Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3(C)CC3)nnc2c1 CHEMBL2087507 IC50 0.64 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccncc3Cl)nnc2c1 CHEMBL2087515 IC50 0.83 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccccc3Cl)nnc2c1 CHEMBL2087513 IC50 1.6 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)N(C)C)nnc2c1 CHEMBL2087524 IC50 1.7 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCC3)nnc2c1 CHEMBL2087509 IC50 1.9 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)C)nnc2c1 CHEMBL2087501 IC50 2.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)C)nnc2c1 CHEMBL2087503 IC50 3.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)O)nnc2c1 CHEMBL2087526 IC50 3.1 nM
Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3)c21 CHEMBL561932 IC50 4.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)C)nnc2c1F CHEMBL2087742 IC50 6.2 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccccc3Cl)nnc2c1 CHEMBL2087512 IC50 6.3 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CC3)nnc2c1 CHEMBL2087505 IC50 6.7 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)C)nnc2c1F CHEMBL2087743 IC50 6.7 nM
COC(C)(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccn12 CHEMBL2087522 IC50 9.4 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C3CC3)nnc2c1F CHEMBL2087744 IC50 10.0 nM
Cc1ccccc1-n1nc(-c2c(-c3ccc(F)cc3)nn3c2NC[C@@H](CO)C3)ccc1=O CHEMBL2170294 IC50 11.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3(C)CC3)nnc2c1 CHEMBL2087506 IC50 12.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)N)nnc2c1F CHEMBL2087746 IC50 12.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 13.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N3CCCCC3)noc2c1 CHEMBL2087499 IC50 14.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)N(C)C)nnc2c1F CHEMBL2087747 IC50 15.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)N)nnc2c1 CHEMBL2087521 IC50 15.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)C)nnc2c1 CHEMBL2087500 IC50 16.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)(C)NS(C)(=O)=O)nnc2c1 CHEMBL2087525 IC50 17.0 nM
COC(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccn12 CHEMBL2087517 IC50 18.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCC3)nnc2c1 CHEMBL2087508 IC50 20.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1c(F)cn2c(-c3ccncc3Cl)nnc2c1F CHEMBL2087745 IC50 23.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3CC3)nnc2c1 CHEMBL2087504 IC50 26.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C(C)C)nnc2c1 CHEMBL2087502 IC50 27.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ncc(CCN3CCOCC3)s2)cc1 CHEMBL3895054 IC50 27.54 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCOCC3)nnc2c1 CHEMBL2087511 IC50 30.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 31.62 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(-c3ccncc3Cl)nnc2c1 CHEMBL2087514 IC50 38.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 39.0 nM
COC(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)ccc3C)ccn12 CHEMBL2087516 IC50 43.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1c(F)cn2c(C(C)(C)C)nnc2c1F CHEMBL2087741 IC50 49.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 pKi 50.12 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 54.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C3CCOCC3)nnc2c1 CHEMBL2087510 IC50 56.0 nM
CC(C)(C)c1nnc2ccc(Sc3ccc(F)cc3F)cn12 CHEMBL1198626 IC50 62.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 63.1 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 63.1 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 63.1 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 79.43 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 79.43 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 79.43 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 81.0 nM
Cn1nc(C(C)(C)C)cc1NC(=O)Nc1ccc(Oc2ccncc2)cc1 CHEMBL472620 IC50 82.72 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(F)(F)F)nnc2c1 CHEMBL2087519 IC50 85.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 100.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccn2c(C(N)=O)nnc2c1 CHEMBL2087520 IC50 102.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 125.89 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 125.89 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 125.89 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 125.89 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 158.49 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 158.49 nM
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 CHEMBL4552628 IC50 160.0 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 199.53 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 199.53 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 199.53 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 214.0 nM
COc1cccc(NC(=O)c2cnn3c(-c4ccccc4)ccnc23)c1 CHEMBL1997759 pKi 251.19 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 251.19 nM
CC(=O)NC(C)(C)c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccn12 CHEMBL2087523 IC50 253.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccncc3)cc2)cc1 CHEMBL3948841 IC50 280.5 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 316.23 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 347.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 398.11 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 398.11 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 CHEMBL2380845 IC50 411.0 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(Cl)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1987054 pKi 501.19 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 501.19 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 501.19 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 501.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 630.96 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 630.96 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 630.96 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 630.96 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 690.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 794.33 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 794.33 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 794.33 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 794.33 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 794.33 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(C(F)(F)F)nnc2c1 CHEMBL2087518 IC50 853.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCC(CO)CC5)n4c3)c3ccccc32)cc1 CHEMBL5197888 IC50 931.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 1000.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 1000.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM