Nc1cc(Nc2cc(Cl)c3n(c2=O)C2(CCCC2)NC3=O)ncn1 CHEMBL4094975 IC50 0.13 nM
CC1(C)NC(=O)c2c(Cl)cc(Nc3cc(N)ncn3)c(=O)n21 CHEMBL4067557 IC50 0.14 nM
Nc1ncnc(Nc2cc(Cl)c3n(c2=O)C2(CCCCC2)NC3=O)c1Cl CHEMBL4086747 IC50 0.36 nM
Nc1cc(Nc2cc(Cl)c3n(c2=O)C2(CCCCC2)NC3=O)ncn1 CHEMBL4076439 IC50 0.68 nM
C[C@H]1CN(c2cccc3nc(-c4nc(-c5cccc(C(=O)N(C)C)c5)cnc4N)n(C)c23)CCN1 CHEMBL3797873 IC50 0.7 nM
CN(C)C(=O)c1cccc(-c2cnc(N)c(-c3nc4cccc(N5CCNCC5)c4n3C)n2)c1 CHEMBL3798762 IC50 1.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(F)(F)F CHEMBL4111493 IC50 1.0 nM
Cc1cc([C@@H](C)Oc2ncccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(Cl)c23)on1 CHEMBL4113944 IC50 1.0 nM
Cc1cc([C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(Cl)c23)on1 CHEMBL4109804 IC50 1.0 nM
O=S1(=Nc2cc(C(F)(F)F)c3c(Nc4ccc(F)cc4OC(CF)CF)ncnc3c2)CCOCC1 CHEMBL3969508 IC50 1.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3cccnc3OCC3CCOC3)c12 CHEMBL3916533 IC50 1.0 nM
Cc1cc([C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)on1 CHEMBL4112682 IC50 1.0 nM
Cc1cc([C@@H](C)Oc2ncccc2Nc2ncnc3cc(N=S4(=O)CCCC4)cc(C)c23)on1 CHEMBL4112720 IC50 1.0 nM
Cc1cc([C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S4(=O)CCNCC4)cc(C)c23)on1 CHEMBL4106829 IC50 1.0 nM
Cc1cc([C@@H](C)Oc2ncccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)on1 CHEMBL4111586 IC50 1.0 nM
Cc1cc(N=S2(=O)CC[C@H](N)C2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4110377 IC50 1.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CC(C)(C)C3)cc(F)c12)C(=O)NCC#N CHEMBL4114582 IC50 1.0 nM
COC(=O)N1CC2(C1)CS(=O)(=Nc1cc(C)c3c(Nc4ccc(F)cc4O[C@H](C)C(=O)NCC(F)(F)F)ncnc3c1)C2 CHEMBL4107908 IC50 1.0 nM
Cc1cc(N=S2(=O)CC(C)(C)C2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4111078 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(C(F)(F)F)C(F)(F)F)c12 CHEMBL4108347 IC50 1.0 nM
Cc1cc(N=S2(=O)CC(C)(C)C2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4110758 IC50 1.0 nM
Cc1cc(N=S2(=O)CC3(COC3)C2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4108416 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC#N)c12 CHEMBL3963888 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3CCCCO3)c12 CHEMBL3926461 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)CN)c12 CHEMBL4114923 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCc3ccon3)c12 CHEMBL3904562 IC50 1.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(F)c12)C(=O)NCC(F)(F)F CHEMBL4112632 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(C(F)(F)F)C(F)(F)F)c12 CHEMBL4107951 IC50 1.0 nM
C#CCNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4108049 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)F)c12 CHEMBL4111906 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC#N)c12 CHEMBL4110019 IC50 1.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(C)C)c12 CHEMBL4109353 IC50 1.0 nM
CCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4111615 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4115507 IC50 1.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4109890 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4111236 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCCC(F)(F)F)c12 CHEMBL4106658 IC50 1.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(Cl)c12)C(=O)N[C@H](C)C(F)(F)F CHEMBL4110073 IC50 1.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(=O)NCC(F)(F)F CHEMBL4115641 IC50 1.0 nM
C[C@@H](C#N)NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(F)c12 CHEMBL3901822 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)nc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4109192 IC50 1.0 nM
C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(Cl)c12)C(F)(F)F CHEMBL4114373 IC50 1.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(=O)NCC#N CHEMBL4113129 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC#N)c12 CHEMBL4115452 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4110194 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)F)c12 CHEMBL4109416 IC50 1.0 nM
C[C@H](C#N)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12 CHEMBL4113301 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4113339 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)nc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4107227 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NC(C)C(F)F)c12 CHEMBL4113652 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(CF)CF)c12 CHEMBL4108126 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(C)C#N)c12 CHEMBL4107329 IC50 1.0 nM
C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(F)(F)F CHEMBL4112904 IC50 1.0 nM
C[C@@H](C#N)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(Cl)c12 CHEMBL3958645 IC50 1.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(Cl)c12)C(=O)NCC(F)(F)F CHEMBL4115007 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4113440 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)nc3O[C@H](C)C(=O)N[C@@H](C)C#N)c12 CHEMBL3903763 IC50 1.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)F)c12 CHEMBL4110107 IC50 1.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@@H](C)CNS(C)(=O)=O)c12 CHEMBL3957458 IC50 1.0 nM
Cc1cc([C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S4(=O)CCN(C)CC4)cc(C)c23)on1 CHEMBL4108210 IC50 1.0 nM
Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4073443 IC50 1.0 nM
Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCC(F)(F)CC1 CHEMBL4065802 IC50 1.0 nM
Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4298140 IC50 1.0 nM
CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n21 CHEMBL4084102 IC50 1.2 nM
CC1(c2cccc(Cl)c2)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21 CHEMBL4064839 IC50 1.2 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 1.4 nM
O=C1NC2(CCCCC2)n2c1c(Cl)cc(Nc1ccncn1)c2=O CHEMBL4439094 IC50 1.5 nM
O=C(c1ccc(-c2ccc3ncc(-c4ccc5cnccc5c4)n3c2)cc1)N1CCC(N2CCCCC2)CC1 CHEMBL4858035 IC50 1.5 nM
O=C1NC2(CCCCC2)n2c1c(Cl)cc(Nc1cc(NC(=O)C3CC3)ncn1)c2=O CHEMBL4073743 IC50 1.8 nM
CN(C)CCCNC(=O)c1nc2c(N3CCc4cc(F)ccc43)ncnc2s1 CHEMBL5181488 pIC50 1.995 nM
CN(C)C(=O)c1cccc(-c2cnc(N)c(-c3nc4cccc(N5CCNCC5)c4[nH]3)c2)c1 CHEMBL3797828 IC50 2.0 nM
