NC(=O)c1ccc(N(C(N)=O)c2c(F)cccc2F)nc1-c1ccc(F)cc1F CHEMBL1090090 Kd apparent 0.3 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNC2)CNC3=O)ccn1)c1ccc2ccccc2c1 CHEMBL1933189 EC50 0.62 nM
Cc1ccc(C(=O)Nc2cc(-c3cc4c([nH]3)C3(CCNC3)CNC4=O)ccn2)cc1C CHEMBL1933188 EC50 0.71 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)ccn1)c1ccc2ccccc2c1 CHEMBL1933164 EC50 0.72 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(NC(=O)c4cccc5ccccc45)c3)cc21 CHEMBL1933166 EC50 0.96 nM
C[C@@H]1CNc2c(sc3ccc4ncccc4c23)C(=O)N1 CHEMBL561334 IC50 1.0 nM
O=C1NCCc2[nH]c3c(ccc4cnc(/C=C/c5ccc(CN6CCOCC6)cc5)cc43)c21 CHEMBL1801384 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)ccn2)cc1C CHEMBL1933162 EC50 1.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4cccnc4)n3)cc21 CHEMBL1779362 EC50 1.1 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)ccn1)c1cccc(F)c1 CHEMBL1933171 EC50 1.1 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNC2)CNC3=O)ccn1)c1ccc(F)cc1 CHEMBL1933190 EC50 1.3 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)ccn1)c1ccccn1 CHEMBL1933176 EC50 1.4 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)ccn1)c1cccc(OC(F)(F)F)c1 CHEMBL1933173 EC50 1.5 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNC2)CNC3=O)ccn1)c1cccc(OC(F)(F)F)c1 CHEMBL1933192 EC50 1.6 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)ccn1)c1ccc(C(F)(F)F)cc1 CHEMBL1933175 EC50 1.6 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)ccn1)c1ccc(F)cc1 CHEMBL1933168 EC50 1.6 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4cnc(NC5CCCC5)nc4)n3)cc21 CHEMBL1779367 EC50 1.7 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNC2)CNC3=O)ccn1)c1cccc(F)c1 CHEMBL1933191 EC50 1.9 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cncnc2)c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL2385548 IC50 1.9 nM
CC(C)(C)CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)n2)CC1 CHEMBL257834 IC50 2.0 nM
CC(C)(C)CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C(C)(C)CNC5=O)n2)CC1 CHEMBL403154 IC50 2.0 nM
CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)n2)CC1 CHEMBL258045 IC50 2.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(Cl)ccc4c23)C(=O)N1 CHEMBL556392 IC50 2.0 nM
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 CHEMBL1231206 IC50 2.0 nM
Nc1ncc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)cn1 CHEMBL1779366 EC50 2.1 nM
Cc1ccc(C(=O)Nc2cc(-c3cc4c([nH]3)C3(CCN(C)CC3)CNC4=O)ccn2)cc1C CHEMBL1933169 EC50 2.3 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1ccc(F)cc1 CHEMBL1933181 EC50 2.4 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1cc(F)cc(F)c1 CHEMBL1933186 EC50 2.5 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1ccc2ccccc2c1 CHEMBL1933179 EC50 2.5 nM
CN1CCC2(CC1)CNC(=O)c1cc(-c3ccnc(NC(=O)c4cccc(F)c4)c3)[nH]c12 CHEMBL1933172 EC50 2.5 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)ccn1)c1ccncc1 CHEMBL1933177 EC50 2.6 nM
CN1CCC2(CC1)CNC(=O)c1cc(-c3ccnc(NC(=O)c4ccc5ccccc5c4)c3)[nH]c12 CHEMBL1933170 EC50 2.6 nM
CN1CCC2(CC1)CNC(=O)c1cc(-c3ccnc(NC(=O)c4cccc(OC(F)(F)F)c4)c3)[nH]c12 CHEMBL1933174 EC50 2.7 nM
N#Cc1ccc(-c2cc3c(o2)-c2nccn2-c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL1938685 IC50 2.9 nM
O=C(Nc1nc(C(=O)NC2CCN(Cc3ccccc3)CC2)cs1)c1ccc2cc3n(c2c1)C1(CCC1)CNC3=O CHEMBL403258 IC50 3.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCN(CC(C)(C)C)CC5)cs4)cc3n21 CHEMBL256194 IC50 3.0 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cncnc2)c2ccc(C4CCNCC4)cc2C3)cc1 CHEMBL2385549 IC50 3.0 nM
Cc1ccc(C(=O)Nc2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)cc1C CHEMBL1933161 EC50 3.1 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 3.162 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1cccc(C(F)(F)F)c1 CHEMBL1933187 EC50 3.3 nM
CCC(=O)Nc1ccc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)cn1 CHEMBL1779365 EC50 3.6 nM
N#Cc1ccc(-c2cc3c(o2)-c2nncn2-c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL1938687 IC50 3.8 nM
CC(C)CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C(C)CNC5=O)n2)CC1 CHEMBL255991 IC50 4.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4ccc5c(c4)OCO5)n3)cc21 CHEMBL1738702 EC50 4.0 nM
CN1CCC2(CC1)CNC(=O)c1c2[nH]c2c1CCc1cnc(-c3ccccc3F)cc1-2 CHEMBL1801296 IC50 4.0 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCNC2)CNC3=O)ccn1)c1ccccn1 CHEMBL1933193 EC50 4.1 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1ccccn1 CHEMBL1933185 EC50 4.2 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O CHEMBL1089865 IC50 4.3 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4cc(Cl)cc(Cl)c4)n3)cc21 CHEMBL1779360 EC50 4.5 nM
COc1cncc(-c2ccccc2CN2C(=O)c3oc(-c4ccc(C#N)cc4)cc3Cc3cc(N4CCNCC4)ccc32)c1 CHEMBL2385542 IC50 4.9 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCN(Cc6ccccc6)CC5)cs4)cc3n21 CHEMBL429504 IC50 5.0 nM
CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C(C)(C)CNC5=O)n2)CC1 CHEMBL270148 IC50 5.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCN(C)CC5)cs4)cc3n21 CHEMBL271309 IC50 5.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(-c5cccnc5)ccc4c23)C(=O)N1 CHEMBL560075 IC50 5.0 nM
Cc1ccncc1-c1ccc2c(ccc3sc4c(c32)NC[C@@H](C)NC4=O)n1 CHEMBL549915 IC50 5.0 nM
COc1ccc2sc3c(c2c1)NC[C@@H](CN)NC3=O CHEMBL555205 IC50 5.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(-c5cncc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801381 IC50 5.0 nM
COCCOc1cncc(-c2cc3c(ccc4c5c([nH]c43)CNC5=O)cn2)c1 CHEMBL1801382 IC50 5.0 nM
O=C1NCCc2[nH]c3c(ccc4cnc(/C=C/c5cccc(CCN6CCOCC6)c5)cc43)c21 CHEMBL1801385 IC50 5.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4ccc5ccccc5c4)n3)cc21 CHEMBL1779359 EC50 5.1 nM
O=C1NCC2(CCCNC2)c2[nH]c(-c3ccnc(NC(=O)c4cccc5ccccc45)c3)cc21 CHEMBL1933180 EC50 5.1 nM
O=C(Nc1nccc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)n1)c1ccc2ccccc2c1 CHEMBL1933163 EC50 5.1 nM
