C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F CHEMBL4546504 IC50 0.032 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 CHEMBL2392833 Kd 0.14 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCCC3=O)cc2)ncc1Cl CHEMBL3220502 IC50 0.24 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)NCCCNC(=O)c1ccc(-c2n[nH]c3ccccc23)cc1 CHEMBL1822313 IC50 0.7 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CCC(O)CC3)CC2)n1 CHEMBL2425628 Kd 0.75 nM
COc1ccc(CC(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)cc1 CHEMBL3393600 IC50 0.8 nM
COc1cc(S(C)(=O)=O)c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1 CHEMBL378627 Ki 1.0 nM
N#Cc1ccc2c(ccc(=O)n2CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c1 CHEMBL1822151 IC50 1.0 nM
N#Cc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 CHEMBL1822152 IC50 1.0 nM
Cn1cnc(-c2c(Br)csc2NC(=O)CN2C(=O)CCc3ncccc32)n1 CHEMBL1822305 IC50 1.0 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl CHEMBL3220493 IC50 1.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccn(Cc2ccccc2)c(=O)c1 CHEMBL3679421 IC50 1.0 nM
Cc1cc(NC(=O)c2cccc(NC(=O)/C=C/CN(C)C)c2)ccc1Nc1nccc(-c2cccnc2)n1 CHEMBL2216824 IC50 1.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@](C)(O)C3)n2)CC1 CHEMBL4856984 IC50 1.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCCC[C@H](O)C3)n2)CC1 CHEMBL4849353 IC50 1.0 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)cc2)c1 CHEMBL3393608 IC50 1.3 nM
CC(C)C[C@@H](NC(=O)CNC(=O)CNC(=O)CCCNC(=O)c1ccc(-c2n[nH]c3ccccc23)cc1)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(N)=O)[C@H](C)O)[C@H](C)O CHEMBL1822314 Ki 1.5 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4cccnc4)n3)cc2)c1 CHEMBL3393607 IC50 1.5 nM
CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N CHEMBL210618 pKi 1.995 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 IC50 2.0 nM
O=C(Cn1c(=O)ccc2cc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822146 IC50 2.0 nM
O=C(Cn1c(=O)ccc2cc(OC(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822149 IC50 2.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1cscn1 CHEMBL1822309 IC50 2.0 nM
N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](CO)CC3)n2)CC1 CHEMBL3674700 IC50 2.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@@H](O)C3)n2)CC1 CHEMBL4853125 IC50 2.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CC[C@@H](C)[C@H](O)C3)n2)CC1 CHEMBL4878370 IC50 2.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](OCC(F)(F)F)CC2)nc1N[C@@H]1CCC[C@H](O)C1 CHEMBL4864618 IC50 2.0 nM
CS(=O)(=O)C[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 CHEMBL3674715 IC50 2.4 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 2.512 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1C#N CHEMBL210963 Ki 3.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1Cl CHEMBL210928 Ki 3.0 nM
CN(C)c1c(-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)cnn1Cc1ccccc1 CHEMBL1094014 Ki 3.0 nM
O=C(Cn1c(=O)ccn2nc(C(F)(F)F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822144 IC50 3.0 nM
O=C(Cn1c(=O)ccc2cc(F)c(F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822145 IC50 3.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392825 IC50 3.0 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL3220495 IC50 3.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL3674690 IC50 3.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@H](O)C3)n2)CC1 CHEMBL4847078 IC50 3.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1N[C@@H]1CCC[C@H](O)C1 CHEMBL4853525 IC50 3.0 nM
[2H]C([2H])([2H])O[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@H](O)C3)n2)CC1 CHEMBL4862107 IC50 3.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](OC(F)F)CC2)nc1N[C@@H]1CCC[C@H](O)C1 CHEMBL4845965 IC50 3.0 nM
CCOc1nc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc(N)c1C#N CHEMBL2004355 pKi 3.162 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(NS(=O)(=O)c2ccc(C(=O)O)cc2)cc1 CHEMBL260429 IC50 3.3 nM
CN(C)S(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL3674691 IC50 3.6 nM
CC(C)(C)OC(=O)NCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](NS(C)(=O)=O)CC3)n2)CC1 CHEMBL3674695 IC50 3.6 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)CC3)n2)CC1 CHEMBL3674724 IC50 3.6 nM
CN(C)CCN([C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1)S(C)(=O)=O CHEMBL3674699 IC50 3.7 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1Cl CHEMBL377383 Ki 3.8 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 3.981 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL424872 pKi 3.981 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 3.981 nM
CCOc1nc(C(=O)NCc2ccc(-c3ccc(C(=O)O)cc3)nc2)cc(N)c1C#N CHEMBL211584 IC50 4.0 nM
O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682014 IC50 4.0 nM
O=C(Cn1c(=O)ccc2cnccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822140 IC50 4.0 nM
O=C(Cn1c(=O)ccc2cnc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822141 IC50 4.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1ncco1 CHEMBL1822307 IC50 4.0 nM
COc1ccc(Oc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 CHEMBL1923217 IC50 4.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 CHEMBL2425634 IC50 4.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ncc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 CHEMBL2425635 IC50 4.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2ncccc2c1=O)c1ccn(Cc2ccccc2)c(=O)c1 CHEMBL3679429 IC50 4.0 nM
COC(=O)c1c(CNC(=O)c2ccc(S(C)(=O)=O)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679528 IC50 4.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3cnco3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679529 IC50 4.0 nM
COC(=O)c1c(CNC(=O)c2ccc(N3CCOCC3)nc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL3679588 IC50 4.0 nM
N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](CN4CC[C@@H](O)C4)CC3)n2)CC1 CHEMBL3674698 IC50 4.2 nM
N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 CHEMBL3674727 IC50 4.4 nM
COC1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(OCCCS(C)(=O)=O)cccc54)n3)CC2)CC1 CHEMBL2425630 IC50 4.7 nM
N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(NC3CCCCC3)n2)CC1 CHEMBL3674711 IC50 4.9 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1ncn[nH]1 CHEMBL1822139 IC50 5.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 CHEMBL2392827 IC50 5.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3nnc[nH]3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679530 IC50 5.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(NC34CC(C3)C4)n2)CC1 CHEMBL4875131 IC50 5.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 5.012 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 5.012 nM
