CC(C)(C)c1cc(NC(=O)NCc2ccccc2Sc2ccc3nnc(-c4ccccc4SCCO)n3c2)n(-c2ccc(O)c(Cl)c2)n1 CHEMBL1938400 Kd 0.001 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cncc(OCCN(C)C)c4)c4ccccc43)cn12 CHEMBL5186216 IC50 0.03 nM
Cc1ccc(C(=O)Nc2ccon2)cc1-c1ccc2c(c1)NC(=O)C2(C)C CHEMBL3640006 IC50 0.04 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 0.046 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(-c3ccccc3F)nncc2c1 CHEMBL1088796 Kd 0.05 nM
CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(Cl)c(O)c4)c4ccccc43)cn12 CHEMBL5172781 IC50 0.05 nM
C[C@@H]1CCC[C@H](C)N1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnn(CCN(C)C)c4)c4ccccc43)cn12 CHEMBL5174953 IC50 0.05 nM
Cc1ccc2c(NC3CC3)noc2c1-c1ccc2c(c1)NC(=O)C21CCC(F)(F)CC1 CHEMBL1911339 IC50 0.06 nM
Cc1ccc(C(=O)Nc2ccon2)cc1-c1ccc2c(c1)NC(=O)C21CCOCC1 CHEMBL1825148 IC50 0.06 nM
CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccccc4)c4ccccc43)cn12 CHEMBL5180443 IC50 0.06 nM
CC(C)(C)N1CCC(c2cc(-c3ccc(F)cc3F)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199679 IC50 0.08 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCSCC1 CHEMBL1825149 IC50 0.08 nM
CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(O)c(Cl)c4)c4ccccc43)cn12 CHEMBL5206397 IC50 0.08 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)n(-c2ccccc2)n1 CHEMBL318810 Kd 0.09 nM
O=C1NCc2c(-c3ccc(F)cc3Cl)cc(C3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL328614 IC50 0.1 nM
O=C1NCc2c(-c3ccccc3Cl)cc(CN3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL97227 IC50 0.1 nM
O=C1NCc2c(-c3ccc(F)cc3Cl)cc(OC3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL327959 IC50 0.1 nM
CC(C)(C)N1CCC(c2cc(-c3ccccc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199680 IC50 0.1 nM
C[C@H](Nc1cc(-c2c(-c3cccc(C(F)(F)F)c3)nc(C3CCNCC3)n2C)ccn1)c1ccccc1 CHEMBL303144 IC50 0.1 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccc(F)c4)c(F)cc3F)cc1CC2 CHEMBL4060815 IC50 0.1 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@H](Oc3ccc4nnc(C(C)C)n4c3)c3ccccc32)cc1 CHEMBL5173417 IC50 0.1 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(C5CCCC5)n4c3)c3ccccc32)cc1 CHEMBL5200224 IC50 0.1 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnn(CCN(C)C)c4)c4ccccc43)cn12 CHEMBL5202475 IC50 0.1 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCc3ccncc3)c3ccccc23)cc1 CHEMBL143134 Kd 0.104 nM
CC(C)(N)C(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 CHEMBL270004 IC50 0.12 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1991678 pKi 0.1259 nM
O=C1NCc2c(-c3ccc(F)cc3Cl)cc(CN3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL327746 IC50 0.13 nM
[O-][n+]1ccc2c(-c3ccccc3Cl)cc(NC3CCNCC3)nc2c1-c1c(Cl)cccc1Cl CHEMBL1916528 IC50 0.13 nM
C[C@H](N)C(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 CHEMBL269792 IC50 0.16 nM
Cc1ccc2c(NC3CC3)noc2c1-c1ccc2c(c1)NC(=O)C21CCOCC1 CHEMBL1911338 IC50 0.16 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3ccccc3F)c2n(C)c1=O CHEMBL1092013 Kd 0.18 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CN2CCNCC2)c1=O CHEMBL4764056 pIC50 0.1995 nM
O=C1NCc2c(-c3ccc(F)cc3F)cc(C3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL319556 IC50 0.2 nM
O=C1NCc2c(-c3ccccc3Cl)cc(OC3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL94825 IC50 0.2 nM
CC(C)(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3c(c2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL316604 IC50 0.2 nM
CC(C)N1CCC(c2cc(-c3ccc(F)cc3F)c3c(c2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL212549 IC50 0.2 nM
C[C@@H](N)C(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 CHEMBL255403 IC50 0.2 nM
Cc1ccc(C(=O)Nc2ccon2)cc1Nc1ncnc2c1cnn2-c1ccccc1 CHEMBL259922 Ki 0.2 nM
CC[C@H](C)Nc1nncc2cc(-c3c(C)ccc4c(NC)noc34)ccc12 CHEMBL522689 Ki 0.2 nM
CNc1noc2c(-c3ccc4c(N5CCOC[C@@H]5C)nncc4c3)c(Cl)ccc12 CHEMBL495118 Ki 0.2 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 Kd 0.2 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1CC2 CHEMBL2316207 IC50 0.2 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)s1 CHEMBL2401994 IC50 0.2 nM
Cc1ccccc1-c1nncc2nc(Oc3ccc(F)cc3F)ccc12 CHEMBL3649495 IC50 0.2 nM
Cc1ccc(C(=O)Nc2ccon2)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1800222 IC50 0.2 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccc(C(F)(F)F)cc4)c(F)cc3F)cc1CC2 CHEMBL4104440 IC50 0.2 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccc(OC)c4)c(F)cc3F)cc1CC2 CHEMBL4069496 IC50 0.2 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccc(Cl)cc4)c(F)cc3F)cc1CC2 CHEMBL4073561 IC50 0.2 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)cc1CC2 CHEMBL4066023 IC50 0.2 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(C(C)C)n4c3)c3ccccc32)cc1 CHEMBL5206328 IC50 0.2 nM
CN(C)CCOc1cc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)ccc1Cl CHEMBL5207849 IC50 0.2 nM
C[C@@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN(C)C)c4)c4ccccc43)cn12 CHEMBL5203796 IC50 0.2 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN(C)C)c4)c4ccccc43)cn12 CHEMBL5208103 IC50 0.2 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccn(CCN(C)C)n4)c4ccccc43)cn12 CHEMBL5198434 IC50 0.2 nM
CCN(C)CCn1cc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCC[C@@H]5C)n4c3)c3ccccc32)cn1 CHEMBL5198371 IC50 0.2 nM
COCCN(C)CCn1cc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCC[C@@H]5C)n4c3)c3ccccc32)cn1 CHEMBL5190010 IC50 0.2 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O CHEMBL1089865 Kd 0.25 nM
Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL1990496 pKi 0.2512 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CN2CCN[C@H](C)C2)c1=O CHEMBL4764499 pIC50 0.2512 nM
CNCCOc1ccccc1C(C)(C)Nc1nccn(-c2cc(C(=O)NC3CC3)ccc2C)c1=O CHEMBL4792347 pIC50 0.2512 nM
CC1(C)C=C(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC(C)(C)N1 CHEMBL369989 IC50 0.26 nM
[O-][n+]1ccc2c(-c3ccccc3Cl)cc(N3CCNCC3)nc2c1-c1c(Cl)cccc1Cl CHEMBL1916527 IC50 0.26 nM
CC(C)(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL381632 IC50 0.27 nM
[O-][n+]1ccc2c(-c3ccccc3Cl)cc(C3CCNCC3)nc2c1-c1c(F)cccc1F CHEMBL1916523 IC50 0.27 nM
[O-][n+]1ccc2c(-c3ccc(F)cc3F)cc(NC3CCNCC3)nc2c1-c1c(F)cccc1F CHEMBL1916525 IC50 0.28 nM
Cc1cc(F)c(NC(=O)c2ccccc2)cc1Nc1ccc2c(c1)CCc1ccc(C(=O)NC[C@@H](O)CO)cc1C2=O CHEMBL4074237 IC50 0.28 nM
CC(C1CC1)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3c(c2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL318934 pIC50 0.2999 nM
CC(C)(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(F)cccc4F)c3c2)CC1 CHEMBL199484 IC50 0.3 nM
NCC(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 CHEMBL437024 IC50 0.3 nM
CNc1noc2c(-c3ccc4c(N5CCOC[C@H]5C)nncc4c3)c(C)ccc12 CHEMBL493496 Ki 0.3 nM
Cc1ccc2c(N)noc2c1-c1ccc2c(N3CCOC[C@@H]3C)nncc2c1 CHEMBL494916 Ki 0.3 nM
CCNc1noc2c(-c3ccc4c(N5CCOC[C@@H]5C)nncc4c3)c(C)ccc12 CHEMBL495493 Ki 0.3 nM
Cn1c(=O)c(-c2ccccc2Cl)cc2cnc(NC3CCOCC3)nc21 CHEMBL1766490 Kd 0.3 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OCCN4CCOCC4)cc2C3=O)ccc1F)c1ccsc1 CHEMBL2316490 IC50 0.3 nM
Fc1ccc(Nc2ccc3c(-c4ccc(F)cc4F)nncc3n2)c(F)c1 CHEMBL3649487 IC50 0.3 nM
Cc1ccc(C(N)=O)cc1-c1nncc2nc(Oc3ccc(F)cc3F)ccc12 CHEMBL3649496 IC50 0.3 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccc(Cl)c4)c(F)cc3F)cc1CC2 CHEMBL4100394 IC50 0.3 nM
O=C(NCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1CC2 CHEMBL4066347 IC50 0.3 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1CC2 CHEMBL4101643 IC50 0.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3ccc(F)cc3F)c2n(C)c1=O CHEMBL1091199 Kd 0.3 nM
CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4C)c4ccccc43)cn12 CHEMBL5198204 IC50 0.3 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(C5CCCCC5)n4c3)c3ccccc32)cc1 CHEMBL5176351 IC50 0.3 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)cc1 CHEMBL5184542 IC50 0.3 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCC(CO)CC5)n4c3)c3ccccc32)cc1 CHEMBL5197888 IC50 0.3 nM
C[C@H]1CCCCC1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(CN5CCN(C)CC5)c4)c4ccccc43)cn12 CHEMBL5198646 IC50 0.3 nM
C[C@@H]1CCC[C@H](C)N1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN(C)C)c4)c4ccccc43)cn12 CHEMBL5194894 IC50 0.3 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN5CCN(C)CC5)c4)c4ccccc43)cn12 CHEMBL5190292 IC50 0.3 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnnc(OCCN(C)C)c4)c4ccccc43)cn12 CHEMBL5189475 IC50 0.3 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnn(CCN5CCN(C)CC5)c4)c4ccccc43)cn12 CHEMBL5186620 IC50 0.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(NC(C)(C)c2ccccc2OCCN2CCCC2)c1=O CHEMBL4760873 pIC50 0.3162 nM
CC(C)(C)N1CCC(c2cc3c(ccc(=O)n3-c3c(Cl)cccc3Cl)c(-c3ccc(F)cc3Cl)n2)CC1 CHEMBL199291 IC50 0.38 nM
O=C1NCc2c(-c3ccc(F)cc3Cl)cc(C3CCN(C4CCC4)CC3)cc2N1c1c(Cl)cccc1Cl CHEMBL419140 pIC50 0.3999 nM
COc1ccccc1-c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL378919 IC50 0.4 nM
CCOc1ccccc1-c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL209644 IC50 0.4 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NCc4ccccc4)c(C)c23)c1 CHEMBL437971 IC50 0.4 nM
Cc1ccccc1-c1nncc2cc(-c3c(C)ccc4c(NC5CC5)noc34)ccc12 CHEMBL495084 Ki 0.4 nM
CNc1noc2c(-c3ccc4c(OC(C)C)nncc4c3)c(C)ccc12 CHEMBL494917 Ki 0.4 nM
CC(C)Nc1noc2c(-c3ccc4c(N5CCOC[C@@H]5C)nncc4c3)c(Cl)ccc12 CHEMBL523516 Ki 0.4 nM
CNc1noc2c(-c3ccc4c(N5CCOC[C@@H]5C)nncc4c3)c(C)ccc12 CHEMBL523374 Ki 0.4 nM
Cc1ccc2c(NC3CC3)noc2c1-c1ccc2c(c1)NC(=O)C2(C)C CHEMBL1911337 IC50 0.4 nM
CC(C)c1nnc2ccc(Sc3ccccc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3ccccc3)cn12 CHEMBL1938736 Kd 0.4 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccc(OC)cc4)c(F)cc3F)cc1CC2 CHEMBL4096722 IC50 0.4 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccc(F)cc4)c(F)cc3F)cc1CC2 CHEMBL4089021 IC50 0.4 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)cc1CC2 CHEMBL4087408 IC50 0.4 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccsc4)c(F)cc3C)cc1OC2 CHEMBL4072910 IC50 0.4 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1CC2 CHEMBL4082939 IC50 0.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(-c3ccccc3C)nncc2c1 CHEMBL492265 Ki 0.4 nM
CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCC(O)CC5)n4c3)c3ccccc32)n(-c2ccc(CO)cc2)n1 CHEMBL5202281 IC50 0.4 nM
CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCO)c4)c4ccccc43)cn12 CHEMBL5193720 IC50 0.4 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnn(CCN5CCCOCC5)c4)c4ccccc43)cn12 CHEMBL5177395 IC50 0.4 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnn(CCN5CCC(O)CC5)c4)c4ccccc43)cn12 CHEMBL5195994 IC50 0.4 nM
CCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4cc(F)cc(N5CCOCC5)c4)ccc3C)c2c1C CHEMBL262592 Ki 0.42 nM
Cc1ccc(NC(=O)c2ccnc(N3CCOCC3)c2)cc1Nc1ncnn2cc(C(=O)N[C@@H](C)c3ccccc3)c(C)c12 CHEMBL258895 Ki 0.44 nM
O=c1ccc2c(-c3ccc(F)cc3Cl)cc(C3CC4CCC(C3)N4)cc2n1-c1c(Cl)cccc1Cl CHEMBL199701 IC50 0.45 nM
Cc1ccc(NC(=O)c2cccc(N3CCOCC3)c2)cc1Nc1ncnn2cc(C(=O)N[C@@H](C)c3ccccc3)c(C)c12 CHEMBL408150 Ki 0.46 nM
[O-][n+]1ccc2c(-c3ccccc3Cl)cc(OC3CCNCC3)nc2c1-c1c(Cl)cccc1Cl CHEMBL1916530 IC50 0.46 nM
Cc1cc(C)cc(Nc2nccc(-c3c(-c4ccc(F)cc4)ncn3C3CCNCC3)n2)c1 CHEMBL4521096 Kd 0.47 nM
Cc1cc(C)cc(Oc2nccc(-c3c(-c4ccc(F)cc4)ncn3C3CCNCC3)n2)c1 CHEMBL417255 Kd 0.47 nM
C[C@@H]1CN(Cc2ccc(F)cc2)[C@@H](C)CN1C(=O)c1cc2c(C(=O)C(=O)N(C)C)cn(C)c2cc1Cl CHEMBL514201 Kd 0.48 nM
[O-][n+]1ccc2c(-c3ccc(F)cc3Cl)cc(C3CCNCC3)nc2c1-c1c(Cl)cccc1Cl CHEMBL1916360 IC50 0.49 nM
O=C1NCc2c(-c3ccccc3Cl)cc(NC3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL327987 IC50 0.5 nM