Cc1ccc(C(=O)Nc2cc(-c3cc4c([nH]3)C3(CCCNC3)CNC4=O)ccn2)cc1C CHEMBL1933178 EC50 5.5 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3ccc(F)cc3F)c2n(C)c1=O CHEMBL1091199 IC50 5.7 nM
O=C1c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc2N1Cc1ccccc1-c1cncnc1 CHEMBL2385547 IC50 5.7 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4cc5ccccc5o4)n3)cc21 CHEMBL1779352 EC50 5.9 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)n3)cc21 CHEMBL1779361 EC50 6.0 nM
COCCOc1cncc(-c2ncc3c(n2)-c2[nH]c4c(c2CC3)C(=O)NCC42CN(C)C2)c1 CHEMBL1801304 IC50 6.0 nM
CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4cccc(F)c4)nc3-2)C1 CHEMBL1801305 IC50 6.0 nM
N#Cc1ccc(-c2ccc(C3=NOC(c4ccccc4-c4cncnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036616 IC50 6.0 nM
CC(C)(C)c1ccc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)cc1 CHEMBL1779358 EC50 6.2 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1cccc(F)c1 CHEMBL1933182 EC50 6.2 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 6.31 nM
CNCCOc1ccccc1C(C)(C)Nc1nccn(-c2cc(C(=O)NC3CC3)ccc2C)c1=O CHEMBL4792347 pIC50 6.31 nM
Cc1cnc(-c2ccnc(C(C)(C)O)n2)cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O CHEMBL3902121 IC50 6.4 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21 CHEMBL1092754 IC50 6.5 nM
O=C1NC[C@@]2(CCCNC2)c2[nH]c(-c3ccnc(-c4cccnc4)n3)cc21 CHEMBL1779488 EC50 6.5 nM
COc1ccncc1-c1ccccc1CN1C(=O)c2oc(-c3ccc(C#N)cc3)cc2Cc2cc(N3CCNCC3)ccc21 CHEMBL2385546 IC50 6.8 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4ccc(C(F)(F)F)cc4)n3)cc21 CHEMBL1779357 EC50 6.9 nM
COc1cncc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)c1 CHEMBL1779363 EC50 6.9 nM
COCCCOc1ccc(-c2nccc(-c3cc4c([nH]3)[C@]3(CCCNC3)CNC4=O)n2)cn1 CHEMBL1779485 EC50 6.9 nM
CCN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C(C)CNC5=O)n2)CC1 CHEMBL256196 IC50 7.0 nM
Cn1c(=O)c(-c2cc(C(=O)NC3CC3)ccc2Cl)cc2cnn(-c3c(F)cccc3F)c21 CHEMBL1091928 IC50 7.0 nM
CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccc(F)nc4)nc3-2)C1 CHEMBL1801307 IC50 7.0 nM
Clc1ccc(-c2cc3c(o2)-c2nccn2-c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL1938684 IC50 7.0 nM
O=C1NC[C@@]2(CCCNC2)c2[nH]c(-c3ccnc(-c4ccc5c(c4)OCO5)n3)cc21 CHEMBL1779372 EC50 7.4 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)c(Cl)c3)o2)cc1 CHEMBL3314153 IC50 7.7 nM
O=C(NCc1ccccc1)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL388530 IC50 8.0 nM
O=C(NC1CCCC1)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL388853 IC50 8.0 nM
O=C1NCCc2[nH]c3c(c21)CCc1cnc(-c2cccc(F)c2)cc1-3 CHEMBL1801274 IC50 8.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(/C=C/c5ccc(CN6CCOCC6)cc5)cc43)c21 CHEMBL1801374 IC50 8.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3ccc(C#N)cc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940645 IC50 8.0 nM
COc1ccncc1-c1ccccc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL1940652 IC50 8.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4cccc(F)c4)n3)cc21 CHEMBL1779350 EC50 8.3 nM
COc1ncccc1-c1ccccc1CN1C(=O)c2oc(-c3ccc(C#N)cc3)cc2Cc2cc(N3CCNCC3)ccc21 CHEMBL2385545 IC50 8.4 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 IC50 8.5 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cncnc2)c2ccc(C4CCNCC4)cc2C3(F)F)cc1 CHEMBL2385550 IC50 8.9 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCN(Cc6ccccc6)CC5)cs4)cc3n21 CHEMBL403286 IC50 9.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(-c5ccccc5)ccc4c23)C(=O)N1 CHEMBL564076 IC50 9.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3ccccc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940518 IC50 9.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3cccnc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940648 IC50 9.0 nM
COc1ccncc1-c1ncccc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL1940658 IC50 9.0 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1ccc(C(F)(F)F)cc1 CHEMBL1933184 EC50 9.1 nM
Cc1cnc2n1-c1ccc(N3CCNCC3)cc1Cc1cc(-c3ccc(Cl)cc3)oc1-2 CHEMBL1938689 IC50 9.2 nM
COc1cncc(-c2nccc(-c3cc4c([nH]3)[C@]3(CCCNC3)CNC4=O)n2)c1 CHEMBL1779374 EC50 9.3 nM
Clc1ccc(-c2cc3c(o2)-c2nncn2-c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL1938686 IC50 9.3 nM
CC(=O)c1ccc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)cc1 CHEMBL1779346 EC50 9.8 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NC5CCN(C)CC5)cs4)cc3c21 CHEMBL246301 IC50 10.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4ccc5c(c4)OCCCO5)n3)cc21 CHEMBL1779347 EC50 10.0 nM
COCCOc1cncc(-c2cc3c(ccc4c5c([nH]c43)CCNC5=O)cn2)c1 CHEMBL1614995 IC50 10.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(/C=C/c5ccccc5)cc43)c21 CHEMBL1801373 IC50 10.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(/C=C/c5cccc(CCN6CCOCC6)c5)cc43)c21 CHEMBL1801375 IC50 10.0 nM
O=C1NCCc2[nH]c3c(ccc4cnc(-c5cncc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801388 IC50 10.0 nM
CC(=O)c1cccc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)c1 CHEMBL1779355 EC50 11.0 nM
O=C1NCC2(CCCNC2)c2[nH]c(-c3ccnc(-c4cc5ccccc5o4)n3)cc21 CHEMBL1779368 EC50 11.0 nM
O=C(Nc1cc(-c2cc3c([nH]2)C2(CCCNC2)CNC3=O)ccn1)c1cccc(OC(F)(F)F)c1 CHEMBL1933183 EC50 11.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCOCC5)cs4)cc3n21 CHEMBL272072 IC50 12.0 nM
COc1ccc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NC2(CNC2)C3)cc1 CHEMBL1801294 IC50 12.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3ccccc3F)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940521 IC50 12.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3ccncc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940524 IC50 12.0 nM
COc1cccc(-c2ccccc2CN(C(=O)c2ccc(-c3ccc(C#N)cc3)o2)c2ccc(N3CCNCC3)cc2)c1 CHEMBL1940647 IC50 12.0 nM
COc1ccccc1-c1ncccc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL1940657 IC50 12.0 nM
C=CCN1C(=O)c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc21 CHEMBL2385532 IC50 12.0 nM