CS(=O)(=O)C1CCN(c2cccc3c2cnn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 CHEMBL2392832 IC50 5.8 nM
O=C(Cn1c(=O)ccc2ccc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822147 IC50 6.0 nM
COC(=O)c1c(CNC(=O)c2ccc(N3CCOCC3)nc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679531 IC50 6.0 nM
COC(=O)c1ccc(C(=O)NCc2c(C(=O)OC)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL3679552 IC50 6.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1Nc1ccccc1 CHEMBL4878046 IC50 6.0 nM
CCNC(=O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL3674693 IC50 6.1 nM
CS(=O)(=O)CCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2390974 IC50 6.2 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(=O)NC2CC2)n(C)n1 CHEMBL258618 IC50 6.4 nM
CC(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392834 IC50 6.6 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cn(C(=O)NC)c(C)n1 CHEMBL259484 IC50 6.8 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCC5CCS(=O)(=O)C5)cccc43)n2)CC1 CHEMBL2392831 IC50 6.8 nM
CCOC(=O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392837 IC50 6.8 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncco1 CHEMBL1822153 IC50 7.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1nccs1 CHEMBL1822308 IC50 7.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C4CCCC4)c3n2)CC1 CHEMBL3577877 IC50 7.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccnc(N2CCOCC2)c1 CHEMBL3679422 IC50 7.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2ncccc2c1=O)c1ccc(N2CCC(CO)CC2)nc1 CHEMBL3679432 IC50 7.0 nM
COC(=O)c1c(CNC(=O)c2ccc3scnc3c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679532 IC50 7.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3ncc[nH]3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679533 IC50 7.0 nM
COC(=O)c1c(CNC(=O)c2ccc(OC)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679553 IC50 7.0 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(N)=O)n(C)n1 CHEMBL437107 IC50 7.3 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(S(C)(=O)=O)n(CC(C)=O)n1 CHEMBL260064 IC50 7.6 nM
CCOc1nc(C(=O)NCc2cccnc2)cc(N)c1C#N CHEMBL209534 pKi 7.943 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 7.943 nM
CCOc1nc(C(=O)NCc2ccncc2)cc(N)c1C#N CHEMBL1984206 pKi 7.943 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 7.943 nM
O=C(Cn1c(=O)ccc2nc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822142 IC50 8.0 nM
O=C(Cn1c(=O)ccn2nccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822143 IC50 8.0 nM
COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(Cl)cn2)cc1 CHEMBL1923187 IC50 8.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCC(O)CC4)CC3)n2)CC1 CHEMBL2392838 IC50 8.0 nM
COC(=O)c1c(CNC(=O)c2ccc(S(N)(=O)=O)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679534 IC50 8.0 nM
COC(=O)c1c(CNC(=O)c2cnc(N3CCOCC3)s2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679535 IC50 8.0 nM
COC(=O)c1c(CNC(=O)c2cccc(OC)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679554 IC50 8.0 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(S(C)(=O)=O)n(CC(N)=O)n1 CHEMBL260065 IC50 8.2 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@@](C)(O)CC3)n2)CC1 CHEMBL2392835 IC50 8.5 nM
CCNC(=O)n1ccc(Cn2c(C(=O)CC)c(-c3ccccc3)c3cc(Cl)ccc3c2=O)n1 CHEMBL258705 IC50 8.6 nM
NC(=O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL242237 IC50 9.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)CC1 CHEMBL482559 Ki 9.0 nM
O[C@H]1CC[C@H](Nc2nccc(-c3c[nH]nc3C3CCCOC3)n2)CC1 CHEMBL1089007 Ki 9.0 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 CHEMBL1682015 IC50 9.0 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822138 IC50 9.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCOCC2)nc1 CHEMBL3679423 IC50 9.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(NC(=O)CCC(=O)O)cc1 CHEMBL261014 IC50 9.2 nM
CCN1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCN(C(=O)CC#N)CC6)cccc54)n3)CC2)CC1 CHEMBL3674728 IC50 9.2 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(=O)NC)n(C)n1 CHEMBL259720 IC50 9.4 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(C(=O)O)cc1 CHEMBL259554 IC50 9.6 nM
CCO[C@@H]1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCC(S(C)(=O)=O)CC6)cccc54)n3)CC2)C1 CHEMBL3674704 IC50 9.6 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CC[C@@H](O)C3)CC2)n1 CHEMBL2425629 IC50 9.7 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(S(C)(=O)=O)n(CCC(C)(C)O)n1 CHEMBL261413 IC50 10.0 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(S(C)(=O)=O)n(CC(F)F)n1 CHEMBL411083 IC50 10.0 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(=O)NC2CC2)n(CC(F)F)n1 CHEMBL409350 IC50 10.0 nM
Cn1cc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cn1 CHEMBL1761564 IC50 10.0 nM
Cc1ncn(-c2ccc(Nc3ncc4cccc(-c5nccs5)c4n3)cc2)n1 CHEMBL1761569 IC50 10.0 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1nccs1 CHEMBL1822306 IC50 10.0 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 10.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 EC50 10.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CO)CC5)cccc43)n2)CC1 CHEMBL2392828 IC50 10.0 nM
COC(=O)c1c(CNC(=O)c2ccc(C(N)=O)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679536 IC50 10.0 nM
COC(=O)c1c(CNC(=O)c2ccc(Cl)nc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL3679589 IC50 10.0 nM
NC(=O)c1cnc(NC23CC(C2)C3)nc1N[C@@H]1CCC[C@H](O)C1 CHEMBL4877389 IC50 10.0 nM
NC(=O)c1cnc(N[C@@H]2CCC[C@H](O)C2)nc1NC12CC(C1)C2 CHEMBL4877655 IC50 10.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5432340 IC50 10.0 nM
CC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](N(C)S(C)(=O)=O)CC3)n2)CC1 CHEMBL3674686 IC50 10.3 nM
CC(=O)OCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](NS(C)(=O)=O)CC3)n2)CC1 CHEMBL3674689 IC50 10.4 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(N)=O)n(CC)n1 CHEMBL258845 IC50 11.0 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(=O)N(C)C)n(C)n1 CHEMBL258631 IC50 11.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 11.0 nM
N#Cc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1ncn[nH]1 CHEMBL1682018 IC50 11.0 nM
O=C(Cn1c(=O)ccc2ccc(OC(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822150 IC50 11.0 nM
CC(C)(C)OC(=O)N1CC2CC1CN2c1ccc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679482 IC50 11.0 nM
CNC(=O)c1ccc(C(=O)NCc2c(C(=O)OC)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL3679537 IC50 11.0 nM
C[C@@H]1CC[C@@H](Nc2nc(NC(C)(C)C)ncc2C(N)=O)C[C@H]1O CHEMBL4847106 IC50 11.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1NC12CC(C1)C2 CHEMBL4862452 IC50 11.0 nM
