CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.297 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 0.3981 nM
N[C@@H]1CCCC(F)(F)C1NC(=O)c1cc(-c2cnc3cc(-c4ccc(F)cc4)cnn23)cs1 CHEMBL3648448 IC50 0.5 nM
Cc1cc(O)nc2[nH]nc(-c3cccc(-c4ccc(C#N)cc4)c3)c12 CHEMBL2000724 pKi 1.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@H]5N)c4)cnn3c2)cn1 CHEMBL4532781 IC50 1.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 1.0 nM
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 CHEMBL3884319 IC50 1.2 nM
Cc1sc(C(=O)N[C@@H]2CCCC[C@@H]2N)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 CHEMBL4550486 IC50 1.3 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4528550 IC50 2.0 nM
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cccnc12 CHEMBL4552799 IC50 2.4 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@H]5N)c4)cnn3c2)cn1 CHEMBL4562217 IC50 3.0 nM
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3cccc(CN4CCCC4)c3)ncc21 CHEMBL5305160 IC50 3.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 3.981 nM
COCCOc1ccc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cc1 CHEMBL4593028 IC50 5.0 nM
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 CHEMBL4552628 IC50 5.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 6.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 6.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 6.31 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 7.943 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5O)c4)cnn3c2)cn1 CHEMBL4579339 IC50 9.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NC(CO)C5CC5)c4)cnn3c2)cn1 CHEMBL4571737 IC50 9.0 nM
C[C@@H](c1cccc(O)c1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 CHEMBL3884318 IC50 10.0 nM
CC1(C)C(=O)N([C@H]2CCc3c(N)cccc32)c2nc(Nc3ccccc3)ncc21 CHEMBL3883979 IC50 10.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@H]5O)c4)cnn3c2)cn1 CHEMBL4543195 IC50 10.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCCC(N)C(F)(F)F)c4)cnn3c2)cn1 CHEMBL4569165 IC50 10.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)C4CCCCC4)CC3)c2n1 CHEMBL4875028 Kd 11.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 12.0 nM
O=C(NCCCNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C1CC1)C1CCC1 CHEMBL2207198 IC50 12.0 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 12.59 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 13.0 nM
Cn1cnc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)c1 CHEMBL4547786 IC50 13.0 nM
CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccc(N4CCNCC4)c3)ncc21 CHEMBL3884535 IC50 14.0 nM
N[C@H]1CCCC(F)(F)C1NC(=O)c1cc(-c2cnc3cccnn23)cs1 CHEMBL3648449 IC50 15.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc5c(c4)OCC5)cnc23)cs1 CHEMBL4557345 IC50 15.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCCC(N)C(F)F)c4)cnn3c2)cn1 CHEMBL4578265 IC50 15.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 15.85 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 16.0 nM
CC1(C)C(=O)N([C@H]2CCc3c(NS(C)(=O)=O)cccc32)c2nc(Nc3ccccc3)ncc21 CHEMBL3884344 IC50 19.0 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 19.95 nM
Cn1cc(Nc2ncc(C3CC3)c(NCCCNC(=O)C3CCC3)n2)cn1 CHEMBL2207208 IC50 20.0 nM
Cc1sc(C(=O)NC2[C@H](N)CCCC2(F)F)cc1-c1cnc2cccnn12 CHEMBL3648447 IC50 20.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 21.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCCC(N)CF)c4)cnn3c2)cn1 CHEMBL4589674 IC50 22.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@H]5O)c4)cnn3c2)cn1 CHEMBL4544609 IC50 24.0 nM
CC1(C)C(=O)N([C@H]2CCc3ccccc32)c2nc(Nc3cccnc3)ncc21 CHEMBL3883433 IC50 27.0 nM
C[C@@]1(N2CCC(c3cc4cc(NC(=O)C5CC56CC6)ncc4cc3Cl)CC2)COC[C@@H]1O CHEMBL5396961 IC50 29.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 31.62 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 31.62 nM
O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL3605057 IC50 36.0 nM
C[C@@H](c1ccccc1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 CHEMBL3884884 IC50 37.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc5ccoc5c4)cnc23)cs1 CHEMBL4526375 IC50 38.0 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 39.81 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 39.81 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@@H]5O)c4)cnn3c2)cn1 CHEMBL4588200 IC50 43.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 49.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 50.12 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 50.12 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 50.12 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 50.12 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 50.12 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 50.12 nM
CC[C@H](C)N1C(=O)C2(CC2)c2cnc(Nc3cccnc3)nc21 CHEMBL3885080 IC50 60.0 nM
C[C@@H](c1ccc(F)cc1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 CHEMBL3884179 IC50 61.0 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 63.1 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 63.1 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 63.1 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4cccnc4)cnc23)cs1 CHEMBL4550262 IC50 70.0 nM
Cn1ccc2ccc(-c3cnc4c(-c5csc(C(=O)NCC(F)(F)F)c5)cnn4c3)cc21 CHEMBL4541288 IC50 74.0 nM
O=C(NCCCCCCNC(=O)NCc1cccnc1)NCc1cccnc1 CHEMBL2003420 pKi 79.43 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 79.43 nM
CC(C)[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3ccccc3)nc21 CHEMBL3883412 IC50 80.0 nM
CC[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3ccc(-c4nnc(C)[nH]4)cc3)nc21 CHEMBL3884116 IC50 80.0 nM
CC[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 CHEMBL3884253 IC50 82.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4cn[nH]c4)cnc23)cs1 CHEMBL4514812 IC50 99.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 100.0 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 pKi 100.0 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 100.0 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 100.0 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 Kd apparent 104.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 105.0 nM
CC[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3ccc(S(C)(=O)=O)cc3)nc21 CHEMBL3885363 IC50 120.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 125.89 nM
CC(C)(O)Cc1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)nn12 CHEMBL1976732 pKi 125.89 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 125.89 nM
OC1CCN(c2ncnc3[nH]cc(-c4ccccc4)c23)CC1 CHEMBL1973395 pKi 125.89 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(Cl)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1987054 pKi 125.89 nM
CCNC(=O)c1cc(-c2cnn3cc(-c4cnn(C)c4)cnc23)cs1 CHEMBL4556844 IC50 129.0 nM
Cc1sc(C(=O)N[C@H]2CCCC(F)(F)[C@H]2N)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 CHEMBL4561857 IC50 130.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 133.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br)C1CCC1 CHEMBL5085430 IC50 137.0 nM
CCc1sc(C(=O)NC2[C@H](N)CCCC2(F)F)cc1-c1cnc2cc(C)cnn12 CHEMBL3648450 IC50 140.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 158.49 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 158.49 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCCO)c(Cl)cc1NC(=O)N2 CHEMBL373598 pKi 158.49 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 158.49 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 158.49 nM
