CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N CHEMBL210618 IC50 0.068 nM
C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F CHEMBL4546504 IC50 0.107 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCCC3=O)cc2)ncc1Cl CHEMBL3220502 IC50 0.16 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)c(F)c2)ncc1Cl CHEMBL3220499 IC50 0.25 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl CHEMBL3220493 IC50 0.28 nM
COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 CHEMBL3220497 IC50 0.28 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2F)ncc1Cl CHEMBL3220496 IC50 0.3 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1 CHEMBL4077018 IC50 0.3 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 CHEMBL3220498 IC50 0.31 nM
NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5403678 IC50 0.379 nM
COc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 CHEMBL3220494 IC50 0.42 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)cc2)c1 CHEMBL3393608 IC50 0.5 nM
CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5423620 IC50 0.564 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)c1 CHEMBL4062023 IC50 0.6 nM
CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5411160 IC50 0.607 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4cccnc4)n3)cc2)c1 CHEMBL3393607 IC50 0.7 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5436023 IC50 0.716 nM
NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5398642 IC50 0.73 nM
N#Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 CHEMBL3220500 IC50 0.77 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5401511 IC50 0.779 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL3220495 IC50 0.78 nM
CCOc1nc(C(=O)NCc2ccccc2S(N)(=O)=O)cc(N)c1C#N CHEMBL377408 pKi 0.7943 nM
Cc1cc(NC(=O)c2cccc(NC(=O)/C=C/CN(C)C)c2)ccc1Nc1nccc(-c2cccnc2)n1 CHEMBL2216824 IC50 0.98 nM
Oc1onc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)c1-c1ccc(F)cc1 CHEMBL3099975 IC50 1.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950289 Kd apparent 1.0 nM
O=C(NC1CC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4861739 IC50 1.0 nM
[2H]C([2H])([2H])N1CC[C@H](NC(=O)c2cc(-n3ncc4cc(Nc5ccccc5Cl)ccc43)cs2)C1 CHEMBL4875508 IC50 1.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5396715 IC50 1.0 nM
CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5424946 IC50 1.08 nM
CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5429577 IC50 1.11 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(F)cc2)ncc1Cl CHEMBL3217784 IC50 1.2 nM
CCn1c(-c2ccccc2-c2ccc(C)cc2C)nc2cc(C(=O)NC)ccc21 CHEMBL4633869 Ki 1.2 nM
CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5408675 IC50 1.2 nM
CCOC(=O)C1Cc2nc(-c3ccc4c(c3)OCO4)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5431060 IC50 1.2 nM
O=C(NC1CCNCC1)c1cccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL194806 pIC50 1.259 nM
CCCn1c(C2CCN(C)CC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CC2)n1 CHEMBL252967 IC50 1.6 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 IC50 1.6 nM
NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5430858 IC50 1.72 nM
NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5399794 IC50 1.76 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CCC(O)CC3)CC2)n1 CHEMBL2425628 Kd 1.8 nM
CN(C)CCNC(=O)c1ccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)cc1 CHEMBL399167 IC50 1.9 nM
Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356001 IC50 1.9 nM
N[C@H]1CC[C@H](Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)CC1 CHEMBL3355999 IC50 1.9 nM
N#Cc1ccc2c(ccc(=O)n2CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c1 CHEMBL1822151 IC50 2.0 nM
N#Cc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 CHEMBL1822152 IC50 2.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1C CHEMBL4086457 IC50 2.0 nM
CCC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)c1 CHEMBL4069805 IC50 2.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c(C)c2)c1 CHEMBL4092555 IC50 2.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4C)ccn3)cc2)c1 CHEMBL4082278 IC50 2.0 nM
O=C(N[C@H]1CCOC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4874575 IC50 2.0 nM
O=C(NC1CCOCC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4867426 IC50 2.0 nM
CC(C)NC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4865870 IC50 2.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)c(F)cc32)cs1 CHEMBL4874573 IC50 2.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)ncc32)cs1 CHEMBL4877727 IC50 2.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)cnc32)cs1 CHEMBL4857979 IC50 2.0 nM
N#CCc1cnc(-c2ccc(Cl)c(Cl)c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5418449 IC50 2.0 nM
CCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3n2[C@H](CO)CC3)n1 CHEMBL198756 IC50 2.5 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(Cl)cc2)ncc1Cl CHEMBL3220501 IC50 2.5 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL424872 pKi 2.512 nM
NC(=O)N1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5194407 IC50 2.9 nM
CCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3n2[C@@H](CO)CC3)n1 CHEMBL383799 IC50 3.0 nM