C[C@@H]1CC[C@@H](Nc2nc(NC3(C)CC3)ncc2C(N)=O)C[C@H]1O CHEMBL4872066 IC50 11.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@](C)(O)CC3)n2)CC1 CHEMBL3674692 IC50 11.7 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCn5cnnc5C4)CC3)n2)CC1 CHEMBL2392840 IC50 11.7 nM
CCOc1nc(C(=O)NCc2ccccc2S(N)(=O)=O)cc(N)c1C#N CHEMBL377408 IC50 12.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(NS(C)(=O)=O)cc1 CHEMBL261841 IC50 12.0 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4ccccc4C(N)=O)c4cc[nH]c4n3)c(C)c2)C1 CHEMBL513897 IC50 12.0 nM
c1cc(-c2c[nH]nc2C2CCCOC2)nc(NC2CCCC2)n1 CHEMBL483741 Ki 12.0 nM
O[C@H]1CC[C@H](c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)CC1 CHEMBL507249 Ki 12.0 nM
N#Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1 CHEMBL1682021 IC50 12.0 nM
COC(=O)c1c(Cc2ccc(C(=O)N[C@@H]3[C@@H]4C[C@@H]5C[C@H]3C[C@@](O)(C5)C4)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152383 IC50 12.0 nM
COC(=O)c1c(Cc2ccc(C(=O)N[C@H](CO)C(C)(C)C)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152384 IC50 12.0 nM
CCOC1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCC(S(C)(=O)=O)CC6)cccc54)n3)CC2)C1 CHEMBL2392839 IC50 12.0 nM
CCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425639 IC50 12.0 nM
COC(=O)c1c(CNC(=O)c2ccncc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679555 IC50 12.0 nM
COC(=O)c1c(CNC(=O)c2ccc(F)c(F)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679556 IC50 12.0 nM
COC(=O)c1c(CNC(=O)c2ccccc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679569 IC50 12.0 nM
CC(=O)Nc1cccc(-c2n[nH]c3cc(-c4cnn(C)c4)c(NC4CCCCC4)cc23)c1 CHEMBL2380587 IC50 12.1 nM
CCO[C@H]1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCC(S(C)(=O)=O)CC6)cccc54)n3)CC2)C1 CHEMBL3674705 IC50 12.4 nM
CC(=O)N1CCN(c2cccc3c2c(C(N)=O)cn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 CHEMBL3674735 IC50 12.4 nM
CNC(=O)CN1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245336 IC50 13.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL248176 IC50 13.0 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL507625 IC50 13.0 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1nccs1 CHEMBL1822154 IC50 13.0 nM
Cc1ncn(-c2ccc(Nc3cc(-c4nocc4-c4cn[nH]c4C)ccn3)cc2)n1 CHEMBL3100085 IC50 13.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccn(Cc2ccccc2)c(=O)c1 CHEMBL3679449 IC50 13.0 nM
COC(=O)c1c(CNC(=O)c2cnn(Cc3ccccc3)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679538 IC50 13.0 nM
COC(=O)c1c(CNC(=O)c2cccc(F)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679557 IC50 13.0 nM
COC(=O)c1c(CNC(=O)c2cccnc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679558 IC50 13.0 nM
CC(C)(C)Nc1nc(N[C@H]2CC[C@H](O)CC2)ncc1C(N)=O CHEMBL4874549 IC50 13.0 nM
CC(=O)N1CCN(c2cccc3c2c(C(N)=O)cn3-c2ccnc(N[C@H]3CC[C@H](CS(C)(=O)=O)CC3)n2)CC1 CHEMBL3674736 IC50 13.9 nM
COC(=O)c1ccc(Cn2c(C(=O)OC)c(-c3ccccc3)c3cc(Br)ccc3c2=O)cc1 CHEMBL259916 IC50 14.0 nM
O=C(Cc1cccc2cnccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682017 IC50 14.0 nM
O=C(Cc1cc(F)cc2ncccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822134 IC50 14.0 nM
COC(=O)c1c(Cc2ccc(S(C)(=O)=O)cc2)c(=O)c2ccc(C)nc2n1-c1cccc(N)c1 CHEMBL2208438 IC50 14.0 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CC[C@@H](F)C3)CC2)n1 CHEMBL2425632 IC50 14.0 nM
CCN(CC)C(=O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 CHEMBL2425633 IC50 14.0 nM
NC(=O)c1ccc(C(=O)NCc2c(-c3ncco3)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL3679424 IC50 14.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCCCC2)nc1 CHEMBL3679427 IC50 14.0 nM
COC(=O)c1c(CNC(=O)c2ccc(F)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679559 IC50 14.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(S(N)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL3674688 IC50 14.0 nM
NC(=O)c1cnc(NC2CCC(F)(F)CC2)nc1N[C@@H]1CCC[C@H](O)C1 CHEMBL4861847 IC50 14.0 nM
CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5423620 IC50 14.4 nM
CC(C)Oc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL220504 IC50 15.0 nM
CC1CCN(C(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245733 IC50 15.0 nM
CN(C)C(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL393659 IC50 15.0 nM
CNC(=O)CN1CCC[C@@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL392615 IC50 15.0 nM
Cc1n[nH]c(-c2c(C)csc2NC(=O)CN2C(=O)CCc3ccccc32)n1 CHEMBL1682012 IC50 15.0 nM
O=C(Cc1cccc2ncccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682020 IC50 15.0 nM
COC(=O)c1c(CNC(=O)c2ccc3cc[nH]c3c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679539 IC50 15.0 nM
COC(=O)c1c(CNC(=O)c2cnn(C)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679540 IC50 15.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3cc[nH]n3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679541 IC50 15.0 nM
COC(=O)c1c(CNC(=O)c2ccc(Cl)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679551 IC50 15.0 nM
COC(=O)c1c(CNC(=O)c2ccc(F)c(Cl)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679560 IC50 15.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCn5ccnc5C4)CC3)n2)CC1 CHEMBL3674726 IC50 15.2 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCN5CCCCC5C4)CC3)n2)CC1 CHEMBL3674723 IC50 15.6 nM
COc1ccc(OC)c(CNc2n[nH]c3ccnc(Oc4ccccc4)c23)c1 CHEMBL407960 Log IC50 15.85 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 pKi 15.85 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL1090356 pKi 15.85 nM
N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@@H](O)CC3)n2)CC1 CHEMBL3674729 IC50 15.9 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(-n4ccnn4)cc3)n2)cc1 CHEMBL571626 IC50 16.0 nM
O=C(Cc1ccc(F)c2cnccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822132 IC50 16.0 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CCC(F)(F)CC3)CC2)n1 CHEMBL2425631 IC50 16.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(N2CCCCC2)s1 CHEMBL3679510 IC50 16.0 nM
COC(=O)c1c(CNC(=O)c2ccc(N3CCOCC3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679542 IC50 16.0 nM
O=C(Cc1cccc2ncc(F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822133 IC50 17.0 nM
COC(=O)c1c(Cc2ccc(C(=O)N[C@H]3CC[C@H](O)CC3)cc2)c(=O)c2ccc(C)nc2n1-c1ccccc1 CHEMBL2152390 IC50 17.0 nM
COc1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4cccc(C)c4)cn3)c2)cc(OC)c1OC CHEMBL3393599 IC50 17.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCC(CCO)CC2)nc1 CHEMBL3679483 IC50 17.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3cnns3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679543 IC50 17.0 nM
COC(=O)c1c(CNC(=O)c2cccc(Cl)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679561 IC50 17.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950289 Kd apparent 17.0 nM
