C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F CHEMBL4546504 IC50 0.059 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCCC3=O)cc2)ncc1Cl CHEMBL3220502 IC50 0.24 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)cc2)c1 CHEMBL3393608 IC50 0.5 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)c(F)c2)ncc1Cl CHEMBL3220499 IC50 0.51 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2F)ncc1Cl CHEMBL3220496 IC50 0.6 nM
COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 CHEMBL3220497 IC50 0.68 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 CHEMBL3220498 IC50 0.69 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4cccnc4)n3)cc2)c1 CHEMBL3393607 IC50 0.7 nM
N#Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 CHEMBL3220500 IC50 0.71 nM
O=C1NCc2[nH]c3c(ccc4cnc(Nc5cccc(F)c5)cc43)c21 CHEMBL1801376 IC50 1.0 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl CHEMBL3220493 IC50 1.0 nM
COc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 CHEMBL3220494 IC50 1.0 nM
Cc1cc(NC(=O)c2cccc(NC(=O)/C=C/CN(C)C)c2)ccc1Nc1nccc(-c2cccnc2)n1 CHEMBL2216824 IC50 1.0 nM
Cc1ccc2c(-c3ccnc(N[C@H]4CCN(C(=O)c5ccc(NC(=O)/C=C/CN(C)C)cc5)C4)n3)c(-c3ccccc3)nn2c1 CHEMBL5415466 IC50 1.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 1.585 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-c3ccc(CN4CCOCC4)nc3)c3ccccc23)cc1 CHEMBL381743 IC50 2.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(/C=C/c5ccccc5)cc43)c21 CHEMBL1801373 IC50 2.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950289 Kd apparent 2.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5432340 IC50 2.0 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(F)cc2)ncc1Cl CHEMBL3217784 IC50 2.5 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 2.512 nM
COc1c(NC(=O)Nc2ccc(-c3ccc(CN4CCOCC4)nc3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O CHEMBL451523 IC50 3.0 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL3220495 IC50 3.0 nM
COc1cc(S(C)(=O)=O)c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1 CHEMBL378627 pKi 3.162 nM
CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N CHEMBL210618 pKi 3.981 nM
CCOc1nc(C(=O)NCc2ccccc2S(N)(=O)=O)cc(N)c1C#N CHEMBL377408 pKi 3.981 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 3.981 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5ccc(F)cc5)nn5ccccc45)n3)C2)cc1 CHEMBL5396061 IC50 4.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5cccc(Cl)c5)nn5ccccc45)n3)C2)cc1 CHEMBL5436350 IC50 4.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 4.6 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2[C@H]2CC[C@H](O)CC2)n1 CHEMBL97162 IC50 5.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3c(-c4ccccc4)[nH]c4ccccc34)n2)CC1 CHEMBL245936 IC50 5.0 nM
O=C(Cn1c(=O)ccc2cc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822146 IC50 5.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1Nc1ccccc1 CHEMBL4878046 IC50 5.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@H](O)C3)n2)CC1 CHEMBL4847078 IC50 5.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCCOC3)n2)CC1 CHEMBL4877560 IC50 5.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCC[C@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5397194 IC50 5.0 nM
C[C@H]1CN(C(=O)c2ccc(NC(=O)/C=C/CN(C)C)cc2)C[C@@H]1Nc1nccc(-c2c(-c3ccccc3)nn3ccccc23)n1 CHEMBL5410683 IC50 5.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5413843 IC50 5.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 5.012 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 Kd 5.8 nM
CN(C)c1c(-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)cnn1Cc1ccccc1 CHEMBL1094014 Ki 6.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@@H](O)C3)n2)CC1 CHEMBL4853125 IC50 6.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 6.31 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(OCC(F)(F)F)nccn23)n1 CHEMBL2001957 pKi 6.31 nM
CCOc1nc(C(=O)NCc2ccccc2S(N)(=O)=O)cc(N)c1Cl CHEMBL2006581 pKi 6.31 nM
CC(C)Oc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL2000429 pKi 6.31 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1C#N CHEMBL210963 pKi 6.31 nM
CCOc1nc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc(N)c1C#N CHEMBL2004355 pKi 6.31 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5ccc(Cl)cc5)nn5ccccc45)n3)C2)cc1 CHEMBL5436341 IC50 7.0 nM
CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5423620 IC50 7.56 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 CHEMBL1682015 IC50 8.0 nM
O=C(Cn1c(=O)ccc2cnccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822140 IC50 8.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)c2)cc1 CHEMBL5410247 IC50 8.3 nM
CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5411160 IC50 8.56 nM
O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682014 IC50 9.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 Kd 9.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946646 IC50 9.0 nM
N#Cc1ccc2c(ccc(=O)n2CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c1 CHEMBL1822151 IC50 10.0 nM
N#Cc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 CHEMBL1822152 IC50 10.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4ccccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946333 IC50 10.0 nM
CNC(=O)[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950304 IC50 10.0 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1Cl CHEMBL377383 pKi 10.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1Cl CHEMBL210928 pKi 10.0 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL1090356 pKi 10.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 EC50 10.0 nM
CCOc1nc(C(=O)NCc2ccc(-c3ccc(C(=O)O)cc3)nc2)cc(N)c1C#N CHEMBL211584 IC50 11.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(-c5cccc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801380 IC50 11.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946647 IC50 11.0 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5401511 IC50 11.9 nM
O=C(Cn1c(=O)ccc2cc(OC(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822149 IC50 12.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCn5cnnc5C4)CC3)n2)CC1 CHEMBL2392840 IC50 12.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C4CCCC4)c3n2)CC1 CHEMBL3577877 IC50 12.0 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 12.59 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL424872 pKi 12.59 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1995832 pKi 12.59 nM
Cn1cnc(-c2c(Br)csc2NC(=O)CN2C(=O)CCc3ncccc32)n1 CHEMBL1822305 IC50 13.0 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CCC(O)CC3)CC2)n1 CHEMBL2425628 Kd 13.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1NC12CC(C1)C2 CHEMBL4862452 IC50 13.0 nM
CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5436023 IC50 13.0 nM
