Cn1cc(-c2ccc(=O)n(CC3CN(c4ncc(OCC5CCNCC5)cn4)CCO3)n2)cn1 CHEMBL5184459 IC50 0.019 nM
O=c1ccc(-c2cccnc2)nn1CC1CN(c2ncc(-c3cnn(C4CCNCC4)c3)cn2)CCO1 CHEMBL5174958 IC50 0.035 nM
Fc1cc(F)cc(-c2ccc3nnc(CNc4ccnc5cc(OCCn6cncn6)cnc45)n3n2)c1 CHEMBL3668200 Ki 0.1 nM
COc1ccc2c(OCc3nnc4ncc(-c5ccccc5)nn34)ccnc2c1 CHEMBL3797911 IC50 0.12 nM
CNC(=O)c1ccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cc1F CHEMBL3582305 IC50 0.13 nM
CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F CHEMBL3188267 IC50 0.13 nM
CCN1Cc2c(ccc(F)c2C#N)O[C@@H](C)CNC(=O)c2c(N)nn3ccc1nc23 CHEMBL5095061 IC50 0.14 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncccc5c4)n3n2)cn1 CHEMBL1236107 Kd 0.19 nM
CCN1CCC(n2cc(-c3cnc4ccc5ccc(NS(=O)(=O)N(C)C)cc5c(=O)c4c3)cn2)CC1 CHEMBL1802904 IC50 0.2 nM
Cc1c(O)ccc2nc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)oc12 CHEMBL2032280 IC50 0.2 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 0.2 nM
C/C(=N\NC(N)=O)c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1 CHEMBL3674521 IC50 0.2 nM
N=C(NNC(N)=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3674540 IC50 0.2 nM
C/C(=N\NC(N)=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3674547 IC50 0.2 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c(=O)n(-c2ccccc2)n1C CHEMBL3703197 Kd 0.21 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(-c5ccccc5)nn34)cc2s1 CHEMBL5286745 IC50 0.22 nM
Fc1ccc(-c2cnc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cc1 CHEMBL3797579 IC50 0.24 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 0.27 nM
C/C(=N\NC(N)=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3674515 IC50 0.3 nM
NC(=O)N/N=C/c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3674541 IC50 0.3 nM
COc1ccc2c(OCc3nnc4c(F)cc(-c5cc(C)cs5)cn34)ccnc2c1 CHEMBL3668185 Ki 0.3 nM
CC(c1ccc2ncc(-c3cnn(C)c3)cc2c1)n1nnc2ncc(-c3ccncc3)nc21 CHEMBL4061378 IC50 0.3 nM
CC(c1c(F)cc2ncc(-c3cnn(C)c3)cc2c1F)n1nnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4104884 IC50 0.3 nM
OCCn1cc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1 CHEMBL2001019 EC50 0.3 nM
C[C@@H](Oc1c[nH]c(=O)c(C(=O)NC2CCOCC2)c1)c1c(Cl)ccc(F)c1Cl CHEMBL2376640 IC50 0.32 nM
CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1822792 IC50 0.4 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CCO)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032026 Ki 0.4 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 IC50 0.4 nM
C/C(=N\NC(N)=O)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3674495 IC50 0.4 nM
C/C(=N\NC(N)=O)c1ccc2ncc([C@@H](C)c3ccc4ncccc4c3)n2n1 CHEMBL3674505 IC50 0.4 nM
CC(=O)N/N=C(\C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3674548 IC50 0.4 nM
CC(N=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3651418 IC50 0.4 nM
CC(c1c(F)cc2ncc(-c3cnn(C)c3)cc2c1F)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4097173 IC50 0.4 nM
CC(c1c(F)cc2ncc(-c3cnn(C)c3)cc2c1F)n1nnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL4070258 IC50 0.4 nM
Oc1cccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)c1 CHEMBL3800471 IC50 0.42 nM
Cn1cc(-c2cnc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1 CHEMBL3800420 IC50 0.43 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCc5ccc(C(=O)Nc6ccccc6N)cc5)ccc34)n2)cn1 CHEMBL4214018 IC50 0.44 nM
Cn1cc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cn1 CHEMBL3797914 IC50 0.46 nM
C/C(=N\OC(N)=O)c1ccc2nnc([C@H](C)c3c(F)cc4ncccc4c3F)n2n1 CHEMBL3651416 IC50 0.48 nM
CC(c1cc2cc(-c3cnn(C)c3)cnc2cc1F)n1nnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL4074262 IC50 0.48 nM
c1ccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cc1 CHEMBL3799192 IC50 0.49 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL460472 Ki 0.5 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\C(=O)Nc2cc(C(=O)NCCCN3CCC[C@@H]3CO)cc(Br)c21 CHEMBL1822369 IC50 0.5 nM
C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL2431835 IC50 0.5 nM
FC(F)(c1ccc2ncccc2c1)c1nnc2ncc(-c3ccco3)nn12 CHEMBL3798905 IC50 0.5 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\CNc2cc(C(=O)NCCCCN3CCC[C@H]3CO)cc(Br)c21 CHEMBL3919012 IC50 0.5 nM
C/C(=N\NC(N)=O)c1ccc2nnc(C(C)c3c(F)cc4ncccc4c3F)n2n1 CHEMBL3674524 IC50 0.5 nM
C/C(=N\NC(=O)c1ccncc1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3674550 IC50 0.5 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccccc2)n1C CHEMBL3703196 Kd 0.5 nM
CC(c1ccc2ncc(-c3cnn(C)c3)cc2c1)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4073110 IC50 0.5 nM
CC(c1ccc2ncc(-c3cnn(C)c3)cc2c1)n1nnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL4064183 IC50 0.5 nM
CNC(=O)c1ccc(-c2cnc3nnn(C(C)c4ccc5ncc(-c6cnn(C)c6)cc5c4)c3n2)cc1F CHEMBL4091023 IC50 0.5 nM
CC(c1c(F)cc2ncc(-c3cnn(C)c3)cc2c1F)n1nnc2ncc(-c3ccncc3)nc21 CHEMBL4076438 IC50 0.5 nM
Cn1cc(-c2cnc3cnn(S(=O)(=O)c4cnc5ccc(-c6cnn(C)c6)cn45)c3c2)cn1 CHEMBL4594400 IC50 0.5 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCCCCCCC(=O)NO)ccc34)n2)cn1 CHEMBL4209174 IC50 0.54 nM
C[C@@H](O)CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F CHEMBL3659620 IC50 0.55 nM
CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1Cl CHEMBL3659621 IC50 0.55 nM
Cc1nc([C@H](C)NC(=O)c2ccc(-c3cnc4ncc(Cc5ccc6ncccc6c5)n4n3)cc2Cl)no1 CHEMBL3659622 IC50 0.55 nM
CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cn1 CHEMBL3659623 IC50 0.55 nM
CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1C CHEMBL3659624 IC50 0.55 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL2385195 IC50 0.59 nM
COc1cccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)c1 CHEMBL3800559 IC50 0.59 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5ccccn5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032015 Ki 0.6 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5ccncc5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032014 Ki 0.6 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C5CCOC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2031912 Ki 0.6 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5ccccn5)cc4c(=O)c3c2)cn1 CHEMBL2323775 IC50 0.6 nM
COCCOc1cnc2ccc([C@H](C)n3nnc4ccn(-c5cc(C)ns5)c(=O)c43)cc2c1 CHEMBL2029678 IC50 0.6 nM
CC(c1cc2cc(-c3cnn(C)c3)cnc2cc1F)n1nnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4060354 IC50 0.6 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(OC5CCCCC5)nn34)cc2s1 CHEMBL4551712 Kd 0.6 nM
COc1ccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)cc1 CHEMBL4443952 IC50 0.6 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5)ccc4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL5190707 IC50 0.6 nM
Cc1ccc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL3093579 IC50 0.61 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCc5ccc(/C=C/C(=O)Nc6ccccc6N)nc5)ccc34)n2)cn1 CHEMBL4207111 IC50 0.63 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 0.631 nM
CCCn1cc(-c2cnc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1 CHEMBL3799263 IC50 0.67 nM
O=C(Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1cccn(-c2ccccc2)c1=O CHEMBL3093581 IC50 0.68 nM
C[C@@H](Oc1cc(C(=O)Nc2ccc(C(=O)N3CCN(C)CC3)cc2)nnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL2376648 IC50 0.69 nM
Cn1cc(-c2cnc3ccc4ccc(N)cc4c(=O)c3c2)cn1 CHEMBL1802603 IC50 0.7 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\C(=O)Nc2cc(C(=O)NCN3CCOCC3)cc(Br)c21 CHEMBL1822366 IC50 0.7 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\C(=O)Nc2cc(C(=O)NCCCN3CC[C@@H](O)C3)cc(Br)c21 CHEMBL1822368 IC50 0.7 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5csc(C)n5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032019 Ki 0.7 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5cc(C)on5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032018 Ki 0.7 nM
C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL2431834 IC50 0.7 nM
[2H]C(Nc1cc(C(F)(F)F)cc2ncc(N3CCN(CC([2H])([2H])O)CC3)cc12)c1cccc([N+](=O)[O-])c1 CHEMBL3221134 IC50 0.7 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(I)ccn(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC CHEMBL3260966 IC50 0.7 nM
O=C(NCC1CCCCN1)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582300 IC50 0.7 nM
CN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(-c5cnn(C)c5)cn34)cc21 CHEMBL3818247 IC50 0.7 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\CNc2cc(C(=O)NCCCCN3CC[C@H](O)C3)cc(Br)c21 CHEMBL3889870 IC50 0.7 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\CNc2cc(C(=O)NCCN3CCOCC3)cc(Br)c21 CHEMBL3950207 IC50 0.7 nM
C/C(=N\NC(N)=O)c1ccc2nnc(C(F)(F)c3ccc4ncccc4c3)n2n1 CHEMBL3674508 IC50 0.7 nM
Cc1csc(-c2ccc3nnc(Cc4ccc5ncccc5c4)n3n2)c1 CHEMBL3668198 Ki 0.7 nM
CC(c1ccc2ncc(-c3cnn(C)c3)cc2c1)n1nnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4070051 IC50 0.7 nM
CC(c1cc2cc(-c3cnn(C)c3)cnc2cc1F)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4083235 IC50 0.7 nM
CC(c1cc2cc(-c3cnn(C)c3)cnc2cc1F)n1nnc2ncc(-c3ccncc3)nc21 CHEMBL4068290 IC50 0.7 nM
Cc1cc(C)cc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)c1 CHEMBL4578460 IC50 0.7 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCCCOc5ccc(C(=O)Nc6ccccc6N)nc5)ccc34)n2)cn1 CHEMBL4204833 IC50 0.71 nM
Cc1c(OCC(O)CN2CCN(C)CC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4282387 IC50 0.71 nM
O=[N+]([O-])c1cccc(CNc2cc(C(F)(F)F)cc3ncc(N4CCOCC4)cc23)c1 CHEMBL1766539 IC50 0.72 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCCCCCC(=O)NO)ccc34)n2)cn1 CHEMBL4204308 IC50 0.73 nM
C[C@@H]1CN(C(=O)c2ccc(NC(=O)c3cc(O[C@H](C)c4c(Cl)ccc(F)c4Cl)c(N)nn3)cc2)C[C@H](C)N1 CHEMBL4113131 IC50 0.74 nM
CCOC(=O)CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL1766544 IC50 0.77 nM
Cc1ccc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL3093582 IC50 0.77 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5cccnc5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032016 Ki 0.8 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(O)CN)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2032031 Ki 0.8 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032029 Ki 0.8 nM
C/C(=N\N(C)C(N)=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3674535 IC50 0.8 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4873571 IC50 0.8 nM
CS(=O)(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL1766543 IC50 0.82 nM
O=[N+]([O-])c1cccc(CNc2cc(C(F)(F)F)cc3ncc(N4CCN(S(=O)(=O)C5CC5)CC4)cc23)c1 CHEMBL1766542 IC50 0.84 nM
O=c1ccc(-n2ccc3ccc(F)cc32)nn1CCOc1ccnc2cc(OCCCN3CCOCC3)ccc12 CHEMBL3417489 IC50 0.84 nM
C=C(C)Cn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL2032023 Ki 0.9 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C5CCCO5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2031911 Ki 0.9 nM
CC[C@H](O)Cn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL2029375 Ki 0.9 nM
[2H]C(Nc1cc(C(F)(F)F)cc2ncc(N3CCN(C)CC3)cc12)c1cccc([N+](=O)[O-])c1 CHEMBL3221131 IC50 0.9 nM
CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1 CHEMBL3260967 IC50 0.9 nM
O=C(NC1CCCNC1)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582301 IC50 0.9 nM
C/C(=N\n1cc(O)[nH]c1=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3923620 IC50 0.9 nM
COc1cnc2c(NCc3nnc4ncc(-c5ccccc5)nn34)ccnc2c1 CHEMBL3668132 Ki 0.9 nM
CNC(=O)c1ccc(-c2cnc3nnn(C(C)c4c(F)cc5ncc(-c6cnn(C)c6)cc5c4F)c3n2)cc1F CHEMBL4075149 IC50 0.9 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4082724 IC50 0.9 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(-c5ccc(F)cc5)nn34)cc2s1 CHEMBL4461070 Kd 0.9 nM
CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL1766528 IC50 0.93 nM
CC(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL1766529 IC50 0.95 nM
Cn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1 CHEMBL2133806 IC50 0.95 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCCCCC(=O)NO)ccc34)n2)cn1 CHEMBL4205747 IC50 0.96 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCCCCCC(=O)Nc5ccccc5N)ccc34)n2)cn1 CHEMBL4209005 IC50 0.96 nM
COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC CHEMBL404881 Ki 1.0 nM
Cc1csc(-c2ccc3nnc(Cc4ccc(O)cc4)n3n2)c1 CHEMBL497118 IC50 1.0 nM
CNC(=O)c1ccc(-c2ccc3nnc(Cc4ccc(O)cc4)n3n2)cc1Cl CHEMBL494985 IC50 1.0 nM
C#Cc1c(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)ccnc1N CHEMBL462622 IC50 1.0 nM
Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1Cl CHEMBL462624 IC50 1.0 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL460465 Ki 1.0 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL518174 Ki 1.0 nM
CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL460466 Ki 1.0 nM
CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(CC(F)CO)c4)cc3c(=O)c2c1 CHEMBL1802835 IC50 1.0 nM
CN1CCN(CCCNC(=O)c2cc(Br)c3c(c2)NC(=O)/C3=N\NC(=O)Cc2ccc3c(c2)CCO3)CC1 CHEMBL1823128 IC50 1.0 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\C(=O)Nc2cc(C(=O)NCCCN3CC[C@H](O)C3)cc(Br)c21 CHEMBL1823252 IC50 1.0 nM
CN(C)CCNC(=O)c1cc(Br)c2c(c1)NC(=O)/C2=N\NC(=O)Cc1ccc2c(c1)CCO2 CHEMBL1822791 IC50 1.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC CHEMBL2031893 Ki 1.0 nM
COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c43)cc2c1 CHEMBL2029563 IC50 1.0 nM
COc1cnc2ccc([C@H](C)n3nnc4ccn(-c5cc(C)ns5)c(=O)c43)cc2c1 CHEMBL2029565 IC50 1.0 nM
COCCOc1cnc2ccc([C@H](C)n3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c43)cc2c1 CHEMBL2029686 IC50 1.0 nM
c1cnc2ccc(Cn3nnc4ncc(-c5cn[nH]c5)nc43)cc2c1 CHEMBL2170818 Ki 1.0 nM
Cn1cc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1 CHEMBL2170816 IC50 1.0 nM
O=c1c2cc(CS(=O)(=O)NCc3ccccn3)ccc2ccc2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL2323783 IC50 1.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5cccnn5)cc4c(=O)c3c2)cn1 CHEMBL2323770 IC50 1.0 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c12 CHEMBL3394472 IC50 1.0 nM
N#Cc1cccc(-c2ccc(=O)n(Cc3cccc(-c4ncc(OCCN5CCOCC5)cn4)c3)n2)c1 CHEMBL3402761 IC50 1.0 nM
COCCOc1cnc2ccc([C@H](C)c3nnc4c(F)cc(-c5cc(C)no5)cn34)cc2c1 CHEMBL3414926 IC50 1.0 nM
COc1cnc2ccc([C@H](C)c3nnc4c(F)cc(-c5cn(C)cn5)cn34)cc2c1 CHEMBL3414922 IC50 1.0 nM
Cn1ccnc1-c1cc2c(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)ccnc2s1 CHEMBL3764474 IC50 1.0 nM
COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(-c5cc(C)no5)cn34)c(=O)c2c1 CHEMBL3785199 IC50 1.0 nM
COc1cnc2ccn([C@H](C)c3nnc4c(F)cc(-c5cnn(C)c5)cn34)c(=O)c2c1 CHEMBL3787004 IC50 1.0 nM
COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(-c5cnn(C)c5)cn34)c(=O)c2c1 CHEMBL3785909 IC50 1.0 nM
Cn1cc(-c2ccc3c(OCCn4c(=O)oc5cc(-c6cnn(C)c6)ccc54)ccnc3c2)cn1 CHEMBL3786898 IC50 1.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1 CHEMBL3989914 IC50 1.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL3674478 IC50 1.0 nM
C/C(=N\N(C)C(N)=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL3674485 IC50 1.0 nM
C/C(=N\n1cc(O)[nH]c1=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL3974451 IC50 1.0 nM
C/C(=N\NC(N)=O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1 CHEMBL3674512 IC50 1.0 nM
C/C(=N\N1CCOC1=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL4114798 IC50 1.0 nM
COC(=O)N/N=C(\C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3674549 IC50 1.0 nM
C/C(=N\NC(=O)c1cccnc1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3674553 IC50 1.0 nM
CC1=NC(C)=C(C#N)C(c2ccc3[nH]nc(OCCOC(C)C)c3c2)C1C#N CHEMBL3648323 IC50 1.0 nM
[C-]#[N+]C1C(C)=NC2=C(C(=O)OC2)C1c1ccc2n[nH]c(C)c2c1 CHEMBL3685752 IC50 1.0 nM
CN1CCC(Nc2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3703945 IC50 1.0 nM
CN(C)[C@H]1CCN(c2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)C1 CHEMBL3703950 IC50 1.0 nM
C[C@@H]1CN(c2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)C[C@H](C)N1 CHEMBL3703976 IC50 1.0 nM
COC1CCN(c2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3703980 IC50 1.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NCCO)cc5c4)n3c2)cn1 CHEMBL3703988 IC50 1.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(N6CCC(F)(F)CC6)cc5c4)n3c2)cn1 CHEMBL3703999 IC50 1.0 nM
[C-]#[N+]C1=C(C)Nc2oncc2C1c1ccc2[nH]nc(OC)c2c1 CHEMBL3678510 IC50 1.0 nM
N#Cc1cc(-c2cnc3nnn(CC4CN(c5ncc(-c6cnn(CCO)c6)cn5)CCO4)c3n2)ccc1F CHEMBL3959443 IC50 1.0 nM
CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C(F)(F)F)N1 CHEMBL3938140 IC50 1.0 nM
CN1CCC(COc2cnc(-c3cccc(Cn4nc(-c5cccc(C#N)c5)ccc4=O)c3)nc2)CC1 CHEMBL3402762 Kd apparent 1.0 nM
CNC(=O)c1ccc(-c2cnc3nnn(C(C)c4cc5cc(-c6cnn(C)c6)cnc5cc4F)c3n2)cc1F CHEMBL4092293 IC50 1.0 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCCCC(=O)NO)ccc34)n2)cn1 CHEMBL4209562 IC50 1.0 nM
CC(=O)CCCCCOc1ccc2c(OCCn3nc(-c4cnn(C)c4)ccc3=O)ccnc2c1 CHEMBL4208236 IC50 1.0 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CC5)nn34)cc2s1 CHEMBL4513820 IC50 1.0 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CCOCC5)nn34)cc2s1 CHEMBL4593634 IC50 1.0 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CCCCC5)nn34)cc2s1 CHEMBL4466644 IC50 1.0 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4cccc(Cl)c4)c3=O)cc2F)c1Cl CHEMBL4539641 IC50 1.0 nM
CC(c1c(F)cc2ncccc2c1F)n1cnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4542192 EC50 1.0 nM
CC(c1c(F)cc2ncccc2c1F)n1cnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL4483314 EC50 1.0 nM
CCN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL1766530 IC50 1.01 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL2385176 IC50 1.03 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343366 IC50 1.04 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL2385175 IC50 1.05 nM
Cc1cc(=O)n(-c2ccc(F)cc2)nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL4066684 IC50 1.06 nM
C[C@H](c1cccc(-c2ncc(OCC3CCN(C)CC3)cn2)c1)n1cc(-c2cc(C#N)ccn2)cc(F)c1=O CHEMBL5408530 IC50 1.09 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL460468 Ki 1.1 nM
CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1 CHEMBL2032022 Ki 1.1 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C5CCOCC5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032013 Ki 1.1 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5OC)cn4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3931223 IC50 1.1 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCc5ccc(/C=C/C(=O)Nc6ccccc6N)cc5)ccc34)n2)cn1 CHEMBL4207710 IC50 1.1 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(C)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3116440 IC50 1.15 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5cnccn5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2032017 Ki 1.2 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C5CCOCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2031913 Ki 1.2 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2031901 Ki 1.2 nM
C[C@H](N)C(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3220878 IC50 1.2 nM
C[C@@H](N)C(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3220879 IC50 1.2 nM
CCCn1cc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cn1 CHEMBL3800295 IC50 1.2 nM
Clc1ccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cc1Cl CHEMBL3800427 IC50 1.2 nM
CC(N=O)c1ccc2nnc([C@@H](C)c3c(F)cc4ncccc4c3F)n2n1 CHEMBL3651414 IC50 1.2 nM
COc1cnc2c(NCc3nnc4ccc(-c5cc(C)cs5)nn34)ccnc2c1 CHEMBL3668165 Ki 1.2 nM
CNC(=O)CCCCCOc1ccc2c(OCCn3nc(-c4cnn(C)c4)ccc3=O)ccnc2c1 CHEMBL4203363 IC50 1.2 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(Cl)c5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3780676 IC50 1.21 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385202 IC50 1.22 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccccc5Cl)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4072335 IC50 1.22 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccc(-c2ccccc2)[n+]1[O-] CHEMBL459875 IC50 1.3 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)=O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL461293 Ki 1.3 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(O)C(C)C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2032030 Ki 1.3 nM
Cc1ccc(Cl)c2c1NC(=O)/C2=N\NC(=O)[C@@H](C)c1ccc(O)cc1 CHEMBL2170969 Ki 1.3 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 IC50 1.3 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c2cc1OC CHEMBL489326 IC50 1.3 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(N)cc5c4)n3c2)cn1 CHEMBL3703990 IC50 1.3 nM
CC(c1ccc2ncc(-c3ccc(F)cc3)cc2c1)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4093803 IC50 1.3 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(-c5ccc(C(=O)Nc6ccccc6N)s5)ccc34)n2)cn1 CHEMBL4209189 IC50 1.3 nM
CC(c1c(F)cc2ncccc2c1F)n1cnc2ncc(-c3cnc4ccccc4c3)nc21 CHEMBL4524262 EC50 1.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5cccc(Cl)c5)nc5ccccc45)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2392959 IC50 1.32 nM
C[C@@H](c1cc2cccnc2cc1F)n1cnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4570217 EC50 1.32 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL5273665 IC50 1.35 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccc(C)cc5)ccn4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL2435999 IC50 1.39 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL2031907 Ki 1.4 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(CN)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2031903 Ki 1.4 nM
COCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1 CHEMBL2032027 Ki 1.4 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CCO)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2032025 Ki 1.4 nM
COc1cc2c(Oc3ccc(NC(=O)N/N=C/c4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2419669 IC50 1.4 nM
FC(F)(c1ccc2ncccc2c1)c1nnc2ncc(-c3cccs3)nn12 CHEMBL3797871 IC50 1.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4[nH]c(=O)n(-c5ccccc5Cl)c4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3594105 IC50 1.42 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(C5CCCCC5)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4472885 IC50 1.42 nM
C[C@@H](c1cc2cccnc2cc1F)n1cnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4068255 EC50 1.45 nM
NC1CCC(=Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 CHEMBL254086 IC50 1.5 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2031906 Ki 1.5 nM
CC(c1cc2cc(-c3ccc(F)cc3)cnc2cc1F)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4094716 IC50 1.5 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCCCCCS)ccc34)n2)cn1 CHEMBL4218410 IC50 1.5 nM
Cc1cc2ccnc(Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)c2c(=O)n1-c1ccc(F)cc1 CHEMBL4442365 IC50 1.5 nM
C=CCc1cccc(/C=N/NC(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCCCC5)c(OC)cc34)c(F)c2)c1O CHEMBL3764279 IC50 1.54 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5)c4C)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343364 IC50 1.56 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3946811 IC50 1.57 nM
CN(C)CCCNC(=O)c1cc(Br)c2c(c1)NC(=O)/C2=N\NC(=O)Cc1ccc2occc2c1 CHEMBL1822371 IC50 1.6 nM
CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1 CHEMBL2032021 Ki 1.6 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2cccc(-c3ccccn3)c2o1 CHEMBL2032155 IC50 1.6 nM
C[C@H](O)C(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3220880 IC50 1.6 nM
[2H]C(Nc1cc(C(F)(F)F)cc2ncc(N3CCN(C(C)=O)CC3)cc12)c1cccc([N+](=O)[O-])c1 CHEMBL3221132 IC50 1.6 nM
COc1ccc2c(OCc3nnc4ccc(-c5cc(C)ns5)nn34)ccnc2c1 CHEMBL567908 Ki 1.6 nM
CC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4551781 EC50 1.6 nM
CC(c1c(F)cc2ncccc2c1F)n1cnc2ncc(-c3ccncc3)nc21 CHEMBL4585798 EC50 1.6 nM
CCC(c1ccc2ncccc2c1F)n1cnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4560823 EC50 1.6 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3309402 IC50 1.63 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(C)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3116243 IC50 1.64 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385201 IC50 1.65 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5cccc(Cl)c5)nc5ccc(F)cc45)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2392819 IC50 1.65 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1nnn(-c2ccc(F)cc2)c1C(F)(F)F CHEMBL3774451 IC50 1.68 nM
COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(c5ccccc5)C4=O)cc3F)c2cc1OC CHEMBL573761 Ki 1.7 nM
O=C(Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c(F)c1)c1cccn(-c2ccccc2)c1=O CHEMBL3093583 IC50 1.7 nM
CCCNC(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3221108 IC50 1.7 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(OC)ccn(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC CHEMBL3260968 IC50 1.7 nM
CN1CCN(CCOc2cnc(-c3cccc(Cn4nc(-n5ccc6ccc(F)cc65)ccc4=O)c3)nc2)CC1 CHEMBL3417485 IC50 1.7 nM
Nc1nccc(Oc2ccc(NC(=O)c3c[nH]cc(-c4ccc(F)cc4)c3=O)cc2F)c1Cl CHEMBL2143592 IC50 1.7 nM
C[C@H](Oc1cc(-c2cn(C3CCNCC3)nn2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL3647531 IC50 1.7 nM
COc1cnc2c(OCc3cnc4ccc(-c5cc(F)c(F)c(F)c5)nn34)ccnc2c1 CHEMBL3668136 Ki 1.7 nM
CC(c1cc2cc(-c3ccc(F)cc3)cnc2cc1F)n1nnc2ncc(-c3ccncc3)nc21 CHEMBL4078192 IC50 1.7 nM
Cc1ccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)cc1C CHEMBL4552325 IC50 1.7 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4ccc(Cl)c(Cl)c4)c3=O)cc2F)c1Cl CHEMBL4476854 IC50 1.7 nM
CC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4589643 EC50 1.7 nM
Nc1ncnc2[nH]cc(-c3cc(F)c(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3F)c12 CHEMBL4869472 IC50 1.7 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(Cl)c5ccccc5n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3781716 IC50 1.75 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O CHEMBL509101 IC50 1.8 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccc(-c2ccc(F)cc2)[n+]1[O-] CHEMBL459876 IC50 1.8 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL3394469 IC50 1.8 nM
N#Cc1cccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)c1 CHEMBL3582285 IC50 1.8 nM
CO/N=C(\C)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3648227 IC50 1.8 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4ccccc4)c3=O)cc2F)c1Cl CHEMBL4582423 IC50 1.8 nM
CC(c1c(F)cc2ncccc2c1F)n1cnc2ncc(-c3ccccc3)nc21 CHEMBL4561132 EC50 1.8 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3343374 IC50 1.81 nM
COc1cc2c(Oc3ccc(CC(=O)N/N=C/c4ccc(C(F)(F)F)cc4)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3339360 IC50 1.86 nM
C[C@@H](Oc1cc(-c2ccc3c(c2)NC(=O)C32CCN(C)CC2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL3091723 IC50 1.87 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(-c2ccccc2)c1=O CHEMBL451809 IC50 1.9 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC CHEMBL2031900 Ki 1.9 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2032028 Ki 1.9 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C(C)CN(C(C)=O)CC3)ncc1Cl CHEMBL3263982 IC50 1.9 nM
CC1=[N+](c2ccccc2)C(=O)C(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c(F)c2)C=C1 CHEMBL3765306 IC50 1.9 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1)c1nc2ccccc2n(-c2ccc(F)cc2)c1=O CHEMBL5207345 IC50 1.91 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cc2cccnc2n(-c2ccc(F)cc2)c1=O CHEMBL4289577 IC50 1.92 nM
C[C@H](c1cc2cccnc2cc1F)n1cnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4581168 EC50 1.94 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3309410 IC50 1.98 nM
COc1cc2c(Oc3ccc(NC(=O)NS(=O)(=O)Cc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL4533153 IC50 1.98 nM
C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL3334567 pIC50 1.995 nM
Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1 CHEMBL258240 IC50 2.0 nM
COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3)c2cc1OC CHEMBL205372 Ki 2.0 nM
C#Cc1c(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)ccnc1N CHEMBL502531 IC50 2.0 nM
O=C(Cc1ccc(F)cc1)NC(=O)Nc1ccc(Oc2ccnc3[nH]c(-c4cccnc4)cc23)c(F)c1 CHEMBL525260 IC50 2.0 nM
O=C(Cc1ccc(F)cc1)NC(=O)Nc1ccc(Oc2ccnc3[nH]cc(-c4cccnc4)c23)c(F)c1 CHEMBL524364 IC50 2.0 nM
Oc1ccc(Cc2nnc3ccc(-c4cccs4)nn23)cc1 CHEMBL523386 IC50 2.0 nM
Cc1cc(-c2ccc3nnc(Cc4ccc(O)cc4)n3n2)sn1 CHEMBL523413 IC50 2.0 nM
CN([C@H]1CCOC1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1802914 IC50 2.0 nM
CN(Cc1cnccn1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1802909 IC50 2.0 nM
CNS(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1802907 IC50 2.0 nM
CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(CC(F)CN5CCCC5)c4)cc3c(=O)c2c1 CHEMBL1802903 IC50 2.0 nM
CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(CC(=O)N5CCOCC5)c4)cc3c(=O)c2c1 CHEMBL1802831 IC50 2.0 nM
CCCn1cc(-c2cnc3ccc4ccc(NS(=O)(=O)N(C)C)cc4c(=O)c3c2)cn1 CHEMBL1802830 IC50 2.0 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\C(=O)Nc2cc(C(=O)NCCCN3CCC(O)CC3)cc(Br)c21 CHEMBL1822370 IC50 2.0 nM
Cn1cc(-c2ccc3nnc(Cc4cccc5c(=O)[nH]ccc45)n3n2)cn1 CHEMBL1922404 IC50 2.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5cnn(CCO)c5)nn34)cccc12 CHEMBL1922406 IC50 2.0 nM
Cc1cc(-n2ccc3nnn([C@@H](C)c4ccc5ncccc5c4)c3c2=O)sn1 CHEMBL2029564 IC50 2.0 nM
COCCOc1cnc2ccc([C@H](C)n3nnc4ccn(-c5cccs5)c(=O)c43)cc2c1 CHEMBL2029680 IC50 2.0 nM
COCCOc1cnc2ccc([C@H](C)n3nnc4ccn(-c5ccc(F)c(F)c5)c(=O)c43)cc2c1 CHEMBL2029687 IC50 2.0 nM
CNc1snc(SCc2nnc3ncc(-c4ccc(F)cc4)nn23)c1C(N)=O CHEMBL2170966 Ki 2.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5cccc[n+]5[O-])cc4c(=O)c3c2)cn1 CHEMBL2323777 IC50 2.0 nM
N#Cc1cccc(-c2ccc(=O)n(C[C@@H]3CN(c4ncc(C5=CCN(CCO)CC5)cn4)CCO3)n2)c1 CHEMBL3335781 IC50 2.0 nM
COc1cnc2ccc([C@H](C)c3nnc4c(F)cc(-c5cc(C)no5)cn34)cc2c1 CHEMBL3414925 IC50 2.0 nM
COc1cnc2ccc([C@H](C)c3nnc4c(F)cc(-c5cnn(C)c5)cn34)cc2c1 CHEMBL3414923 IC50 2.0 nM
COc1cnc2ccc([C@@](C)(F)c3nnc4c(F)cc(-c5cc(C)no5)cn34)cc2c1 CHEMBL3414918 IC50 2.0 nM
COc1cnc2ccc(C(F)(F)c3nnc4c(F)cc(-c5cscn5)cn34)cc2c1 CHEMBL3414914 IC50 2.0 nM
O=C(NCCN1CCOCC1)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582297 IC50 2.0 nM
COc1cnc2ccn([C@H](C)c3nnc4c(F)cc(-c5cc(C)no5)cn34)c(=O)c2c1 CHEMBL3786314 IC50 2.0 nM
COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(-c5cc(C)no5)cn34)c(=O)c2c1 CHEMBL3785094 IC50 2.0 nM
C[C@H](c1nnc2c(F)cc(-c3cnn(C)c3)cn12)n1ccc2ncccc2c1=O CHEMBL3787109 IC50 2.0 nM
O=[N+]([O-])c1cccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)c1 CHEMBL3798623 IC50 2.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1 CHEMBL3674494 IC50 2.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(C(O)c3c(F)cc4ncccc4c3F)n2n1 CHEMBL3674500 IC50 2.0 nM
[C-]#[N+]C1=C2COCCN2C2=C(C(=O)OC2)C1c1ccc2[nH]nc(C)c2c1 CHEMBL3685756 IC50 2.0 nM
[C-]#[N+]C1=C(c2ccc(F)cc2F)N=C2COC(=O)C2C1c1ccc2n[nH]c(C)c2c1 CHEMBL3685759 IC50 2.0 nM
CN(C)[C@H]1CCN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)C1 CHEMBL3703940 IC50 2.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(N6CCC(N7CCCC7)CC6)cc5c4)n3c2)cn1 CHEMBL3703951 IC50 2.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(N)CC6)cc5c4)n3c2)cn1 CHEMBL3703956 IC50 2.0 nM
CN1CCN(c2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3703959 IC50 2.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(N7CCCCC7)CC6)cc5c4)n3c2)cn1 CHEMBL3703964 IC50 2.0 nM
CC1CN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CC(C)O1 CHEMBL3703973 IC50 2.0 nM
CC1CN(c2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)CC(C)O1 CHEMBL3703974 IC50 2.0 nM
COC1CCN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3703979 IC50 2.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(NC6CCOC6)cc5c4)n3c2)cn1 CHEMBL3703987 IC50 2.0 nM
c1cc2ncc(N3CCOCC3)cc2cc1Sc1nnc2ccc(-c3cn[nH]c3)cn12 CHEMBL3703992 IC50 2.0 nM
C/C(=N\OCCO)c1ccc2nnc(Sc3ccc4ncc(N5CCOCC5)cc4c3)n2c1 CHEMBL3704009 IC50 2.0 nM
COc1ccc2c(OCc3nnc4c(F)cc(-c5cc(C)ns5)cn34)ccnc2c1 CHEMBL3668146 Ki 2.0 nM
COc1cnc2c(NCc3nnc4ccc(-c5ccc6ncsc6c5)nn34)ccnc2c1 CHEMBL3668187 Ki 2.0 nM
[C-]#[N+]C1=C(C)Nc2oncc2C1c1ccc2[nH]nc(C)c2c1 CHEMBL3678509 IC50 2.0 nM
CC1=C(C#N)C(c2cccc3[nH]ncc23)C(C#N)=C(C)N1 CHEMBL3980042 IC50 2.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6cnn(C7CCNCC7)c6)cn5)CCO4)c3n2)cn1 CHEMBL3915010 IC50 2.0 nM
CN1CCC(c2cnc(N3CCO[C@H](Cn4nnc5ncc(-c6cnn(C)c6)nc54)C3)nc2)CC1 CHEMBL3912793 IC50 2.0 nM
N#Cc1cccc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(C6=CCN(CCO)CC6)cn5)CCO4)c3n2)c1 CHEMBL3894426 IC50 2.0 nM
Cn1cc(-c2cnc(N3CCO[C@H](Cn4nnc5ncc(-c6ccc(F)c(C#N)c6)nc54)C3)nc2)cn1 CHEMBL3892800 IC50 2.0 nM
N#Cc1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(C6=CCNCC6)cn5)CCO4)c3n2)ccc1F CHEMBL3959366 IC50 2.0 nM
N#Cc1cccc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6cnn(CCO)c6)cn5)CCO4)c3n2)c1 CHEMBL3890371 IC50 2.0 nM
Cn1cc(-c2cnc3nnn(CC4CCCN(c5ncc(-c6cnn(CCO)c6)cn5)C4)c3n2)cn1 CHEMBL3941864 IC50 2.0 nM
Cn1cc(-c2cnc3nnn(CC4CCCN(c5ncc(-c6cnn(C7CCNCC7)c6)cn5)C4)c3n2)cn1 CHEMBL3919372 IC50 2.0 nM
CN1CCN(Cc2ccc(-c3cnc(N4CCOC(Cn5nnc6ncc(-c7ccc(F)c(C#N)c7)nc65)C4)nc3)cc2F)CC1 CHEMBL3906002 IC50 2.0 nM
CN1CCN(Cc2ccc(-c3cnc(N4CCOC(Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2F)CC1 CHEMBL3933163 IC50 2.0 nM
CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C(F)F)N1 CHEMBL3984362 IC50 2.0 nM
O=C(CCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(-c5ccc(F)cc5)nn34)cc2s1 CHEMBL4470877 IC50 2.0 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(Oc5ccccc5)nn34)cc2s1 CHEMBL4541666 IC50 2.0 nM
CCN1CCC(CCNC(=O)Nc2nc3ccc(Sc4nnc5ccc(-c6cccs6)nn45)cc3s2)CC1 CHEMBL4527749 IC50 2.0 nM
COc1ccc2c(OCc3nnc4sc(-c5cnn(C)c5)nn34)ccnc2c1 CHEMBL4249147 IC50 2.02 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3309566 IC50 2.03 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3343382 IC50 2.04 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5OC(F)(F)F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3947425 IC50 2.08 nM
C[C@@H](Oc1cc(-c2cnn(C3CC4(CCCNC4)C3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4114311 IC50 2.09 nM
CCNC(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3221107 IC50 2.1 nM
Cc1c(OCC(O)CN2CCC(O)CC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4277848 IC50 2.1 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4ccc(F)c(Cl)c4)c3=O)cc2F)c1Cl CHEMBL4437901 IC50 2.1 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5)c4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3343372 IC50 2.13 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3290931 IC50 2.15 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(C)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3116222 IC50 2.16 nM
O=[N+]([O-])c1cccc(CNc2cc(C(F)(F)F)cc3ncc(N4CCNCC4)cc23)c1 CHEMBL1766532 IC50 2.2 nM
C/C(=N\OCCO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3648242 IC50 2.2 nM
CNC(=O)c1ccc(-c2ccc3nnc(COc4ccnc5cc(OC)ccc45)n3c2)s1 CHEMBL3668142 Ki 2.2 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)N(c5ccccc5C(F)(F)F)N=C4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3949465 IC50 2.2 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cc2cccnc2n(-c2ccc(Cl)cc2)c1=O CHEMBL4281698 IC50 2.23 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5Cl)nn4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3823520 IC50 2.27 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cn(-c2ccc(Cl)c(F)c2)cc(-c2ccc(F)cc2)c1=O CHEMBL503901 IC50 2.3 nM
COc1ccc(-n2cc(C(=O)Nc3ccc(Oc4ccnc5[nH]ccc45)c(F)c3)c(=O)c(-c3ccc(F)cc3)c2)cc1F CHEMBL503139 IC50 2.3 nM
CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL2032020 Ki 2.3 nM
CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C CHEMBL2031905 Ki 2.3 nM
Cn1cc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL3093585 IC50 2.3 nM
O=C(/C=C/[C@@H]1CCCN1)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3220881 IC50 2.3 nM
O=c1ccc(-n2ccc3ccc(F)cc32)nn1Cc1cccc(-c2ncc(OCCN3CCOCC3)cn2)c1 CHEMBL3417484 IC50 2.3 nM
c1csc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)c1 CHEMBL3797547 IC50 2.3 nM
c1cnc2ccc(Cc3nnc4ncc(-c5cnc6ccccc6c5)nn34)cc2c1 CHEMBL3798174 IC50 2.3 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4ccc(Cl)c(C(F)(F)F)c4)c3=O)cc2F)c1Cl CHEMBL4467949 IC50 2.3 nM
CNC(=O)c1ccc(-c2cnc3ncn(C(C)c4cc5cccnc5cc4F)c3n2)cc1F CHEMBL4554510 EC50 2.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(C5CCCCC5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4543837 IC50 2.34 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5c(C)cccc5C)C4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3116441 IC50 2.35 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4095304 IC50 2.35 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc5cccnc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4279457 IC50 2.36 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)c(Cl)c5)C4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3116218 IC50 2.38 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3343390 IC50 2.38 nM
CCc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OC CHEMBL2031896 Ki 2.4 nM
CCC(=O)N1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2C(C)C1 CHEMBL3263981 IC50 2.4 nM
CN(C)CCNC(=O)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582298 IC50 2.4 nM
CO/N=C(\C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3648241 IC50 2.4 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)c(=O)n(-c2ccccc2)n1C CHEMBL3703194 Kd 2.4 nM
COc1ccc2c(OCc3nnc4c(F)cc(-c5cnc(C)s5)cn34)ccnc2c1 CHEMBL3668147 Ki 2.4 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc6c(c5)CCC(=O)N6)nn34)ccnc2c1 CHEMBL3668169 Ki 2.4 nM
Cc1cc2ccnc(Nc3ccc(Oc4ccnc(N)c4I)c(F)c3)c2c(=O)n1-c1ccc(F)cc1 CHEMBL4449612 IC50 2.4 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4cc(Cl)cc(Cl)c4)c3=O)cc2F)c1Cl CHEMBL4458142 IC50 2.4 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4ccc(F)c(F)c4)c3=O)cc2F)c1Cl CHEMBL4461741 IC50 2.4 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnc21 CHEMBL4866647 IC50 2.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4779315 IC50 2.43 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)c(F)c5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3343399 IC50 2.47 nM
CC(NC/N=C/c1cnn(C)c1)c1ccc2ncccc2c1 CHEMBL4558786 EC50 2.49 nM
COc1cc2nccc(Oc3ccc(NC(=O)[C@@H](OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4740664 IC50 2.49 nM
O=C(Nc1cccc(CC(=O)N2CCC(c3cc(Cl)ccc3Cl)=N2)c1)OCCCN1CCOCC1 CHEMBL1823478 IC50 2.5 nM
Clc1ccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cc1 CHEMBL3797307 IC50 2.5 nM
C/C(=N\OCCO)c1ccc2ncc([C@@H](C)c3c(F)cc4ncccc4c3F)n2n1 CHEMBL3648231 IC50 2.5 nM
C/C(=N\OCCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3651397 IC50 2.5 nM
Cc1c(OCC(O)CN2CCOCC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4285792 IC50 2.5 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O CHEMBL4455682 IC50 2.5 nM
COc1cccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)c1 CHEMBL4468577 IC50 2.5 nM
CCC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4527506 EC50 2.5 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)c(F)c5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3343377 IC50 2.54 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(Cc5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL4453837 IC50 2.56 nM
COc1cc2nccc(Oc3ccc(NC(=O)[C@H](OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4761612 IC50 2.56 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(C)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3116444 IC50 2.58 nM
Nc1nccc(Oc2ccc(NC(=O)c3c(OCCO)ccn(-c4ccc(F)cc4)c3=O)cc2F)c1Cl CHEMBL461583 IC50 2.6 nM
CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C5CCNCC5)c4)cc3c(=O)c2c1 CHEMBL1802917 IC50 2.6 nM
CN(C)C/C=C/C(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3220882 IC50 2.6 nM
COc1cnc2ccc([C@H](C)c3nnc4ccc(-c5ccccc5)nn34)cc2c1 CHEMBL3668153 Ki 2.6 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc6c(c5)OCCO6)nn34)ccnc2c1 CHEMBL3668176 Ki 2.6 nM
CC(c1ccc2ncc(-c3ccc(F)cc3)cc2c1)n1nnc2ncc(-c3ccncc3)nc21 CHEMBL4072776 IC50 2.6 nM
CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL460702 IC50 2.6 nM
[2H]c1ccc2cc(C(F)(F)c3nnc4ccc(-c5cnn(C)c5)nn34)ccc2n1 CHEMBL5275126 IC50 2.6 nM
CCCNC(=O)c1cc(Oc2ccc(NC(=O)c3cc4cccnc4n(-c4ccc(F)cc4)c3=O)cc2)ccn1 CHEMBL4204920 IC50 2.61 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2385188 IC50 2.64 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccc(F)cc5)nc5ccccc45)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2392958 IC50 2.64 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(C)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3116230 IC50 2.68 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3116442 IC50 2.68 nM
Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1C#CCO CHEMBL518656 IC50 2.7 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL445799 Ki 2.7 nM
CN1CCN(c2cnc3cc(C(F)(F)F)cc(OCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL1766541 IC50 2.7 nM
CN(C)CCCOc1cnc(-c2cccc(Cn3nc(-c4cc(F)cc(F)c4)ccc3=O)c2)nc1 CHEMBL3402756 IC50 2.7 nM
Fc1cc(F)cc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)c1 CHEMBL3582286 IC50 2.7 nM
O=C(Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1)C1CC1 CHEMBL3545365 IC50 2.7 nM
COc1cnc2c(NCc3nnc4ccc(-c5cc(F)c(F)c(F)c5)nn34)ccnc2c1 CHEMBL565843 Ki 2.7 nM
Cc1c(OCC(O)CO)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4292983 IC50 2.7 nM
Cc1c(C(C)n2cnc3ncc(-c4cn[nH]c4)nc32)ccc2ncccc12 CHEMBL4549233 EC50 2.7 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385205 IC50 2.72 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccccc5)nc5ccccc45)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2392942 IC50 2.72 nM
CC(NC/N=C/c1ccc(C(N)=O)c(F)c1)c1ccc2ncccc2c1 CHEMBL4559359 EC50 2.74 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Br)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385206 IC50 2.76 nM
C[C@H](c1cc2cccnc2cc1F)n1cnc2ncc(-c3ccc(C(N)=O)c(F)c3)nc21 CHEMBL4519232 EC50 2.79 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1c[nH]cc(-c2ccc(F)cc2)c1=O CHEMBL454356 IC50 2.8 nM
CCCCC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc21 CHEMBL3263972 IC50 2.8 nM
Nc1noc2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL3394457 IC50 2.8 nM
COc1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582288 IC50 2.8 nM
FC(F)(c1ccc2ncccc2c1)c1nnc2ncc(-c3ccccc3)nn12 CHEMBL3800061 IC50 2.8 nM
C/C(=N\OCCO)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3648234 IC50 2.8 nM
C/C(=N\OCCO)c1ccc2ncc(C(C)c3c(F)cc4c(cnn4C)c3F)n2n1 CHEMBL3651393 IC50 2.8 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc6c(c5)CC(=O)N6)cn34)ccnc2c1 CHEMBL3668181 Ki 2.8 nM
Cc1c(OCCCN2CCOCC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4276790 IC50 2.8 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(CCO)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5170338 IC50 2.8 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5c(C)cccc5C)C4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3116244 IC50 2.83 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc5cccnc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4282738 IC50 2.86 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1 CHEMBL4799113 IC50 2.89 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccccc5Cl)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3594104 IC50 2.9 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc6c(c5)CCO6)nn34)ccnc2c1 CHEMBL3668158 Ki 2.9 nM
COC(=O)c1ccc(-c2cnc3ncn(C(C)c4cc5cccnc5cc4F)c3n2)cc1F CHEMBL4587352 EC50 2.9 nM
CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C)N1 CHEMBL4593677 IC50 2.9 nM
O=C1NCCCCn2cc(cn2)-c2cnc3ccc(cc3c2)CCn2nc(ccc2=O)-c2ccc1c(C(F)(F)F)c2 CHEMBL5181396 IC50 2.9 nM
COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cn3)c2cc1OC CHEMBL510112 Ki 3.0 nM
Nc1nccc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)c1C#CCO CHEMBL500157 IC50 3.0 nM
CNC(=O)c1ccc(-c2ccc3nnc(Cc4ccc(O)cc4)n3n2)cc1F CHEMBL494984 IC50 3.0 nM
COc1cnc2c(NCc3nnc4ccc(-c5cc(F)cc(F)c5)nn34)ccnc2c1 CHEMBL568138 IC50 3.0 nM
COc1cnc2c(NCc3nnc4ccc(-c5cc(C)ns5)nn34)ccnc2c1 CHEMBL566685 IC50 3.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c(-c4nc5ccccc5o4)c3)cn2)CC1 CHEMBL1171941 IC50 3.0 nM
COCCCN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1802913 IC50 3.0 nM
Cn1cc(-c2cnc3ccc4ccc(NS(N)(=O)=O)cc4c(=O)c3c2)cn1 CHEMBL1802906 IC50 3.0 nM
COCC(F)Cn1cc(-c2cnc3ccc4ccc(NS(=O)(=O)N(C)C)cc4c(=O)c3c2)cn1 CHEMBL1802836 IC50 3.0 nM
CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(CCF)c4)cc3c(=O)c2c1 CHEMBL1802834 IC50 3.0 nM
CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(CCCO)c4)cc3c(=O)c2c1 CHEMBL1802833 IC50 3.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5ccccc5)nn34)cccc12 CHEMBL1922405 IC50 3.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5cccc(F)c5)nn34)cccc12 CHEMBL1922416 IC50 3.0 nM
N#Cc1cccc(-c2ccc3nnc(Cc4cccc5c(=O)[nH]ccc45)n3n2)c1 CHEMBL1922418 IC50 3.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5cccc(O)c5)nn34)cccc12 CHEMBL1922419 IC50 3.0 nM
Cc1cc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2c(C)c1O CHEMBL2032277 IC50 3.0 nM
Cc1cc(-n2ccc3nnn(Cc4ccc5ncccc5c4)c3c2=O)sn1 CHEMBL2029561 IC50 3.0 nM
COc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c43)cc2c1 CHEMBL2029562 IC50 3.0 nM
C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cnn(C)c3)c(=O)c21 CHEMBL2029683 IC50 3.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5ccncc5)cc4c(=O)c3c2)cn1 CHEMBL2323774 IC50 3.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5cnsc5)cc4c(=O)c3c2)cn1 CHEMBL2323772 IC50 3.0 nM
Cc1nccc(CNS(=O)(=O)Cc2ccc3ccc4ncc(-c5cnn(C)c5)cc4c(=O)c3c2)n1 CHEMBL2323771 IC50 3.0 nM
COc1ccc(-c2ccc3nnc([C@@H](C)c4ccc5ncccc5c4)n3n2)cc1C CHEMBL2431824 Ki 3.0 nM
[2H]C([2H])(O)CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3221133 IC50 3.0 nM
C[C@@H](c1ccn2nccc2c1)n1nnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL3334569 IC50 3.0 nM
O=c1ccc(-c2cc(F)c(F)c(F)c2)nn1C[C@@H]1CN(c2ncc(-c3cnn(C4CCN(CCO)CC4)c3)cn2)CCO1 CHEMBL3335768 IC50 3.0 nM
COc1cnc2ccc(C(F)(F)c3nnc4c(F)cc(-c5cc(C)no5)cn34)cc2c1 CHEMBL3414913 IC50 3.0 nM
Cc1cc(-c2cc(F)c3nnc([C@@H](C)n4ccc5ncccc5c4=O)n3c2)on1 CHEMBL3786495 IC50 3.0 nM
COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(-c5cnn(C)c5)cn34)c(=O)c2c1 CHEMBL3786005 IC50 3.0 nM
CC(=O)N/N=C(\C)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL3674480 IC50 3.0 nM
C/C(=N\N1CCOC1=O)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL4114720 IC50 3.0 nM
C/C(=N\N(C)C(N)=O)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3674496 IC50 3.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(Cc3c(F)cc4c(cnn4C)c3F)n2n1 CHEMBL3674507 IC50 3.0 nM
C/C(=N\NC(N)=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3674527 IC50 3.0 nM
C/C(=N\NC(N)=O)c1cnc2nnn(C(C)c3cc4cccnc4cc3F)c2n1 CHEMBL3674542 IC50 3.0 nM
CC(N=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3648243 IC50 3.0 nM
C/C(=N\OCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3651395 IC50 3.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(NC6CC(C)(C)NC(C)(C)C6)cc5c4)n3c2)cn1 CHEMBL3703944 IC50 3.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCCC(N)C6)cc5c4)n3c2)cn1 CHEMBL3703947 IC50 3.0 nM
CN1CCCN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3703953 IC50 3.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCNCC6)cc5c4)n3c2)cn1 CHEMBL3703961 IC50 3.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(N6CCC(N7CCCCC7)CC6)cc5c4)n3c2)cn1 CHEMBL3703965 IC50 3.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(O)CC6)cc5c4)n3c2)cn1 CHEMBL3703984 IC50 3.0 nM
Fc1cc(-c2cn[nH]c2)cn2c(Sc3ccc4ncc(N5CCOCC5)cc4c3)nnc12 CHEMBL3703993 IC50 3.0 nM
CC1COCCN1c1cnc2ccc(Sc3nnc4ccc(-c5cnn(C)c5)cn34)cc2c1 CHEMBL3703994 IC50 3.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCOCC6)cc5c4)n3c2)cn1 CHEMBL3704001 IC50 3.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(N6CCOCC6)cc5c4)n3c2)cn1 CHEMBL3704002 IC50 3.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncccc5c4)n3c2)cn1 CHEMBL3704018 IC50 3.0 nM
Cn1cc(-c2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)cn1 CHEMBL3704019 IC50 3.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(C6=CCOCC6)cn5)CCO4)c3n2)cn1 CHEMBL3903772 IC50 3.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6cnn(CCO)c6)cn5)CCO4)c3n2)cn1 CHEMBL3905540 IC50 3.0 nM
CN1CCN(Cc2ccc(-c3cnc(N4CCO[C@H](Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2)CC1 CHEMBL3950590 IC50 3.0 nM
CN1CC=C(c2cnc(N3CCO[C@H](Cn4nnc5ncc(-c6cccc(C#N)c6)nc54)C3)nc2)CC1 CHEMBL3949460 IC50 3.0 nM
Cn1cc(-c2cnc3nnn(CC4CCCN(c5ncc(C6=CCNCC6)cn5)C4)c3n2)cn1 CHEMBL3925783 IC50 3.0 nM
CN1CC=C(c2cnc(N3CCCC(Cn4nnc5ncc(-c6cnn(C)c6)nc54)C3)nc2)CC1 CHEMBL3907132 IC50 3.0 nM
Cn1cc(-c2cnc3nnn(CC4CCCN(c5ncc(C6=CCN(CCO)CC6)cn5)C4)c3n2)cn1 CHEMBL3913877 IC50 3.0 nM
N#Cc1cc(-c2cnc3nnn(CC4CN(c5ncc(C6=CCN(CCO)CC6)cn5)CCO4)c3n2)ccc1F CHEMBL3936536 IC50 3.0 nM
Cc1n[nH]c2cc(F)c(C3C(C#N)=C(C(F)F)NC(C(F)F)=C3C#N)cc12 CHEMBL3972144 IC50 3.0 nM
CCC(F)(F)C1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C)N1 CHEMBL3947404 IC50 3.0 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(Oc5cccc(F)c5)nn34)cc2s1 CHEMBL4472923 IC50 3.0 nM
CCOc1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 CHEMBL4462907 IC50 3.0 nM
CCN(CC)CCNC(=O)Nc1nc2ccc(Sc3nnc4ccc(-c5ccc(F)cc5)nn34)cc2s1 CHEMBL4459929 IC50 3.0 nM
O=C(Nc1nc2ccc(Sc3nnc4ccc(-c5ccc(F)cc5)nn34)cc2s1)C1CC1 CHEMBL4457387 IC50 3.0 nM
C[C@@H](Oc1cncc(-c2cnn(C3CCN(CC(N)=O)CC3)c2)c1)c1c(Cl)ccc(F)c1Cl CHEMBL4645582 IC50 3.0 nM
Cc1nn(C)cc1-c1nn2c([C@H](C)c3ccc4ncccc4c3)nnc2s1 CHEMBL4750387 IC50 3.0 nM
Cc1nn(C)cc1-c1nn2c([C@@H](C)c3ccc4ncccc4c3)nnc2s1 CHEMBL4783289 IC50 3.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(F)c5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385203 IC50 3.02 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)c(F)c5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343369 IC50 3.02 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5c(C)cccc5C)C4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3116223 IC50 3.03 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3918992 IC50 3.03 nM
COc1cc2c(Oc3ccc(CC(=O)N/N=C(/C)c4ccc(C(F)(F)F)cc4)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3339368 IC50 3.05 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5Cl)nn4)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3823902 IC50 3.08 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3116434 IC50 3.09 nM
Cn1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(=O)c(-c2ccc(F)cc2)c1 CHEMBL454357 IC50 3.1 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCCO4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4865357 IC50 3.1 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)c(F)c5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3343385 IC50 3.12 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(C(F)(F)F)c5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385204 IC50 3.13 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5cccc(Cl)c5)nc5ccccc45)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2392967 IC50 3.13 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccccc4F)C(C)(C)C)cc3F)c2cc1OC CHEMBL4752320 IC50 3.13 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)c(Cl)c5)C4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3116234 IC50 3.15 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3116232 IC50 3.15 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)c(Cl)c5)C4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3116239 IC50 3.15 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2)cc1 CHEMBL1977148 pKi 3.162 nM
CC(C)Oc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL461582 IC50 3.2 nM
Cn1cc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)cc2)c(=O)n1-c1ccccc1 CHEMBL3093587 IC50 3.2 nM
OCCn1cc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cn1 CHEMBL3582280 IC50 3.2 nM
c1ccc(Cn2cc(-c3cnc4nnc(Cc5ccc6ncccc6c5)n4n3)cn2)cc1 CHEMBL3798660 IC50 3.2 nM
COc1ccc2c(OCc3nnc4ccc(-c5cc(C)no5)cn34)ccnc2c1 CHEMBL3668184 Ki 3.2 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2103868 IC50 3.2 nM
Cc1c(C(C)n2cnc3ncc(-c4cnn(C)c4)nc32)ccc2ncccc12 CHEMBL4531351 EC50 3.2 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccccc5Cl)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4065200 IC50 3.23 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)c(F)c5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3343393 IC50 3.25 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5c(C)cccc5C)C4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3116231 IC50 3.26 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(Cl)c5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3781674 IC50 3.26 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccccc5)C4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3116229 IC50 3.29 nM
N#Cc1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582287 IC50 3.3 nM
CC(NC/N=C/c1cnc2[nH]ccc2c1)c1ccc2ncccc2c1 CHEMBL4526936 EC50 3.3 nM
O=C1NCCCCCn2cc(cn2)-c2cnc3ccc(cc3c2)CCn2nc(ccc2=O)-c2ccc1c(C(F)(F)F)c2 CHEMBL5190062 IC50 3.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5)c4C)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3343380 IC50 3.34 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccccc5)C4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3116439 IC50 3.36 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cn(C2CC2)cc(-c2ccc(F)cc2)c1=O CHEMBL455386 IC50 3.4 nM
COc1cc2c(Oc3ccc(-c4cnc(Nc5ccc(F)cc5)n(C)c4=O)nc3)ccnc2cc1OCCCN1CCOCC1 CHEMBL447602 Ki 3.4 nM
Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1CO CHEMBL517293 IC50 3.4 nM
CC(C)c1c(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)ccnc1N CHEMBL462623 IC50 3.4 nM
O=[N+]([O-])c1cccc(CNc2cc(C(F)(F)F)cc3ncc(N4CCCCC4)cc23)c1 CHEMBL1766538 IC50 3.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1C CHEMBL2031895 Ki 3.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2385191 IC50 3.4 nM
O=C(NCCCN1CCCC1)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582299 IC50 3.4 nM
Cc1ccc2c(c1)oc(=O)n2CCOc1ccnc2cc(-c3cnn(C)c3)ccc12 CHEMBL3787612 IC50 3.4 nM
CC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3cnc4ccccc4c3)nc21 CHEMBL4566100 EC50 3.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccccc5)nc5ccc(F)cc45)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2392948 IC50 3.45 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5)c4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3343388 IC50 3.45 nM
COCCOc1ccc2c(OCCn3c(=O)oc4cc(C)ccc43)ccnc2c1 CHEMBL3786136 IC50 3.5 nM
C/C(=N\OCCO)c1ccc2nnc([C@@H](C)c3c(F)cc4ncccc4c3F)n2n1 CHEMBL3651426 IC50 3.5 nM
CNC(=O)c1ccc(-c2cnc3nnn(C(C)c4ccc5ncc(-c6ccc(F)cc6)cc5c4)c3n2)cc1F CHEMBL4099662 IC50 3.5 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OCCO CHEMBL4780196 IC50 3.5 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)c(F)c5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL2385197 IC50 3.55 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL4098250 IC50 3.57 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3116224 IC50 3.58 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cc2cccnc2n(-c2ccccc2)c1=O CHEMBL4278233 IC50 3.59 nM
CNC(=O)c1ccc(-c2ccc(=O)n(Cc3cccc(Nc4ncc(-c5cnn(C)c5)cn4)c3)n2)cc1F CHEMBL3758464 IC50 3.6 nM
OCCO/N=C/c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3648259 IC50 3.6 nM
CC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3cn[nH]c3)nc21 CHEMBL4538345 EC50 3.6 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL2385174 IC50 3.64 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)cc5)C4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3116237 IC50 3.64 nM
CC(NC/N=C/c1ccncc1)c1ccc2ncccc2c1 CHEMBL4586780 EC50 3.67 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343368 IC50 3.68 nM
CCN1CCN(CCCOc2cc3nccc(Oc4c(F)cc(NC(=O)NN5C(=O)CS[C@H]5c5ccc(F)cc5F)cc4F)c3cc2OC)CC1 CHEMBL5395266 IC50 3.69 nM
Cc1ccc(NC(=O)C2(C(=O)Nc3ccc(-c4cccc5[nH]nc(N)c45)c(F)c3)CC2)cc1 CHEMBL3394470 IC50 3.7 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(Nc5ccc(C(=O)Nc6ccccc6N)nc5)ccc34)n2)cn1 CHEMBL4204322 IC50 3.7 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5c(C)cccc5C)C4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3116445 IC50 3.72 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cn(CCO)cc(-c2ccc(F)cc2)c1=O CHEMBL508633 IC50 3.8 nM
NCC#Cc1c(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)ccnc1N CHEMBL460502 IC50 3.8 nM
CS(=O)(=O)Cc1cccc(Nc2cc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccn2)c1 CHEMBL3287603 IC50 3.8 nM
Cc1ccc2c(c1)oc(=O)n2CCOc1ccnc2cc(OCCN3CCOCC3)ccc12 CHEMBL3786610 IC50 3.8 nM
Cc1ccc2c(c1)oc(=O)n2CCOc1ccnc2cc(OCCCN3CCOCC3)ccc12 CHEMBL3787354 IC50 3.8 nM
C/C(=N\O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1 CHEMBL3651430 IC50 3.8 nM
C/C(=N\OCCF)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3651396 IC50 3.8 nM
CC(c1c(F)cc2ncc(-c3ccc(F)cc3)cc2c1F)n1nnc2ncc(-c3cnn(C)c3)nc21 CHEMBL4102466 IC50 3.8 nM
Cc1c(OCCCS(C)(=O)=O)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4287439 IC50 3.8 nM
CC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3ccncc3)nc21 CHEMBL4553657 EC50 3.8 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(F)c1 CHEMBL4790582 IC50 3.83 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccccc5)C4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3116242 IC50 3.84 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5OC(F)(F)F)c(=O)n4C4CC4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3911896 IC50 3.85 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CCN)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2032024 Ki 3.9 nM
COc1cc2c(Oc3ccc(NC(=O)N/N=C/c4ccccc4F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2419668 IC50 3.9 nM
CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc5nonc45)c3c2)CC1 CHEMBL3221125 IC50 3.9 nM
CNC(=O)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582294 IC50 3.9 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5OC)cn4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3900221 IC50 3.9 nM
C/C(=N\OCCNC(N)=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3648258 IC50 3.9 nM
Cc1ccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)cc1 CHEMBL4473908 IC50 3.9 nM
COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL4753082 IC50 3.9 nM
CNC(=O)c1ccc(/C=N/CNC(C)c2ccc3ncccc3c2)cc1F CHEMBL4560881 EC50 3.95 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3309404 IC50 3.98 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3343376 IC50 3.98 nM
COc1cc2c(Oc3ccc(CC(=O)N/N=C/c4ccc(OC(F)(F)F)cc4)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3339359 IC50 3.98 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 3.981 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 3.981 nM
CN(C)CC#Cc1c(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)ccnc1N CHEMBL525049 IC50 4.0 nM
O=C(Cc1ccc(F)cc1)NC(=O)Nc1ccc(Oc2ccnc3[nH]cc(CO)c23)c(F)c1 CHEMBL499886 IC50 4.0 nM
Oc1ccc(Cc2nnc3ccc(-c4ccsc4)nn23)cc1 CHEMBL497117 IC50 4.0 nM
COc1ccc2c(OCc3nnc4ccc(-c5cc(F)c(F)c(F)c5)nn34)ccnc2c1 CHEMBL494979 IC50 4.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccccc6)CC5)cc4F)c3s2)c1 CHEMBL565807 IC50 4.0 nM
CCN(CC)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1802908 IC50 4.0 nM
CN(C)CCCn1cc(-c2cnc3ccc4ccc(NS(=O)(=O)N(C)C)cc4c(=O)c3c2)cn1 CHEMBL1802832 IC50 4.0 nM
CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1802829 IC50 4.0 nM
Cn1cc(-c2cnc3ccc4ccc(NS(C)(=O)=O)cc4c(=O)c3c2)cn1 CHEMBL1802602 IC50 4.0 nM
CCN(CC)CCOc1ccc(Nc2nccc(-c3[nH]c(-c4c(Cl)cc(CO)cc4Cl)nc3-c3cccc(Cl)c3)n2)cc1 CHEMBL1822790 IC50 4.0 nM
Oc1ccc(Cc2nnc3ncc(-c4cccs4)nn23)cc1 CHEMBL1822974 IC50 4.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5ccsc5)nn34)cccc12 CHEMBL1922410 IC50 4.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5ccccc5Cl)nn34)cccc12 CHEMBL1922414 IC50 4.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5cccc([N+](=O)[O-])c5)nn34)cccc12 CHEMBL1922417 IC50 4.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(O)c(-c3cccnc3)c2o1 CHEMBL2032281 IC50 4.0 nM
CCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL2170954 Ki 4.0 nM
N#Cc1ccc(-c2cnc3nnc(Cc4c[nH]c5ncccc45)n3n2)cc1 CHEMBL2170968 Ki 4.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cccc(C#N)c3)nn12 CHEMBL2431826 IC50 4.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccc4c(c3)OCCO4)nn12 CHEMBL2431829 Ki 4.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccc(F)c(F)c3)nn12 CHEMBL2431822 Ki 4.0 nM
COc1ccc(-c2ccc3nnc([C@@H](C)c4ccc5ncccc5c4)n3n2)cc1F CHEMBL2431823 Ki 4.0 nM
FC(F)(F)Cn1cc(-c2cnc3nnn(Cc4ccc5nccn5c4)c3n2)cn1 CHEMBL3334540 IC50 4.0 nM
N#Cc1cccc(-c2ccc(=O)n(C[C@@H]3CN(c4ncc(-c5cnn(CC6CCN(CCO)CC6)c5)cn4)CCO3)n2)c1 CHEMBL3335778 IC50 4.0 nM
Cn1cc(-c2cnc(N3CCO[C@H](Cn4nc(-c5cccc(C#N)c5)ccc4=O)C3)nc2)cn1 CHEMBL3335773 IC50 4.0 nM
COc1cnc2ccc([C@@](C)(F)c3nnc4c(F)cc(-c5cc(C)ns5)cn34)cc2c1 CHEMBL3414917 IC50 4.0 nM
Fc1cc(-c2cscn2)cn2c(C(F)(F)c3ccc4ncccc4c3)nnc12 CHEMBL3414738 IC50 4.0 nM
C/C(=N\n1cc(O)[nH]c1=O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1 CHEMBL3897857 IC50 4.0 nM
C/C(=N\N(C)C(N)=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3674517 IC50 4.0 nM
C/C(=N\NC(N)=O)c1ccc2nnc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL3674520 IC50 4.0 nM
C/C(=N\N1CCOC1=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL4114711 IC50 4.0 nM
CC/C(=N\NC(N)=O)c1ccc2ncc(Cc3cc4cnn(C)c4cc3F)n2n1 CHEMBL3674555 IC50 4.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NCC6CCOC6)cc5c4)n3c2)cn1 CHEMBL3703948 IC50 4.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CC7(COC7)C6)cc5c4)n3c2)cn1 CHEMBL3703949 IC50 4.0 nM
CN1CCC(Nc2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3703952 IC50 4.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(NC6CCOCC6)cc5c4)n3c2)cn1 CHEMBL3703960 IC50 4.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCCN(CCO)CC6)cc5c4)n3c2)cn1 CHEMBL3703963 IC50 4.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(N7CCCC7)CC6)cc5c4)n3c2)cn1 CHEMBL3703967 IC50 4.0 nM
CC1CN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CCO1 CHEMBL3703969 IC50 4.0 nM
C[C@@H]1CN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CCO1 CHEMBL3703971 IC50 4.0 nM
CC1CN(c2cnc3ccc(Sc4nnc5c(F)cc(-c6cnn(C)c6)cn45)cc3c2)CCO1 CHEMBL3703972 IC50 4.0 nM
C[C@@H]1CN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)C[C@H](C)N1 CHEMBL3703978 IC50 4.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(N6CCC(O)CC6)cc5c4)n3c2)cn1 CHEMBL3703985 IC50 4.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NC6CCOC6)cc5c4)n3c2)cn1 CHEMBL3703986 IC50 4.0 nM
CC1COCCN1c1cnc2ccc(Sc3nnc4c(F)cc(-c5cnn(C)c5)cn34)cc2c1 CHEMBL3703995 IC50 4.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(F)(F)CC6)cc5c4)n3c2)cn1 CHEMBL3703996 IC50 4.0 nM
CN1CCN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3704005 IC50 4.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6cnn(C7CCN(CCO)CC7)c6)cn5)CCO4)c3n2)cn1 CHEMBL3942646 IC50 4.0 nM
CN1CC=C(c2cnc(N3CCO[C@H](Cn4nnc5ncc(-c6cnn(C)c6)nc54)C3)nc2)CC1 CHEMBL3902731 IC50 4.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(C6=CCN(CCO)CC6)cn5)CCO4)c3n2)cn1 CHEMBL3970370 IC50 4.0 nM
N#Cc1cccc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(C6=CCNCC6)cn5)CCO4)c3n2)c1 CHEMBL3892437 IC50 4.0 nM
Cn1cc(-c2cnc(N3CCO[C@H](Cn4nnc5ncc(-c6cccc(C#N)c6)nc54)C3)nc2)cn1 CHEMBL3919877 IC50 4.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6ccc(CN7CCOCC7)c(F)c6)cn5)CCO4)c3n2)cn1 CHEMBL3950728 IC50 4.0 nM
O=C(CC1CC1)Nc1nc2ccc(Sc3nnc4ccc(-c5ccc(F)cc5)nn34)cc2s1 CHEMBL4576381 IC50 4.0 nM
CC(C)N1CCC(n2cc(-c3cncc(O[C@H](C)c4c(Cl)ccc(F)c4Cl)c3)cn2)CC1 CHEMBL4649193 IC50 4.0 nM
Cn1cc(Nc2nn3c(C(F)(F)c4ccc5ncccc5c4)nnc3s2)cn1 CHEMBL4778083 IC50 4.0 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)cc1 CHEMBL5179451 IC50 4.0 nM
COC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5190727 IC50 4.0 nM
CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(-c4cn(C)cn4)sc23)c(F)c1 CHEMBL5404435 IC50 4.0 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCCCC4)c(OC)cc23)c(F)c1 CHEMBL4778488 IC50 4.02 nM
CCn1cc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cn1 CHEMBL3799924 IC50 4.1 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)c(C(F)(F)F)c5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2385194 IC50 4.12 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5Cl)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3343384 IC50 4.12 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccccc5Cl)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3594103 IC50 4.16 nM
O=C(NC1CCOCC1)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582304 IC50 4.2 nM
Brc1ccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cc1 CHEMBL3798130 IC50 4.2 nM
COc1ccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)cc1C CHEMBL4589258 IC50 4.2 nM
Cc1c(C(C)n2cnc3ncc(-c4cnn(CCO)c4)nc32)ccc2ncccc12 CHEMBL4587451 EC50 4.2 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C6CCNCC6)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5177753 IC50 4.2 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343365 IC50 4.24 nM
Fc1cc(-c2ccsc2)cn2c(Cc3ccc4ncccc4c3)cnc12 CHEMBL3582282 IC50 4.3 nM
CN1CCC(n2cc(-c3cnc(Nc4cccc(Cn5nc(-c6cnn(C)c6)ccc5=O)c4)nc3)cn2)CC1 CHEMBL3759495 IC50 4.3 nM
Cn1cc(-c2cnc(Nc3cccc(Cn4nc(-c5ccc(Cl)c(C(F)(F)F)c5)ccc4=O)c3)nc2)cn1 CHEMBL3758452 IC50 4.3 nM
CC(c1c(F)cc2ncc(-c3ccc(F)cc3)cc2c1F)n1nnc2ncc(-c3ccncc3)nc21 CHEMBL4065641 IC50 4.3 nM
COc1cc2c(Oc3ccc(/C=N/NC(=O)Nc4ccccc4F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4576664 IC50 4.3 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccccc5)C4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3116446 IC50 4.31 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(F)c5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3309403 IC50 4.31 nM
CCN1CCN(CCCOc2cc3nccc(Oc4c(F)cc(NC(=O)NN5C(=O)CSC5c5ccc(F)cc5F)cc4F)c3cc2OC)CC1 CHEMBL5409449 IC50 4.32 nM
CCn1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCC(C)CC5)c(OC)cc34)c(F)c2)nn(-c2ccccc2OC(F)(F)F)c1=O CHEMBL3911762 IC50 4.33 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3343381 IC50 4.35 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(Cl)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3593692 IC50 4.36 nM
O=C(O)CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL1766546 IC50 4.4 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC5CNC(=O)O5)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2032032 Ki 4.4 nM
COc1cc2c(Oc3ccc(NC(=S)N/N=C/c4ccccc4[N+](=O)[O-])cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2419648 IC50 4.4 nM
COc1cc2c(Oc3ccc(NC(=O)N/N=C/c4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2419667 IC50 4.4 nM
Cc1c(C(C)n2cnc3ncc(-c4ccncc4)nc32)ccc2ncccc12 CHEMBL4521693 EC50 4.4 nM
Nc1ncnc2[nH]cc(-c3ccc(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3)c12 CHEMBL4860162 IC50 4.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccccc5)ccn4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL2435998 IC50 4.48 nM
Nc1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)ccn1 CHEMBL516790 IC50 4.5 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cc(C(F)(F)F)ccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL2385199 IC50 4.5 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(Cl)cc5)CC4)cc3F)c12 CHEMBL3394471 IC50 4.5 nM
CC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL4579449 EC50 4.5 nM
CC(C)n1cc(C(=O)Nc2cc(F)c(-c3c[nH]c4ncnc(N)c34)cc2F)c(=O)c(-c2ccc(F)cc2)c1 CHEMBL4871361 IC50 4.5 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccccc5F)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4092858 IC50 4.52 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c(=O)n4C4CC4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3938747 IC50 4.55 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccccc5)C4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3116221 IC50 4.57 nM
COCCOc1ccc2c(OCCn3nc(-n4ccc5ccc(F)cc54)ccc3=O)ccnc2c1 CHEMBL3414602 IC50 4.6 nM
CC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3ccccc3)nc21 CHEMBL4590141 EC50 4.6 nM
COc1cc2c(Oc3ccc(NC(=O)NS(=O)(=O)Cc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4535560 IC50 4.64 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3343373 IC50 4.69 nM
O=C(NCc1cc(F)cc(F)c1)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582303 IC50 4.7 nM
COc1ccc2c(OCc3nnc4ccc(-c5cnc(C)s5)nn34)ccnc2c1 CHEMBL3668173 Ki 4.7 nM
Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1 CHEMBL3545307 IC50 4.7 nM
CCC(=O)Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1 CHEMBL4529670 IC50 4.7 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4cc(F)cc(F)c4)c3=O)cc2F)c1Cl CHEMBL4528003 IC50 4.7 nM
Cc1cccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)c1 CHEMBL4455924 IC50 4.7 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4cccc(F)c4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4799621 IC50 4.72 nM
COc1ccc2c(OCc3nnc4ccc(-c5cc(F)c(F)c(F)c5)cn34)ccnc2c1 CHEMBL2032039 Ki 4.8 nM
Fc1ccc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1 CHEMBL2169896 Ki 4.8 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5OC(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL2385177 IC50 4.8 nM
C[C@@H](Oc1cc(-c2cnn(C3CCC4(CC3)CNC4)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4109336 IC50 4.8 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCCCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4849955 IC50 4.8 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5172104 IC50 4.8 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)c(Cl)c5)C4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3116436 IC50 4.82 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3343392 IC50 4.89 nM
COc1cc2c(Oc3ccc(-c4cnc(Nc5ccc(F)cc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL453737 Ki 4.9 nM
COc1cc2c(Oc3ccc(-c4cnc(Nc5ccccc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL2385184 IC50 4.9 nM
COc1cnc2c(NCc3nnc4ccc(-c5ccc(=O)n(C)c5)nn34)ccnc2c1 CHEMBL3668167 Ki 4.9 nM
COC(=O)c1ccc(-c2cnc3ncn(C(C)c4c(F)cc5ncccc5c4F)c3n2)cc1F CHEMBL4554813 EC50 4.9 nM
Cc1c(C(C)n2cnc3ncc(-c4cnc5ccccc5c4)nc32)ccc2ncccc12 CHEMBL4540942 EC50 4.9 nM
Cn1cc(-c2cnc3ccc(CCn4nc(-c5cccc(Cl)c5)ccc4=O)cc3c2)cn1 CHEMBL5203866 IC50 4.9 nM
COc1cc2c(Oc3ccc(CC(=O)N/N=C/c4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3339356 IC50 4.95 nM
NCC#Cc1c(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)ccnc1N CHEMBL526929 IC50 5.0 nM
Nc1nccc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)c1C#Cc1ccccn1 CHEMBL500422 IC50 5.0 nM
COC(=O)c1c[nH]c2nccc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)c12 CHEMBL499885 IC50 5.0 nM
Cn1cc(-c2cnc3ccc4ccc(NS(=O)(=O)N5CC(F)C5)cc4c(=O)c3c2)cn1 CHEMBL1802912 IC50 5.0 nM
CNc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 CHEMBL1802605 IC50 5.0 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1\C(=O)Nc2cc(C(=O)NCCN3CCOCC3)cc(Br)c21 CHEMBL1822365 IC50 5.0 nM
CN(C)CCCNC(=O)c1cc(Br)c2c(c1)NC(=O)/C2=N\NC(=O)Cc1ccc2c(c1)CCO2 CHEMBL1822367 IC50 5.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5cn[nH]c5)nn34)cccc12 CHEMBL1921807 IC50 5.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5cccnc5)nn34)cccc12 CHEMBL1922411 IC50 5.0 nM
COc1cccc(-c2ccc3nnc(Cc4cccc5c(=O)[nH]ccc45)n3n2)c1 CHEMBL1922420 IC50 5.0 nM
Fc1ccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cc1 CHEMBL2170967 IC50 5.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5ccccc5Cl)cc4c(=O)c3c2)cn1 CHEMBL2323769 IC50 5.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccccc3C#N)nn12 CHEMBL2431828 IC50 5.0 nM
Cc1cccc(-c2ccc3nnc([C@@H](C)c4ccc5ncccc5c4)n3n2)c1 CHEMBL2431825 Ki 5.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3263959 IC50 5.0 nM
COc1cc(=O)n(-c2ccc(Oc3ccnc(N)c3I)c(F)c2)cc1C(=O)NCc1ccc(F)cc1 CHEMBL3309969 IC50 5.0 nM
OCCn1cc(-c2cnc3nnn(Cc4c[nH]c5ncccc45)c3n2)cn1 CHEMBL3334556 IC50 5.0 nM
OCCn1cc(-c2cnc3nnn(Cc4ccn5nccc5c4)c3n2)cn1 CHEMBL3334551 IC50 5.0 nM
N#Cc1cccc(-c2ccc(=O)n(C[C@@H]3CN(c4ncc(-c5cnn(C6CCN(C7CCOCC7)CC6)c5)cn4)CCO3)n2)c1 CHEMBL3335787 IC50 5.0 nM
N#Cc1cccc(-c2ccc(=O)n(C[C@@H]3CN(c4ncc(-c5cnn(C6CCNCC6)c5)cn4)CCO3)n2)c1 CHEMBL3335760 IC50 5.0 nM
COc1cnc2ccc([C@@](C)(F)c3nnc4c(F)cc(-c5cnn(C)c5)cn34)cc2c1 CHEMBL3414919 IC50 5.0 nM
Cc1cc(-c2cc(F)c3nnc([C@](C)(F)c4ccc5ncccc5c4)n3c2)sn1 CHEMBL3414577 IC50 5.0 nM
CC(N=N)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3674534 IC50 5.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(Cc3cc4cnn(C)c4cc3F)n2n1 CHEMBL3674544 IC50 5.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(N)C6)cc5c4)n3c2)cn1 CHEMBL3703939 IC50 5.0 nM
C[C@H]1CN(c2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CCO1 CHEMBL3703970 IC50 5.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC7(CCOCC7)C6)cc5c4)n3c2)cn1 CHEMBL3703982 IC50 5.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(N6CCC7(CCOCC7)C6)cc5c4)n3c2)cn1 CHEMBL3703983 IC50 5.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NC6CCOCC6)cc5c4)n3c2)cn1 CHEMBL3704000 IC50 5.0 nM
C/C(=N\O)c1ccc2nnc(Sc3ccc4ncc(N5CCOCC5)cc4c3)n2c1 CHEMBL3704008 IC50 5.0 nM
Cn1cc(-c2cnc3ccc(Sc4nnc5ccc(-c6cnn(CCO)c6)cn45)cc3c2)cn1 CHEMBL3704020 IC50 5.0 nM
COc1cnc2c(NCc3nnc4ccc(-c5ccc6c(c5)CN(C)C6=O)nn34)ccnc2c1 CHEMBL3668130 Ki 5.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6ccc(CN7CCOCC7)cc6)cn5)CCO4)c3n2)cn1 CHEMBL3980547 IC50 5.0 nM
Cn1cc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(C6CCN(CCO)CC6)cn5)CCO4)c3n2)cn1 CHEMBL3974683 IC50 5.0 nM
N#Cc1cccc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(C6CCN(CCO)CC6)cn5)CCO4)c3n2)c1 CHEMBL3899155 IC50 5.0 nM
N#Cc1cccc(-c2cnc3nnn(C[C@@H]4CN(c5ncc(-c6cnn(C7CCNCC7)c6)cn5)CCO4)c3n2)c1 CHEMBL3944271 IC50 5.0 nM
CCCCOc1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 CHEMBL4472716 IC50 5.0 nM
COCCNC(=O)Nc1nc2cc(OS(=O)(=O)c3c(F)cccc3F)ccc2[nH]1 CHEMBL4448572 IC50 5.0 nM
C[C@@H](Oc1cncc(-c2cnn(C3CCN(CC4CC4)CC3)c2)c1)c1c(Cl)ccc(F)c1Cl CHEMBL4646769 IC50 5.0 nM
O=c1c(-c2ccc(F)cc2)c[nH]c2ccnc(Nc3ccc(Oc4ccnc5cc(O)ccc45)c(F)c3)c12 CHEMBL4793318 IC50 5.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2sc(Nc3cnn(C)c3)nn12 CHEMBL4787386 IC50 5.0 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(CCN6CCOCC6)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5170241 IC50 5.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3290910 IC50 5.02 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5Cl)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3343396 IC50 5.02 nM
Cc1cc(=O)n(-c2ccccc2F)nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL4093275 IC50 5.02 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(C(F)(F)F)c5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2385190 IC50 5.05 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Br)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2385189 IC50 5.08 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3343398 IC50 5.09 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1Br CHEMBL2031894 Ki 5.1 nM
NCC(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3220877 IC50 5.1 nM
O=C(N1CCOCC1)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 CHEMBL3221109 IC50 5.1 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)c(F)c3)c12 CHEMBL3394476 IC50 5.1 nM
Cc1ccc2c(c1)oc(=O)n2CCOc1ccnc2cc(OCCCN3CCN(C)CC3)ccc12 CHEMBL3785650 IC50 5.1 nM
C/C(=N\O[C@H]1CCN(C(N)=O)C1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3648240 IC50 5.1 nM
Cn1cc(-c2ccc(=O)n(CCOc3ccnc4cc(OCc5ccc(CCC(=O)Nc6ccccc6N)cc5)ccc34)n2)cn1 CHEMBL4210834 IC50 5.1 nM
CCCn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4864971 IC50 5.1 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3343389 IC50 5.12 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1 CHEMBL4790980 IC50 5.12 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)c(Cl)c5)C4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3116226 IC50 5.14 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(F)c(Cl)c5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3593888 IC50 5.16 nM
CC(NC/N=C/c1ccccc1)c1ccc2ncccc2c1 CHEMBL4532610 EC50 5.17 nM
Cc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c(F)c1 CHEMBL3093584 IC50 5.2 nM
C/C=C1/CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc21 CHEMBL3263976 IC50 5.2 nM
Nc1noc2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c12 CHEMBL3394450 IC50 5.2 nM
COCCCOc1cnc(-c2cccc(Cn3nc(-n4ccc5ccc(F)cc54)ccc3=O)c2)nc1 CHEMBL3417487 IC50 5.2 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc6c(c5)OCCN6C)nn34)ccnc2c1 CHEMBL3668157 Ki 5.2 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C(F)(F)F)c4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3343395 IC50 5.21 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385186 IC50 5.23 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1nnn(-c2ccccc2F)c1C(F)(F)F CHEMBL3774498 IC50 5.24 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5cccc(Br)c5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3343394 IC50 5.29 nM
COc1cc2c(Oc3ccc(NC(=S)N/N=C/c4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2419647 IC50 5.3 nM
CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnc4nnc(Cc5ccc6ncccc6c5)n4n3)cn2)CC1 CHEMBL3798590 IC50 5.3 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(C)(C)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC CHEMBL4215501 IC50 5.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(Cl)c5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3780761 IC50 5.32 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1 CHEMBL4790688 IC50 5.35 nM
C/C(=N\O[C@H]1CCNC1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3648238 IC50 5.4 nM
FC(F)(c1ccc2ncccc2c1)c1nnc2ccc(-c3ccccc3)nn12 CHEMBL3668154 Ki 5.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5)ccc4=O)cc3)ccnc2cc1OCCCCCCC(=O)NO CHEMBL4758378 IC50 5.4 nM
Cn1cc(-c2cnc3ccc(CCn4nc(-c5cccc(C(F)(F)F)c5)ccc4=O)cc3c2)cn1 CHEMBL5202957 IC50 5.4 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C6CCOCC6)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5191797 IC50 5.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(F)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3593690 IC50 5.41 nM
C/C(=N\OCCO)c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1 CHEMBL3648225 IC50 5.5 nM
Cc1cc2ccnc(Nc3ccc(Oc4ccnc(N)c4I)c(F)c3)c2c(=O)n1-c1ccccc1 CHEMBL4454810 IC50 5.5 nM
CC(C)(O)CN1CCC(COc2cnc(-c3cccc(Cn4c(=O)ccn5c6cc(C#N)ccc6nc45)c3)nc2)CC1 CHEMBL5419352 IC50 5.51 nM
CCN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc(C#N)c4)c3c2)CC1 CHEMBL1766533 IC50 5.6 nM
N#Cc1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cn1 CHEMBL3582283 IC50 5.6 nM
Cn1cc(-c2cnc(Nc3cccc(Cn4nc(-c5cccc(C#N)c5)ccc4=O)c3)nc2)cn1 CHEMBL3759100 IC50 5.6 nM
COc1ccc2c(OCCn3c(=O)oc4cc(-c5cnn(C)c5)ccc43)ccnc2c1 CHEMBL3787278 IC50 5.6 nM
COc1cc2c(Oc3ccc(NC(=O)/C=C/S(=O)(=O)c4ccccc4OC)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3890678 IC50 5.6 nM
Cc1cc(=O)n(-c2cccc(F)c2)nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL4087981 IC50 5.61 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3290918 IC50 5.63 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(Cl)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3593691 IC50 5.64 nM
COc1cccc(-c2ccc(=O)n(Cc3cccc(-c4ncc(OCCCN(C)C)cn4)c3)n2)c1 CHEMBL3402759 IC50 5.7 nM
COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2cc1OCCO CHEMBL4745046 IC50 5.7 nM
O=c1c(-c2ccccc2)c[nH]c2ccnc(Nc3ccc(Oc4ccnc5cc(OCCCN6CCOCC6)ccc45)c(F)c3)c12 CHEMBL4791178 IC50 5.7 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(F)c(F)c5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3593886 IC50 5.8 nM
Cn1cc(-c2cnc3ccc(CCn4nc(-c5ccc(C(=O)O)c(C(F)(F)F)c5)ccc4=O)cc3c2)cn1 CHEMBL5187748 IC50 5.8 nM
COc1cc2c(Oc3ccc(NC(=O)NS(=O)(=O)Cc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4575176 IC50 5.81 nM
COc1cc2c(Oc3ccc(CC(=O)N/N=C/c4ccc(C(F)(F)F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3339354 IC50 5.86 nM
CN1CCN(Cc2c(Oc3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)ccnc2N)CC1 CHEMBL515858 IC50 5.9 nM
Cc1ccc2c(c1)oc(=O)n2CCOc1ccnc2cc(OCCCN3CCCC3)ccc12 CHEMBL3786574 IC50 5.9 nM
COC(=O)c1ccc(-c2cnc3ncn(C(C)c4ccc5ncccc5c4C)c3n2)cc1F CHEMBL4529638 EC50 5.9 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2385193 IC50 5.92 nM
CNC(=O)c1ccc(-c2ccc3nnc(Cc4ccc(O)cc4)n3n2)cc1 CHEMBL494983 IC50 6.0 nM
Oc1ccc(Cc2nnc3ncc(-c4ccccc4)nn23)cc1 CHEMBL498769 IC50 6.0 nM
Cc1ccccc1NC(=O)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL1099174 IC50 6.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CCCC(=O)N3C)ncc1Cl CHEMBL1644799 IC50 6.0 nM
O=C(Cc1ccc2c(c1)CCO2)N/N=C1/C(=O)Nc2cc(C(=O)NCCCN3CCC[C@H]3CO)cc(Br)c21 CHEMBL1821773 IC50 6.0 nM
CNC(=O)c1ccc(-c2ccc3nnc(COc4ccnc5cc(OC)ccc45)n3n2)cc1 CHEMBL1823125 IC50 6.0 nM
O=C(O)Cn1cc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1 CHEMBL2170819 Ki 6.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5ccc(F)cc5F)cc4c(=O)c3c2)cn1 CHEMBL2324128 IC50 6.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12 CHEMBL2431819 IC50 6.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C(C)CN(C)CC3)ncc1Cl CHEMBL3263971 IC50 6.0 nM
Cn1cc(-c2cnc3nnn(Cc4cc5[nH]ncc5s4)c3n2)cn1 CHEMBL3334541 IC50 6.0 nM
Cn1cc(-c2cnc3nnn(Cc4ccc5nccn5c4)c3n2)cn1 CHEMBL3334542 IC50 6.0 nM
OCCn1cc(-c2cnc3nnn(Cc4n[nH]c5ncccc45)c3n2)cn1 CHEMBL3334549 IC50 6.0 nM
OCCn1cc(-c2cnc3nnn(Cc4ccc5nccn5c4)c3n2)cn1 CHEMBL3334550 IC50 6.0 nM
Fc1ccc(-c2cnc3nnn(Cc4n[nH]c5ncccc45)c3n2)cc1 CHEMBL3334564 IC50 6.0 nM
Cn1cc(-c2cnc3nnn(Cc4n[nH]c5ncccc45)c3n2)cn1 CHEMBL3334557 IC50 6.0 nM
N#Cc1cccc(-c2ccc(=O)n(C[C@@H]3CN(c4ncc(-c5cnn(CC6CCNCC6)c5)cn4)CCO3)n2)c1 CHEMBL3335777 IC50 6.0 nM
Cc1cc(NC(=O)C2(C(=O)Nc3ccc(F)cc3)CC2)ccc1-c1cccc2[nH]nc(N)c12 CHEMBL3394477 IC50 6.0 nM
CNC(=O)c1cccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)c1 CHEMBL3582290 IC50 6.0 nM
Cc1ccc2c(c1)oc(=O)n2CCOc1ccnc2cc(NCCCN3CCOCC3)ccc12 CHEMBL3786217 IC50 6.0 nM
COc1ccc2c(OCc3nnc4nnc(-c5ccccc5)nn34)ccnc2c1 CHEMBL3809634 IC50 6.0 nM
C/C(=N\NC(N)=S)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL3674493 IC50 6.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(C(C)c3cc4cccnc4cc3F)n2n1 CHEMBL3674504 IC50 6.0 nM
C/C(=N\OCCO)c1ccc2ncc([C@@H](C)c3cc4cccnc4cc3F)n2n1 CHEMBL3648230 IC50 6.0 nM
C/C(=N\OCCO)c1ccc2nnc(Cc3ccc4ncc(N5CCN(C)CC5)cc4c3)n2n1 CHEMBL3651404 IC50 6.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N[C@H]6CCNC6)cc5c4)n3c2)cn1 CHEMBL3703942 IC50 6.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NC6CC(C)(C)NC(C)(C)C6)cc5c4)n3c2)cn1 CHEMBL3703997 IC50 6.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NC6COC6)cc5c4)n3c2)cn1 CHEMBL3704003 IC50 6.0 nM
C/C(=N\OCCO)c1ccc2nnc(Sc3ccc4ncc(N5CC[C@H](N(C)C)C5)cc4c3)n2c1 CHEMBL3704012 IC50 6.0 nM
C/C(=N\O)c1ccc2nnc(Sc3ccc4ncc(N5CC[C@H](N(C)C)C5)cc4c3)n2c1 CHEMBL3704013 IC50 6.0 nM
CN1CCC(n2cc(-c3cnc(N4CCO[C@H](Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cn2)CC1 CHEMBL3965831 IC50 6.0 nM
CN1CCN(CCOc2ccc(-c3cnc(N4CCO[C@H](Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2)CC1 CHEMBL3971852 IC50 6.0 nM
CN1CCN(C(=O)c2ccc(-c3cnc(N4CCCC(Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2)CC1 CHEMBL3937128 IC50 6.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4c(F)cccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4462318 Kd(free) 6.0 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(OC5CCCC5)nn34)cc2s1 CHEMBL4460814 IC50 6.0 nM
C[C@@H](Oc1cncc(-c2cnn(C3CCNCC3)c2)c1)c1c(Cl)ccc(F)c1Cl CHEMBL4644985 IC50 6.0 nM
CC(=O)N1CCC(n2cc(-c3cncc(O[C@H](C)c4c(Cl)ccc(F)c4Cl)c3)cn2)CC1 CHEMBL4638327 IC50 6.0 nM
O=C(Nc1ccc(Oc2ccnc3c2CCN3)c(F)c1)c1c[nH]cc(-c2ccc(F)cc2)c1=O CHEMBL5414779 IC50 6.0 nM
C=C1CNCCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc21 CHEMBL3263973 IC50 6.1 nM
c1cnc2ccc(Cn3nnc4ncc(-c5cnn([C@@H]6CCNC6)c5)nc43)cc2c1 CHEMBL2170949 Ki 6.14 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc(=O)n(C)c5)nn34)ccnc2c1 CHEMBL3668166 Ki 6.2 nM
COc1cc2c(Oc3ccc(NC(=O)c4nccc(-c5ccccc5)n4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL2435975 IC50 6.23 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(F)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3593689 IC50 6.26 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)c(Cl)c1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1 CHEMBL4783511 IC50 6.26 nM
Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc1Oc1ccnc(NC(=O)C2CC2)c1 CHEMBL4476485 IC50 6.3 nM
C[C@@H](Oc1cc(-c2cnn(C3CC4(CNC4)C3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4111854 IC50 6.32 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)c1nnn(-c2ccc(F)cc2)c1C(F)(F)F CHEMBL3774862 IC50 6.39 nM
C=C1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc21 CHEMBL3263974 IC50 6.4 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C(C)CNCC3)ncc1Cl CHEMBL3263979 IC50 6.4 nM
Cc1ccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)cc1F CHEMBL4583172 IC50 6.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc5cccnc5n(-c5ccc(Br)cc5F)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4286303 IC50 6.41 nM
COC(=O)c1ccc(/C=N/CNC(C)c2ccc3ncccc3c2)cc1F CHEMBL4541607 EC50 6.41 nM
O=[N+]([O-])c1cccc(CNc2nc(C(F)(F)F)nc3ncc(-c4cnn(C5CCNCC5)c4)cc23)c1 CHEMBL2148143 IC50 6.5 nM
C/C=C1\CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc21 CHEMBL3263975 IC50 6.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl CHEMBL3356906 IC50 6.5 nM
CN(C)CCCOc1cnc(-c2cccc(Cn3nc(-c4cccc(F)c4)ccc3=O)c2)nc1 CHEMBL3402757 IC50 6.5 nM
COc1ccc2c(OCc3nnc4ccc(-c5cn(C)nn5)cn34)ccnc2c1 CHEMBL3663582 Ki 6.6 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(F)c(Cl)c5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3593887 IC50 6.67 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL2385198 IC50 6.68 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5Cl)nn4)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3824101 IC50 6.68 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)n2)c1 CHEMBL3287310 IC50 6.7 nM
Nc1noc2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(Cl)cc5)CC4)cc3)c12 CHEMBL3394451 IC50 6.7 nM
C/C(=N\OCCO)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1 CHEMBL3648228 IC50 6.7 nM
CC(Oc1cc(-c2cn(C3CCNCC3)nn2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL3639463 IC50 6.7 nM
COc1cnc2c(NCc3nnc4ccc(-c5cnn(C(C)C)c5)nn34)ccnc2c1 CHEMBL3668131 Ki 6.7 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc6c(c5)CN(C)C6=O)nn34)ccnc2c1 CHEMBL3668175 Ki 6.7 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cn[nH]c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5203752 IC50 6.7 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccc(Cl)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4085110 IC50 6.76 nM
O=c1c(-c2ccc(F)cc2)c[nH]c2ccnc(Nc3ccc(Oc4ccnc5cc(OCCO)ccc45)c(F)c3)c12 CHEMBL4760632 IC50 6.8 nM
Cn1cc(-c2cnc3ccc(CCn4nc(-c5cccc(Br)c5)ccc4=O)cc3c2)cn1 CHEMBL5172458 IC50 6.8 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(Cl)c5ccccc5n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3780662 IC50 6.84 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)[C@H](C)N)c2)ncc1Cl CHEMBL3357444 IC50 6.9 nM
c1ccc(COc2ccc(-c3cnc4nnc(Cc5ccc6ncccc6c5)n4n3)cc2)cc1 CHEMBL3798542 IC50 6.9 nM
Nc1nc(-c2c[nH]c3nccc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)cs1 CHEMBL502283 IC50 7.0 nM
COc1ccc2c(OCc3nnc4ccc(-c5cc(F)cc(F)c5)nn34)ccnc2c1 CHEMBL494630 IC50 7.0 nM
COc1ccc2c(OCc3nnc4ccc(-c5cccc(F)c5)nn34)ccnc2c1 CHEMBL494793 IC50 7.0 nM
COc1cnc2c(NCc3nnc4ccc(-c5ccc(F)c(F)c5)nn34)ccnc2c1 CHEMBL566242 IC50 7.0 nM
O=C(Nc1ccc(F)cc1F)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL1095873 IC50 7.0 nM
CCC(=O)N1CCC(n2cc(-c3cnc(N)c(-c4nc5ccccc5o4)c3)cn2)CC1 CHEMBL1170926 IC50 7.0 nM
CN1C(=O)CCCc2cc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)ccc21 CHEMBL1644798 IC50 7.0 nM
O=C(Cc1ccc(O)cc1)N/N=C1\C(=O)Nc2ccc(S(=O)(=O)Cc3c(Cl)cccc3Cl)cc21 CHEMBL1822382 IC50 7.0 nM
O=c1[nH]ccc2c(Cc3nnc4ccc(-c5cccc(Cl)c5)nn34)cccc12 CHEMBL1922415 IC50 7.0 nM
CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)NC(=O)[C@H](NC(=O)OC)CC3(C)C)ncc1Cl CHEMBL1939493 IC50 7.0 nM
Cc1csc(-n2ccc3nnn([C@@H](C)c4ccc5ncccc5c4)c3c2=O)c1 CHEMBL2029681 IC50 7.0 nM
Cc1ccc(-n2ccc3nnn([C@@H](C)c4ccc5ncccc5c4)c3c2=O)s1 CHEMBL2029682 IC50 7.0 nM
Cc1ccc(Cl)c2c1[nH]c1nc3nnc(Cc4ccc(O)cc4)n3nc12 CHEMBL2170956 IC50 7.0 nM
N[C@@H]1CCN(c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)C1 CHEMBL2170806 Ki 7.0 nM
Oc1ccc(Cc2nnc3ncc(-c4ccc(F)cc4)nn23)cc1 CHEMBL2170957 IC50 7.0 nM
CC(C)Nc1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1 CHEMBL2431836 Ki 7.0 nM
CNC(=O)c1ccc(-c2ccc3nnc([C@@H](C)c4ccc5ncccc5c4)n3n2)cc1 CHEMBL2431830 Ki 7.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3263958 IC50 7.0 nM
N#Cc1ccc(-c2cnc3nnn(Cc4n[nH]c5ncccc45)c3n2)cn1 CHEMBL3334562 IC50 7.0 nM
Fc1ccc(-c2cnc3nnn(Cc4ccc5nccn5c4)c3n2)cc1 CHEMBL3334565 IC50 7.0 nM
CN1CCC(n2cc(-c3cnc(N4CCO[C@H](Cn5nc(-c6cccc(F)c6)ccc5=O)C4)nc3)cn2)CC1 CHEMBL3335769 IC50 7.0 nM
O=c1ccc(-c2cccc(F)c2)nn1C[C@@H]1CN(c2ncc(-c3cnn(C4CCN(CCO)CC4)c3)cn2)CCO1 CHEMBL3335766 IC50 7.0 nM
Cc1cc(-c2cc(F)c3nnc([C@@H](C)c4ccc5ncccc5c4)n3c2)sn1 CHEMBL3414920 IC50 7.0 nM
COc1ccc2c(OCc3nnc4c(F)cc(-c5ccccc5)cn34)ccnc2c1 CHEMBL3414731 IC50 7.0 nM
COc1cccc(-c2c(C(=O)Nc3ccc(Oc4ccnc5cc(-c6cn(C)cn6)sc45)c(F)c3)cnn2-c2ccccc2)c1 CHEMBL3608550 IC50 7.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(C(C)c3c(F)cc4c(cnn4C)c3F)n2n1 CHEMBL3674506 IC50 7.0 nM
C/C(=N\n1cc(O)[nH]c1=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3956952 IC50 7.0 nM
CCO/N=C(\C)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1 CHEMBL3651387 IC50 7.0 nM
C/C(=N\OC1COC1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3651411 IC50 7.0 nM
CC1=NC(C)=C(C#N)C(c2ccc3[nH]nc(SCc4ccccc4)c3c2)C1C#N CHEMBL3648320 IC50 7.0 nM
[C-]#[N+]C1=C(C(F)(F)F)N=C2COC(=O)C2C1c1ccc2n[nH]c(C)c2c1 CHEMBL3685755 IC50 7.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCCC(NC(=O)OC(C)(C)C)C6)cc5c4)n3c2)cn1 CHEMBL3703946 IC50 7.0 nM
C/C(=N\OCCO)c1ccc2nnc(Sc3ccc4ncc(N5CCC(O)CC5)cc4c3)n2c1 CHEMBL3704007 IC50 7.0 nM
COc1cnc2c(NCc3nnc4ccc(-c5cnc(C)s5)nn34)ccnc2c1 CHEMBL3668188 Ki 7.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC[C@@H](C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C CHEMBL4107720 IC50 7.0 nM
CN1CCN(CCOc2cnc(N3CCO[C@H](Cn4nnc5ncc(-c6cnn(C)c6)nc54)C3)nc2)CC1 CHEMBL3980136 IC50 7.0 nM
CC(=O)N1CCN(Cc2ccc(-c3cnc(N4CCCC(Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2)CC1 CHEMBL3955891 IC50 7.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 7.0 nM
Clc1cccc(Nc2nn3c(Cc4ccc5ncccc5c4)nnc3s2)c1 CHEMBL4784332 Ki 7.0 nM
Cc1ccc2oc(SCCC(=O)Nc3ccc(S(=O)(=O)NC(=O)NC4CCCCC4)cc3)nc2c1 CHEMBL5404166 IC50 7.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)c3cc4cccnc4n(-c4ccccc4)c3=O)cc2)ccn1 CHEMBL4209961 IC50 7.06 nM
CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)OC(C)(C)C)c2)ncc1Cl CHEMBL3356907 IC50 7.1 nM
C/C(=N\OCCO)c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 CHEMBL3651419 IC50 7.1 nM
Cn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc21 CHEMBL4584949 IC50 7.1 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5c4c(=O)c(-c4ccc(F)cc4)cn5C)cc3F)c2cc1OC CHEMBL4799551 IC50 7.1 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4858468 IC50 7.1 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)c(Cl)c1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(F)c1 CHEMBL4789479 IC50 7.18 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c([C@@H]5CCCN5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL2031909 Ki 7.2 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C(C)CN(CC(=O)N(C)C)CC3)ncc1Cl CHEMBL3263980 IC50 7.2 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1nnn(-c2ccccc2)c1C(F)(F)F CHEMBL3774954 IC50 7.25 nM
Cn1cc(-c2cnc(Nc3cccc(Cn4nc(-c5ccc(S(C)(=O)=O)cc5)ccc4=O)c3)nc2)cn1 CHEMBL3758564 IC50 7.3 nM
CO/N=C(\C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3648235 IC50 7.3 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)c(F)c2)c2c(N)ncnc21 CHEMBL4877502 IC50 7.3 nM
CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2c1 CHEMBL4747900 IC50 7.4 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(CCOC)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5179628 IC50 7.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5)cc(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4798120 IC50 7.42 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccc(F)c(F)c5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3593885 IC50 7.43 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(Cl)cc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4763363 IC50 7.43 nM
CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)NC(C)(C)C)c2)ncc1Cl CHEMBL3357438 IC50 7.5 nM
Cn1cc(-c2cnc(Nc3cccc(Cn4nc(-c5cnn(C)c5)ccc4=O)c3)nc2)cn1 CHEMBL3759079 IC50 7.5 nM
COc1cnc2ccc(Cc3nnc4ccc(-c5ccccc5)nn34)cc2c1 CHEMBL3663592 Ki 7.5 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc6c(c5)OC(C)(C)C6)nn34)ccnc2c1 CHEMBL3668170 Ki 7.5 nM
COC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)cc1 CHEMBL5179900 IC50 7.5 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccccc5C(F)(F)F)C4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3116219 IC50 7.51 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(C)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL2385178 IC50 7.54 nM
COc1ccc2c(OCCn3c(=O)oc4cc(C)ccc43)ccnc2c1 CHEMBL3786924 IC50 7.6 nM
CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1 CHEMBL4786853 IC50 7.6 nM
Cn1cc(-c2cnc3ccc(CCn4nc(-c5cc(F)c(F)c(F)c5)ccc4=O)cc3c2)cn1 CHEMBL5192592 IC50 7.6 nM
C[C@@H](Sc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL2442124 IC50 7.7 nM
CCC(c1ccc2ncccc2c1F)n1cnc2ncc(-c3ccc(C(=O)NC)c(F)c3)nc21 CHEMBL4521417 EC50 7.7 nM
COCCOc1cc2nccc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)c2cc1OC CHEMBL4799428 IC50 7.7 nM
Cn1cc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cn1 CHEMBL3582279 IC50 7.8 nM
Cc1c(C(=O)NCCCN2CCOCC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4285034 IC50 7.8 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4cccc(Cl)c4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4795132 IC50 7.86 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL459647 Ki 7.9 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)n2)c1 CHEMBL3287304 IC50 7.9 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc6c(c5c4)OCC(=O)N6)n3c2)cn1 CHEMBL3819436 IC50 7.9 nM
COc1ccc2c(OCc3nnc4ccc(C(N)=O)cn34)ccnc2c1 CHEMBL3668150 Ki 7.9 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OCC(C)(C)O CHEMBL4792576 IC50 7.9 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 7.943 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 7.943 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 7.943 nM
