 nM
N=C(N)NC(=O)Cc1c(Cl)cccc1Cl CHEMBL862 Potency 4.0 nM
O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 CHEMBL15023 Potency 4.0 nM
Cn1cnc2c1c(=O)[nH]c(=O)n2C CHEMBL1114 Potency 4.0 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1)CC2 CHEMBL3297849 IC50 4.0 nM
CNC[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(F)c(Cl)c1 CHEMBL3297856 IC50 4.0 nM
O=C(N[C@H](CO)c1ccc(F)c(Cl)c1)N1CCc2cnc(NC3CCCC3)nc2C1 CHEMBL3298307 IC50 4.0 nM
O=c1cc(-c2ccnc(N[C@@H]3CCOC[C@H]3F)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3675702 IC50 4.0 nM
NC[C@H](c1ccc(Cl)c(F)c1)n1ccc(-c2ccnc(NC3CCOCC3)n2)cc1=O CHEMBL3680616 IC50 4.0 nM
CCn1cc(-c2cnc3ccc(NC(=O)NCCCCc4ccccc4)nc3n2)cn1 CHEMBL3671092 IC50 4.0 nM
Cn1cc(-c2cnc3ccc(NC(=O)NCCCCc4ccccc4)nc3n2)cn1 CHEMBL3671093 IC50 4.0 nM
CCCn1cc(-c2cnc3ccc(NC(=O)N[C@H](C)CCCc4ccccc4)nc3n2)cn1 CHEMBL3671108 IC50 4.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3cn[nH]c3)nc2n1 CHEMBL3671109 IC50 4.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3cnn(CCO)c3)nc2n1 CHEMBL3671120 IC50 4.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3cccc(C(=O)O)c3)nc2n1 CHEMBL3671123 IC50 4.0 nM
O=C(N[C@@H](c1ccc(Cl)c(F)c1)c1ccno1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3977360 IC50 4.0 nM
N#CCN1C[C@@H](NC(=O)N2CCc3cnc(NC4CCOCC4)nc3C2)[C@H](c2ccc(F)c(F)c2)C1 CHEMBL3969711 IC50 4.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@H]4CCOC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3945851 IC50 4.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NCC4COC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3971997 IC50 4.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@@H]4CCOC[C@@H]4F)nc3c2)c2cnn(C)c2)cc1F CHEMBL3977954 IC50 4.0 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCC3)ncc12 CHEMBL4113918 IC50 4.0 nM
COc1n[nH]c2cc(NC(=O)NC(C)c3ccc(F)c(F)c3)nc(CO)c12 CHEMBL3902183 IC50 4.0 nM
CN(C(=O)CN1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O)C(C)(C)C CHEMBL4210682 IC50 4.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CCCC3)c2cn1)c1ccccc1 CHEMBL3663095 IC50 4.0 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCOC4)ncc23)ccn1 CHEMBL3663031 IC50 4.005 nM
CNC[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(C(F)(F)F)c(F)c1 CHEMBL4114529 IC50 4.1 nM
O=C(N[C@H](CO)c1ccc(F)c(Cl)c1)N1CCc2cnc(N[C@H](CO)Cc3ccccc3)nc2C1 CHEMBL3924607 IC50 4.1 nM
COc1n[nH]c2cc(NC(=O)N[C@@H]3CN(C)C[C@H]3c3ccccc3)ncc12 CHEMBL3901605 IC50 4.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCOC3)c2cn1)c1ccccc1 CHEMBL4111099 IC50 4.1 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@H](C)O)nc(CO)c12 CHEMBL3959483 IC50 4.1 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC3CCC(C#N)CC3)c2cn1)c1ccccc1 CHEMBL4113415 IC50 4.1 nM
CC(Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12)C1CCOCC1 CHEMBL4106895 IC50 4.1 nM
COC[C@H](NC(=O)Nc1ncc2c(NC(C)C)n[nH]c2c1F)c1ccccc1 CHEMBL3947798 IC50 4.1 nM
C[C@@H](NC(=O)CN1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O)c1ccccc1 CHEMBL4207117 IC50 4.1 nM
Cn1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)cn1 CHEMBL4435650 IC50 4.1 nM
CCn1ncc2cc3nc(c21)CCCO[C@@H]([C@H](C)O)[C@@H](c1ccccc1)NC(=O)N3 CHEMBL3962242 IC50 4.107 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC(O)C4CCCCC4)ncc23)ccn1 CHEMBL3658753 IC50 4.107 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4115135 IC50 4.11 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cc(C)on4)ncc23)ccn1 CHEMBL3658832 IC50 4.117 nM
Nc1ncc([C@H]2C[C@H]3COCC(=O)N3C2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3931917 IC50 4.12 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@H]4CCO[C@H](CO)C4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3938831 IC50 4.2 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@H]4C[C@@H](O)C4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3970751 IC50 4.2 nM
O=C(Nc1cc2[nH]nc(OCC(F)F)c2cn1)N[C@H]1CN(CCO)C[C@@H]1c1ccccc1 CHEMBL4107953 IC50 4.2 nM
COc1n[nH]c2cc(NC(=O)NC(c3ccc(F)cc3)C(C)(C)OC)ncc12 CHEMBL3968457 IC50 4.2 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCC3CCCOC3)c2cn1)c1ccccc1 CHEMBL4106944 IC50 4.2 nM
COCCN1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O CHEMBL4217740 IC50 4.2 nM
COc1ccc(NC(=O)COc2ccc(/C=C3\N=C(c4ccccc4)N(c4cccc(OC)c4)C3=O)cc2)cc1 CHEMBL3577632 IC50 4.3 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)nc(-c3cnco3)c12 CHEMBL3944087 IC50 4.3 nM
CCOCCOc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CC3)ncc12 CHEMBL3904845 IC50 4.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)C3CCOCC3)c2cn1)c1ccccc1 CHEMBL4110414 IC50 4.3 nM
O=C(Nc1cc2[nH]nc(N3CC4CC3CO4)c2cn1)N[C@H](CO)c1ccccc1 CHEMBL4106442 IC50 4.3 nM
CC(C)(C)NC(=O)CN1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O CHEMBL4215376 IC50 4.3 nM
COC[C@H](Cc1ccccc1)NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3662950 IC50 4.339 nM
Cc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3663085 IC50 4.349 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnn(C)c4)ncc23)ccn1 CHEMBL3658784 IC50 4.35 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cc(C)on3)c2cn1)c1ccccc1 CHEMBL3663121 IC50 4.355 nM
COCCNC(=O)Nc1cc2[nH]nc(-c3ccc(C#N)cc3)c2cn1 CHEMBL3663073 IC50 4.378 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(COC)c12 CHEMBL4106587 IC50 4.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N[C@@H]3COC[C@@H]3F)c2cn1)c1ccccc1 CHEMBL4113004 IC50 4.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCCOC3)c2cn1)c1ccccc1 CHEMBL4112428 IC50 4.4 nM