CC1CCN(C(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245733 IC50 14.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@H]4CC[C@@H](O)CC4)c3n2)cc1 CHEMBL1946340 IC50 14.0 nM
CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5429577 IC50 14.8 nM
CCNC(=O)N1CCC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL392614 IC50 15.0 nM
O=C(Cn1c(=O)ccc2cc(F)c(F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822145 IC50 15.0 nM
C[C@@H]1CN(C(=O)c2ccc(NC(=O)/C=C/CN(C)C)cc2)C[C@H]1Nc1nccc(-c2c(-c3ccccc3)nn3ccccc23)n1 CHEMBL5398275 IC50 15.0 nM
CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5408675 IC50 15.4 nM
CC(C)Cn1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL1965423 pKi 15.85 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 15.85 nM
COc1c(NC(=O)c2cc3cccc(NC(=O)c4ccc(NC5CC5)nc4)c3s2)cc(C(C)(C)C)cc1NS(C)(=O)=O CHEMBL243575 IC50 16.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC(CCO)CCO)nc21 CHEMBL1090089 Kd 16.0 nM
C[C@H](CS(C)(=O)=O)Nc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1 CHEMBL1232769 Kd 16.0 nM
CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5424946 IC50 16.3 nM
NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5398642 IC50 16.6 nM
O[C@H]1CC[C@H](c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)CC1 CHEMBL507249 IC50 17.0 nM
O[C@H]1CC[C@H](Nc2nccc(-c3c[nH]nc3C3CCCOC3)n2)CC1 CHEMBL1089007 Ki 17.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1cscn1 CHEMBL1822309 IC50 17.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2cnn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 CHEMBL2392832 IC50 17.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCC[C@@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5406036 IC50 17.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCCC[C@@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5408895 IC50 17.0 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1ncn[nH]1 CHEMBL1822139 IC50 18.0 nM
CC(C)n1c(=O)ccc2cnc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL3577855 IC50 18.0 nM
CC(C)(C)Nc1nc(N[C@H]2CC[C@H](O)CC2)ncc1C(N)=O CHEMBL4874549 IC50 18.0 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 pKi 19.95 nM
CCOc1nc(C(=O)NCc2cccnc2)cc(N)c1C#N CHEMBL209534 pKi 19.95 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL2003657 pKi 19.95 nM
CC(=O)N1CCC(Nc2nccc(-c3c(-c4ccc(F)cc4)nc4occn34)n2)CC1 CHEMBL1986781 pKi 19.95 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 CHEMBL2392833 IC50 20.0 nM
O=C(Cn1c(=O)ccc2cnc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822141 IC50 21.0 nM
O=C(Cn1c(=O)ccc2ccc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822147 IC50 21.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ncc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 CHEMBL2425635 IC50 21.0 nM
C[C@@H]1CC[C@@H](Nc2nc(NC3(C)CC3)ncc2C(N)=O)C[C@H]1O CHEMBL4872066 IC50 21.0 nM
CNC(=O)CN1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245336 IC50 22.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(/C=C/c5ccc(CN6CCOCC6)cc5)cc43)c21 CHEMBL1801374 IC50 22.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@H]4CC[C@@H](C(N)=O)CC4)c3n2)cc1 CHEMBL1946495 IC50 22.0 nM
O=C(Cc1ccc(C(F)(F)F)c2ncccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1822137 IC50 24.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392825 IC50 24.0 nM
CS(=O)(=O)CCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2390974 IC50 24.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL248176 IC50 25.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4ccc(F)cc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946837 IC50 25.0 nM
O=C(Nc1cnn(-c2cccc(C(=O)Nc3cnn(C4CCNCC4)c3)c2)c1)Nc1ccccc1Cl CHEMBL3355177 IC50 25.0 nM
COCC(C)(C)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(C)nccn23)n1 CHEMBL1982563 pKi 25.12 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1 CHEMBL1090360 pKi 25.12 nM
Nc1nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc2n1CC1CC1 CHEMBL1982874 pKi 25.12 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(NC(C)=O)cc2OC)cc(N)c1C#N CHEMBL209769 IC50 26.0 nM
CN1CCN(C(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245534 IC50 26.0 nM
N#Cc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1ncn[nH]1 CHEMBL1682018 IC50 26.0 nM
N[C@H]1CC[C@H](Nc2ncc3nc(Nc4ccccc4F)n(C4CCCC4)c3n2)CC1 CHEMBL1946334 IC50 26.0 nM
CCNC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577867 IC50 26.0 nM
COc1ccc(Nc2ncc(C(N)=O)c(Nc3ccccc3)n2)cc1OC CHEMBL4861369 IC50 26.0 nM
CCOC(=O)[C@H]1CC[C@H](Nc2nccc(-n3ncc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392836 IC50 27.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 CHEMBL2425634 IC50 27.0 nM
C[C@@H]1CN(C(=O)c2ccc(NC(=O)/C=C/CN(C)C)cc2)C[C@@H]1Nc1nccc(-c2c(-c3ccccc3)nn3ccccc23)n1 CHEMBL5395598 IC50 27.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCNCC3)cc2)c(=O)c2ccc(C)nc2n1-c1ccccc1 CHEMBL2204113 IC50 28.0 nM
COC1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(OCCCS(C)(=O)=O)cccc54)n3)CC2)CC1 CHEMBL2425630 IC50 28.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCCC[C@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5433713 IC50 28.0 nM
Fc1ccc(-c2[nH]c(C3CCCCC3)nc2-c2ccncc2)cc1 CHEMBL69331 IC50 29.0 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1ncco1 CHEMBL1822307 IC50 29.0 nM
CC(C)C(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577866 IC50 29.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)c(F)cc32)cs1 CHEMBL4874573 IC50 29.0 nM
NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5403678 IC50 29.4 nM
OC1(c2nc(-c3ccc(F)cc3)c(-c3ccnc(NC4CCCCC4)c3)o2)CCNCC1 CHEMBL121405 IC50 30.0 nM
C[C@@H](CO)Nc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL221227 IC50 30.0 nM
COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 CHEMBL259060 IC50 30.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(-c5ccccc5F)cc43)c21 CHEMBL1801378 IC50 30.0 nM
CNC(=O)CN1CCC[C@@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL392615 IC50 31.0 nM
Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 CHEMBL1614820 IC50 31.0 nM
C[C@@H]1CC[C@@H](Nc2nc(NC(C)(C)C)ncc2C(N)=O)C[C@H]1O CHEMBL4847106 IC50 31.0 nM
CC(C)(C)Nc1ncc(C(N)=O)c(N[C@@H]2CCC[C@H](O)C2)n1 CHEMBL4852708 IC50 31.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 31.62 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(CC4CC4)nccn23)n1 CHEMBL1991800 pKi 31.62 nM
CC(C)Cn1c(N)nc2c(F)cc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL2004419 pKi 31.62 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822138 IC50 32.0 nM
COC(=O)c1c(Cc2ccc(S(C)(=O)=O)cc2)c(=O)c2ccc(C)nc2n1-c1cccc(N)c1 CHEMBL2208438 IC50 32.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCC(O)CC4)CC3)n2)CC1 CHEMBL2392838 IC50 33.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(/C=C/c5cccc(CCN6CCOCC6)c5)cc43)c21 CHEMBL1801375 IC50 34.0 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccc(Cl)cc2)ncc1Cl CHEMBL3220501 IC50 34.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCC5CCS(=O)(=O)C5)cccc43)n2)CC1 CHEMBL2392831 IC50 35.0 nM