CN1CCC(c2cc(-c3ccc(F)cc3Cl)c3c(c2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL96653 IC50 0.5 nM
O=C1NCc2c(-c3ccc(F)cc3Cl)cc(C3CCN(CC4CC4)CC3)cc2N1c1c(Cl)cccc1Cl CHEMBL419134 IC50 0.5 nM
CN(C)CCN1CCN(c2nc(-c3ccccc3Cl)c3c(n2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL211795 IC50 0.5 nM
CN1C2CCC1CC(Nc1nc(-c3ccccc3Cl)c3c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC3)C2 CHEMBL212803 IC50 0.5 nM
NC(CO)C(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 CHEMBL257697 IC50 0.5 nM
CNc1noc2c(-c3ccc4c(NC(C)C)nncc4c3)c(C)ccc12 CHEMBL494305 Ki 0.5 nM
Cc1ccc2c(NC3CC3)noc2c1-c1ccc2c(NC(C)C)nncc2c1 CHEMBL495492 Ki 0.5 nM
CN1C(C)(C)CC(Nc2cc(-c3ccccc3Cl)c3cc[n+]([O-])c(-c4c(Cl)cccc4Cl)c3n2)CC1(C)C CHEMBL1916529 IC50 0.5 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OCCN4CCOCC4)cc2C3=O)c(F)cc1F)c1ccsc1 CHEMBL2316466 IC50 0.5 nM
Cc1ccccc1-c1nncc2nc(Nc3ccc(F)cc3F)ccc12 CHEMBL3649483 IC50 0.5 nM
Cc1cc(S(C)(=O)=O)ccc1-c1nncc2nc(Nc3ccc(F)cc3F)ccc12 CHEMBL3649484 IC50 0.5 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1CC2 CHEMBL4077602 IC50 0.5 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCC5)n4c3)c3ccccc32)cc1 CHEMBL5201578 IC50 0.5 nM
CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2ccc(Cl)c(O)c2)n1 CHEMBL5203029 IC50 0.5 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCC(O)CC5)n4c3)c3ccccc32)cc1 CHEMBL5169767 IC50 0.5 nM
C[C@H]1CCCCC1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN5CCOCC5)c4)c4ccccc43)cn12 CHEMBL5202884 IC50 0.5 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cnn(CCN5CCOCC5)c4)c4ccccc43)cn12 CHEMBL5202397 IC50 0.5 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL2005792 pKi 0.5012 nM
CC(C)(C)N1CCC(c2cc3c(ccc(=O)n3-c3c(Cl)cccc3Cl)c(-c3ccc(F)cc3F)n2)CC1 CHEMBL199625 IC50 0.51 nM
CC(C)N1C2CCC1CC(c1cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c1)C2 CHEMBL380806 IC50 0.51 nM
CC(C)(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3cc[n+]([O-])c(-c4c(Cl)cccc4Cl)c3n2)CC1 CHEMBL1916520 IC50 0.53 nM
Cc1ccc(NC(=O)c2cc(F)cc(N3CCOCC3)c2)cc1Nc1ncnn2cc(C(=O)N[C@@H](C)c3ccccc3)c(C)c12 CHEMBL261845 Ki 0.54 nM
NCCC(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 CHEMBL403389 IC50 0.57 nM
CC(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3cc[n+]([O-])c(-c4c(Cl)cccc4Cl)c3n2)CC1 CHEMBL1916519 IC50 0.59 nM
O=C1NCc2c(-c3ccc(F)cc3Cl)cc(C3CCN(CC4CCC4)CC3)cc2N1c1c(Cl)cccc1Cl CHEMBL264627 pIC50 0.5998 nM
CC(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3c(c2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL328242 pIC50 0.5998 nM
O=C1NCc2c(-c3ccc(F)cc3F)cc(NC3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL96432 pIC50 0.5998 nM
CC(C)N1CCC(Nc2nc(-c3ccccc3Cl)c3c(n2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL377979 IC50 0.6 nM
CC(=O)Nc1noc2c(-c3ccc4c(N5CCOC[C@@H]5C)nncc4c3)c(C)ccc12 CHEMBL521860 Ki 0.6 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(OC(C)C)nncc2c1 CHEMBL493670 IC50 0.6 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(OC(C)C)cncc2c1 CHEMBL492266 IC50 0.6 nM
Cc1ccc(NC(=O)c2ccnc(NC3CCC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL477190 Ki 0.6 nM
CCn1c(=O)c(-c2cc(C(=O)NC3CC3)ccc2C)cc2cnn(-c3ccc(F)cc3F)c21 CHEMBL1089866 Ki 0.6 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1OC2 CHEMBL4064695 IC50 0.6 nM
O=C(NCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1CC2 CHEMBL4092372 IC50 0.6 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1CC2 CHEMBL4076170 IC50 0.6 nM
O=C(NCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1CC2 CHEMBL4071095 IC50 0.6 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)ccc3F)cc1CC2 CHEMBL4103539 IC50 0.6 nM
CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2cccc(CO)c2)n1 CHEMBL5183262 IC50 0.6 nM
CN(C)CCOc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)c1 CHEMBL5174266 IC50 0.6 nM
CN1CCN(Cc2ccc(-n3nc(C(C)(C)C)cc3NC(=O)N[C@H]3CC[C@@H](Oc4ccc5nnc(N6CCCCC6)n5c4)c4ccccc43)cc2)CC1 CHEMBL5185806 IC50 0.6 nM
CN1C2CCC1CC(c1cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c1)C2 CHEMBL200093 IC50 0.61 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CN2CCN[C@@H](C)C2)c1=O CHEMBL4750120 pIC50 0.631 nM
CC[C@@H](Nc1nccn(-c2cc(C(=O)NC3CC3)ccc2C)c1=O)c1ccccc1OCCN1CCCC1 CHEMBL4786381 pIC50 0.631 nM
CC1(c2nnc3ccc(-c4ocnc4-c4ccc(F)cc4F)cn23)CC1 CHEMBL211628 IC50 0.7 nM
CC1(C)CC(Nc2nc(-c3ccccc3Cl)c3c(n2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC(C)(C)N1 CHEMBL209442 IC50 0.7 nM
O=c1ccc2c(-c3ccccc3Cl)cc(O)cc2n1-c1c(Cl)cccc1Cl CHEMBL257236 IC50 0.7 nM
Cc1ccc2c(NC3CC3)noc2c1-c1ccc2c(N3CCOC[C@@H]3C)nncc2c1 CHEMBL522877 Ki 0.7 nM
COc1ccc(C(=O)NN2CCOCC2)cc1-c1n[nH]c2nc(Nc3ccc(F)cc3F)ccc12 CHEMBL512255 IC50 0.7 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OCCN4CCOCC4)cc2C3=O)ccc1F)c1cccs1 CHEMBL2316491 IC50 0.7 nM
Cc1cc(S(C)(=O)=O)ccc1-c1nncc2nc(Oc3ccc(F)cc3F)ccc12 CHEMBL3649497 IC50 0.7 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)cc1CC2 CHEMBL4102854 IC50 0.7 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1OC2 CHEMBL4103149 IC50 0.7 nM
CN1CCC(c2cc(-c3ccc(F)cc3Cl)c3cc[n+]([O-])c(-c4c(Cl)cccc4Cl)c3n2)CC1 CHEMBL1916361 IC50 0.72 nM
CC(C)(C)N1CC=C(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199593 IC50 0.74 nM
O=C1CCc2c(-c3ccc(F)cc3F)cc(C3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL564912 IC50 0.74 nM
O=C1CCc2ccccc2N1 CHEMBL388582 IC50 0.74 nM
O=C(NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)[C@@H]1CCCN1 CHEMBL409901 IC50 0.75 nM
CC(C)(C)N1CCC(Oc2cc(-c3ccc(F)cc3F)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199435 IC50 0.77 nM
CC(C)(C)CNc1nc(-c2ccccc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL214138 IC50 0.8 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1-c1ccc2c(C3CCNCC3)noc2c1 CHEMBL485286 Ki 0.8 nM
CC(=O)N1CCN(c2nncc3cc(-c4c(C)ccc5c(NC6CC6)noc45)ccc23)[C@@H](C)C1 CHEMBL495290 Ki 0.8 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(O[C@H](C)C(F)(F)F)nncc2c1 CHEMBL493708 IC50 0.8 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O CHEMBL1091929 Ki 0.8 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2c(cn1)C1(CCCC1)C(=O)N2 CHEMBL1825157 IC50 0.8 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(C(=O)N3CCCCC3)cc2)s1 CHEMBL2401995 IC50 0.8 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCC(C)(O)CC1 CHEMBL3701784 IC50 0.8 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)c1 CHEMBL4062023 IC50 0.8 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1CC2 CHEMBL4093914 IC50 0.8 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1CC2 CHEMBL4075759 IC50 0.8 nM
CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN(C)C)c4)c4ccccc43)cn12 CHEMBL5207264 IC50 0.8 nM
CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2cccc(CN3CCNCC3)c2)n1 CHEMBL5197124 IC50 0.8 nM
[O-][n+]1ccc2c(-c3ccc(F)cc3F)cc(C3CCNCC3)nc2c1-c1c(Cl)cccc1Cl CHEMBL1738839 IC50 0.82 nM
CC(C)(C(=O)O)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL200047 IC50 0.84 nM
O=C1NCc2c(-c3ccccc3Cl)cc(C3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL96763 pIC50 0.8995 nM
CC(C)n1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cc21 CHEMBL196210 IC50 0.9 nM
CNc1ncc2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL212128 IC50 0.9 nM
CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)ccc3C)c2c1C CHEMBL402489 IC50 0.9 nM
CCCNC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)ccc3C)c2c1C CHEMBL401164 IC50 0.9 nM
O=C(NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)[C@H]1CCCN1 CHEMBL256421 IC50 0.9 nM
Cc1ccc(NC(=O)c2ccccc2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL271760 IC50 0.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3ccccc3Cl)c2n(C)c1=O CHEMBL1089456 Ki 0.9 nM
Cn1c(=O)c(Nc2ccc(F)cc2F)cc2cnnc(-c3ccc(F)cc3F)c21 CHEMBL1254075 IC50 0.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCCCC1 CHEMBL1825143 IC50 0.9 nM
Cc1ccc(C(=O)Nc2ccon2)cc1-c1ccc2c(c1)NC(=O)C21CCC(F)(F)CC1 CHEMBL1825154 IC50 0.9 nM
Cc1ccc2c(NC3CC3)noc2c1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1911334 IC50 0.9 nM
Cc1cc(S(C)(=O)=O)ccc1-c1nncc2nc(Nc3ccc(F)cc3)ccc12 CHEMBL3649486 IC50 0.9 nM
Cc1ccccc1-c1nncc2nc(Oc3ccc(F)cc3)ccc12 CHEMBL3649499 IC50 0.9 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)C4CC4)c(F)cc3F)cc1CC2 CHEMBL4094105 IC50 0.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 CHEMBL494072 IC50 0.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnc(NC3CCOCC3)nc2n(C)c1=O CHEMBL1232751 IC50 0.9 nM
Fc1ccc(-c2n[nH]c(CCCc3ccccc3)c2-c2ccncc2)cc1 CHEMBL3310126 IC50 0.95 nM
CCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4cccc(N5CCOCC5)c4)ccc3C)c2c1C CHEMBL258748 Ki 0.98 nM
Nc1ccccc1Nc1ccc2c(c1)CCc1ccc(C(=O)NCCC(=O)O)cc1C2=O CHEMBL5074371 IC50 0.98 nM
COC(=O)c1cc(-c2ccccc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL94556 IC50 1.0 nM
C[C@H](O)CNc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cc2)ccn1 CHEMBL142425 IC50 1.0 nM
C[C@@H](O)CNc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cc2)ccn1 CHEMBL358537 IC50 1.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)cc1 CHEMBL420047 Kd 1.0 nM
COc1cc(-c2ccccc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL96632 IC50 1.0 nM
CN(C)CCN1CCN(c2nc(-c3ccc(Cl)cc3Cl)c3c(n2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL213142 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL429582 IC50 1.0 nM
Cc1ccc(NC(=O)c2cc(F)cc(N3CCOCC3)c2)cc1Nc1ncnn2cc(C(=O)O)c(C)c12 CHEMBL261007 IC50 1.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(O[C@@H](C)C(F)(F)F)nncc2c1 CHEMBL493671 IC50 1.0 nM
Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3F)c21 CHEMBL558448 IC50 1.0 nM
Cc1ccc(C(=O)Nc2ccon2)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O CHEMBL1092012 Ki 1.0 nM
COc1c(NC(=O)C(=O)c2ccc(Nc3ccncn3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O CHEMBL1208890 IC50 1.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(OCCN2CCOCC2)c2ccccc12 CHEMBL1213925 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)cc2)ccn1 CHEMBL1213974 IC50 1.0 nM
CC(=O)N1CCC(Nc2ncc3cc(Oc4ccc(F)cc4F)c(=O)n(C)c3n2)CC1 CHEMBL1766579 IC50 1.0 nM
CCn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1766498 IC50 1.0 nM
O=c1c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc2n1C1CCS(=O)(=O)CC1 CHEMBL1766503 IC50 1.0 nM
CS(=O)(=O)N1CCC(n2c(=O)c(Oc3ccc(F)cc3F)cc3cnc(NC4CCOCC4)nc32)CC1 CHEMBL1766572 IC50 1.0 nM
C[C@H](CS(C)(=O)=O)Nc1n[nH]c2nc(Oc3ccc(F)cc3F)ncc12 CHEMBL1236810 Kd 1.0 nM
Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(Cl)cccc1Cl CHEMBL1797202 IC50 1.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCN(S(C)(=O)=O)CC1 CHEMBL1825146 IC50 1.0 nM
CCn1c(=O)c(-c2cc(C(=O)NC3CC3)ccc2C)cc2nnc(-c3c(F)cccc3F)n21 CHEMBL1945722 IC50 1.0 nM
CCn1c(=O)c(-c2cc(C(=O)NC3CC3)ccc2C)cc2nnc(-c3c(F)cccc3Cl)n21 CHEMBL1945723 IC50 1.0 nM
CCn1c(=O)c(-c2cc(C(=O)NC3CC3)cc(F)c2C)cc2nnc(-c3c(C)cccc3F)n21 CHEMBL1945839 IC50 1.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OC[C@@H](O)CO)cc2C3=O)ccc1F)c1ccccc1 CHEMBL2316486 IC50 1.0 nM
O=C(OCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316206 IC50 1.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OCCN4CCOCC4)cc2C3=O)c(F)cc1F)c1ccccc1 CHEMBL2316497 IC50 1.0 nM
Cc1cc(F)c(NC(=O)c2ccoc2)cc1Nc1ccc2c(c1)CCc1ccc(OCCN3CCOCC3)cc1C2=O CHEMBL2316494 IC50 1.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OCCN4CCOCC4)cc2C3=O)ccc1F)c1ccoc1 CHEMBL2316489 IC50 1.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OCCN4CCOCC4)cc2C3=O)ccc1F)c1ccccc1 CHEMBL2316485 IC50 1.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)OCc2ccc(OCCN4CCOCC4)cc2C3=O)ccc1F)c1ccccc1 CHEMBL3086685 IC50 1.0 nM
Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cc(OCCC[C@H](N)C(=O)O)cc1F CHEMBL3220552 IC50 1.0 nM
C[C@H](Nc1nccc(-c2c(-c3ccc(F)cc3)nc3nc(N)ccn23)n1)c1ccccc1 CHEMBL3120970 IC50 1.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cc1 CHEMBL1090979 IC50 1.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)CN(C)C)c3)c3ccccc23)cc1 CHEMBL3781244 IC50 1.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCC(N2CCOCC2)CC1 CHEMBL3701785 IC50 1.0 nM
NCC[C@H](NCCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC1CCCC1 CHEMBL3981379 IC50 1.0 nM
C[C@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC(C)(C)C CHEMBL3965304 IC50 1.0 nM
CC(C)C[C@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC(C)(C)C CHEMBL3910819 IC50 1.0 nM
CC(C)C[C@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC1CCCC1 CHEMBL3220549 IC50 1.0 nM
CC(C)C[C@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)c(F)c1)C(=O)OC1CCCC1 CHEMBL3962988 IC50 1.0 nM
Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cc(CCN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1F CHEMBL3894052 IC50 1.0 nM
CC(C)(C)OC(=O)[C@@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)c1ccccc1 CHEMBL3932432 IC50 1.0 nM
CC(C)(C)OC[C@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC1CCCC1 CHEMBL3907977 IC50 1.0 nM
CC(C)(C)OC[C@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC(C)(C)C CHEMBL3923469 IC50 1.0 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1OC2 CHEMBL4095093 IC50 1.0 nM
O=C(NCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)cc1CC2 CHEMBL4079527 IC50 1.0 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1CC2 CHEMBL4061315 IC50 1.0 nM
Oc1ccc(-c2nc(-c3ccccc3)c(-c3ccnc4[nH]c(-c5ccccc5)cc34)[nH]2)cc1 CHEMBL4070454 IC50 1.0 nM
O=C(NC1CC1)c1ccc(Cl)c(Nc2nncc3c2cnn3-c2c(F)cccc2F)c1 CHEMBL1082158 Ki 1.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OC[C@H](O)CO)cc2C3=O)ccc1F)c1ccccc1 CHEMBL4575052 IC50 1.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCN(C)CC5)n4c3)c3ccccc32)cc1 CHEMBL5205402 IC50 1.0 nM
CNC(=O)c1ccc(C)c(-n2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)c1 CHEMBL1088751 IC50 1.05 nM
O=C1NCc2c(-c3ccc(F)cc3Cl)cc(C3CCN(C4CC4)CC3)cc2N1c1c(Cl)cccc1Cl CHEMBL96565 pIC50 1.099 nM
O=C(c1cc(-c2ccc(F)cc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2)N1CCNCC1 CHEMBL96225 pIC50 1.099 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cn1 CHEMBL104991 Kd 1.1 nM
CC1(c2nnc3ccc(-c4ocnc4-c4ccc(F)cc4F)cn23)CCC1 CHEMBL384795 IC50 1.1 nM
CC(C)(C)c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3F)cn12 CHEMBL212382 IC50 1.1 nM
CC(C)Nc1nc(-c2ccccc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL213895 IC50 1.1 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)OC)c(C)c23)c1 CHEMBL252127 IC50 1.1 nM
Cc1nc(-c2ccc(-c3cc(NC(=O)c4ccnc(N5CCCC5)c4)ccc3C)cc2)no1 CHEMBL521722 Ki 1.1 nM
CNc1noc2c(-c3ccc4c(C(C)C)nncc4c3)c(C)ccc12 CHEMBL492661 Ki 1.1 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N3CCOC[C@@H]3C)nncc2c1 CHEMBL494469 IC50 1.1 nM
CONC(=O)c1ccc(C)c(Nc2cc(=O)n(C)c3c2cnn3-c2ccc(F)cc2F)c1 CHEMBL563097 IC50 1.1 nM
CCn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3F)c21 CHEMBL550519 IC50 1.1 nM
Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3cc(F)ccc3F)c21 CHEMBL560390 IC50 1.1 nM
Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3c(F)cccc3F)c21 CHEMBL564054 IC50 1.1 nM
Cn1c(=O)c(-c2cc(C(=O)NC3CC3)ccc2Cl)cc2cnn(-c3c(F)cccc3F)c21 CHEMBL1091928 Ki 1.1 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1cc2nnc(-c3c(F)cccc3Cl)n2n(C)c1=O CHEMBL1945721 IC50 1.1 nM
Cc1n[nH]cc1-c1nncc2nc(Nc3ccc(F)cc3F)ccc12 CHEMBL3649492 IC50 1.1 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1CC2 CHEMBL4083921 IC50 1.1 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1CC2 CHEMBL4075277 IC50 1.1 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCOCC5)n4c3)c3ccccc32)cc1 CHEMBL5208101 IC50 1.1 nM
CCN1CCC(c2cc(-c3ccc(F)cc3Cl)c3c(c2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1 CHEMBL96345 pIC50 1.199 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(CCCN3CCOCC3)c3ccccc23)cc1 CHEMBL320950 Kd 1.2 nM
O=C1NCc2c(-c3ccccc3Cl)nc(NC3CN4CCC3CC4)nc2N1c1c(Cl)cccc1Cl CHEMBL212091 IC50 1.2 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NCc4ccccn4)c(C)c23)c1 CHEMBL252533 IC50 1.2 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(NC(=O)OC(C)C)c(C)c23)c1 CHEMBL254453 IC50 1.2 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(N3CCOCC3)nncc2c1 CHEMBL494272 IC50 1.2 nM
CCn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3)c21 CHEMBL562527 IC50 1.2 nM
C[C@H](CS(C)(=O)=O)Nc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1 CHEMBL1232769 Kd 1.2 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1800916 IC50 1.2 nM
Cc1ccc2c(N)noc2c1-c1ccc2c(c1)NC(=O)C21CCC(F)(F)CC1 CHEMBL1911342 IC50 1.2 nM
CCn1c(=O)c(-c2cc(C(=O)NC3CC3)cc(F)c2C)cc2nnc(-c3c(F)cccc3Cl)n21 CHEMBL1945726 IC50 1.2 nM
CC(C)C[C@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)O CHEMBL3220551 IC50 1.2 nM
Cc1ncccc1-c1nncc2nc(Nc3ccc(F)cc3F)ccc12 CHEMBL3649485 IC50 1.2 nM
Cc1ccc(C(N)=O)cc1-c1nncc2nc(Oc3ccc(F)cc3)ccc12 CHEMBL3649500 IC50 1.2 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1OC2 CHEMBL4084905 IC50 1.2 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)cc1CC2 CHEMBL4103781 IC50 1.2 nM
COC(=O)CCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5074857 IC50 1.2 nM
COC(=O)CC[C@H](NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2)C(=O)OC CHEMBL2316197 IC50 1.2 nM
CC[C@@H](Nc1nccn(-c2cc(C(=O)NC3CC3)ccc2C)c1=O)c1ccccc1 CHEMBL4779799 pIC50 1.259 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CN2CCOCC2)c1=O CHEMBL4790176 pIC50 1.259 nM
C[C@@H](C(=O)O)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199565 IC50 1.3 nM
COC(=O)C(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199316 IC50 1.3 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC(CCO)CCO)nc21 CHEMBL1090089 Kd 1.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1800911 IC50 1.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2nnc(-c3c(F)cccc3F)n2n(C)c1=O CHEMBL1945715 IC50 1.3 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1OC2 CHEMBL4076950 IC50 1.3 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1OC2 CHEMBL4090650 IC50 1.3 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)C4CC4)c(F)cc3F)cc1CC2 CHEMBL4103075 IC50 1.3 nM
CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC CHEMBL4868525 IC50 1.3 nM
O=C(NCCN1CCNCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5085015 IC50 1.3 nM
CC(C)(C)c1cc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCCC5)n4c3)c3ccccc32)n(-c2cccc(CN3CCCCC3)c2)n1 CHEMBL5175094 IC50 1.3 nM
O=C1NCc2c(-c3ccccc3Cl)cc(N3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL96487 IC50 1.4 nM
Fc1ccc(-c2ncn(C3CCNCC3)c2-c2ccnc(Nc3ccccc3)n2)cc1 CHEMBL97550 IC50 1.4 nM
CC(C)(C)N1CCC(c2cc3c(ccc(=O)n3-c3c(Cl)cccc3Cl)c(-c3ccccc3Cl)n2)CC1 CHEMBL424666 IC50 1.4 nM
Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1-c1ccc2c(C3CCNCC3)noc2c1 CHEMBL485285 Ki 1.4 nM
Cc1ccc(C(=O)NC2CC2)cc1Oc1cc(=O)n(C)c2c1cnn2-c1c(F)cccc1F CHEMBL560730 IC50 1.4 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3ccc(F)cc3F)c2n(C)c1=O CHEMBL1254901 IC50 1.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCC1 CHEMBL1800910 IC50 1.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)[C@]21CC[C@@H](O)CC1 CHEMBL1825151 IC50 1.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)[C@]21CC[C@H](O)CC1 CHEMBL1825152 IC50 1.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2nnc(-c3c(F)cccc3Cl)n2n(C)c1=O CHEMBL1945716 IC50 1.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCOCC1 CHEMBL1825147 IC50 1.4 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCC(O)CC1 CHEMBL3701783 IC50 1.4 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1OC2 CHEMBL4074639 IC50 1.4 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1CC2 CHEMBL4078249 IC50 1.4 nM
O=C(c1cc(-c2ccccc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2)N1CCNCC1 CHEMBL94444 IC50 1.5 nM
O[C@H]1CC[C@H](n2cnc(-c3ccc(F)cc3)c2-c2ccnc(Nc3ccccc3)n2)CC1 CHEMBL408876 IC50 1.5 nM
CC1(c2nnc3ccc(-c4ocnc4-c4cc(F)ccc4F)cn23)CCC1 CHEMBL439321 IC50 1.5 nM
CCOC(=O)Nc1cn2ncnc(Nc3cc(C(=O)NOC)ccc3C)c2c1C CHEMBL254452 IC50 1.5 nM
NC1(C(=O)NCCOc2cc(-c3ccccc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL270611 IC50 1.5 nM
COc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 CHEMBL403925 IC50 1.5 nM
Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3)c21 CHEMBL561932 IC50 1.5 nM
Cc1ccc(C(N)=O)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O CHEMBL1091930 Ki 1.5 nM
CC(C)COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1984842 pKi 1.585 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CN(C)C)c1=O CHEMBL4747984 pIC50 1.585 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CN2CCCCC2)c1=O CHEMBL4763279 pIC50 1.585 nM
CC(C)(C)N1CCC(Oc2cc(-c3ccccc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199707 IC50 1.6 nM
CC[C@@H](C)Nc1nc2ccc(-c3[nH]cnc3-c3ccccc3F)cc2s1 CHEMBL439238 IC50 1.6 nM
Cc1ccc(NC(=O)c2cccc(-c3ccoc3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL476996 Ki 1.6 nM
O=C(NC1CC1)c1ccc(Cl)c(Nc2nncc3c2cnn3-c2ccccc2Cl)c1 CHEMBL1076741 IC50 1.6 nM
Cc1nnc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3F)c12 CHEMBL1082206 IC50 1.6 nM
Cc1cnc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3cc(F)ccc3Cl)c2n(C)c1=O CHEMBL1254815 IC50 1.6 nM
CCn1c(=O)c(-c2cc(C(=O)NC3CC3)ccc2C)cc2nnc(-c3c(C)cccc3F)n21 CHEMBL1945724 IC50 1.6 nM
Cc1cc(F)c(NC(=O)c2ccsc2)cc1Nc1ccc2c(c1)OCc1ccc(OC[C@H](O)CO)cc1C2=O CHEMBL3087471 IC50 1.6 nM
Cc1n[nH]c(C)c1-c1nncc2nc(Nc3ccc(F)cc3F)ccc12 CHEMBL3649491 IC50 1.6 nM
O=C(NCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1OC2 CHEMBL4073776 IC50 1.6 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1OC2 CHEMBL4069033 IC50 1.6 nM
Cc1nnc(-c2ccc(-c3cc(NC(=O)c4ccnc(N5CCCC5)c4)ccc3C)c(C)c2)o1 CHEMBL495729 Ki 1.7 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1nncc2c1cnn2-c1c(F)cccc1F CHEMBL1081991 IC50 1.7 nM
Cc1nnc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3c(F)cccc3F)c12 CHEMBL1081208 IC50 1.7 nM
Cc1ccc(C(=O)NC2(C)CC2)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O CHEMBL1092011 Ki 1.7 nM
Cc1cc(F)c(NC(=O)c2ccsc2)cc1Nc1ccc2c(c1)OCc1ccc(OCCN3CCOCC3)cc1C2=O CHEMBL3087469 IC50 1.7 nM
O=C(NCCNCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5094430 IC50 1.7 nM
CC(C)(C)c1nnc2ccc(-c3ocnc3-c3cc(F)c(F)cc3F)cn12 CHEMBL212968 IC50 1.8 nM
COc1ccc(C(C)(C)C)cc1NC(=O)Nc1ccc(-c2ccc(CN3CCOCC3)nc2)c2ccccc12 CHEMBL523978 Kd 1.8 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cnc2c(c1)NC(=O)C21CCCC1 CHEMBL1825158 IC50 1.8 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCC(F)(F)CC1 CHEMBL1825153 IC50 1.8 nM
Cc1cc(F)c(NC(=O)c2ccsc2)cc1Nc1ccc2c(c1)OCc1ccc(OC[C@H]3COC(C)(C)O3)cc1C2=O CHEMBL3087470 IC50 1.8 nM
Cc1ccc(C(=O)Nc2cc(-c3c(-c4ccc(F)c(C)c4)nc4cccnn34)ccn2)cn1 CHEMBL4227523 IC50 1.8 nM
Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cccc1F CHEMBL3220548 IC50 1.86 nM
O=C1NCc2c(-c3ccccc3Cl)nc(N3CCc4n[nH]cc4C3)nc2N1c1c(Cl)cccc1Cl CHEMBL213986 IC50 1.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(NCCN3CCOCC3)nncc2c1 CHEMBL494270 IC50 1.9 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL515466 Ki 1.9 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL477182 Ki 1.9 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1cc(=O)n(C)c2c1cnn2-c1c(F)cccc1F CHEMBL558912 IC50 1.9 nM