CC(C)(C)Nc1ncc(C(N)=O)c(N[C@@H]2CCC[C@H](O)C2)n1 CHEMBL4852708 IC50 17.0 nM
CN1CCN(C(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245534 IC50 18.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCNCC3)cc2)c(=O)c2ccc(C)nc2n1-c1ccccc1 CHEMBL2204113 IC50 18.0 nM
CC(C)n1c(=O)ccc2cnc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL3577855 IC50 18.0 nM
Cn1cc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679450 IC50 18.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N(CCO)CCO)nc1 CHEMBL3679484 IC50 18.0 nM
COC(=O)c1c(CNC(=O)c2ccc(N3CCOCC3)nc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL3679571 IC50 18.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(NC(C)(C)C)n2)CC1 CHEMBL4857485 IC50 18.0 nM
Cc1ccc2c(-c3ccnc(N[C@H]4CCN(C(=O)c5ccc(NC(=O)/C=C/CN(C)C)cc5)C4)n3)c(-c3ccccc3)nn2c1 CHEMBL5415466 IC50 18.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(S(N)(=O)=O)cc3)n2)cc1 CHEMBL585916 IC50 19.0 nM
CN(C)S(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425653 IC50 19.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCCCC2)nc1 CHEMBL3679485 IC50 19.0 nM
CN(CCO)c1ccc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679486 IC50 19.0 nM
COc1ccc(Nc2ncc(C(N)=O)c(Nc3ccccc3)n2)cc1OC CHEMBL4861369 IC50 19.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCCC(F)(F)C3)n2)CC1 CHEMBL4866929 IC50 19.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(N)=O)CC5)cccc43)n2)CC1 CHEMBL3674687 IC50 19.1 nM
CS(=O)(=O)N(CCO)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 CHEMBL3674717 IC50 19.2 nM
O=C(O)c1ccccc1Nc1nc(Nc2cccc(O)c2)ncc1Br CHEMBL243750 IC50 20.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(C(=O)O)cc1 CHEMBL259706 IC50 20.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCCCNC(=O)c1ccc(-c2n[nH]c3ccccc23)cc1 CHEMBL509847 IC50 20.0 nM
Cc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cn1 CHEMBL1761563 IC50 20.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCC(CO)CC2)nc1 CHEMBL3679487 IC50 20.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCCOC3)n2)CC1 CHEMBL4877560 IC50 20.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 Kd 20.0 nM
O=C(O)c1ccccc1Nc1nc(Nc2cccc(O)c2)ncc1F CHEMBL243749 IC50 21.0 nM
COC(=O)c1c(-c2cccc(CO)c2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL259092 IC50 21.0 nM
O=C(Cc1cccc2ncc(C(F)(F)F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822135 IC50 21.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577868 IC50 21.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCCCCC2)nc1 CHEMBL3679488 IC50 21.0 nM
CS(=O)(=O)C1CCN(c2ncc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)s2)CC1 CHEMBL3679511 IC50 21.0 nM
CS(=O)(=O)CCCOc1cccn2c(-c3ccnc(N[C@H]4CC[C@H](C(=O)N5CCC(O)CC5)CC4)n3)cnc12 CHEMBL3655582 IC50 21.6 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCN5CCCC5C4)CC3)n2)CC1 CHEMBL3674725 IC50 21.8 nM
C[C@@H](CO)Oc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL495233 pIC50 21.98 nM
C[C@@H](CO)Nc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL221227 IC50 22.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3c(-c4ccccc4)[nH]c4ccccc34)n2)CC1 CHEMBL245936 IC50 22.0 nM
CC(C)(C)Oc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923194 IC50 22.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3noc(C)n3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679544 IC50 22.0 nM
CCOC(=O)CO/N=C1\c2ccccc2-c2nc3ccccc3nc21 CHEMBL4582239 Kd 22.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(OCC3CC3)n2)cc1 CHEMBL374269 IC50 23.0 nM
COC(=O)c1c(CN2CCC(S(C)(=O)=O)CC2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204096 IC50 23.0 nM
COc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425641 IC50 23.0 nM
CCNC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577867 IC50 23.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3ncc[nH]3)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL3679572 IC50 23.0 nM
COc1cc2ncnc(NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)c2cc1OC CHEMBL3679590 IC50 23.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1 CHEMBL3655584 IC50 23.7 nM
OCCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425640 IC50 24.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425655 IC50 24.0 nM
CS(=O)(=O)C1CCN(c2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cn2)CC1 CHEMBL3679489 IC50 24.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CC[C@@H](O)C2)nc1 CHEMBL3679490 IC50 24.0 nM
O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682013 IC50 25.0 nM
COC(=O)c1ccc(C(=O)NCc2c(-c3ncco3)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679425 IC50 25.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc2c(c1)OCO2 CHEMBL3679428 IC50 25.0 nM
CC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](CS(C)(=O)=O)CC3)n2)CC1 CHEMBL3674714 IC50 25.0 nM
Clc1ccc(-c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)cc1 CHEMBL503206 Ki 26.0 nM
COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(F)cn2)cc1 CHEMBL1923186 IC50 26.0 nM
COC1CCN(c2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cn2)CC1 CHEMBL3679491 IC50 26.0 nM
COC(=O)c1c(CNC(=O)c2ccc(S(N)(=O)=O)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL3679573 IC50 26.0 nM
COC(=O)c1c(CNC(=O)c2cccc(Cl)c2)c(=O)c2ccc(OC)cc2n1-c1ccccc1 CHEMBL3679579 IC50 26.0 nM
CCOC(=O)[C@H]1CC[C@H](Nc2nccc(-n3ncc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392836 IC50 26.8 nM
O[C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1 CHEMBL3655586 IC50 26.9 nM
Clc1ccc(-c2n[nH]cc2-c2ccnc(NC3CCCCC3)n2)cc1 CHEMBL485348 Ki 27.0 nM
COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923188 IC50 27.0 nM
Cc1ncn(-c2ccc(Nc3cc(-c4nocc4-c4cn[nH]c4)ccn3)cc2)n1 CHEMBL3099963 IC50 27.0 nM
CNC(=O)C1CCN(c2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cn2)CC1 CHEMBL3679492 IC50 27.0 nM
COC(=O)c1c(CNC(=O)c2ccc(C(N)=O)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL3679574 IC50 27.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(NCCC(C)(C)O)n2)CC1 CHEMBL4851639 IC50 27.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 IC50 28.0 nM
CC(=O)NCC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245535 IC50 28.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL259812 IC50 28.0 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL259555 IC50 28.0 nM
CC(=O)N[C@H]1CC[C@H](c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)CC1 CHEMBL482753 Ki 28.0 nM
O=C(Cc1cccc2cnccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682016 IC50 28.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc(F)cc2)n1 CHEMBL243299 IC50 29.0 nM
