CC(C)(C)c1cccc(C23CCN(C(=O)[C@H]4C[C@]5(COC(=O)N5)C4)CC2C3)c1 CHEMBL5090028 IC50 0.0072 nM
CC(C)(C)c1ccc(C23CCN(C(=O)[C@H]4C[C@]5(COC(=O)N5)C4)CC2C3)cc1 CHEMBL5283351 IC50 0.019 nM
CC1(c2cccc(C34CCN(C(=O)[C@H]5C[C@]6(COC(=O)N6)C5)CC3C4)c2)CC1 CHEMBL5074982 IC50 0.024 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(c4ccc(-c5ccccc5OC(F)(F)F)cc4)C3)C[C@H]2N1 CHEMBL4749516 IC50 0.03 nM
CC1(c2ccc(C34CCN(C(=O)[C@H]5C[C@]6(COC(=O)N6)C5)CC3C4)cc2)CC1 CHEMBL5282368 IC50 0.034 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(c4ccc(-c5ccc(Cl)cc5Cl)cc4)C3)C[C@H]2N1 CHEMBL4759880 IC50 0.04 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(c4ccc(-c5ccccc5C(F)(F)F)cc4)C3)C[C@H]2N1 CHEMBL4785835 IC50 0.04 nM
CC(C)c1ccc([C@H]2C[C@@H](N(C)C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)cc1 CHEMBL5080928 IC50 0.04 nM
CC(C)(C)Cc1ccc(C2CN(C(=O)N3CC[C@@H]4OCC(=O)N[C@@H]4C3)C2)cc1 CHEMBL4745872 IC50 0.07 nM
Cc1ccc(C23CCN(C(=O)[C@H]4C[C@]5(COC(=O)N5)C4)CC2C3)cc1Cl CHEMBL5280083 IC50 0.075 nM
Cc1ccc([C@@H](c2ccccc2)C2CCN(C(=O)N3CC[C@@H]4OCC(=O)N[C@@H]4C3)CC2)cc1 CHEMBL4756662 IC50 0.1 nM
N#Cc1cccc(Cl)c1-c1ccc(C2CN(C(=O)N3CC[C@@H]4OCC(=O)N[C@@H]4C3)C2)cc1 CHEMBL4749293 IC50 0.1 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(-c3ccc(F)c(F)c3)n2)C1 CHEMBL4097203 IC50 0.18 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(-c3ccccc3)n2)C1 CHEMBL4059676 IC50 0.18 nM
CN(C(=O)[C@H]1C[C@]2(COC(=O)N2)C1)[C@H]1C[C@@H](c2ccc(C(C)(C)C)cc2)C1 CHEMBL5089721 IC50 0.2 nM
CC(C)c1ccc(C23CCN(C(=O)[C@H]4C[C@]5(COC(=O)N5)C4)CC2C3)cc1 CHEMBL5268216 IC50 0.21 nM
Cc1cc([C@H]2C[C@@H](N(C)C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)ccc1C1CC1 CHEMBL5087880 IC50 0.25 nM
CN(C(=O)[C@H]1C[C@]2(COC(=O)N2)C1)[C@H]1C[C@@H](c2ccc(C3(C)CC3)cc2)C1 CHEMBL5092936 IC50 0.25 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2cc(-c3ccccc3)n(-c3ccccc3)n2)C1 CHEMBL4077745 IC50 0.3 nM
Cc1cc(C2CC2)ccc1C12CC1CN(C(=O)[C@H]1C[C@]3(COC(=O)N3)C1)C2 CHEMBL5090735 IC50 0.35 nM
O=C(N1CCC(C(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1)n1cncn1 CHEMBL3087181 IC50 0.36 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2nc(-c3ccccc3)no2)C1 CHEMBL4089505 IC50 0.38 nM
CN(C(=O)[C@H]1C[C@]2(COC(=O)N2)C1)[C@H]1C[C@@H](c2ccc(F)c(C(C)(C)C)c2)C1 CHEMBL5073483 IC50 0.39 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(OCc4ccc(Cl)cc4Oc4ccccc4)C3)C[C@H]2N1 CHEMBL4875383 IC50 0.4 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(Cc3ccccc3)n2)C1 CHEMBL4078217 IC50 0.41 nM
CC1c2nn(C)c(-c3cc(F)cc(F)c3)c2CCN1C(=O)c1cc(F)cc(OCC2CNC(=O)C2)c1Cl CHEMBL5423658 IC50 0.5 nM
Cc1cc(C2CC2)cc([C@H]2C[C@@H](N(C)C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)c1 CHEMBL5075857 IC50 0.52 nM
O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)n1nnc2ccccc21 CHEMBL2159781 IC50 0.54 nM
O=C(N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)n1cncn1 CHEMBL3356971 pIC50 0.5495 nM
O=C(N1CCC(=C(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1)n1cncn1 CHEMBL4216513 IC50 0.562 nM
O=C(c1nccs1)N1CCN(C2CC(=O)N(c3cccc(-c4ccccc4Cl)c3)C2)CC1 CHEMBL4204645 IC50 0.64 nM
CC(C)(C)c1ccc([C@H]2[C@@H]3CN(C(=O)[C@H]4C[C@]5(COC(=O)N5)C4)C[C@@H]32)cc1 CHEMBL5083796 IC50 0.69 nM
O=C(N1CCC(C(O)(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1)n1cncn1 CHEMBL3356985 pIC50 0.6918 nM
O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)n1ccnc1 CHEMBL3356958 IC50 0.7 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(CCc4ccc(C(F)(F)F)cc4Br)C3)C[C@H]2N1 CHEMBL4874643 IC50 0.7 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(-c3cnccn3)n2)C1 CHEMBL4079190 IC50 0.74 nM
O=C(N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)n1cncn1 CHEMBL1232635 pIC50 0.8511 nM
CN(C)C(=O)n1nnc(Cc2ccc(-c3ccccc3)cc2)n1 CHEMBL485841 IC50 0.9 nM
Cc1ccc(COC2CN(C(=O)N3CC[C@@H]4OCC(=O)N[C@@H]4C3)C2C)cc1C(F)(F)F CHEMBL4865707 IC50 0.9 nM
[2H]c1cc([C@H]2[C@@H]3CN(C(=O)[C@H]4C[C@]5(COC(=O)N5)C4)C[C@@H]32)cc(C(C)(C)C)c1 CHEMBL5094858 IC50 0.93 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4075310 IC50 1.0 nM
O=C1CO[C@H]2CCN(C(=O)N3CCC(COc4ccc(C(F)(F)F)cc4Cl)CC3)C[C@H]2N1 CHEMBL4848022 IC50 1.0 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(OCc4ccc(C(F)(F)F)c(Cl)c4)C3)C[C@H]2N1 CHEMBL4871897 IC50 1.0 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(CCc4ccc(C(F)(F)F)cc4F)C3)C[C@H]2N1 CHEMBL4869836 IC50 1.0 nM
C[C@H]1c2nn(C)c(-c3cc(F)cc(F)c3)c2CCN1C(=O)c1cc(F)cc(-c2ccc(=O)[nH]c2)c1Cl CHEMBL5427191 IC50 1.0 nM
O=C(c1ccc(Sc2cccc(C(F)(F)F)c2)cc1)C1CCN(C(=O)c2cc(O)ccc2F)CC1 CHEMBL4870906 Ki 1.1 nM
O=C(c1ccc(Sc2cccc(OC(F)(F)F)c2)cc1)C1CCN(C(=O)c2cc(O)ccc2F)CC1 CHEMBL4866490 Ki 1.12 nM
O=C(c1ccc2c(ccn2-c2ccc(F)cc2)c1)N1CC(N2CCN(C(=O)c3nccs3)CC2)C1 CHEMBL3658400 IC50 1.13 nM
O=C(c1ccc(Sc2cccc(Cl)c2)cc1)C1CCN(C(=O)c2cc(O)ccc2F)CC1 CHEMBL4852896 Ki 1.14 nM
Cc1ccccc1-c1cccc(N2CC(N3CCN(C(=O)c4nccs4)CC3)CC2=O)c1 CHEMBL4205102 IC50 1.2 nM
O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)n1cncn1 CHEMBL3356956 IC50 1.3 nM
CC(C)(C)c1ccc(C23CC2CN(C(=O)[C@H]2C[C@]4(COC(=O)N4)C2)C3)cc1 CHEMBL5082727 IC50 1.4 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCC(N2C(=O)[C@H](c3ccc(F)cc3)[C@H]2c2ccc3c(c2)OCO3)CC1 CHEMBL3785760 IC50 1.41 nM
O=C(c1cc(O)ccc1F)N1CCC(Cc2cccc(Oc3cc(C(F)(F)F)ccn3)c2)CC1 CHEMBL5176915 Ki 1.42 nM