O=C(Nc1cc2[nH]nc(NC(=O)N3CC(F)(F)C3)c2cn1)N[C@@H]1CCCOc2ccccc21 CHEMBL4110055 IC50 4.4 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCC4CCOC4)ncc23)ccn1 CHEMBL3658751 IC50 4.425 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CNc1ncccn1)c1ccc(F)c(Cl)c1)CC2 CHEMBL4114225 IC50 4.43 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cnc(-n4cccn4)nc3)c2cn1)c1ccccc1 CHEMBL3658659 IC50 4.437 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C4CC4)C(F)(F)F)ncc23)ccn1 CHEMBL3654692 IC50 4.482 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCC(O)C(F)F)c2cn1)c1ccccc1 CHEMBL3654754 IC50 4.486 nM
O=C(NCc1ncco1)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1 CHEMBL3654848 IC50 4.492 nM
COc1ccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)N=C2c2ccccc2)cc1 CHEMBL3577645 IC50 4.5 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@H]4C[C@H](F)C4)nc3c2)c2cnn(OC)c2)cc1F CHEMBL3940403 IC50 4.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(COCCO)c12 CHEMBL4112481 IC50 4.5 nM
COC1CCN(c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)CC1 CHEMBL4107411 IC50 4.5 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 IC50 4.5 nM
Nc1ncc([C@@H]2CCOC2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1 CHEMBL3925022 IC50 4.51 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4[C@H](CO)[C@H]5CC[C@@H]4O5)ncc23)ccn1 CHEMBL3658731 IC50 4.511 nM
CNC(=O)c1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3654767 IC50 4.536 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](COCC(F)F)c4ccccc4)ncc23)no1 CHEMBL3663138 IC50 4.569 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CNC[C@@H]4c4ccccc4)ncc23)ccn1 CHEMBL3654808 IC50 4.58 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(C#N)nc3)c2cn1)c1ccc(F)cc1 CHEMBL3654880 IC50 4.587 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)N=C2c2ccccc2)c1 CHEMBL3577635 IC50 4.6 nM
O=c1cc(N2CCc3[nH]nc(-c4ccncc4)c3C2)ccn1Cc1ccccc1Br CHEMBL3604855 IC50 4.6 nM
COc1n[nH]c2c(F)c(NC(=O)N[C@H](C)c3ccccc3)nc(CO)c12 CHEMBL4109639 IC50 4.6 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(C(F)(F)F)c3)nc(CO)c12 CHEMBL4108046 IC50 4.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCc3ccccc3)c2cn1)c1ccccc1 CHEMBL4112443 IC50 4.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)c3ccco3)c2cn1)c1ccccc1 CHEMBL4114479 IC50 4.6 nM
CC(NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1ccc(F)c(F)c1 CHEMBL3925262 IC50 4.6 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(Nc4cc(C)nn4C)cc3c2)c2cnn(C)c2)cc1F CHEMBL3969698 IC50 4.6 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCCC(Oc5cccc(F)c5)C4)ncc23)ccn1 CHEMBL3663090 IC50 4.671 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccccc4OC)cc3)N=C2c2ccccc2)c1 CHEMBL3577567 IC50 4.7 nM
C[C@@H](NC(=O)N1CCc2cnc(N[C@H](CO)Cc3ccccc3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL4114052 IC50 4.7 nM
CCOC[C@@H](NC(=O)Nc1cc2[nH]nc(OC)c2cn1)c1ccccc1 CHEMBL4111460 IC50 4.7 nM
C[C@H](Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12)c1ccccn1 CHEMBL4109594 IC50 4.7 nM
CN1C[C@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CC1=O CHEMBL3968451 IC50 4.77 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC3)c2cn1)c1ccccc1 CHEMBL4106503 IC50 4.78 nM
Nc1ncc(C2CCC(=O)NC2)nc1-c1ccc(C(=O)NCc2ccccc2)c(F)c1 CHEMBL3907795 IC50 4.79 nM
CC[C@@H](NC(=O)N1CCc2cnc(N[C@H]3CC[C@H](O)C3)nc2C1)c1ccc(C(F)(F)F)c(F)c1 CHEMBL3934429 IC50 4.8 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(Nc4ccnc(C)c4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3975792 IC50 4.8 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC3)c2cn1)c1ccccc1 CHEMBL4107828 IC50 4.8 nM
COCCN1CCc2[nH]c(-c3ccnc(NC4CCOCC4)n3)cc2C1=O CHEMBL4074437 IC50 4.8 nM
CO[C@@]1(C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)CCN(CC(=O)N2CC=C(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL3645231 IC50 4.8 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)C(=O)N([C@H](CO)c1ccc(Cl)c(F)c1)C2 CHEMBL5089637 IC50 4.8 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCF)ncc23)ccn1 CHEMBL3654826 IC50 4.855 nM
CNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4115316 IC50 4.87 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCN(C)C4)ncc23)ccn1 CHEMBL3663047 IC50 4.872 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3(F)F)c2cn1)c1ccccc1 CHEMBL3654791 IC50 4.89 nM
CC1COCCC1Oc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4113385 IC50 4.9 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3CCC(F)(F)CC3)c2cn1)c1ccc(F)cc1 CHEMBL3938231 IC50 4.9 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC(c4ccccc4)N4CCCCC4)ncc23)ccn1 CHEMBL3658750 IC50 4.944 nM
Cc1cnc(Nc2ccc(Cl)cc2F)nc1-c1c[nH]c(C(=O)N[C@H](CO)c2cccc(Cl)c2)c1 CHEMBL576048 Ki 5.0 nM
Cc1cc(Cl)ccc1Nc1ncc(C)c(-c2c[nH]c(C(=O)N[C@H](CO)c3cccc(Cl)c3)c2)n1 CHEMBL568483 Ki 5.0 nM
O=C(CSc1nc2ccccc2s1)N1CCOCC1 CHEMBL1399261 Potency 5.0 nM
O=S(=O)(Nc1ccc2c(c1)nc1n2CCOC1)c1ccccc1 CHEMBL1381073 Potency 5.0 nM
CN1CCN(c2nc(-c3ccc(N(C)C)cc3)nc3ccccc23)CC1 CHEMBL1320607 Potency 5.0 nM
O=P1(Nc2ccc(Br)cn2)COc2ccccc2OC1 CHEMBL1479341 Potency 5.0 nM
Cc1ccc(C(=O)n2cnnc2N)cc1C CHEMBL1603586 Potency 5.0 nM
CCOC(=O)CN(C(=O)CSc1nnc(-c2ccncc2)n1CCCN(C)C)c1ccccc1 CHEMBL1430034 Potency 5.0 nM
CC(C)Oc1ccccc1C1CC(=O)Nc2cc3c(cc21)OCO3 CHEMBL1369033 Potency 5.0 nM
COc1cccc(NC(=O)CCS(=O)(=O)c2cccs2)c1 CHEMBL1504626 Potency 5.0 nM
OCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1 CHEMBL333985 Potency 5.0 nM
COc1cc(C(=O)OCC(=O)N(C)Cc2ccccc2)cc(OC)c1OC CHEMBL1544070 Potency 5.0 nM
Cc1cc(C(=O)COC(=O)CCCN2C(=O)c3ccccc3C2=O)c(C)n1C CHEMBL1587997 Potency 5.0 nM
CC(=O)N1CCC2(CC1)CN(c1ccccc1)C2 CHEMBL1555190 Potency 5.0 nM
O=C(O)CCSc1nc(O)c2ccccc2n1 CHEMBL1334519 Potency 5.0 nM
O=C(NC1CCCCC1)c1ccc2c(=O)n(CC3CCCO3)c(=O)[nH]c2c1 CHEMBL1490371 Potency 5.0 nM
CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1 CHEMBL1472989 Potency 5.0 nM
C=CCN(C(=O)CNC(=O)c1ccco1)C(C(=O)NC1CCCCC1)c1ccccc1 CHEMBL1427957 Potency 5.0 nM
CCCCCCNS(=O)(=O)c1ccc(OC)c(OC)c1 CHEMBL1574151 Potency 5.0 nM
CN1C(=O)CCC1c1cccnc1 CHEMBL664 Potency 5.0 nM
O=S(=O)(c1ccc(Sc2nnc3ccccn23)nc1)N1CCOCC1 CHEMBL1533142 Potency 5.0 nM
COc1ccc(S(=O)(=O)N(C)CC(=O)NCCC2=CCCCC2)cc1 CHEMBL1339059 Potency 5.0 nM
COc1cc(NC(=O)CN2CCN(c3ccccc3F)CC2)cc(OC)c1 CHEMBL1543053 Potency 5.0 nM
CCc1cnc(-c2ccc(N3CCN(C(=O)CN4CC[C@@H](C(=O)Nc5ccc(O)c(Cl)c5)C4)CC3)cc2)nc1 CHEMBL3398599 IC50 5.0 nM
O=C(Nc1ccc(O)c(C(F)(F)F)c1)[C@@H]1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL3398605 IC50 5.0 nM
O=c1cc(N2CCc3[nH]nc(-c4ccncc4)c3C2)cc[nH]1 CHEMBL3604856 IC50 5.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3cnn(CCN4CCOCC4)c3)nc2n1 CHEMBL3639699 IC50 5.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(N3CCCC3)nc2n1 CHEMBL3671110 IC50 5.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(N3CCCC3)nc2n1 CHEMBL3671111 IC50 5.0 nM
N[C@@H](Cc1ccc(-c2cnc3ccc(NC(=O)NCCCCc4ccccc4)nc3n2)cc1)C(=O)O CHEMBL3671124 IC50 5.0 nM
Cn1ccc(C(NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(Cl)c(F)c2)n1 CHEMBL3986554 IC50 5.0 nM
CC(CO)Nc1ncc2ccc(C(=O)NC(c3ccc(Cl)c(F)c3)c3ccn(C)n3)cc2n1 CHEMBL3975142 IC50 5.0 nM
COc1ccc(C(NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2cnn(CCO)c2)cc1F CHEMBL3984339 IC50 5.0 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(N)c12 CHEMBL4111994 IC50 5.0 nM
COc1cc(-c2n[nH]c3ccc(NC(=O)[C@]4(SC)CCN(CC(=O)N5CC=C(c6ccc(-c7ncccn7)cc6)CC5)C4)cc23)ccn1 CHEMBL4206960 IC50 5.0 nM
CCNc1nnc(-c2ccc(C3=CCN(C(=O)CN4CC[C@@](SC)(C(=O)Nc5ccc6[nH]nc(-c7ccc(F)cc7)c6c5)C4)CC3)cc2)o1 CHEMBL4205192 IC50 5.0 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCc5ccccc54)ncc23)ccn1 CHEMBL3654729 IC50 5.0 nM
CCn1ncc2cc3nc(c21)NCCOC[C@H](c1ccccc1)NC(=O)N3 CHEMBL3936937 IC50 5.014 nM
COCCOc1n[nH]c2cc(NC(=O)NCc3ccc(Cl)c(Cl)c3)ncc12 CHEMBL3950485 IC50 5.03 nM
CCn1ncc2cc3nc(c21)C[C@H](O)COC[C@H](c1ccc(Cl)c(F)c1)NC(=O)N3 CHEMBL3925782 IC50 5.088 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)c(C(F)(F)F)n1 CHEMBL4112276 IC50 5.13 nM
Cc1ncc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(F)c4)c(F)c3)c2)n1C CHEMBL4108272 IC50 5.14 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCCOc5ccccc54)ncc23)no1 CHEMBL3663127 IC50 5.147 nM
CNC(=O)c1cc(F)ccc1CNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 CHEMBL3662974 IC50 5.185 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)c2ccc(C(F)(F)F)c(F)c2)cn1 CHEMBL3954924 IC50 5.2 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)cc3)ncc12 CHEMBL4114633 IC50 5.2 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(OC)c3)ncc12 CHEMBL4109871 IC50 5.2 nM
CNc1n[nH]c2cc(NC(=O)N[C@H](COC)c3ccc(F)cc3)ncc12 CHEMBL4110080 IC50 5.25 nM
COc1cncc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cc4)ncc23)n1 CHEMBL3654877 IC50 5.258 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)cc3)ncc12 CHEMBL4107755 IC50 5.27 nM
CCNC(=O)c1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3654768 IC50 5.275 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC(F)F)c2cn1)c1ccccc1 CHEMBL4107419 IC50 5.29 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccccc4Cl)cc3)N=C2c2ccccc2)c1 CHEMBL3577633 IC50 5.3 nM
COCC(=O)OC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(F)c(Cl)c1 CHEMBL4108835 IC50 5.3 nM
CC[C@@H](NC(=O)Nc1cc2[nH]nc(OC)c2c(CO)n1)c1ccc(Cl)cc1 CHEMBL4113515 IC50 5.3 nM
C[C@@H](O)COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4111140 IC50 5.3 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC3C[C@@H](C)O[C@@H](C)C3)c2cn1)c1ccccc1 CHEMBL4107220 IC50 5.3 nM
Nc1n[nH]c2cc(NC(=O)NCc3ccccc3OC(F)F)ncc12 CHEMBL3926678 IC50 5.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)OCCO)c2cn1)c1ccc(F)cc1 CHEMBL4109419 IC50 5.3 nM
CN1C[C@@H](c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CC1=O CHEMBL3902203 IC50 5.32 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H](C)c4ccccn4)ncc23)ccn1 CHEMBL3654804 IC50 5.372 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cc(C)on3)c2cn1)c1ccc(F)cc1 CHEMBL3663126 IC50 5.39 nM
COc1cccc(NC(=O)COc2ccc(/C=C3\N=C(c4ccccc4)N(c4cccc(OC)c4)C3=O)cc2)c1 CHEMBL3577631 IC50 5.4 nM
C=CC(=O)Nc1ccccc1Nc1nc(NC2CCOCC2)ncc1Cl CHEMBL3590118 IC50 5.4 nM
O=C(N[C@H](c1ccc(F)c(Cl)c1)[C@H]1CCNC1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3925301 IC50 5.4 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)nc([C@@H](C)O)c12 CHEMBL4115610 IC50 5.4 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCC3CCOC3)c2cn1)c1ccccc1 CHEMBL4109539 IC50 5.4 nM
O=C1c2cc(-c3ccnc(NC4CCOC4)n3)ccc2CN1C(CO)c1cccc(Cl)c1 CHEMBL4524371 IC50 5.4 nM
N#Cc1cccc(-c2n[nH]c3cc(NC(=O)NCc4ccc(F)cc4)ncc23)c1 CHEMBL3663111 IC50 5.41 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCc5ccncc5C4)ncc23)ccn1 CHEMBL3658764 IC50 5.418 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncn[nH]4)ncc23)ccn1 CHEMBL3658785 IC50 5.419 nM
CN1CC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)c2)CC1=O CHEMBL3930173 IC50 5.44 nM
Nc1ncc(C2CC[S+]([O-])CC2)cc1-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 CHEMBL3910171 IC50 5.44 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCc3nc4ccncc4[nH]3)c2cn1)c1ccccc1 CHEMBL3654748 IC50 5.473 nM
CC[C@@H](CO)Nc1nccc(-c2ccn(C(C)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL3675715 IC50 5.5 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCCN3CCCC3=O)c2cn1)c1ccccc1 CHEMBL4109803 IC50 5.5 nM
COc1n[nH]c2cc(NC(=O)N[C@H](COC(F)F)c3ccccc3)ncc12 CHEMBL4106604 IC50 5.5 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC(O)C3)c2cn1)c1ccccc1 CHEMBL4109554 IC50 5.5 nM
C[C@H]1Cc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3[nH]nc(c23)N1 CHEMBL3892059 IC50 5.5 nM
O=C(Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1)[C@@H]1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL4225841 IC50 5.5 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(-n4ccnn4)cc3)c2cn1)c1ccc(F)cc1 CHEMBL3654868 IC50 5.54 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cnccn4)ncc23)ccn1 CHEMBL3654699 IC50 5.577 nM
CCOc1cc(Nc2ncc3c(n2)CN(C(=O)N[C@H](C)c2ccc(Cl)c(Cl)c2)CC3)ccn1 CHEMBL4111054 IC50 5.6 nM
C[C@@H](NC(=O)N1CCc2cnc(NC(CO)CO)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL4107495 IC50 5.6 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CC(F)(F)C4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3954080 IC50 5.6 nM
C[C@@H](CO)Nc1ncc2c(F)cc(C(=O)N[C@@H](c3cccc(F)c3)c3cnn(C)c3)cc2n1 CHEMBL3905399 IC50 5.6 nM
C[C@@H](O)[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4scnc4C3)c2cn1)c1ccccc1 CHEMBL4111999 IC50 5.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N)c2cn1)c1cccc(Cl)c1 CHEMBL4113863 IC50 5.6 nM
CCNC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4110533 IC50 5.6 nM
CS[C@@]1(C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL4215228 IC50 5.6 nM
Cn1nccc1Nc1nccc(-c2ccc3c(c2)C(=O)N(Cc2ccc(Cl)c(F)c2)C3)n1 CHEMBL4547563 IC50 5.6 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ncon4)ncc23)ccn1 CHEMBL3658789 IC50 5.665 nM
C[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4107711 IC50 5.68 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CNC(c5ccccc5)C4)ncc23)ccn1 CHEMBL3658773 IC50 5.693 nM
CCn1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)c(C)n1 CHEMBL3675721 IC50 5.7 nM
O=C(NCc1ccc2cc[nH]c2c1)N1CCc2cnc(NC3CCOCC3)nc2C1 CHEMBL3907666 IC50 5.7 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)[C@@H]3CCCO3)ncc12 CHEMBL3944883 IC50 5.7 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CC(=O)Nc5ccccc54)ncc23)ccn1 CHEMBL3658771 IC50 5.725 nM
Cc1ncc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2)n1C CHEMBL4113750 IC50 5.78 nM
COc1n[nH]c2cc(NC(=O)N[C@H]3CN(C)C[C@@H]3c3ccccc3C)ncc12 CHEMBL4106811 IC50 5.8 nM
COc1n[nH]c2cc(NC(=O)N[C@@H]3CCCOc4ccccc43)ncc12 CHEMBL4113191 IC50 5.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCc4scnc4C3)c2cn1)c1ccc(F)cc1 CHEMBL4108522 IC50 5.8 nM
CC1=NOC(CNc2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)C1 CHEMBL4112098 IC50 5.8 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)NC3CNc4ccccc4C3)ncc12 CHEMBL3947047 IC50 5.8 nM
O=C(CN1CCC(CF)(C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)C1)N1CCN(c2ccc(-c3ncccn3)cc2)CC1 CHEMBL4225054 IC50 5.8 nM
O=C(NOCCO)c1cc(CN2OCCCC2=O)c(F)c(F)c1Nc1ccc(I)cc1F CHEMBL1614766 IC50 5.8 nM
O=C(CN1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O)N1CCc2ccccc2CC1 CHEMBL4850133 IC50 5.8 nM
O=C1N([C@H](CO)c2cccc(Cl)c2)Cc2cc(-c3nc(NC4CCOCC4)ncc3Cl)cn21 CHEMBL5082830 IC50 5.8 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc2c(c1)OCCN(Cc1ccccc1)C2=O CHEMBL3941320 IC50 5.81 nM
[N-]=[N+]=NC[C@@H](NC(=O)c1ccc(-c2nc([C@H]3CC[C@@H](O)CC3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL4110151 IC50 5.81 nM
O=C(Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1)NC1CCOC1 CHEMBL3663059 IC50 5.83 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4csc5ccc(Cl)cc45)ncc23)ccn1 CHEMBL3658850 IC50 5.853 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)CC4CCCO4)ncc23)ccn1 CHEMBL3654865 IC50 5.883 nM
COc1n[nH]c2cc(NC(=O)N[C@@H]3CCCN(Cc4ccccc4F)C3)ncc12 CHEMBL4109731 IC50 5.9 nM
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCCC(F)(F)F)c2cn1)c1ccccc1 CHEMBL3930520 IC50 5.9 nM
C[C@@H]1Cc2nc(NC(=O)N[C@H](C)c3ccccc3)cc3[nH]nc(c23)N1 CHEMBL4112579 IC50 5.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)C3CCCCC3)c2cn1)c1ccccc1 CHEMBL4111343 IC50 5.9 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)C(=O)N([C@H](CO)c1cccc(Cl)c1)C2 CHEMBL5070887 IC50 5.9 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CC(C)(C)Oc5ccccc54)ncc23)ccn1 CHEMBL3658641 IC50 5.934 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CN(C)CCO4)ncc23)ccn1 CHEMBL3654825 IC50 5.949 nM
O=C(NCCc1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 CHEMBL3903344 IC50 5.95 nM
NC1=N/C(=C2\CCNC(=O)c3[nH]c(Br)cc32)C(=O)N1 CHEMBL359106 IC50 6.0 nM
NC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(Br)cc32)N1 CHEMBL361708 IC50 6.0 nM
O=C(NC(CO)c1ccc(F)c(Cl)c1)c1cc(-c2[nH]ncc2-c2cccc(Cl)c2)c[nH]1 CHEMBL220054 Ki 6.0 nM
Cn1cc(Nc2ncc3c(n2)CN(C(=O)N[C@H](CO)c2ccc(F)c(Cl)c2)CC3)cn1 CHEMBL3298676 IC50 6.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3ccc(O)c(F)c3)nc2n1 CHEMBL3671112 IC50 6.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(-c3cccc(CO)c3)nc2n1 CHEMBL3671113 IC50 6.0 nM
O=C(NCCCCc1ccccc1)Nc1ccc2ncc(N3CCOCC3)nc2n1 CHEMBL3671114 IC50 6.0 nM
Cc1n[nH]c(C)c1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1 CHEMBL3671115 IC50 6.0 nM
COc1ccc(-c2cnc3ccc(NC(=O)NCCCCc4ccccc4)nc3n2)cc1OC CHEMBL3671116 IC50 6.0 nM