Cn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2F)c2cnn(-c3c(F)cccc3F)c21 CHEMBL559242 IC50 1.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3ccccc3C)c2n(C)c1=O CHEMBL1089122 Ki 1.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3cc(F)ccc3F)c2n(C)c1=O CHEMBL1089534 Ki 1.9 nM
CCn1c(=O)c(-c2cc(C(=O)NC3CC3)cc(F)c2C)cc2nnc(-c3c(F)cccc3F)n21 CHEMBL1945725 IC50 1.9 nM
CC(C)(C)OC(=O)N1CCN(CCNC(=O)c2ccc3c(c2)C(=O)c2ccc(Nc4ccccc4N)cc2CC3)CC1 CHEMBL5086455 IC50 1.9 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CN2CCN(C)CC2)c1=O CHEMBL4757835 pIC50 1.995 nM
Cc1cc(F)ccc1-c1cc(N(C(N)=O)c2c(Cl)cccc2Cl)ccc1CO CHEMBL62794 IC50 2.0 nM
O=C1NCc2c(-c3ccccc3Cl)cc(O)cc2N1c1c(Cl)cccc1Cl CHEMBL210110 IC50 2.0 nM
CNc1nc(-c2ccccc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL425785 IC50 2.0 nM
COCCNc1nc(-c2ccc(Cl)cc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL213836 IC50 2.0 nM
O=C1NCc2c(-c3ccccc3Cl)nc(N3CCOCC3)nc2N1c1c(Cl)cccc1Cl CHEMBL378717 IC50 2.0 nM
C[C@@H]1CN(c2nc(-c3ccc(Cl)cc3Cl)c3c(n2)N(c2c(Cl)cccc2Cl)C(=O)NC3)C[C@H](C)O1 CHEMBL211303 IC50 2.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL212964 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NC3CC3)ncc2c1 CHEMBL212181 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NC3CCN(C)CC3)ncc2c1 CHEMBL215691 IC50 2.0 nM
CCCNc1ncc(C(=O)Nc2cc(C(=O)NCC)ccc2C)s1 CHEMBL255482 IC50 2.0 nM
Cc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL405666 IC50 2.0 nM
COC[C@H](C)NC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4cc(F)cc(N5CCOCC5)c4)ccc3C)c2c1C CHEMBL260411 IC50 2.0 nM
CCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4ccnc(N5CCOCC5)c4)ccc3C)c2c1C CHEMBL262608 IC50 2.0 nM
CCOC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4cc(F)cc(N5CCOCC5)c4)ccc3C)c2c1C CHEMBL260447 IC50 2.0 nM
OCCSc1nc(-c2ccc(F)cc2)c(-c2ccnc(N[C@H]3CC[C@H](O)CC3)c2)[nH]1 CHEMBL492255 IC50 2.0 nM
OCCSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC3CCOCC3)c2)[nH]1 CHEMBL492296 IC50 2.0 nM
Cc1ccc2c(N)nsc2c1-c1ccc2c(N3CCOC[C@@H]3C)nncc2c1 CHEMBL524054 Ki 2.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(-c3ccccc3)nncc2c1 CHEMBL495330 IC50 2.0 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCCC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL476141 IC50 2.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCc2cccc(NS(C)(=O)=O)c2)cc1 CHEMBL479028 Ki 2.0 nM
CNc1noc2c(-c3cc4cnn(-c5c(F)cccc5F)c4n(C)c3=O)c(C)ccc12 CHEMBL1089513 Ki 2.0 nM
COc1c(NC(=O)C(=O)c2ccc(Nc3ccncc3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O CHEMBL1208891 IC50 2.0 nM
CNC(=O)NCc1ccccc1-c1cc(-c2cnc(NC(C)C)s2)nc(NCCN(C)C)n1 CHEMBL1257245 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccon2)cc1NC(=O)c1cnn(-c2ccccn2)c1N CHEMBL1290626 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccon2)cc1NC(=O)c1cnn(-c2ccccc2F)c1N CHEMBL1290746 IC50 2.0 nM
CCn1nccc1NC(=O)c1ccc(C)c(NC(=O)c2cnn(-c3ccc(F)cc3)c2N)c1 CHEMBL1289077 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccon2)cc1NC(=O)c1cnn(-c2ccc(F)cc2)c1N CHEMBL1289078 IC50 2.0 nM
CCCCn1ncc(C(=O)Nc2cc(C(=O)Nc3ccon3)ccc2C)c1N CHEMBL1289197 IC50 2.0 nM
C[C@@H](Cn1ncnn1)Nc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1 CHEMBL1232784 IC50 2.0 nM
O=c1c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc2n1CCCO CHEMBL1766500 IC50 2.0 nM
N#CCn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1766506 IC50 2.0 nM
CC(C)Nc1cc(-c2[nH]c([S+](C)[O-])nc2-c2ccc(F)cc2)ccn1 CHEMBL1773433 IC50 2.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC(C)C)c2)[nH]1 CHEMBL1773432 IC50 2.0 nM
Cc1cccc(C)c1-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O CHEMBL1797203 IC50 2.0 nM
Cc1ccc(C(N)=O)cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O CHEMBL1802632 IC50 2.0 nM
O=C(NC1CC1)c1ccc(Cl)c(-c2ccc3c(c2)NC(=O)C32CCCC2)c1 CHEMBL1800913 IC50 2.0 nM
Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCC(F)(F)CC3)c2)[nH]1 CHEMBL1911332 IC50 2.0 nM
CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc(F)c(Cl)c2Cl)s1 CHEMBL1929230 IC50 2.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2nnc(-c3c(C)cccc3F)n2n(C)c1=O CHEMBL1945717 IC50 2.0 nM
O=C(OCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316205 IC50 2.0 nM
COC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316201 IC50 2.0 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316479 IC50 2.0 nM
CSCCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316474 IC50 2.0 nM
O=C(NCCF)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316472 IC50 2.0 nM
CC1(C)OC[C@H](COc2ccc3c(c2)C(=O)c2ccc(Nc4ccc(F)c(NC(=O)c5cccs5)c4)cc2CC3)O1 CHEMBL2316492 IC50 2.0 nM
O=C(Nc1ccc(F)c(Nc2ccc3c(c2)CCc2ccc(OCCO)cc2C3=O)c1)c1ccccc1 CHEMBL2316488 IC50 2.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OCCO)cc2C3=O)ccc1F)c1ccccc1 CHEMBL2316483 IC50 2.0 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(Cl)cc2)s1 CHEMBL2401981 IC50 2.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccccc2)n1 CHEMBL1214131 IC50 2.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)s1 CHEMBL3695593 IC50 2.0 nM
Cc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695578 IC50 2.0 nM
CCn1c(=O)[nH]c2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(OC)cc4)c4ccccc34)c21 CHEMBL3695584 IC50 2.0 nM
Cc1ccc(-n2nc(C3CC3)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695576 IC50 2.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c(Cl)c2Cl)n(-c2ccc(CO)cc2)n1 CHEMBL3695591 IC50 2.0 nM
CC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781102 IC50 2.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)CN4CCOCC4)c3)c3ccccc23)cc1 CHEMBL3780667 IC50 2.0 nM
CSCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781245 IC50 2.0 nM
CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)c3)c3ccccc23)n(-c2cccc(OCCN3CCOCC3)c2)n1 CHEMBL3925985 IC50 2.0 nM
CC(C)C[C@H](NCCCCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC(C)(C)C CHEMBL3911381 IC50 2.0 nM
CC(C)C[C@H](NCCCCCOc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC1CCCC1 CHEMBL3901931 IC50 2.0 nM
CC(C)C[C@@H](NCCc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)c(F)c1)C(=O)OC(C)(C)C CHEMBL4110632 IC50 2.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1C CHEMBL4086457 IC50 2.0 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1OC2 CHEMBL4082844 IC50 2.0 nM
OCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1 CHEMBL4101719 IC50 2.0 nM
OCCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1 CHEMBL4089892 IC50 2.0 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnn(-c2ccccc2)c1N CHEMBL1290404 IC50 2.0 nM
C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN(C)C)n4)c4ccccc43)cn12 CHEMBL5185814 IC50 2.0 nM
Cn1c(NC[C@@H](N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL585902 EC50 2.06 nM
Cc1ccc(NC(=O)c2cccc(-n3c(C)ccc3C)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL476995 Ki 2.1 nM
O=C(NC1CC1)c1ccc(Cl)c(Nc2nncc3c2cnn3-c2cc(F)ccc2F)c1 CHEMBL1081990 IC50 2.1 nM
Cc1cnc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3ccccc3Cl)c2n(C)c1=O CHEMBL1254648 IC50 2.1 nM
COC(=O)[C@@H](N)CCCCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5082978 IC50 2.1 nM
CC(C)(C)N1CCC(Oc2cc(-c3ccc(F)cc3F)c3ccc(=O)n(-c4c(F)cccc4F)c3c2)CC1 CHEMBL200534 IC50 2.2 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccc(Cl)cc3F)cn12 CHEMBL379590 IC50 2.2 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)N[C@@H](C)c4ccccc4)c(C)c23)c1 CHEMBL252535 IC50 2.2 nM
COCCNC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)ccc3C)c2c1C CHEMBL252336 IC50 2.2 nM
Cn1c(=O)c(Nc2ccc(F)cc2)cc2cnnc(-c3ccc(F)cc3F)c21 CHEMBL1254074 IC50 2.2 nM
Cc1cc(-c2nc3cccnn3c2-c2ccnc(NC(=O)c3cccnc3)c2)ccc1F CHEMBL4229137 IC50 2.2 nM
Cc1cc(C)cc(Nc2nccc(-c3c(-c4ccc(F)cc4)nnn3C3CCNCC3)n2)c1 CHEMBL4475135 Kd 2.2 nM
CC1(c2nnc3ccc(-c4ocnc4-c4cc(F)c(F)cc4F)cn23)CC1 CHEMBL215899 IC50 2.3 nM
CC[C@H](C)Nc1ncc(C(=O)Nc2cc(C(=O)NC)ccc2C)s1 CHEMBL258203 IC50 2.3 nM
CC(C)(C)Cn1cnc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccc(F)cc3F)nc21 CHEMBL270657 IC50 2.3 nM
Cc1nnc(Nc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3ccc(F)cc3)c12 CHEMBL1076560 IC50 2.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3ncccc3C(F)(F)F)c2n(C)c1=O CHEMBL1089457 Ki 2.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cnc2c(c1)NC(=O)C21CCC(F)(F)CC1 CHEMBL1825160 IC50 2.3 nM
COC(=O)[C@@H](N)CCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5093265 IC50 2.3 nM
O=C(c1cc(-c2ccc(F)cc2F)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2)N1CCNCC1 CHEMBL327217 pIC50 2.399 nM
CC(C)(C)N1CCC(Oc2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL381201 IC50 2.4 nM
CNc1ncc(C(=O)Nc2cc(C(=O)Nc3cccc(C(F)(F)F)c3F)ccc2C)c(NC)n1 CHEMBL269936 IC50 2.4 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1-c1ccc2cc[nH]c(=O)c2c1 CHEMBL498390 Ki 2.4 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)C4CC4)c(F)cc3F)cc1CC2 CHEMBL4088396 IC50 2.4 nM
CC(C)(C)OC(=O)N1CCN(CCNC(=O)c2ccc3c(c2)C(=O)c2ccc(Nc4ccc(F)cc4F)cc2CC3)CC1 CHEMBL5094431 IC50 2.4 nM
O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5093965 IC50 2.4 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1C(=O)O CHEMBL420474 Kd 2.5 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3Cl)cn12 CHEMBL215652 IC50 2.5 nM
CC1(c2nnc3ccc(-c4ocnc4-c4cc(F)c(F)cc4F)cn23)CCC1 CHEMBL213159 IC50 2.5 nM
CC(C)Cn1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)nc21 CHEMBL442972 IC50 2.5 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccn2c(-c3c(F)cccc3F)nnc2c1 CHEMBL1945591 IC50 2.5 nM
O=C(NC1(c2ccccc2)CC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5080423 IC50 2.5 nM
NCCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5080798 IC50 2.5 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(N[C@@H](c2ccccc2)[C@@H](C)CO)c1=O CHEMBL4756277 pIC50 2.512 nM
COC(=O)C(C)(C)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL199632 IC50 2.59 nM
O=C1NCc2c(-c3ccc(F)cc3F)cc(N3CCNCC3)cc2N1c1c(Cl)cccc1Cl CHEMBL94417 IC50 2.6 nM
Cc1ccc(C(N)=O)cc1Nc1cc(=O)n(C)c2c1cnn2-c1ccc(F)cc1F CHEMBL552271 IC50 2.6 nM
Cn1c(=O)c(-c2cc(C(=O)NC3CC3)ccc2Cl)cc2cnnc(-c3ccc(F)cc3F)c21 CHEMBL1254900 IC50 2.6 nM
O=C(NC(CO)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1OC2 CHEMBL4066610 IC50 2.6 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1OC2 CHEMBL4077412 IC50 2.6 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(C4CCNCC4)nc3-c3ccccc3)cc21 CHEMBL191113 IC50 2.7 nM
CC[C@H](C)Nc1nc2ccc(-c3[nH]cnc3-c3ccccc3F)cc2s1 CHEMBL255469 IC50 2.7 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1nnc(C)c2c1cnn2-c1ccc(F)cc1F CHEMBL1080673 IC50 2.7 nM
Cc1ccc(C(N)=O)cc1-c1cc2cnnc(-c3ccc(F)cc3F)c2n(C)c1=O CHEMBL1255074 IC50 2.7 nM
CNC(=O)c1ccc(C)c(-c2cc3cnnc(-c4ccc(F)cc4F)c3n(C)c2=O)c1 CHEMBL1255073 IC50 2.7 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3ccc(F)cc3F)c2n(C)c1=O CHEMBL1254989 IC50 2.7 nM
Cc1cnc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3ccccc3C)c2n(C)c1=O CHEMBL1254647 IC50 2.7 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1OC2 CHEMBL4081874 IC50 2.7 nM
Cc1cc(-c2nc3cccnn3c2-c2ccnc(NC(=O)c3ccc(C)[n+]([O-])c3)c2)ccc1F CHEMBL4225133 IC50 2.7 nM
O=C(Cc1ccccc1Cl)Nc1onc(-c2ccc(F)cc2F)c1-c1ccncn1 CHEMBL3310146 IC50 2.73 nM
CC(C)c1nnc2ccc(-c3c[nH]nc3-c3cc(F)ccc3F)cn12 CHEMBL214198 IC50 2.8 nM