Cc1ccc(COC2CN(C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)cc1Cl CHEMBL4873898 Kd 1.5 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC[C@@]3(c4ccc(C(F)(F)F)cc4)C[C@H]3C1)C2 CHEMBL5092906 IC50 1.6 nM
O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)n1nnc2cccnc21 CHEMBL3356957 pIC50 1.698 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(C3CCOCC3)n2)C1 CHEMBL4102496 IC50 1.9 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccnc(N3CCOCC3)n2)C1 CHEMBL4068332 IC50 1.9 nM
O=C(N1CCN(Cc2cccc(Cl)c2)CC1)n1nnc2ccccc21 CHEMBL2159805 IC50 2.0 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCC(C(O)(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1 CHEMBL576786 IC50 2.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(c2ccn(-c3ccccc3)n2)CC1 CHEMBL4096459 IC50 2.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CC3COCC3C2)CC1 CHEMBL4468636 IC50 2.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CC[C@@H](O)C2)CC1 CHEMBL4437377 IC50 2.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CC[C@H](O)C2)CC1 CHEMBL4522687 IC50 2.0 nM
C[C@H]1c2nn(C)c(-c3cc(F)cc(F)c3)c2CCN1C(=O)c1cc(F)cc(OCC2CNC(=O)O2)c1Cl CHEMBL5400854 IC50 2.0 nM
O=C(c1nccs1)N1CCN(C2CC(=O)N(c3cccc(-c4cccc(Cl)c4)c3)C2)CC1 CHEMBL4205134 IC50 2.2 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CCCC2)CC1 CHEMBL3945728 IC50 2.2 nM
CC1(COc2ccc(F)cc2Cl)CCN(C(=O)[C@H]2C[C@]3(COC(=O)N3)C2)CC1 CHEMBL4854370 IC50 2.7 nM
CC(Oc1ccc(F)cc1Cl)C1CCN(C(=O)[C@H]2C[C@]3(COC(=O)N3)C2)CC1 CHEMBL4860900 IC50 2.7 nM
CCC(Oc1ccc(F)cc1Cl)C1CCN(C(=O)[C@H]2C[C@]3(COC(=O)N3)C2)CC1 CHEMBL4872007 IC50 2.8 nM
O=C(N1CCN(Cc2cccc3ccccc23)CC1)n1nnc2ccccc21 CHEMBL2159780 IC50 3.0 nM
O=C(N1CCC(Cc2ccccc2)CC1)n1nnc2ccccc21 CHEMBL2159800 IC50 3.0 nM
C#Cc1ccc(-n2ccc(C3CN(C(=O)OC(C(F)(F)F)C(F)(F)F)C3)n2)cc1 CHEMBL4078417 IC50 3.0 nM
O=C(O[C@H](CO)C(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4079080 IC50 3.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(C(c2cccnc2)c2cccnc2)CC1 CHEMBL3910417 IC50 3.0 nM
N#Cc1ccnc(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4472033 IC50 3.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(C(O)(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1 CHEMBL3901007 IC50 3.0 nM
C[C@H]1c2nn(C)c(-c3cc(F)cc(F)c3)c2CCN1C(=O)c1cc(F)cc(-c2cc[nH]c(=O)c2)c1Cl CHEMBL5432590 IC50 3.0 nM
COCCOc1cc(Cl)cc(-c2c3c(nn2C)[C@H](C)N(C(=O)c2cccc(OC)c2Cl)CC3)c1 CHEMBL5396984 IC50 3.0 nM
O=C1Nc2ccc(Cl)cc2/C1=N/NC(=O)c1cc(Cl)ccc1O CHEMBL5394671 IC50 3.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(N2CCN(c3ncccn3)CC2)C1 CHEMBL4081625 IC50 3.2 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(OCc3ccc(C(F)(F)F)c(Cl)c3)C1)C2 CHEMBL4868762 IC50 3.2 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CCC(COc3ccc(F)cc3Cl)CC1)C2 CHEMBL4870918 IC50 3.4 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2cccc(Cl)c2N2CCOCC2)CC1 CHEMBL3968032 IC50 3.5 nM
Cc1ncccc1-c1cc(F)cc(N2C[C@H](N3CCN(c4ncccn4)CC3)CC2=O)c1 CHEMBL4213030 IC50 3.6 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 CHEMBL3356976 IC50 3.7 nM
O=C1CO[C@H]2CCN(C(=O)N3CC(CCc4c(F)cccc4C(F)(F)F)C3)C[C@H]2N1 CHEMBL5424652 IC50 3.7 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(OCc3ccc(C(F)(F)F)c(C(F)(F)F)c3)C1)C2 CHEMBL4861633 IC50 3.8 nM
CC(C)(C)c1cccc(C23CC2CN(C(=O)[C@H]2C[C@]4(COC(=O)N4)C2)C3)c1 CHEMBL5079900 IC50 3.8 nM
O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)n1nnc2ncccc21 CHEMBL2159776 IC50 4.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CCN(CCF)CC2)CC1 CHEMBL4468639 IC50 4.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CCC3(CCOCC3)C2)CC1 CHEMBL4450649 IC50 4.0 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 CHEMBL606201 IC50 4.0 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(OCc3ccc(Cl)c(C(F)(F)F)c3)C1)C2 CHEMBL4866307 IC50 4.1 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CCC(C(Oc3ccc(F)cc3Cl)C(F)(F)F)CC1)C2 CHEMBL4871941 IC50 4.2 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(OCc3ccc(Cl)c(Cl)c3)C1)C2 CHEMBL4847556 IC50 4.4 nM
O=C1[C@H](c2ccc(F)cc2)[C@@H](c2ccc3c(c2)OCO3)N1C1CCN(C(=O)n2cncn2)CC1 CHEMBL3785379 IC50 4.6 nM
O=C(c1ccc2c(ccn2-c2ccc(F)cc2)c1)N1CC(N2CCN(c3ncccn3)CC2)C1 CHEMBL5274306 IC50 4.6 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1C[C@@H]3[C@H](C1)[C@H]3c1ccc3c(c1)CCC3)C2 CHEMBL5076546 IC50 4.7 nM
Cc1ncccc1-c1cc(F)cc(N2CC(N3CCN(c4ncccn4)CC3)CC2=O)c1 CHEMBL4210423 IC50 5.0 nM
Cn1cc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(-c2ccccc2Cl)n1 CHEMBL3894067 IC50 5.0 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(OCc3ccc(C(F)(F)F)cc3Cl)C1)C2 CHEMBL4865443 IC50 5.4 nM
Cc1cc(COC2CN(C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)ccc1C(F)(F)F CHEMBL4845748 IC50 5.4 nM
O=C(N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)n1nnc2cccnc21 CHEMBL3356975 pIC50 5.495 nM
O=C(c1ccc(Sc2cccc(Cl)c2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4867862 IC50 5.7 nM
Cc1ccc(C23CC2CN(C(=O)[C@H]2C[C@]4(COC(=O)N4)C2)C3)cc1 CHEMBL5081538 IC50 5.9 nM
CN(C)C(=O)n1nnc(-c2ccc(Oc3cccc(Cl)c3)cc2)n1 CHEMBL2376220 IC50 6.0 nM
O=C(OC(CO)C(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4097100 IC50 6.0 nM
Cn1ncc2cc(C(c3ccc4c(cnn4C)c3)N3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)ccc21 CHEMBL4469632 IC50 6.0 nM
O=C(c1ccc(Sc2cccc(OC(F)(F)F)c2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4875176 IC50 6.2 nM