O=C(Cn1c(=O)ccn2nc(C(F)(F)F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822144 IC50 36.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 CHEMBL2392827 IC50 36.0 nM
O=C(NCCCN1CCCC1=O)c1cnccc1Nc1nc(-c2cc(Br)ccc2F)nc2nccnc12 CHEMBL234655 IC50 37.0 nM
CN(C)C(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL393659 IC50 37.0 nM
CC(C)Oc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL220504 IC50 38.0 nM
COCCOc1cncc(-c2cc3c(ccc4c5c([nH]c43)CNC5=O)cn2)c1 CHEMBL1801382 IC50 38.0 nM
O=C(Cn1c(=O)ccc2nc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822142 IC50 38.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@@H]4CCOC4)c3n2)CC1 CHEMBL1950303 IC50 38.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 39.81 nM
CC(C)(O)CNc1nccc(-c2c(-c3ccc(F)cc3F)nc3c(CC4CC4)nccn23)n1 CHEMBL1994040 pKi 39.81 nM
CC(C)COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1984842 pKi 39.81 nM
CCOc1nc(C(=O)NCc2ccncc2)cc(N)c1C#N CHEMBL1984206 pKi 39.81 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 39.81 nM
CC(Nc1nccc(-c2c(-c3ccc(F)cc3)nc3occn23)n1)c1ccccc1 CHEMBL1990288 pKi 39.81 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1991678 pKi 39.81 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 IC50 40.0 nM
CCOC(=O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392837 IC50 40.0 nM
O=C1c2ccccc2-c2n[nH]c3cccc1c23 CHEMBL7064 IC50 40.0 nM
c1ccc2c(c1)Cc1cccc3[nH]nc-2c13 CHEMBL4462592 IC50 40.0 nM
O=C1c2ccccc2C2=NNC3=CC=CC1C32 CHEMBL252761 IC50 40.0 nM
N#Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1 CHEMBL1682021 IC50 41.0 nM
Cc1n[nH]c(-c2c(C)csc2NC(=O)CN2C(=O)CCc3ccccc32)n1 CHEMBL1682012 IC50 42.0 nM
O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682013 IC50 42.0 nM
O=C(Cc1cccc2ncccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682020 IC50 42.0 nM
O=C(Cc1cccc2cnccc12)Nc1scc(Cl)c1-c1ncn[nH]1 CHEMBL1682017 IC50 43.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)NC2CCCC(Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5437715 IC50 44.0 nM
N#CCc1cnc(-c2ccc3c(c2)CCO3)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5405404 IC50 44.0 nM
N#CCc1cnc(-c2ccc(Cl)c(Cl)c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5418449 IC50 44.2 nM
CN(C)CC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245732 IC50 45.0 nM
CC(=O)NCC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245535 IC50 46.0 nM
COc1ccc(Nc2ncc3nc(Nc4c(F)cccc4F)n(C4CCCC4)c3n2)cc1 CHEMBL1946328 IC50 46.0 nM
Fc1ccccc1Nc1nc2cnc(NC3CCCCC3)nc2n1C1CCCC1 CHEMBL1946332 IC50 46.0 nM
CN1CCN(c2ccc3c(n2)nc(-c2ccc(F)cc2)n3-c2ccnc(NC3CCCC3)n2)CC1 CHEMBL120185 IC50 47.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(OCC3CC3)n2)cc1 CHEMBL374269 IC50 47.0 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CC[C@@H](O)C3)CC2)n1 CHEMBL2425629 IC50 47.0 nM
CCOC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245533 IC50 49.0 nM
CC(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392834 IC50 49.0 nM
O[C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1 CHEMBL3655586 IC50 49.4 nM
O=C(Cc1cccc2cnccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682016 IC50 50.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCNCC3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL2204108 IC50 50.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL3220466 IC50 50.0 nM
CC(C)Oc1nccn2c(-c3ccnc(NCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1984700 pKi 50.12 nM
Cc1cn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc2c(C)n1 CHEMBL2000408 pKi 50.12 nM
Fc1ccc(-c2nc3cnccn3c2-c2ccnc(NCC3CC3)n2)cc1 CHEMBL1990904 pKi 50.12 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3cnccn23)n1 CHEMBL1991395 pKi 50.12 nM
CS(=O)(=O)CCCOc1cccn2c(-c3ccnc(N[C@H]4CC[C@H](C(=O)N5CCC(O)CC5)CC4)n3)cnc12 CHEMBL3655582 IC50 50.3 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CCC(F)(F)CC3)CC2)n1 CHEMBL2425631 IC50 51.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C4CCOCC4)c3n2)cc1 CHEMBL1946341 IC50 52.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)cnc32)cs1 CHEMBL4857979 IC50 52.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1 CHEMBL3655584 IC50 52.7 nM
N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1nccs1 CHEMBL1822308 IC50 53.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-c3cnc4ccccn34)n2)CC1 CHEMBL397531 IC50 55.0 nM
N#CCc1cnc(-c2ccc(Cl)c(Cl)c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)NC3CC3)C2)n1 CHEMBL5436709 IC50 55.8 nM
O=C([C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1)N1CCC(O)CC1 CHEMBL3655583 IC50 55.9 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 56.0 nM
CCN(CC)C(=O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 CHEMBL2425633 IC50 57.0 nM
COC(=O)N1CCC(n2nc(-c3ccnc(NC4CCOCC4)c3)n(-c3ccc4ccccc4c3)c2=O)CC1 CHEMBL1644646 IC50 58.0 nM
CN(C)c1ccc(-c2cnc3[nH]cc(-c4cn[nH]c4)c3c2)cc1 CHEMBL3393595 IC50 59.0 nM
O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644638 IC50 61.0 nM
CCNC(=O)N[C@H]1CC[C@@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577871 IC50 61.0 nM
CC1CCN(NC(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245935 IC50 62.0 nM
N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1nccs1 CHEMBL1822306 IC50 62.0 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(Cl)nccn23)n1 CHEMBL1969735 pKi 63.1 nM
Fc1ccc(-c2nc3occn3c2-c2ccnc(NC3CCNCC3)n2)cc1 CHEMBL1971186 pKi 63.1 nM
COC(=O)c1c(Cc2ccc(C(=O)NCCO)cc2)c(=O)c2ccc(C)nc2n1-c1ccccc1 CHEMBL2204112 IC50 64.0 nM
CS(=O)(=O)CCCOc1cccc2c1ccn2-c1ccnc(N[C@H]2CC[C@H](C(=O)N3CC[C@@H](F)C3)CC2)n1 CHEMBL2425632 IC50 64.0 nM
CC(C)n1c(=O)ccc2cnc(N[C@H]3CC[C@H](NC(=O)NC4CCCC4)CC3)nc21 CHEMBL3577869 IC50 65.0 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncco1 CHEMBL1822153 IC50 66.0 nM
CC(C)Nc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 CHEMBL1946331 IC50 66.0 nM
CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@@](C)(O)CC3)n2)CC1 CHEMBL2392835 IC50 66.0 nM
CN(C)CCn1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3352845 IC50 66.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577868 IC50 66.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5394033 IC50 66.1 nM
S=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1784650 IC50 66.5 nM
CCNC(=O)N1CCC(Nc2ncc(C#N)c(-c3c[nH]c4cc(F)ccc34)n2)CC1 CHEMBL248370 IC50 67.0 nM
CC(C)Oc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1Cl CHEMBL439323 IC50 68.0 nM
O=C(Cc1ccc(F)c2cnccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822132 IC50 68.0 nM