CN1CCC2(CC1)CNC(=O)c1cc(-c3ccnc(-c4cc5ccccc5o4)n3)[nH]c12 CHEMBL1779353 EC50 13.0 nM
CN1CC2(CNC(=O)c3c4c(n(C)c32)-c2cc(-c3ccccc3F)ncc2CC4)C1 CHEMBL1801312 IC50 13.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)cc3Cl)o2)cc1 CHEMBL3314148 IC50 13.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(-c5ccncc5)ccc4c23)C(=O)N1 CHEMBL552339 IC50 14.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(-c5ccccc5F)ccc4c23)C(=O)N1 CHEMBL554286 IC50 14.0 nM
COc1ccc2sc3c(c2c1)NC[C@@H](CO)NC3=O CHEMBL553397 IC50 14.0 nM
NCc1[nH]c2c(ccc3cnc(/C=C/c4ccccc4)cc32)c1C(=O)O CHEMBL1801313 IC50 14.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(NC(=O)c4cccc5ccccc45)n3)cc21 CHEMBL1933165 EC50 14.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3ccccn3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940649 IC50 14.0 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cncc(F)c2)c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL2385540 IC50 14.0 nM
O=C1Nc2ccc(C3CCNCC3)cc2Cc2cc(-c3ccc(Cl)cc3)oc21 CHEMBL2385537 IC50 14.0 nM
Clc1ccc(-c2ccc(-c3nncn3-c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL3314142 IC50 14.3 nM
O=C(NC1CC1)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL226206 IC50 15.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4cccc(C(F)(F)F)c4)n3)cc21 CHEMBL1779356 EC50 15.0 nM
Nc1ccc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)cn1 CHEMBL1779364 EC50 15.0 nM
Nc1ncc(C2CC2)nc1CNC(=S)Nc1ccc2[nH]c(=O)oc2c1 CHEMBL1783712 IC50 15.0 nM
COc1ccc(-c2cc3c(ccc4c5c([nH]c43)CCNC5=O)cn2)cc1F CHEMBL1801386 IC50 15.0 nM
O=C(Nc1nccc(-c2cc3c([nH]2)C2(CCNCC2)CNC3=O)n1)c1ccc(F)cc1 CHEMBL1933167 EC50 15.0 nM
Fc1ccc(-c2cc3c(o2)-c2nncn2-c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL1938688 IC50 15.0 nM
C[C@@H]1CNc2c(sc3ccc4occc4c23)C(=O)N1 CHEMBL557318 IC50 16.0 nM
O=C1NCCc2[nH]c3c(ccc4cnc(-c5cccc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801387 IC50 16.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)cc3F)o2)cc1 CHEMBL3314147 IC50 16.2 nM
O=C(NC1CCCCC1)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL226261 IC50 17.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCCN)cs4)cc3c21 CHEMBL396160 IC50 17.0 nM
O=C1NCC2(CNC2)c2[nH]c3c(c21)CCc1cnc(-c2ccccc2F)cc1-3 CHEMBL1801284 IC50 17.0 nM
Cc1cc(N2CCNCC2)ccc1-n1ccnc1-c1ccc(-c2ccc(C#N)cc2)o1 CHEMBL3314149 IC50 17.4 nM
O=C1NCC2(CCCNC2)c2[nH]c(-c3ccnc(-c4cccnc4)n3)cc21 CHEMBL1779487 EC50 18.0 nM
Clc1ccc(-c2cc3c(o2)-c2nccn2-c2ccc(N4CCNCC4)cc2OC3)cc1 CHEMBL1938691 IC50 18.0 nM
Cc1cnc(-c2ccnc(C(C)(C)C)n2)cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O CHEMBL3962170 IC50 18.0 nM
Cc1nc2ccc(-n3ncc(C(=O)c4cc5ccccc5[nH]4)c3N)cc2[nH]1 CHEMBL3907479 Kd apparent 18.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCCCC5)cs4)cc3n21 CHEMBL270150 IC50 19.0 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 IC50 19.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3cccc(C#N)c3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940646 IC50 19.0 nM
C[C@@H]1CN(Cc2ccc(F)cc2)[C@@H](C)CN1C(=O)c1cc2c(C(=O)C(=O)N(C)C)cn(C)c2cc1Cl CHEMBL514201 Kd apparent 19.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCCCC5)cs4)cc3n21 CHEMBL409727 IC50 20.0 nM
COc1ccccc1-c1ccc2c(ccc3sc4c(c32)NC[C@@H](C)NC4=O)n1 CHEMBL562137 IC50 20.0 nM
Nc1ncc2c(n1)c(-c1cc(-c3cc4ccccc4s3)c3[nH]ncc3c1)cn2CCC(=O)O CHEMBL594090 IC50 20.0 nM
CCCc1cnc(N)c(CNC(=S)Nc2ccc3[nH]c(=O)oc3c2)n1 CHEMBL1783710 IC50 20.0 nM
Cn1c2c(c3c1C1(CNC1)CNC3=O)CCc1cnc(-c3ccccc3F)cc1-2 CHEMBL1801311 IC50 20.0 nM
COc1cncc(-c2ccccc2CN(C(=O)c2ccc(-c3ccc(C#N)cc3)o2)c2ccc(N3CCNCC3)cc2)c1 CHEMBL1940651 IC50 20.0 nM
COc1ccccc1-c1ccccc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL1940656 IC50 20.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccc(O)cc4)c3)cc21 CHEMBL374177 IC50 21.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCCC(N)=O)cs4)cc3c21 CHEMBL246090 IC50 21.0 nM
COCCCOc1ccc(-c2nccc(-c3cc4c([nH]3)C3(CCCNC3)CNC4=O)n2)cn1 CHEMBL1779371 EC50 21.0 nM
Cc1noc(C)c1-c1ccccc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL1940644 IC50 21.0 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cccnc2)c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL2385544 IC50 21.0 nM
COc1cc(-c2ccccc2CN2C(=O)c3oc(-c4ccc(Cl)cc4)cc3Cc3cc(N4CCNCC4)ccc32)ccn1 CHEMBL2385541 IC50 21.0 nM
Cc1cnc(-c2ccnc(C(C)(C)O)n2)cc1-n1c(C)cc(OCc2ncc(F)cc2F)c(Cl)c1=O CHEMBL3704901 IC50 21.0 nM
O=C(O)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL389658 IC50 22.0 nM
O=C1c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc2N1Cc1ccccc1-c1cccnc1 CHEMBL2385543 IC50 22.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)cc3Br)o2)cc1 CHEMBL3314150 IC50 22.3 nM
C[C@@H]1CNc2c(sc3ccc4nc(-c5cncnc5)ccc4c23)C(=O)N1 CHEMBL549585 IC50 23.0 nM
COc1ccc(-c2cc3c(ccc4c5c([nH]c43)CN(C)NC5=O)cn2)cc1 CHEMBL1801316 IC50 23.0 nM
N#Cc1ccc(-c2ccc(-c3nncn3-c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL3314143 IC50 23.3 nM
COc1cncc(-c2nccc(-c3cc4c([nH]3)C3(CCCNC3)CNC4=O)n2)c1 CHEMBL1779370 EC50 24.0 nM
COc1cc(-c2ccccc2CN(C(=O)c2ccc(-c3ccc(C#N)cc3)o2)c2ccc(N3CCNCC3)cc2)ccn1 CHEMBL1940654 IC50 24.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(C4(F)CCNCC4)cc3)o2)cc1 CHEMBL3315291 IC50 24.9 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cccc(O)c4)c3)cc21 CHEMBL388619 IC50 25.0 nM
O=C1NOCc2[nH]c3c(ccc4cnc(/C=C/c5ccccc5)cc43)c21 CHEMBL1801315 IC50 25.0 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 25.12 nM
Clc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL3314140 IC50 25.5 nM
OC1(c2ccc(-n3ccnc3-c3ccc(-c4ccc(Cl)cc4)o3)cc2)CCNCC1 CHEMBL3315290 IC50 25.8 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(C4(O)CCNCC4)cc3)o2)cc1 CHEMBL3315292 IC50 26.0 nM
Clc1ccc(-c2ccc(-c3nccn3-c3ccc(C4CCCNC4)cc3)o2)cc1 CHEMBL3314156 IC50 26.0 nM
O=C1NCC2(CC2)c2[nH]c3c(c21)CCc1cnc(-c2ccc(F)nc2)cc1-3 CHEMBL1801283 IC50 27.0 nM