O=C(Nc1cc(-c2ccnc(Nc3ccc(F)cc3)c2)ccn1)C1CCOC1 CHEMBL203839 IC50 3.0 nM
O=C(Nc1cc(-c2ccnc(Nc3ccc(F)cc3)c2)ccn1)[C@H]1CCOC1 CHEMBL252763 IC50 3.0 nM
CN(c1nccc(-c2cnc3ccccn23)n1)C1CCCCC1 CHEMBL482708 IC50 3.0 nM
CN(C)CCCC(=O)Nc1cc(C(=O)O)cc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL1092764 IC50 3.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 Kd 3.0 nM
Cn1cnc(-c2c(Br)csc2NC(=O)CN2C(=O)CCc3ncccc32)n1 CHEMBL1822305 IC50 3.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2cccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c2)c1C CHEMBL4071770 IC50 3.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2cccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c2)c1 CHEMBL4094220 IC50 3.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)cc1 CHEMBL4082212 IC50 3.0 nM
COCCNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4876387 IC50 3.0 nM
NC(=O)N1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5406554 IC50 3.0 nM
COc1ccc(CCNc2nccc(/C(C#N)=C3\Nc4ccccc4S3)n2)cc1 CHEMBL370516 IC50 3.1 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 3.162 nM
NC(=O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL199136 IC50 3.3 nM
O=C(NCCCN1CCOCC1)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL198687 IC50 3.4 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(-n4ccnn4)cc3)n2)cc1 CHEMBL571626 IC50 4.0 nM
COc1c(-c2cnn(C)c2)ccc2cnc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)nc12 CHEMBL1761584 IC50 4.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c2)cc1 CHEMBL4072555 IC50 4.0 nM
CC(=O)N1CC[C@H](NC(=O)c2cc(-n3ncc4cc(Nc5ccccc5Cl)c(F)cc43)cs2)C1 CHEMBL4862656 IC50 4.0 nM
O=C(NCC(F)F)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4879188 IC50 4.0 nM
O=C(C1CC1)N1CCC[C@H](Nc2nccc(-n3c(-c4ccc5ccccc5c4)nc4ccc(O)cc43)n2)C1 CHEMBL5437462 IC50 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
N#CCc1cnc(-c2ccc3c(c2)CCO3)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5405404 IC50 4.1 nM
CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5438506 IC50 4.33 nM
Nc1ccc(Nc2cc(-c3[nH]cnc3-c3ccc(F)cc3)ccn2)cc1 CHEMBL5271950 IC50 4.7 nM
CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5424892 IC50 4.83 nM
CC(=O)N1CCC[C@@H](C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)C1 CHEMBL202639 IC50 5.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3c(-c4ccccc4)[nH]c4ccccc34)n2)CC1 CHEMBL245936 IC50 5.0 nM
CN(C)c1c(-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)cnn1Cc1ccccc1 CHEMBL1094014 Ki 5.0 nM
O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682014 IC50 5.0 nM
O=C(Cn1c(=O)ccc2cc(F)c(F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822145 IC50 5.0 nM
O=C(NC1COC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)ncc32)cs1 CHEMBL4872832 IC50 5.0 nM
[2H]C([2H])([2H])N1CC[C@H](NC(=O)c2cc(-n3ncc4cc(Nc5ccccc5Cl)c(F)cc43)cs2)C1 CHEMBL4847175 IC50 5.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4874134 IC50 5.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4OC)c(F)cc32)cs1 CHEMBL4875476 IC50 5.0 nM
Cc1nc2c(cnn2-c2csc(C(=O)NC3COC3)c2)cc1Nc1c(F)cccc1Cl CHEMBL4845770 IC50 5.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5394033 IC50 5.0 nM
O=C(O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL197613 IC50 5.3 nM
N#CCc1cnc(-c2ccc(Cl)c(Cl)c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)NC3CC3)C2)n1 CHEMBL5436709 IC50 5.3 nM
CN1CCCC(Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)C1 CHEMBL3355996 IC50 5.5 nM
O=C(Nc1cc(-c2ccnc(Nc3ccc(F)cc3)c2)ccn1)C1CCOCC1 CHEMBL205078 IC50 6.0 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 CHEMBL1682015 IC50 6.0 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1ncn[nH]1 CHEMBL1822139 IC50 6.0 nM
O=C(Cn1c(=O)ccc2cnc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822141 IC50 6.0 nM
O=C(Cn1c(=O)ccc2cc(OC(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822149 IC50 6.0 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncco1 CHEMBL1822153 IC50 6.0 nM
O=C(NC1COC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)cnc32)cs1 CHEMBL4872493 IC50 6.0 nM
N#CCc1cnc(-c2ccc3occc3c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5396572 IC50 6.2 nM
O=C(Nc1cc(-c2ccnc(Nc3ccccc3)c2)ccn1)C1CCOC1 CHEMBL203535 pIC50 6.31 nM
Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL1990496 pKi 6.31 nM
NC(=O)C1Cc2nc(-c3ccc(F)c(C(F)(F)F)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5425334 IC50 6.39 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5405705 IC50 6.82 nM
Fc1ccc(-c2nc3n(c2-c2ccnc(NC4CCC4)n2)[C@H](Cn2ccnc2)CC3)cc1 CHEMBL252762 IC50 7.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(S(N)(=O)=O)cc3)n2)cc1 CHEMBL585916 IC50 7.0 nM
N#Cc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1ncn[nH]1 CHEMBL1682018 IC50 7.0 nM
c1cc(-c2nccs2)c2nc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)ncc2c1 CHEMBL1761566 IC50 7.0 nM
Cc1nc(C)n(-c2ccc(Nc3cc(-c4nn(C)cc4-c4ccc(F)cc4)ccn3)cc2)n1 CHEMBL1771718 IC50 7.0 nM
O=C(Cn1c(=O)ccc2cnccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822140 IC50 7.0 nM