O=C(Cn1c(=O)ccc2ccc(OC(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822150 IC50 68.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CO)CC5)cccc43)n2)CC1 CHEMBL2392828 IC50 68.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC3CC3)n2)cc1 CHEMBL220658 IC50 69.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644618 IC50 69.0 nM
Cc1ccc2c(c1)N(Cc1cc(F)cc3c1OCOC3)C(=O)/C2=N\O CHEMBL551140 Ki 70.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(N)c2)n1 CHEMBL522387 IC50 70.0 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCNCC3)cc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204109 IC50 70.0 nM
C[C@H]1CN(C(=O)c2ccc(NC(=O)/C=C/CN(C)C)cc2)C[C@H]1Nc1nccc(-c2c(-c3ccccc3)nn3ccccc23)n1 CHEMBL5398852 IC50 70.0 nM
O=C(Cn1c(=O)ccn2nccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822143 IC50 74.0 nM
O=C(NC1COC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)cnc32)cs1 CHEMBL4872493 IC50 74.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)ncc32)cs1 CHEMBL4877727 IC50 74.0 nM
Cc1nc2c(cnn2-c2csc(C(=O)NC3COC3)c2)cc1Nc1c(F)cccc1Cl CHEMBL4845770 IC50 74.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(-c5cncc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801381 IC50 75.0 nM
Cn1c(NC[C@@H](N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL585902 IC50 76.0 nM
O=C1NCCc2[nH]c3c(ccc4cnc(/C=C/c5cccc(CCN6CCOCC6)c5)cc43)c21 CHEMBL1801385 IC50 76.0 nM
CN(C)S(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425653 IC50 76.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL3924132 IC50 76.0 nM
CCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425639 IC50 79.0 nM
CC(C)Nc1nc(N[C@H]2CC[C@H](O)CC2)ncc1C(N)=O CHEMBL4874419 IC50 79.0 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 79.43 nM
Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL1990496 pKi 79.43 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 79.43 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 79.43 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 pKi 79.43 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL2005792 pKi 79.43 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 79.43 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 79.43 nM
CC(=O)NCCNc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL386010 IC50 81.0 nM
Cc1n[nH]c(-c2c(C)csc2NC(=O)Cc2cccc3ncccc23)n1 CHEMBL1682010 IC50 81.0 nM
CC(C)(C)C(=O)N1CCC[C@H](Nc2nccc(-n3c(CC#N)cnc3-c3ccc(Cl)c(Cl)c3)n2)C1 CHEMBL5403895 IC50 81.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Br CHEMBL3220467 IC50 82.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C(C)C)c3n2)cc1 CHEMBL1946336 IC50 83.0 nM
CC(C)Nc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL218194 IC50 84.0 nM
CNCC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL393861 IC50 85.0 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(/C=C/c5ccccc5)cc43)c21 CHEMBL1801390 IC50 85.0 nM
CCOC1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCC(S(C)(=O)=O)CC6)cccc54)n3)CC2)C1 CHEMBL2392839 IC50 86.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NCCC(N)=O)n2)cc1 CHEMBL221315 IC50 87.0 nM
CCNC(=O)c1ccc(Cc2c(C(=O)OC)n(-c3ccccc3)c3nc(C)ccc3c2=O)cc1 CHEMBL2204114 IC50 87.0 nM
CCNC(=O)N1CCC[C@@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL245335 IC50 88.0 nM
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O)[C@@H](C)O CHEMBL5170124 IC50 89.0 nM
O=C(Cc1cccc2ncccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1682019 IC50 90.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2)ncc1C(F)(F)F CHEMBL3220469 IC50 90.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2)cn1 CHEMBL1761554 IC50 90.0 nM
N#CC(c1ccnc(OCc2ccc(CN3CCOCC3)cc2)n1)c1nc2ccccc2s1 CHEMBL3545213 IC50 90.0 nM
O=C(Cc1cccc2ncc(F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822133 IC50 92.0 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O CHEMBL5179856 IC50 92.0 nM
O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644615 IC50 93.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 CHEMBL4874134 IC50 93.0 nM
CCNC(=O)c1ccc(Cc2c(C(=O)OC)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL2204107 IC50 94.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 95.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3cccc(S(C)(=O)=O)c3)n2)cc1 CHEMBL374193 IC50 97.0 nM
O=c1n(C2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644639 IC50 97.0 nM
O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644642 IC50 97.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425655 IC50 97.0 nM
COc1ccc(CNc2nccc(-c3[nH]c(-c4ccccc4)nc3-c3ccccc3)n2)cc1 CHEMBL68572 IC50 98.0 nM
Fc1cc(-c2cc[nH]/c(=N/c3ccc(-n4cnc(N5CCOCC5)n4)cc3)n2)cc(N2CCOCC2)c1 CHEMBL585951 IC50 99.0 nM
CCOc1nc(NC(=O)Cc2cc(OC)c([N+](=O)[O-])cc2OC)cc(N)c1C#N CHEMBL209505 IC50 100.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC(CO)CO)n2)cc1 CHEMBL384219 IC50 100.0 nM
Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Nc3ccnc4ccc(N)cc34)cc2)c1 CHEMBL570904 IC50 100.0 nM
COc1ccc(CNc2nnc(Sc3ncc([N+](=O)[O-])s3)s2)cc1 CHEMBL599110 IC50 100.0 nM
COc1ccc(CCNc2nnc(Sc3ncc([N+](=O)[O-])s3)s2)cc1OC CHEMBL599111 IC50 100.0 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 100.0 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 100.0 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1 CHEMBL363648 pKi 100.0 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)C(=O)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1971149 pKi 100.0 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 100.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 100.0 nM
CC[C@@H](NC(=O)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1)c1ccccc1 CHEMBL2420562 IC50 100.0 nM
CCOC(=O)[C@H]1CC[C@H](Nc2nccc(-c3cnc4c(OCc5ccccc5)cccn34)n2)CC1 CHEMBL3655585 IC50 104.3 nM
O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644625 IC50 110.0 nM
O[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425654 IC50 110.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@H]3CCC[C@@H](O)C3)n2)CC1 CHEMBL4852680 IC50 110.0 nM
CC(C)(C)CNc1ncc(Br)c(Nc2ccccc2C(N)=O)n1 CHEMBL5403766 IC50 112.9 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(NC(C)C)n2)CC1 CHEMBL4848290 IC50 113.0 nM
CCNC(=O)N1CCC(Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577873 IC50 114.0 nM
CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@H]3CCC[C@H](O)C3)n2)CC1 CHEMBL4848796 IC50 114.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 Kd 120.0 nM
CCOc1nc(C(=O)NCc2cc(OC)ccc2OC)cc(N)c1C#N CHEMBL214212 IC50 120.0 nM
CC(C)NC(=O)c1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL220812 IC50 120.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C4CCCC4)c3n2)cc1 CHEMBL1946325 IC50 120.0 nM
O=C(NC1(Cc2ccc(F)cc2)CC1)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1 CHEMBL2420551 IC50 120.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL3040440 IC50 120.0 nM
NC(=O)c1cnc(N[C@@H]2CCC[C@H](O)C2)nc1NC12CC(C1)C2 CHEMBL4877655 IC50 120.0 nM