COc1ccc(-c2cc3c(ccc4c5c([nH]c43)CNC5=O)cn2)cc1 CHEMBL1801377 IC50 27.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3cncnc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940650 IC50 27.0 nM
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cn1 CHEMBL1088752 Kd apparent 27.0 nM
C[C@@H]1CNc2c(sc3ccc4c(c23)CCO4)C(=O)N1 CHEMBL562754 IC50 28.0 nM
O=C1NCC2(CCCNC2)c2[nH]c(-c3ccnc(-c4ccc5c(c4)OCO5)n3)cc21 CHEMBL1779369 EC50 28.0 nM
NCCn1nc(-c2ccnc(-c3cnc4ccccc4c3)c2)cc1C(=O)O CHEMBL1738780 EC50 28.0 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)Nc2ccc(C4CCNCC4)cc2C3)cc1 CHEMBL2385538 IC50 28.0 nM
NCC1CNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n2C1 CHEMBL272309 IC50 29.0 nM
O=C1NCC2(CCNCC2)c2[nH]c(-c3ccnc(-c4ccccc4F)n3)cc21 CHEMBL1779349 EC50 29.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cccc(F)c4)c3)cc21 CHEMBL226472 IC50 30.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cc5ccccc5s4)c3)cc21 CHEMBL226351 IC50 30.0 nM
Cc1ccccc1-c1ccc2c(ccc3sc4c(c32)NC[C@@H](C)NC4=O)n1 CHEMBL562606 IC50 30.0 nM
CC(C)COc1ccc2sc3c(c2c1)NC[C@@H](C)NC3=O CHEMBL563308 IC50 30.0 nM
CCCCc1cnc(N)c(CNC(=S)Nc2ccc3[nH]c(=O)oc3c2)n1 CHEMBL1783711 IC50 30.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccccn4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036456 IC50 30.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccncc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036458 IC50 30.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCCO)cs4)cc3c21 CHEMBL395932 IC50 31.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)cc3C(F)(F)F)o2)cc1 CHEMBL3314151 IC50 31.3 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccc(Cl)cc4)c3)cc21 CHEMBL226470 IC50 32.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(-c5cccc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801380 IC50 32.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCCN(C)C)cs4)cc3c21 CHEMBL245884 IC50 34.0 nM
CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccccc4F)nc3-2)C1 CHEMBL1801303 IC50 34.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCCCN(C)C)cs4)cc3c21 CHEMBL246088 IC50 35.0 nM
NCC1CNC(=O)c2cc3ccc(C(=O)Nc4nccs4)cc3n2C1 CHEMBL429922 IC50 35.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)c(Br)c3)o2)cc1 CHEMBL3314154 IC50 35.7 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 36.25 nM
Clc1ccc(-c2ccc(-c3nccn3-c3ccc(C4CCNCC4)cc3)o2)cc1 CHEMBL3314155 IC50 36.7 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cccc(Cl)c4)c3)cc21 CHEMBL226420 IC50 37.0 nM
Nc1ncc2c(n1)c(-c1cc(-c3cc4ccccc4s3)c3[nH]ncc3c1)cn2CCCO CHEMBL590612 IC50 37.0 nM
O=C1NCCc2[nH]c3c(c21)CCc1cnc(-c2ccccc2F)cc1-3 CHEMBL1801194 IC50 37.0 nM
O=C1c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc2N1Cc1ccccc1-c1ccncc1 CHEMBL2385085 IC50 39.0 nM
COc1ccc2sc3c(c2c1)NC[C@@H](C)NC3=O CHEMBL99780 IC50 40.0 nM
COCCOc1cncc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NCC3)c1 CHEMBL1801195 IC50 40.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccccc4-c4cncnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036606 IC50 40.0 nM
Nc1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL226475 IC50 41.0 nM
COc1cccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)c1 CHEMBL563307 IC50 41.0 nM
NC(=O)CCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL603322 IC50 41.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940516 IC50 41.0 nM
O=C(c1ccc(/C=C/c2cc(-c3cc4c(=O)[nH]cnc4[nH]3)ccn2)cc1)N1CCOCC1 CHEMBL516802 IC50 42.0 nM
COc1ccc(-c2ccccc2CN(C(=O)c2ccc(-c3ccc(C#N)cc3)o2)c2ccc(N3CCNCC3)cc2)cn1 CHEMBL1940653 IC50 43.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)cc3-c3cncnc3)o2)cc1 CHEMBL3314152 IC50 43.5 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NC5CCCCC5)cs4)cc3c21 CHEMBL246300 IC50 44.0 nM
CCCNC(=O)c1csc(NC(=O)c2ccc3[nH]c4c(c3c2)C(C)CNC4=O)n1 CHEMBL246299 IC50 45.0 nM
CC1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C(C)CNC5=O)n2)CC1 CHEMBL437033 IC50 45.0 nM
CCCc1cnc(N)c(CNC(=S)Nc2ccc(NC(=O)OC(C)(C)C)cc2)n1 CHEMBL1783708 IC50 45.0 nM
COc1ccc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NC2(C3)CN(C)C2)cc1 CHEMBL1801295 IC50 45.0 nM
O=C(NCCc1ccccc1)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL226321 IC50 46.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NCC(C)(C)C)cs4)cc3n21 CHEMBL271863 IC50 46.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cccnc4)c3)cc21 CHEMBL225975 IC50 48.0 nM
O=C1NCCc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc21 CHEMBL510545 IC50 49.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccc(F)cc4)c3)cc21 CHEMBL388307 IC50 50.0 nM
O=C1NC2(CC2)Cc2[nH]c3c(c21)CCc1cnc(-c2ccc(F)nc2)cc1-3 CHEMBL1801279 IC50 50.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccccc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036452 IC50 50.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4cccnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036457 IC50 50.0 nM
Fc1ccc(-c2ccc(C3=NOC(c4ccccc4-c4cncnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036610 IC50 50.0 nM
CC(=O)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL226424 IC50 51.0 nM
O=c1[nH]cnc2[nH]c(-c3ccnc(/C=C/c4ccc(CN5CCOCC5)cc4)c3)cc12 CHEMBL461139 IC50 51.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccc5ccccc5c4)c3)cc21 CHEMBL226350 IC50 52.0 nM
O=C(Nc1nccs1)c1ccc2cc3n(c2c1)CC(CO)CNC3=O CHEMBL403193 IC50 52.0 nM
COc1ncc(-c2ccccc2CN(C(=O)c2ccc(-c3ccc(C#N)cc3)o2)c2ccc(N3CCNCC3)cc2)cn1 CHEMBL1940655 IC50 52.0 nM
O=C1c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc2N1Cc1ccccc1Br CHEMBL2385536 IC50 52.0 nM
Cc1nc2ccc(Nc3c(C)c(N[C@H]4CCCNC4)nc4ccnn34)cc2s1 CHEMBL2163608 IC50 54.0 nM
COc1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL226474 IC50 55.0 nM
Clc1ccc(-c2ccc(-c3nccn3-c3ccc([C@H]4CNCCO4)cc3)o2)cc1 CHEMBL3315287 IC50 55.3 nM