CCNC(=O)N1CCC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL392614 IC50 29.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 Kd 29.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392826 IC50 29.0 nM
O[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425654 IC50 29.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(Cl)nc1 CHEMBL3679426 IC50 29.0 nM
O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2ncccc2c1=O)c1ccc(N2CCOCC2)nc1 CHEMBL3679430 IC50 29.0 nM
NC(=O)N1CCN(c2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cn2)CC1 CHEMBL3679493 IC50 29.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3nc(C)no3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679545 IC50 29.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCN(C5CC5)CC4)CC3)n2)CC1 CHEMBL3674720 IC50 29.6 nM
CCOc1nc(C(=O)NCc2cnccc2Cl)cc(N)c1C#N CHEMBL391789 IC50 30.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL259060 IC50 30.0 nM
c1cc(-c2nccs2)c2nc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)ncc2c1 CHEMBL1761566 IC50 30.0 nM
COC(=O)c1c(Cc2ccc(C(=O)NCCO)cc2)c(=O)c2ccc(C)nc2n1-c1ccccc1 CHEMBL2204112 IC50 30.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCNCC3)cc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204109 IC50 30.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCNCC3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL2204108 IC50 30.0 nM
COCCNc1ccc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679494 IC50 30.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3cc[nH]n3)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL3679575 IC50 30.0 nM
COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cnccc12 CHEMBL1681791 IC50 31.0 nM
O=C(Cn1c(=O)ccc2c(C(F)(F)F)cccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822148 IC50 31.0 nM
CCNC(=O)N[C@H]1CC[C@@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577871 IC50 31.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccnc(N2CCOCC2)c1 CHEMBL3679451 IC50 31.0 nM
CN(C)C1CCN(c2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cn2)CC1 CHEMBL3679495 IC50 31.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3csc(C)n3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679546 IC50 31.0 nM
CC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCC(O)CC4)CC3)n2)[C@H](C)C1 CHEMBL3674694 IC50 31.2 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 31.62 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 31.62 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC3CC3)n2)cc1 CHEMBL220658 pIC50 31.99 nM
O=C(O)c1ccccc1Nc1nc(Nc2ccccc2)ncc1Br CHEMBL390256 IC50 32.0 nM
Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 CHEMBL1614820 IC50 32.0 nM
COC(=O)c1c(CNC(=O)c2cccc(OC)c2)c(=O)c2ccc(OC)cc2n1-c1ccccc1 CHEMBL3679580 IC50 32.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@@H](O)CC3)n2)CC1 CHEMBL3674734 IC50 32.1 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5436023 IC50 32.5 nM
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(=O)NC)[nH]n1 CHEMBL427561 IC50 33.0 nM
CC[C@@H](NC(=O)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1)c1ccccc1 CHEMBL2420562 IC50 33.0 nM
CS(=O)(=O)CCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425636 IC50 33.0 nM
Oc1onc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)c1-c1ccc(F)cc1 CHEMBL3099975 IC50 33.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(N2CCC(CO)CC2)s1 CHEMBL3679512 IC50 33.0 nM
O=C([C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1)N1CCC(O)CC1 CHEMBL3655583 IC50 33.3 nM
CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 CHEMBL3674718 IC50 33.4 nM
CC(C)(C)CNc1ncc(Br)c(Nc2ccccc2C(N)=O)n1 CHEMBL5403766 IC50 33.5 nM
NC(=O)c1ccccc1Nc1ccnc(Nc2ccccc2)n1 CHEMBL428213 IC50 34.0 nM
COc1cc[nH]c1/C=C1\C(=O)Nc2cccc(C#CC(O)c3ccc(OCCCN(C)C)cc3)c21 CHEMBL241262 IC50 34.0 nM
OCC(O)COc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425638 IC50 34.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCC(O)CC2)nc1 CHEMBL3679496 IC50 34.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(NC(C)=O)cc2OC)cc(N)c1C#N CHEMBL209769 IC50 35.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccccc2F)n1 CHEMBL438515 IC50 35.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc(O)cc2)n1 CHEMBL243297 IC50 35.0 nM
CCOc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(C(F)(F)F)cn2)cc1 CHEMBL1923192 IC50 35.0 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc(OC(F)(F)F)cc2)ncc1C(F)(F)F CHEMBL1923191 IC50 35.0 nM
CN(C)C(=O)c1c(CNC(=O)c2ccc(N3CCOCC3)nc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679433 IC50 35.0 nM
COC(=O)c1c(CNC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679547 IC50 35.0 nM
COCCO[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 CHEMBL3674713 IC50 35.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(NC(C)C)n2)CC1 CHEMBL4848290 IC50 35.0 nM
OC1CCCC(c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)C1 CHEMBL482545 Ki 36.0 nM
CC(C)NC(=O)N1CCC(Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577874 IC50 36.0 nM
CN(C)C(=O)c1c(CNC(=O)c2cnc(N3CCOCC3)s2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679434 IC50 36.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(N2CCC(O)CC2)s1 CHEMBL3679513 IC50 36.0 nM
CCN1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCC(S(C)(=O)=O)CC6)cccc54)n3)CC2)CC1 CHEMBL3674719 IC50 36.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL394816 IC50 37.0 nM
CCOC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245533 IC50 37.0 nM
Cn1cc(-c2cc3[nH]nc(-c4cccc(S(N)(=O)=O)c4)c3cc2NC2CCCCC2)cn1 CHEMBL2380586 IC50 37.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCCC[C@H]3O)n2)CC1 CHEMBL4848449 IC50 37.0 nM
COc1cccc(Oc2cc(Nc3ccccc3C(N)=O)c(C(F)(F)F)cn2)c1 CHEMBL1923189 IC50 38.0 nM
CCNC(=O)c1ccc(Cc2c(C(=O)OC)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL2204107 IC50 38.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccnc(N2CCCC2)c1 CHEMBL3679452 IC50 38.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3nnn(C)n3)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL3679576 IC50 38.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(-n4cnc(-c5ccccn5)n4)cc3)n2)cc(N2CCOCC2)c1 CHEMBL584899 IC50 39.0 nM
CC(=O)N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425651 IC50 39.0 nM
COC(=O)c1c(CNC(=O)c2ccc(OC)c(OC)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679562 IC50 39.0 nM
COC(=O)c1c(CNC(=O)c2ccccc2)c(=O)c2ccccc2n1-c1ccccc1 CHEMBL3679570 IC50 39.0 nM
COC(=O)c1c(CNC(=O)c2ccc(F)c(F)c2)c(=O)c2ccc(OC)cc2n1-c1ccccc1 CHEMBL3679581 IC50 39.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 39.81 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 39.81 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 39.81 nM