Cn1cc(-c2c[nH]c3ncc([C@H]4CC[C@H](N5CCOCC5)CC4)cc23)cn1 CHEMBL3393596 IC50 123.0 nM
CC(C)(O)c1cccn2c(-c3ccnc(N[C@H]4CC[C@H](NS(C)(=O)=O)CC4)n3)cnc12 CHEMBL3655580 IC50 123.3 nM
CN(C)S(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-c3cnc4c(C(C)(C)O)cccn34)n2)CC1 CHEMBL3655581 IC50 123.8 nM
Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1 CHEMBL1682011 IC50 125.0 nM
O=C(C1CC1)N1CCC[C@H](Nc2nccc(-n3c(-c4ccc5ccccc5c4)nc4ccc(O)cc43)n2)C1 CHEMBL5437462 IC50 125.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 125.89 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 125.89 nM
Cc1nccn2c(-c3ccnc(NCCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1978200 pKi 125.89 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 125.89 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 125.89 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 125.89 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 125.89 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 125.89 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1987648 pKi 125.89 nM
c1ccc(-c2nc(-c3ccccc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL69228 IC50 130.0 nM
CCOc1nc(NC(=O)CN2CCC(C(=O)NC(C)C)CC2)cc(N)c1C#N CHEMBL377578 IC50 130.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644619 IC50 130.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccc(F)cc4F)n(C4CCCC4)c3n2)cc1 CHEMBL1946327 IC50 130.0 nM
O=C(N[C@H](CO)c1ccccc1)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1 CHEMBL2420564 IC50 135.0 nM
OCCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425640 IC50 139.0 nM
Fc1ccc(-c2[nH]c(C3CCCNC3)nc2-c2ccncc2)cc1 CHEMBL67874 IC50 140.0 nM
CCC(C)Nc1nnc(Sc2ncc([N+](=O)[O-])s2)s1 CHEMBL599518 IC50 140.0 nM
O=C(Cc1cc(F)cc2ncccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822134 IC50 140.0 nM
CCNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 CHEMBL1946330 IC50 140.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C4CCCCC4)c3n2)cc1 CHEMBL1946337 IC50 140.0 nM
COC(=O)c1c(CN2CCC(S(C)(=O)=O)CC2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204096 IC50 140.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)c(C)nc32)cs1 CHEMBL4859957 IC50 140.0 nM
Cc1cccn2nc(-c3ccccc3)c(-c3ccnc(N[C@H]4CCN(C(=O)c5ccc(NC(=O)/C=C/CN(C)C)cc5)C4)n3)c12 CHEMBL5415188 IC50 142.0 nM
CC(C)C(=O)N[C@H]1CC[C@@H](Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577870 IC50 143.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5396715 IC50 143.9 nM
O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1nccs1 CHEMBL1822154 IC50 145.0 nM
Cc1ccc(NC(=O)c2ccc(F)c(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3355156 IC50 148.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd apparent 148.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NCCO)n2)cc1 CHEMBL218219 IC50 150.0 nM
Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc(Nc3ncnc4ccc(N)cc34)c2)c1 CHEMBL497615 IC50 150.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2cccc(Cl)c2c1 CHEMBL1644637 IC50 150.0 nM
O=c1n(-c2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644641 IC50 150.0 nM
Cc1sc(C(=O)NC2COC2)cc1-n1cc(NC(=O)Nc2c(F)cccc2Cl)cn1 CHEMBL4784092 IC50 150.0 nM
CS(=O)(=O)CCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425636 IC50 151.0 nM
O=C(C1CC1)N1CCC[C@H](Nc2nccc(-n3c(-c4ccc5ccccc5c4)nc4c(F)cc(O)cc43)n2)C1 CHEMBL5430912 IC50 151.0 nM
CC(C)n1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3355174 IC50 158.0 nM
Fc1ccc(-c2nc3sccn3c2-c2ccncc2)cc1 CHEMBL2000508 pKi 158.49 nM
CCc1nccn2c(-c3ccnc(NCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL2001547 pKi 158.49 nM
CN(C)CC(C)(C)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3occn23)n1 CHEMBL1968127 pKi 158.49 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1996500 pKi 158.49 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 158.49 nM
CCOc1nc(NC(=O)Cc2cc(OC)c(Br)cc2OC)cc(N)c1C#N CHEMBL382639 IC50 160.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC3CCC3)n2)cc1 CHEMBL221229 IC50 160.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3ccc(C(=O)O)s3)n2)cc1 CHEMBL218367 IC50 160.0 nM
COCCNc1nnc(Sc2ncc([N+](=O)[O-])s2)s1 CHEMBL611079 IC50 160.0 nM
CC(C)C(=O)N1CCC(Nc2ncc3ccc(=O)n(C(C)C)c3n2)CC1 CHEMBL3577872 IC50 160.0 nM
O=C(Cc1cccc2ncc(C(F)(F)F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822135 IC50 164.0 nM
O=c1n(C2CCN(CC(F)(F)F)CC2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644645 IC50 170.0 nM
COC(=O)c1c(Cc2ccc(C(=O)NCCO)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL2152382 Kd 170.0 nM
CNS(=O)(=O)c1ccc(Cc2c(C(=O)OC)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 CHEMBL2204106 IC50 170.0 nM
N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425652 IC50 170.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 CHEMBL215943 IC50 173.0 nM
CNc1nccc(-c2[nH]c(-c3ccccc3)nc2-c2ccccc2)n1 CHEMBL67633 IC50 175.0 nM
COC(=O)c1c(Cc2ccc(C(=O)NCCO)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL2204094 IC50 176.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL246544 IC50 177.0 nM
COc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425641 IC50 178.0 nM
Nc1nccc(-c2[nH]c(-c3ccccc3)nc2-c2ccccc2)n1 CHEMBL302728 IC50 180.0 nM
CCCCNC(=O)C1CCN(CC(=O)Nc2cc(N)c(C#N)c(OCC)n2)CC1 CHEMBL209669 IC50 180.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NCCCO)n2)cc1 CHEMBL434560 IC50 180.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(S(C)(=O)=O)CC5)cccc43)n2)CC1 CHEMBL2392826 IC50 180.0 nM
O=C([C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1)N1CCOCC1 CHEMBL2425649 IC50 180.0 nM
CCOc1nc(C(=O)NCc2ccccc2)cc(N)c1C#N CHEMBL211195 IC50 190.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2cc(F)ccc2c1 CHEMBL1644632 IC50 190.0 nM
COC(=O)c1c(CN2CCC(S(C)(=O)=O)CC2)c(=O)c2ccc(C)nc2n1-c1ccccc1 CHEMBL2204100 IC50 190.0 nM
O=C(Cn1c(=O)ccc2c(C(F)(F)F)cccc21)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822148 IC50 193.0 nM
OCC(O)COc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425638 IC50 194.0 nM
Fc1ccc(-c2nc[nH]c2-c2ccncc2)cc1 CHEMBL63135 IC50 195.0 nM
O=C1NCCc2[nH]c3c(ccc4cnc(/C=C/c5ccc(CN6CCOCC6)cc5)cc43)c21 CHEMBL1801384 IC50 198.0 nM
O=C(Cc1c(F)cccc1Cl)Nc1onc(-c2ccc(F)cc2)c1-c1ccncn1 CHEMBL3310142 IC50 198.0 nM
Cc1cccc(-c2c(-c3ccncc3)nc(NCC(N)Cc3ccccc3)n(C)c2=O)c1 CHEMBL1971430 pKi 199.53 nM
Cc1cnc(Nc2nc(NC(C)C)ncc2Br)s1 CHEMBL1973013 pKi 199.53 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2cccc(OCC(=O)O)c2)n1 CHEMBL1964902 pKi 199.53 nM
Cc1nccn2c(-c3ccnc(NCC4(O)CC4)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1965589 pKi 199.53 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 199.53 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 199.53 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(CCN)nccn23)n1 CHEMBL1982383 pKi 199.53 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)N3CCC(O)CC3)cc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204110 IC50 200.0 nM
Fc1ccc(-c2[nH]c(C3CCNCC3)nc2-c2ccncc2)cc1 CHEMBL69764 IC50 210.0 nM
COCCNc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL384951 IC50 210.0 nM
O=C(Nc1cnn(-c2cccc(C(=O)Nc3cnn(C4CCNC4)c3)c2)c1)Nc1ccccc1Cl CHEMBL3355178 IC50 210.0 nM
N#CC(c1ccnc(NC2Cc3c[nH]c2n3)n1)c1nc2ccccc2s1 CHEMBL3909478 IC50 210.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-c3cnc4ccccn34)n2)CC1 CHEMBL3655587 IC50 213.8 nM
COC(=O)c1c(Cc2ccc(S(=O)(=O)CCO)cc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204111 IC50 219.0 nM
N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1 CHEMBL1788116 IC50 220.0 nM
N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1 CHEMBL191384 IC50 220.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644622 IC50 220.0 nM
COC(=O)c1c(Cc2ccc(S(C)(=O)=O)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL2204093 IC50 220.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N[C@@H](C)C(C)(C)C)c2n1 CHEMBL3809829 IC50 220.0 nM
N#CC(c1ccnc(NCCc2cccnc2)n1)c1nc2ccccc2s1 CHEMBL406703 IC50 220.0 nM
C/C=C/c1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL221126 IC50 230.0 nM
Cc1n[nH]c(-c2c(C)csc2NC(=O)Cc2cccc3nccnc23)n1 CHEMBL1682009 IC50 230.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 230.0 nM
CC(=O)N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425651 IC50 230.0 nM
NC(=O)N1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCN(C(=O)C5CC5)C4)n3)c2C1 CHEMBL5406554 IC50 230.0 nM
COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(OCCO)n2)c1 CHEMBL210462 IC50 240.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(/C=C/CCO)n2)cc1 CHEMBL218141 IC50 240.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3cccc(O)c3)n2)cc1 CHEMBL221745 IC50 240.0 nM
CN(C)CCOc1ccc(/C=C/c2cc(-c3cc4c(=O)[nH]cnc4[nH]3)ccn2)cc1 CHEMBL461140 IC50 240.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 240.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 240.0 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@H]4CC[C@H](N)CC4)c3n2)cc1 CHEMBL1946339 IC50 240.0 nM
CC(C)n1c(=O)ccc2cnc(NC3CCOCC3)nc21 CHEMBL3577862 IC50 241.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@H]2CCCCN(C(=O)C3CC3)C2)n1 CHEMBL5428554 IC50 241.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245725 IC50 245.0 nM
CS(=O)(=O)NCCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2425637 IC50 246.0 nM
CCNC(=O)N1CCC(Nc2ncc(C)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL245724 IC50 250.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644620 IC50 250.0 nM
O[C@H]1CC[C@H](Nc2nccc(-c3cnc4ccccn34)n2)CC1 CHEMBL2425648 IC50 250.0 nM
N#CC(c1ccnc(OCc2ccccc2)n1)c1nc2ccccc2s1 CHEMBL3899711 IC50 250.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 251.19 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 251.19 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 251.19 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 251.19 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 251.19 nM
CCOc1nc(NC(=O)Cc2ccccc2OC)cc(N)c1C#N CHEMBL210655 IC50 260.0 nM
C/C=C\c1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL218657 IC50 260.0 nM
C[C@H](Nc1cc(-c2sc(C3CCN(C)CC3)nc2-c2ccc(F)cc2)ccn1)c1ccccc1 CHEMBL2111784 IC50 261.0 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 262.0 nM
CNC(=O)CN1CCC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 CHEMBL245334 IC50 267.0 nM
N#CCc1cnc(-c2ccc3occc3c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 CHEMBL5396572 IC50 267.7 nM
O=C1NCCc2[nH]c3c(ccc4cnc(-c5cccc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801387 IC50 269.0 nM
COCCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N CHEMBL211009 IC50 270.0 nM
O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1 CHEMBL1288100 IC50 270.0 nM
CCOc1nc(NC(=O)Cc2ccc(OC)cc2)cc(N)c1C#N CHEMBL426134 IC50 274.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 280.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)C5)cccc43)n2)CC1 CHEMBL2392830 IC50 280.0 nM
COc1ccc(C(=O)O/N=C2/c3ccccc3-c3nc4ccccc4nc32)cc1OC CHEMBL3393603 Kd 280.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3cnc4ccccn34)n2)CC1 CHEMBL246543 IC50 281.0 nM
Cc1ccc(-c2ncn(-c3ccc(Nc4nccc(-c5cccc(N6CCOCC6)c5)n4)cc3)n2)cn1 CHEMBL2144409 IC50 283.0 nM
N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(Nc2cccc(C(=O)C3CC3)c2)n1 CHEMBL5419748 IC50 287.3 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(NC3CCCC3)n2)cc1 CHEMBL375795 IC50 290.0 nM
CCCNc1nnc(Sc2ncc([N+](=O)[O-])s2)s1 CHEMBL609039 IC50 290.0 nM
COC(=O)c1c(CN2CCC(S(C)(=O)=O)CC2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1 CHEMBL2204101 IC50 290.0 nM
O=C(O/N=C1/c2ccccc2-c2nc3ccccc3nc21)c1ccco1 CHEMBL3393602 Kd 290.0 nM
CC(C)(O)c1cccn2c(-c3ccnc(N[C@H]4CC[C@H](CS(C)(=O)=O)CC4)n3)cnc12 CHEMBL3655578 IC50 294.9 nM
C[C@@H](Nc1nccc(-c2[nH]c(C3CCNCC3)nc2-c2cccc(C(F)(F)F)c2)n1)c1ccccc1 CHEMBL446404 IC50 295.0 nM
C[C@@H](Nc1nccc(-c2c(-c3cccc(C(F)(F)F)c3)nc(C3CCNCC3)n2C)n1)c1ccccc1 CHEMBL307435 IC50 300.0 nM
C#Cc1c(N)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)nc1OCC CHEMBL383994 IC50 300.0 nM
C#C/C=C/c1c(N)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)nc1OCC CHEMBL221128 IC50 300.0 nM
COc1ccc(Oc2nccc(C(C#N)c3nc4ccccc4s3)n2)cc1 CHEMBL3947385 IC50 300.0 nM
CC(C)Nc1nccc(-c2c(C3CC3)nn3ccccc23)n1 CHEMBL4777781 IC50 300.0 nM
Cc1nc2c(F)cc(-c3nc(Nc4ccc5c(n4)CCN(CCN(C)C)C5)ncc3F)cc2n1C(C)C CHEMBL4448494 IC50 305.0 nM
CCOc1nc(NC(=O)Cc2cccc(OC)c2)cc(N)c1C#N CHEMBL209291 IC50 310.0 nM
O=C(Nc1cnn(-c2cccc(C(=O)NCC3CCNCC3)c2)c1)Nc1ccccc1Cl CHEMBL3355181 IC50 311.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1 CHEMBL3991932 Kd apparent 312.0 nM
N#Cc1c(NC(=O)c2cccc3ccccc23)sc2c1CCCC2 CHEMBL233001 pIC50 316.23 nM
N#Cc1c(NC(=O)c2cccc3ccccc23)sc2c1CCCN2C(=O)C1CC1 CHEMBL232601 pIC50 316.23 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 316.23 nM
Cn1nc(C(F)(F)F)c2c(=O)c3cc(Cl)ccc3n(O)c21 CHEMBL207400 pKi 316.23 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 316.23 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(C(=O)NCCOCCO)c2)n1 CHEMBL1978271 pKi 316.23 nM
CNc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL2007372 pKi 316.23 nM
CC(C)C(CO)NC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1971223 pKi 316.23 nM
N#CC1=C(c2ccccc2)CC(c2ccc(Cl)cc2)C(C(=O)c2ccccc2)C1=O CHEMBL1978371 pKi 316.23 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 316.23 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 316.23 nM
CC(C)C(C)Nc1ncc(Cl)c(Nc2nccs2)n1 CHEMBL1993374 pKi 316.23 nM
C[C@H](CO)Nc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL220696 IC50 320.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 320.0 nM
O=c1n(C2CCOC2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644640 IC50 320.0 nM