COc1ccccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1 CHEMBL3671117 IC50 6.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3cnn(C)c3)nc2n1 CHEMBL3671118 IC50 6.0 nM
C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(-c3cccc(CO)c3)nc2n1 CHEMBL3671119 IC50 6.0 nM
CCNC(=O)Nc1ccc2ncc(-c3ccc(O)cc3)nc2n1 CHEMBL3695617 IC50 6.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NCC4CC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3961015 IC50 6.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4(C)COC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3947003 IC50 6.0 nM
Nc1n[nH]c2cc(NC(=O)NC3CCCC3c3ccccc3)ncc12 CHEMBL3978252 IC50 6.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC4CC3CO4)c2cn1)c1ccccc1 CHEMBL4112185 IC50 6.0 nM
CCNc1ncc(-c2ccc(C3=CCN(C(=O)CN4CC[C@@](SC)(C(=O)Nc5ccc6[nH]nc(-c7ccnc(C)c7)c6c5)C4)CC3)cc2)s1 CHEMBL4216900 IC50 6.0 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)C(=O)N([C@H](CO)c1cccc(Cl)c1)CC2 CHEMBL5092545 IC50 6.0 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(Cl)cn4)ncc23)ccn1 CHEMBL3658840 IC50 6.012 nM
COCCOC[C@@H](NC(=O)Nc1cc2[nH]nc(C(F)F)c2cn1)c1ccccc1 CHEMBL3663131 IC50 6.029 nM
Cc1ccc(C(C)NC(=O)Nc2cc3[nH]nc(-c4ccnc(C)c4)c3cn2)nc1 CHEMBL3658705 IC50 6.078 nM
COCCNC(=O)Nc1cc2[nH]nc(-c3ccccc3)c2cn1 CHEMBL3663075 IC50 6.09 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(C#N)cc3)c2cn1)c1cccc(Cl)c1 CHEMBL3654735 IC50 6.107 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(CO)c2cn1)c1ccccc1 CHEMBL3663064 IC50 6.162 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)NCc2ccccc2)c(F)c1 CHEMBL3955810 IC50 6.17 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCCC(O)C4)ncc23)ccn1 CHEMBL3658744 IC50 6.177 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC(C)C(F)(F)F)nc3c2)c2cnn(C)c2)cc1F CHEMBL3945348 IC50 6.2 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CCCC3)nc([C@H](C)O)c12 CHEMBL3931618 IC50 6.2 nM
N#CC1CCC(Oc2n[nH]c3cc(NC(=O)N[C@H](COC(F)F)c4ccccc4)ncc23)CC1 CHEMBL4107990 IC50 6.2 nM
Cc1cc(-c2n[nH]c3c(Cl)c(NC(=O)NCc4ccccc4)ncc23)ccn1 CHEMBL3654743 IC50 6.245 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCc4nc5ccccc5n4C)ncc23)ccn1 CHEMBL3658746 IC50 6.259 nM
CCn1ncc2cc3nc(c21)C[C@H](O)COC[C@H](c1ccc(OC)c(F)c1)NC(=O)N3 CHEMBL3934673 IC50 6.284 nM
Cn1c(COc2ccccc2)nnc1SCc1cc(O)nc2ccccc12 CHEMBL1370122 Potency 6.3 nM
CCCC1(CCC)C(=O)N=C(NCc2ccccc2)NC1=O CHEMBL1488889 Potency 6.3 nM
COC1C=CC23c4cc5c(cc4CN(CC2O)C3C1)OCO5 CHEMBL1551610 Potency 6.3 nM
Cn1cnnc1SCC(=O)N1CCC(Cc2ccccc2)CC1 CHEMBL1301577 Potency 6.3 nM
CC1CCCCC1NC(=O)CCS(=O)(=O)c1cccc2nonc12 CHEMBL1411589 Potency 6.3 nM
CNC(=O)C1CC(=O)N(c2ccc(C)cc2)C1 CHEMBL1565612 Potency 6.3 nM
Cc1nn(Cc2ccccc2Cl)c2sc(C(=O)NCCCn3ccnc3)cc12 CHEMBL1568514 Potency 6.3 nM
O=C(OCc1nnc(-c2ccccc2)o1)C1CCN(S(=O)(=O)c2cccs2)CC1 CHEMBL1415808 Potency 6.3 nM
Cc1cc(C)nc(NC(=O)CCCC(=O)O)c1 CHEMBL1599281 Potency 6.3 nM
Cn1c(N)c(C(=O)CSc2ccc3c(c2)OCCO3)c(=O)n(C)c1=O CHEMBL1367149 Potency 6.3 nM
Cc1ccccc1N1OC2C(=O)N(c3ccc(F)cc3)C(=O)C2C1c1ccccn1 CHEMBL1421962 Potency 6.3 nM
CC(=O)N1CCc2cc(S(=O)(=O)NCCC(=O)NC3CCCc4ccccc43)ccc21 CHEMBL1455126 Potency 6.3 nM
O=C(CN(Cc1ccc(F)cc1)C(=O)c1ccco1)NCc1ccc(F)cc1 CHEMBL1306761 Potency 6.3 nM
CC(C)NC[C@H](O)c1ccc(O)c(O)c1 CHEMBL1160723 Potency 6.3 nM
CS(=O)(=O)N1CCCC(C(=O)N2CCOCC2)C1 CHEMBL1448628 Potency 6.3 nM
COC(=O)Cn1cnc2sc(C)c(S(=O)(=O)N3CCN(c4ccccc4OC)CC3)c2c1=O CHEMBL1465680 Potency 6.3 nM
CNC(=O)[C@]1(C)C[C@H]1[C@H](NC(=O)[C@]1(C)C[C@H]1[C@H](NC(=O)OCc1ccccc1)c1ccccc1)c1ccccc1 CHEMBL1450413 Potency 6.3 nM
CN1C(=O)c2ccccc2C(C(=O)NCC2CCCO2)C1c1c[nH]c2ccccc12 CHEMBL1486113 Potency 6.3 nM
O=C(NCC(c1cccnc1)N1CCN(c2ccc(F)cc2)CC1)C1CCCCC1 CHEMBL1466042 Potency 6.3 nM
CCOC(=O)c1c(NC(=O)CSc2nnnn2C)sc(CC)c1C CHEMBL1353251 Potency 6.3 nM
CC1(c2ccc3c(c2)OCO3)NC(=O)N(CC(=O)Nc2ccc(N3CCOCC3)cc2)C1=O CHEMBL1402018 Potency 6.3 nM
COc1cc2[nH]c(=O)n(CCC(=O)NC3CCCC3)c(=O)c2cc1OC CHEMBL1605483 Potency 6.3 nM
COc1ccc(N)cc1 CHEMBL295652 Potency 6.3 nM
CSCCC(C(=O)O)N1C(=O)c2ccc(C(=O)O)cc2C1=O CHEMBL258877 Potency 6.3 nM
CCCc1nc(C)c(-c2ccc(OC)c(OC)c2)c(O)n1 CHEMBL1332556 Potency 6.3 nM
C#CCN(C)CCCOc1ccc(Cl)cc1Cl CHEMBL8706 Potency 6.3 nM
CCOC(=O)c1ccc(N2C(=O)CC(N3CCC(C(=O)OCC)CC3)C2=O)cc1 CHEMBL1568540 Potency 6.3 nM
Cc1c(C(=O)O)c(O)cc2c1C(=O)c1c(O)c(O[C@H]3OC(CO)C(O)C(O)C3O)c(O)c(O)c1C2=O CHEMBL1474286 Potency 6.3 nM
COc1ccc(CC(=O)NCc2cccs2)cc1 CHEMBL1354013 Potency 6.3 nM
CC(=O)OC(C(=O)NC1CCCCC1)c1ccncc1 CHEMBL1393737 Potency 6.3 nM
CSc1nsc(SCC(=O)N2CCCc3ccccc32)n1 CHEMBL1597687 Potency 6.3 nM
Cc1ccc(S(=O)(=O)NCC2CCC(C(=O)NCCCN3CCOCC3)CC2)cc1 CHEMBL1335426 Potency 6.3 nM
CCn1nnc(NC(=O)c2ccc(C(C)(C)C)cc2)n1 CHEMBL1580578 Potency 6.3 nM
COC(=O)c1ccc(NC(=O)C(C)N2C(=O)c3ccccc3C2=O)cc1 CHEMBL1493477 Potency 6.3 nM
CN1CCN(c2ncc3nc(CCc4ccccc4)c(=O)n(Cc4ccc(F)cc4)c3n2)CC1 CHEMBL1520681 Potency 6.3 nM
CNC(=O)OCC[N+](C)(C)C CHEMBL1472561 Potency 6.3 nM
O=C(Cn1cccc1C(=O)c1ccccc1)NCc1cccnc1 CHEMBL1467517 Potency 6.3 nM
Cc1cccc(NC(=O)c2sc(NC(=O)c3ccco3)c(C#N)c2C)c1C CHEMBL1385272 Potency 6.3 nM
CC(=O)c1c(C)[nH]c(C(=O)N2CCc3ccccc32)c1C CHEMBL1585117 Potency 6.3 nM
N[C@@H]1C=CC=C(C(=O)O)C1 CHEMBL1474486 Potency 6.3 nM
Cc1ccc(NC(=O)CCNS(=O)(=O)c2ccc3c(c2)oc(=O)n3C)cc1 CHEMBL1363641 Potency 6.3 nM
O=c1cc(-c2ccnc(N[C@@H]3C[C@@H]4C[C@H]3CO4)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3675707 IC50 6.3 nM
CCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4110343 IC50 6.3 nM
C[C@H](O)COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3897629 IC50 6.3 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H]4CCOc5cc(F)ccc54)ncc23)ccn1 CHEMBL3658637 IC50 6.331 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCC3(O)CC3)c2cn1)c1ccccc1 CHEMBL3654755 IC50 6.378 nM