CC(C)COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1984842 pKi 39.81 nM
CC(=O)N1CCC(Nc2nccc(-c3c(-c4ccc(F)cc4)nc4occn34)n2)CC1 CHEMBL1986781 pKi 39.81 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 39.81 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 39.81 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 IC50 40.0 nM
c1cc(-n2cnc(N3CCOCC3)n2)ccc1Nc1ncc2ccc(-c3cn[nH]c3)cc2n1 CHEMBL1761555 IC50 40.0 nM
Cc1cccc(NC(=O)c2ccc(Cl)o2)c1N1CCC2(CC1)OCCO2 CHEMBL1783588 IC50 40.0 nM
CC(C)n1c(=O)ccc2cnc(N[C@H]3CC[C@H](NC(=O)NC4CCCC4)CC3)nc21 CHEMBL3577869 IC50 40.0 nM
CN1CCN(c2ncc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)s2)CC1 CHEMBL3679514 IC50 40.0 nM
O=C(NCc1cn(-c2ccccc2F)c2cc(F)ccc2c1=O)c1cnn(-c2ccccc2)c1 CHEMBL3679522 IC50 40.0 nM
O=C1c2ccccc2-c2n[nH]c3cccc1c23 CHEMBL7064 IC50 40.0 nM
c1ccc2c(c1)Cc1cccc3[nH]nc-2c13 CHEMBL4462592 IC50 40.0 nM
O=C1c2ccccc2C2=NNC3=CC=CC1C32 CHEMBL252761 IC50 40.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-c3cnc4ccccn34)n2)CC1 CHEMBL397531 IC50 41.0 nM
O=C(NC1(c2ccc(F)cc2)CC1)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1 CHEMBL2420555 IC50 41.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc2nc[nH]c2c1 CHEMBL3679453 IC50 41.0 nM
O=C(Nc1cc(-c2ccnc(Nc3ccccc3)c2)ccn1)c1ccco1 CHEMBL380724 IC50 42.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(OC)cc1 CHEMBL410707 IC50 42.0 nM
O=C(Cc1cccc2ncccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682019 IC50 42.0 nM
CCOc1ccc2[nH]nc(-c3cccc(C(N)=O)c3)c2c1 CHEMBL2380576 IC50 42.8 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(O)CC5)cccc43)n2)CC1 CHEMBL3674685 IC50 42.9 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3cccc(S(C)(=O)=O)c3)n2)cc1 CHEMBL374193 pIC50 42.95 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(N)cc1 CHEMBL407956 IC50 43.0 nM
CCNC(=O)n1cc(Cn2c(C(=O)CC)c(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL406408 IC50 43.0 nM
CC(C)Nc1nccc(-c2c[nH]nc2C2CCCOC2)n1 CHEMBL485365 Ki 43.0 nM
CCOc1cc2c(-c3cccc(NC(C)=O)c3)n[nH]c2cc1C#N CHEMBL2380579 IC50 43.0 nM
CCOc1cc2c(-c3ccc(C)c(S(N)(=O)=O)c3)n[nH]c2cc1-c1cnn(C)c1 CHEMBL2380583 IC50 43.5 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc3c(c2)OCO3)ncc1C(F)(F)F CHEMBL1923201 IC50 44.0 nM
COC(=O)c1c(Cc2ccc(C(=O)NCCO)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL2152382 IC50 44.0 nM
COC(=O)c1c(Cc2ccc(C(=O)NCC(C)(C)O)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152386 IC50 44.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)C5)cccc43)n2)CC1 CHEMBL2392830 IC50 44.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccn(Cc2ccc(Cl)cc2)c(=O)c1 CHEMBL3679454 IC50 44.0 nM
CN(C)CCNC(=O)c1ccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)cc1 CHEMBL399167 IC50 45.0 nM
Cn1nnc(-c2ccc(Nc3nccc(-c4cc(C#N)cc(N5CCOCC5)c4)n3)cc2)n1 CHEMBL571434 IC50 45.0 nM
Cc1n[nH]c(-c2c(C)csc2NC(=O)Cc2cccc3ncccc23)n1 CHEMBL1682010 IC50 45.0 nM
COC(=O)c1c(Cc2ccc(C(=O)NC(C)(C)CO)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152388 IC50 45.0 nM
COC(=O)c1c(Cc2ccc(C(=O)NC3(CO)CC3)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152389 IC50 45.0 nM
CCNC(=O)c1ccc(Cc2c(C(=O)OC)n(-c3ccccc3)c3nc(C)ccc3c2=O)cc1 CHEMBL2204114 IC50 45.0 nM
CC1CCN(NC(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245935 IC50 47.0 nM
COC(=O)c1c(Cc2ccc(C(=O)N[C@H]3[C@@H]4C[C@@H]5C[C@H]3C[C@@](O)(C5)C4)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152385 IC50 47.0 nM
CNS(=O)(=O)c1ccc(Cc2c(C(=O)OC)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL2204106 IC50 47.0 nM
O=C(NC1(Cc2ccc(F)cc2)CC1)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1 CHEMBL2420551 IC50 47.0 nM
Cn1cc(C(=O)NCc2c(-c3ncco3)n(-c3ccccc3)c3ncccc3c2=O)cn1 CHEMBL3679431 IC50 47.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(NCCO)nc1 CHEMBL3679497 IC50 47.0 nM
COC(=O)c1c(CNC(=O)c2ccc(C(C)(C)C)cc2)c(=O)c2ccc(OC)cc2n1-c1ccccc1 CHEMBL3679582 IC50 47.0 nM
C/C=C/c1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL221126 pIC50 47.97 nM
O=C(Nc1cc(-c2ccnc(Nc3ccc(F)cc3)c2)ccn1)C1CCOC1 CHEMBL203839 IC50 48.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccccc2)n1 CHEMBL244839 IC50 48.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(NS(=O)(=O)c2ccccc2)cc1 CHEMBL261186 IC50 48.0 nM
CC(C)Nc1nccc(-c2c[nH]nc2-c2ccc(Cl)cc2)n1 CHEMBL451282 Ki 48.0 nM
O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1 CHEMBL1288160 IC50 48.0 nM
CC(C)C(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577866 IC50 48.0 nM
COC(=O)c1c(CNC(=O)c2ccc(Cl)c(Cl)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679563 IC50 48.0 nM
CC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(NC3CCCCC3)n2)CC1 CHEMBL3674710 IC50 48.4 nM
CCOC(=O)[C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1 CHEMBL3655585 IC50 48.9 nM
COC(=O)c1c(Cc2ccc(C(=O)N[C@@H]3[C@@H]4C[C@@H]5C[C@H]3C[C@@](N)(C5)C4)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152392 IC50 49.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(NC2CCOCC2)nc1 CHEMBL3679498 IC50 49.0 nM
CCOc1nc(C(=O)NCc2ccc([S+]([O-])c3ccccc3)cc2)cc(N)c1C#N CHEMBL240859 IC50 50.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2)cn1 CHEMBL1761554 IC50 50.0 nM
c1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cc1 CHEMBL1761567 IC50 50.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCC(O)CC3)cc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204110 IC50 50.0 nM
COC(=O)c1c(CNC(=O)c2ccc(-c3nnn(C)n3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679548 IC50 50.0 nM
CC(C)Nc1nc(N[C@H]2CC[C@H](O)CC2)ncc1C(N)=O CHEMBL4874419 IC50 50.0 nM
CC(C)(C)CNc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL5411353 IC50 50.1 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL2005792 pKi 50.12 nM
COc1cc(Nc2nccc(Nc3cc(C4CCCCC4)no3)n2)cc(OC)c1OC CHEMBL1984711 pKi 50.12 nM
CNC(=O)[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950304 IC50 51.0 nM
CN(C)C(=O)c1c(CNC(=O)c2ccc(N3CCC(CCO)CC3)nc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679445 IC50 51.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)cc1 CHEMBL3679518 IC50 52.0 nM
O=C(NCc1cn(-c2ccccc2F)c2cc(F)ccc2c1=O)c1ccc(N2CCC(CO)CC2)nc1 CHEMBL3679525 IC50 52.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@H]3CCC[C@H](O)C3)n2)CC1 CHEMBL4848796 IC50 52.0 nM
NC(=O)c1ccccc1Nc1cc(Oc2ccc(-c3cccnc3)cc2)ncc1C(F)(F)F CHEMBL1923204 IC50 53.0 nM
COC(=O)c1c(CN2CC[C@H](S(C)(=O)=O)C2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204099 IC50 53.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCC[C@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5397194 IC50 53.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NCCCO)n2)cc1 CHEMBL434560 pIC50 53.95 nM