Cc1nnc(-c2ccc(-c3cc(C(=O)Nc4cccc(N5CCOCC5)c4)ccc3C)c(C)c2)o1 CHEMBL523559 Ki 2.8 nM
O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl CHEMBL119385 Kd 2.8 nM
Cc1cccc(F)c1-c1nnc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)c(=O)n(C)n12 CHEMBL1944649 IC50 2.8 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2cnccc2N2CCOCC2)s1 CHEMBL2402000 IC50 2.8 nM
COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)ccc1C(=O)O CHEMBL3915286 Kd 2.8 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)[nH]c(-c3cccs3)nc2c1 CHEMBL525727 Ki 2.9 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1cc(=O)n(C)c2c1cnn2-c1cc(F)ccc1F CHEMBL563941 IC50 2.9 nM
Cc1cnc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3ccc(C(F)(F)F)cc3F)c2n(C)c1=O CHEMBL1254814 IC50 2.9 nM
COc1cc(-c2ccc(F)cc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL94770 pIC50 2.999 nM
CN1CCC(n2cnc(-c3ccc(F)cc3)c2-c2ccnc(Nc3ccccc3)n2)CC1 CHEMBL318892 IC50 3.0 nM
OCCNc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cc2)ccn1 CHEMBL143476 IC50 3.0 nM
CCC(O)CNc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cc2)ccn1 CHEMBL142367 IC50 3.0 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC3CCCC3)c2)s1 CHEMBL197912 IC50 3.0 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccccc3Cl)cn12 CHEMBL212294 IC50 3.0 nM
CC1(c2nnc3ccc(-c4ocnc4-c4cc(F)ccc4F)cn23)CC1 CHEMBL377319 IC50 3.0 nM
CN(C)c1nc(-c2ccccc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL441853 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 CHEMBL215943 IC50 3.0 nM
CC[C@H](C)NC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)ccc3C)c2c1C CHEMBL401210 IC50 3.0 nM
Cc1ccc(NC(=O)c2cc(F)cc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL407063 IC50 3.0 nM
CNC(=O)c1ccc(C)c(Nc2nc(N)nc3c2cnn3-c2ccccc2)c1 CHEMBL261021 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc[nH]n2)cc1Nc1ncnc2c1cnn2-c1ccccc1 CHEMBL410136 IC50 3.0 nM
Cc1ccc(NC(=O)c2cc(F)cc(N3CCOCC3)c2)cc1Nc1ncnn2cc(C(N)=O)c(C)c12 CHEMBL261006 IC50 3.0 nM
CC(C)Nc1cc(-c2[nH]c(SCCO)nc2-c2ccc(F)cc2)ccn1 CHEMBL521637 IC50 3.0 nM
CC(C)Nc1cc(-c2[nH]c(SC[C@@H](O)CO)nc2-c2ccc(F)cc2)ccn1 CHEMBL462265 IC50 3.0 nM
OCC(O)CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC3CCOCC3)c2)[nH]1 CHEMBL459926 IC50 3.0 nM
CC(C)Nc1cc(-c2[nH]c(SCC(O)CO)nc2-c2ccc(F)cc2)ccn1 CHEMBL459716 IC50 3.0 nM
COCCn1c(SC)nc(-c2ccc(F)cc2)c1-c1ccnc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL481952 IC50 3.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(N[C@H]3CC[C@H](O)CC3)c2)[nH]1 CHEMBL516607 IC50 3.0 nM
Cc1ccc(NC(=O)c2ccnc(NC3CCCCC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL477191 Ki 3.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCc2ccc(N3CCN(C)CC3)cc2)cc1 CHEMBL516127 Ki 3.0 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1nncc2c1cnn2-c1ccc(F)cc1F CHEMBL1088443 IC50 3.0 nM
Cc1ccc(C(=O)NC2CC2)cc1Oc1nncc2c1cnn2-c1c(F)cccc1F CHEMBL1082159 IC50 3.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC(=O)/C=C/c3c(Cl)cccc3Cl)c2)[nH]1 CHEMBL1271501 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccon2)cc1NC(=O)c1cnn(-c2ccccc2)c1N CHEMBL1234931 IC50 3.0 nM
CCn1nccc1NC(=O)c1ccc(C)c(NC(=O)c2cnn(-c3ccccc3F)c2N)c1 CHEMBL1290627 IC50 3.0 nM
CC(C)Nc1cc(-c2[nH]c([S+]([O-])C(C)C)nc2-c2ccc(F)cc2)ccn1 CHEMBL1773437 IC50 3.0 nM
Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cccc1F CHEMBL1797123 IC50 3.0 nM
Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cc(OCC(N)=O)cc1F CHEMBL1797209 IC50 3.0 nM
CNC(=O)c1ccc(Cl)c(-n2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)c1 CHEMBL1802637 IC50 3.0 nM
Cc1ccc(C(=O)NCC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1800921 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccon2)cc1Nc1ncnn2cc(C(=O)c3ccccc3)c(C)c12 CHEMBL1807447 IC50 3.0 nM
COC(=O)NC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)c4ccccc4)c(C)c23)c1 CHEMBL1807448 IC50 3.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)cc(F)c2Oc2ccnc(N3CCOCC3)n2)cc1 CHEMBL2058051 IC50 3.0 nM
Cc1cc(F)c(NC(=O)c2ccsc2)cc1Nc1ccc2c(c1)CCCCC2=O CHEMBL2182085 IC50 3.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccnc4[nH]c(-c5ccccc5)cc34)[nH]2)cc1 CHEMBL2179119 IC50 3.0 nM
CCOC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316202 IC50 3.0 nM
CN(C)CCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316481 IC50 3.0 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316477 IC50 3.0 nM
CS(=O)(=O)CCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316476 IC50 3.0 nM
O=C(NCCCl)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316473 IC50 3.0 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316470 IC50 3.0 nM
O=C(Nc1ccc(F)c(Nc2ccc3c(c2)OCc2ccc(OCCN4CCOCC4)cc2C3=O)c1)c1ccccc1 CHEMBL3086686 IC50 3.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL1214134 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(Cl)cc2)n1 CHEMBL3695575 IC50 3.0 nM
Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccccc4)c4ccccc34)ccnc2[nH]c1=O CHEMBL1214132 IC50 3.0 nM
COCC(=O)Nc1cnccc1CCOc1ccc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(C)cc2)c2ccccc12 CHEMBL3782036 IC50 3.0 nM
COc1c(CO)cc(C(C)(C)C)cc1NC(=O)N[C@@H]1Cc2c(F)cccc2[C@@H]1O CHEMBL3652531 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3cc(Nc4ccc5[nH]ncc5c4)ncn3)c3ccccc23)n(-c2ccc(=O)n(CCO)c2)n1 CHEMBL3899497 IC50 3.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)cc1 CHEMBL4082212 IC50 3.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c(C)c2)c1 CHEMBL4092555 IC50 3.0 nM
O=C(NC(CO)(CO)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1OC2 CHEMBL4071599 IC50 3.0 nM
O=C(Cc1ccc(F)cc1)Nc1cc(-c2[nH]c(SCc3ccccc3)nc2-c2ccc(F)cc2)ccn1 CHEMBL4452170 IC50 3.0 nM
O=C(NC(CO)(CO)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5078955 IC50 3.0 nM
COC(=O)[C@H](C)NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5084842 IC50 3.0 nM
CCNC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)ccc3C)c2c1C CHEMBL252128 IC50 3.1 nM
Cc1ccc(C(=O)NC2(C)CC2)cc1-c1cc2cnnc(-c3ccc(F)cc3F)c2n(C)c1=O CHEMBL1254988 IC50 3.1 nM
Cc1cnc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3ccc(F)cc3C)c2n(C)c1=O CHEMBL1254732 IC50 3.1 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1996500 pKi 3.162 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 3.162 nM
NC(=O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL199136 IC50 3.2 nM
C[C@H](C(=O)O)N1CCC(c2cc(-c3ccc(F)cc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 CHEMBL200018 IC50 3.2 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3cc(F)c(F)cc3F)cn12 CHEMBL213423 IC50 3.2 nM
CC[C@@H](C)Nc1nc2ccc(-c3c(-c4ccccc4F)n[nH]c3N)cc2s1 CHEMBL404115 IC50 3.2 nM
Cc1ccc(C(N)=O)cc1NC(=O)c1cnc(NC(C)C)s1 CHEMBL257995 IC50 3.2 nM
CC(C)(C)Cn1cnc2ccc(-c3[nH]c(-c4c(F)cccc4Cl)nc3-c3ccccc3)nc21 CHEMBL409698 IC50 3.2 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1cc(=O)n(C)c2c1cnn2-c1ccc(F)cc1F CHEMBL559401 IC50 3.2 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(NC(=O)OC)c(C)c23)c1 CHEMBL252569 IC50 3.3 nM
CC(C)Nc1nc2ccc(-c3[nH]cnc3-c3ccccc3F)cc2s1 CHEMBL403942 IC50 3.3 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1cc(=O)n(C)c2c1cnn2-c1cccc(F)c1 CHEMBL559403 IC50 3.3 nM
Cn1c(=O)cc(Oc2cc(C(=O)NC3CC3)ccc2Cl)c2cnn(-c3cc(F)ccc3F)c21 CHEMBL558711 IC50 3.3 nM
O=C(NC1CC1)c1ccc(Cl)c(Nc2nncc3c2cnn3-c2ccc(F)cc2F)c1 CHEMBL1088032 IC50 3.3 nM
CCNC(=O)NCc1ccccc1Sc1ccc2nnc(C(C)C)n2c1 CHEMBL1938764 Kd 3.3 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnn(-c2ncccc2C(F)(F)F)c1C CHEMBL2401979 Kd 3.3 nM
CS(=O)(=O)N1CCC[C@H](NC(=O)[C@H](CCC2CCCCC2)NC(=O)c2ccc(CNC(=O)c3cnn(-c4ccccc4)c3N)cc2)C1 CHEMBL5081039 IC50 3.3 nM
CC(C)c1cc(NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)n(-c2ccccc2)n1 CHEMBL105248 Kd 3.4 nM
CCNC(=O)c1ccc(C)c(NC(=O)c2cnc(NC(C)C)s2)c1 CHEMBL255698 IC50 3.4 nM
Cc1ccc(NC(=O)c2ccc(C#N)cc2)cc1Nc1ncnn2cc(C(=O)N[C@@H](C)c3ccccc3)c(C)c12 CHEMBL259596 Ki 3.4 nM
COC(=O)CCCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5081438 IC50 3.4 nM
CC(C)(C)c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL379394 IC50 3.5 nM
Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CC4)n3c2)c(F)c1 CHEMBL212898 IC50 3.5 nM
CC[C@@H](C)Nc1ncc(C(=O)Nc2cc(C(=O)NC)ccc2C)s1 CHEMBL258202 IC50 3.5 nM
CNC(=O)c1ccc(C)c(NC(=O)c2cnc(NC(C)C)s2)c1 CHEMBL258201 IC50 3.5 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)nc21 CHEMBL272108 IC50 3.5 nM
Fc1ccc(Nc2ccc3c(-c4cn[nH]c4)nncc3n2)c(F)c1 CHEMBL3649490 IC50 3.5 nM
O=C(NCC(F)(F)F)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5080807 IC50 3.5 nM
N[C@@H](CCCCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2)C(=O)O CHEMBL5076216 IC50 3.5 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(NC(C)=O)c(C)c23)c1 CHEMBL252946 IC50 3.6 nM
CC(C)(C)Cn1cnc2ccc(-c3[nH]c(-c4c(Cl)cccc4Cl)nc3-c3ccc(F)cc3)nc21 CHEMBL274201 IC50 3.6 nM
Cc1cccc(-c2noc(NC(=O)Cc3ccccc3Cl)c2-c2ccncn2)c1 CHEMBL3310149 IC50 3.62 nM
O=C(NCCCN1CCOCC1)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL198687 IC50 3.7 nM
CC(C)Nc1nc2ccc(-c3c(-c4ccccc4F)n[nH]c3N)cc2s1 CHEMBL255470 IC50 3.7 nM
CC(C)Cn1cnc2ccc(-c3[nH]c(-c4c(Cl)cccc4Cl)nc3-c3ccccc3)nc21 CHEMBL429422 IC50 3.7 nM
Cc1ccc(C(N)=O)cc1Nc1cc(=O)n(C)c2c1cnn2-c1cc(F)ccc1F CHEMBL550798 IC50 3.7 nM
NC(=O)c1ccc(N(C(N)=O)c2c(F)cccc2F)nc1-c1ccc(F)cc1F CHEMBL1090090 Kd 3.7 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4cccc(Cl)c4)cc3)N=C2c2ccccc2)c1 CHEMBL3577634 IC50 3.7 nM
Nc1c(C(=O)NCc2ccc(C(=O)NCCCC3CCCCC3)cc2)cnn1-c1ccccc1 CHEMBL4436748 IC50 3.7 nM
Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)c(F)c1 CHEMBL379374 IC50 3.75 nM
Cc1ccc(C(=O)Nc2ccon2)cc1NC(=O)c1cnc(NC(C)C)s1 CHEMBL403200 IC50 3.8 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(C(=O)N(C)C)cc2)s1 CHEMBL2401993 IC50 3.8 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)s1 CHEMBL2401985 IC50 3.8 nM
CC(C)Cn1cnc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccc(F)cc3F)nc21 CHEMBL271505 IC50 3.9 nM
CC(C)Cn1cnc2ccc(-c3[nH]c(-c4c(Cl)cccc4Cl)nc3-c3ccc(F)cc3F)nc21 CHEMBL272731 IC50 3.9 nM
Cc1cnc(C(=O)NC2CC2)cc1-c1cc2cnnc(-c3ccccc3C(F)(F)F)c2n(C)c1=O CHEMBL1254731 IC50 3.9 nM
CCCNC(=O)c1cn2ncnc(Nc3cc(C(=O)Nc4ccon4)ccc3C)c2c1C CHEMBL1230070 IC50 3.9 nM
O=C(NC1CCNCC1)c1cccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL194806 pIC50 3.981 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL1784164 pKi 3.981 nM
Cc1cc(F)ccc1Nc1ccc(C(=O)c2ccccc2C)c(Cl)c1 CHEMBL152208 IC50 4.0 nM
O=C1NCc2c(-c3ccccc3Cl)nc(O)nc2N1c1c(Cl)cccc1Cl CHEMBL213846 IC50 4.0 nM
O=C1NCc2c(-c3ccccc3Cl)nc(NN3CCOCC3)nc2N1c1c(Cl)cccc1Cl CHEMBL215651 IC50 4.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4N4CCN(C)C4=O)ccc3C)ccc2n1 CHEMBL385598 IC50 4.0 nM
CCONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)OC)c(C)c23)c1 CHEMBL251928 IC50 4.0 nM
O=C1C(O)Cc2c(-c3ccccc3Cl)cc(O)cc2N1c1c(Cl)cccc1Cl CHEMBL270599 IC50 4.0 nM
COc1cc(OC)cc(C(=O)Nc2ccc(C)c(C(=O)Nc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc3)c2)c1 CHEMBL272850 IC50 4.0 nM
CONC(=O)c1ccc(C)c(Nc2ncnc3c2cnn3-c2ccccc2)c1 CHEMBL259007 IC50 4.0 nM
CNC(=O)c1ccc(C)c(Nc2nc(NCCN3CCCC3)nc3c2cnn3-c2ccccc2)c1 CHEMBL409916 IC50 4.0 nM
CNC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4cc(F)cc(N5CCOCC5)c4)ccc3C)c2c1C CHEMBL261005 IC50 4.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(C3CCNCC3)noc2c1 CHEMBL497563 Ki 4.0 nM
COC(=O)CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC(C)C)c2)[nH]1 CHEMBL522486 IC50 4.0 nM
COc1cccc(CNC(=O)c2ccc(-c3cc(C(=O)NC4CC4)ccc3C)cc2)c1 CHEMBL517671 Ki 4.0 nM
CCn1c(=O)cc(Nc2cc(C(=O)NC3CC3)ccc2C)c2cnn(-c3ccc(F)cc3)c21 CHEMBL559597 IC50 4.0 nM
CCn1c(=O)cc(Oc2cc(C(=O)NC3CC3)ccc2C)c2cnn(-c3ccc(F)cc3)c21 CHEMBL562528 IC50 4.0 nM
C[C@H](Nc1nccc(N(CCCCN)C(=O)c2ccc3c(c2)CCO3)n1)c1ccccc1 CHEMBL1093548 IC50 4.0 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(-c3ccccn3)n2)s1 CHEMBL1258633 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccnn2C)cc1NC(=O)c1cnn(-c2ccccc2F)c1N CHEMBL1290745 IC50 4.0 nM
CCNc1c(C(=O)Nc2cc(C(=O)Nc3ccon3)ccc2C)cnn1-c1ccccn1 CHEMBL1289426 IC50 4.0 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 IC50 4.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL1766580 IC50 4.0 nM
CC(C)Nc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1 CHEMBL1232772 IC50 4.0 nM
CC(C)Nc1cc(-c2[nH]c([S@+]([O-])C(C)C)nc2-c2ccc(F)cc2)ccn1 CHEMBL1773438 IC50 4.0 nM
CC(C)Nc1cc(-c2[nH]c(SC(C)C)nc2-c2ccc(F)cc2)ccn1 CHEMBL1773436 IC50 4.0 nM
Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F CHEMBL1797124 IC50 4.0 nM
CNC(=O)c1ccc(C)c(-n2c(CO)cc(OCc3ccc(F)cc3F)c(Br)c2=O)c1 CHEMBL1802641 IC50 4.0 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1ncnn2cc(C(=O)c3ccccc3)c(C)c12 CHEMBL1807446 IC50 4.0 nM
O=C1Nc2cc(-c3cccc4c(NC5CC5)noc34)c(Cl)cc2C12CCCC2 CHEMBL1911336 IC50 4.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccnc(N3CCOCC3)n2)cc1 CHEMBL2058047 IC50 4.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccccc2C3=O)ccc1F)c1ccoc1 CHEMBL2182072 IC50 4.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccccc2C3=O)c(F)cc1F)c1ccccc1 CHEMBL2316208 IC50 4.0 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(N)cc2)s1 CHEMBL2401988 IC50 4.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695573 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(Cl)c(Cl)c2)n1 CHEMBL3695580 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(O)cc2)n1 CHEMBL3695588 IC50 4.0 nM
Fc1ccc(Nc2ccc3c(N4CCOCC4)nncc3n2)c(F)c1 CHEMBL3649494 IC50 4.0 nM
CCC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)c1 CHEMBL4069805 IC50 4.0 nM
OCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1 CHEMBL4061829 IC50 4.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1 CHEMBL3991932 IC50 4.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(F)c3)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL4778963 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccon2)cc1Nc1ncnc(NC2CCCC2)c1C#N CHEMBL383172 IC50 4.1 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3cc(F)c(F)c(F)c3)cn12 CHEMBL213374 IC50 4.1 nM
CCCNc1ncc(C(=O)Nc2cc(C(N)=O)ccc2C)s1 CHEMBL257994 IC50 4.1 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1nnc(C)c2c1cnn2-c1ccc(F)cc1 CHEMBL1082182 IC50 4.1 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 4.1 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1cc2nnc(-c3c(F)cccc3F)n2n(C)c1=O CHEMBL1945720 IC50 4.1 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2cccnc2)s1 CHEMBL2401997 Kd 4.1 nM
COc1ccc(-c2ccc(C(=O)Nc3cc(C(=O)NC4CC4)ccc3C)s2)cc1 CHEMBL2401989 IC50 4.1 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(O)cc2)s1 CHEMBL2401987 IC50 4.1 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]cnc3-c3ccccc3)cc21 CHEMBL192848 IC50 4.2 nM
CS(=O)(=O)c1nc(-c2ccccc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL212937 IC50 4.2 nM
CN(C)CCOc1nc(-c2ccccc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL211426 IC50 4.2 nM
Cc1ccc(C(=O)Nc2ccn[nH]2)cc1NC(=O)c1cnc(NC(C)C)s1 CHEMBL255288 IC50 4.2 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)C4CC4)c(F)cc3F)cc1CC2 CHEMBL4061811 IC50 4.2 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]cnc3-c3ccc(F)cc3)cc21 CHEMBL192850 IC50 4.3 nM
Cc1ccc(F)c(-c2ncoc2-c2ccc3nnc(C(C)C)n3c2)c1 CHEMBL213258 IC50 4.3 nM
Cc1cccc(-c2nc(-c3c(F)cccc3F)[nH]c2-c2ccncc2)c1 CHEMBL2385554 IC50 4.3 nM
COc1ccc(NC(=O)COc2ccc(/C=C3\N=C(c4ccccc4)N(c4cccc(OC)c4)C3=O)cc2)cc1 CHEMBL3577632 IC50 4.3 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccc(F)cc3F)cc21 CHEMBL363831 IC50 4.4 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccc(F)cc3F)cc21 CHEMBL404377 IC50 4.4 nM
Cc1ccc(NC(=O)c2ccnc(N3CCOCC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL476351 Ki 4.4 nM
Cc1cc(C(=O)Nc2cc(-c3c(-c4ccc(F)c(C)c4)nc4cccnn34)ccn2)ccn1 CHEMBL4225173 IC50 4.4 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 Kd 4.4 nM
CC(C)c1nc(-c2ccc(F)cc2)c(-c2ccc3nc(N)n(S(=O)(=O)C(C)C)c3c2)[nH]1 CHEMBL364925 IC50 4.5 nM
CCCNc1ncc(C(=O)Nc2cc(C(=O)NC)ccc2C)s1 CHEMBL257996 IC50 4.5 nM
CC(C)Cn1cnc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)nc21 CHEMBL272989 IC50 4.5 nM
Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1-c1ccc2ccncc2c1 CHEMBL497375 Ki 4.5 nM
CC(C)Cn1ncc2cc(Oc3ccc(F)cc3F)c(C(=O)NCCN(C)C)cc21 CHEMBL1088750 IC50 4.5 nM
COc1ccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4cccc(Cl)c4)cc3)N=C2c2ccccc2)cc1 CHEMBL3577644 IC50 4.5 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)N=C2c2ccccc2)c1 CHEMBL3577566 IC50 4.5 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3F)cn12 CHEMBL380030 IC50 4.6 nM
Cc1ccc(NC(=O)c2ccnc(NCC(C)C)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL478234 Ki 4.6 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1nncc2c1cnn2-c1cccc(F)c1 CHEMBL1087386 IC50 4.6 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)N=C2c2ccccc2)c1 CHEMBL3577635 IC50 4.6 nM
Cc1ccc(C(=O)Nc2ccon2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O CHEMBL2031461 pIC50 4.677 nM
CCc1nc(-c2ccc(F)cc2)c(-c2ccc3nc(N)n(S(=O)(=O)C(C)C)c3c2)[nH]1 CHEMBL191053 IC50 4.7 nM
CCN(C)c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL211919 IC50 4.7 nM
CCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)OCC)ccc3C)c2c1C CHEMBL251972 IC50 4.7 nM
Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1-c1ccc2nc(N)[nH]c(=O)c2c1 CHEMBL496312 Ki 4.7 nM
Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCN(S(C)(=O)=O)CC3)c2)[nH]1 CHEMBL1911333 IC50 4.7 nM
Cc1cccc(-c2nc(-c3ccccc3F)[nH]c2-c2ccncc2)c1 CHEMBL2385555 IC50 4.7 nM
COc1ccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccccc4Cl)cc3)N=C2c2ccccc2)cc1 CHEMBL3577643 IC50 4.7 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)C4CC4)c3)cc1CC2 CHEMBL4065681 IC50 4.7 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1CN(C)C CHEMBL106115 Kd 4.8 nM
CC(C)(C)c1nc(-c2ccc(F)cc2F)c(-c2ccc3nc(N)n(S(=O)(=O)C(C)(C)C)c3c2)[nH]1 CHEMBL190514 IC50 4.8 nM
CC(C)(C)c1nnc2ccc(Sc3ccc(F)cc3F)cn12 CHEMBL609275 IC50 4.8 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccccc2Cl)s1 CHEMBL2401983 IC50 4.8 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)C4CC4)c3)cc1CC2 CHEMBL4102537 IC50 4.8 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)cc21 CHEMBL364572 IC50 4.9 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccc[se]4)c3)cc1CC2 CHEMBL4646557 IC50 4.9 nM
COc1ccccc1C(=O)c1ccc(Nc2ccccc2N)cc1Cl CHEMBL356455 IC50 5.0 nM
OCCCCNc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cc2)ccn1 CHEMBL142753 IC50 5.0 nM
C[S+]([O-])c1ccc(-c2cc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1 CHEMBL88486 IC50 5.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccccc2)cc1 CHEMBL315100 Kd 5.0 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL194322 IC50 5.0 nM
CNc1ncc2cc(-c3cc(NC(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL424719 IC50 5.0 nM
O=C1c2ccccc2C(=O)N1CCCN(c1ccc(=O)n(-c2ccccc2Cl)n1)c1ccccc1Cl CHEMBL221547 IC50 5.0 nM
O=c1c(O)cc2c(-c3ccccc3Cl)cc(O)cc2n1-c1c(Cl)cccc1Cl CHEMBL271850 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(NC2CCN(C)CC2)nc1 CHEMBL271372 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL272888 IC50 5.0 nM
CNC(=O)c1ccc(C)c(Nc2nc(N(C)CCC#N)nc3c2cnn3-c2ccccc2)c1 CHEMBL260807 IC50 5.0 nM
Cc1ccc(NC(=O)c2cc(F)cc(N3CCOCC3)c2)cc1Nc1ncnn2cc(C(=O)NC(C)C)c(C)c12 CHEMBL261755 IC50 5.0 nM
CCCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4cc(F)cc(N5CCOCC5)c4)ccc3C)c2c1C CHEMBL442462 IC50 5.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC3CCOCC3)c2)[nH]1 CHEMBL480962 IC50 5.0 nM
CCC(C)Nc1cc(-c2[nH]c(SCC(O)CO)nc2-c2ccc(F)cc2)ccn1 CHEMBL518628 IC50 5.0 nM
Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2Cl)cc1Cl CHEMBL475817 IC50 5.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)Nc2cccc(C#N)c2)cc1 CHEMBL476507 Ki 5.0 nM
Cc1ccc(NC(=O)c2ccsc2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL476542 Ki 5.0 nM
COc1cc(F)c(-c2c(N)c(C(=O)c3ccc(F)cc3F)cc[n+]2[O-])c(F)c1 CHEMBL551189 IC50 5.0 nM
O=C(NC1CC1)c1ccc(Cl)c(Nc2nncc3c2cnn3-c2cccc(F)c2)c1 CHEMBL1088440 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(CNC(=O)CCC(=O)O)c2)n1 CHEMBL1209703 IC50 5.0 nM
CC[C@@H](C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(-c3ccccn3)n2)s1 CHEMBL1258742 IC50 5.0 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(NCCN(C)C)n2)s1 CHEMBL1258976 IC50 5.0 nM
NC(=O)Cc1cccc(-n2nc(C3CCCC3)cc2NC(=O)Nc2cccc(Cl)c2Cl)c1 CHEMBL1269947 IC50 5.0 nM
CCn1nccc1NC(=O)c1ccc(C)c(NC(=O)c2cnn(-c3ccccc3)c2N)c1 CHEMBL1290514 IC50 5.0 nM
CNc1c(C(=O)Nc2cc(C(=O)Nc3ccon3)ccc2C)cnn1-c1ccccc1 CHEMBL1289308 IC50 5.0 nM
CCNc1c(C(=O)Nc2cc(C(=O)Nc3ccon3)ccc2C)cnn1-c1ccccc1C CHEMBL1289427 IC50 5.0 nM
O=c1c(Br)c(OCc2ccc(F)cc2F)cc(CO)n1-c1c(F)cccc1F CHEMBL1797210 IC50 5.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C2(C)C CHEMBL1800909 IC50 5.0 nM
Cc1ccc(C(=O)NC2CC2)cc1Nc1ncnn2cc(C(=O)c3ccco3)c(C)c12 CHEMBL1807591 IC50 5.0 nM
Cc1ccc2c(N)noc2c1-c1ccc2c(c1)NC(=O)C21CCOCC1 CHEMBL1911341 IC50 5.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(Cl)ccc2Oc2ccnc(N3CCOCC3)n2)cc1 CHEMBL2058048 IC50 5.0 nM
O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21 CHEMBL2152944 IC50 5.0 nM
O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2cc(OC[C@@H](O)CO)ccc21 CHEMBL2152960 IC50 5.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccccc2C3=O)ccc1F)c1ccccc1 CHEMBL2177215 IC50 5.0 nM
O=C(NCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316478 IC50 5.0 nM
COCCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316475 IC50 5.0 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(C#N)cc2)s1 CHEMBL2401990 IC50 5.0 nM
COc1cc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)ccc1CO CHEMBL3695590 IC50 5.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ncccc23)cc1 CHEMBL3695571 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)n(-c2ccccc2)n1 CHEMBL1093756 IC50 5.0 nM
CSc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695581 IC50 5.0 nM
COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3695568 IC50 5.0 nM
Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695577 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(S(C)(=O)=O)cc2)n1 CHEMBL3695579 IC50 5.0 nM
COc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(OCCN6CCOCC6)c5c4)n3)c3ccccc23)cc1 CHEMBL3927937 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)c3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3936257 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(cnn5CCN5CCOCC5)c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)nc2)n1 CHEMBL3901628 IC50 5.0 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)C4CC4)ccc3F)cc1CC2 CHEMBL4087104 IC50 5.0 nM
CNc1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc23)ncn1 CHEMBL4870768 IC50 5.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 pKi 5.012 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NCCc3ccccc3)c2)s1 CHEMBL196575 IC50 5.1 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3cc(Cl)ccc3F)cn12 CHEMBL212238 IC50 5.1 nM