Cc1ccc(COC2CN(C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)cc1C(F)(F)F CHEMBL4854074 IC50 6.3 nM
Cc1ncccc1-c1cc(F)cc(N2CC(N3CCN(C(=O)c4nccs4)CC3)CC2=O)c1 CHEMBL4205550 IC50 6.5 nM
O=C(CNc1ccc(F)c(Cl)c1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4778803 IC50 6.5 nM
O=C1CC[C@]2(C[C@H](C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)C2)N1 CHEMBL4846513 IC50 6.5 nM
CN(Cc1cccc(-c2ccncc2)c1)C(=O)OC(C(F)(F)F)C(F)(F)F CHEMBL3959117 IC50 6.9 nM
O=C(c1ccc(Sc2cccc(C(F)(F)F)c2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4871787 IC50 6.9 nM
O=C(Nc1ccccc1)c1cccc(CN2CCN(C(=O)n3nnc4ccccc43)CC2)c1 CHEMBL2159812 IC50 7.0 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(OCc3ccc(Cl)cc3Cl)C1)C2 CHEMBL4862009 IC50 7.0 nM
Cc1cc(COC2CN(C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)ccc1Cl CHEMBL4856861 IC50 7.1 nM
O=C(N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)n1nnc2ccccc21 CHEMBL3356974 pIC50 7.762 nM
O=C(N1CCN(Cc2cccc([N+](=O)[O-])c2)CC1)n1nnc2ccccc21 CHEMBL2159806 IC50 8.0 nM
O=C(N1CCN(Cc2ccccc2)CC1)n1nnc2ccccc21 CHEMBL2159798 IC50 8.0 nM
O=C(CNc1c(Cl)cccc1Cl)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4788586 IC50 8.0 nM
O=C(CNc1ccc(F)cc1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4793668 IC50 8.0 nM
N#Cc1cccc(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)n1 CHEMBL4463729 IC50 8.5 nM
O=C(c1nccs1)N1CCN(C2CC(=O)N(c3cccc(-c4ccccc4)c3)C2)CC1 CHEMBL4211832 IC50 8.9 nM
N#Cc1cccc(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4521157 IC50 8.9 nM
O=C(N1CCN(Cc2ccc3ccccc3c2)CC1)n1nnc2ccccc21 CHEMBL2159779 IC50 9.0 nM
O=C(N1CCN(Cc2ccc(Br)cc2)CC1)n1nnc2ccccc21 CHEMBL2159803 IC50 9.0 nM
COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1 CHEMBL570812 IC50 9.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2C[C@H]3CC[C@@H](C2)O3)CC1 CHEMBL4539731 IC50 9.0 nM
O=C(CNc1ccc(Br)cc1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4780294 IC50 9.0 nM
O=C(CNc1ccc(Cl)cc1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4793997 IC50 9.0 nM
O=C(ON1C(=O)CCC1=O)N1CCN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 CHEMBL4203881 IC50 9.1 nM
Cc1ncccc1-c1cccc(N2CC(N3CCN(C(=O)c4nccs4)CC3)CC2=O)c1 CHEMBL4217781 IC50 9.2 nM
O=C(c1nccs1)N1CCN(C2CC(=O)N(c3cccc(-c4ccc(Cl)cc4)c3)C2)CC1 CHEMBL4216838 IC50 9.8 nM
O=C(N1CCN(Cc2ccc(F)cc2)CC1)n1nnc2ccccc21 CHEMBL2159801 IC50 10.0 nM
CN(C)C(=O)n1nnc(Cc2ccc(-c3cccc(O)c3)cc2)n1 CHEMBL2376850 IC50 10.0 nM
O=C(Cn1nnc2ccccc21)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL3318318 IC50 10.0 nM
O=C(c1ccc2nc(C3CCCCC3)oc2c1)N1CC(N2CCN(c3ncccn3)CC2)C1 CHEMBL1615314 IC50 10.0 nM
O=C(c1ccc2c(cnn2-c2ccc(F)cc2)c1)N1CC(N2CCN(C(=O)c3nccs3)CC2)C1 CHEMBL4640364 IC50 10.0 nM
N#Cc1cccc(OC(=O)N2CCN(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4435037 IC50 10.6 nM
O=C(N1CCN(Cc2ccc(Cl)cc2)CC1)n1nnc2ccccc21 CHEMBL2159802 IC50 11.0 nM
O=C(c1nccs1)N1CCN(C2CC(=O)N(c3cccc(Oc4ccccc4)c3)C2)CC1 CHEMBL4212945 IC50 11.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CC[C@H]3CCCN3C2)CC1 CHEMBL4435014 IC50 11.0 nM
CS(=O)(=O)c1ccc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(N2CCCC2)c1 CHEMBL4436074 IC50 11.0 nM
O=C(c1ccc2c(ccn2-c2ccc(F)cc2)c1)N1CC(N2CC(N3Cc4ccccc4C3=O)C2)C1 CHEMBL4638521 IC50 11.0 nM
O=C(c1ccc(Sc2ccccc2)cc1)C1CCN(C(=O)c2cc(O)c(F)cc2F)CC1 CHEMBL4757403 Ki 11.0 nM
O=C1CCC2(CN(C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)C2)N1 CHEMBL4850390 IC50 11.0 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CCC(OCc3ccc(F)cc3Cl)CC1)C2 CHEMBL4872359 IC50 11.0 nM
O=C(N1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1)n1nnc2ccccc21 CHEMBL2159804 IC50 12.0 nM
CN(C)C(=O)n1nnc(-c2ccc(Cn3cccc3)cc2)n1 CHEMBL2376228 IC50 12.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2[C@@H]3CC[C@H]2COC3)CC1 CHEMBL4439400 IC50 12.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 CHEMBL3961694 IC50 12.0 nM
O=C(c1cscn1)N1CCN(C2CN(C(=O)c3sc4cc(C(F)(F)F)ccc4c3Cl)C2)CC1 CHEMBL4635086 IC50 12.0 nM
O=C(NC1CN(C2CN(C(=O)c3ccc4c(ccn4-c4ccc(F)cc4)c3)C2)C1)c1nccs1 CHEMBL4632831 IC50 12.0 nM
O=C(NC1CCCCC1)c1cccc(CN2CCN(C(=O)n3nnc4ccccc43)CC2)c1 CHEMBL2159811 IC50 13.0 nM
Cc1ncccc1-c1cc(N2CC(N3CCN(C(=O)c4nccs4)CC3)CC2=O)ccc1F CHEMBL4207794 IC50 13.0 nM
C[C@H]1c2nn(C)c(-c3cncc(C(F)(F)F)n3)c2CCN1C(=O)c1cc(F)cc(-c2c[nH]c(C#N)c2)c1Cl CHEMBL5420101 IC50 13.0 nM
O=C(c1cccc(O)c1)N1CCC(Cc2cccc(Oc3cc(C(F)(F)F)ccn3)c2)CC1 CHEMBL5206906 IC50 13.1 nM
COc1ccc([C@H]2C(=O)N(C3CCN(C(=O)n4cncn4)CC3)[C@@H]2c2ccc3c(c2)OCO3)cc1 CHEMBL3787340 IC50 13.2 nM
O=C(Nc1cccc(Cl)c1)C1CCN(C(=O)c2ccc3ccccc3c2)CC1 CHEMBL4637658 Ki 13.4 nM
O=C(c1ccc(Sc2ccc(F)c(F)c2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4871592 IC50 13.7 nM
O=C(c1ccc2nc(-c3ccccc3)oc2c1)N1CC(N2CCN(C(=O)c3nccs3)CC2)C1 CHEMBL4642254 IC50 14.0 nM
COc1cccc(C(=O)N2CCc3c(nn(C)c3-c3cc(Cl)cc(CNS(C)(=O)=O)c3)[C@@H]2C)c1Cl CHEMBL5411934 IC50 14.0 nM
CN(C)C(=O)n1nnc(-c2ccc(-n3cccc3)cc2)n1 CHEMBL2376224 IC50 15.0 nM
Cc1cccc(Oc2ccc(-c3nnn(C(=O)N(C)C)n3)cc2)c1 CHEMBL2376221 IC50 15.0 nM
CN(C)C(=O)n1nnc(-c2ccc(Oc3cccc(F)c3)cc2)n1 CHEMBL2376219 IC50 15.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CC3CCC(C2)O3)CC1 CHEMBL4517565 IC50 15.0 nM
O=C(c1ccccc1)N1CCN(C2CN(C(=O)c3ccc4c(ccn4-c4ccc(F)cc4)c3)C2)CC1 CHEMBL4644927 IC50 15.0 nM
O=C1COc2ccc(C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)cc2N1 CHEMBL4870749 IC50 15.0 nM