CN(Cc1ccccc1)C(=O)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL376384 IC50 56.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccncc4)c3)cc21 CHEMBL225973 IC50 56.0 nM
Nc1ncc2[nH]cc(-c3cc(-c4cc5ccccc5s4)c4[nH]ncc4c3)c2n1 CHEMBL591797 IC50 56.0 nM
CC(=O)c1ccc(-c2ccc(Nc3c(C)c(N[C@H]4CCCNC4)nc4ccnn34)cc2)s1 CHEMBL2163610 IC50 57.0 nM
CCN1CCC2(CC1)CNC(=O)c1cc(-c3ccnc(-c4cc5ccccc5o4)n3)[nH]c12 CHEMBL1779354 EC50 59.0 nM
CNCc1[nH]c2c(ccc3cnc(/C=C/c4ccccc4)cc32)c1C(=O)O CHEMBL1801314 IC50 60.0 nM
Fc1ccc(C2ON=C(c3ccc(-c4ccc(Cl)cc4)o3)N2c2ccc(N3CCNCC3)cc2)nc1 CHEMBL2036459 IC50 60.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccncn4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036460 IC50 60.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](N)CC2)c2nc(-c3ccc(Cl)cc3)cn12 CHEMBL2381601 IC50 60.0 nM
Nc1nn(-c2cccc(-c3ccc4cc[nH]c4c3)c2)cc1-c1ccc2c(c1)CCNC2=O CHEMBL597839 IC50 61.0 nM
N#Cc1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL389657 IC50 62.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 Kd apparent 63.0 nM
O=C1c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc2N1Cc1ccccn1 CHEMBL2385535 IC50 64.0 nM
Clc1ccc(-c2ccc(-c3nccn3-c3ccc(C4C=CCNC4)cc3)o2)cc1 CHEMBL3315286 IC50 65.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4)c3)cc21 CHEMBL388566 IC50 66.0 nM
FC1(c2ccc(-n3ccnc3-c3ccc(-c4ccc(Cl)cc4)o3)cc2)CCNCC1 CHEMBL3315289 IC50 66.5 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1 CHEMBL3991932 Kd apparent 67.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3cccc(-c4ccccc4)c3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940517 IC50 70.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4cncnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036461 IC50 70.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4c[nH]cn4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036601 IC50 70.0 nM
CNC(=O)c1csc(NC(=O)c2ccc3[nH]c4c(c3c2)C(C)CNC4=O)n1 CHEMBL396159 IC50 72.0 nM
COc1ccc(-c2cc3c(ccc4c5c([nH]c43)CCCNC5=O)cn2)cc1 CHEMBL1801091 IC50 72.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(Nc5cccc(F)c5)cc43)c21 CHEMBL1801376 IC50 73.0 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cccc(F)c2)c2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL2385539 IC50 74.0 nM
Clc1ccc(-c2ccc(-c3nccn3-c3ccc([C@@H]4CNCCO4)cc3)o2)cc1 CHEMBL3315288 IC50 74.9 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccsc4)c3)cc21 CHEMBL388391 IC50 76.0 nM
Cc1c(N[C@H]2CCCNC2)nc2ccnn2c1Nc1ccc2c(cnn2C)c1 CHEMBL2163611 IC50 76.0 nM
Cc1cccc(CN(C(=O)c2ccc(-c3ccc(C#N)cc3)o2)c2ccc(N3CCNCC3)cc2)n1 CHEMBL1940513 IC50 79.0 nM
CN1C(=O)c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc21 CHEMBL2385531 IC50 79.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 79.43 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 79.43 nM
COc1ccc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NCC3)cc1 CHEMBL1801275 IC50 80.0 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(-c5cncc(OCCN6CCOCC6)c5)cc43)c21 CHEMBL1801089 IC50 80.0 nM
CN(C)CCOc1ccc(/C=C/c2cc(-c3cc4c(=O)[nH]cnc4[nH]3)ccn2)cc1 CHEMBL461140 IC50 82.0 nM
Nc1nn(-c2cccc(-c3ccc4nc[nH]c4c3)c2)cc1-c1ccc2c(c1)CCNC2=O CHEMBL597640 IC50 82.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cncnc4)c3)cc21 CHEMBL390601 IC50 83.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(N)=O)cs4)cc3c21 CHEMBL397332 IC50 83.0 nM
CC(C)(C)NC(=O)Nc1ccc(NC(=S)NCc2nc(C3CC3)cnc2N)cc1 CHEMBL1783713 IC50 83.0 nM
COc1ccc(-n2cc(-c3ccc4c(c3)C(=O)NCC4)c(N)n2)cc1 CHEMBL610780 IC50 84.0 nM
N#Cc1ccc(-c2ccc(-c3nccn3-c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL3314141 IC50 84.7 nM
O=C1NCc2[nH]c3c(ccc4cnc(-c5ccccc5F)cc43)c21 CHEMBL1801378 IC50 85.0 nM
O=C(c1ccc(-c2ccc(Cl)cc2)o1)N(Cc1ccncc1)c1ccc(N2CCNCC2)cc1 CHEMBL2017619 IC50 90.0 nM
O=C1NC[C@]2(CCCNC2)c2[nH]c(-c3ccnc(-c4ccc5c(c4)OCO5)n3)cc21 CHEMBL1779373 EC50 91.0 nM
Clc1ccc(-c2ccc(-c3nc4ccccc4n3-c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL3314146 IC50 95.4 nM
CN1CCN(c2ccc(Nc3ccnc4ccc(-c5ccc(Cl)cc5)cc34)cc2)CC1 CHEMBL1208951 Ki 96.0 nM
COCCOc1cncc(-c2cc3c(ccc4c5c([nH]c43)CCCNC5=O)cn2)c1 CHEMBL1801090 IC50 96.0 nM
O=C1Nc2ccc(N3CCNCC3)cc2Cc2cc(-c3ccc(Cl)cc3)oc21 CHEMBL1938682 IC50 96.0 nM
O=C1NC2(CC2)Cc2[nH]c3c(c21)CCc1cnc(-c2ccc(OCCN4CCOCC4)cc2)cc1-3 CHEMBL1801280 IC50 100.0 nM
O=C1NCC2(CC2)c2[nH]c3c(c21)CCc1cnc(-c2cccc(F)c2)cc1-3 CHEMBL1801281 IC50 100.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3cccnc3-c3cncnc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940659 IC50 100.0 nM
Cn1ccnc1CN(C(=O)c1ccc(-c2ccc(Cl)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL2017463 IC50 100.0 nM
Fc1ccc(C2ON=C(c3ccc(-c4ccc(Cl)cc4)o3)N2c2ccc(N3CCNCC3)cc2)c(F)c1 CHEMBL2036599 IC50 100.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccc(-c5cncnc5)cc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036604 IC50 100.0 nM
CC(C)(C)OC(=O)Nc1ccc(NC(=S)NCc2nc(C3CC3)cnc2N)cc1 CHEMBL1783709 IC50 103.0 nM
O=C1c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc2N1CC(F)F CHEMBL2385534 IC50 107.0 nM
COc1cccc(COc2ccc3sc4c(c3c2)NC[C@@H](C)NC4=O)c1 CHEMBL541448 IC50 110.0 nM
O=C(c1ccc(-c2ccc(Cl)cc2)o1)N(Cc1ccccn1)c1ccc(N2CCNCC2)cc1 CHEMBL1938681 IC50 110.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3cccc(-c4ccncc4)c3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940523 IC50 110.0 nM
N#Cc1ccc(-c2cc3c(o2)C(=O)Nc2ccc(N4CCNCC4)cc2C3)cc1 CHEMBL1938683 IC50 110.0 nM
O=C1Nc2ccc(N3CCNCC3)cc2OCc2cc(-c3ccc(Cl)cc3)oc21 CHEMBL1938692 IC50 110.0 nM
N#Cc1ccc(-c2ccc(C3=NOCCN3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036454 IC50 110.0 nM
O=C1c2oc(-c3ccc(Cl)cc3)cc2Cc2cc(N3CCNCC3)ccc2N1CC1CC1 CHEMBL2385533 IC50 110.0 nM
CC(C)c1cccc(-c2nccc(-c3cc4c([nH]3)C3(CCNCC3)CNC4=O)n2)c1 CHEMBL1779348 EC50 112.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccn3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940509 IC50 115.0 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(/C=C/c5ccccc5)cc43)c21 CHEMBL1801390 IC50 116.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4ncc(C(N)=O)s4)cc3c21 CHEMBL245682 IC50 120.0 nM