Nc1ncc(C2CCCCC2)nc1-c1ccc(C(=O)NCc2ccccc2)c(F)c1 CHEMBL3930360 IC50 6.38 nM
O=C(N[C@H](c1ccc(F)c(Cl)c1)[C@@H]1CCNC1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL4109538 IC50 6.4 nM
Nc1ncc(C2=CCOCC2)nc1-c1ccc(C(=O)NCc2ccccc2)c(F)c1 CHEMBL3899894 IC50 6.41 nM
CC(=O)Nc1n[nH]c2c(F)c(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4111068 IC50 6.43 nM
C[C@@H](NC(=O)Nc1ncc2c(N)n[nH]c2c1F)c1ccccc1 CHEMBL4113833 IC50 6.47 nM
COCCOc1n[nH]c2c(F)c(NC(=O)N[C@H](CO)c3ccccc3)ncc12 CHEMBL4110819 IC50 6.49 nM
CC[C@@H](NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)cc2c1)c1ccc(Cl)c(F)c1 CHEMBL4108819 IC50 6.5 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4ccc(C(F)(F)F)cc4)ncc23)ccn1 CHEMBL3654705 IC50 6.52 nM
COc1cc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cc4)ncc23)ccn1 CHEMBL3658678 IC50 6.524 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCC(F)(F)CN3CCOCC3)c2cn1)c1ccccc1 CHEMBL3654756 IC50 6.533 nM
COCCOc1n[nH]c2c(F)c(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4109644 IC50 6.56 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC(C)c4ncccc4C)ncc23)ccn1 CHEMBL3658714 IC50 6.569 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4nncs4)ncc23)ccn1 CHEMBL3658801 IC50 6.596 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)NCc1cc3ccccc3[nH]1)CC2 CHEMBL3972109 IC50 6.6 nM
COCCOC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4114515 IC50 6.6 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4(O)CCN(C)CC4)ncc23)ccn1 CHEMBL3658752 IC50 6.66 nM
CCc1c(NC(=O)N[C@H](C)c2ccccc2)ncc2c(-c3ccnc(C)c3)n[nH]c12 CHEMBL3654803 IC50 6.685 nM
O=C(N[C@@H](c1ccc(F)c(Cl)c1)[C@@H]1CCNC1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL4106550 IC50 6.7 nM
O=C(N[C@@H](c1ccc(F)c(Cl)c1)[C@H]1CCNC1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3891064 IC50 6.7 nM
CCNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)c(Cl)c3)ncc12 CHEMBL4115111 IC50 6.7 nM
CC(=O)OC1CCCC(NC(=O)Nc2cc3[nH]nc(-c4ccnc(C)c4)c3cn2)C1 CHEMBL3658745 IC50 6.712 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4C4CCCCC4)ncc23)ccn1 CHEMBL3654835 IC50 6.733 nM
CCOC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3cc(C)on3)c2cn1)c1ccccc1 CHEMBL3663135 IC50 6.779 nM
COCC[C@H](C)Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL3409607 Ki 6.8 nM
Cc1cn(C(CO)c2ccc(Cl)c(F)c2)c(=O)cc1-c1ccnc(NC2CCOCC2)n1 CHEMBL3409592 Ki 6.8 nM
COc1ccc(C(NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cnn(C)n2)cc1F CHEMBL3964330 IC50 6.8 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(Nc4cn(C)nc4C)nc3c2)c2cnn(C)c2)cc1F CHEMBL3903954 IC50 6.8 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(NC(C)=O)c12 CHEMBL4110149 IC50 6.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC3CCCCC3)c2cn1)c1ccccc1 CHEMBL4113115 IC50 6.8 nM
C=CC(=O)Nc1ccccc1Nc1nc(NC2CCOCC2)ncc1C(F)(F)F CHEMBL3590121 IC50 6.9 nM
Cc1nccc(Nc2ncc3c(n2)CN(C(=O)N[C@H](C)c2ccc(Cl)c(Cl)c2)CC3)n1 CHEMBL4114339 IC50 6.9 nM
O=C(N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)C1CNCCO1)c1ccc2cnc(NC3CCOCC3)nc2c1 CHEMBL3981301 IC50 6.9 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc([C@@H](C)O)c12 CHEMBL4110174 IC50 6.91 nM
O=C(NC(CO)c1cc(Cl)cc(Cl)c1)c1cc(-c2[nH]ncc2-c2cccc(Cl)c2)c[nH]1 CHEMBL220897 Ki 7.0 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CNS(C)(=O)=O)c1ccc(F)c(Cl)c1)CC2 CHEMBL3297858 IC50 7.0 nM
Cc1cc(Nc2ncc3c(n2)CN(C(=O)N[C@H](CO)c2ccc(F)c(Cl)c2)CC3)ccn1 CHEMBL3298677 IC50 7.0 nM
COc1ccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4cccc(Cl)c4)cc3)N=C2c2ccccc2)cc1 CHEMBL3577644 IC50 7.0 nM
Cn1cc(-c2n[nH]c3c2CN(c2ccn(Cc4ccccc4)c(=O)c2)CC3)ccc1=O CHEMBL3604846 IC50 7.0 nM
O=C(N[C@H](CO)c1cccc(Cl)c1)c1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL3797756 IC50 7.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)c2cnn(C)c2)cc1 CHEMBL3976794 IC50 7.0 nM
CS[C@@]1(C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)CCN(CC(=O)N2CC=C(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL3645235 IC50 7.0 nM
CS[C@@]1(C(=O)Nc2ccc3[nH]nc(-c4ccc(OC(C)C)nc4)c3c2)CCN(CC(=O)N2CC=C(c3ccc(-c4ncn(C)n4)cc3)CC2)C1 CHEMBL4213970 IC50 7.0 nM
Nc1ncc(C2CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)c(F)c1 CHEMBL4108906 IC50 7.04 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CCO)c1ccc(C(F)(F)F)c(F)c1)CC2 CHEMBL4112840 IC50 7.2 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(N[C@H]4CCO[C@H](CO)C4)nc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3952982 IC50 7.2 nM
COCCOc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc([C@@H](C)O)c12 CHEMBL4110097 IC50 7.2 nM
O=C1c2cc(-c3ccnc(NC4CCCCC4)n3)ccc2CN1C(CO)c1cccc(Cl)c1 CHEMBL4470800 IC50 7.2 nM
C[C@@H](CO)Nc1ncc(Cl)c(-c2cc3n(c2)C(=O)N([C@H](CO)c2cccc(Cl)c2)C3)n1 CHEMBL5073083 IC50 7.2 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCCO)ncc23)ccn1 CHEMBL3663027 IC50 7.219 nM
C[C@H](Nc1ncc2ccc(C(=O)N[C@@H](c3ccc(Cl)c(F)c3)[C@@H]3CCCN3)cc2n1)C(F)(F)F CHEMBL3896305 IC50 7.3 nM
COC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3F)ncc12 CHEMBL4108439 IC50 7.3 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)NCc4cccc(S(C)(=O)=O)c4)c(F)c3)n2)[n+](C)c1 CHEMBL4111246 IC50 7.33 nM
Nc1ncc(C2CCC(O)CC2)nc1-c1ccc(C(=O)N[C@@H]2C[C@H]2c2ccccc2)c(F)c1 CHEMBL3973228 IC50 7.33 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1cc(F)ccn1 CHEMBL3654797 IC50 7.333 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC)c2cn1)c1ccccc1 CHEMBL4115216 IC50 7.36 nM