CN(C)C(=O)n1nnc(Cc2ccc(Oc3ccccc3)cc2)n1 CHEMBL2376209 IC50 16.0 nM
Cc1cc(C)n(CC(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)n1 CHEMBL4779678 IC50 16.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Br)cc2N2CCCC2)CC1 CHEMBL3980354 IC50 17.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CCCCC2)CC1 CHEMBL4550205 IC50 17.0 nM
O=C(Cn1cncn1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4793265 IC50 17.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C\c2ccc(Cl)cc2)cc1 CHEMBL5192320 IC50 17.0 nM
COc1cccc(C(=O)N2CCc3c(nn(C)c3-c3cc(Cl)cc(C4(NS(C)(=O)=O)CC4)c3)[C@@H]2C)c1Cl CHEMBL5407077 IC50 17.0 nM
O=C(c1ccc(Sc2ccc(Cl)cc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4847718 IC50 17.2 nM
Cc1cccc(Sc2ccc(C(=O)C3CCN(C(=O)c4cccc(O)c4)CC3)cc2)c1 CHEMBL4867550 IC50 17.8 nM
Cc1cc(-n2ccc3cc(C(=O)N4CC(N5CCN(C(=O)c6nccs6)CC5)C4)ccc32)cc(F)n1 CHEMBL5290125 IC50 17.8 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CCOCC2)CC1 CHEMBL3920830 IC50 18.0 nM
Cc1ccc(COC2CN(C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)C2)c(Cl)c1 CHEMBL4847831 IC50 18.0 nM
N#Cc1cccc(OC(=O)N2CCN(C3c4ccccc4-c4ccccc43)CC2)c1 CHEMBL4445089 IC50 18.2 nM
O=C(Nc1ccccc1)c1cc(N2CCN(C(=O)n3nnc4ccccc43)CC2)ccc1[N+](=O)[O-] CHEMBL2159795 IC50 19.0 nM
O=C(c1ccco1)N1CCN([C@@H]2CC(=O)N(c3ccc(-c4ccc(F)cc4)cc3)C2)CC1 CHEMBL5089326 IC50 19.0 nM
O=C(N1CCN(c2ccc([N+](=O)[O-])cc2)CC1)n1nnc2ccccc21 CHEMBL2159788 IC50 20.0 nM
Cn1cc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(-c2ccccc2)n1 CHEMBL3979183 IC50 20.0 nM
O=C(c1ccccc1)N1CCN(C2CN(C(=O)c3ccc4c(ccn4-c4ccc(C(F)(F)F)cc4)c3)C2)CC1 CHEMBL4642850 IC50 20.0 nM
O=C(N1CCN(c2ccccc2)CC1)n1nnc2ccccc21 CHEMBL2159797 IC50 21.0 nM
O=C(c1ccc2c(cnn2-c2ccc(F)c(F)c2)c1)N1CC(N2CCN(C(=O)c3cscn3)CC2)C1 CHEMBL4632441 IC50 21.0 nM
O=C(c1ccc(Sc2ccc(OC(F)(F)F)cc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4870413 IC50 21.3 nM
N#Cc1cccc(OC(=O)N2CCC(OC(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4565696 IC50 21.7 nM
N#Cc1cc(O)cc(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4540953 IC50 22.0 nM
O=C(Cn1ccnc1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4797565 IC50 22.0 nM
COc1ccc(/C=N\NC(=O)Nc2ccc(S(C)(=O)=O)cc2)cc1 CHEMBL5195403 IC50 22.0 nM
O=C(N1CCN(Cc2cccc(-c3ccccc3)c2)CC1)n1nnc2ccccc21 CHEMBL2159777 IC50 23.0 nM
CN(C)C(=O)n1nnc(-c2ccc(-n3ccc4ccccc43)cc2)n1 CHEMBL2376227 IC50 23.0 nM
COc1cccc(Sc2ccc(C(=O)C3CCN(C(=O)c4cccc(O)c4)CC3)cc2)c1 CHEMBL4865408 IC50 23.1 nM
COc1ccc([C@H]2C(=O)N(C3CCN(C(=O)n4cncn4)CC3)[C@@H]2c2ccc(OC)cc2)cc1 CHEMBL3785536 IC50 23.3 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4061795 IC50 24.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2)CC1 CHEMBL4584757 IC50 24.0 nM
N#Cc1ccc(-n2ccc3cc(C(=O)N4CC(N5CCN(C(=O)c6cscn6)CC5)C4)ccc32)cc1 CHEMBL4649619 IC50 24.0 nM
O=C(c1ccc(Sc2ccc(C(F)(F)F)cc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4871757 IC50 24.7 nM
C=CCNC(=S)N1C[C@@H]([C@@H](C)OC(=O)NCCc2ccccc2)C1=O CHEMBL2313946 INH 25.0 nM
N#Cc1ccc(F)c(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4548730 IC50 25.0 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(F)OC CHEMBL113262 pIC50 25.12 nM
O=C(O[C@H](CF)C(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4086931 IC50 26.0 nM
CN1CC2CN(c3cc(C(F)(F)F)ccc3CN3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)CC2C1 CHEMBL4546592 IC50 26.0 nM
O=C1COc2ncc(C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)cc2N1 CHEMBL4872139 IC50 26.0 nM
Cc1ccc(Sc2ccc(C(=O)C3CCN(C(=O)c4cccc(O)c4)CC3)cc2)cc1 CHEMBL4857833 IC50 26.1 nM
O=C(c1cc(O)ccc1F)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL5196937 IC50 26.4 nM
CN(C)C(=O)n1nnc(Cc2ccc(-c3cccc(CO)c3)cc2)n1 CHEMBL2376847 IC50 27.0 nM
O=C(c1ccc(Sc2ccccc2)cc1)C1CCN(C(=O)c2cc(O)ccc2F)CC1 CHEMBL4747585 Ki 27.0 nM
O=C1COc2cnc(C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)cc2N1 CHEMBL4855733 IC50 27.0 nM
COc1cccc(C(=O)N2CCc3c(nn(C)c3-c3cc(Cl)cc(CS(N)(=O)=O)c3)[C@@H]2C)c1Cl CHEMBL5413100 IC50 27.0 nM
C[C@H]1c2nn(C)c(-c3cc(F)cc(F)c3)c2CCN1C(=O)c1cc(F)cc(N2CS(=O)(=O)C2)c1Cl CHEMBL5417048 IC50 27.0 nM
COc1cccc(Oc2ccc(-c3nnn(C(=O)N(C)C)n3)cc2)c1 CHEMBL2376222 IC50 28.0 nM
CN(C)C(=O)n1nnc(-c2ccc(Oc3ccccc3)cc2)n1 CHEMBL2376211 IC50 28.0 nM
Cn1nc(-c2ccccc2)cc1CN1CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL3941394 IC50 28.0 nM
O=C(c1ccc2nc(-c3ccccc3)oc2c1)N1CC(N2CCN(C(=O)c3cscn3)CC2)C1 CHEMBL4634718 IC50 28.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(CNS(=O)(=O)c2ccc(Cl)cc2)CC1 CHEMBL4215558 IC50 29.0 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(COc3ccc(F)cc3Cl)C1)C2 CHEMBL4862447 IC50 29.0 nM
O=C1Nc2cc(Cl)ccc2/C1=N\NC(=O)c1c(O)cccc1Cl CHEMBL5177705 IC50 29.0 nM
O=C1Nc2cc(Cl)ccc2/C1=N/NC(=O)c1cc(Cl)ccc1O CHEMBL5427863 IC50 29.0 nM
N#Cc1cccc(OC(=O)N2CCC(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)CC2)c1 CHEMBL4437385 IC50 29.6 nM
O=C(N1CCN(c2ccccc2F)CC1)n1nnc2ccccc21 CHEMBL2159782 IC50 30.0 nM
O=C(c1ccc(Cc2ccccc2)cc1)C1CCN(C(=O)c2cc(O)c(F)cc2F)CC1 CHEMBL4755606 Ki 30.0 nM
COc1nn(-c2ccc(Oc3ccccc3)cc2)c(=O)o1 CHEMBL2171700 IC50 31.0 nM
CC(C)c1ccc(C(=O)C2CCN(C(=O)c3cc(O)c(F)cc3F)CC2)cc1 CHEMBL4758717 IC50 31.0 nM
O=C1[C@@H](c2ccc(F)cc2)[C@H](c2ccc3c(c2)OCO3)N1C1CCN(C(=O)n2cncn2)CC1 CHEMBL3787346 IC50 31.2 nM
COc1ccc(N2CCN(C(=O)n3nnc4ccccc43)CC2)cc1 CHEMBL2159787 IC50 32.0 nM