Cc1ncn(-c2ccc(Nc3nccc(-c4cc(C#N)cc(N5CCOCC5)c4)n3)cc2)n1 CHEMBL570554 IC50 54.0 nM
COC(=O)c1c(Cc2ccc(C(=O)N[C@H]3CC[C@H](O)CC3)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152387 IC50 54.0 nM
COc1ccc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679455 IC50 54.0 nM
COC(=O)c1c(CNC(=O)c2ccc(OC)cc2)c(=O)c2ccc(OC)cc2n1-c1ccccc1 CHEMBL3679583 IC50 54.0 nM
CC(C)(C)N1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCC(S(C)(=O)=O)CC6)cccc54)n3)CC2)CC1 CHEMBL3674721 IC50 54.5 nM
COC(=O)c1c(C)csc1NC(=O)Cc1cccc2ncccc12 CHEMBL1682004 IC50 55.0 nM
O[C@H]1CC[C@H](Nc2nccc(-n3ncc4ccccc43)n2)CC1 CHEMBL2425645 IC50 55.0 nM
NS(=O)(=O)c1ccc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679456 IC50 55.0 nM
CN(C)c1ccc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cn1 CHEMBL3679499 IC50 55.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(N2CCOCC2)s1 CHEMBL3679515 IC50 55.0 nM
CO[C@H]1CCC[C@@H](Nc2nc(N[C@H]3CC[C@H](OC)CC3)ncc2C(N)=O)C1 CHEMBL4858138 IC50 55.0 nM
N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](CN4CC[C@H](O)C4)CC3)n2)CC1 CHEMBL3674701 IC50 55.5 nM
CS(=O)(=O)NCCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425637 IC50 56.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCS(=O)(=O)CC2)nc1 CHEMBL3679500 IC50 56.0 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5401511 IC50 56.1 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-c3cnc4ccccn34)n2)CC1 CHEMBL3655587 IC50 56.7 nM
CN(C)CC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245732 IC50 57.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)CCO)cc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204111 IC50 58.0 nM
CC(=O)NCCNc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL386010 IC50 59.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3cnc4ccccn34)n2)CC1 CHEMBL246543 IC50 59.0 nM
COC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL259404 IC50 59.0 nM
CCC(CC)(NC(=O)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1)c1ccccc1 CHEMBL2420571 IC50 59.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCN(C5CCC5)CC4)CC3)n2)CC1 CHEMBL3674722 IC50 59.8 nM
CCNC(=O)N1CCC[C@@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL245335 IC50 60.0 nM
CC(C)(C)OC(=O)N1CCC(NC(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)CC1 CHEMBL3640050 IC50 60.0 nM
COC(=O)c1c(CNc2ncnc3ccccc23)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3640066 IC50 60.0 nM
O=C(O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL197613 IC50 61.0 nM
CCOc1nc(C(=O)NCCNc2ccc([N+](=O)[O-])cn2)cc(N)c1C#N CHEMBL240254 IC50 61.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(C)ccc2c(=O)n1Cc1ccccc1 CHEMBL411635 IC50 61.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5ccc(Cl)cc5)nn5ccccc45)n3)C2)cc1 CHEMBL5436341 IC50 62.0 nM
COC(=O)c1c(-c2ccc(CO)cc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL258883 IC50 63.0 nM
CC(C)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CC[C@@H](C(=O)N4CCOCC4)CC3)c2n1 CHEMBL1950293 IC50 63.0 nM
O=C([C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1)N1CCOCC1 CHEMBL2425649 IC50 63.0 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 63.1 nM
CS(=O)(=O)Nc1ccc(-c2cc3c(-c4ccc(C(N)=O)cc4)ccnc3[nH]2)cc1 CHEMBL4128114 pIC50 63.1 nM
COc1ccc(C(=O)NCc2c(C(=O)N(C)C)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL3679435 IC50 64.0 nM
COC(=O)c1c(CN2CCN(S(C)(=O)=O)CC2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204095 IC50 65.0 nM
O[C@H]1CC[C@H](Nc2nccc(-n3ccc4ccccc43)n2)CC1 CHEMBL2425646 IC50 65.0 nM
CC(C)(C)OC(=O)NC1CCN(c2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cn2)CC1 CHEMBL3679501 IC50 65.0 nM
COC(=O)c1c(CNC(=O)c2ccccc2F)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679564 IC50 65.0 nM
COC(=O)c1c(CNC(=O)c2cccnc2)c(=O)c2ccc(OC)cc2n1-c1ccccc1 CHEMBL3679584 IC50 65.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NCCC(N)=O)n2)cc1 CHEMBL221315 IC50 66.0 nM
CN(C)C(=O)c1c(CNC(=O)c2ccc3ncsc3c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679436 IC50 66.0 nM
CC(C)Nc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL218194 pIC50 66.99 nM
CNCC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL393861 IC50 67.0 nM
O=C(N[C@H](CO)c1ccccc1)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1 CHEMBL2420564 IC50 67.0 nM
Cc1ccc(-c2ncn(-c3ccc(Nc4nccc(-c5cccc(N6CCOCC6)c5)n4)cc3)n2)cn1 CHEMBL2144409 IC50 67.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5ccc(F)cc5)nn5ccccc45)n3)C2)cc1 CHEMBL5396061 IC50 67.0 nM
CCCCNC(=O)C1CCN(CC(=O)Nc2cc(N)c(C#N)c(OCC)n2)CC1 CHEMBL209669 IC50 69.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c([N+](=O)[O-])cc2OC)cc(N)c1C#N CHEMBL209505 IC50 69.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(N2CCS(=O)(=O)CC2)s1 CHEMBL3679516 IC50 69.0 nM
O=C(NC1CCNCC1)c1cccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL194806 IC50 71.0 nM
CCOc1nc(C(=O)NCc2cc(OC)ccc2OC)cc(N)c1C#N CHEMBL214212 IC50 71.0 nM
CCNC(=O)N1CCC(Nc2nccc(-n3ccc4ccccc43)n2)CC1 CHEMBL392613 IC50 71.0 nM
CN1CCCN(c2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cn2)CC1 CHEMBL3679502 IC50 71.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnn(-c2ccccc2)c1 CHEMBL3679457 IC50 72.0 nM
COc1cccc(Cn2ccc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)cc2=O)c1 CHEMBL3679458 IC50 72.0 nM
COc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5F)ccc43)c2)cc(OC)c1OC CHEMBL1233748 IC50 73.0 nM
COC(=O)c1c(CNC(=O)c2ccc(F)cc2)c(=O)c2ccc(OC)cc2n1-c1ccccc1 CHEMBL3679585 IC50 73.0 nM
CC(=O)N1CCC[C@@H](C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)C1 CHEMBL202639 IC50 74.0 nM
COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(OCCO)n2)c1 CHEMBL210462 IC50 74.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245725 IC50 74.0 nM
N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425652 IC50 74.0 nM
Cn1cc(-c2c[nH]c3ncc([C@H]4CC[C@H](N5CCOCC5)CC4)cc23)cn1 CHEMBL3393596 IC50 74.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5cccc(Cl)c5)nn5ccccc45)n3)C2)cc1 CHEMBL5436350 IC50 74.0 nM
CC(C)Oc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1Cl CHEMBL439323 IC50 75.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4ccccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946333 IC50 75.0 nM
CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5424946 IC50 75.5 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC(CO)CO)n2)cc1 CHEMBL384219 IC50 76.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccccc2O)n1 CHEMBL388700 IC50 76.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccn(Cc2ccccc2Cl)c(=O)c1 CHEMBL3679459 IC50 76.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(Br)cc2OC)cc(N)c1C#N CHEMBL382639 IC50 77.0 nM