NC(=O)c1ccccc1Nc1ccnc(Nc2ccc(N3CCOCC3)cc2)c1 CHEMBL3220479 IC50 329.0 nM
COc1ccc2c(c1)OCC(C(=O)NC(=O)N(CC(=O)NCCCCCCNC(=O)c1ccc(-c3n[nH]c4ccccc34)cc1)CC(C)C)O2 CHEMBL3393604 IC50 336.0 nM
O=C(Cc1cc(C(F)(F)F)cc2ncccc12)Nc1scc(Br)c1-c1ncn[nH]1 CHEMBL1822136 IC50 337.0 nM
Cn1cc(-c2c[nH]c3ncc([C@H]4CC[C@H](N5CCCOCC5)CC4)cc23)cn1 CHEMBL3393597 IC50 339.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3cccnc3)n2)cc1 CHEMBL220811 IC50 340.0 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 Kd apparent 340.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644621 IC50 350.0 nM
O[C@H]1CC[C@H](Nc2nccc(-n3ncc4ccccc43)n2)CC1 CHEMBL2425645 IC50 350.0 nM
CCOc1nc(NC(=O)Cc2ccc(C)cc2)cc(N)c1C#N CHEMBL209192 IC50 360.0 nM
CNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 CHEMBL1946329 IC50 360.0 nM
O[C@H]1CC[C@H](Nc2nccc(-n3ccc4ccccc43)n2)CC1 CHEMBL2425646 IC50 360.0 nM
O/N=C1/c2ccccc2-c2nc3ccccc3nc21 CHEMBL3393601 Kd 360.0 nM
O/N=C1/c2ccccc2-c2nc3ncccc3nc21 CHEMBL4593099 Kd 360.0 nM
O/N=C1\c2ccccc2-c2nc3ccccc3nc21 CHEMBL3759098 Kd 360.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 364.0 nM
CC(C)(O)c1cccn2c(-c3ccnc(N[C@H]4CC[C@H](C(=O)N5CCC(O)CC5)CC4)n3)cnc12 CHEMBL3655579 IC50 369.1 nM
CC(C)COc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL218658 IC50 370.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 370.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 379.5 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2cccc(F)c2c1 CHEMBL1644635 IC50 380.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3ccsc3)n2)cc1 CHEMBL219112 IC50 390.0 nM
O=c1[nH]nc(-c2ccnc(NC3CC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644623 IC50 390.0 nM
c1ccc2c(c1)nnn2-c1ccnc(NC2CCCCC2)n1 CHEMBL2425656 IC50 390.0 nM
COCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3cnccn23)n1 CHEMBL1969372 pKi 398.11 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 398.11 nM
O=C(NCc1ccc(Cl)cc1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL1967094 pKi 398.11 nM
CC(C)n1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)cc21 CHEMBL1969126 pKi 398.11 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 398.11 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 398.11 nM
COc1ccc(-n2ccc3cnc(Nc4cc(OC)c(OC)c(OC)c4)nc32)cc1 CHEMBL1975927 pKi 398.11 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 398.11 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 398.11 nM
CCOc1nc(NC(C)=O)cc(N)c1C#N CHEMBL208637 pKi 398.11 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 398.11 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 398.11 nM
CSc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL17370 pKi 398.11 nM
O=C([C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1)N1CCCC1 CHEMBL2425650 IC50 400.0 nM
COC(=O)c1c(C)csc1NC(=O)Cc1cccc2ncccc12 CHEMBL1682004 IC50 409.0 nM
CNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)cnc32)cs1 CHEMBL4851793 IC50 414.0 nM
O=C1NCCc2[nH]c3c(ccc4cnc(-c5cncc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801388 IC50 418.0 nM
Cc1ccc(CNC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cn1 CHEMBL3355168 IC50 428.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(/C=C/C(=O)O)n2)cc1 CHEMBL434368 IC50 430.0 nM
CCn1c(Nc2ccccc2F)nc2cnc(Nc3ccc(OC)cc3)nc21 CHEMBL1946335 IC50 430.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 430.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C4CCOCC4)c3n2)CC1 CHEMBL3577878 IC50 434.0 nM
Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Cl)cc2)c1 CHEMBL568875 IC50 440.0 nM
O=C(Nc1cc(-c2n[nH]c(=O)n2-c2ccc3ccccc3c2)ccn1)C1CC1 CHEMBL1644630 IC50 440.0 nM
COc1ccc(Oc2nc(C(=O)NCc3ccc(S(C)(=O)=O)cc3)cc(N)c2C#N)cc1 CHEMBL218419 IC50 450.0 nM
COc1nccc(C(C#N)c2nc3ccccc3s2)n1 CHEMBL3947134 IC50 450.0 nM
CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C)c3n2)CC1 CHEMBL3577876 IC50 463.0 nM
CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1 CHEMBL378931 IC50 470.0 nM
O=[N+]([O-])c1cnc(Sc2nnc(NCC3CCCO3)s2)s1 CHEMBL601476 IC50 470.0 nM
O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1 CHEMBL1288160 IC50 470.0 nM
O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644624 IC50 470.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3ncc(Cl)c(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 CHEMBL5406812 IC50 483.0 nM
O=[N+]([O-])c1cnc(Sc2nnc(O)n2-c2ccc3c(c2)OCCO3)s1 CHEMBL508280 IC50 500.0 nM
N#CC(c1ccnc(Cl)n1)c1nc2ccccc2s1 CHEMBL1991853 IC50 500.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 501.19 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 501.19 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 501.19 nM
CC(=O)Nc1cc(N)c(C#N)c(-c2ccsc2)n1 CHEMBL2006567 pKi 501.19 nM
OCCCn1cnc(-c2ccccc2)c1-c1ccncc1 CHEMBL2002373 pKi 501.19 nM
COc1cc(Nc2nccc(Nc3cc(C4CCCCC4)no3)n2)cc(OC)c1OC CHEMBL1984711 pKi 501.19 nM
Fc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL316264 pKi 501.19 nM
Cc1nn(-c2ccccc2)c2c1c(=O)c1cc(Cl)ccc1n2O CHEMBL379835 pKi 501.19 nM
Nc1cc(-c2n[nH]c(=S)n2-c2ccc3ccccc3c2)ccn1 CHEMBL1784649 IC50 504.0 nM
COC(=O)c1c(CN2CCN(S(C)(=O)=O)CC2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204095 IC50 507.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 509.0 nM
CCNC(=O)N1CCC(Nc2nccc(-n3ccc4ccccc43)n2)CC1 CHEMBL392613 IC50 512.0 nM
N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(N3CCC(F)(F)C3)n2)c1 CHEMBL3393333 IC50 514.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 520.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3ccoc3)n2)cc1 CHEMBL387253 IC50 530.0 nM
O=c1n(C2CCNCC2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644643 IC50 530.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4C)ccn3)cc2)c1 CHEMBL4082278 IC50 531.7 nM
COC(=O)c1c(CN2CC[C@H](S(C)(=O)=O)C2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204099 IC50 535.0 nM
COc1ccc(-c2cc3c(ccc4c5c([nH]c43)CN(C)NC5=O)cn2)cc1 CHEMBL1801316 IC50 547.0 nM
Cc1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4ccccc4Cl)cn3)c2)cc(C)n1 CHEMBL3355166 IC50 561.0 nM
Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Nc3ncnc4ccc(N)cc34)cc2)c1 CHEMBL497033 IC50 570.0 nM
Nc1cccc2ccc(-n3c(-c4ccnc(NC5CCOCC5)c4)n[nH]c3=O)cc12 CHEMBL1644636 IC50 570.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1F CHEMBL3220465 IC50 590.0 nM
COc1cccc(-c2nc(C(=O)NCc3ccc(S(C)(=O)=O)cc3)cc(N)c2C#N)c1 CHEMBL221252 IC50 600.0 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(C(=O)N6CC7(CN(C)C7)C6)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5085753 IC50 602.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(-n3ccnn3)cc2)ncc1C(F)(F)F CHEMBL3220471 IC50 603.0 nM
NC(=O)c1ccccc1Nc1ccnc(Nc2ccc(-n3ccnn3)cc2)c1 CHEMBL3220486 IC50 603.0 nM
CCOc1nc(NC(=O)Cc2ccc(Cl)cc2)cc(N)c1C#N CHEMBL209292 IC50 610.0 nM