O=C(c1ccc2c(ccn2-c2nccc(F)n2)c1)N1CC(N2CCN(C(=O)c3nccs3)CC2)C1 CHEMBL4641024 IC50 32.0 nM
O=C1COc2ccc(C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)nc2N1 CHEMBL4867138 IC50 32.0 nM
COc1ccc(Sc2ccc(C(=O)C3CCN(C(=O)c4cccc(O)c4)CC3)cc2)cc1 CHEMBL4865940 IC50 32.3 nM
O=C(N1CCN(Cc2ccccc2-c2ccccc2)CC1)n1nnc2ccccc21 CHEMBL2159778 IC50 33.0 nM
O=C(N1CCN(C/C=C/c2ccccc2)CC1)n1nnc2ccccc21 CHEMBL2159799 IC50 33.0 nM
CN(C)C(=O)n1nnc(-c2ccc(-n3cccn3)cc2)n1 CHEMBL2376226 IC50 33.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CCCC2)CC1 CHEMBL3891077 IC50 34.0 nM
N#Cc1cc(F)cc(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4473440 IC50 34.0 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CC(OCc3ccc(F)cc3Cl)C1)C2 CHEMBL4870417 IC50 34.0 nM
O=C(c1cccc(CN2CCN(C(=O)n3nnc4ccccc43)CC2)c1)N1CCCCC1 CHEMBL2159809 IC50 36.0 nM
CC(=O)c1cc(C)n(-c2ccc(-c3nnn(C(=O)N(C)C)n3)cc2)c1C CHEMBL2376199 IC50 36.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C\c2c(Cl)cccc2Cl)cc1 CHEMBL5174588 IC50 36.0 nM
O=C(c1cccc(O)c1)N1CCC(Cc2cccc(Oc3cccc(C(F)(F)F)n3)c2)CC1 CHEMBL5179781 IC50 36.0 nM
CN(C)C(=O)n1nnc(-c2ccc(Oc3ccc(Cl)cc3)cc2)n1 CHEMBL2376216 IC50 37.0 nM
O=C(c1ccc(Cc2ccccc2)cc1)C1CCN(C(=O)c2cc(O)ccc2F)CC1 CHEMBL4798508 Ki 37.0 nM
O=C(c1cc(N2CCN(C(=O)n3nnc4ccccc43)CC2)ccc1[N+](=O)[O-])N1CCCCC1 CHEMBL2159790 IC50 38.0 nM
O=C(c1nccs1)N1CCN(C2CC(=O)N(c3ccc(Oc4ccccc4)cc3)C2)CC1 CHEMBL4205210 IC50 38.0 nM
O=C1CC[C@@H](CCC(=O)N2CCC(COc3ccc(F)cc3Cl)CC2)N1 CHEMBL4867695 IC50 38.0 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CCC(COc3ccc(F)cc3Cl)C1)C2 CHEMBL4874410 IC50 38.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C\c2ccc(F)cc2)cc1 CHEMBL5207742 IC50 38.0 nM
Cc1cc(C)cc(NC(=O)[C@@H]2CC(=O)N(CCc3c[nH]c4ccc(F)cc34)C2)c1 CHEMBL3318317 IC50 39.0 nM
Cn1ccc(C2CN(C(=O)OC(C(F)(F)F)C(F)(F)F)C2)n1 CHEMBL4104911 IC50 39.0 nM
COc1cc(C#N)cc(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4472005 IC50 39.0 nM
CC(C)c1ccc(C(=O)C2CCN(C(=O)c3cc(O)ccc3F)CC2)cc1 CHEMBL4536045 Ki 39.0 nM
C/C(=N/NC(=O)Nc1ccc(S(C)(=O)=O)cc1)c1ccccc1 CHEMBL5196732 IC50 40.0 nM
O=C(NC1CCCCC1)c1cc(N2CCN(C(=O)n3nnc4ccccc43)CC2)ccc1[N+](=O)[O-] CHEMBL2159794 IC50 41.0 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCC(C(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1 CHEMBL3356981 pIC50 41.69 nM
N#Cc1cccc(OC(=O)N2CCC(Cc3ccccc3)CC2)c1 CHEMBL4444759 IC50 41.9 nM
O=C(c1nccs1)N1CCN(C2CC(=O)N(c3cccc(OCc4ccccc4)c3)C2)CC1 CHEMBL4208034 IC50 44.0 nM
N#Cc1ccc(-n2ccc3cc(C(=O)N4CC(N5CCN(C(=O)c6nccs6)CC5)C4)ccc32)cc1 CHEMBL4644240 IC50 45.0 nM
O=C(N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1)n1cncn1 CHEMBL3401455 pI50 45.71 nM
O=C(ON1C(=O)CCC1=O)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4076777 IC50 46.0 nM
O=C(N1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1)n1cncn1 CHEMBL3402827 pI50 46.77 nM
O=C(c1cccs1)N1CCN(C2CC(=O)N(c3ccc(Oc4ccccc4)cc3)C2)CC1 CHEMBL4216917 IC50 47.0 nM
Cc1ccc(C)n1-c1ccc(-c2nnn(C(=O)N(C)C)n2)cc1 CHEMBL2376225 IC50 48.0 nM
CN(C)C(=O)n1nnc(-c2ccc(Oc3ccc(F)cc3)cc2)n1 CHEMBL2376215 IC50 49.0 nM
O=C(c1ccc(Sc2cccc(F)c2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4878533 IC50 49.7 nM
O=C(c1ccc(Sc2ccc(F)cc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4858780 IC50 50.6 nM
C#Cc1ccc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(N2CCCC2)c1 CHEMBL4529300 IC50 51.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CCCCC2)CC1 CHEMBL4434763 IC50 51.0 nM
Cc1ccccc1C12CCN(C(=O)[C@H]3C[C@]4(COC(=O)N4)C3)CC1C2 CHEMBL5094531 IC50 51.0 nM
Cc1cccnc1-c1cccc(N2CC(N3CCN(C(=O)c4nccs4)CC3)CC2=O)c1 CHEMBL4211452 IC50 53.0 nM
O=C(c1ccc2c(c1)ncn2-c1ccc(F)cc1)N1CC(N2CCN(C(=O)c3nccs3)CC2)C1 CHEMBL4636259 IC50 53.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C\c2ccccc2Cl)cc1 CHEMBL5169919 IC50 53.0 nM
CN(C)C(=O)n1nnnc1Cc1ccc(-c2ccccc2)cc1 CHEMBL509860 IC50 54.4 nM
O=S(=O)(F)CCCCCCCc1ccccc1O CHEMBL2180820 IC50 56.1 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CCC(OCc3ccc(F)cc3Cl)C1)C2 CHEMBL4854188 IC50 58.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CCOCC2)CC1 CHEMBL3952399 IC50 59.0 nM
C=CCNC(=S)N1C[C@@H]([C@@H](C)OC(=O)CCCc2ccccc2)C1=O CHEMBL2313950 INH 60.0 nM
CN(C)C(=O)n1nnnc1-c1ccc(Oc2ccccc2)cc1 CHEMBL2376210 IC50 60.0 nM
COc1ccc([C@H]2C(=O)N(C3CCN(C(=O)n4cncn4)CC3)[C@@H]2c2ccc(OC)c(OC)c2)cc1 CHEMBL3787224 IC50 61.4 nM
O=C(N1CCN(Cc2ccc(-c3ccccc3)cc2)CC1)n1nnc2ccccc21 CHEMBL2159813 IC50 62.0 nM
CN(C)C(=O)c1cc(N2CCN(C(=O)n3nnc4ccccc43)CC2)ccc1[N+](=O)[O-] CHEMBL2159789 IC50 63.0 nM
O=C1CCC(CCC(=O)N2CCC(COc3ccc(F)cc3Cl)CC2)N1 CHEMBL4849041 IC50 63.0 nM
CNS(=O)(=O)Cc1cc(Cl)cc(-c2c3c(nn2C)[C@H](C)N(C(=O)c2cccc(OC)c2Cl)CC3)c1 CHEMBL5399772 IC50 63.0 nM
Cc1ccc(Oc2ccc(-c3nnn(C(=O)N(C)C)n3)cc2)cc1 CHEMBL2376217 IC50 67.0 nM
Cc1cc(C#N)cc(OC(=O)N2CCC(C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4459578 IC50 67.0 nM
O=C(CNc1ccccc1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4786239 IC50 68.0 nM
Cc1cc(Cl)ccc1C(c1ccc(Cl)cc1C)N1CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL3897813 IC50 69.0 nM
O=C(N1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1)n1nnc2ccccc21 CHEMBL3356979 pIC50 69.18 nM
Cc1ccccc1N1CCN(C(=O)n2nnc3ccccc32)CC1 CHEMBL2159783 IC50 71.0 nM
N#Cc1cccc(OC(=O)N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c1 CHEMBL4541769 IC50 72.8 nM
O=C1CCC2(CCN(C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)C2)N1 CHEMBL4859927 IC50 73.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C\c2cccc(Cl)c2Cl)cc1 CHEMBL5190335 IC50 73.0 nM
O=C(c1ccc(Sc2ccccc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4789288 IC50 73.5 nM
CCCCc1ccc(C(=O)C2CCN(C(=O)c3cc(O)ccc3F)CC2)cc1 CHEMBL4575018 IC50 74.0 nM
NS(=O)(=O)c1ccc(NCC(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)cc1 CHEMBL4792393 IC50 74.0 nM
CN(C)C(=O)n1nnc(-c2ccc(Oc3ccc(Cl)c(Cl)c3)cc2)n1 CHEMBL2376223 IC50 75.0 nM
O=C(c1ccc(Cc2ccccc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4758976 IC50 78.0 nM
CN(Cc1ccc2ccccc2c1)C(=O)n1nnc(Cc2ccc(-c3ccccc3)cc2)n1 CHEMBL2376844 IC50 84.5 nM
COc1nn(-c2ccc(Oc3ccccc3)cc2C(F)(F)F)c(=O)o1 CHEMBL4209559 IC50 85.0 nM
O=C(c1ccc(F)c(O)c1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL5180827 IC50 85.8 nM
N#Cc1cccc(OC(=O)N2CCN(C3CC3)CC2)c1 CHEMBL4557262 IC50 89.0 nM
CCOc1nn(-c2cccc(Oc3ccccc3)c2)c(=O)o1 CHEMBL3402828 pIC50 91.2 nM
O=C(c1ccc(Sc2ccc(O)cc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4853706 IC50 96.2 nM
N#Cc1ccc(-n2ccc3cc(C(=O)N4CC(N5CCN(C(=O)c6ccccc6)CC5)C4)ccc32)cc1 CHEMBL4637973 IC50 97.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(N2C(=O)[C@H](c3ccc(F)cc3)[C@H]2c2ccc3c(c2)OCO3)CC1 CHEMBL3787592 IC50 97.5 nM
O=C(N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1)n1nnc2ncccc21 CHEMBL3401457 pI50 97.72 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2cc(Cl)ccc2N2CCOCC2)CC1 CHEMBL3894669 IC50 98.0 nM
CN(C)C(=O)n1nnc(Cc2ccc(-c3ccccc3O)cc2)n1 CHEMBL2376849 IC50 98.1 nM
N#Cc1cccc(OC(=O)N2CCN(C(c3ccccc3)c3cccnc3)CC2)c1 CHEMBL4519763 IC50 100.0 nM
O=C(c1ccc(Sc2cccc(O)c2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4852294 IC50 100.0 nM
CN(C)C(=O)c1cccc(CN2CCN(C(=O)n3nnc4ccccc43)CC2)c1 CHEMBL2159808 IC50 102.0 nM
O=C(c1ccc(Cl)c(O)c1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL5192534 IC50 107.2 nM
O=C(c1ccc(Br)c(O)c1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL5172052 IC50 109.4 nM
CN1CCN(C(=S)SSC(=S)N2CCN(C)CC2)CC1 CHEMBL571699 pIC50 109.65 nM
Cc1cc(C(=O)C(C)(C)C)c(C)n1-c1ccc(-c2nnn(C(=O)N(C)C)n2)cc1 CHEMBL2376201 IC50 110.0 nM
COc1nn(-c2cccc(Oc3ccccc3)c2)c(=O)o1 CHEMBL2171701 IC50 110.0 nM
CC(C)c1ccc(C(=O)C2CCN(C(=O)c3ccc(F)c(O)c3)CC2)cc1 CHEMBL4534867 IC50 110.0 nM
O=S(=O)(F)CCCCCCCc1ccccc1OCc1ccccc1 CHEMBL2180557 IC50 116.1 nM
O=C(Cn1cnc2ccccc21)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4794817 IC50 117.0 nM
O=C(c1ccccc1)N1CCN(C2CN(C(=O)c3ccc4c(cnn4-c4ccccc4)c3)C2)CC1 CHEMBL4637347 IC50 119.0 nM
Cc1ccccc1-c1ccc(Cc2nnn(C(=O)N(C)C)n2)cc1 CHEMBL2376853 IC50 121.4 nM
O=C(c1cc(O)ccc1Cl)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL5188296 IC50 124.6 nM
N#Cc1cccc(OC(=O)N2CCN(C3CCCCC3)CC2)c1 CHEMBL4441719 IC50 127.0 nM
O=C(c1ccc(C2CCCCC2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4798272 IC50 129.0 nM
S=C(SSC(=S)C1CCCCC1)C1CCCCC1 CHEMBL4218595 IC50 130.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C2/C(=O)Nc3ccccc32)cc1 CHEMBL5188287 IC50 130.0 nM
O=C(N1CCN(c2ccccc2)CC1)n1cncn1 CHEMBL3356960 pIC50 131.83 nM
O=C(OC[C@@H](O)C(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4059563 IC50 132.0 nM
O=C(c1cccc(O)c1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL5179066 IC50 133.9 nM
CCCCc1ccc(C(=O)C2CCN(C(=O)c3cccc(O)c3)CC2)cc1 CHEMBL4436371 IC50 136.0 nM
CN(C)C(=O)n1nnc(Cc2ccc(-c3cccc(C(N)=O)c3)cc2)n1 CHEMBL2376852 IC50 137.2 nM
CC(C)c1ccc(C(=O)C2CCN(C(=O)c3cccc(O)c3)CC2)cc1 CHEMBL4435479 IC50 138.0 nM
Cc1cccc(-c2ccc(Cc3nnn(C(=O)N(C)C)n3)cc2)c1 CHEMBL2376854 IC50 139.2 nM
O=C(c1cccc(O)c1)N1CCC(Cc2cccc(Oc3ccccn3)c2)CC1 CHEMBL5203586 IC50 139.3 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCN1C(=O)C=CC1=O CHEMBL561924 IC50 140.0 nM
CCCCCCCCN1SCCC1=O CHEMBL1922512 IC50 140.0 nM
Cc1ccc(C)n1Cc1ccc(-c2nnn(C(=O)N(C)C)n2)cc1 CHEMBL2376229 IC50 140.0 nM
O=C1CC(N2CCN(c3ncccn3)CC2)CN1c1ccc(Oc2ccccc2)cc1 CHEMBL4210880 IC50 140.0 nM
CN1CCN(C(=O)c2cc(N3CCN(C(=O)n4nnc5ccccc54)CC3)ccc2[N+](=O)[O-])CC1 CHEMBL2159792 IC50 141.0 nM
CN(C(=S)SSC(=S)N(C)C1CCCCC1)C1CCCCC1 CHEMBL576697 pIC50 141.25 nM
O=C(c1cccc(O)c1)N1CCC(Cc2cccc(Oc3ccccc3)c2)CC1 CHEMBL5194389 IC50 148.7 nM
O=C(CNC1CCCCC1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4777523 IC50 151.0 nM
CC(C)(C)c1ccc(CN2CCN(C(=S)Sc3ccc([N+](=O)[O-])cc3[N+](=O)[O-])CC2)cc1 CHEMBL2158989 pIC50 154.88 nM
O=S(=O)(F)CCCCOc1ccc(OCc2ccccc2)cc1 CHEMBL2180822 IC50 156.2 nM
O=C(c1cc(N2CCN(C(=O)n3nnc4ccccc43)CC2)ccc1[N+](=O)[O-])N1CCOCC1 CHEMBL2159791 IC50 162.0 nM
CCCc1ccc(C(=O)C2CCN(C(=O)c3cccc(O)c3)CC2)cc1 CHEMBL4449639 IC50 162.0 nM
S=C(SSC(=S)N1CCN(C2CCCCC2)CC1)N1CCN(C2CCCCC2)CC1 CHEMBL570565 pIC50 165.96 nM
CN(C)C(=O)n1nnnc1Cc1ccc(-c2cccc(O)c2)cc1 CHEMBL2376864 IC50 170.9 nM
O=C(c1cccc(O)c1)N1CCC(Cc2cccc(Oc3ncccc3C(F)(F)F)c2)CC1 CHEMBL5180084 IC50 175.7 nM
Cc1cc(C(=O)c2ccccc2)c(C)n1-c1ccc(-c2nnn(C(=O)N(C)C)n2)cc1 CHEMBL2376200 IC50 180.0 nM
C#CCN1C(=O)/C(=N/NC(=O)Nc2ccc(S(C)(=O)=O)cc2)c2cc(Cl)ccc21 CHEMBL5188078 IC50 180.0 nM
COc1ccc(Oc2ccc(-c3nnn(C(=O)N(C)C)n3)cc2)cc1 CHEMBL2376218 IC50 190.0 nM
O=C1CCC(COC(=O)N2CCC(COc3ccc(F)cc3Cl)CC2)N1 CHEMBL4870350 IC50 190.0 nM
O=S(=O)(F)CCCCCCCc1cccc(O)c1 CHEMBL2180819 IC50 190.3 nM
CCc1ccc(C(=O)C2CCN(C(=O)c3cccc(O)c3)CC2)cc1 CHEMBL4474818 IC50 194.0 nM
O=C(Cn1ccc2ccccc21)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4793077 IC50 196.0 nM