CC(=O)N1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccccc4F)cc3-2)C1 CHEMBL1801293 IC50 120.0 nM
O=C1NC2(CC2)Cc2[nH]c3c(c21)CCc1cnc(-c2ccc(F)nc2)nc1-3 CHEMBL1801300 IC50 120.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)NCC(N)=O)cs4)cc3c21 CHEMBL246089 IC50 124.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 IC50 126.0 nM
COc1cncc(-c2nccc(-c3cc4c([nH]3)[C@@]3(CCCNC3)CNC4=O)n2)c1 CHEMBL1779375 EC50 126.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccc(-c4ccncc4)cc3)c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL1940522 IC50 128.0 nM
COCCCOc1ccc(-c2nccc(-c3cc4c([nH]3)[C@@]3(CCCNC3)CNC4=O)n2)cn1 CHEMBL1779486 EC50 129.0 nM
N#Cc1c(N)cc2c(c1N)Cc1cc(O)c(O)cc1O2 CHEMBL3706781 IC50 130.0 nM
COc1ccc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NCC32CC2)cc1 CHEMBL1801282 IC50 130.0 nM
CCN(C(=O)c1ccc(-c2ccc(Cl)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL2017459 IC50 130.0 nM
N#Cc1c(N)nc2c(c1N)Cc1cc(O)c(O)cc1O2 CHEMBL1185204 IC50 130.0 nM
COCCOc1ccc(Nc2c(C)c(N[C@H]3CCCNC3)nc3ccnn23)cc1 CHEMBL2163616 IC50 130.0 nM
CCOc1ccc(Nc2c(C)c(N[C@H]3CCCNC3)nc3ccnn23)cc1 CHEMBL1235213 IC50 130.0 nM
NCC1Cc2c([nH]c3ccc(C(=O)Nc4nccs4)cc23)C(=O)N1 CHEMBL270203 IC50 140.0 nM
CCc1cnc(N)c(CNC(=S)Nc2ccc(NC(=O)OC(C)(C)C)cc2)n1 CHEMBL1783707 IC50 140.0 nM
O=C1NC2(CC2)Cc2[nH]c3c(c21)CCc1cnc(-c2ccccc2F)cc1-3 CHEMBL1801276 IC50 140.0 nM
Cc1c(N[C@H]2CCCNC2)nc2ccnn2c1Nc1ccc(C(=O)NC2CCCC2)cc1 CHEMBL2163609 IC50 140.0 nM
CCN(CC)Cc1ccc(/C=C/c2cc(-c3cc4c(=O)[nH]cnc4[nH]3)ccn2)cc1 CHEMBL461316 IC50 150.0 nM
C[C@@H]1CNc2c(sc3ccc4oc(-c5ccccc5)cc4c23)C(=O)N1 CHEMBL562194 IC50 150.0 nM
CC(C)COC(=O)Nc1ccc(NC(=S)NCc2nc(Cl)cnc2N)cc1 CHEMBL1783688 IC50 150.0 nM
COc1ccc(-c2ncc3c(n2)-c2[nH]c4c(c2CC3)C(=O)NCC42CC2)cc1 CHEMBL1801302 IC50 150.0 nM
NCC1CNC(=O)c2cc(-c3ccnc(-c4cnc5ccccc5c4)c3)nn21 CHEMBL1779517 EC50 151.0 nM
Clc1ccc(-c2ccc(-c3ncnn3-c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL3314144 IC50 157.0 nM
NC[C@@H]1Cn2c(cc3ccc(C(=O)Nc4nccs4)cc32)C(=O)N1 CHEMBL404224 IC50 160.0 nM
Nc1nccc(Nc2ccc3[nH]nc(-c4cc5ccccc5s4)c3c2)n1 CHEMBL600081 IC50 160.0 nM
Nc1nccc(Nc2ccc3[nH]nc(-c4ccc[nH]4)c3c2)n1 CHEMBL592288 IC50 160.0 nM
COc1ccc(-c2cc3c(ccc4c5c([nH]c43)CCC5=O)cn2)cc1F CHEMBL1801389 IC50 160.0 nM
Fc1ccc(C2ON=C(c3ccc(-c4ccc(Cl)cc4)o3)N2c2ccc(N3CCNCC3)cc2)cc1 CHEMBL2036598 IC50 160.0 nM
Cc1c(N[C@H]2CCCNC2)nc2ccnn2c1Nc1ccc(OCCN2CCOCC2)cc1 CHEMBL2163612 IC50 160.0 nM
Clc1ccc(-c2ccc(-c3nccn3-c3ccc(C4CCCCN4)cc3)o2)cc1 CHEMBL3314157 IC50 160.0 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(-c5ccccc5OCCN5CCOCC5)cc43)c21 CHEMBL1801088 IC50 167.0 nM
O=c1[nH]cnc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc12 CHEMBL507348 IC50 170.0 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 IC50 171.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccc(C(F)(F)F)cc4)c3)cc21 CHEMBL226369 IC50 171.0 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(/C=C/c5cccc(CCN6CCOCC6)c5)cc43)c21 CHEMBL1801392 IC50 172.0 nM
COc1ccc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NC2(CC2)C3)cc1 CHEMBL1801278 IC50 175.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3cccnc3)c3ccc(N4CCNCC4)cc3)o2)cn1 CHEMBL1940661 IC50 177.0 nM
N#Cc1c(N)cc2c(c1N)Cc1ccc(O)cc1O2 CHEMBL3706766 IC50 180.0 nM
COc1ccc2sc3c(c2c1)NCCNC3=O CHEMBL319171 IC50 180.0 nM
Nc1nn(-c2cccc(-c3cccc(O)c3)c2)cc1-c1ccc2c(c1)CCNC2=O CHEMBL603694 IC50 180.0 nM
COc1cccc(-c2cccc(-n3cc(-c4ccc5c(c4)CCNC5=O)c(N)n3)c2)c1 CHEMBL599682 IC50 180.0 nM
CS(=O)(=O)Nc1cccc(-c2cccc(-n3cc(-c4ccc5c(c4)CCNC5=O)c(N)n3)c2)c1 CHEMBL605125 IC50 180.0 nM
COCCOc1cncc(-c2cc3c(cn2)CCCc2c-3[nH]c3c2C(=O)NCC3)c1 CHEMBL1801196 IC50 180.0 nM
O=C1NC2(CC2)Cc2[nH]c3c(c21)CCc1cnc(-c2ccc(OCCN4CCOCC4)cc2)nc1-3 CHEMBL1801301 IC50 180.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccccc4-c4cccnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036607 IC50 180.0 nM
O=C(Nc1nccs1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL403436 IC50 190.0 nM
O=C(Nc1cc(-c2cc3c(=O)[nH]cnc3[nH]2)ccn1)c1ccc(C2CCCC2)cc1 CHEMBL455156 IC50 190.0 nM
C[C@@H]1CNc2c(sc3ccc(O)cc23)C(=O)N1 CHEMBL559487 IC50 190.0 nM
CC(C)(C)OC(=O)Nc1ccc(NC(=S)NCc2nc(Cl)cnc2N)cc1 CHEMBL1783689 IC50 190.0 nM
Fc1cc(F)cc(C2ON=C(c3ccc(-c4ccc(Cl)cc4)o3)N2c2ccc(N3CCNCC3)cc2)c1 CHEMBL2036600 IC50 190.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccncc4)N3c3ccc(C4CCNCC4)cc3)o2)cc1 CHEMBL2036618 IC50 190.0 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 199.53 nM
O=c1[nH]cnc2[nH]c(-c3ccnc(/C=C/c4ccc(F)cc4)c3)cc12 CHEMBL516504 IC50 200.0 nM
O=C1NCC2(CNC2)c2[nH]c3c(c21)CCc1cnc(-c2cccc(F)c2)cc1-3 CHEMBL1801285 IC50 200.0 nM
CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4cccc(F)c4)cc3-2)C1 CHEMBL1801287 IC50 200.0 nM
O=C1NCC2(CNC2)c2oc3c(c21)CCc1cnc(-c2cccc(F)c2)cc1-3 CHEMBL1801309 IC50 200.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccccc3Cl)n3nccc3n2)CC1 CHEMBL2163607 IC50 200.0 nM
CNCC1Cc2c([nH]c3ccc(C(=O)Nc4nccs4)cc23)C(=O)N1 CHEMBL269988 IC50 210.0 nM
Cc1cnc(N)c(CNC(=S)Nc2ccc(NC(=O)OC(C)(C)C)cc2)n1 CHEMBL1783692 IC50 210.0 nM
Cc1cnc(N)c(CNC(=S)Nc2ccc3[nH]c(=O)oc3c2)n1 CHEMBL1783701 IC50 210.0 nM
Nc1nn(-c2cccc(-c3ccc4c(c3)NC(=O)C4)c2)cc1-c1ccc2c(c1)CCNC2=O CHEMBL598324 IC50 220.0 nM
Fc1cc(-c2ccc(C3=NOC(c4ccccc4-c4cncnc4)N3c3ccc(N4CCNCC4)cc3)o2)ccc1Cl CHEMBL2036612 IC50 220.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 230.0 nM
CCCCOC(=O)Nc1ccc(NC(=S)NCc2nc(Cl)cnc2N)cc1 CHEMBL1783687 IC50 230.0 nM
CN1CC2(CNC(=O)c3c2[nH]c2c3Cc3cnc(-c4ccccc4F)cc3-2)C1 CHEMBL1801273 IC50 230.0 nM
O=C1NC2(CC2)Cc2[nH]c3c(c21)CCc1cnc(-c2cccc(F)c2)cc1-3 CHEMBL1801277 IC50 230.0 nM
O=C1NCC2(CN(CCF)C2)c2[nH]c3c(c21)CCc1cnc(-c2ccccc2F)cc1-3 CHEMBL1801292 IC50 230.0 nM
O=C1NCC2(CCCC2)c2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)n3)cc21 CHEMBL1779516 EC50 234.0 nM