O=C(NC1(c2ccccc2)CCC1)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1 CHEMBL2420573 IC50 77.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CN)CC5)cccc43)n2)CC1 CHEMBL3674697 IC50 77.7 nM
COC(=O)c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc21 CHEMBL1682005 IC50 78.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 78.0 nM
C#C/C=C/c1c(N)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)nc1OCC CHEMBL221128 IC50 79.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1cccc(OC)c1 CHEMBL258703 IC50 79.0 nM
NCc1ccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5ccc(C(F)(F)F)cc5F)c4)c3c2)cc1 CHEMBL551024 IC50 79.0 nM
CC(C)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CC[C@@H](C(=O)NC4CC4)CC3)c2n1 CHEMBL1950292 IC50 79.0 nM
COC(=O)c1c(CNC(=O)c2ccc3cc[nH]c3c2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL3679577 IC50 79.0 nM
O=c1c(CNc2ncnc3cc(F)ccc23)cn(-c2ccccc2)c2cc(Cl)ccc12 CHEMBL3679591 IC50 79.0 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 79.43 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 79.43 nM
CC(=O)Nc1cc(N)c(C#N)c(-c2ccsc2)n1 CHEMBL2006567 pKi 79.43 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 79.43 nM
CN(C)Cc1ccc(-c2cc3c(-c4ccc(C(N)=O)cc4)ccnc3[nH]2)cc1 CHEMBL4125907 pIC50 79.43 nM
CCOc1ccc2[nH]nc(-c3cccc(NC(C)=O)c3)c2c1 CHEMBL2380575 IC50 79.5 nM
COC(=O)c1c(Cc2ccc(C(=O)NCCO)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL2204094 IC50 80.0 nM
CC(C)n1c(=O)ccc2cnc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL3577865 IC50 80.0 nM
COc1ccc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1OC CHEMBL3679477 IC50 80.0 nM
N#CC(c1ccnc(OCc2ccc(CN3CCOCC3)cc2)n1)c1nc2ccccc2s1 CHEMBL3545213 IC50 80.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3ccsc3)n2)cc1 CHEMBL219112 pIC50 80.91 nM
NC(=O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 CHEMBL199136 IC50 81.0 nM
O=C(Cc1ccc(C(F)(F)F)c2ncccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1822137 IC50 81.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCN(CCO)CC2)nc1 CHEMBL3679503 IC50 81.0 nM
CC(=O)N1CCCC(C(=O)Nc2cc(-c3ccnc(Nc4ccccc4)c3)ccn2)C1 CHEMBL203225 IC50 82.0 nM
O=C(O)c1ccccc1Nc1nc(Nc2ccccc2)ncc1F CHEMBL244793 IC50 82.0 nM
COC(=O)c1c(Cc2ccc(S(C)(=O)=O)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL2204093 IC50 82.0 nM
O=C(O)c1ccc2c(c1)nc(N[C@H]1CC[C@H](O)CC1)c1nccn12 CHEMBL2420586 IC50 82.0 nM
CN(C)C(=O)c1c(CNC(=O)c2cnc(N3CCC(CCO)CC3)s2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679447 IC50 82.0 nM
CCOC1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCC(S(C)(=O)=O)CC6)cccc54)n3)CC2)CC1 CHEMBL3674703 IC50 82.7 nM
NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5403678 IC50 82.7 nM
CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5411160 IC50 82.8 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCOCC2)nc1 CHEMBL3679460 IC50 84.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC3CCC3)n2)cc1 CHEMBL221229 pIC50 84.92 nM
CC(=O)N1CCCC(C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)C1 CHEMBL206466 IC50 85.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3ncccc3c2)n1 CHEMBL244580 IC50 85.0 nM
CCNC(=O)N1CCC(Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577873 IC50 85.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccccc1 CHEMBL258676 IC50 86.0 nM
CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5408675 IC50 86.5 nM
O[C@H]1CC[C@H](Nc2nccc(-c3cnc4ccccn34)n2)CC1 CHEMBL2425648 IC50 86.6 nM
CCOc1nc(NC(=O)CN2CCC(C(=O)NC(C)C)CC2)cc(N)c1C#N CHEMBL377578 IC50 87.0 nM
CC(=O)Nc1ccc(Nc2nc(NCC(C)(C)C)ncc2C(N)=O)cc1 CHEMBL5403621 IC50 87.7 nM
CC(C)COc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL218658 pIC50 87.9 nM
CO[C@H]1CC[C@@H](C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)CC1 CHEMBL202676 IC50 88.0 nM
CN(C)c1cc(C(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)ccn1 CHEMBL3679461 IC50 88.0 nM
COC(=O)c1cccc(Cn2c(C(=O)OC)c(-c3ccccc3)c3cc(Br)ccc3c2=O)c1 CHEMBL260126 IC50 89.0 nM
O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc2scnc2c1 CHEMBL3679462 IC50 89.0 nM
C[C@H]1CN(C(=O)c2ccc(NC(=O)/C=C/CN(C)C)cc2)C[C@@H]1Nc1nccc(-c2c(-c3ccccc3)nn3ccccc23)n1 CHEMBL5410683 IC50 89.0 nM
N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CCC[C@H](O)C3)n2)CC1 CHEMBL3674707 IC50 89.2 nM
COc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cc1F CHEMBL1761565 IC50 90.0 nM
Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCC2(CC1)OCCO2 CHEMBL1783587 IC50 90.0 nM
O=C(NCc1cn(-c2ccccc2Cl)c2cc(Cl)ccc2c1=O)c1ccc(N2CCOCC2)cc1 CHEMBL3679519 IC50 90.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946646 IC50 91.0 nM
COC(=O)c1c(Cc2ccc(S(C)(=O)=O)cc2)c(=O)c2cccnc2n1-c1ccccc1 CHEMBL2152391 IC50 91.0 nM
CN(C)C(=O)c1c(CNC(=O)c2ccc(N3CCCCC3)nc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679448 IC50 91.0 nM
CCNC(=O)N1CCC(Nc2ncc(C#N)c(-c3c[nH]c4cc(F)ccc34)n2)CC1 CHEMBL248370 IC50 92.0 nM
O=C(NC1(c2ccccc2)CC1)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1 CHEMBL2420572 IC50 92.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL3924132 IC50 92.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NCCO)n2)cc1 CHEMBL218219 pIC50 92.9 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NCCNC(N)=O)n2)cc1 CHEMBL220810 pIC50 92.9 nM
Cc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1F CHEMBL243518 IC50 93.0 nM
COc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5Cl)ccc43)c2)cc(OC)c1OC CHEMBL2376910 IC50 93.0 nM
CCOc1cc2c(-c3cccc(S(N)(=O)=O)c3)n[nH]c2cc1-c1cnn(C)c1 CHEMBL2380582 IC50 93.7 nM
O[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCCCC5)cccc43)n2)CC1 CHEMBL3674684 IC50 93.9 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCCCC5)cccc43)n2)CC1 CHEMBL2392829 IC50 94.0 nM
COC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1Cc1ccccc1 CHEMBL410318 IC50 95.0 nM
COC(=O)c1c(C)csc1NC(=O)Cc1cccc2nccnc12 CHEMBL1682003 IC50 95.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@H]3CCC[C@@H](O)C3)n2)CC1 CHEMBL4852680 IC50 95.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC3CCCC3)n2)cc1 CHEMBL375795 pIC50 95.94 nM
c1cncc(-c2ncn(-c3ccc(Nc4nccc(-c5cccc(N6CCOCC6)c5)n4)cc3)n2)c1 CHEMBL571023 IC50 97.0 nM
Cc1ncn(-c2ccc(Nc3cc(-c4nocc4-c4c(C)n[nH]c4C)ccn3)cc2)n1 CHEMBL3100086 IC50 98.0 nM
CN(C)C(=O)c1c(CNC(=O)c2cnc(N3CCC(CO)CC3)s2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL3679446 IC50 98.0 nM
COc1cc(Nc2nc(NCC(C)(C)C)ncc2C(N)=O)ccc1O CHEMBL5396069 IC50 98.0 nM
Fc1cc(-c2cc[nH]/c(=N/c3ccc(-n4cnc(N5CCOCC5)n4)cc3)n2)cc(N2CCOCC2)c1 CHEMBL585951 IC50 99.0 nM