Nc1ncc(N2CCOCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1 CHEMBL4108203 IC50 7.38 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)c(Cl)c3)nc([C@H](C)O)c12 CHEMBL4110396 IC50 7.4 nM
CC1CC(Nc2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)C(C)O1 CHEMBL4106611 IC50 7.4 nM
O=c1cc(-c2ccnc(NC(CF)CF)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 CHEMBL3409608 Ki 7.5 nM
C=CS(=O)(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL3590110 IC50 7.5 nM
C[C@@H](NC(=O)N1CCc2cnc(NC3CC(F)(F)C3)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL4109124 IC50 7.5 nM
CCC(O)COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL4112065 IC50 7.5 nM
COc1n[nH]c2cc(NC(=O)N[C@@H]3CN(C)[C@H](C(F)F)[C@H]3c3ccccc3)ncc12 CHEMBL4108519 IC50 7.6 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)NCCc2ccccc2)c(F)c1 CHEMBL3971487 IC50 7.64 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCc4cc5ccccc5cn4)ncc23)ccn1 CHEMBL3658759 IC50 7.659 nM
COCc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 CHEMBL3663050 IC50 7.678 nM
CCOc1n[nH]c2cc(NC(=O)NC(CS(C)(=O)=O)c3ccccc3)ncc12 CHEMBL3929876 IC50 7.7 nM
COCc1nc(NC(=O)N[C@H](CO)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4111402 IC50 7.7 nM
Cc1nnc(-c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)o1 CHEMBL3663119 IC50 7.701 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3(F)F)c2cn1)c1ccccc1 CHEMBL3654792 IC50 7.708 nM
C[C@@H]1C[C@H](c2cnc(N)c(-c3ccc(C(=O)NCc4cccc(S(C)(=O)=O)c4)cc3)n2)CCO1 CHEMBL4111879 IC50 7.76 nM
CNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(Cl)cc3)ncc12 CHEMBL4111742 IC50 7.8 nM
CNc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4109612 IC50 7.85 nM
N#CCSc1nnc(Cc2cccs2)n1C1CCCCC1 CHEMBL1439721 Potency 7.9 nM
CCOc1cccc(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccnc2)c1 CHEMBL1419120 Potency 7.9 nM
Fc1ccc(Cn2nnnc2CN2CCc3ccccc3C2)cc1 CHEMBL1560914 Potency 7.9 nM
C=CCc1ccc([N+](C)(C)CCC(=O)CC[N+](C)(C)c2ccc(CC=C)cc2)cc1 CHEMBL1437831 Potency 7.9 nM
COc1ccc(C(O)c2nc3ccccc3s2)cc1 CHEMBL1564619 Potency 7.9 nM
COc1ccc(CCNC(=O)C2CCN(S(=O)(=O)c3c[nH]cn3)CC2)cc1OC CHEMBL1471864 Potency 7.9 nM
COC(=O)c1ccc(CSc2nc(C(F)(F)F)c3c(c2C#N)CCC3)o1 CHEMBL1362206 Potency 7.9 nM
COC(=O)c1cc(OC)c(OC)cc1-n1cnc2cc(OC)c(OC)cc2c1=O CHEMBL1607283 Potency 7.9 nM
CCO/C(O)=C1/C(C)=NC(SCC(=O)OC)=C(C#N)C1c1ccc(C(=O)OC)cc1 CHEMBL1707911 Potency 7.9 nM
Nc1ccccc1NC(=O)c1ccccc1 CHEMBL405072 Potency 7.9 nM
O=C1CC(c2ccc(O)c(O)c2)Oc2cc(O)cc(O)c21 CHEMBL307893 Potency 7.9 nM
CCc1cc(Cl)c(OC)c(C(=O)NC[C@H]2CCN(CC)C2)c1O CHEMBL1610296 Potency 7.9 nM
CNCCCN1c2ccccc2CCc2ccccc21 CHEMBL72 Potency 7.9 nM
COc1cc2c(cc1OC)-c1cc3ccc(OC)c(OC)c3c[n+]1CC2 CHEMBL274189 Potency 7.9 nM
Nc1ncnc2c1ncn2[C@@H]1CCCO1 CHEMBL1484751 Potency 7.9 nM
COC(=O)CNC(=O)C1(C)C=CCN1C(=O)c1ccccc1 CHEMBL1372768 Potency 7.9 nM
Cc1cc(-c2n[nH]c3ccc(C(=O)NCc4c(Cl)cnc(Cl)c4Cl)cc23)ccn1 CHEMBL3797917 IC50 7.9 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(-c3ccnc(C)c3)c12 CHEMBL4114089 IC50 7.9 nM
CC(C)(NC(=O)CN1Cc2ccc(-c3nc(NC4CCOCC4)ncc3Cl)cc2C1=O)c1ccccc1 CHEMBL4206693 IC50 7.9 nM
Cc1cnccc1-c1cnc(N)c(-c2ccc(C(=O)NCc3cccc(S(C)(=O)=O)c3)cc2)n1 CHEMBL3944658 IC50 7.95 nM
CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CNCCO)c1ccc(F)c(Cl)c1)CC2 CHEMBL3297857 IC50 8.0 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC(O)C(F)(F)F)ncc23)ccn1 CHEMBL3654822 IC50 8.064 nM
C[C@@H](NC(=O)c1ccc(-c2cc(C3CCC(=O)N(C)C3)cnc2N)cc1F)c1cccc(Cl)c1 CHEMBL3949143 IC50 8.09 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OC[C@H](O)C(F)(F)F)c2cn1)c1ccccc1 CHEMBL4107602 IC50 8.1 nM
COc1n[nH]c2cc(NC(=O)N[C@H](CO)c3ccccc3)ncc12 CHEMBL4115557 IC50 8.16 nM
COc1n[nH]c2cc(NC(=O)N[C@@H]3CN(C)C[C@H]3c3ccccc3C(F)(F)F)ncc12 CHEMBL3895631 IC50 8.16 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)nc3c2)[C@H]2CCCN2)cc1F CHEMBL4111804 IC50 8.2 nM
COC[C@H](NC(=O)Nc1cc2[nH]nc(OC)c2cn1)c1ccc(F)cc1 CHEMBL3909437 IC50 8.23 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CN(C)C[C@@H]4C4CC4)ncc23)ccn1 CHEMBL3654836 IC50 8.269 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@H]4CCCOc5ccccc54)ncc23)ccn1 CHEMBL3658654 IC50 8.283 nM
CCNc1n[nH]c2cc(NC(=O)NC3CCCC3c3ccccc3)ncc12 CHEMBL3954737 IC50 8.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C(=O)NCCC3(O)CCCC3)c2cn1)c1ccccc1 CHEMBL3654757 IC50 8.333 nM
Nc1ncc(C2CCOCC2)nc1-c1ccc(C(=O)NC(c2ccccc2)C(F)F)c(F)c1 CHEMBL3974723 IC50 8.39 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(-c3nnc(C)s3)c12 CHEMBL4107493 IC50 8.4 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(Cn3ccnn3)c12 CHEMBL4113899 IC50 8.4 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(Nc3ccccc3OC)c2cn1)c1ccccc1 CHEMBL4107200 IC50 8.4 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4CCCO4)ncc23)ccn1 CHEMBL3658820 IC50 8.455 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CC(=O)Nc5ccc(F)cc54)ncc23)ccn1 CHEMBL3658760 IC50 8.465 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1cc(F)c2cc[nH]c2c1 CHEMBL3680611 IC50 8.5 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(Nc4ccnn4C)nc3c2)c2nccn2C)cc1F CHEMBL3968650 IC50 8.5 nM
COCC1CN(c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)C1 CHEMBL4108878 IC50 8.5 nM
COCCOc1n[nH]c2cc(NC(=O)NCCc3ccccc3)ncc12 CHEMBL3896770 IC50 8.51 nM
Nc1ncc(C(=O)N2CCC(O)CC2)cc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4111946 IC50 8.59 nM
COCc1nc(NC(=O)N[C@H](COC(F)F)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4115359 IC50 8.6 nM