N#Cc1c(N)cc2c(c1NCCO)Cc1cc(O)c(O)cc1O2 CHEMBL3706783 IC50 237.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)N5CCC(N(C)C)CC5)cs4)cc3c21 CHEMBL397642 IC50 250.0 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 251.19 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 251.19 nM
O=C1NCCCc2[nH]c3c(ccc4cnc(/C=C/c5ccc(CN6CCOCC6)cc5)cc43)c21 CHEMBL1801391 IC50 253.0 nM
Cc1cccc(C)c1-c1ccccc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL1938419 IC50 258.0 nM
N#Cc1ccc(-c2ccc(C(=O)N(Cc3ccccc3-c3ccccc3)c3ccc(N4CCNCC4)cc3)o2)cn1 CHEMBL1940660 IC50 258.0 nM
NCC1Cc2c([nH]c3ccc(C(=O)Nc4cccnc4)cc23)C(=O)N1 CHEMBL255605 IC50 260.0 nM
NCCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL591329 IC50 260.0 nM
O=C(Nc1cccnc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL255210 IC50 270.0 nM
COCCOc1ccc2sc3c(c2c1)NC[C@@H](C)NC3=O CHEMBL559411 IC50 270.0 nM
COc1ccc(-c2ncc3c(n2)-c2[nH]c4c(c2CC3)C(=O)NCC4)cc1 CHEMBL1801297 IC50 270.0 nM
Cc1ccccc1-c1ccccc1CN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL1940643 IC50 285.0 nM
O=C1NC[C@]2(CCCNC2)c2[nH]c(-c3ccnc(-c4cccnc4)n3)cc21 CHEMBL1779489 EC50 288.0 nM
COc1ccc2[nH]c3c(c2c1)C1CCN(C1)C3C(=O)O CHEMBL392876 IC50 290.0 nM
Nc1nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc2c(=O)[nH]1 CHEMBL518824 IC50 290.0 nM
Cn1ccc2ccc(-c3cccc(-n4cc(-c5ccc6c(c5)CCNC6=O)c(N)n4)c3)cc21 CHEMBL604510 IC50 290.0 nM
COc1ccc2sc3c(c2c1)NC[C@H](C)NC3=O CHEMBL100818 IC50 300.0 nM
CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccccc4F)cc3-2)C1 CHEMBL1233942 IC50 300.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CC[C@H](N(C)C)C3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cncnc2)n1 CHEMBL206834 Kd apparent 304.0 nM
CN(C)CC1CNC(=O)c2cc3ccc(C(=O)Nc4nccs4)cc3n2C1 CHEMBL271713 IC50 310.0 nM
Nc1nccc(Nc2ccc3[nH]nc(-c4ccc5ccccc5c4)c3c2)n1 CHEMBL590834 IC50 310.0 nM
CCOC(=O)Nc1ccc(NC(=S)NCc2nc(Cl)cnc2N)cc1 CHEMBL1783686 IC50 310.0 nM
COc1ccc(-c2ccc(C3=NOC(c4ccccc4-c4cncnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036614 IC50 310.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 316.23 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n2C1 CHEMBL272096 IC50 320.0 nM
NC[C@@H]1Cn2c(cc3ccc(C(=O)Nc4cccnc4)cc32)C(=O)N1 CHEMBL402957 IC50 320.0 nM
COc1cc2c(cc1OC)Oc1cc(N)c(C#N)c(N)c1C2 CHEMBL3706770 IC50 330.0 nM
O=C(CCCc1ccc(-c2ccccc2F)cc1)Nc1ccc(O)cc1 CHEMBL235658 Ki app 330.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccc(-c5ncccn5)cc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036603 IC50 330.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nc(C(=O)N(C)C)cs4)cc3c21 CHEMBL245883 IC50 333.0 nM
O=c1[nH]c(Cc2ccccc2)nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc12 CHEMBL460091 IC50 340.0 nM
Cc1nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc2c(=O)[nH]1 CHEMBL504267 IC50 350.0 nM
COc1ccc(-n2cc(-c3ccc4c(c3)C(=O)NCCO4)c(N)n2)cc1 CHEMBL599479 IC50 350.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1 CHEMBL3545328 Kd apparent 354.0 nM
CCOc1ccc(Nc2c(C)c(N[C@H]3CC[C@H](N)CC3)nc3ccnn23)cc1 CHEMBL2163981 IC50 360.0 nM
COc1ccc(-c2ncc3c(c2F)-c2[nH]c4c(c2CC3)C(=O)NCC42CN(C)C2)cc1F CHEMBL4282514 IC50 370.0 nM
CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4cccc(F)c4)c(F)c3-2)C1 CHEMBL4277929 IC50 370.0 nM
CC(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1 CHEMBL467532 IC50 380.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4cccc(-c5cncnc5)c4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036605 IC50 380.0 nM
NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1 CHEMBL511410 IC50 390.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 390.0 nM
CN1CCN(c2ccc(Nc3ccnc4ccc(-c5ccc(Br)cc5)cc34)cc2)CC1 CHEMBL1208950 IC50 400.0 nM
CCOc1ccc(Nc2c(C)c(NC3CCCNC3)nc3ccnn23)cc1 CHEMBL2163628 IC50 400.0 nM
Fc1ccc(Nc2cc(NC3CCCNC3)nc3ccnn23)cc1Cl CHEMBL2163984 IC50 400.0 nM
CCc1c(N[C@H]2CC[C@H](N)CC2)nc2ccnn2c1Nc1ccc(F)c(Cl)c1 CHEMBL2163993 IC50 400.0 nM
Cc1c(N[C@H]2CC[C@H](N)CC2)nc2ccnn2c1Nc1ccc(F)c(Cl)c1 CHEMBL2163994 IC50 400.0 nM
CN[C@H]1CC[C@H](Nc2ncc(C(N)=O)n3cc(-c4ccc(Cl)cc4)nc23)CC1 CHEMBL2381600 IC50 400.0 nM
CCCNc1c(C#N)c(N)cc2c1Cc1cc(O)c(O)cc1O2 CHEMBL3706768 IC50 403.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4O)c3)cc21 CHEMBL226405 IC50 410.0 nM
CCNc1c(C#N)c(N)cc2c1Cc1cc(O)c(O)cc1O2 CHEMBL3706769 IC50 419.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4cnccn4)cc3c21 CHEMBL392596 IC50 440.0 nM
CCCCN(C(=O)c1ccc(-c2ccc(Cl)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL2017462 IC50 440.0 nM
CCCNC[C@@H]1CNc2c(sc3ccc(OC)cc23)C(=O)N1 CHEMBL560737 IC50 450.0 nM
N#Cc1ccc(-c2ccc(-c3nnnn3-c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL3314145 IC50 450.1 nM
N#Cc1c(N)cc2c(c1N)Cc1cccc(O)c1O2 CHEMBL3706771 IC50 460.0 nM
Nc1ncc(Cl)nc1CNC(=S)Nc1ccc(NC(=O)OCc2ccccc2)cc1 CHEMBL1783670 IC50 460.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 Kd apparent 468.0 nM
N#Cc1c(N)cc2c(c1N)Cc1cc(O)ccc1O2 CHEMBL3706767 IC50 470.0 nM
Nc1ncc(C2CC2)nc1CNC(=S)Nc1ccccc1 CHEMBL1783563 IC50 470.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4ncc(C(=O)NCCCN(C)C)s4)cc3c21 CHEMBL246508 IC50 480.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccccc4-c4ccccc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1 CHEMBL2036608 IC50 480.0 nM
COc1ccc(-c2ncc3c(c2F)-c2[nH]c4c(c2CC3)C(=O)NCC42CN(C)C2)cn1 CHEMBL4293121 IC50 480.0 nM
N#Cc1c(N)cc2c(c1N)Cc1cc3c(cc1O2)OCCO3 CHEMBL3706773 IC50 490.0 nM
CC(C)n1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL595933 IC50 490.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd apparent 490.0 nM
COc1ccc2sc3c(c2c1)CCCNC3=O CHEMBL571897 IC50 500.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCO)c(Cl)cc1NC(=O)N2 CHEMBL413779 pKi 501.19 nM
Nc1nccc(-c2cc3c([nH]2)[C@@H](CCF)CNC3=O)n1 CHEMBL524266 IC50 510.0 nM