N#Cc1cccc(OC(=O)N2CCN(C3CCCC3)CC2)c1 CHEMBL4540684 IC50 200.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C\c2ccc(Cl)cc2Cl)cc1 CHEMBL5191646 IC50 200.0 nM
O=S(=O)(F)CCCCCc1ccc(OCc2ccccc2)cc1 CHEMBL2180817 IC50 201.3 nM
O=C1N[C@]2(CO1)C[C@H](C(=O)N1CCC3(c4ccccc4)C(C1)C3(F)F)C2 CHEMBL5072209 IC50 203.0 nM
O=C(N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1)n1nnc2ccccc21 CHEMBL3401456 IC50 208.0 nM
CN(C)C(=O)n1nnc(Cc2ccc(-c3ccc(O)cc3)cc2)n1 CHEMBL2376851 IC50 209.4 nM
S=C(SSC(=S)N1CCOCC1)N1CCOCC1 CHEMBL121556 pIC50 218.78 nM
CN(C)C(=O)n1nnc(-c2ccc(Cn3ccc4ccccc43)cc2)n1 CHEMBL2376198 IC50 220.0 nM
O=C(NCCCCCn1ccc2ccccc21)Oc1cccnc1 CHEMBL3585527 IC50 220.0 nM
C=CCN1C(=O)/C(=N/NC(=O)Nc2ccc(S(C)(=O)=O)cc2)c2ccccc21 CHEMBL5192976 IC50 220.0 nM
O=C(N1CCN(c2ccccc2[N+](=O)[O-])CC1)n1nnc2ccccc21 CHEMBL2159784 IC50 224.0 nM
CC(C)N1CCN(C(=O)Oc2cccc(C#N)c2)CC1 CHEMBL4458891 IC50 224.0 nM
Cc1nn(-c2ccccc2)cc1CN1CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL3970987 IC50 230.0 nM
CC(C)NC(=O)c1cc(N2CCN(C(=O)n3nnc4ccccc43)CC2)ccc1[N+](=O)[O-] CHEMBL2159793 IC50 234.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2cc(O)ccc2F)CC1 CHEMBL4472877 IC50 240.0 nM
CC(OC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1)C(F)(F)F CHEMBL4092367 IC50 242.0 nM
O=C(CNCc1ccccc1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4780477 IC50 242.0 nM
O=S(=O)(F)CCCCCCCc1ccc(OCc2ccccc2)cc1 CHEMBL2180830 IC50 248.9 nM
CN(CCCCc1ccccc1)C(=O)n1nnc(Cc2ccc(-c3ccccc3)cc2)n1 CHEMBL2376843 IC50 250.0 nM
N#Cc1cccc(OC(=O)N2CCC(NC(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4593081 IC50 250.0 nM
COc1nn(Cc2ccc(N(c3ccccc3)c3ccccc3)cc2)c(=O)o1 CHEMBL3087179 pIC50 251.19 nM
COc1ccc([C@H]2C(=O)N(C3CCN(C(=O)n4cncn4)CC3)[C@@H]2c2ccc(OC)c(OC)c2)cc1OC CHEMBL3786142 IC50 251.3 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(C(c2ccccc2)c2ccccc2)CC1 CHEMBL3352862 IC50 257.0 nM
CCCCc1ccc(C(=O)C2CCN(C(=O)c3ccc(F)c(O)c3)CC2)cc1 CHEMBL4466342 IC50 262.0 nM
CC1CCN(C(=S)SSC(=S)N2CCC(C)CC2)CC1 CHEMBL576671 pIC50 269.15 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(C(c2cocn2)c2cocn2)CC1 CHEMBL3986768 IC50 270.0 nM
O=C(N1CCN(c2ccccc2)CC1)n1nnc2cccnc21 CHEMBL3356959 IC50 275.0 nM
O=C(c1ccc(Oc2ccccc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4746545 IC50 278.0 nM
CS(=O)(=O)c1ccc(NC(=O)NN=C(c2ccccc2)c2ccccc2)cc1 CHEMBL5202899 IC50 280.0 nM
O=C(CN1CCCCC1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4776276 IC50 282.0 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 CHEMBL5203286 IC50 284.0 nM
CN(C)C(=O)n1nnnc1Cc1ccc(Oc2ccccc2)cc1 CHEMBL2376208 IC50 310.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccccc2N2CCCC2)CC1 CHEMBL4533439 IC50 310.0 nM
S=C(SSC(=S)N1CCSCC1)N1CCSCC1 CHEMBL573920 pIC50 316.23 nM
S=C(SSC(=S)N1CCCCC1)N1CCCCC1 CHEMBL121516 pIC50 316.23 nM
CN1CCN(C(=O)c2cccc(CN3CCN(C(=O)n4nnc5ccccc54)CC3)c2)CC1 CHEMBL2159810 IC50 324.0 nM
COc1cccc(C(=O)N2CCC(C(=O)Nc3cccc(Cl)c3)CC2)c1 CHEMBL1899736 IC50 333.1 nM
Cc1ccc(-c2ccc(Cc3nnn(C(=O)N(C)C)n3)cc2)cc1 CHEMBL2376855 IC50 334.9 nM
COc1nn([C@H](C)c2ccc(N(c3ccccc3)c3ccccc3)cc2)c(=O)o1 CHEMBL3087171 pIC50 338.84 nM
O=C(N1CCCCC1)n1nnc(Cc2ccc(-c3ccccc3)cc2)n1 CHEMBL2376841 IC50 346.5 nM
S=C(SSC(=S)N1CCc2ccccc2C1)N1CCc2ccccc2C1 CHEMBL583524 pIC50 346.74 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL602499 pIC50 346.74 nM
COC[C@@H](OC(=O)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1)C(F)(F)F CHEMBL4068209 IC50 354.0 nM
O=[N+]([O-])c1ccc(SC(=S)N2CCN(C(c3ccccc3)c3ccccc3)CC2)c([N+](=O)[O-])c1 CHEMBL2158918 pIC50 354.81 nM
CCN(CC)C(=S)SSC(=S)N(CC)CC CHEMBL964 IC50 360.0 nM
O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccccc1O CHEMBL4476621 IC50 363.0 nM
Cc1ccc(C(=O)C2CCN(C(=O)c3cccc(O)c3)CC2)cc1 CHEMBL4559346 IC50 368.0 nM
O=C(c1ccc(C2CC2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4794653 IC50 368.0 nM
CCCCCC(=O)c1cc(C)n(-c2ccc(-c3nnn(C(=O)N(C)C)n3)cc2)c1C CHEMBL2376202 IC50 370.0 nM
CC(C)NC(=O)c1ccc(N2CCN(C(=O)n3nnc4ccccc43)CC2)c([N+](=O)[O-])c1 CHEMBL2159785 IC50 372.0 nM
CN(C)C(=O)n1nnc(Cc2ccc(-c3ccc(CO)cc3)cc2)n1 CHEMBL2376848 IC50 372.2 nM
O=C(N1CCC(N2C[C@H](c3ccc(F)cc3)[C@H]2c2ccc3c(c2)OCO3)CC1)n1cncn1 CHEMBL3787453 IC50 376.0 nM
O=C(c1ncco1)N1CCN(C2CC(=O)N(c3ccc(Oc4ccccc4)cc3)C2)CC1 CHEMBL4203751 IC50 380.0 nM
O=S(=O)(F)CCCCCc1ccc(O)cc1 CHEMBL2180821 IC50 383.1 nM
O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2ccc(F)c(O)c2)CC1 CHEMBL4549211 IC50 389.0 nM
Cc1cccc(Cn2nc(C(=O)N3CCC(Cc4ccccc4)CC3)cc2-c2ccc(O)cc2)c1 CHEMBL4078924 IC50 390.0 nM
COc1nn(Cc2ccc(Oc3ccccc3)cc2)c(=O)o1 CHEMBL3087178 pIC50 398.11 nM
O=c1c2ccccc2sn1Cc1ccc(-c2ccccc2)cc1 CHEMBL1922515 IC50 410.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2ccc(Cl)c(O)c2)CC1 CHEMBL4471924 IC50 424.0 nM
O=S(=O)(F)CCCCCCCc1ccc(O)cc1 CHEMBL2180818 IC50 427.1 nM
CN(Cc1ccccc1)C(=S)SSC(=S)N(C)Cc1ccccc1 CHEMBL571274 pIC50 436.52 nM
O=[N+]([O-])c1ccc(SC(=S)N2CCN(Cc3ccc(Br)cc3)CC2)c([N+](=O)[O-])c1 CHEMBL2158988 pIC50 436.52 nM
O=C(OCC(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4104811 IC50 445.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2ccc(Br)c(O)c2)CC1 CHEMBL4463252 IC50 457.0 nM
O=C(NCCCCCCn1ccc2ccccc21)Oc1cccnc1 CHEMBL3585528 IC50 460.0 nM
O=C(c1ccc(-c2ccccc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4784531 IC50 460.0 nM