COc1n[nH]c2cc(NC(=O)N[C@H](COC(F)F)c3ccccc3)nc(CO)c12 CHEMBL4106628 IC50 8.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NC(=O)N3CC(C)(O)C3)c2cn1)c1ccccc1 CHEMBL4109388 IC50 8.6 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCCOC4)ncc23)ccn1 CHEMBL3658830 IC50 8.616 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OC3COC3)c2cn1)c1ccccc1 CHEMBL4110018 IC50 8.66 nM
COC1CC([n+]2c[nH]c3cc(NC(=O)N[C@H](C)c4ccc(F)cc4)ncc32)C1 CHEMBL4114276 IC50 8.69 nM
O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1CCc1ccc(OC(F)(F)F)cc1 CHEMBL3675717 IC50 8.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCCn3cccn3)c2cn1)c1ccccc1 CHEMBL4111991 IC50 8.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(OCC3CC3)c2cn1)c1ccccc1 CHEMBL4114549 IC50 8.73 nM
COC1CN(c2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)C1 CHEMBL4113693 IC50 8.75 nM
Nc1ncc(C2CCOCC2)cc1-c1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1F CHEMBL4114871 IC50 8.78 nM
CCn1ncc2cc3nc(c21)CCCOC[C@H](c1ccccc1)NC(=O)N3 CHEMBL3964039 IC50 8.791 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)nc(-c3nnc(C)o3)c12 CHEMBL3946607 IC50 8.8 nM
Cc1ccc(Nc2n[nH]c3cc(NC(=O)N[C@H](C)c4ccccc4)ncc23)cn1 CHEMBL4115479 IC50 8.8 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3CC3(F)F)c2cn1)c1ccc(F)cc1 CHEMBL3654793 IC50 8.832 nM
CCc1nc(NC(=O)N[C@H](COC)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4113241 IC50 8.88 nM
COCc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4107819 IC50 8.89 nM
CNC(=O)OCc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(OC)c12 CHEMBL4110521 IC50 8.9 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(-c3ccnc(C)n3)c12 CHEMBL4109524 IC50 8.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccn(C4COC4)n3)c2cn1)c1ccccc1 CHEMBL3663086 IC50 8.989 nM
O=C(N[C@H](CO)c1ccc(F)c(Cl)c1)N1CCc2cnc(NCCO)nc2C1 CHEMBL3298306 IC50 9.0 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NC4CCOCC4)nc3c2)[C@H]2CCCN2)cc1F CHEMBL4114001 IC50 9.0 nM
CCOc1n[nH]c2c(F)c(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4110068 IC50 9.0 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1 CHEMBL296586 IC50 9.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC4(CC3)COC4)c2cn1)c1ccccc1 CHEMBL4113516 IC50 9.1 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(C3=CNCN=C3)c2cn1)c1ccc(F)cc1 CHEMBL3663101 IC50 9.132 nM
COCCOc1n[nH]c2cc(NC(=O)NC(C)c3ccc(OC)cc3)ncc12 CHEMBL3942407 IC50 9.2 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)C3CCCCC3)nc(CO)c12 CHEMBL4111589 IC50 9.2 nM
COCC(C)Oc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccc(F)cc3)ncc12 CHEMBL4107299 IC50 9.2 nM
Cc1cnc(Nc2ccnn2C)nc1-c1ccc2c(c1)CCN([C@H](CO)c1cccc(Cl)c1)C2=O CHEMBL5086221 IC50 9.2 nM
COc1ccc(C2(NC(=O)Nc3cc4[nH]nc(-c5ccnc(C)c5)c4cn3)CC2)cc1 CHEMBL3658723 IC50 9.272 nM
O=C(NCc1c(Cl)cncc1Cl)c1ccc2[nH]nc(-c3ccncc3)c2c1 CHEMBL3797242 IC50 9.3 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC)c2c(CO)n1)c1ccc(F)cc1 CHEMBL4114286 IC50 9.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(NCc3ccccn3)c2cn1)c1ccccc1 CHEMBL4109635 IC50 9.3 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(F)cc3)c2cn1)c1ccc(F)c(Cl)c1 CHEMBL3654724 IC50 9.337 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(OC)c2c(C2CC2)n1)c1ccccc1 CHEMBL4114082 IC50 9.34 nM
COc1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C3(O)CC3)ncc12 CHEMBL3954392 IC50 9.4 nM
COC[C@@H](NC(=O)Nc1cc2[nH]nc(Nc3ccccc3F)c2cn1)c1ccccc1 CHEMBL4114092 IC50 9.4 nM
CO[C@H]1CC[C@H](c2cnc(N)c(-c3ccc(C(=O)NCc4ccccc4)c(F)c3)n2)CC1 CHEMBL3964597 IC50 9.42 nM
Cc1cc(-c2n[nH]c3ccc(C(=O)N[C@@H](C)c4c(Cl)cccc4Cl)cc23)ccn1 CHEMBL3798624 IC50 9.5 nM
Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)C(=O)N([C@H](CO)c1ccc(F)c(Cl)c1)C2 CHEMBL5081036 IC50 9.5 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NC4CCOc5cc(F)ccc54)ncc23)ccn1 CHEMBL3658655 IC50 9.589 nM
COc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(Cn3ccnc3)c12 CHEMBL4110942 IC50 9.6 nM
CCNc1n[nH]c2cc(NC(=O)NCc3cccnc3OCC)ncc12 CHEMBL3983374 IC50 9.6 nM
Nc1ncc(C(=O)N2CCC(CO)CC2)nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(Br)c2)c(F)c1 CHEMBL4111027 IC50 9.68 nM
COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(N[C@H]4CC[C@@H](O)CC4)nc3c2)c2cnn(C)c2)cc1F CHEMBL3914384 IC50 9.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC(O)C3)c2cn1)c1ccccc1 CHEMBL4112310 IC50 9.7 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CCC(C#N)CC3)c2cn1)c1ccccc1 CHEMBL4113738 IC50 9.7 nM
CCO[C@@]1(C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 CHEMBL4226533 IC50 9.7 nM
Cn1cc(-c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4ccccc4)c(F)c3)c2F)cn1 CHEMBL4108568 IC50 9.77 nM
CC(=O)OC[C@H](c1ccc(Cl)c(F)c1)n1ccc(-c2ccnc(Nc3ccnn3C)n2)cc1=O CHEMBL3680614 IC50 9.8 nM
COC[C@@H](NC(=O)N1CCc2cnc(NCCO)nc2C1)c1ccc(Cl)c(Cl)c1 CHEMBL4108167 IC50 9.8 nM
Nc1ncc(C2CCOCC2)cc1-c1ccc(C(=O)NCc2cccc(C(F)(F)F)c2)cc1 CHEMBL3960210 IC50 9.8 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)N[C@@H](c4ccc(F)cc4)C(F)(F)F)ncc23)ccn1 CHEMBL3658650 IC50 9.826 nM
COC[C@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(F)cc1 CHEMBL3658691 IC50 9.826 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccc(N4CCCCC4)nc3)c2cn1)c1ccc(F)cc1 CHEMBL3654870 IC50 9.85 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccnn2C)ncc1Cl CHEMBL3590123 IC50 9.9 nM
C[C@@H](NC(=O)Nc1cc2[nH]nc(N3CC(C#N)C3)c2cn1)c1ccccc1 CHEMBL4107712 IC50 9.9 nM
Cc1cc(-c2n[nH]c3cc(NC(=O)NCC4(O)CC4)ncc23)ccn1 CHEMBL3654688 IC50 9.902 nM