Cc1c(NC2CCCNC2)nc2ccnn2c1Nc1ccc(F)c(Cl)c1 CHEMBL2163624 IC50 510.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4cccnc4)cc3c21 CHEMBL437943 IC50 520.0 nM
N#Cc1c(N)cc2c(c1N)Cc1cc(N)ccc1O2 CHEMBL3706774 IC50 530.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nccs4)cc3n2C1 CHEMBL410902 IC50 530.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd apparent 538.0 nM
CC(=O)/C1=C/Cn2c3ccccc3c3c4c(c5c6ccccc6n(c5c32)C1)C(=O)NC4=O CHEMBL557101 IC50 540.0 nM
COc1ccc(-c2cc(-c3cc4c(=O)[nH]cnc4[nH]3)ccn2)cc1 CHEMBL455396 IC50 540.0 nM
O=C(Nc1nccs1)c1ccc2cc3n(c2c1)CC(CO)NC3=O CHEMBL272572 IC50 550.0 nM
N#Cc1c(N)cc2c(c1N)Cc1ccccc1O2 CHEMBL3706775 IC50 560.0 nM
CCNCC1CNC(=O)c2cc3ccc(C(=O)Nc4nccs4)cc3n2C1 CHEMBL271714 IC50 560.0 nM
CCNC[C@@H]1CNc2c(sc3ccc(OC)cc23)C(=O)N1 CHEMBL550060 IC50 570.0 nM
COc1ccc2sc3c(c2c1)NC[C@@H](CNCc1ccccc1)NC3=O CHEMBL551534 IC50 570.0 nM
CCOc1ccc(Nc2c(C)c(O[C@H]3CC[C@H](N)CC3)nc3ccnn23)cc1 CHEMBL2163625 IC50 570.0 nM
CNCC1Cn2c(cc3ccc(C(=O)Nc4nccs4)cc32)C(=O)N1 CHEMBL258107 IC50 580.0 nM
Cc1cnc(N)c(CNC(=S)Nc2ccc(NC(=O)c3ccccc3)cc2)n1 CHEMBL1783700 IC50 580.0 nM
CN(C(=O)c1ccc(-c2ccc(Cl)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL2017458 IC50 600.0 nM
CCCc1c(N[C@H]2CC[C@H](N)CC2)nc2ccnn2c1Nc1ccc(F)c(Cl)c1 CHEMBL2163992 IC50 600.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4Cl)c3)cc21 CHEMBL426001 IC50 606.0 nM
O=C1NCCc2[nH]c(-c3ccnc(Cl)c3)cc21 CHEMBL226232 IC50 608.0 nM
N#Cc1c(N)cc2c(c1N)Cc1cc(O)c(C3COCCO3)cc1O2 CHEMBL3706776 IC50 620.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4ccc(C(N)=O)nc4)cc3c21 CHEMBL247333 IC50 620.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4ccc(C(N)=O)cc4)cc3c21 CHEMBL442419 IC50 620.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 630.96 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1991728 pKi 630.96 nM
CCCN(C(=O)c1ccc(-c2ccc(Cl)cc2)o1)c1ccc(N2CCNCC2)cc1 CHEMBL2017460 IC50 650.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2nc(-c3ccc(Cl)cc3)cn12 CHEMBL2381596 IC50 650.0 nM
C[C@@H](Nc1c(Nc2ccnc(Nc3ccncn3)c2)c(=O)c1=O)c1ccccc1 CHEMBL469124 IC50 670.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 Kd apparent 682.0 nM
N#Cc1c(N)cc2c(c1N)Cc1c(O)cc(O)cc1O2 CHEMBL3706777 IC50 690.0 nM
CNCC1CNC(=O)c2cc3ccc(C(=O)Nc4nccs4)cc3n2C1 CHEMBL409876 IC50 690.0 nM
CN1CCN(c2ccc(Nc3ccnc4ccc(-c5ccc(F)cc5)cc34)cc2)CC1 CHEMBL1209008 IC50 700.0 nM
CSc1ccc(-c2ccc3nccc(Nc4ccc(N5CCN(C)CC5)cc4)c3c2)cc1 CHEMBL1209120 IC50 700.0 nM
CC(C)(C)NC(=O)Nc1ccc(NC(=S)NCc2nc(Cl)cnc2N)cc1 CHEMBL1783691 IC50 700.0 nM
COc1ccc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NCC32CN(C)C2)cc1 CHEMBL1801288 IC50 700.0 nM
Cc1c(N[C@H]2CC[C@H](N)CC2)nc2ccnn2c1Nc1ccc(OCc2ccccc2)cc1 CHEMBL2163617 IC50 700.0 nM
CCOC(=O)c1ccc(Nc2c(C)c(N[C@H]3CC[C@H](N)CC3)nc3ccnn23)cc1 CHEMBL2163618 IC50 700.0 nM
CCc1c(NC2CCCNC2)nc2ccnn2c1Nc1ccc(F)c(Cl)c1 CHEMBL2163623 IC50 700.0 nM
Nc1nccc(Nc2cc(-c3ccc4ccccc4c3)c3[nH]ncc3c2)n1 CHEMBL589650 IC50 720.0 nM
O=C1NCC2(CCOCC2)c2[nH]c(-c3ccnc(-c4ccc5c(c4)OCO5)n3)cc21 CHEMBL1779351 EC50 724.0 nM
Cc1cnc(N)c(CNC(=S)Nc2ccc(NC(=O)Oc3ccccc3)cc2)n1 CHEMBL1783693 IC50 730.0 nM
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)C(C)C CHEMBL3808687 IC50 740.0 nM
COC(=O)c1csc(NC(=O)c2ccc3[nH]c4c(c3c2)C(C)CNC4=O)n1 CHEMBL245485 IC50 750.0 nM
CCCc1cnc(N)c(CNC(=O)Nc2ccc3[nH]c(=O)oc3c2)n1 CHEMBL3629325 IC50 750.0 nM
COC(=O)c1ccc(NC(=O)c2ccc3[nH]c4c(c3c2)C(C)CNC4=O)cn1 CHEMBL394926 IC50 760.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4ccncc4)cc3c21 CHEMBL247509 IC50 760.0 nM
CCOc1cc2c(cc1O)Cc1c(cc(N)c(C#N)c1N)O2 CHEMBL3706778 IC50 770.0 nM
COC(=O)c1cnc(NC(=O)c2ccc3[nH]c4c(c3c2)C(C)CNC4=O)s1 CHEMBL245680 IC50 770.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4cccc(C#N)c4)cc3c21 CHEMBL246910 IC50 770.0 nM
c1ccc(C2ON=C(c3ccc(-c4ccncc4)o3)N2c2ccc(N3CCNCC3)cc2)c(-c2cncnc2)c1 CHEMBL2036613 IC50 790.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 794.33 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(Cl)c(Cl)ccc12 CHEMBL2006010 pKi 794.33 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 794.33 nM
N#CC1=C(N)n2c(sc(=Cc3ccco3)c2=O)=C(C(N)=O)C1c1ccco1 CHEMBL1989805 pKi 794.33 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCCO)c(Cl)cc1NC(=O)N2 CHEMBL373598 pKi 794.33 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 794.33 nM
Cc1ccc(-c2ccc3nccc(Nc4ccc(N5CCN(C)CC5)cc4)c3c2)cc1 CHEMBL1209121 IC50 800.0 nM
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 CHEMBL1173655 Kd apparent 817.0 nM
CC1CNC(=O)c2[nH]c3ccc(C(=O)Nc4nccs4)cc3c21 CHEMBL247510 IC50 820.0 nM
COCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL591783 IC50 820.0 nM
NC(=O)c1cnc(N[C@H]2CC[C@H](N)CC2)c2nc(-c3ccc(Cl)c(Cl)c3)cn12 CHEMBL2381603 IC50 820.0 nM
NC(=O)c1ncc(N[C@H]2CCCNC2)c2nc(-c3ccc(Cl)cc3)cn12 CHEMBL2381611 IC50 840.0 nM
N#Cc1c(N)cc2c(c1N)Cc1ccc(O)c(O)c1O2 CHEMBL3706779 IC50 850.0 nM
O=C1NC2(CC2)Cc2[nH]c3c(c21)CCc1cnc(-c2ccccc2F)nc1-3 CHEMBL1801298 IC50 860.0 nM
Cc1nnc2n1-c1ccc(N3CCNCC3)cc1Cc1cc(-c3ccc(Cl)cc3)oc1-2 CHEMBL1938690 IC50 880.0 nM
COc1ccc(-c2ncc3c(n2)-c2[nH]c4c(c2CC3)C(=O)NC2(CC2)C4)cc1 CHEMBL1801299 IC50 900.0 nM
O=C1NCc2[nH]c3c(ccc4cnc(-c5ccccc5C(F)(F)F)cc43)c21 CHEMBL1801379 IC50 900.0 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1csc(-c2ccc(Cl)cc2)n1 CHEMBL2017455 EC50 900.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2nc(-c3ccc(F)cc3)cn12 CHEMBL2381605 IC50 910.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2nc(-c3ccc4ccccc4c3)cn12 CHEMBL2381604 IC50 910.0 nM
COC(=O)c1ccc(NC(=O)c2ccc3[nH]c4c(c3c2)C(C)CNC4=O)cc1 CHEMBL246082 IC50 930.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950289 Kd apparent 934.0 nM
COC(=O)Nc1ccc(NC(=S)NCc2nc(Cl)cnc2N)cc1 CHEMBL1783685 IC50 940.0 nM
Nc1ncc2c(n1)c(-c1cc(-c3cc4ccccc4s3)c3[nH]ncc3c1)cn2CCC1CCNCC1 CHEMBL592031 IC50 960.0 nM
Clc1ccc(-c2ccc(C3=NOC(c4ccccc4-c4cncnc4)N3c3ccc(N4CCNCC4)cc3)o2)cc1Cl CHEMBL2036611 IC50 970.0 nM