COc1ccc(-c2ccc(COC3(c4cccnc4)CN(C#N)C3)c(F)c2)cc1F CHEMBL4638402 IC50 472.0 nM
CC1CCCC(C)N1C(=S)SSC(=S)N1C(C)CCCC1C CHEMBL571273 pIC50 478.63 nM
NC(=O)c1cn(-c2cccc(OC(=O)NCCCCCCc3ccccc3)c2)nn1 CHEMBL5420923 IC50 479.0 nM
S=C(SSC(=S)N1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1 CHEMBL569626 pIC50 489.78 nM
COC(=O)c1cccc(-c2ccc(Cc3nnn(C(=O)N(C)C)n3)cc2)c1 CHEMBL2376846 IC50 498.5 nM
CC(=O)N1CCC(c2nn(C)cc2CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)CC1 CHEMBL4458086 IC50 510.0 nM
COc1nn(Cc2ccc(OCc3ccccc3)cc2)c(=O)o1 CHEMBL3613663 IC50 520.0 nM
CN(C)C(=O)n1nnnc1Cc1ccc(-c2cccc(CO)c2)cc1 CHEMBL2376861 IC50 520.2 nM
O=C(c1ccc2c(ccn2-c2nccc(F)n2)c1)N1CC(N2CCN(C(=O)c3cscn3)CC2)C1 CHEMBL4639861 IC50 559.0 nM
COc1nn(Cc2ccc(NC(=O)c3ccccc3)cc2)c(=O)o1 CHEMBL3613661 IC50 560.0 nM
COc1cccc(C(=O)N2CCC(C(=O)Nc3ccc(Cl)cc3)CC2)c1 CHEMBL4639080 IC50 575.7 nM
O=C(O[C@H](CCO)C(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4081518 IC50 582.0 nM
O=C1CC[C@H](CCC(=O)N2CCC(COc3ccc(F)cc3Cl)CC2)N1 CHEMBL4876184 IC50 590.0 nM
CN(C(=O)n1nnc(Cc2ccc(-c3ccccc3)cc2)n1)C1CCCCC1 CHEMBL2376842 IC50 601.5 nM
C=CCN1C(=O)/C(=N/NC(=O)Nc2ccc(S(C)(=O)=O)cc2)c2cc(Cl)ccc21 CHEMBL5184756 IC50 620.0 nM
COc1nn(C(C)c2ccc(N(c3ccccc3)c3ccccc3)cc2)c(=O)o1 CHEMBL3087191 IC50 630.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 CHEMBL3402819 IC50 645.0 nM
Cc1cc(C(=O)c2ccc(-c3ccccc3)cc2)c(C)n1-c1ccc(-c2nnn(C(=O)N(C)C)n2)cc1 CHEMBL2376203 IC50 650.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4282040 Ki 650.0 nM
CCCCCCCCn1sc2ccccc2c1=O CHEMBL1922513 IC50 660.0 nM
O=C(N1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1)n1ccnc1 CHEMBL3356980 IC50 660.0 nM
O=C(Nc1ccc(Cl)cc1)C1CCN(C(=O)c2ccc(O)cc2)CC1 CHEMBL4645190 IC50 662.1 nM
O=C(O)c1cccc(CN2CCN(C(=O)n3nnc4ccccc43)CC2)c1 CHEMBL2159807 IC50 676.0 nM
CCCCCCCCCCCCC/C(=N\O)c1cc(-c2ccc(O)c(F)c2)ccc1O CHEMBL4293423 IC50 680.0 nM
CCCCCCCCCCC/C(=N\O)c1cc(-c2ccc(O)c(F)c2)ccc1O CHEMBL4284088 IC50 710.0 nM
COc1ccc(N2CCN(C(=O)c3ccc4nc(N5CCC(C)CC5)sc4c3)CC2)cc1 CHEMBL1356127 Kd 710.0 nM
C/C(=N/NC(=O)Nc1ccc(S(C)(=O)=O)cc1)c1ccc(O)cc1 CHEMBL5193249 IC50 730.0 nM
S=C(SSC(=S)N1CCCc2ccccc21)N1CCCc2ccccc21 CHEMBL570340 pIC50 741.31 nM
CN(C(=S)SSC(=S)N(C)c1ccccc1)c1ccccc1 CHEMBL570804 pIC50 741.31 nM
O=S(=O)(F)CCCCCCCc1cccc(OCc2ccccc2)c1 CHEMBL2180831 IC50 752.1 nM
O=C(c1ccc(Nc2ccccc2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4753531 IC50 758.0 nM
O=C(/C=C/c1ccc(-c2ccccc2)cc1)OCC1CCCCO1 CHEMBL2011319 pI50 758.58 nM
CCCCc1ccc(S(=O)(=O)N2CCN(C(=O)Oc3ccc([N+](=O)[O-])cc3)CC2)cc1 CHEMBL5200684 IC50 759.0 nM
CCCCCCCCCCCCC/C(=N\O)c1cc(-c2ccc(O)cc2)ccc1O CHEMBL4282758 IC50 770.0 nM
O=C(CN1CCOCC1)Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL4785038 IC50 780.0 nM
O=C1C=CC(=O)N1Cc1ccc(-c2ccccc2)cc1 CHEMBL576859 IC50 790.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C2/C(=O)Nc3ccc(Cl)cc32)cc1 CHEMBL5206035 IC50 790.0 nM
CC(=O)c1cccc(-c2ccc(Cc3nnn(C(=O)N(C)C)n3)cc2)c1 CHEMBL2376845 IC50 807.4 nM
O=C(c1cc(-c2ccc(O)cc2)n(Cc2ccccc2)n1)N1CCC(Cc2ccccc2)CC1 CHEMBL4098069 IC50 810.0 nM
S=C(SSC(=S)N1CCCCCC1)N1CCCCCC1 CHEMBL585179 pIC50 812.83 nM
CC(c1ccccc1)N1CCN(C(=S)Sc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])CC1 CHEMBL2158986 pIC50 812.83 nM
CN1CCN(CC(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)CC1 CHEMBL4800406 IC50 815.0 nM
O=[N+]([O-])c1ccc(SC(=S)N2CCC(Cc3ccccc3)CC2)c([N+](=O)[O-])c1 CHEMBL2158984 pIC50 831.76 nM
O=C(c1cccc(O)c1)N1CCC(Cc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)CC1 CHEMBL5197550 IC50 866.7 nM
CCN(CC)C(=O)n1nnc(-c2ccc(Oc3ccccc3)cc2)n1 CHEMBL2376204 IC50 870.0 nM
CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC=O CHEMBL458827 IC50 890.0 nM
O=C(O[C@@H](CO)C(F)(F)F)N1C[C@@H]2[C@H](C1)[C@H]2c1ccn(-c2ccc(F)cc2)n1 CHEMBL4089392 IC50 890.0 nM
O=C1CC[C@]2(C[C@@H](C(=O)N3CCC(COc4ccc(F)cc4Cl)CC3)C2)N1 CHEMBL4864582 IC50 890.0 nM
CCCCCCCCCCCCCCC/C(=N\O)c1cc(-c2ccc(O)c(F)c2)ccc1O CHEMBL4283120 IC50 910.0 nM
S=C(SSC(=S)N1CCCC1)N1CCCC1 CHEMBL583959 pIC50 912.01 nM
COc1ccccc1NC(=O)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4640805 IC50 926.3 nM
CCCCCCCC/C=C\CCCCCCCCN1C(=O)C=CC1=O CHEMBL566336 IC50 930.0 nM
O=C(c1ccc(N2CCN(C(=O)n3nnc4ccccc43)CC2)c([N+](=O)[O-])c1)N1CCOCC1 CHEMBL2159786 IC50 955.0 nM
CCCCCCCCCCCCCCC/C(=N\O)c1cc(-c2ccc(O)cc2)ccc1O CHEMBL4293367 IC50 960.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2cc(O)ccc2Cl)CC1 CHEMBL4468362 IC50 960.0 nM
O=C(Oc1ccccc1)N1CCN(C(c2ccccc2)c2ccccc2)CC1 CHEMBL4471226 IC50 965.0 nM
CN(C)C(=S)SSC(=S)N(C)C CHEMBL120563 pIC50 977.24 nM
O=[N+]([O-])c1ccc(SC(=S)N2CCN(C/C=C/c3ccccc3)CC2)c([N+](=O)[O-])c1 CHEMBL2158985 pIC50 977.24 nM
O=C(c1ccccc1)N1CCN(C2CN(C(=O)c3ccc4c(ccn4-c4nccc(F)n4)c3)C2)CC1 CHEMBL4644784 IC50 979.0 nM
CCCCCCCCCCCCNC(=O)Oc1ccc(-c2csnn2)cc1 CHEMBL569368 IC50 1000.0 nM
O=[N+]([O-])c1ccc(SC(=S)N2CCN(Cc3ccccc3)CC2)c([N+](=O)[O-])c1 CHEMBL2158983 pIC50 1000.0 nM
CCCCCCCCC/C(=N\O)c1cc(-c2ccc(O)c(F)c2)ccc1O CHEMBL4291956 IC50 1000.0 nM
N#Cc1cccc(OC(=O)N2CCC(S(=O)(=O)C(c3ccccc3)c3ccccc3)CC2)c1 CHEMBL4476489 IC50 1000.0 nM
O=C(c1ccc2c(c1)OCCO2)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4542020 IC50 1000.0 nM
O=C(c1ccc(-c2cn(-c3ccccc3)nn2)cc1)C1CCN(C(=O)c2cccc(O)c2)CC1 CHEMBL4784401 IC50 1000.0 nM
CS(=O)(=O)c1ccc(NC(=O)N/N=C\c2ccccc2)cc1 CHEMBL5169361 IC50 1000.0 nM