CCOc1nc(C(=O)NC)cc(N)c1C#N CHEMBL211605 IC50 610.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(OCC3CCCC3)n2)cc1 CHEMBL374431 IC50 610.0 nM
COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCCC2)cc1 CHEMBL1682000 IC50 613.0 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 CHEMBL494072 IC50 629.0 nM
NC(=S)N/N=C1\NC(=O)/C(=C/c2ccc3c(c2)OCO3)S1 CHEMBL1969923 IC50 630.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 630.96 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 630.96 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 630.96 nM
C=CCc1cccc2c(=NO)cc(-c3ccccc3)oc12 CHEMBL1977749 pKi 630.96 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 630.96 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCC(O)CC2)n1 CHEMBL256835 pKi 630.96 nM
Brc1ccc2[nH]nc(-c3ccccc3)c2c1 CHEMBL1994074 pKi 630.96 nM
CCOc1nc(NC(=O)CN2CCC(O)CC2)cc(N)c1C#N CHEMBL209770 IC50 640.0 nM
NC(=O)c1ccsc1NC(=O)Cc1csc2ccccc12 CHEMBL1767254 Kd 640.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 640.0 nM
COCCOc1cncc(-c2cc3c(ccc4c5c([nH]c43)CCNC5=O)cn2)c1 CHEMBL1614995 IC50 649.0 nM
O=C(NCc1ccc(S(=O)(=O)N2CCC(n3nnc4ccccc43)CC2)s1)c1ccc(Cl)cc1 CHEMBL383955 IC50 650.0 nM
O=c1[nH]nc(-c2ccnc(Nc3nccs3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644627 IC50 650.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCCCC5)cccc43)n2)CC1 CHEMBL2392829 IC50 650.0 nM
O[C@H]1CC[C@H](Nc2nccc(-c3n[nH]c4ccccc34)n2)CC1 CHEMBL2425644 IC50 650.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3ccncc3)n2)cc1 CHEMBL374447 IC50 660.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 670.0 nM
C[C@H](Nc1nccc(-c2c(-c3cccc(C(F)(F)F)c3)nc(C3CCNCC3)n2C)n1)c1ccccc1 CHEMBL305178 IC50 675.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3ccsc3CO)n2)cc1 CHEMBL220547 IC50 680.0 nM
CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(-c4ccc5nc(C)oc5c4)c[nH]c3n2)c(OC)c1 CHEMBL4062218 IC50 680.0 nM
CCCCC(=O)Nc1cc(N)c(C#N)c(OCC)n1 CHEMBL378499 IC50 690.0 nM
CCNC(=O)N1CCC(Nc2nccc(-c3c(C(C)C)[nH]c4ccccc34)n2)CC1 CHEMBL391794 IC50 698.0 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(/C=C/c5cccc(CCN6CCOCC6)c5)cc43)c21 CHEMBL1801392 IC50 700.0 nM
Cn1nc(-c2ccc3c(c2)OCO3)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL2151190 IC50 700.0 nM
COC(=O)c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc21 CHEMBL1682005 IC50 703.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-n3ccc4ccccc43)n2)CC1 CHEMBL245925 IC50 709.0 nM
O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1nnc[nH]1 CHEMBL1288099 IC50 710.0 nM
O[C@H]1CC[C@H](Nc2nccc(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL2425642 IC50 720.0 nM
COc1ccc(CNc2nccc(-c3[nH]c(C4CCNCC4)nc3-c3cccc(C(F)(F)F)c3)n2)cc1 CHEMBL307980 IC50 735.0 nM
CCOC(=O)CO/N=C1\c2ccccc2-c2nc3ccccc3nc21 CHEMBL4582239 Kd 735.0 nM
COc1ccc(OC)c(CC(=O)Nc2cc(N)c(C#N)c(OCCS(C)(=O)=O)n2)c1 CHEMBL380152 IC50 740.0 nM
CCCN(CCO)CC(=O)Nc1cc(N)c(C#N)c(OCC)n1 CHEMBL383308 IC50 740.0 nM
CCOc1nc(NC(=O)Cc2ccccc2C)cc(N)c1C#N CHEMBL208558 IC50 740.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 745.0 nM
COC(=O)c1c(C)csc1NC(=O)Cc1cccc2nccnc12 CHEMBL1682003 IC50 765.0 nM
CCOc1nc(NC(=O)Cc2ccccc2)cc(N)c1C#N CHEMBL210861 IC50 770.0 nM
O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2cc(Br)ccc2c1 CHEMBL1644634 IC50 780.0 nM
CCOc1nc(NC(=O)Cc2cccc(C)c2)cc(N)c1C#N CHEMBL208447 IC50 790.0 nM
COc1cc2c(cc1Cl)C(c1ccc(Cl)c(Cl)c1)=NCC2 CHEMBL1087421 pIC50 794.33 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 794.33 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 pKi 794.33 nM
Cc1cc(O)ccc1-n1c2cc(Cl)ccc2c(=O)c2c(N)nc(N)nc21 CHEMBL1995592 pKi 794.33 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 794.33 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 794.33 nM
O=C(Nc1ccc(CO)cc1)c1cnn2c(-c3ccccc3)ccnc12 CHEMBL1974363 pKi 794.33 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cccc(F)c3F)cc12 CHEMBL1985406 pKi 794.33 nM
OCCCn1cnc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL2004871 pKi 794.33 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2ccc(OCC(=O)O)cc2)n1 CHEMBL2005699 pKi 794.33 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 794.33 nM
O=C(NN=Cc1ccc(Sc2nc3ccccc3[nH]2)o1)c1cccc([N+](=O)[O-])c1 CHEMBL1992555 pKi 794.33 nM
Cc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)n[nH]c12 CHEMBL1973937 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 794.33 nM
Clc1ccc(-c2n[nH]cc2-c2ccncn2)cc1Cl CHEMBL1984191 pKi 794.33 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 794.33 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 794.33 nM
COc1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1 CHEMBL1946324 IC50 800.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc3c(c2)OCO3)ncc1C(F)(F)F CHEMBL3220474 IC50 806.0 nM
NC(=O)c1ccccc1Nc1ccnc(Nc2ccc3c(c2)OCO3)c1 CHEMBL3220489 IC50 806.0 nM
O=C(Nc1cnn(-c2csc(C(=O)NCC3CCOCC3)c2)c1)Nc1ccccc1Cl CHEMBL4744992 IC50 810.0 nM
C[C@H](Nc1nccc(-c2cc(N3CCOCC3)nnc2-c2cccc(C(F)(F)F)c2)n1)c1ccccc1 CHEMBL162295 IC50 820.0 nM
COc1ccc(CC(=O)Nc2scc(C)c2-c2nc(C)n[nH]2)cc1 CHEMBL1682006 IC50 824.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3cccc(Cl)c3)n2)cc1 CHEMBL222008 IC50 840.0 nM
Cc1ccc2nc3c(nc2c1)-c1ccccc1/C3=N/O CHEMBL4521282 Kd 840.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 850.0 nM
CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(-c3cncnc3)n2)cc1 CHEMBL221075 IC50 860.0 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)c(C)c2)ncc1C(F)(F)F CHEMBL3220477 IC50 860.0 nM
Cc1cc(Nc2cc(Nc3ccccc3C(N)=O)ccn2)ccc1N1CCOCC1 CHEMBL3220492 IC50 860.0 nM
COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cnccc12 CHEMBL1681791 IC50 863.0 nM
c1ccc2cc(-c3[nH]ncc3-c3ccncc3)ccc2c1 CHEMBL1784666 IC50 864.0 nM
CCOc1nc(NC(=O)Cc2cccc(Cl)c2)cc(N)c1C#N CHEMBL210586 IC50 900.0 nM
COC(=O)c1c(CN2CCOCC2)c(=O)c2ccc(F)cc2n1-c1ccccc1 CHEMBL2204097 IC50 900.0 nM
FC(F)(F)c1cccc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)c1 CHEMBL67658 IC50 910.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3301612 Kd apparent 915.0 nM
CCOC(=O)c1c(C#N)csc1NC(=O)Cc1ccc(OC)cc1 CHEMBL1681996 IC50 930.0 nM
O=c1[nH]cnc2[nH]c(-c3ccnc(/C=C/c4ccc(CN5CCOCC5)cc4)c3)cc12 CHEMBL461139 IC50 950.0 nM
O=c1[nH]nc(-c2ccnc(Nc3cccnc3)c2)n1-c1ccc2ccccc2c1 CHEMBL1644626 IC50 950.0 nM
COC(=O)c1c(Cc2ccccc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL2204105 IC50 960.0 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C(N)=O CHEMBL221179 IC50 969.0 nM
CSc1nccc(C(C#N)c2nc3ccccc3s2)n1 CHEMBL3911431 IC50 970.0 nM
CNC(=O)Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2c1 CHEMBL5418625 IC50 973.0 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(/C=C/c5ccc(CN6CCOCC6)cc5)cc43)c21 CHEMBL1801391 IC50 980.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 Kd apparent 980.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 986.0 nM