CC(C)Cn1cnc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccccc3)nc21 CHEMBL402188 IC50 5.1 nM
Fc1ccc(Oc2ccc3c(-c4cn[nH]c4)nncc3n2)c(F)c1 CHEMBL3649498 IC50 5.1 nM
Cc1ccc(NC(=O)c2ccnc(NC3CC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL478656 Ki 5.2 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCN(C)CC1 CHEMBL1825145 IC50 5.2 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)c4cccs4)c(F)cc3F)cc1CC2 CHEMBL4066269 IC50 5.2 nM
O=C(NO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5084172 IC50 5.2 nM
O=C(N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5085427 IC50 5.2 nM
Nc1nc(-c2ccccc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL212821 IC50 5.3 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)C4CC4)ccc3F)cc1CC2 CHEMBL4084589 IC50 5.3 nM
NCCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccccc3N)cc1CC2 CHEMBL5083671 IC50 5.3 nM
CCNc1nnc2ccc(-c3ocnc3-c3ccccc3)cn12 CHEMBL211735 IC50 5.4 nM
Cc1ccc(C(=O)Nc2ccnn2C)cc1NC(=O)c1cnc(NC(C)C)s1 CHEMBL258223 IC50 5.4 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(CO)cc2)s1 CHEMBL2401991 IC50 5.4 nM
O=C(NCCO)c1ccc2c(c1)C(=O)c1ccc(Nc3cc(NC(=O)C4CC4)c(F)cc3F)cc1CC2 CHEMBL4061369 IC50 5.4 nM
Cc1cc(-c2nc3cccnn3c2-c2ccnc(NC(=O)c3ccncc3)c2)ccc1F CHEMBL4227050 IC50 5.4 nM
Cc1cc(-c2nc3cccnn3c2-c2ccnc(NC(=O)c3cc[n+]([O-])c(C)c3)c2)ccc1F CHEMBL4224940 IC50 5.4 nM
COC(=O)[C@@H](N)CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5072899 IC50 5.4 nM
Cc1cc(-c2noc(NC(=O)Cc3ccccc3C)c2-c2ccncn2)ccc1F CHEMBL3310276 IC50 5.48 nM
CC(C)CN1CCC(c2nc(-c3ccc4nc(N)n(S(=O)(=O)C(C)C)c4c3)c(-c3ccccc3)[nH]2)CC1 CHEMBL371145 IC50 5.5 nM
CC(C)Nc1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL212849 IC50 5.5 nM
CCCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)OCC)ccc3C)c2c1C CHEMBL254660 IC50 5.5 nM
CC[C@H](C)Nc1nc2ccc(-c3c(-c4ccccc4F)n[nH]c3N)cc2s1 CHEMBL257585 IC50 5.5 nM
O=C(O)CCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5074845 IC50 5.5 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)Cc3ccccc3)c2)s1 CHEMBL197581 IC50 5.6 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3cc(F)c(F)cc3Cl)cn12 CHEMBL213598 IC50 5.6 nM
CN(C)CCNc1nc(-c2ccc(Cl)cc2Cl)c2c(n1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL213190 IC50 5.6 nM
CCOC(=O)Nc1ccc(C)c(Nc2ncnn3cc(C(=O)N[C@@H](C)CC)c(C)c23)c1 CHEMBL252373 IC50 5.6 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(n1)NC(=O)C21CCCC1 CHEMBL1825156 IC50 5.6 nM
COc1cccc(N2C(=O)/C(=C/c3ccc(OCC(=O)Nc4ccccc4Cl)cc3)N=C2c2ccccc2)c1 CHEMBL3577633 IC50 5.6 nM
Cn1cc(-c2nncc3nc(Nc4ccc(F)cc4F)ccc23)cn1 CHEMBL3649489 IC50 5.6 nM
Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCC(F)(F)CC3)c2)o1 CHEMBL3701788 IC50 5.6 nM
O=C(NCCc1c[nH]cn1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5083321 IC50 5.6 nM
Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCC(O)CC3)c2)o1 CHEMBL3701789 IC50 5.7 nM
CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccccc3N)cc1CC2 CHEMBL5087840 IC50 5.7 nM
Cn1nc(NC(=O)Cc2ccccc2)c(-c2ccncc2)c1-c1ccc(F)cc1 CHEMBL3310130 IC50 5.72 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3cc(F)ccc3F)cn12 CHEMBL379866 IC50 5.8 nM
O=C(NCCN1CC2(COC2)C1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5077679 IC50 5.9 nM
COC(=O)c1[nH]c(C(C)(C)C)cc1NC(=O)Nc1cccc(Cl)c1Cl CHEMBL18950 IC50 6.0 nM
Cc1ccc(Oc2nccc(-c3c(-c4ccc(F)cc4)ncn3C3CCNCC3)n2)c(C)c1 CHEMBL13850 IC50 6.0 nM
Nc1cc(-c2ccccc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL425422 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL385937 IC50 6.0 nM
CC(C)(C)Cn1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)cc21 CHEMBL402219 IC50 6.0 nM
O=c1ccc2c(-c3ccccc3Cl)cccc2n1-c1c(Cl)cccc1Cl CHEMBL405713 IC50 6.0 nM
CN1CCN(c2ccc(Nc3ncc(NC(=O)c4cc(NC(=O)c5ccc6c(c5)OC(F)(F)O6)ccc4Cl)cn3)cc2)CC1 CHEMBL271154 IC50 6.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1 CHEMBL272673 IC50 6.0 nM
CNC(=O)c1ccc(C)c(Nc2ncnc3c2cnn3-c2c(Cl)cccc2Cl)c1 CHEMBL260134 IC50 6.0 nM
CNC(=O)c1ccc(C)c(Nc2nc(OCCN3CCCC3)nc3c2cnn3-c2ccccc2)c1 CHEMBL429863 IC50 6.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CC3)nnc2c1 CHEMBL521734 Ki 6.0 nM
CC(C)Nc1cc(-c2[nH]c(SC[C@H](O)CO)nc2-c2ccc(F)cc2)ccn1 CHEMBL517287 IC50 6.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC(C)CO)c2)[nH]1 CHEMBL521250 IC50 6.0 nM
Cc1ccc(NC(=O)c2ccoc2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL477583 Ki 6.0 nM
Cc1ccc(NC(=O)c2ccno2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL476543 Ki 6.0 nM
CC(C)c1onc(-c2ccc(F)cc2)c1-c1ccnc(N[C@@H](C)c2ccccc2)c1 CHEMBL571357 IC50 6.0 nM
CC(c1ccc(F)cc1)N1C[C@@H](C)N(C(=O)c2cc3c(C(=O)C(=O)N(C)C)cn(C)c3cc2Cl)C[C@@H]1C CHEMBL605134 IC50 6.0 nM
CC(=O)NCC(=O)NCc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccccc2)c1 CHEMBL1209274 IC50 6.0 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(NCC(O)CO)n2)s1 CHEMBL1257244 IC50 6.0 nM
CCNC(=O)c1ccc(C)c(NC(=O)c2cnn(-c3ccccc3)c2NCC)c1 CHEMBL1289309 IC50 6.0 nM
CS(=O)(=O)CCCn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1766502 IC50 6.0 nM
CC(C)Nc1cc(-c2[nH]c([S@@+]([O-])C(C)C)nc2-c2ccc(F)cc2)ccn1 CHEMBL1773499 IC50 6.0 nM
Cc1ccc(C(=O)N[C@H](C)C(N)=O)cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O CHEMBL1795684 IC50 6.0 nM
Cc1cc(OCc2ccc(F)cc2)c(Br)c(=O)n1-c1c(Cl)cccc1Cl CHEMBL1797201 IC50 6.0 nM
CN(C)Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cccc1F CHEMBL1797212 IC50 6.0 nM
Cc1ccc(C(=O)Nc2ccccn2)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1800221 IC50 6.0 nM
CCOC(=O)Nc1ccc(C)c(Nc2ncnn3cc(C(=O)c4ccccc4)c(C)c23)c1 CHEMBL1807439 IC50 6.0 nM
CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc(C#N)c3ccccc23)s1 CHEMBL1929224 IC50 6.0 nM
CCOC(=O)CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316196 IC50 6.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(CO)nc2)n1 CHEMBL3695592 IC50 6.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cc1 CHEMBL3695583 IC50 6.0 nM
CC(=O)Nc1nccn1CCOc1ccc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(C)cc2)c2ccccc12 CHEMBL3782009 IC50 6.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc1 CHEMBL3781413 IC50 6.0 nM
CNC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781687 IC50 6.0 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(-c4ccncc4)nc3-c3ccccc3)cc21 CHEMBL437030 IC50 6.1 nM
Cc1ccc(C(=O)NC2CC2)cc1Oc1cc(=O)n(C)c2c1cnn2-c1cc(F)ccc1F CHEMBL561468 IC50 6.1 nM
Cn1c(=O)c(Cc2ccc(F)cc2F)cc2cnnc(-c3ccc(F)cc3F)c21 CHEMBL1253813 IC50 6.1 nM
NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccccc3N)cc1CC2 CHEMBL5083496 IC50 6.1 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@H](Oc3ccc4nnc(C(C)C)n4c3)CC2)cc1 CHEMBL5204479 IC50 6.1 nM
CC(C)c1nnc2ccc(-c3[nH]cnc3-c3cc(F)ccc3F)cn12 CHEMBL214152 IC50 6.2 nM
CS(=O)(=O)N1CCCC(NC(=O)[C@H](CCC2CCCCC2)NC(=O)c2ccc(CNC(=O)c3cnc4ccccn34)cc2)C1 CHEMBL4591082 IC50 6.2 nM
NC(=O)CCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5078332 IC50 6.2 nM
Cc1ccc(NC(=O)c2ccnc(NCC3CC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL478031 Ki 6.3 nM
Cc1ccc(C(=O)NC2CC2)cc1Oc1nnc(C)c2c1cnn2-c1ccc(F)cc1F CHEMBL1081037 IC50 6.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2nnc(-c3cc(F)ccc3Cl)n2n(C)c1=O CHEMBL1945718 IC50 6.3 nM
O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(/C=N/NC(=O)c4ccccc4)c3)cc1CC2 CHEMBL4640746 IC50 6.3 nM
CCNC(=O)[C@H](CCC1CCCCC1)NC(=O)c1ccc(CNC(=O)c2cnn(-c3ccccc3)c2N)cc1 CHEMBL4756586 Kd 6.3 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)N[C@@H](C)C(C)(C)C)cn1 CHEMBL1784177 pKi 6.31 nM
Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(NC(C)(C)c2ccccc2)c1=O CHEMBL4777646 pIC50 6.31 nM
CC(C)Nc1nc2ccc(-c3ocnc3-c3ccccc3F)cc2s1 CHEMBL257341 IC50 6.4 nM
CC(C)(C)Cn1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)nc21 CHEMBL403294 IC50 6.4 nM
O=C(NCCc1cccs1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5086200 IC50 6.4 nM
Fc1ccc(-c2c(-c3ccncc3)[nH]c3cccnc23)cc1 CHEMBL344955 IC50 6.5 nM
CC[C@@H](C)Nc1nc2ccc(-c3ocnc3-c3ccccc3F)cc2s1 CHEMBL255268 IC50 6.5 nM
Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cc(OCCC[C@H](N)C(=O)OC2CCCC2)cc1F CHEMBL3220550 IC50 6.5 nM
COc1cccc(NC(=O)COc2ccc(/C=C3\N=C(c4ccccc4)N(c4cccc(OC)c4)C3=O)cc2)c1 CHEMBL3577631 IC50 6.5 nM
Cc1noc(C)c1-c1nncc2nc(Oc3ccc(F)cc3F)ccc12 CHEMBL3649501 IC50 6.5 nM
O=C(Nc1cc(Nc2ccc3c(c2)OCc2ccc(C(=O)NC(CO)CO)cc2C3=O)c(F)cc1F)c1ccsc1 CHEMBL4077106 IC50 6.5 nM
Oc1ccccc1Oc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL273432 IC50 6.6 nM
Cc1cc(-c2ncoc2-c2ccc3nnc(C(C)C)n3c2)ccc1F CHEMBL215858 IC50 6.6 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NCc3ccccc3)c2)s1 CHEMBL196576 IC50 6.7 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(-c4c(Cl)cccc4Cl)nc3-c3ccc(F)cc3)cc21 CHEMBL402399 IC50 6.7 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1-c1ccc(-c2csc(N)n2)cc1 CHEMBL526452 Ki 6.7 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)cc(-c3cccs3)oc2c1 CHEMBL496528 Ki 6.7 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCS(=O)(=O)CC1 CHEMBL1825150 IC50 6.7 nM
CC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3972318 IC50 6.7 nM
O=C(NCC(O)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)C4CC4)c3)cc1CC2 CHEMBL4066327 IC50 6.7 nM
FC(F)(F)c1cccc(-c2n[nH]cc2-c2ccnc3ccccc23)c1 CHEMBL129678 IC50 6.8 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCC3)c2)cc1-c1ccc2nc(N)[nH]c(=O)c2c1 CHEMBL521548 Ki 6.8 nM
O=C(Cc1ccccc1Cl)Nc1onc(-c2ccc(F)cc2)c1-c1ccncn1 CHEMBL3310141 IC50 6.88 nM
COC(=O)[C@H](CCSC)NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5089367 IC50 6.9 nM
COC(=O)c1cc(-c2ccc(F)cc2F)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL94547 pIC50 6.998 nM
COC(=O)c1cc(-c2ccccc2F)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)NC2 CHEMBL94495 pIC50 6.998 nM
Cc1ccccc1C(=O)c1ccc(Nc2ccccc2)cc1Cl CHEMBL155567 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCN3CCCC3)ncc2c1 CHEMBL214556 IC50 7.0 nM
CC(C)(C)Cn1cnc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccc(F)cc3)nc21 CHEMBL411291 IC50 7.0 nM
Cc1ccc(C(N)=O)cc1Nc1ncnc2c1cnn2-c1ccccc1 CHEMBL439267 IC50 7.0 nM
CCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)c4cccc(-n5ccnc5)c4)ccc3C)c2c1C CHEMBL262867 IC50 7.0 nM
COc1ccc(NC(=O)c2ccc(-c3cc(C(=O)NC4CC4)ccc3C)cc2)cc1 CHEMBL478819 Ki 7.0 nM
CCNC(=O)NCc1ccccc1-c1cc(-c2cnc(NC(C)C)s2)nc(NCCN(C)C)n1 CHEMBL1230171 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2ccc(CC(=O)N3CCS(=O)(=O)CC3)cc2)n1 CHEMBL1271268 IC50 7.0 nM
Cc1ccc(C(=O)Nc2ccnn2C)cc1NC(=O)c1cnn(-c2ccccc2)c1N CHEMBL1290405 IC50 7.0 nM
CCCCn1ncc(C(=O)Nc2cc(C(=O)Nc3ccnn3C)ccc2C)c1N CHEMBL1287825 IC50 7.0 nM
O=c1c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc2n1C[C@H](O)CO CHEMBL1766505 IC50 7.0 nM
Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cc(OCCO)cc1F CHEMBL1797208 IC50 7.0 nM
Cc1ccc(C(N)=O)cc1Nc1ncnn2cc(C(=O)c3ccccc3)c(C)c12 CHEMBL1807442 IC50 7.0 nM
COC(=O)[C@H](CC(C)C)NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316199 IC50 7.0 nM
O=C(Nc1cc(Nc2ccc3c(c2)CCc2ccc(OC[C@H](O)CO)cc2C3=O)ccc1F)c1cccs1 CHEMBL2316493 IC50 7.0 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnc(-c2ccccc2Cl)s1 CHEMBL2401978 IC50 7.0 nM
CNS(=O)(=O)Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695574 IC50 7.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cn1 CHEMBL3695572 IC50 7.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c(Cl)c2Cl)cc1 CHEMBL3695586 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(CO)cc2)n1 CHEMBL3695589 IC50 7.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(C)nc34)c3ccccc23)cc1 CHEMBL1214135 IC50 7.0 nM
NC(=O)[C@H](CCC1CCCCC1)NC(=O)c1ccc(CNC(=O)c2cnn(-c3ccccc3)c2N)cc1 CHEMBL3939964 IC50 7.0 nM
COc1ccc(-n2nc(C3CCOC3)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)cc1 CHEMBL3921479 IC50 7.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)C)nn4-c4cccc(OCCN5CCOCC5)c4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3915395 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2ccc(=O)n(CCO)c2)n1 CHEMBL3944099 IC50 7.0 nM
Oc1cccc(-c2nc(-c3ccc(F)cc3)c(-c3ccnc4[nH]c(-c5ccccc5)cc34)[nH]2)c1 CHEMBL4097627 IC50 7.0 nM
Cc1nc(-c2ccc(F)c(C)c2)c(-c2ccnc(NC(=O)C3CC3)c2)[nH]1 CHEMBL4457174 IC50 7.0 nM
CCNC(=O)NCc1ccccc1-c1cc(-c2cnc(NC(C)C)s2)nc(NCCNC)n1 CHEMBL4593539 IC50 7.0 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1 CHEMBL363648 IC50 7.1 nM
CC(C)Nc1nc2ccc(-c3[nH]cnc3-c3ccccc3)cc2s1 CHEMBL256925 IC50 7.1 nM
Cc1nc(-c2ccc(F)cc2)c(-c2ccc3nc(N)n(S(=O)(=O)C(C)C)c3c2)[nH]1 CHEMBL271059 IC50 7.1 nM
CCNC(=O)c1cn2ncnc(Nc3cc(C(=O)Nc4ccon4)ccc3C)c2c1C CHEMBL1255004 IC50 7.1 nM
Cc1noc(C)c1-c1nncc2nc(Nc3ccc(F)cc3F)ccc12 CHEMBL3649493 IC50 7.1 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3c(F)cc(F)cc3F)cn12 CHEMBL210060 IC50 7.2 nM
CC(C)(C)Cn1cnc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccc(F)cc3)nc21 CHEMBL404118 IC50 7.2 nM
Fc1ccc(Sc2ccc3nnc(-c4ccc(F)cc4F)n3c2)c(F)c1 CHEMBL592978 IC50 7.2 nM
CCc1ccc(Oc2nccc(-c3c(-c4ccc(F)cc4)ncn3C3CCNCC3)n2)cc1 CHEMBL428877 IC50 7.4 nM
Cc1ncc(C(=O)NC2CC2)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1825155 IC50 7.4 nM
Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCCC3)c2)[nH]1 CHEMBL1911193 IC50 7.4 nM
Nc1ccc(Nc2cc(-c3[nH]cnc3-c3ccc(F)cc3)ccn2)cc1 CHEMBL5271950 IC50 7.5 nM
CCNc1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL213451 IC50 7.6 nM
Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCOCC3)c2)[nH]1 CHEMBL1911194 IC50 7.6 nM
CCOC(=O)Nc1ccc(C)c(Nc2ncnn3cc(C(=O)NC(C)C)c(C)c23)c1 CHEMBL252168 IC50 7.7 nM
Cc1ccc(C(=O)NC2CC2)cc1Oc1nnc(C)c2c1cnn2-c1ccc(F)cc1 CHEMBL1082183 IC50 7.7 nM
Cc1ccc(-c2ccc(C(=O)Nc3cc(C(=O)NC4CC4)ccc3C)s2)cn1 CHEMBL2402001 IC50 7.7 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2cncc(F)c2)s1 CHEMBL2401999 IC50 7.7 nM
Fc1cc(F)c(-c2ncoc2-c2ccc3nnc(C4CC4)n3c2)cc1F CHEMBL212341 IC50 7.8 nM
Cc1ccc(C(=O)NC2CC2)cc1Oc1cc(=O)n(C)c2c1cnn2-c1ccc(F)cc1F CHEMBL563284 IC50 7.8 nM
COC(=O)c1ccc(C)c(-c2nnc3ccc(Sc4ccc(F)cc4F)cn23)c1 CHEMBL595338 IC50 7.8 nM
O=C(NCCc1ccc(O)cc1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5077220 IC50 7.8 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)C3CCCCC3)c2)s1 CHEMBL198383 IC50 7.9 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cn1 CHEMBL1088752 pKi 7.943 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC2CC2)cn1 CHEMBL1784172 pKi 7.943 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)C)cn1 CHEMBL1784173 pKi 7.943 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)N[C@H](C)C(C)C)cn1 CHEMBL1784174 pKi 7.943 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)N[C@@H](C)C(C)C)cn1 CHEMBL1784175 pKi 7.943 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccc(F)c(Br)c3)cn12 CHEMBL439540 IC50 8.0 nM
O=C(NCCCN(c1ccc(=O)n(-c2ccccc2Cl)n1)c1ccccc1Cl)C1CCNCC1 CHEMBL221648 IC50 8.0 nM
CONC(=O)c1ccc(C)c(Nc2nc(N[C@H]3CCNC3)nc(N(C)CC(C)(C)C)n2)c1 CHEMBL225418 IC50 8.0 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NCCN4CCOCC4)c(C)c23)c1 CHEMBL252944 IC50 8.0 nM
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NC4CCCC4)c(C)c23)c1 CHEMBL252337 IC50 8.0 nM
COc1ccccc1C(=O)Nc1ccc(C)c(C(=O)Nc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2)c1 CHEMBL409734 IC50 8.0 nM
CCn1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4c3cnn4-c3ccccc3)c2)n1 CHEMBL258974 IC50 8.0 nM
CNC(=O)c1ccc(C)c(Nc2nc(N3CCCN(C)CC3)nc3c2cnn3-c2ccccc2)c1 CHEMBL265710 IC50 8.0 nM
Cc1cc(O)ccc1-c1c(N)c(C(=O)c2ccc(F)cc2F)cc[n+]1[O-] CHEMBL552164 IC50 8.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2c(C)nn(-c3c(F)cccc3F)c2n(C)c1=O CHEMBL1091927 Ki 8.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc([N+](=O)[O-])c2)n1 CHEMBL578172 Kd 8.0 nM
CC[C@H](C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(-c3ccccn3)n2)s1 CHEMBL1258741 IC50 8.0 nM
CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(NCCO)n2)s1 CHEMBL1258977 IC50 8.0 nM
CCNC(=O)c1ccc(C)c(NC(=O)c2cnn(-c3ccccc3)c2N)c1 CHEMBL1290289 IC50 8.0 nM
Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cc(N(C)C)cc1F CHEMBL1797206 IC50 8.0 nM
O=c1c(Cl)c(OCc2ccc(F)cc2F)cc(CO)n1-c1c(F)cccc1F CHEMBL1797211 IC50 8.0 nM
CN(C)Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F CHEMBL1797213 IC50 8.0 nM
O=C(NC1CC1)c1cccc(-c2cc3c(cc2Cl)C2(CCCC2)C(=O)N3)c1 CHEMBL1800915 IC50 8.0 nM
Cc1cccc(C(=O)c2cn3ncnc(Nc4cc(C(=O)NC5CC5)ccc4C)c3c2C)n1 CHEMBL1807463 IC50 8.0 nM
Nc1ccccc1Nc1ccc2c(c1)CCc1ccc(OC[C@@H](O)CO)cc1C2=O CHEMBL2152938 IC50 8.0 nM
O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OCCCO)cc21 CHEMBL2152941 IC50 8.0 nM
O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@@H](O)CO)cc21 CHEMBL2152946 IC50 8.0 nM
O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OCCCN3CCOCC3)cc21 CHEMBL2152950 IC50 8.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccnc4[nH]c(-c5ccccc5)cc34)[nH]2)cc1 CHEMBL2179117 IC50 8.0 nM
CCCOC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316203 IC50 8.0 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(F)cc2)s1 CHEMBL2401984 IC50 8.0 nM
O=C1c2cc(OCCCO)ccc2COc2cc(Nc3ccc(F)cc3F)ccc21 CHEMBL3086680 IC50 8.0 nM
CC(=O)Nc1cnccc1CCOc1ccc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(C)cc2)c2ccccc12 CHEMBL3780488 IC50 8.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)CS(C)(=O)=O)c3)c3ccccc23)cc1 CHEMBL3780832 IC50 8.0 nM
Cc1nnc(-c2cc(F)c(C)c(-c3ccc4c(c3)NC(=O)C43CCOCC3)c2)[nH]1 CHEMBL3701786 IC50 8.0 nM
Cc1nnc(-c2cc(F)c(C)c(-c3ccc4c(c3)NC(=O)C43CCC(C)(O)CC3)c2)[nH]1 CHEMBL3701787 IC50 8.0 nM
CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2cccc(OCCN3CCOCC3)c2)n1 CHEMBL3893816 IC50 8.0 nM
CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2ccc(=O)n(CCO)c2)n1 CHEMBL3912657 IC50 8.0 nM
O=C(O)CC[C@H](NC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2)C(=O)O CHEMBL5092751 IC50 8.0 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)CCc3ccccc3)c2)s1 CHEMBL194201 IC50 8.1 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NCCCc3ccccc3)c2)s1 CHEMBL381864 IC50 8.1 nM
Cc1ccc(C(=O)Nc2ccno2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O CHEMBL2031462 pIC50 8.128 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccc(Cl)cc3Cl)cn12 CHEMBL211362 IC50 8.3 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnnc(-c3ccc(F)cc3F)c21 CHEMBL1253894 IC50 8.4 nM
Cc1cccc(-c2nc(-c3ccc(O)cc3)[nH]c2-c2ccncc2)c1 CHEMBL2385556 IC50 8.4 nM
CN(C)CCNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccccc3N)cc1CC2 CHEMBL5087468 IC50 8.4 nM
Cc1ccc(C)c(CC(=O)Nc2onc(-c3ccc(F)cc3)c2-c2ccncn2)c1 CHEMBL3310143 IC50 8.43 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCN(Cc3ccccc3)CC2)n1 CHEMBL329049 IC50 8.5 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(-c4c(Cl)cccc4C(F)(F)F)nc3-c3ccccc3)cc21 CHEMBL270002 IC50 8.5 nM
Cc1ccc(C(=O)NC2CC2)cc1Oc1cc(=O)n(C)c2c1cnn2-c1cccc(F)c1 CHEMBL564121 IC50 8.5 nM
O=C(NC1CC1)c1ccc(Cl)c(Nc2nncc3c2cnn3-c2ccc(F)cc2)c1 CHEMBL1088441 IC50 8.5 nM
CNC(=O)c1ccc(F)c(-n2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)c1 CHEMBL1802636 IC50 8.5 nM
Cc1ccc(C(N)=O)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1800917 IC50 8.5 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2ccc(CN(C)C)cc2)s1 CHEMBL2401992 IC50 8.6 nM
CN(C)CCNC(=O)c1ccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)cc1 CHEMBL399167 IC50 8.7 nM
CCC(=O)Nc1cc(-c2sc(CC)nc2-c2cccc(C)c2)ccn1 CHEMBL199160 IC50 8.8 nM
CC(C)Cc1nnc2ccc(-c3ocnc3-c3ccc(F)cc3)cn12 CHEMBL212655 IC50 8.8 nM
CC(C)(C)c1nnc2ccc(-c3ocnc3-c3cc(F)ccc3F)cn12 CHEMBL212708 IC50 8.8 nM
Cc1nc(-c2ccc(F)cc2F)c(-c2ccc3nc(N)n(S(=O)(=O)C(C)C)c3c2)[nH]1 CHEMBL270842 IC50 8.8 nM
Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(-c2cccc(Cl)c2)s1 CHEMBL2401982 IC50 8.9 nM
Cc1ccc(NC(=O)c2ccoc2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O CHEMBL2031238 pIC50 8.913 nM
COC(=O)c1cc(Cl)c(N2C(=O)NCc3nc(Sc4ccc(F)cc4)ccc32)c(Cl)c1 CHEMBL129628 IC50 9.0 nM
CCn1c(=O)n(CC)c2cc(-c3c[nH]nc3-c3cccc(C)c3)ccc21 CHEMBL355703 IC50 9.0 nM
CS(=O)(=O)c1ccc(-c2cc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1 CHEMBL316275 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCN3CCCCC3)ncc2c1 CHEMBL384942 IC50 9.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4OC4CCN(C)CC4)ccc3C)ccc2n1 CHEMBL386661 IC50 9.0 nM
O=C1c2ccccc2C(=O)N1CCCN(c1ccc(=O)n(-c2ccccc2Cl)n1)c1ccc(F)cc1Cl CHEMBL221595 IC50 9.0 nM
COc1cc(-c2ccccc2Cl)c2c(c1)N(c1c(Cl)cccc1Cl)C(=O)C(O)C2 CHEMBL270812 IC50 9.0 nM
CNC(=O)c1ccc(C)c(Nc2ncnc3c2cnn3-c2ccc(F)cc2)c1 CHEMBL259212 IC50 9.0 nM
CNC(=O)c1ccc(C)c(Nc2ncnc3c2cnn3-c2ccccc2F)c1 CHEMBL409329 IC50 9.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(N[C@H](C)C3CCCCC3)c2)[nH]1 CHEMBL481913 IC50 9.0 nM
O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Nc3ccc(N4CCC(N5CCCCC5)CC4)cc3)n2)c1 CHEMBL453438 IC50 9.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL478649 Ki 9.0 nM
Nc1c(C(=O)c2ccc(F)cc2F)cc[n+]([O-])c1-c1c(Cl)cccc1Cl CHEMBL559783 IC50 9.0 nM
C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@@H](C)CN1C(=O)c1cc2c(C(=O)C(=O)N(C)C)cn(C)c2cc1Cl CHEMBL591217 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2cccc(CC(N)=O)c2)n1 CHEMBL1271376 IC50 9.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC(=O)Cc3ccc(F)cc3)c2)[nH]1 CHEMBL1271554 IC50 9.0 nM
O=c1c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc2n1C1CC1 CHEMBL1766499 IC50 9.0 nM
O=c1c(Br)c(OCc2ccc(F)cc2F)cc(CN2CCOCC2)n1-c1c(F)cccc1F CHEMBL1797214 IC50 9.0 nM
Cc1ccc(-c2ncn[nH]2)cc1-c1ccc2c(c1)NC(=O)C21CCCC1 CHEMBL1911197 IC50 9.0 nM
CCOCCOc1cc(-c2ccccc2Cl)c2cc[n+]([O-])c(-c3c(Cl)cccc3Cl)c2n1 CHEMBL1916531 IC50 9.0 nM
Cc1ccc(NC(=O)c2ccc(C#N)cc2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O CHEMBL2031227 IC50 9.0 nM
O=C(Nc1cccc(Nc2ccc3c(c2)CCc2ccccc2C3=O)c1)c1ccoc1 CHEMBL2182071 IC50 9.0 nM
O=C(NC(CO)CO)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL2316480 IC50 9.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)Cc4ccccc4)c3)c3ccccc23)cc1 CHEMBL3781473 IC50 9.0 nM
Nc1c(C(=O)NCc2ncc(C(=O)NC3CC3)s2)cnn1-c1ccccc1 CHEMBL4444997 IC50 9.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC2CC2)cn1 CHEMBL1232887 Ki 9.0 nM
Cc1cccc(-c2nc(-c3ccc(S(C)(=O)=O)cc3)sc2-c2ccnc(NCCc3ccccc3)c2)c1 CHEMBL382103 IC50 9.1 nM
Fc1cc(F)c(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)cc1F CHEMBL377757 IC50 9.1 nM
CCN(C)c1nnc2ccc(-c3ocnc3-c3ccccc3)cn12 CHEMBL377841 IC50 9.2 nM
O=C(O)CNC(=O)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)cc3F)cc1CC2 CHEMBL5086246 IC50 9.3 nM
COc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(C)cc2)c2ccccc2c1 CHEMBL107161 Kd 9.4 nM
Cc1cc(-c2nc3cccnn3c2-c2ccnc(NC(=O)c3ccccc3)c2)ccc1F CHEMBL4228109 IC50 9.4 nM
Cc1ccc(C(=O)N(C)C)cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O CHEMBL1802633 IC50 9.5 nM
CCNc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCN(C)CC2)n1 CHEMBL420081 IC50 9.6 nM
CC(C)c1nnc2ccc(-c3ocnc3-c3ccccc3)cn12 CHEMBL379929 IC50 9.6 nM
Fc1ccc(F)c(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)c1 CHEMBL214310 IC50 9.7 nM
CC(C)Cn1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)cc21 CHEMBL444636 IC50 9.9 nM