CCC1CC(NS(=O)(=O)C2CC2)CC1c1ncc2cnc3[nH]ccc3n12 CHEMBL1992073 pKi 158.49 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 199.53 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 199.53 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 199.53 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 199.53 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 199.53 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 199.53 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 199.53 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 199.53 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 Kd apparent 204.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 220.0 nM
CC1(C)C(=O)N(C2CCCC2)c2nc(Nc3ccccc3)ncc21 CHEMBL3883637 IC50 226.0 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 251.19 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 251.19 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 251.19 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 251.19 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 300.0 nM
CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3ccccc3)ncc21 CHEMBL3883802 IC50 304.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 306.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 316.23 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 316.23 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 316.23 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCO)c(Cl)cc1NC(=O)N2 CHEMBL413779 pKi 316.23 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12 CHEMBL1082440 pKi 316.23 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 316.23 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 316.23 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 316.23 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 321.0 nM
CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccnc3)ncc21 CHEMBL3883548 IC50 346.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 361.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 384.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 387.0 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 pKi 398.11 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 398.11 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccc(Cl)cc5o4)cc3)c1)CNC2=O CHEMBL2002479 pKi 398.11 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 398.11 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 398.11 nM
COCc1nnn(-c2nonc2N)c1C(=O)NN=C(C)c1ccc(O)cc1O CHEMBL1991180 pKi 398.11 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 398.11 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 398.11 nM
CNC(=O)N1CCN(CCCOc2ccc3c(c2)-c2[nH]nc(-c4ccc(C#N)nc4)c2C3)CC1 CHEMBL2001998 pKi 398.11 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 398.11 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 398.11 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 398.11 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 410.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 417.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 490.0 nM
c1ccc(-c2c[nH]c3ncnc(N4CCCCC4)c23)cc1 CHEMBL1998953 pKi 501.19 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 501.19 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 501.19 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 501.19 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2C2CC2)cc1 CHEMBL1975418 pKi 501.19 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 501.19 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 501.19 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 501.19 nM
CC[C@@](C)(Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(=O)NCC(F)(F)F CHEMBL3039513 Kd apparent 562.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 600.0 nM
CC(C)N1C(=O)C(C)(C)c2cnc(Nc3ccccc3)nc21 CHEMBL3885175 IC50 627.0 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 630.96 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 630.96 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 630.96 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCCN4CCOCC4)cc2-3)cn1 CHEMBL398951 pKi 630.96 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3o2)cc1 CHEMBL2004771 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 630.96 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 630.96 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 630.96 nM
FC(F)(F)Oc1ccc(-c2ccc3[nH]cc(C4=CCNCC4)c3c2)cc1 CHEMBL1987982 pKi 630.96 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 630.96 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 630.96 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 630.96 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 630.96 nM
CC1CCN(C(=O)CC#N)CC1N(C)c1ncnc2[nH]ccc12 CHEMBL234085 pKi 630.96 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1 CHEMBL296586 pKi 630.96 nM
N[C@H]1CCCC(F)(F)C1NC(=O)c1nc(-c2cnc3ccccn23)c(Cl)s1 CHEMBL3648446 IC50 720.0 nM
CC[C@@H](C)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 CHEMBL3883766 IC50 738.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 740.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 770.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682345 pKi 794.33 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 794.33 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 794.33 nM
Cn1cncc1C(OCc1c(-c2ccc(OC(F)(F)F)cc2)cc(C#N)c(=O)n1C)c1ccc(C#N)cc1 CHEMBL127898 pKi 794.33 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 794.33 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 794.33 nM
CC(C)Cc1cc(-c2ccc3[nH]nc(N)c3c2)on1 CHEMBL1966343 pKi 794.33 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 794.33 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 794.33 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 794.33 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 794.33 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 794.33 nM
CN1C(=O)C(C)(C)c2cnc(Nc3cccc(N4CCNCC4)c3)nc21 CHEMBL3885232 IC50 850.0 nM
Brc1cnc(Nc2cccc(CN3CCOCC3)c2)nc1NCCc1c[nH]cn1 CHEMBL5088930 IC50 872.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 1000.0 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 1000.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 1000.0 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)cccc12 CHEMBL1966816 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 1000.0 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 1000.0 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 1000.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 1000.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 1000.0 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 1000.0 nM
CCC(N)(C#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12)CC CHEMBL1983025 pKi 1000.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 1000.0 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 1000.0 nM
CN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1996111 pKi 1000.0 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 1000.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 1000.0 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1cccc(F)c1F CHEMBL1974416 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM