c1ccc(CSc2nnc(Nc3cccnc3)[nH]2)cc1 CHEMBL241829 Ki app 0.04 nM
Cc1ccccc1Nc1nnc(SCc2ccccc2)[nH]1 CHEMBL243306 Ki app 0.04 nM
COc1ccc(Nc2nnc(SCc3ccccc3)[nH]2)cc1 CHEMBL397477 Ki app 0.05 nM
Cc1ccc(Nc2nnc(SCc3ccccc3)[nH]2)cc1 CHEMBL243111 Ki app 0.07 nM
CO[C@@H]1[C@H](OC(=O)N[C@@H](C(N)=O)C(C)C)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL3527358 EC50 0.095 nM
COc1ccc(Nc2nnc(SCc3ccccc3F)[nH]2)cc1 CHEMBL242435 Ki app 0.13 nM
CC(C)=CCSc1nnc(Nc2ccccc2C)[nH]1 CHEMBL245022 Ki app 0.15 nM
COc1ccc(Nc2nnc(SCC=C(C)C)[nH]2)cc1 CHEMBL245226 Ki app 0.16 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc2N1 CHEMBL4475680 Ki 0.16 nM
O=C1CCC(N2Cc3cc(C4CCN(C(=O)CCCCCN5CCC(c6ccc(Oc7nn8cnnc8c8c7CCCC8)cc6)CC5)CC4)ccc3C2=O)C(=O)N1 CHEMBL5465171 DC50 0.2 nM
Cc1ccccc1Nc1nnc(SCc2ccccc2F)[nH]1 CHEMBL389087 Ki app 0.23 nM
Fc1ccccc1CSc1nnc(Nc2cccnc2)[nH]1 CHEMBL242050 Ki app 0.3 nM
CO[C@@H]1[C@H](OC(=O)N[C@@H](C(N)=O)C(C)(C)O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL3527591 EC50 0.3 nM
CO[C@@H]1[C@H](OC(N)=O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL176975 IC50 0.39 nM
CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL562231 IC50 0.4 nM
COC(=O)c1ccc(Nc2nnc(SCc3ccccc3F)[nH]2)cc1 CHEMBL242875 Ki app 0.41 nM
CO[C@@H]1[C@H](OC(=O)NC(=O)Cl)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL368349 IC50 0.43 nM
Clc1ccc(Nc2nnc(SCc3ccccc3)[nH]2)cc1 CHEMBL242028 Ki app 0.43 nM
c1ccc(CSc2nnc(Nc3ccccc3)[nH]2)cc1 CHEMBL243303 Ki app 0.5 nM
Fc1ccc(CSc2nnc(Nc3cccnc3)[nH]2)cc1F CHEMBL242051 Ki app 0.5 nM
COC(=O)c1ccc(Nc2nnc(SCC=C(C)C)[nH]2)cc1 CHEMBL243101 Ki app 0.5 nM
CO[C@@H]1[C@H](OC(C)=O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL172123 IC50 0.51 nM
CC(C)=CCSc1nnc(Nc2ccc(Cl)cc2)[nH]1 CHEMBL242891 Ki app 0.52 nM
Fc1ccccc1CSc1nnc(Nc2ccc(Cl)cc2)[nH]1 CHEMBL242462 Ki app 0.61 nM
CO[C@@H]1[C@H](OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL32838 IC50 0.63 nM
Cc1ccc(Nc2nnc(SCc3ccccc3F)[nH]2)cc1 CHEMBL243320 Ki app 0.65 nM
COC(=O)c1ccc(Nc2nnc(SCc3ccccc3)[nH]2)cc1 CHEMBL242663 Ki app 0.7 nM
c1ccc(Nc2nnc(SCc3cccs3)[nH]2)cc1 CHEMBL243305 Ki app 0.75 nM
CCN1CCN(C(=O)O[C@@H]2CC[C@]3(CO3)[C@@H](/C(C)=N/OCC3CCCCC3)[C@@H]2OC)CC1 CHEMBL367938 IC50 0.8 nM
COC(=O)c1ccc(Nc2nnc(SCc3cc(C)on3)[nH]2)cc1 CHEMBL396988 Ki app 0.8 nM
O=C(NCc1cc(F)cc(F)c1)[C@@]1(O)CCN(c2cnc3[nH]ccc3c2)C1=O CHEMBL4451402 Kd 0.88 nM
COC(=O)c1ccc(Nc2nnc(SCc3ccncc3)[nH]2)cc1 CHEMBL430001 Ki app 0.9 nM
COC(=O)c1ccc(Nc2nnc(SCc3ccccn3)[nH]2)cc1 CHEMBL242876 Ki app 0.9 nM
COc1ccc(Nc2nnc(SCC=C(C)C)[nH]2)cc1OC CHEMBL242447 Ki app 0.9 nM
COc1cc(/C=C/C(=O)O[C@@H]2CC[C@]3(CO3)[C@@H]([C@@]3(C)O[C@@H]3CC=C(C)C)[C@@H]2OC)cc(OC)c1OC CHEMBL137766 IC50 0.96 nM
Ic1ccc(-c2c[nH]nn2)cc1 CHEMBL364051 Ki app 1.0 nM
Brc1ccc(-c2c[nH]nn2)cc1Br CHEMBL195915 Ki app 1.0 nM
CO[C@@H]1[C@H](OC(=O)NC(=O)CCl)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL424278 IC50 1.0 nM
CC(C)=CCSc1nnc(Nc2ccccc2)[nH]1 CHEMBL230640 Ki app 1.0 nM
O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2cnc3[nH]ccc3c2)C1=O CHEMBL4448724 Kd 1.14 nM
CO[C@@H]1[C@H](OC(N)=O)CC[C@]2(CO2)[C@H]1/C(C)=N/OCc1ccccc1 CHEMBL172883 IC50 1.2 nM
CO[C@@H]1[C@H](OC(C)=O)CC[C@]2(CO2)[C@H]1/C(C)=N/OCc1ccccc1 CHEMBL174250 IC50 1.2 nM
CC(C)=CCSc1nnc(Nc2ccc(C)cc2)[nH]1 CHEMBL398002 Ki app 1.2 nM
COC(=O)c1ccc(Nc2nnc(SCc3ccc(F)c(F)c3)[nH]2)cc1 CHEMBL396742 Ki app 1.3 nM
COc1ccc(Nc2nnc(SCc3ccccc3F)[nH]2)cc1OC CHEMBL243746 Ki app 1.3 nM
CO[C@@H]1[C@H](OC(=O)N[C@@H](C(N)=O)C(C)C)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@H]1OC1(C)C CHEMBL3526173 EC50 1.3 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCC(O)C3)cc2n1CC(F)(F)F CHEMBL3973816 IC50 1.46 nM
Cc1cc(CSc2nnc(Nc3cccnc3)[nH]2)no1 CHEMBL395100 Ki app 1.5 nM
Fc1ccc(CSc2nnc(Nc3ccc(Cl)cc3)[nH]2)cc1F CHEMBL242464 Ki app 1.5 nM
COc1ccc(Nc2nnc(SCc3cc(C)on3)[nH]2)cc1 CHEMBL245227 Ki app 1.6 nM
CO[C@@H]1[C@H](OC(N)=O)CC[C@]2(CO2)[C@H]1/C(C)=C/CC=C(C)C CHEMBL369152 IC50 1.7 nM
Cc1ccccc1CSc1nnc(Nc2cccnc2)[nH]1 CHEMBL242049 Ki app 1.7 nM
COc1ccc(Nc2nnc(SCc3ccccc3)[nH]2)cc1OC CHEMBL245228 Ki app 1.7 nM
Cc1cc(CSc2nnc(Nc3ccc(Cl)cc3)[nH]2)no1 CHEMBL243117 pKi 1.778 nM
CC(C)c1ccccc1Nc1nc(SCc2cccs2)n[nH]1 CHEMBL230641 Ki app 2.0 nM
O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ccccn2)c1 CHEMBL4456585 Kd 2.0 nM
COc1ccc(Nc2nnc(SCc3ccc(F)c(F)c3)[nH]2)cc1 CHEMBL242646 Ki app 2.1 nM
O=C(NCc1cc(F)cc(F)c1)[C@@]1(O)CCN(c2ccc3[nH]ccc3c2)C1=O CHEMBL4464946 Kd 2.1 nM
O=c1c2cn[nH]c2c2ccc(-c3ccc(N4CCNCC4)cc3)cc2n1CC(F)(F)F CHEMBL3930227 IC50 2.13 nM
Cc1ccccc1Nc1nnc(SCc2ccc(F)c(F)c2)[nH]1 CHEMBL397244 Ki app 2.4 nM
Clc1ccc(Nc2nnc(SCc3ccncc3)[nH]2)cc1 CHEMBL242678 Ki app 2.5 nM
Cc1ccccc1CSc1nnc(Nc2ccccc2C)[nH]1 CHEMBL396468 Ki app 2.5 nM
COC(=O)c1ccc(Nc2nnc(SCC3CCCCC3)[nH]2)cc1 CHEMBL243100 Ki app 2.7 nM
Brc1ccc(-c2c[nH]nn2)cc1 CHEMBL194429 Ki app 3.0 nM
Cc1ccc(-c2c[nH]nn2)nc1 CHEMBL194520 Ki app 3.0 nM
CC(C)c1ccccc1Nc1nnc(SCc2ccco2)[nH]1 CHEMBL444369 Ki app 3.0 nM
c1cncc(Nc2nnc(SCc3ccncc3)[nH]2)c1 CHEMBL242272 Ki app 3.0 nM
N#Cc1cncc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c1 CHEMBL3798615 IC50 3.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccc(N4CCNCC4)nc3)cc2n1CC(F)(F)F CHEMBL3935543 IC50 3.06 nM
COc1ccc(Nc2nnc(SCC3CCCCC3)[nH]2)cc1 CHEMBL245007 Ki app 3.1 nM
Cc1ccc(Nc2nnc(SCc3ccc(F)c(F)c3)[nH]2)cc1 CHEMBL243321 Ki app 3.3 nM
Cc1ccccc1Nc1nnc(SCC2CCCCC2)[nH]1 CHEMBL245021 Ki app 3.3 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCC(F)CC3)cc2n1CC(F)(F)F CHEMBL3917406 IC50 3.45 nM
Cc1ccc(Nc2nnc(SCc3cc(C)on3)[nH]2)cc1 CHEMBL242461 pKi 3.467 nM
Cc1cc(CSc2nnc(Nc3ccccc3C)[nH]2)no1 CHEMBL243110 Ki app 3.6 nM
Cc1ccccc1Nc1nnc(SCc2ccncc2)[nH]1 CHEMBL398228 Ki app 3.7 nM
COC(=O)c1ccc(Nc2nnc(SCc3csc(C)n3)[nH]2)cc1 CHEMBL243102 Ki app 3.8 nM
Cc1nc(CSc2nnc(Nc3ccccc3C)[nH]2)cs1 CHEMBL395481 Ki app 3.8 nM
CN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3958170 IC50 3.87 nM
CN1CCN(c2ccc(-c3ccc4c5[nH]ncc5c(=O)n(CC(F)(F)F)c4c3)cc2)CC1 CHEMBL3944602 IC50 3.94 nM
Brc1cccc(-c2c[nH]nn2)c1 CHEMBL382312 Ki app 4.0 nM
COc1ccc(Nc2nnc(SCc3ccc(F)c(F)c3)[nH]2)cc1OC CHEMBL395028 Ki app 4.0 nM
Clc1ccc(Nc2nnc(SCc3ccccn3)[nH]2)cc1 CHEMBL397452 Ki app 4.0 nM
FC(F)(F)c1cc(-c2ccc3nccn3c2)c2cn[nH]c2c1 CHEMBL3798727 IC50 4.0 nM
O=C(NCCO)c1ccc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(F)c1 CHEMBL3798871 IC50 4.0 nM
CN1CCN(c2cc(-c3ccc4c5[nH]ncc5c(=O)n(CC(F)(F)F)c4c3)ccn2)CC1 CHEMBL3904411 IC50 4.12 nM
CCN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3941661 IC50 4.19 nM
Cc1ccc(-c2c[nH]nn2)cc1 CHEMBL193610 Ki 4.2 nM
CCC(=O)Nc1ccc(C)cc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3950368 IC50 4.29 nM
CN(CCO)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3945374 IC50 4.41 nM
CC(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3960287 IC50 4.68 nM
Cc1nc(CSc2nnc(Nc3ccc(Cl)cc3)[nH]2)cs1 CHEMBL242892 Ki app 4.8 nM
O=c1c2cn[nH]c2c2cc(Cl)c(-c3cccnc3Cl)cc2n1CC(F)(F)F CHEMBL3908559 IC50 4.9 nM
CN(C)CCS(=O)(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3979948 IC50 4.99 nM
COc1ccc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(OC)n1 CHEMBL3797286 IC50 5.0 nM
Cc1nc(N2CC[C@@H](O)C2)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3798702 IC50 5.0 nM
Cc1nc(N2CC[C@H](O)C2)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3799242 IC50 5.0 nM
Cc1nc(N2CC[C@@H](O)C2)ncc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3799512 IC50 5.0 nM
Cc1nc2[nH]cnc2cc1-n1c2ccc(F)cc2c2[nH]ncc21 CHEMBL3797399 pIC50 5.012 nM
Clc1ccc2c3[nH]ncc3n(-c3cccnc3)c2c1 CHEMBL3798249 pIC50 5.012 nM
Clc1ccc(Nc2nnc(SCC3CCCCC3)[nH]2)cc1 CHEMBL242679 Ki app 5.2 nM
Cc1ccc(Nc2nnc(SCc3cccs3)[nH]2)cc1 CHEMBL242673 Ki app 5.2 nM
CCN(CC)C/C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL208547 EC50 5.3 nM
CS(=O)(=O)Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3891524 IC50 5.33 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCCC3)cc2n1CC(F)(F)F CHEMBL3913956 IC50 5.34 nM
O=c1c2cn[nH]c2c2ccc(-c3ccnc(N4CCNCC4)c3)cc2n1CC(F)(F)F CHEMBL3934094 IC50 5.62 nM
c1ccc(CSc2nnc(Nc3cccnc3)[nH]2)nc1 CHEMBL242052 Ki app 5.7 nM
Cc1ccc(Nc2nnc(SCc3ccncc3)[nH]2)cc1 CHEMBL243322 Ki app 5.7 nM
O=C1NCCCC1N1Cc2cc(C3CCN(C(=O)CCCCCN4CCC(c5ccc(Oc6nn7cnnc7c7c6CCCC7)cc5)CC4)CC3)ccc2C1=O CHEMBL5465172 IC50 5.7 nM
Clc1ccc(-c2c[nH]nn2)cc1 CHEMBL196516 Ki app 6.0 nM
Cc1cccc(-c2c[nH]nn2)n1 CHEMBL371166 Ki app 6.0 nM
FC(F)(F)c1cc(-c2cncnc2)c2cn[nH]c2c1 CHEMBL3797663 IC50 6.0 nM
Cc1nc(N2CC[C@H](O)C2)ncc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3800596 IC50 6.0 nM
CN1CCCN(c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 CHEMBL3901247 IC50 6.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCCNCC3)cc2n1CC(F)(F)F CHEMBL3925571 IC50 6.08 nM
COc1ccc(Nc2nnc(SCc3ccncc3)[nH]2)cc1 CHEMBL394570 Ki app 6.1 nM
Cc1cc(C(=O)NCCO)ccc1-n1c2ccc(F)cc2c2[nH]ncc21 CHEMBL3799090 pIC50 6.31 nM
O=C(NCCO)c1ccc(-n2c3ccc(F)cc3c3[nH]ncc32)cc1 CHEMBL3797259 pIC50 6.31 nM
O=c1c2c[nH]nc2c2ccc(-c3cccnc3N3CC(O)C(O)C3)cc2n1CC(F)(F)F CHEMBL3895483 IC50 6.41 nM
c1cncc(Nc2nnc(SCC3CCCCC3)[nH]2)c1 CHEMBL395715 Ki app 6.5 nM
Cc1ccc(Nc2nnc(SCc3ccccc3C)[nH]2)cc1 CHEMBL243112 Ki app 6.5 nM
CO[C@@H]1[C@H](OC(=O)N[C@@H](C(N)=O)C(C)C)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@@H]1OC1(C)C CHEMBL3527328 EC50 6.5 nM
COc1ccc(Nc2nnc(SCc3cc(C)on3)[nH]2)cc1OC CHEMBL242662 Ki app 7.0 nM
Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3901734 IC50 7.06 nM
CO[C@@H]1[C@H](OC(=O)N[C@@H](C(N)=O)C(C)C)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C/C=C(\C)CO CHEMBL3527383 EC50 7.1 nM
O=c1c2cn[nH]c2c2cc(F)c(-c3ccccn3)cc2n1CC(F)(F)F CHEMBL3928567 IC50 7.1 nM
CN1CCN(c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 CHEMBL3930411 IC50 7.24 nM
Cc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3943061 IC50 7.38 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3Cl)cc2n1CC(F)(F)F CHEMBL3923146 IC50 7.42 nM
O=c1c2cn[nH]c2c2ccc(-c3ccccn3)cc2n1CC(F)(F)F CHEMBL3972816 IC50 7.53 nM
Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3957907 IC50 7.64 nM
Cc1ccc(Nc2nnc(SCc3ccccn3)[nH]2)cc1 CHEMBL437011 pKi 7.762 nM
Cc1ccc(Nc2nnc(SCc3csc(C)n3)[nH]2)cc1 CHEMBL242024 pKi 7.762 nM
O=c1c2cn[nH]c2c2cc(Cl)c(-c3ccncc3)cc2n1CC(F)(F)F CHEMBL3938818 IC50 7.77 nM
Nc1ncc(-n2c3ccc(F)cc3c3[nH]ncc32)cc1Cl CHEMBL3800236 pIC50 7.943 nM
Fc1cc2c3[nH]ncc3n(-c3cccnc3)c2cc1F CHEMBL3798844 pIC50 7.943 nM
Cc1ccnc(-c2c[nH]nn2)c1 CHEMBL194799 Ki app 8.0 nM
COc1c(-c2ccoc2)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(=O)O CHEMBL388245 IC50 8.0 nM
COc1cnccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3799449 IC50 8.0 nM
Fc1cnccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3800546 IC50 8.0 nM
COc1ncc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(OC)n1 CHEMBL3800534 IC50 8.0 nM
O=c1c2cn[nH]c2c2cc(Cl)c(-c3ccccn3)cc2n1CC(F)(F)F CHEMBL3929804 IC50 8.22 nM
COc1ccc(Nc2nnc(SCC3CCCCC3)[nH]2)cc1OC CHEMBL242232 Ki app 8.3 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCCOCC3)cc2n1CC(F)(F)F CHEMBL3946517 IC50 8.35 nM
CO[C@@H]1[C@H](OC(=O)N[C@@H](C(N)=O)C(C)(C)O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@H]1OC1(C)C CHEMBL3527218 EC50 8.8 nM
Cc1cc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)cc(C)n1 CHEMBL3984809 IC50 8.81 nM
O=c1c2cn[nH]c2c2ccc(-c3ncccc3Cl)cc2n1CC(F)(F)F CHEMBL3952819 IC50 8.83 nM
CO[C@@H]1[C@H](OC(C)=O)CC[C@]2(CO2)[C@H]1/C(C)=C/CC=C(C)C CHEMBL172948 IC50 8.9 nM
CN1CCCN(C(=O)c2ccccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 CHEMBL3919632 IC50 8.98 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2)ccc2c1CCCC2 CHEMBL380394 IC50 9.0 nM
CCN(CC)CCCc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209686 IC50 9.0 nM
CCN(C)C/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL438433 IC50 9.0 nM
Cc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)O)cc1 CHEMBL2407597 IC50 9.0 nM
Cn1nccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3799467 IC50 9.0 nM
O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2cnc3[nH]cc(Cl)c3c2)C1=O CHEMBL4572028 IC50 9.0 nM
CC(=O)Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3901263 IC50 9.01 nM
Cc1nc(CSc2nnc(Nc3cccnc3)[nH]2)cs1 CHEMBL242000 Ki app 9.1 nM
O=c1c2cn[nH]c2c2ccc(-c3ccccc3CN3CCCNCC3)cc2n1CC(F)(F)F CHEMBL3908228 IC50 9.22 nM
COC(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3976726 IC50 9.36 nM
O=C1CN(c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CCN1 CHEMBL3975808 IC50 9.44 nM
CN(C)CCN(C)C(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3907107 IC50 9.53 nM
COc1ccc(Nc2nnc(SCc3ccncc3)[nH]2)cc1OC CHEMBL242230 Ki app 9.6 nM
CS(=O)(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3924037 IC50 9.66 nM
O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2)ccc2c1CCCC2 CHEMBL379124 IC50 10.0 nM
CN(C)CCCc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL378993 IC50 10.0 nM
CC(/C=C\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2)N1CCCC1 CHEMBL376940 IC50 10.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCn2ccnc2)ccc2c1CCCC2 CHEMBL209206 IC50 10.0 nM
CCc1ccc(NS(=O)(=O)c2ccccc2NCCCCN(C)C)c(C(=O)O)c1OC CHEMBL230407 IC50 10.0 nM
COC(=O)c1ccc(Nc2nnc(SCc3ccccc3OC)[nH]2)cc1 CHEMBL242874 Ki app 10.0 nM
Cc1nc2c(cc1-n1c3ccc(F)cc3c3[nH]ncc31)ncn2C CHEMBL3799796 pIC50 10.0 nM
Cc1c(-n2c3ccc(F)cc3c3[nH]ncc32)cnc2[nH]cnc12 CHEMBL3797780 pIC50 10.0 nM
COc1nc(N)ncc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3797707 IC50 10.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3NS(=O)(=O)Cc3ccccc3)cc2n1CC(F)(F)F CHEMBL3945936 IC50 10.2 nM
Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3913665 IC50 10.4 nM
CNc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3985583 IC50 10.6 nM
CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1OC CHEMBL230280 IC50 11.0 nM
Cc1cnccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3798034 IC50 11.0 nM
Cc1cc(C(=O)NCCO)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3800090 IC50 11.0 nM
Cc1cc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2cc1-c1cccnc1Cl CHEMBL3927634 IC50 11.1 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3O)cc2n1CC(F)(F)F CHEMBL3978845 IC50 11.3 nM
CO[C@@H]1[C@H](OC(=O)N[C@@H](C(N)=O)C(C)(C)O)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@@H]1OC1(C)C CHEMBL3527219 EC50 11.7 nM
COCC(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3930908 IC50 11.8 nM
CC(C)N(C)C/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211548 IC50 12.0 nM
CCN(CC)C/C=C\c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL2096830 IC50 12.0 nM
CN(C)CCCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL380218 IC50 12.0 nM
O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2ccc3[nH]ccc3c2)C1=O CHEMBL4463138 IC50 12.0 nM
CCNCCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211544 pIC50 12.02 nM
O=C(c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)N1CCOCC1 CHEMBL3896253 IC50 12.1 nM
Cc1ccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)c(Cl)n1 CHEMBL3933046 IC50 12.3 nM
CN(C)C(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3978127 IC50 12.5 nM
Fc1ccc2c(c1)c1[nH]ncc1n2-c1cccnc1 CHEMBL3797386 pIC50 12.59 nM
NCCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL212257 pIC50 12.88 nM
Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL377888 pIC50 12.88 nM
O=C(NCCc1ccncc1)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3902138 IC50 12.9 nM
c1ccc2oc(-c3c[nH]nn3)cc2c1 CHEMBL443486 Ki app 13.0 nM
COc1cc(C(=O)NCCO)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3798047 IC50 13.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCC3)cc2n1CC(F)(F)F CHEMBL3930974 IC50 13.0 nM
O=C(NCc1cc(F)cc(F)c1)[C@@]1(O)CCN(c2cnc3[nH]cc(Cl)c3c2)C1=O CHEMBL4591797 IC50 13.0 nM
CN(C)CCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL380267 IC50 14.0 nM
Cc1cc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc2[nH]1 CHEMBL4553094 IC50 14.0 nM
CCNC(=O)c1cc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc2[nH]1 CHEMBL4445117 IC50 14.0 nM
O=C(c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)N1CCOCC1 CHEMBL3980759 IC50 14.1 nM
CN(C)CCN(C)C(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3969775 IC50 14.5 nM
O=C(c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)N1CCCOCC1 CHEMBL3893168 IC50 14.7 nM
O=c1c2cn[nH]c2c2ccc(-c3ccnc(Cl)c3)cc2n1CC(F)(F)F CHEMBL3957068 IC50 14.9 nM
O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2)ccc2ccccc12 CHEMBL212006 IC50 15.0 nM
CN(C/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2)CCO CHEMBL211271 IC50 15.0 nM
CCN(C/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2)CCO CHEMBL377555 IC50 15.0 nM
CN1CCC(CNc2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC1 CHEMBL210557 IC50 15.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCNCCO)ccc2c1CCCC2 CHEMBL377526 IC50 15.0 nM
CCN(CC)C/C=C\c1cc(F)ccc1S(=O)(=O)Nc1ccc(-c2ccoc2)c(OC)c1C(=O)O CHEMBL230838 IC50 15.0 nM
CCc1ccc(NS(=O)(=O)c2ccccc2NCCC2CCCN2C)c(C(=O)O)c1OC CHEMBL388898 IC50 15.0 nM
CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1Cl CHEMBL230386 IC50 15.0 nM
CN(c1ccccc1)c1nnc(SCc2ccccc2)[nH]1 CHEMBL230540 Ki app 15.0 nM
CNC(=O)c1ccc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(OC)c1 CHEMBL3798381 IC50 15.0 nM
CCN(CC)CCCNc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209074 pIC50 15.14 nM
O=C(Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)C1CC1 CHEMBL3938830 IC50 15.3 nM
O=c1c2c[nH]nc2c2cc(Br)c(-c3ccncc3)cc2n1CC(F)(F)F CHEMBL3907315 IC50 15.6 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCc2ccncc2)ccc2c1CCCC2 CHEMBL208913 pIC50 15.85 nM
Ic1cccc(-c2c[nH]nn2)c1 CHEMBL380817 Ki app 16.0 nM
CCN(CC)C(C)/C=C\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210085 IC50 16.0 nM
CCN(CC)CC/C=C\c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL2096831 IC50 16.0 nM
CCCc1ccccc1S(=O)(=O)Nc1ccc(CC)c(OCCN)c1C(=O)O CHEMBL389807 IC50 16.0 nM
CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1C CHEMBL230172 IC50 16.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4F)C3=O)ccc2N1 CHEMBL4550096 IC50 16.0 nM
CC(C)NCc1ccc(-c2ccccc2-c2ccc3c4n[nH]cc4c(=O)n(CC(F)(F)F)c3c2)o1 CHEMBL3935645 IC50 16.9 nM
CC(=O)N1CCCN(c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 CHEMBL3961266 IC50 16.9 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCCC2)ccc2c1CCCC2 CHEMBL1184942 pIC50 16.98 nM
CN1CCCC1CCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209330 pIC50 16.98 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCC2CCNCC2)ccc2c1CCCC2 CHEMBL211660 pIC50 16.98 nM
CCN(CC)CCCc1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211148 IC50 17.0 nM
CCN(CC)C/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210877 IC50 17.0 nM
CCN(CC)CCNC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211435 IC50 17.0 nM
COc1c(-c2ccoc2)ccc(NS(=O)(=O)c2ccc(F)cc2NCCCN(C)C)c1C(=O)O CHEMBL230729 IC50 17.0 nM
Cc1cccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)n1 CHEMBL3947459 IC50 17.3 nM
O=c1c2cn[nH]c2c2ccc(-c3ccccc3CN3CCOCC3)cc2n1CC(F)(F)F CHEMBL3916484 IC50 17.4 nM
N#Cc1cc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2cc1-c1ccncc1 CHEMBL3952165 IC50 17.9 nM
Cc1cccc(-c2c[nH]nn2)c1 CHEMBL194853 Ki app 18.0 nM
CN(C)CC(C)(C)CNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209942 IC50 18.0 nM
CCc1ccc(NS(=O)(=O)c2ccccc2NCCCN2CCCCC2C)c(C(=O)O)c1OC CHEMBL439225 IC50 18.0 nM
COc1ccc(Nc2nnc(SCc3ccccc3C)[nH]2)cc1OC CHEMBL243745 Ki app 18.0 nM
COc1ccc(Nc2nnc(SCc3ccccn3)[nH]2)cc1 CHEMBL388923 Ki app 18.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccc[n+]3[O-])cc2n1CC(F)(F)F CHEMBL3908456 IC50 18.0 nM
CN(C)CCCNC(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3907599 IC50 18.3 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2)ccc2ccccc12 CHEMBL377198 IC50 19.0 nM
CN(C)C/C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL1162929 IC50 19.0 nM
CCN(CC)C(C)/C=C\c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209012 IC50 19.0 nM
CCN(CC)CCCNc1cccc(F)c1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL208946 IC50 19.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3F)cc2n1CC(F)(F)F CHEMBL3939724 IC50 19.2 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCCCC2)ccc2c1CCCC2 CHEMBL379518 pIC50 19.95 nM
C[C@H](NC(=O)[C@@H](O)[C@H](N)CCc1ccccc1)c1cccc2ccccc12 CHEMBL168365 IC50 20.0 nM
CCSCC[C@@H](N)[C@H](O)C(=O)N(C)Cc1cccc2ccccc12 CHEMBL168717 IC50 20.0 nM
CC1=CCCc2ccc(NS(=O)(=O)c3ccc(F)cc3)c(C(=O)O)c21 CHEMBL212638 IC50 20.0 nM
CCN(CC)CCC/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL212011 IC50 20.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2/C=C\CN2CCCC2)ccc2c1CCCC2 CHEMBL377912 IC50 20.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2/C=C\CN2CCCC2)ccc2c1CCCC2 CHEMBL378982 IC50 20.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NC2CCN(Cc3ccccc3)CC2)ccc2c1CCCC2 CHEMBL379841 IC50 20.0 nM
COc1c(-c2ccoc2)ccc(NS(=O)(=O)c2ccc(F)cc2Br)c1C(=O)O CHEMBL425829 IC50 20.0 nM
FC(F)(F)c1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3798509 IC50 20.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(CN)cc3)cc21 CHEMBL3927822 IC50 20.0 nM
CCCNCc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3945607 IC50 20.3 nM
COc1ccc(Nc2nnc(SCc3csc(C)n3)[nH]2)cc1OC CHEMBL242449 Ki app 21.0 nM
Cc1cc(C(=O)NCCO)ncc1-c1cc(C(F)(F)F)cc2[nH]ncc12 CHEMBL3797699 IC50 21.0 nM
Cc1nc(Cl)ccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3913543 IC50 21.4 nM
CNC(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3962187 IC50 21.7 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCOCC2)ccc2c1CCCC2 CHEMBL212733 pIC50 21.88 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCC2CCCN2)ccc2c1CCCC2 CHEMBL211711 pIC50 21.88 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3)cc2n1CC(F)(F)F CHEMBL3985184 IC50 21.9 nM
O=c1c2cn[nH]c2c2cc(Br)c(-c3ccccn3)cc2n1CC(F)(F)F CHEMBL3901853 IC50 22.4 nM
O=C(Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)C1CC1 CHEMBL3937180 IC50 22.5 nM
COc1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3983359 IC50 22.7 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(N4CCNCC4)nc3)cc21 CHEMBL3928887 IC50 22.9 nM
CCN(CC)CC[S+]([O-])c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211121 EC50 23.0 nM
Cc1ccccc1CSc1nnc(Nc2ccc(Cl)cc2)[nH]1 CHEMBL242248 Ki app 23.0 nM
Cc1cc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2cc1-c1ccccn1 CHEMBL3952991 IC50 23.3 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccc(OC)c3O)cc21 CHEMBL3931130 IC50 23.9 nM
O=c1c2cn[nH]c2c2ccc(-c3cncnc3C3CCCC3)cc2n1CC(F)(F)F CHEMBL3946319 IC50 23.9 nM
CCc1ccc(NS(=O)(=O)c2ccc(F)cc2CCCN(CC)CC)c(C(=O)O)c1OCCN CHEMBL230406 IC50 24.0 nM
CC(C)c1ccccc1Nc1nnc(SCc2ccoc2)[nH]1 CHEMBL230005 Ki app 24.0 nM
COc1ccc(Nc2nnc(SCc3ccccn3)[nH]2)cc1OC CHEMBL242446 Ki app 24.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCOCC3)cc2n1CC(F)(F)F CHEMBL3901463 IC50 24.0 nM
COCCN(C)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3955079 IC50 24.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccnc(N4CCN(C)CC4)c3)cc21 CHEMBL3906098 IC50 24.1 nM
CC(=O)N(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3944335 IC50 24.2 nM
O=c1c2c[nH]nc2c2ccc(-c3cccnc3N3CCCN(C4CC4)CC3)cc2n1CC(F)(F)F CHEMBL3972375 IC50 24.3 nM
CO[C@@H]1[C@H](OC(C)=O)CC[C@]2(CO2)[C@H]1/C(C)=N\OCc1ccccc1 CHEMBL2110259 IC50 25.0 nM
CCN(CC)CC/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL377128 IC50 25.0 nM
CCN(CC)CCCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210499 IC50 25.0 nM
CCN(CC)CCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211080 IC50 25.0 nM
Cc1cc(Cl)ncc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3890963 IC50 25.1 nM
CC(C)C(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3922654 IC50 25.4 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCN(CCO)CCO)ccc2c1CCCC2 CHEMBL211277 pIC50 25.7 nM
CN1CCN(CCCNc2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC1 CHEMBL211763 pIC50 25.7 nM
CCc1ccc(NS(=O)(=O)c2ccc(F)cc2/C=C\CN(CC)CC)c(C(=O)O)c1OC CHEMBL230728 IC50 26.0 nM
O=c1c2c[nH]nc2c2ccc(-c3ccc(-c4nn[nH]n4)cc3)cc2n1CC(F)(F)F CHEMBL3952975 IC50 26.3 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3C(F)(F)F)cc2n1CC(F)(F)F CHEMBL3975741 IC50 26.8 nM
C[C@H]1CCCc2ccc(NS(=O)(=O)c3ccc(F)cc3)c(C(=O)O)c21 CHEMBL210037 IC50 27.0 nM
CN(C)C/C=C/c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL1162930 IC50 27.0 nM
O=C(NCc1cccnc1)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3924324 IC50 27.8 nM
CCN(CC)CCC/C=C\c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL2096832 IC50 28.0 nM
CC(=O)N1CCN(c2ncccc2-c2ccc3c4n[nH]cc4c(=O)n(CC(F)(F)F)c3c2)CC1 CHEMBL3932166 IC50 28.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccc(N4CCOCC4)nc3)cc2n1CC(F)(F)F CHEMBL3927933 IC50 28.9 nM
c1ccc(CNc2cccc(-c3c[nH]nn3)c2)cc1 CHEMBL382292 Ki app 29.0 nM
CCN(Cc1ccncc1)C(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3899817 IC50 29.6 nM
CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 CHEMBL352943 IC50 30.0 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1 CHEMBL171731 IC50 30.0 nM
CCc1ccc(-c2c[nH]nn2)cc1 CHEMBL194423 Ki app 30.0 nM
CC(/C=C\c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2)N1CCCC1 CHEMBL212362 IC50 30.0 nM
CN(C)CCSc1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL377965 IC50 30.0 nM
O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2ccc3[nH]ncc3c2)C1=O CHEMBL4460444 IC50 30.0 nM
CCOC(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3957948 IC50 30.4 nM
O=c1c2c[nH]nc2c2ccc(-c3ccccc3N3CCNCC3)cc2n1CC(F)(F)F CHEMBL3931045 IC50 30.5 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(OCCCN(C)C)nc3)cc21 CHEMBL3899944 IC50 30.7 nM
CCN(CC)CCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211607 pIC50 30.9 nM
CC(C)N(CCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2)C(C)C CHEMBL377409 pIC50 30.9 nM
CCN(CC)CCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211070 IC50 31.0 nM
CCN(CC)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3959680 IC50 31.1 nM
Cc1ccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)c(OC2CCNCC2)c1 CHEMBL3931456 IC50 31.3 nM
O=C(CCCN1CCCCC1)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210559 IC50 32.0 nM
CN(C)CCCC(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3931827 IC50 32.9 nM
CCSCC[C@@H](N)[C@H](O)C(=O)Nc1ccc(NC(=O)/C=C/c2ccc(OC)cc2)cc1 CHEMBL110289 IC50 33.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3NC3CC3)cc2n1CC(F)(F)F CHEMBL3892510 IC50 33.3 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCC2CCNC2)ccc2c1CCCC2 CHEMBL378724 pIC50 33.88 nM
COc1ccc(Nc2nnc(SCc3ccccc3OC)[nH]2)cc1 CHEMBL242490 Ki app 34.0 nM
O=c1c2c[nH]nc2c2ccc(-c3cccnc3N3CCC(F)C3)cc2n1CC(F)(F)F CHEMBL3983702 IC50 34.0 nM
NCCCNC(=O)c1cc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc2[nH]1 CHEMBL4454587 IC50 34.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3NC3CCC3)cc2n1CC(F)(F)F CHEMBL3986627 IC50 34.5 nM
CC1CN(c2ncccc2-c2ccc3c4n[nH]cc4c(=O)n(CC(F)(F)F)c3c2)CC(C)O1 CHEMBL3970727 IC50 34.5 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCC2CCCNC2)ccc2c1CCCC2 CHEMBL209277 pIC50 34.67 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCc2ccncc2)ccc2c1CCCC2 CHEMBL210958 pIC50 34.67 nM
CCSCC[C@@H](N)[C@H](O)C(=O)Nc1ccc(NC(=O)/C=C/c2ccccc2)cc1 CHEMBL110321 IC50 35.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cncnc3C3CCCCC3)cc2n1CC(F)(F)F CHEMBL3972291 IC50 35.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccc4cccnc34)cc21 CHEMBL3908851 IC50 35.7 nM
NC(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3922556 IC50 36.2 nM
CCN(CCN(C)C)C(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3891580 IC50 36.4 nM
CN1CCCC1CCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210357 IC50 37.0 nM
CCN(CC)CCSc1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209371 IC50 37.0 nM
CCN(CC)CC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211155 IC50 38.0 nM
CCOc1c(CC)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(=O)O CHEMBL230491 IC50 38.0 nM
c1ccc2c(OC[C@H]3CCCN3c3ccnc4ncnn34)cncc2c1 CHEMBL4060668 IC50 38.0 nM
CCN(CC)CC[S+]([O-])c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL378631 IC50 39.0 nM
CN(C)c1ccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)cc1 CHEMBL3968760 IC50 39.4 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCCC2=O)ccc2c1CCCC2 CHEMBL211788 pIC50 39.81 nM
CCCSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 CHEMBL434491 IC50 40.0 nM
Cn1ccnc1C(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3958676 IC50 40.1 nM
CN(C)CCC(=O)Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3980674 IC50 40.6 nM
c1ccc(-c2c[nH]nn2)nc1 CHEMBL196660 Ki app 41.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccc(N4CCOCC4)cc3)cc2n1CC(F)(F)F CHEMBL3985472 IC50 41.1 nM
O=c1c2c[nH]nc2c2ccc(-c3cccc(Cl)n3)cc2n1CC(F)(F)F CHEMBL3982290 IC50 41.7 nM
O=C(NCCCN1CCCCC1)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209721 IC50 42.0 nM
O=C(CCCN1CCCC1)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL377854 IC50 42.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ncccc3C(F)(F)F)cc2n1CC(F)(F)F CHEMBL3961504 IC50 42.8 nM
CCSCC[C@@H](N)[C@H](O)C(=O)Nc1ccc(NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 CHEMBL109136 IC50 43.0 nM
CCN(CC)CCCSc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209264 IC50 43.0 nM
O=c1c2c[nH]nc2c2ccc(-c3cccnc3N3CCN(C4CC4)CC3)cc2n1CC(F)(F)F CHEMBL3978405 IC50 43.0 nM
CCN(CC)CCCCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210500 IC50 44.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(F)c4F)C3=O)ccc2N1 CHEMBL4551283 IC50 44.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccc3NS(C)(=O)=O)cc21 CHEMBL3939131 IC50 44.5 nM
CCSCC[C@@H](N)[C@H](O)C(=O)Nc1ccc(NC(=O)c2ccc(OC)cc2)cc1 CHEMBL110539 IC50 45.0 nM
CCN(CC)CCCCCc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211233 IC50 45.0 nM
CC(C)N1CCC(CNc2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC1 CHEMBL212407 pIC50 45.71 nM
CCOc1ccc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CCSCC)cc2)cc1 CHEMBL322528 IC50 46.0 nM
CCN(CC)CCSc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL212461 IC50 46.0 nM
CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1OCCN CHEMBL230492 IC50 46.0 nM
CS(=O)(=O)Nc1cccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)c1 CHEMBL4448427 IC50 46.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccc(C(=O)NCCCN(C)C)c3)cc21 CHEMBL3966570 IC50 46.4 nM
CN(C)CCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211687 pIC50 47.86 nM
Cc1ccc(NNC(=O)[C@@H](O)[C@H](N)CCSC(C)C)cc1 CHEMBL172616 IC50 50.0 nM
CCSCC[C@@H](N)[C@H](O)C(=O)NNc1ccc(C)cc1 CHEMBL168757 IC50 50.0 nM
CCSCC[C@@H](N)[C@H](O)C(=O)NNc1cccc2ccccc12 CHEMBL355427 IC50 50.0 nM
CC(C)SCC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1 CHEMBL167482 IC50 50.0 nM
CCCSC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1 CHEMBL171142 IC50 50.0 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 CHEMBL171479 IC50 50.0 nM
CCSCC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1 CHEMBL166955 IC50 50.0 nM
O=C(NCCN1CCCCC1)c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210358 IC50 50.0 nM
O=C(NCCc1cccs1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4566670 IC50 50.0 nM
O=C1Cc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc2N1 CHEMBL4524329 IC50 50.0 nM
FC(F)(F)c1ccc2cn[nH]c2c1 CHEMBL3797508 pIC50 50.12 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc4ncccc4c3)cc21 CHEMBL3921304 IC50 50.4 nM
CCN(CC)CCOC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209722 IC50 51.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccc(Cl)nc3)cc2n1CC(F)(F)F CHEMBL3893310 IC50 51.0 nM
N#Cc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3977857 IC50 51.9 nM
c1ccc2c(c1)Cc1n[nH]nc1-2 CHEMBL372362 Ki app 52.0 nM
Cc1cccnc1-c1c[nH]nn1 CHEMBL371119 Ki app 52.0 nM
CN(C)CCSc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209619 IC50 52.0 nM
CCCCN(CCCC)CCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211859 IC50 52.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(F)c4)C3=O)ccc2N1 CHEMBL4460950 IC50 52.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cccc(F)c4F)C3=O)ccc2N1 CHEMBL4522216 IC50 52.0 nM
CCCN(CCC)CCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL1254633 pIC50 52.48 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCc2ccccn2)ccc2c1CCCC2 CHEMBL210895 pIC50 52.48 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccnc(N4CCNCC4)c3)cc21 CHEMBL3911663 IC50 52.5 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cccc(Cl)c4F)C3=O)ccc2N1 CHEMBL4547442 IC50 53.0 nM
CN(C)CC[S+]([O-])c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL380194 IC50 54.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccc(OC)c3F)cc21 CHEMBL3950144 IC50 54.9 nM
CN1CCC(N2CCC(CNc3ccccc3S(=O)(=O)Nc3ccc4c(c3C(=O)O)CCCC4)CC2)CC1 CHEMBL378561 pIC50 54.95 nM
CN(C)CC1CC1c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL212745 IC50 55.0 nM
CCN(CC)CC1CC1c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL379782 IC50 55.0 nM
O=C(NCCCN1CCOCC1)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL379170 IC50 55.0 nM
CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1 CHEMBL389806 IC50 55.0 nM
O=[N+]([O-])c1ccc(O)c2ncccc12 CHEMBL1454910 IC50 55.0 nM
Oc1ccc(Cl)c2cccnc12 CHEMBL225164 IC50 55.0 nM
COC(C(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)c1ccccc1 CHEMBL3940422 IC50 55.1 nM
CCSCC[C@@H](N)[C@H](O)C(=O)Nc1ccc(NC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1 CHEMBL108515 IC50 56.0 nM
CCN(CC)CCCNc1ccc(Cl)cc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL376985 IC50 56.0 nM
CC(C(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)c1ccccc1 CHEMBL3973373 IC50 56.4 nM
CC(C)NC(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3907002 IC50 56.8 nM
CO[C@@H]1[C@H](OC(N)=O)CC[C@]2(CO2)[C@H]1/C(C)=N\OCc1ccccc1 CHEMBL2110260 IC50 57.0 nM
O=C(NCCc1cccs1)C1(O)CCN(c2ccccc2)C1=O CHEMBL4438796 IC50 57.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCC(N3CCCCC3)CC2)ccc2c1CCCC2 CHEMBL379479 pIC50 57.54 nM
CCSCC[C@@H](N)[C@H](O)C(=O)Nc1ccccc1 CHEMBL110540 IC50 58.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(C)nc3Cl)cc21 CHEMBL3948394 IC50 58.7 nM
CCN(CC)CCCC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209207 IC50 59.0 nM
CCN(CC)CCC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL208608 IC50 59.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(F)cc3O)cc21 CHEMBL3940368 IC50 59.6 nM
Cc1ccc(NNC(=O)[C@@H](O)[C@H](N)CSCC(C)C)cc1 CHEMBL168267 IC50 60.0 nM
C=Cc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1C CHEMBL387585 IC50 60.0 nM
O=C(NCc1cc(Cl)cc(Cl)c1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4462995 IC50 60.0 nM
O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4552396 IC50 60.0 nM
NC(=O)c1cccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)c1 CHEMBL4460784 IC50 60.0 nM
NC(=O)c1ccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)cc1 CHEMBL4536649 IC50 60.0 nM
CNc1ccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)cc1 CHEMBL3949039 IC50 60.6 nM
COc1ccccc1CSc1nnc(Nc2ccccc2C)[nH]1 CHEMBL396469 Ki app 61.0 nM
N#Cc1cccnc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3945238 IC50 61.2 nM
CC(C)N1CCCC1CCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL387176 pIC50 61.66 nM
O=c1c2c[nH]nc2c2ccc(Oc3cccnc3)cc2n1CC(F)(F)F CHEMBL3971178 IC50 61.9 nM
CN(C)CC[S+]([O-])c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL377424 IC50 62.0 nM
N#Cc1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3798100 IC50 62.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4c(F)ccc(F)c4F)C3=O)ccc2N1 CHEMBL4570368 IC50 62.0 nM
COC(=O)c1cccnc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3959076 IC50 62.2 nM
CCCOc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3984309 IC50 63.8 nM
O=c1c2cn[nH]c2c2ccc(-c3cc[n+]([O-])cc3)cc2n1CC(F)(F)F CHEMBL3977788 IC50 65.7 nM
CCN(CC)CCCNc1ccc(C)cc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL212326 IC50 66.0 nM
CC(C)CCSc1nnc(Nc2ccccc2)[nH]1 CHEMBL396975 Ki app 66.0 nM
Cc1cc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)cnc1Cl CHEMBL3979798 IC50 66.9 nM
COc1cc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CCc3ccccc3)cc2)cc(OC)c1OC CHEMBL110292 IC50 67.0 nM
CCN(CC)CCCC(C)NC(=O)c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210610 IC50 67.0 nM
CCc1ccc(NS(=O)(=O)c2ccccn2)c(C(=O)O)c1C CHEMBL230494 IC50 67.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCC2CCCN2C2CCCCC2)ccc2c1CCCC2 CHEMBL211127 IC50 69.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCN2CCCC2)ccc2c1CCCC2 CHEMBL209211 IC50 69.0 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1ccc2ccccc2c1 CHEMBL172153 IC50 70.0 nM
c1ccc(-c2cnn[nH]2)cc1 CHEMBL193664 Ki app 70.0 nM
CN1CCC(N2CCCC2CCNc2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC1 CHEMBL377811 IC50 70.0 nM
O=c1c2c[nH]nc2c2ccc(-c3ccnc(N4CCN(C5CC5)CC4)c3)cc2n1CC(F)(F)F CHEMBL3954060 IC50 70.9 nM
CCN(CCN(C)C)C(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3942788 IC50 71.4 nM
CN1CCCC1CCNC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL211997 IC50 72.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ncc(Cl)cc3Cl)cc2n1CC(F)(F)F CHEMBL3928738 IC50 72.0 nM
O=C(NCc1cc(F)cc(F)c1)[C@@]1(O)CCN(c2ccc3[nH]ncc3c2)C1=O CHEMBL4450159 IC50 72.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ncccc3O)cc2n1CC(F)(F)F CHEMBL3946967 IC50 74.6 nM
CN(C(=O)C1CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3952958 IC50 75.2 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3NS(=O)(=O)c3cccc(Cl)c3)cc2n1CC(F)(F)F CHEMBL3890996 IC50 76.3 nM
CC(C)(C)OC(=O)NCCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL212380 IC50 77.0 nM
Cc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1C CHEMBL230171 IC50 78.0 nM
Clc1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3799496 IC50 79.0 nM
CN1C(=O)CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc21 CHEMBL4458906 IC50 79.0 nM
Fc1ccc2[nH]c3cn[nH]c3c2c1 CHEMBL3797789 pIC50 79.43 nM
O=C(NCc1cc(F)cc(F)c1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4558399 IC50 80.0 nM
CC(=O)Nc1cccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)c1 CHEMBL4464652 IC50 80.0 nM
CC(=O)Nc1ccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)cc1 CHEMBL4466601 IC50 80.0 nM
COc1cc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CCc3ccccc3)c(C)c2)cc(OC)c1OC CHEMBL108398 IC50 82.0 nM
O=C(NCCN1CCCCC1)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209781 IC50 82.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCCCC3)cc2n1CC(F)(F)F CHEMBL3952372 IC50 82.8 nM
O=c1c2cn[nH]c2c2ccc(-c3ccccc3N3CCOCC3)cc2n1CC(F)(F)F CHEMBL3943574 IC50 83.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3)cc2n1C1CC1 CHEMBL3897064 IC50 83.1 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccnc3F)cc21 CHEMBL3969275 IC50 83.5 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccnc3C)cc21 CHEMBL3920593 IC50 84.3 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccc3O)cc21 CHEMBL3917599 IC50 84.4 nM
COc1ccc(CNC(C)=O)cc1S(=O)(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3918690 IC50 85.0 nM
O=c1c2c[nH]nc2c2ccc(-c3cccnc3NC3CCCCC3)cc2n1CC(F)(F)F CHEMBL3958647 IC50 85.7 nM
CC(C)N(C)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3893489 IC50 86.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccncc3F)cc21 CHEMBL3913058 IC50 87.0 nM
CN(C)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3923117 IC50 87.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccncc3Cl)cc21 CHEMBL3974955 IC50 88.6 nM
CCc1ccc(NS(=O)(=O)c2ccccc2)c(C(=O)O)c1 CHEMBL377012 IC50 90.0 nM
Cc1cccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)c1 CHEMBL4546986 IC50 90.0 nM
Cc1ccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)cc1 CHEMBL4465025 IC50 90.0 nM
N#Cc1cccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)c1 CHEMBL4469817 IC50 90.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccc3NC(C)=O)cc21 CHEMBL3982986 IC50 90.3 nM
CN1C(C)(C)CC(Nc2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC1(C)C CHEMBL211453 IC50 91.0 nM
FC(F)(F)Oc1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3798443 IC50 91.0 nM
CC1(C)CC(Nc2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC(C)(C)N1 CHEMBL1253792 pIC50 91.2 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4c(F)cccc4F)C3=O)ccc2N1 CHEMBL4566917 IC50 94.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)cc(F)c2N1 CHEMBL4441643 IC50 95.0 nM
COc1cc(/C=C/C(=O)NC2CCC(NC(=O)[C@@H](O)[C@H](N)CCc3ccccc3)CC2)cc(OC)c1OC CHEMBL110703 IC50 98.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccnc3OC)cc21 CHEMBL3922536 IC50 99.9 nM
CCOC(=O)[C@@H](C)NC(=O)C(O)[C@H](N)CCSCC CHEMBL323200 IC50 100.0 nM
Cc1ccc(Nc2nnc(SCC3CCCCC3)[nH]2)cc1 CHEMBL243323 Ki app 100.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)cc21 CHEMBL3945492 IC50 102.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccnc3Nc3ccc(F)cc3)cc2n1CC(F)(F)F CHEMBL3915585 IC50 102.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cnc(F)c(C)c3)cc21 CHEMBL3904059 IC50 106.0 nM
O=c1c2c[nH]nc2c2ccc(-c3cccnc3NC3CCCC3)cc2n1CC(F)(F)F CHEMBL3962500 IC50 106.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3)cc2n1CC(F)F CHEMBL3953133 IC50 109.0 nM
CN(CCCNc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2)C(=O)OC(C)(C)C CHEMBL377445 pIC50 109.65 nM
CCN(CC)CCCNc1cc(Cl)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL378908 pIC50 109.65 nM
CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1 CHEMBL352764 IC50 110.0 nM
O=C(NCCN1CCOCC1)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210892 IC50 110.0 nM
c1ccc2c(OC[C@H]3CCCN3c3ccnc4ncnn34)cccc2c1 CHEMBL4082542 IC50 110.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4c(F)cccc4Cl)C3=O)ccc2N1 CHEMBL4473359 IC50 110.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)ccc4Cl)C3=O)ccc2N1 CHEMBL4470242 IC50 110.0 nM
Cc1ccccc1-c1c[nH]nn1 CHEMBL196408 Ki app 112.0 nM
CNc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3938175 IC50 113.0 nM
CCOc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3971237 IC50 113.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cncc(OC)c3)cc21 CHEMBL3899307 IC50 114.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccc(N4CCN(C5CC5)CC4)c3)cc2n1CC(F)(F)F CHEMBL3986520 IC50 114.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(N4CCOCC4)cc3)cc21 CHEMBL3957720 IC50 117.0 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)NNc1cccc2ccccc12 CHEMBL354522 IC50 120.0 nM
N[C@H](CC1CCCCC1)[C@H](O)C(=O)N[C@@H](CO)c1ccccc1 CHEMBL169423 IC50 120.0 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)N(C)Cc1cccc2ccccc12 CHEMBL171713 IC50 120.0 nM
CCN(CC)CCCCc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209053 EC50 120.0 nM
CCN(CC)CCCC(C)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL210342 EC50 120.0 nM
O=c1c2c[nH]nc2c2ccc(-c3cccc(N4CCCC4)n3)cc2n1CC(F)(F)F CHEMBL3902470 IC50 120.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)c(F)c(F)c4)C3=O)ccc2N1 CHEMBL4444681 IC50 120.0 nM
Cc1ccc(-n2[se]c3ccccc3c2=O)c(Cl)c1 CHEMBL3932329 IC50 121.0 nM
CCN(CC)CCC(C)Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL1254559 pIC50 128.82 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1 CHEMBL170733 IC50 130.0 nM
CC(C)SCC[C@@H](N)[C@H](O)C(=O)N(C)Cc1cccc2ccccc12 CHEMBL353100 IC50 130.0 nM
N#Cc1ccc(N2CC[C@](O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)cc1 CHEMBL4559822 IC50 130.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3)cc2n1CC1CC1 CHEMBL3911920 IC50 133.0 nM
COC(=O)c1ccc(Nc2nnc(SCc3ccccc3C)[nH]2)cc1 CHEMBL242664 Ki app 135.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(OC)cc3F)cc21 CHEMBL3955433 IC50 135.0 nM
CN1CCN(C(=O)c2ccccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 CHEMBL3916578 IC50 138.0 nM
N[C@H](CC1CCCCC1)[C@H](O)C(=O)NNc1cccc2ccccc12 CHEMBL169681 IC50 140.0 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)N[C@@H](CO)c1ccccc1 CHEMBL353805 IC50 140.0 nM
O=C(NCCC1CCCC1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4441859 IC50 140.0 nM
O=C(NCc1cccc(F)c1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4584721 IC50 140.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(N)nc3)cc21 CHEMBL3933127 IC50 142.0 nM
O=c1c2c[nH]nc2c2ccc(Nc3cccnc3)cc2n1CC(F)(F)F CHEMBL3971198 IC50 142.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccc3N)cc21 CHEMBL3911177 IC50 143.0 nM
COc1ccccc1-c1c[nH]nn1 CHEMBL372363 Ki app 150.0 nM
O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCC2CCCN2CC2CCCCC2)ccc2c1CCCC2 CHEMBL384911 IC50 150.0 nM
CCN(CC)CCCNc1cc(C)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209926 IC50 150.0 nM
CCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1C CHEMBL230173 IC50 150.0 nM
CCN(CC)c1ccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)cc1 CHEMBL3912243 IC50 151.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccn3)cc21 CHEMBL3984025 IC50 155.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc4c(c3)OCCN4C)cc21 CHEMBL3896527 IC50 157.0 nM
COc1cc(NC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)ccc1NC(=O)[C@@H](O)[C@H](N)CCc1ccccc1 CHEMBL322131 IC50 158.0 nM
CCCn1c(=O)c2cn[nH]c2c2ccc(-c3ccncc3)cc21 CHEMBL3980784 IC50 158.0 nM
N[C@H](CC1CCCCC1)[C@H](O)C(=O)NCc1ccc2ccccc2c1 CHEMBL172634 IC50 160.0 nM
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4ccc(F)c(Cl)c4F)C3=O)ccc2N1 CHEMBL4575412 IC50 160.0 nM
O=C(O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3892692 IC50 164.0 nM
CCOc1ccc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CCc3ccccc3)cc2)cc1 CHEMBL109002 IC50 169.0 nM
Cc1ccc(NNC(=O)[C@@H](O)[C@H](N)CC2CCCCC2)cc1 CHEMBL354739 IC50 170.0 nM
CCN(CC)CCCC(C)NC(=O)c1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL426324 IC50 170.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccc3CN3CCOCC3)cc21 CHEMBL3974055 IC50 170.0 nM
O=C(NCCc1ccco1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4441472 IC50 170.0 nM
COc1cc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2)cc(OC)c1OC CHEMBL110672 IC50 177.0 nM
CCN(CC)CCCOc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209368 IC50 180.0 nM
CCN(CC)CCCNc1ccc(F)cc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL208947 IC50 180.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccc3N(C)C)cc21 CHEMBL3892894 IC50 180.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cc(OC)ccc3Cl)cc21 CHEMBL3921036 IC50 181.0 nM
CCn1c(=O)c2c[nH]nc2c2ccc(-c3cccnc3)cc21 CHEMBL3918531 IC50 188.0 nM
CN(Cc1cccc2ccccc12)C(=O)[C@@H](O)[C@H](N)CCc1ccccc1 CHEMBL166829 IC50 190.0 nM
CC(C)SCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 CHEMBL170271 IC50 190.0 nM
NC(=O)c1cc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2cc1-c1ccncc1 CHEMBL3898086 IC50 198.0 nM
N[C@H](CC1CCCCC1)[C@H](O)C(=O)NOc1ccccc1 CHEMBL166381 IC50 200.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccncc3)cc21 CHEMBL3934362 IC50 200.0 nM
CO[C@H]1[C@@H](OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)CC[C@]2(CO2)[C@@H]1[C@@]1(C)O[C@@H]1CC=C(C)C CHEMBL4077166 IC50 200.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3)cc2n1CC1CC1(F)F CHEMBL3897896 IC50 206.0 nM
O=C(Cc1cccc(Cl)c1)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3910783 IC50 206.0 nM
CC(C)OC(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3928569 IC50 207.0 nM
CCOc1ccc(CCC(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2)cc1 CHEMBL108791 IC50 209.0 nM
CCSCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1ccc2ccccc2c1 CHEMBL170667 IC50 210.0 nM
CCOc1ccc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2)cc1 CHEMBL420111 IC50 217.0 nM
Cc1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3798111 IC50 220.0 nM
CCn1c(=O)c2c[nH]nc2c2ccc(-c3ccc(F)cc3)cc21 CHEMBL3910761 IC50 220.0 nM
COc1ccc(Cn2nnc3c2[C@]2(CC[C@H]3OC(=O)NC(C)C)CO2)cc1 CHEMBL4555571 IC50 220.0 nM
Cc1ccc(CCNC(=O)[C@@]2(O)CCN(c3ccccc3)C2=O)s1 CHEMBL4463329 IC50 220.0 nM
O=C(O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3970196 IC50 223.0 nM
COc1cc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2C)cc(OC)c1OC CHEMBL323201 IC50 230.0 nM
O=C(Nc1ccccc1)c1ccccc1[Se][Se]c1ccccc1C(=O)Nc1ccccc1 CHEMBL385817 IC50 230.0 nM
c1cc(OC[C@H]2CCCN2c2ncnc3[nH]cnc23)c2ccncc2c1 CHEMBL4093791 IC50 230.0 nM
C[C@H](NC(=O)[C@@H](O)[C@H](N)C1CCCCC1)c1cccc2ccccc12 CHEMBL353506 IC50 240.0 nM
CCOc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC)c2c1 CHEMBL3973832 IC50 240.0 nM
CCn1c(=O)c2cn[nH]c2c2cc(Cl)c(-c3ccncc3)cc21 CHEMBL3927326 IC50 240.0 nM
O=C(NCc1cccc(Cl)c1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4549484 IC50 240.0 nM
CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1ccc2ccccc2c1 CHEMBL171313 IC50 250.0 nM
CC(C)SCC[C@@H](N)[C@H](O)C(=O)N[C@@H](CO)c1ccccc1 CHEMBL167833 IC50 250.0 nM
c1cncc(-c2cnn[nH]2)c1 CHEMBL373134 Ki app 260.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccccc3CN(C)C)cc21 CHEMBL3918904 IC50 260.0 nM
NC(=O)c1cccc(NC(=O)c2ccccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)c1 CHEMBL3892093 IC50 267.0 nM
CC1CN(c2cccc(-c3ccc4c5n[nH]cc5c(=O)n(CC(F)(F)F)c4c3)n2)CC(C)O1 CHEMBL3970089 IC50 268.0 nM
CC(C)CSC[C@@H](N)[C@H](O)C(=O)NCCc1ccc(Cl)cc1Cl CHEMBL168268 IC50 270.0 nM
CCSCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1 CHEMBL169958 IC50 270.0 nM
O=C(NCc1ccccc1Cl)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4589384 IC50 270.0 nM
CC(C)n1c(=O)c2cn[nH]c2c2ccc(-c3ccncc3)cc21 CHEMBL3907061 IC50 274.0 nM