COc1cc2c(Oc3ccc(NC(=O)c4nccc(-c5ccc(F)cc5)n4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL2435961 IC50 7.96 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc5cccnc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4282570 IC50 7.97 nM
Nc1cc(Oc2ccc(Nc3ncccc3C(=O)Nc3ccc(F)cc3F)cc2F)ccn1 CHEMBL1097142 IC50 8.0 nM
CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)CCN(CCOC)CC3)ncc1Cl CHEMBL1642135 IC50 8.0 nM
O=C(Cc1ccc(O)cc1)N/N=C1\C(=O)Nc2cccc(Cl)c21 CHEMBL1823250 IC50 8.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(O)c(-c3cnccn3)c2o1 CHEMBL2032282 IC50 8.0 nM
COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c43)cc2c1 CHEMBL2029685 IC50 8.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NC5CCCCC5)cc4c(=O)c3c2)cn1 CHEMBL2323782 IC50 8.0 nM
Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5cccnc5)cc4c(=O)c3c2)cn1 CHEMBL2323773 IC50 8.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccc(C#N)cc3)nn12 CHEMBL2431827 Ki 8.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccc(N(C)C)nc3)nn12 CHEMBL2431833 Ki 8.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(N3CCCC3)cc2o1 CHEMBL3093151 IC50 8.0 nM
FC(F)(F)Cn1cc(-c2cnc3nnn(Cc4n[nH]c5ncccc45)c3n2)cn1 CHEMBL3334552 IC50 8.0 nM
N#Cc1cccc(-c2ccc(=O)n(C[C@@H]3CN(c4ncc(-c5cnn(CCO)c5)cn4)CCO3)n2)c1 CHEMBL3335775 IC50 8.0 nM
C/C(=N\OCCO)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1 CHEMBL3648223 IC50 8.0 nM
C/C(=N\OCCO)c1cnc2ccc(Cn3nnc4ncc(/C(C)=N/OCCO)nc43)cc2c1 CHEMBL3651408 IC50 8.0 nM
COc1n[nH]c2ccc(C3C(C#N)=C(C)N=C(C)C3C#N)cc12 CHEMBL3639471 IC50 8.0 nM
COCCN(C)c1n[nH]c2ccc(C3C(C#N)=C(C)N=C(C)C3C#N)cc12 CHEMBL3648326 IC50 8.0 nM
CN1CCN(Cc2cnc3ccc(Sc4nnc5ccc(-c6cnn(C)c6)cn45)cc3c2)CC1 CHEMBL3703943 IC50 8.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCCNCC6)cc5c4)n3c2)cn1 CHEMBL3703954 IC50 8.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(NCCO)cc5c4)n3c2)cn1 CHEMBL3703989 IC50 8.0 nM
Cn1cc(-c2cc(F)c3nnc(Sc4ccc5ncc(NC6COC6)cc5c4)n3c2)cn1 CHEMBL3703998 IC50 8.0 nM
C/C(=N\OCCO)c1ccc2nnc(Sc3ccc4ncc(NC5CCOCC5)cc4c3)n2c1 CHEMBL3704014 IC50 8.0 nM
C/C(=N\O)c1ccc2nnc(Sc3ccc4ncc(NC5CCOCC5)cc4c3)n2c1 CHEMBL3704015 IC50 8.0 nM
CC(=O)N1CCN(Cc2ccc(-c3cnc(N4CCOC(Cn5nnc6ncc(-c7cnn(C)c7)nc65)C4)nc3)cc2)CC1 CHEMBL3928276 IC50 8.0 nM
CN1CCN(Cc2ccc(-c3cnc(N4CCOC(Cn5nnc6ncc(-c7cccc(C#N)c7)nc65)C4)nc3)cc2)CC1 CHEMBL3921681 IC50 8.0 nM
CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C(F)(F)F)N1C CHEMBL3980618 IC50 8.0 nM
Oc1ccc(Cc2nnc3sc(Nc4cccc(Cl)c4)nn23)cc1 CHEMBL4753090 Ki 8.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4084146 IC50 8.03 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccccc5C(F)(F)F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3594102 IC50 8.1 nM
CC(C)n1cc(-c2cnc(Nc3cccc(Cn4nc(-c5cnn(C)c5)ccc4=O)c3)nc2)cn1 CHEMBL3759336 IC50 8.1 nM
O=C(Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1)C1CC1 CHEMBL4434974 IC50 8.1 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OCCCN1CCCC1 CHEMBL4790015 IC50 8.1 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccccc4Cl)C(C)(C)C)cc3F)c2cc1OC CHEMBL4795991 IC50 8.12 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccccc5C(F)(F)F)C4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3116235 IC50 8.14 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)c(Cl)c1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCCCC4)c(OC)cc23)c(F)c1 CHEMBL4783902 IC50 8.14 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(Cc2ccc(F)cc2)c1=O CHEMBL453850 IC50 8.2 nM
O=C(Nc1ccc(Oc2ccncc2-c2cccnc2)c(F)c1)C1=NN(c2cccc(F)c2)c2ccccc2S1(=O)=O CHEMBL3975648 IC50 8.2 nM
Cc1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)cc1 CHEMBL5208989 IC50 8.2 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)c(Cl)c1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1 CHEMBL4795003 IC50 8.22 nM
CCNC(=O)c1cc(Oc2ccc(NC(=O)c3cc4cccnc4n(-c4ccc(F)cc4)c3=O)cc2)ccn1 CHEMBL4214671 IC50 8.24 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5OC(F)(F)F)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3290903 IC50 8.27 nM
O=C(NCc1ccccn1)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F CHEMBL3582302 IC50 8.3 nM
COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ncnc2cc1OCCCN1CCCC1 CHEMBL4784644 IC50 8.3 nM
CCCNC(=O)c1cc(Oc2ccc(NC(=O)c3cc4cccnc4n(-c4ccccc4F)c3=O)cc2)ccn1 CHEMBL4214315 IC50 8.32 nM
COc1cc2c(Oc3ccc(CC(=O)N/N=C/c4ccc(OC(F)(F)F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3339353 IC50 8.34 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)cc5F)C4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3116233 IC50 8.35 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccccc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4777622 IC50 8.35 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)c(Cl)c1)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1 CHEMBL4795288 IC50 8.38 nM
COCCOc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1 CHEMBL4740288 IC50 8.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)cc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2385185 IC50 8.42 nM
Cc1cc(=O)n(-c2ccc(F)cc2)nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1 CHEMBL4104755 IC50 8.42 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccccc5C)c4C)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343363 IC50 8.48 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)c1cc2cccnc2n(-c2ccc(F)cc2)c1=O CHEMBL4280004 IC50 8.53 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(Cl)CCCN(c5ccc(F)cc5)C4=O)cc3F)c2cc1OC CHEMBL5265812 IC50 8.6 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(OC(F)F)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3954957 IC50 8.66 nM
O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(-c5cccc(F)c5)nn34)cc2s1 CHEMBL4537541 Kd 8.7 nM
CCC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3cn[nH]c3)nc21 CHEMBL4576153 EC50 8.7 nM
Cn1cc(-c2cnc3ccc(CCn4nc(-c5cccc(N)c5)ccc4=O)cc3c2)cn1 CHEMBL5171999 IC50 8.7 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5)nn4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3823944 IC50 8.75 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccccc5)CC4)cc3)n2)c1 CHEMBL3287303 IC50 8.8 nM
COc1cc2c(Oc3ccc(-c4cnc(Cc5ccccc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL505896 Ki 8.9 nM
COc1cc2nccc(Oc3ccc(-c4cnc(Cc5ccccc5)n(C)c4=O)cc3F)c2cc1OC CHEMBL461648 INH 8.9 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccncc5)nn34)ccnc2c1 CHEMBL3668172 Ki 8.9 nM
COc1cnc2c(NCc3nnc4c(F)cc(-c5cnc(C)s5)cn34)ccnc2c1 CHEMBL3668183 Ki 8.9 nM
C[C@@H](Oc1cc(-c2cnn(C3CC4(CCNCC4)C3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4113696 IC50 8.9 nM
Cc1cccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)c1 CHEMBL5171761 IC50 8.9 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(C)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343367 IC50 8.91 nM
COc1cc2c(Oc3ccc(NC(=S)N/N=C/c4ccccc4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3764158 IC50 8.92 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccccc5)nn34)ccnc2c1 CHEMBL496102 IC50 9.0 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc(F)c(F)c5)nn34)ccnc2c1 CHEMBL522196 IC50 9.0 nM
O=S(=O)(c1cccc2nonc12)n1ccc2ncc(-c3cnn(C4CCNCC4)c3)cc21 CHEMBL554497 IC50 9.0 nM
O=S(=O)(c1c(Cl)nc2sccn12)n1ccc2ncc(-c3cnn(C4CCNCC4)c3)cc21 CHEMBL564371 IC50 9.0 nM
O=C(Nc1ccccc1CCO)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL1097543 IC50 9.0 nM
O=C(Nc1ccc(F)cc1F)c1cc(Br)cnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL1097868 IC50 9.0 nM
CSc1ncc(C(=O)Nc2ccc(F)cc2F)c(Nc2ccc(Oc3ccnc(N)c3)c(F)c2)n1 CHEMBL1096536 IC50 9.0 nM
CC1=C(C(=O)N2CCCC2CN2CCCC2)C(C)C(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)=N1 CHEMBL1822004 IC50 9.0 nM
CCc1cc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2cc1O CHEMBL2032278 IC50 9.0 nM
OCCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL2170955 Ki 9.0 nM
CN1CCC(n2cc(-c3cnc(N4CCO[C@H](Cn5nc(-c6ccc(F)c(Cl)c6)ccc5=O)C4)nc3)cn2)CC1 CHEMBL3335772 IC50 9.0 nM
CN1CCN(CCCOC(=O)Nc2cccc(Cn3nc(-n4ccc5ccc(F)cc54)ccc3=O)c2)CC1 CHEMBL3417482 IC50 9.0 nM
Cc1cc(-c2cc(F)c3nnc(C(F)(F)c4ccc5ncccc5c4)n3c2)on1 CHEMBL3414736 IC50 9.0 nM
COc1cnc2ccc([C@H](C)c3nnc4c(F)cc(-c5cc(C)ns5)cn34)cc2c1 CHEMBL3414921 IC50 9.0 nM
COc1cnc2ccn([C@H](C)c3nnc4ccc(-c5cnn(C)c5)cn34)c(=O)c2c1 CHEMBL3785374 IC50 9.0 nM
O=C(Cc1ccc(O)c(Cl)c1)N/N=C1\C(=O)Nc2c(Cl)ccc(Cl)c21 CHEMBL3982132 IC50 9.0 nM
O=C(Cc1ccc(O)c(F)c1)N/N=C1\C(=O)Nc2c(Cl)ccc(Cl)c21 CHEMBL3969990 IC50 9.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(C(O)c3cc4cccnc4cc3F)n2n1 CHEMBL3674497 IC50 9.0 nM
C/C(=N\NC(N)=O)c1ccc2ncc(C(O)c3ccc4ncccc4c3)n2n1 CHEMBL3674498 IC50 9.0 nM
CCC(=O)N/N=C(\C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL3674552 IC50 9.0 nM
C/C(=N\N1CCNC1=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 CHEMBL4114743 IC50 9.0 nM
C/C(=N\OCC(O)CO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 CHEMBL3648246 IC50 9.0 nM
OCCn1cc(-c2ncc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1 CHEMBL3660148 IC50 9.0 nM
[C-]#[N+]C1C(C)=NC2=C(C(=O)OC2)C1c1ccc2[nH]nc(-c3ccc(OC(C)C)nc3)c2c1 CHEMBL3685757 IC50 9.0 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(N6CCC(NC(=O)OC(C)(C)C)C6)cc5c4)n3c2)cn1 CHEMBL3703938 IC50 9.0 nM
CC1=C(C#N)C(c2cc3c(C)n[nH]c3cc2F)C(C#N)=C(C(F)F)N1 CHEMBL3901014 IC50 9.0 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3)c2cc1OC CHEMBL4784431 IC50 9.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)C(C)c4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL5410219 IC50 9.0 nM
Cn1cc(-c2ccc3nnc(Cc4ccc5ncccc5c4)n3n2)cn1 CHEMBL2431841 Ki 9.1 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(NC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4800700 IC50 9.12 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(F)cc1)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1 CHEMBL4799667 IC50 9.12 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)c(F)c5)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3290896 IC50 9.16 nM
COc1cc2c(Oc3ccc(-c4cnc(Cc5ccccc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL449833 Ki 9.2 nM
c1csc(-c2ccc3nnc(COc4ccnc5ccccc45)n3n2)c1 CHEMBL3668160 Ki 9.2 nM
Cc1c(C(=O)NCCCN(C)C)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4292884 IC50 9.2 nM
Cc1cc(=O)n(-c2ccc(F)cc2)nc1C(=O)Nc1ccc(Oc2ccnc3c2ccn3C)cc1 CHEMBL4068286 IC50 9.21 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)c1cc2cccnc2n(-c2ccc(Cl)cc2)c1=O CHEMBL4287907 IC50 9.25 nM
COc1cc2c(Oc3ccc(N/C=C4\C(=O)NC(=O)N(c5ccc(F)cc5F)C4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3116238 IC50 9.27 nM
C[C@@H](Oc1ccc2ncc(C3CC3C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl CHEMBL602472 IC50 9.3 nM
Cn1cc(-c2ccc3nnc(Sc4ccc5ncc6c(c5c4)OCC(=O)N6)n3c2)cn1 CHEMBL3818738 IC50 9.3 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccc(-c6nc(C)no6)c(Cl)c5)nn34)ccnc2c1 CHEMBL3663581 Ki 9.3 nM
CCC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3cnn(CCO)c3)nc21 CHEMBL4539073 EC50 9.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccccc5)ccn4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL2435969 IC50 9.37 nM
COc1cc(OC)cc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ccnc(N)c4Cl)c(F)c3)cc3ccccc32)c1 CHEMBL4542515 IC50 9.4 nM
CCC(c1cc2cccnc2cc1F)n1cnc2ncc(-c3ccc(C(=O)NC)c(F)c3)nc21 CHEMBL4563384 EC50 9.4 nM
COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2cc1OCC1CCN(C)CC1 CHEMBL4762933 IC50 9.4 nM
CCN(CC)CCCOc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ncnc2cc1OC CHEMBL4787904 IC50 9.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5)nn4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3823376 IC50 9.45 nM
COc1ccc2c(OCc3nnc4ccc(-c5ccccn5)cn34)ccnc2c1 CHEMBL3668179 Ki 9.5 nM
O=c1c(-c2ccc(F)cc2)c[nH]c2ccnc(Nc3ccc(Oc4ncnc5cc6c(cc45)OCCOCCOCCO6)c(F)c3)c12 CHEMBL4786987 IC50 9.5 nM
COc1cc2c(Oc3ccc(-c4cnc(Cc5ccc(C)cc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL452680 Ki 9.6 nM
CCO/N=C(\C)c1cc(F)c2ncc(Cc3ccc4ncccc4c3)n2c1 CHEMBL3582289 IC50 9.7 nM
Nc1nccc(Oc2ccc(NC(=O)c3cc4ccccc4n(-c4ccc(F)cc4)c3=O)cc2F)c1Cl CHEMBL4571149 IC50 9.7 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OC CHEMBL4794496 IC50 9.7 nM
CN1CCN(CCCOc2cnc(-c3cccc(Cn4nc(-n5ccc6ccc(F)cc65)ccc4=O)c3)nc2)CC1 CHEMBL3417486 IC50 9.8 nM
COc1ccc2c(OCCn3c(=O)oc4cc(N)ccc43)ccnc2c1 CHEMBL3785213 IC50 9.8 nM
O=C(Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1)C1CCCCC1 CHEMBL4469760 IC50 9.8 nM
Nc1nccc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)c1Cl CHEMBL4580644 IC50 9.8 nM
COc1cc2c(Oc3ccc(NC(=O)NS(=O)(=O)Cc4ccccc4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4576201 IC50 9.87 nM
CCCNC(=O)c1cc(Oc2ccc(NC(=O)c3cc4cccnc4n(-c4ccccc4)c3=O)cc2)ccn1 CHEMBL4207773 IC50 9.89 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5OC)cn4)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3977027 IC50 9.9 nM
Nc1nccc(Oc2ccc(Nc3nccc4ccn(-c5ccc(F)cc5)c(=O)c34)cc2F)c1Cl CHEMBL4474232 IC50 9.9 nM
O=C(CO)Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1 CHEMBL4575352 IC50 9.9 nM
Cn1cc(-c2cnc3ncn(Cc4ccc5ncccc5c4)c3n2)cn1 CHEMBL3334553 EC50 9.9 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CC(F)(F)c3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5175023 IC50 9.9 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)cc5Cl)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL3290899 IC50 9.95 nM
CCN1CCN(CCCOc2cc3nccc(Oc4c(F)cc(NC(=O)NN5C(=O)CS[C@@H]5c5ccc(F)cc5F)cc4F)c3cc2OC)CC1 CHEMBL5433417 IC50 9.95 nM