COc1ccc(Oc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 CHEMBL1923217 IC50 7.0 nM
CNC(=O)[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950304 IC50 7.0 nM
Fc1ccc(-c2n[nH]cc2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)cc1 CHEMBL3099962 IC50 7.0 nM
Cc1cc(Nc2nc3ccccc3o2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356003 IC50 7.0 nM
COc1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4cccc(C)c4)cn3)c2)cc(OC)c1OC CHEMBL3393599 IC50 7.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(Nc2cccc(C(=O)C3CC3)c2)n1 CHEMBL5419748 IC50 7.0 nM
N[C@H]1CC[C@@H](Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)CC1 CHEMBL3356000 IC50 7.5 nM
O=C(Nc1cc(-c2ccnc(Nc3ccccc3)c2)ccn1)C1CCOCC1 CHEMBL203059 IC50 8.0 nM
O=C(Cn1c(=O)ccn2nccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822143 IC50 8.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1ncco1 CHEMBL1822307 IC50 8.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1cscn1 CHEMBL1822309 IC50 8.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c(C)c2)cc1 CHEMBL4063964 IC50 8.0 nM
O=C(Nc1cnn(-c2csc(C(=O)N[C@@H]3CCOC3)c2)c1)Nc1ccccc1Cl CHEMBL4753310 IC50 8.0 nM
CC(C)(C)C(=O)N1CCC[C@H](Nc2nccc(-n3c(CC#N)cnc3-c3ccc(Cl)c(Cl)c3)n2)C1 CHEMBL5403895 IC50 8.0 nM
NC(=O)C1Cc2nc(-c3ccc4c(c3)CCO4)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5419594 IC50 8.92 nM
CC(=O)N1CCCC(C(=O)Nc2cc(-c3ccnc(Nc4ccccc4)c3)ccn2)C1 CHEMBL203225 IC50 9.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2-c2cnn(C)c2)cn1 CHEMBL1761582 IC50 9.0 nM
O=C(Cn1c(=O)ccc2cc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822146 IC50 9.0 nM
O=C(Cn1c(=O)ccc2ccc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822147 IC50 9.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1nccs1 CHEMBL1822308 IC50 9.0 nM
COc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5F)ccc43)c2)cc(OC)c1OC CHEMBL1233748 IC50 9.0 nM
NC(=O)C1Cc2nc(-c3ccc4c(c3)CCO4)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5435809 IC50 9.06 nM
CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5436510 IC50 9.36 nM
CC(=O)N1CCC[C@H](C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)C1 CHEMBL202666 IC50 10.0 nM
Cc1c(-c2cnn(C)c2)ccc2cnc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)nc12 CHEMBL1761579 IC50 10.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2-c2ccccc2)cn1 CHEMBL1761583 IC50 10.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 10.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)cc1 CHEMBL4101953 IC50 10.0 nM
O=C(C1CC1)N1CCC[C@H](Nc2nccc(-n3c(-c4ccc5ccccc5c4)nc4c(F)cc(O)cc43)n2)C1 CHEMBL5430912 IC50 10.0 nM
O=C(C1CC1)N1CCC[C@H](Nc2nccc(-n3c(-c4ccc5c(c4)OCCO5)nc4cc(O)c(O)cc43)n2)C1 CHEMBL5408056 IC50 10.0 nM
NC(=O)C1Cc2nc(-c3ccc4c(c3)OCO4)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5401592 IC50 10.0 nM
CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5412347 IC50 10.2 nM
CCOC(=O)C1Cc2nc(-c3ccc4c(c3)CCO4)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5414227 IC50 10.4 nM
CCOC(=O)C1Cc2nc(-c3ccc4c(c3)OCO4)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5413870 IC50 10.5 nM
CCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3n2[C@H](COCc2ccc(OC)cc2)CC3)n1 CHEMBL383348 IC50 10.9 nM
CCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3n2[C@H](Cc2ccc(OC)cc2)CC3)n1 CHEMBL1094013 IC50 10.9 nM
O=C(Cc1cccc2cnccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682017 IC50 11.0 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1nccs1 CHEMBL1822306 IC50 11.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C4CCCC4)c3n2)CC1 CHEMBL3577877 IC50 11.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 11.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 12.0 nM
N#Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1 CHEMBL1682021 IC50 12.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4ccccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946333 IC50 12.0 nM
COc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5Cl)ccc43)c2)cc(OC)c1OC CHEMBL2376910 IC50 12.0 nM
OCCNc1nccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)n1 CHEMBL3355995 IC50 12.0 nM
COc1ccc2c(c1)OCC(C(=O)NC(=O)N(CC(=O)NCCCCCCNC(=O)c1ccc(-c3n[nH]c4ccccc34)cc1)CC(C)C)O2 CHEMBL3393604 IC50 12.0 nM
COC(Cn1c(S/C=C\C(=O)O)nc(-c2ccc(F)cc2)c1-c1ccnc(NC2CC2)c1)OC CHEMBL3394120 IC50 12.0 nM
CC(C)N1CC[C@H](NC(=O)c2cc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)cs2)C1 CHEMBL4784095 IC50 12.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)c(C)nc32)cs1 CHEMBL4859957 IC50 12.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946646 IC50 13.0 nM
O=C1N/C(=N\c2cccc(Cl)c2Cl)S/C1=C1\C(=O)Nc2ccc(F)cc21 CHEMBL5416936 IC50 13.0 nM
CNC(=O)CN1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245336 IC50 14.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2cccc(Cl)c2c1 CHEMBL1644637 IC50 14.0 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822138 IC50 14.0 nM
O=C(Cn1c(=O)ccc2nc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822142 IC50 14.0 nM
O=C(Cn1c(=O)ccn2nc(C(F)(F)F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822144 IC50 14.0 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)c(-c2ccnc(N[C@@H]3CCCNC3)n2)c1 CHEMBL3355997 IC50 14.0 nM
O=C(NC1COC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4847784 IC50 14.0 nM
NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5436937 IC50 14.8 nM
CO[C@H]1CC[C@@H](C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)CC1 CHEMBL202676 IC50 15.0 nM
CC(=O)N1CCCC(C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)C1 CHEMBL206466 IC50 15.0 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1nccs1 CHEMBL1822154 IC50 15.0 nM
COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(Cl)cn2)cc1 CHEMBL1923187 IC50 15.0 nM
O=C(NCCCN1CCOCC1)c1cccc(-n2ncc3cc(Nc4ccccc4Cl)ccc32)c1 CHEMBL2376919 IC50 15.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577868 IC50 15.0 nM
NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5423677 IC50 15.4 nM
O[C@H]1CC[C@H](c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)CC1 CHEMBL507249 IC50 16.0 nM
O[C@H]1CC[C@H](Nc2nccc(-c3c[nH]nc3C3CCCOC3)n2)CC1 CHEMBL1089007 Ki 16.0 nM
O=c1n(C2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644639 IC50 16.0 nM
C[C@H](CS(C)(=O)=O)Nc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1 CHEMBL1232769 Kd 16.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946647 IC50 16.0 nM
Cc1ncn(-c2ccc(Nc3cc(-c4nocc4-c4cn[nH]c4C)ccn3)cc2)n1 CHEMBL3100085 IC50 16.0 nM
NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5420339 IC50 16.4 nM
Fc1ccc(Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)cc1 CHEMBL205672 IC50 17.0 nM
COc1ccc(Oc2cc(Nc3cc(OC)ccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923211 IC50 17.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@H]4CC[C@@H](O)CC4)c3n2)cc1 CHEMBL1946340 IC50 17.0 nM
O=C(O)/C=C\Sc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccccc3)c2)[nH]1 CHEMBL3394125 IC50 17.0 nM
CCC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1C CHEMBL4066691 IC50 17.0 nM
O=C(Nc1cc(-c2ccnc(Nc3ccccc3)c2)ccn1)c1ccco1 CHEMBL380724 IC50 18.0 nM
COc1cc(S(C)(=O)=O)c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1 CHEMBL378627 Ki 18.0 nM
O=C(Cc1cccc2ncccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682020 IC50 18.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2CC2CC2)ccn1 CHEMBL3394106 IC50 18.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC(CCO)CCO)nc21 CHEMBL1090089 Kd 19.0 nM
O=C(Cn1c(=O)ccc2ccc(OC(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822150 IC50 19.0 nM
Cn1cc(-c2conc2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)cn1 CHEMBL3099977 IC50 19.0 nM
COCCC(=O)Nc1cc(-c2ccnc(Nc3ccccc3)c2)ccn1 CHEMBL379254 IC50 20.0 nM
Cn1cc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cn1 CHEMBL1761564 IC50 20.0 nM
Cc1ncn(-c2ccc(Nc3ncc4cccc(-c5nccs5)c4n3)cc2)n1 CHEMBL1761569 IC50 20.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2C2CC2)cn1 CHEMBL1761581 IC50 20.0 nM
Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1 CHEMBL3356002 IC50 20.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(OC)cc32)cs1 CHEMBL4853326 IC50 20.0 nM
CN(C)CCNC(=O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL198821 IC50 21.0 nM
CCN(CC)CCn1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3355175 IC50 21.0 nM
CNC(=O)Oc1cc(F)c2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2c1 CHEMBL5438365 IC50 21.0 nM
CCOC(=O)C1Cc2nc(-c3ccc4c(c3)CCO4)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5401605 IC50 21.5 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 Kd 22.0 nM
O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644638 IC50 22.0 nM
O=C(NCCCN1CCOCC1)c1cccc(-n2ncc3cc(Nc4ccccc4F)ccc32)c1 CHEMBL2376918 IC50 22.0 nM
O=C1c2ccccc2-c2n[nH]c3cccc1c23 CHEMBL7064 Kd 22.0 nM
O=C(Nc1cnn(-c2cccc(C(=O)Nc3cnn(CCN4CCCC4)c3)c2)c1)Nc1ccccc1Cl CHEMBL3355176 IC50 23.0 nM
O=C(Nc1cnn(-c2cccc(C(=O)Nc3cnn(C4CCNCC4)c3)c2)c1)Nc1ccccc1Cl CHEMBL3355177 IC50 23.0 nM
CCC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1 CHEMBL4092482 IC50 23.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 Kd 23.0 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5403970 IC50 23.4 nM
O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644618 IC50 24.0 nM
COC(=O)N1CCC(n2nc(-c3ccnc(NC4CCOCC4)c3)n(-c3ccc4ccccc4c3)c2=O)CC1 CHEMBL1644646 IC50 24.0 nM
O=C(Cc1ccc(F)c2cnccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822132 IC50 24.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@H]4CC[C@@H](C(N)=O)CC4)c3n2)cc1 CHEMBL1946495 IC50 24.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4ccc(F)cc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946837 IC50 24.0 nM
COc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5)ccc43)c2)cc(OC)c1OC CHEMBL2376909 IC50 24.0 nM
Cc1ncn(-c2ccc(Nc3cc(-c4nocc4-c4cn[nH]c4)ccn3)cc2)n1 CHEMBL3099963 IC50 24.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccc(N)cc3)c2)[nH]1 CHEMBL4074524 IC50 24.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NCC3CCOCC3)c2)c1)Nc1ccccc1Cl CHEMBL4744992 IC50 24.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)cnc32)cs1 CHEMBL4851793 IC50 24.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@H]2CCCCN(C(=O)C3CC3)C2)n1 CHEMBL5428554 IC50 24.1 nM
NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5395372 IC50 24.9 nM
Cc1n[nH]c(-c2c(C)csc2NC(=O)CN2C(=O)CCc3ccccc32)n1 CHEMBL1682012 IC50 25.0 nM
Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 CHEMBL1614820 IC50 25.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2CC2CCCCC2)ccn1 CHEMBL3394107 IC50 25.0 nM
COc1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4)cn3)c2)cc(OC)c1OC CHEMBL1233747 IC50 25.0 nM
CCC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c(C)c2)cc1 CHEMBL4093282 IC50 25.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 pKi 25.12 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 25.12 nM
c1ccc(-c2noc(CN3CCCCC3)c2-c2ccnc(NC3CCCCC3)n2)cc1 CHEMBL1080582 IC50 26.0 nM
Fc1ccc(-c2conc2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)cc1 CHEMBL3099965 IC50 26.0 nM
CCC(C)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2CC(OC)OC)ccn1 CHEMBL3394121 IC50 26.0 nM
COC(C)CC(C)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2CC(OC)OC)ccn1 CHEMBL5287474 IC50 26.0 nM
CC(C)(C)Oc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923194 IC50 27.0 nM
CNc1onc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)c1-c1ccc(F)cc1 CHEMBL3099972 IC50 27.0 nM
CCC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)cc1 CHEMBL4085536 IC50 27.0 nM
O=C1N/C(=N\c2cccc(Cl)c2Cl)S/C1=C1\C(=O)Nc2ccc(Cl)cc21 CHEMBL5402716 IC50 27.0 nM
O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682013 IC50 28.0 nM
CC(C)NC(=O)N1CCC(Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577874 IC50 28.0 nM
CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5402048 IC50 28.2 nM
O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644642 IC50 29.0 nM
O=C(Nc1cnn(-c2cccc(C(=O)NC3CCNC3)c2)c1)Nc1ccccc1Cl CHEMBL3355184 IC50 29.0 nM
Clc1ccccc1Nc1ccc2c(-c3ccccc3)[nH]nc2c1 CHEMBL440566 IC50 30.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL259060 IC50 30.0 nM
Cc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cn1 CHEMBL1761563 IC50 30.0 nM
Cc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(C)n5)cc4)nc23)cn1 CHEMBL1761571 IC50 30.0 nM
Cc1ccc(-c2cccc3cnc(N[C@H]4CC[C@@H](C(=O)N5CCCC5)CC4)nc23)cn1 CHEMBL1761576 IC50 30.0 nM
O=C(Cc1cccc2ncc(F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822133 IC50 30.0 nM
COc1ccc(Oc2cc(Nc3ccc(Cl)cc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923208 IC50 30.0 nM
COc1ccc(Oc2nccc(C(C#N)c3nc4ccccc4s3)n2)cc1 CHEMBL3947385 IC50 30.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(N)c4)cc3)c2)n1C CHEMBL4104351 IC50 30.0 nM
CNC(=O)c1cc(-n2ncc3cc(Oc4ccccc4Cl)ccc32)cs1 CHEMBL4864514 IC50 30.0 nM
CNC(=O)C1Cc2nc(-c3ccc(F)c(C(F)(F)F)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5433276 IC50 30.6 nM
CNC(=O)CN1CCC[C@@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL392615 IC50 31.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4ccccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946334 IC50 31.0 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)c(-c2ccnc(N[C@H]3CCCNC3)n2)c1 CHEMBL3355998 IC50 31.0 nM
CC(C)C(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577866 IC50 31.0 nM
CC(C)N1CC[C@@H](NC(=O)c2cc(-n3ncc4cc(Nc5ccccc5Cl)ccc43)cs2)C1 CHEMBL4869300 IC50 31.0 nM
CCOC(=O)C1Cc2nc(-c3ccc4c(c3)CCO4)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5431146 IC50 31.4 nM
O=[N+]([O-])c1cnc(Sc2nnc(O)n2-c2ccc3c(c2)OCCO3)s1 CHEMBL508280 IC50 31.9 nM
O=C(O)c1ccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)cc1 CHEMBL197698 IC50 32.0 nM
Fc1ccccc1Nc1cc(-c2ccnc(Nc3ccccc3F)c2)ccn1 CHEMBL203289 IC50 32.0 nM
COC1CCC(C(=O)Nc2cc(-c3ccnc(Nc4ccccc4)c3)ccn2)CC1 CHEMBL203009 IC50 32.0 nM
CCNC(=O)N1CCC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL392614 IC50 32.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644619 IC50 32.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@@H]4CCOC4)c3n2)CC1 CHEMBL1950303 IC50 32.0 nM
Cc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5Cl)ccc43)c2)ccc1N1CCOCC1 CHEMBL2376913 IC50 32.0 nM
Cc1onc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)c1-c1ccc(F)cc1 CHEMBL3099968 IC50 32.0 nM
CC(C)CCNc1nccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)n1 CHEMBL3355994 IC50 32.0 nM
CN(C)c1ccc(-c2cnc3[nH]cc(-c4cn[nH]c4)c3c2)cc1 CHEMBL3393595 IC50 32.0 nM
Cc1cnc(C(=O)Nc2cc(-c3ccnc(Nc4ccccc4)c3)ccn2)cn1 CHEMBL205402 IC50 33.0 nM
O=C(Cc1cccc2cnccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682016 IC50 33.0 nM
O=C(NCCCN1CCOCC1)c1ccc(-n2ncc3cc(Nc4ccccc4Cl)ccc32)cc1 CHEMBL2376906 IC50 33.0 nM
COC(Cn1c(S/C=C\C(=O)O)nc(-c2ccc(F)cc2)c1-c1ccnc(NC(C)=O)c1)OC CHEMBL3394101 IC50 33.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NC3COC3)c2)c1)Nc1c(F)cccc1Cl CHEMBL4778645 IC50 33.0 nM
CC(C)(C)CNc1ncc(Br)c(Nc2ccccc2C(N)=O)n1 CHEMBL5403766 IC50 33.2 nM
O=C(Cc1cccc2ncccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682019 IC50 34.0 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc(N3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL1923203 IC50 34.0 nM
CN(C)CCn1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3352845 IC50 34.0 nM
O=C(Nc1cnn(-c2cccc(C(=O)NC3CNC3)c2)c1)Nc1ccccc1Cl CHEMBL3355183 IC50 34.0 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc(OC(F)(F)F)cc2)ncc1C(F)(F)F CHEMBL1923191 IC50 35.0 nM
O=C(NCCO)c1cccc(-n2ncc3cc(Nc4ccccc4Cl)ccc32)c1 CHEMBL2376922 IC50 35.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2CC2CCCO2)ccn1 CHEMBL3394108 IC50 35.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NC3COC3)c2)c1)Nc1ccccc1Cl CHEMBL4753641 IC50 35.0 nM
O=c1n(C2CCN(CC(F)(F)F)CC2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644645 IC50 36.0 nM
COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1 CHEMBL1236682 Kd apparent 36.0 nM
NC(=O)C1Cc2nc(-c3ccc4c(c3)OCO4)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5427166 IC50 36.1 nM
COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923188 IC50 37.0 nM
CCNC(=O)N[C@H]1CC[C@@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577871 IC50 37.0 nM
Cc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5F)ccc43)c2)ccc1N1CCOCC1 CHEMBL2376914 IC50 38.0 nM
Cc1ccc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3355146 IC50 38.0 nM
CN1CC[C@H](NC(=O)c2cc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)cs2)C1 CHEMBL4754584 IC50 39.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 pKi 39.81 nM
O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644625 IC50 40.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2Cl)cn1 CHEMBL1761577 IC50 40.0 nM
Cc1cccc(Nc2ccc3c(cnn3-c3cccc(C(=O)NCCN4CCN(C5CCC5)CC4)c3)c2)c1Cl CHEMBL2376926 IC50 40.0 nM
O=C(NCCN1CCN(C2CCC2)CC1)c1cccc(-n2ncc3cc(Nc4ccccc4Cl)ccc32)c1 CHEMBL3393598 IC50 40.0 nM
O=C1N/C(=N/c2ccccc2Cl)S/C1=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4470981 IC50 40.0 nM
N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2ccc(S(N)(=O)=O)cc2)n1 CHEMBL363355 IC50 41.0 nM
O=C(Cc1cc(F)cc2ncccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822134 IC50 41.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 Kd 42.0 nM
COc1ccccc1Nc1ccc2c(cnn2-c2cccc(C(=O)NCCCN3CCOCC3)c2)c1 CHEMBL2376917 IC50 43.0 nM
CC(=O)N1CCC(C(=O)Nc2cc(-c3ccnc(Nc4ccccc4)c3)ccn2)CC1 CHEMBL204757 IC50 44.0 nM
COc1ccc(Oc2cc(Nc3ccc(F)cc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923207 IC50 45.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2C2CCCC2)ccn1 CHEMBL3394104 IC50 45.0 nM
CC1(NC(=O)c2cc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)cs2)COC1 CHEMBL4758113 IC50 45.0 nM
O=C(C1CC1)N1CCC[C@@H](Nc2nccc(-n3c(-c4ccc5ccccc5c4)nc4ccc(O)cc43)n2)C1 CHEMBL2334705 pKd 45.71 nM
CCOc1ccc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5F)ccc43)c2)cc1OC CHEMBL2376911 IC50 46.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2C2CCC2)ccn1 CHEMBL3394103 IC50 47.0 nM
c1ccc(Nc2ccc3c(-c4ccccc4)n[nH]c3c2)cc1 CHEMBL383177 IC50 48.0 nM
CC1CCN(C(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245733 IC50 48.0 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc3c(c2)OCO3)ncc1C(F)(F)F CHEMBL1923201 IC50 48.0 nM
COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(F)cn2)cc1 CHEMBL1923186 IC50 48.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccc(NC(=S)Nc4ccc5c(c4)C(=O)OC54c5ccc(O)cc5Oc5cc(O)ccc54)cc3)c2)[nH]1 CHEMBL5284967 IC50 48.0 nM
COc1ccc(Oc2cc(Nc3cc(F)ccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923209 IC50 49.0 nM
CCOC(=O)C1Cc2nc(-c3ccc4c(c3)OCO4)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5416188 IC50 49.9 nM
c1cc(-n2cnc(N3CCOCC3)n2)ccc1Nc1ncc2ccc(-c3cn[nH]c3)cc2n1 CHEMBL1761555 IC50 50.0 nM
Cc1ccc(-c2ncn(-c3ccc(Nc4ncc5ccc(-c6cn[nH]c6)cc5n4)cc3)n2)cn1 CHEMBL1761561 IC50 50.0 nM
Cc1ccc(-c2cccc3cnc(NC4CCC(O)CC4)nc23)cn1 CHEMBL1761575 IC50 50.0 nM
Fc1ccccc1Nc1nc2cnc(NC3CCCCC3)nc2n1C1CCCC1 CHEMBL1946332 IC50 50.0 nM
CN1CCN(CCNC(=O)c2cccc(-n3ncc4cc(Nc5c(Cl)cccc5Cl)ccc43)c2)CC1 CHEMBL2376925 IC50 50.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NC3CCOCC3)c2)c1)Nc1ccccc1Cl CHEMBL4762965 IC50 50.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NC3CNC3)c2)c1)Nc1ccccc1Cl CHEMBL4783382 IC50 50.0 nM
COc1cc2c(cc1Cl)C(c1ccc(Cl)c(Cl)c1)=NCC2 CHEMBL1087421 pIC50 50.12 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 50.12 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 50.12 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 51.0 nM
O=C(Nc1ccc2[nH]nc(-c3cc4ccccc4s3)c2c1)C1CCOC1 CHEMBL400054 IC50 52.0 nM
O=C(Cc1cccc2ncc(C(F)(F)F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822135 IC50 52.0 nM
Cc1ncn(-c2ccc(Nc3cc(-c4nocc4-c4cnn(C)c4)ccn3)cc2)n1 CHEMBL3100084 IC50 52.0 nM
S=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1784650 IC50 52.2 nM
CCOC(=O)C1Cc2nc(-c3ccc(F)c(C(F)(F)F)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5436272 IC50 52.8 nM
Cc1sc(C(=O)N[C@@H]2CCOC2)cc1-n1cc(NC(=O)Nc2c(F)cccc2Cl)cn1 CHEMBL4749547 IC50 53.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NC3COC3)c2)c1)Nc1ccc(F)cc1Cl CHEMBL4754908 IC50 53.0 nM
CNC(=O)Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2c1 CHEMBL5418625 IC50 53.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2cccc(F)c2c1 CHEMBL1644635 IC50 54.0 nM
O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644615 IC50 54.0 nM
O=C(NCCN1CCOCC1)c1cccc(-n2ncc3cc(Nc4ccccc4Cl)ccc32)c1 CHEMBL2376915 IC50 54.0 nM
O=C(O)/C=C\Sc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccccc3)c2)n1CC1CC1 CHEMBL3394123 IC50 54.0 nM
CCNC(=O)N1CCC(Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577873 IC50 54.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2C)ccn1 CHEMBL3394100 IC50 55.0 nM
N#CCc1cnc(C2=CC3OCOC3C=C2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5439223 IC50 55.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL248176 IC50 57.0 nM
CCNC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577867 IC50 57.0 nM
CC(C)n1c(=O)ccc2cnc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL3577855 IC50 58.0 nM
O=C(CSc1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O)NC1CCCC1 CHEMBL5183304 IC50 58.17 nM
O=C(NCCCN1CCCC1=O)c1cnccc1Nc1nc(-c2cc(Br)ccc2F)nc2nccnc12 CHEMBL234655 IC50 59.0 nM
COc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5C)ccc43)c2)cc(OC)c1OC CHEMBL2376912 IC50 59.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(-c6ccccn6)n5)cc4)nc3c2)cn1 CHEMBL1761562 IC50 60.0 nM
c1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cc1 CHEMBL1761567 IC50 60.0 nM
Cc1ccc(-c2cccc3cnc(Nc4ccc5c(c4)OCO5)nc23)cn1 CHEMBL1761572 IC50 60.0 nM
Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCC2(CC1)OCCO2 CHEMBL1783587 IC50 60.0 nM
COc1ccc(Oc2cc(Nc3c(F)cccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923212 IC50 60.0 nM
N#CC(c1ccnc(OCc2ccccc2)n1)c1nc2ccccc2s1 CHEMBL3899711 IC50 60.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1Cl CHEMBL210928 Ki 61.0 nM
O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644624 IC50 61.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2)ncc1C(F)(F)F CHEMBL3220469 IC50 61.0 nM
CCNC(=O)N1CCC(Nc2cc(-c3c(-c4ccc(F)cc4)nc(S/C=C\C(=O)O)n3C)ccn2)CC1 CHEMBL3394122 IC50 61.0 nM
COc1ccc(COC[C@@H]2CCc3nc(-c4ccc(F)cc4)c(-c4ccnc(N)n4)n32)cc1 CHEMBL372082 IC50 61.2 nM
COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cnccc12 CHEMBL1681791 IC50 62.0 nM
Cc1ncc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3355167 IC50 62.0 nM
CC(C)n1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2Cl)cn1 CHEMBL1761578 IC50 63.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C4CCOCC4)c3n2)cc1 CHEMBL1946341 IC50 63.0 nM
NC(=O)c1cccc(-n2ncc3cc(Nc4ccccc4F)ccc32)c1 CHEMBL2376924 IC50 63.0 nM
NC(=O)C1Cc2nc(-c3ccc4c(c3)CCO4)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5418507 IC50 63.0 nM
O=C1N/C(=N\c2ccccc2Cl)S/C1=C1\C(=O)Nc2ccc(I)cc21 CHEMBL5420689 IC50 63.0 nM
CCOC(=O)C1Cc2nc(-c3ccc(F)c(C(F)(F)F)c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5426262 IC50 63.1 nM
COc1ccc(C(=O)O/N=C2/c3ccccc3-c3nc4ccccc4nc32)cc1OC CHEMBL3393603 Kd 64.0 nM
CCOC(=O)C1Cc2nc(-c3ccc(F)c(C(F)(F)F)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5399618 IC50 65.4 nM
O=C(O/N=C1/c2ccccc2-c2nc3ccccc3nc21)c1ccco1 CHEMBL3393602 Kd 66.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 67.0 nM
Cc1sc(C(=O)NC2COC2)cc1-n1cc(NC(=O)Nc2c(F)cccc2Cl)cn1 CHEMBL4784092 IC50 67.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Br CHEMBL3220467 IC50 68.0 nM
O=C(N[C@@H](c1ccccn1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422092 IC50 68.0 nM
N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1 CHEMBL1788116 IC50 70.0 nM
N#CC(c1ccnc(NCCc2c[nH]cn2)n1)c1nc2ccccc2s1 CHEMBL254651 IC50 70.0 nM
N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1 CHEMBL191384 IC50 70.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644622 IC50 70.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2cc(F)ccc2c1 CHEMBL1644632 IC50 70.0 nM
COc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cc1F CHEMBL1761565 IC50 70.0 nM
Clc1cnc(Nc2ccc(N3CCOCC3)cc2)cc1-c1cc[nH]n1 CHEMBL1771661 IC50 70.0 nM
COc1cccc(Oc2cc(Nc3ccccc3C(N)=O)c(C(F)(F)F)cn2)c1 CHEMBL1923189 IC50 70.0 nM
NC(=O)c1ccccc1Nc1ccnc(Oc2ccc(N3CCNCC3)cc2)c1 CHEMBL1923185 IC50 70.0 nM
Fc1ccc(-c2c(-c3ccnc(Nc4ccc(N5CCOCC5)cc4)c3)noc2C2CC2)cc1 CHEMBL3099967 IC50 70.0 nM
N#CC(c1ccnc(NC2Cc3c[nH]c2n3)n1)c1nc2ccccc2s1 CHEMBL3909478 IC50 70.0 nM
N#CC(c1ccnc(NCCc2cccnc2)n1)c1nc2ccccc2s1 CHEMBL406703 IC50 70.0 nM
O=C(Cn1c(=O)ccc2c(C(F)(F)F)cccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822148 IC50 71.0 nM
Cc1ccc(NC(=O)c2cc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)ccc2F)cn1 CHEMBL3355158 IC50 71.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NC[C@H]3CCOC3)c2)c1)Nc1ccccc1Cl CHEMBL4755895 IC50 71.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1C#N CHEMBL210963 Ki 72.0 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc(-c3cccnc3)cc2)ncc1C(F)(F)F CHEMBL1923204 IC50 72.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 Kd apparent 72.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 73.1 nM
c1cc(-c2nocc2C2CC2)cc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL3100083 IC50 74.0 nM
O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(=S)Nc3ccc(Nc4cc(-c5[nH]cnc5-c5ccc(F)cc5)ccn4)cc3)cc21 CHEMBL5274433 IC50 74.0 nM
CCOC(=O)CO/N=C1\c2ccccc2-c2nc3ccccc3nc21 CHEMBL4582239 Kd 76.0 nM
O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1 CHEMBL1288160 IC50 77.0 nM
O=C(NCCN1CCOCC1)c1cccc(-n2ncc3cc(Nc4c(Cl)cccc4Cl)ccc32)c1 CHEMBL2376916 IC50 77.0 nM
COc1ccc(Oc2cc(Nc3cc(Cl)ccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923210 IC50 78.0 nM
O=C1N/C(=N\c2ccccc2F)S/C1=C1\C(=O)Nc2ccc(Cl)cc21 CHEMBL5410150 IC50 78.0 nM
CC(=O)Nc1ccc2c(c1)/C(=C1/S/C(=N/c3cccc(Cl)c3Cl)NC1=O)C(=O)N2 CHEMBL5406652 IC50 78.0 nM
CN1CCC(C(=O)Nc2ccc3c(c2)/C(=C2/S/C(=N/c4cccc(Cl)c4Cl)NC2=O)C(=O)N3)CC1 CHEMBL5432203 IC50 78.0 nM
Cc1ncn(-c2ccc(Nc3nccc(-c4cc(C#N)cc(N5CCOCC5)c4)n3)cc2)n1 CHEMBL570554 IC50 79.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(-n4cnc(-c5ccccn5)n4)cc3)n2)cc(N2CCOCC2)c1 CHEMBL584899 IC50 79.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(SC3CCC(C(=O)O)CC3O)n2C2CCCCC2)ccn1 CHEMBL3394110 IC50 79.0 nM
COC(Cn1c(SCC#N)nc(-c2ccc(F)cc2)c1-c1ccnc(NC2CC2)c1)OC CHEMBL3394119 IC50 79.0 nM
Cc1nc2c(cnn2-c2csc(C(=O)NC3COC3)c2)cc1Nc1ccc(F)cc1Cl CHEMBL4854405 IC50 79.0 nM
Cc1n[nH]c(-c2c(C)csc2NC(=O)Cc2cccc3ncccc23)n1 CHEMBL1682010 IC50 80.0 nM
COc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(C)n5)cc4)nc23)cc1F CHEMBL1761568 IC50 80.0 nM
Cc1cccc(NC(=O)c2ccc(Cl)o2)c1N1CCC2(CC1)OCCO2 CHEMBL1783588 IC50 80.0 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc(-n3cncn3)cc2)ncc1C(F)(F)F CHEMBL1923202 IC50 80.0 nM
O=C(NCCN1CCOCC1)c1cccc(-n2ncc3cc(Nc4ccccc4Cl)ncc32)c1 CHEMBL2376931 IC50 80.0 nM
Cc1ccc(NC(=O)c2ccc(F)c(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3355156 IC50 80.0 nM
CCOC(=O)/C=C\Sc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccccc3)c2)[nH]1 CHEMBL3394126 IC50 80.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NC3CC3)c2)c1)Nc1ccccc1Cl CHEMBL4793809 IC50 80.0 nM
CC(C)n1c(=O)ccc2cnc(N[C@H]3CC[C@H](NC(=O)NC4CCCC4)CC3)nc21 CHEMBL3577869 IC50 81.0 nM
CCOC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245533 IC50 82.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(S/C=C\C(=O)O)n2C2CC2)ccn1 CHEMBL3394102 IC50 82.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL3220466 IC50 83.0 nM
[2H]C([2H])([2H])N1CC[C@@H](NC(=O)c2cc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)cs2)C1 CHEMBL4799926 IC50 83.0 nM
CN1CCC(NC(=O)c2cc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)cs2)CC1 CHEMBL4759538 IC50 84.0 nM
C[C@H]1CN(C(=O)c2ccc(NC(=O)/C=C/CN(C)C)cc2)C[C@H]1Nc1nccc(-c2c(-c3ccccc3)nn3ccccc23)n1 CHEMBL5398852 IC50 84.0 nM
O=C1N/C(=N\c2cccc(Cl)c2F)S/C1=C1\C(=O)Nc2ccc(F)cc21 CHEMBL5426713 IC50 84.0 nM
c1cncc(-c2ncn(-c3ccc(Nc4nccc(-c5cccc(N6CCOCC6)c5)n4)cc3)n2)c1 CHEMBL571023 IC50 85.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644620 IC50 85.0 nM
Cn1cc(-c2c[nH]c3ncc([C@H]4CC[C@H](N5CCOCC5)CC4)cc23)cn1 CHEMBL3393596 IC50 85.0 nM
CN1CCC[C@H]1CNC(=O)c1cc(-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cs1 CHEMBL4798047 IC50 85.0 nM
CN1CC[C@@H](NC(=O)c2cc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)cs2)C1 CHEMBL4745961 IC50 85.0 nM
O=C(c1cccc(CNc2n[nH]c3cccc(Cl)c23)c1)N1CCN(C(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL5393904 IC50 85.21 nM
O=C1c2ccccc2C2=NNC3=CC=CC1C32 CHEMBL252761 IC50 86.78 nM
NC(=O)C1Cc2nc(-c3ccc4c(c3)CCO4)n(-c3ccnc(N[C@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5424108 IC50 87.3 nM
O=C1N/C(=N\c2cccc(Cl)c2Cl)S/C1=C1\C(=O)Nc2ccc([N+](=O)[O-])cc21 CHEMBL5395599 IC50 89.0 nM
Cc1ccc2c(c1)N(Cc1cc(F)cc3c1OCOC3)C(=O)/C2=N\O CHEMBL551140 Ki 90.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2)cn1 CHEMBL1761554 IC50 90.0 nM
COc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(-c6ccccn6)n5)cc4)nc23)cc1F CHEMBL1761570 IC50 90.0 nM
Cc1ccc(-c2cccc3cnc(Nc4ccc(C(=O)N5CCOCC5)cc4)nc23)cn1 CHEMBL1761574 IC50 90.0 nM
c1ccc2c(c1)Cc1cccc3[nH]nc-2c13 CHEMBL4462592 IC50 90.0 nM
O=C1C2=CC=CC3NN=C(c4ccccc41)C23 CHEMBL5439929 IC50 90.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc(SCCC(=O)O)n2C)ccn1 CHEMBL3394098 IC50 91.0 nM
O=c1n(C2CCOC2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644640 IC50 92.0 nM
COc1ccccc1/N=C1\NC(=O)/C(=C2/C(=O)Nc3ccc(F)cc32)S1 CHEMBL5423835 IC50 92.0 nM
CNC(=O)C1Cc2nc(-c3ccc4c(c3)OCO4)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5423313 IC50 93.9 nM
Nc1cccc2ccc(-n3c(-c4ccnc(NC5CCOCC5)c4)n[nH]c3=O)cc12 CHEMBL1644636 IC50 94.0 nM
FC1(F)CCC(Nc2nccc(-c3cn[nH]c3C3(C(F)(F)F)CC3)n2)CC1 CHEMBL5281537 IC50 94.0 nM
O=C1N/C(=N\c2cccc(F)c2F)S/C1=C1\C(=O)Nc2ccc(F)cc21 CHEMBL5410221 IC50 95.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C(C)C)c3n2)cc1 CHEMBL1946336 IC50 96.0 nM
O=C1N/C(=N\c2ccccc2Cl)S/C1=C1\C(=O)Nc2ccc([N+](=O)[O-])cc21 CHEMBL5407582 IC50 96.0 nM
O=C(NCCCNc1cc(-c2cn(-c3ccccc3)nc2-c2cccc(O)c2)ccn1)Nc1ccc(F)cc1 CHEMBL5191468 IC50 97.4 nM
Cc1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)ccn1 CHEMBL3355165 IC50 98.0 nM
COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCCC2)cc1 CHEMBL1682000 IC50 99.0 nM
O=C(NCCNc1cc(-c2cn(-c3ccccc3)nc2-c2cccc(O)c2)ccn1)Nc1cccc(C(F)(F)F)c1 CHEMBL5201911 IC50 99.0 nM
CC(C)CN(CC(=O)NCCCCCCNC(=O)c1ccc(-c2n[nH]c3ccccc23)cc1)C(=O)CNC(=O)C1COc2ccccc2C1 CHEMBL5193515 IC50 99.0 nM