Nc1cccc(-c2c[nH]nn2)c1 CHEMBL198194 Ki app 280.0 nM
COc1c(-c2cn[nH]c2)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(=O)O CHEMBL230385 IC50 280.0 nM
O=C(NCc1ccccc1F)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4556036 IC50 280.0 nM
O=C(Cc1ccc(Cl)cc1Cl)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3980852 IC50 281.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccc(N4CCOCC4)c3)cc21 CHEMBL3957686 IC50 286.0 nM
N[C@H](CC1CCCCC1)[C@H](O)C(=O)NNC(=O)c1cc(Cl)ccc1Cl CHEMBL169319 IC50 290.0 nM
CCCSC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1 CHEMBL169959 IC50 290.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccc(C(F)(F)F)nc3)cc2n1CC(F)(F)F CHEMBL3963445 IC50 294.0 nM
CC(C)Oc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3932678 IC50 298.0 nM
Oc1cccc(-c2c[nH]nn2)c1 CHEMBL198937 Ki app 300.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3NS(=O)(=O)c3ccccc3Oc3ccccc3)cc2n1CC(F)(F)F CHEMBL3961288 IC50 307.0 nM
COc1cc(NC(=O)[C@@H](O)[C@H](N)CC2CCCCC2)ccc1NC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 CHEMBL419018 IC50 308.0 nM
CC(NC(=O)[C@@H](O)[C@H](N)CC1CCCCC1)c1ccc2ccccc2c1 CHEMBL169461 IC50 310.0 nM
N[C@H](CCc1ccccc1)[C@H](O)C(=O)NOc1ccccc1 CHEMBL172623 IC50 310.0 nM
CCn1c(=O)c2c[nH]nc2c2ccc(Oc3cccnc3)cc21 CHEMBL3987083 IC50 317.0 nM
N[C@H](CC1CCCCC1)[C@H](O)C(=O)NCCc1ccc(Cl)cc1Cl CHEMBL171029 IC50 320.0 nM
O=c1c2ccccc2[se]n1Cc1ccccc1 CHEMBL3920474 IC50 320.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(C(=O)O)cc3)cc21 CHEMBL3941395 IC50 320.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3cccc(-n4cccn4)c3)cc21 CHEMBL3908655 IC50 332.0 nM
Nc1ccc(-c2c[nH]nn2)cc1 CHEMBL194325 Ki app 337.0 nM
Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C(=O)O)c1 CHEMBL209317 IC50 350.0 nM
Fc1ccccc1CSc1nnc(Nc2ccccc2-c2ccccc2)[nH]1 CHEMBL446710 Ki app 350.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc(C#N)s3)cc21 CHEMBL3903137 IC50 351.0 nM
CCn1c(=O)c2cn[nH]c2c2ccc(-c3ccc4[nH]ccc4c3)cc21 CHEMBL3940164 IC50 354.0 nM
COc1cc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CCC3CCCCC3)cc2)cc(OC)c1OC CHEMBL110873 IC50 356.0 nM
CS(=O)(=O)c1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3799532 IC50 360.0 nM
O=c1c2cn[nH]c2c2ccc(-c3cccc(N4CCOCC4)n3)cc2n1CC(F)(F)F CHEMBL3923729 IC50 362.0 nM
COc1cccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)n1 CHEMBL3916295 IC50 373.0 nM
CO[C@@H](C(=O)N[C@H]1CC[C@@H](OC(=O)C2CCCCC2)CNC1=O)[C@H](O)[C@@H](O)[C@H](O)/C(C)=C/C(C)(C)C CHEMBL4089242 IC50 380.0 nM
O=C(NCc1cccs1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4447796 IC50 380.0 nM
CN(c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)C1CCCCC1 CHEMBL3907914 IC50 382.0 nM
O=c1c2cn[nH]c2c2ccc(-c3ccncc3)cc2n1CCF CHEMBL3898256 IC50 390.0 nM
CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)C)C(=O)NC1 CHEMBL256279 IC50 400.0 nM
CO[C@@H](C(=O)N[C@H]1CC[C@@H](OC(=O)C2CCCCC2)CNC1=O)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)(C)C CHEMBL4078211 IC50 400.0 nM
Cc1ccsc1CNC(=O)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4543409 IC50 410.0 nM
N[C@H](CCc1ccccc1)[C@H](O)C(=O)N[C@@H](CO)c1ccccc1 CHEMBL168390 IC50 420.0 nM
COc1ncc(Cl)cc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 CHEMBL3960174 IC50 425.0 nM
C[C@@H]1CN(C(=O)c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)C[C@H](C)O1 CHEMBL3942352 IC50 426.0 nM
CCCSC[C@@H](N)[C@H](O)C(=O)NNc1ccc(C)cc1 CHEMBL165636 IC50 430.0 nM
CN1CCCC1CCOc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL377804 IC50 430.0 nM
O=C(O)c1cc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2cc1-c1ccncc1 CHEMBL3958212 IC50 434.0 nM
O=C(NCc1ccccc1)[C@@]1(O)CCN(c2ccccc2)C1=O CHEMBL4464827 IC50 440.0 nM
c1ccc2c(OC[C@H]3CCCN3c3ncnc4[nH]cnc34)cccc2c1 CHEMBL4070008 IC50 450.0 nM
COc1cccc(NC(=O)[C@@H](O)[C@H](N)CC2CCCCC2)c1 CHEMBL440746 IC50 460.0 nM
CCOC(=O)[C@H](C)NC(=O)C(O)[C@H](N)CCc1ccccc1 CHEMBL169592 IC50 460.0 nM
CC(C)SCC[C@@H](N)[C@H](O)C(=O)NCCc1ccc(Cl)cc1Cl CHEMBL172291 IC50 480.0 nM
CC(C)=CCSc1nnc(Nc2ccccc2-c2ccccc2)[nH]1 CHEMBL245053 Ki app 480.0 nM
Cc1ccc(CNC(=O)[C@@]2(O)CCN(c3ccccc3)C2=O)s1 CHEMBL4469283 IC50 480.0 nM
CN1CCN(C/C=C/c2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC1 CHEMBL211019 IC50 490.0 nM
N[C@H](CCc1ccccc1)[C@H](O)C(=O)NNc1cccc2ccccc12 CHEMBL354202 IC50 500.0 nM
CN(Cc1cccc2ccccc12)C(=O)[C@@H](O)[C@H](N)CC1CCCCC1 CHEMBL171084 IC50 500.0 nM
COC1C(OC(=O)/C=C/C=C/C=C/C=C/C(=O)NCCOCCOCCNCc2cccc(OCc3ccccc3)c2)CCC2(CO2)C1C1(C)OC1CC=C(C)C CHEMBL5404861 DC50 500.0 nM
Cc1ccccc1N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O CHEMBL4576078 IC50 540.0 nM
CC(C)c1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3799684 IC50 550.0 nM
CC(C)c1ccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)c(Cl)n1 CHEMBL3986230 IC50 550.0 nM
Cc1cccc(CNC(=O)[C@@]2(O)CCN(c3ccccc3)C2=O)c1 CHEMBL4587873 IC50 550.0 nM
N[C@H](CC1CCCCC1)[C@H](O)C(=O)NNC(=O)c1ccc2ccccc2c1 CHEMBL353170 IC50 560.0 nM
c1ccc2c(OC[C@H]3CCCN3c3ccnc4nccn34)cccc2c1 CHEMBL4083510 IC50 560.0 nM
CCOC(=O)[C@H](C)NC(=O)C(O)[C@H](N)CCC1CCCCC1 CHEMBL434309 IC50 590.0 nM
O=C1NCC[C@]1(O)C(=O)NCc1cc(F)cc(Cl)c1 CHEMBL4444678 IC50 590.0 nM
CCOC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)CC1CCCCC1 CHEMBL354728 IC50 600.0 nM
CCOC(=O)[C@H](C)NC(=O)C(O)[C@H](N)CC1CCCCC1 CHEMBL355657 IC50 600.0 nM
CCCSC[C@@H](N)[C@H](O)C(=O)NCCc1ccc(Cl)cc1Cl CHEMBL171107 IC50 620.0 nM
c1ccc(-c2ccccc2Nc2nnc(SCC3CCCCC3)[nH]2)cc1 CHEMBL244620 Ki app 650.0 nM
CCN(CC)CCCNc1ccc(C(F)(F)F)cc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL209458 IC50 690.0 nM
N[C@H](C1CCCCCCC1)[C@H](O)C(=O)NOc1ccccc1 CHEMBL171041 IC50 700.0 nM
Cc1ccccc1OC[C@H]1CCCN1c1ncnc2[nH]cnc12 CHEMBL4097198 IC50 700.0 nM
CN1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O CHEMBL4545625 IC50 700.0 nM
COc1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3799625 IC50 730.0 nM
c1ccc(CSc2nnc(Nc3ccccc3-c3ccccc3)[nH]2)cc1 CHEMBL243103 Ki app 740.0 nM
Cc1csc(CNC(=O)[C@@]2(O)CCN(c3ccccc3)C2=O)c1 CHEMBL4563305 IC50 740.0 nM
COc1cc(/C=C/C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)Cc3ccccc3)cc2)cc(OC)c1OC CHEMBL325806 IC50 755.0 nM
CCN(CC)CCCNc1cc(Cl)c(F)cc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 CHEMBL377964 IC50 790.0 nM
Cc1ccc(NNC(=O)[C@@H](O)[C@H](N)CCc2ccccc2)cc1 CHEMBL171478 IC50 800.0 nM
N[C@H](C1CCCCC1)C(O)C(=O)NOc1ccccc1 CHEMBL172217 IC50 830.0 nM
CCCSC[C@@H](N)[C@H](O)C(=O)N[C@@H](CO)c1ccccc1 CHEMBL168849 IC50 850.0 nM
N#Cc1ccccc1N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O CHEMBL4529723 IC50 860.0 nM
N[C@H](C1CCCCC1)[C@H](O)C(=O)N[C@@H](CO)c1ccccc1 CHEMBL352369 IC50 900.0 nM
N[C@H](C1CCCCC1)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1 CHEMBL171661 IC50 900.0 nM
COc1ccc(C)cc1-n1[se]c2ccccc2c1=O CHEMBL3931605 IC50 920.0 nM
Fc1ccccc1CSc1nnc(-c2ccc3c(c2)OCCO3)n1-c1ccccc1 CHEMBL1829287 IC50 930.0 nM
O=c1c2ccccc2[se]n1-c1cccc(F)c1 CHEMBL3940631 IC50 935.0 nM
Fc1cc(-c2ccccc2)c2cn[nH]c2c1 CHEMBL3798664 IC50 960.0 nM
CCOC(=O)C(C)(C)NC(=O)[C@@H](O)[C@H](N)CC1CCCCC1 CHEMBL169963 IC50 970.0 nM