CCS(C)(=O)=Nc1cc(Cl)c2c(Nc3cccnc3O[C@H](C)c3cc(C)no3)ncnc2c1 CHEMBL4111558 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3982761 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)C(F)(F)F)c12 CHEMBL3890297 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)c12 CHEMBL4108118 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)C)c12 CHEMBL3919671 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3cccnc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4110633 IC50 2.0 nM
Cc1cc([C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S4(=O)CCCC4)cc(Cl)c23)on1 CHEMBL4114535 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3896211 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3cccnc3O[C@H](C)C(=O)NCC(F)F)c12 CHEMBL4111326 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3cccnc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4107072 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC(O)C2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4110871 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC(C)C2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4111680 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CC(C)(C)C3)cc(Cl)c12)C(=O)NCC(F)(F)F CHEMBL4111260 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](CO)C(F)(F)F)c12 CHEMBL4109919 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)c12 CHEMBL4106460 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3966399 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC[C@H]3CNC(=O)O3)c12 CHEMBL4112877 IC50 2.0 nM
COc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4109958 IC50 2.0 nM
C#CC(C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL3943178 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)c3ccccn3)c12 CHEMBL3973876 IC50 2.0 nM
CCOC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4108793 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3(C(F)(F)F)CC3)c12 CHEMBL3917357 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3CCNC(=O)C3)c12 CHEMBL3934970 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC[C@H]3CCC(=O)N3)c12 CHEMBL4109732 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)c3ccncc3)c12 CHEMBL3959276 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(=O)NCC(F)(F)F CHEMBL4113312 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(CC(F)F)CC(F)F)c12 CHEMBL4110842 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)C(C)C)c12 CHEMBL4108318 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC#N)c12 CHEMBL4113574 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(C)O)c12 CHEMBL4113557 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC3COC3)c12 CHEMBL4108342 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC3CCC3)c12 CHEMBL4112581 IC50 2.0 nM
CCCNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4113233 IC50 2.0 nM
COCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4110707 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)F)c12 CHEMBL4114128 IC50 2.0 nM
CCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4112395 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@H]3CCOC3)c12 CHEMBL4110477 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(C)C)c12 CHEMBL4112522 IC50 2.0 nM
C[C@@H](C#N)NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12 CHEMBL3967951 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(=O)NCCF CHEMBL4110710 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(=O)NCC(F)F CHEMBL4107688 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(C)C)c12 CHEMBL4111438 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC34CC(C3)C4)c12 CHEMBL4114152 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C3CC3)c12)C(=O)NCC(F)(F)F CHEMBL4113841 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(=O)NCC#N CHEMBL4111795 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C(F)(F)F)c12)C(=O)NCC(F)(F)F CHEMBL4115093 IC50 2.0 nM
COc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4107782 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4115037 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4110252 IC50 2.0 nM
CCOc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)N[C@@H](C)C#N)c12 CHEMBL3959814 IC50 2.0 nM
CC(C#N)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12 CHEMBL4109535 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(=O)NCC(F)(F)F CHEMBL4107950 IC50 2.0 nM
C[C@@H](C#N)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(C(F)F)c12 CHEMBL3951911 IC50 2.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCCF)c12 CHEMBL4109489 IC50 2.0 nM
C[C@@H](C#N)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12 CHEMBL3910881 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCCF)c12 CHEMBL4108376 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(C)C(F)F)c12 CHEMBL4108185 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(C(F)F)c12)C(=O)NCC(F)(F)F CHEMBL4106850 IC50 2.0 nM
C[C@H](C#N)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(Cl)c12 CHEMBL4109879 IC50 2.0 nM
COc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC#N)c12 CHEMBL4109753 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCCC(F)F)c12 CHEMBL4109513 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)C(F)(F)F)c12 CHEMBL4111298 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(=O)NC(CF)CF CHEMBL4110031 IC50 2.0 nM
CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(Cl)c12)C(F)F CHEMBL4106912 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4110927 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(=O)NC(CF)CF CHEMBL4112893 IC50 2.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(=O)NCC(F)(F)C(F)(F)F CHEMBL4111932 IC50 2.0 nM
C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(F)(F)F CHEMBL4113746 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)F)c12 CHEMBL4112349 IC50 2.0 nM
C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(C(F)F)c12)C(F)(F)F CHEMBL4109482 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCCCF)c12 CHEMBL4112873 IC50 2.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)N[C@H](C)C(F)(F)F)c12 CHEMBL4107518 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@@H](C)CNC(=O)C(F)(F)F)c12 CHEMBL3953860 IC50 2.0 nM
CC(=O)N1CCS(=O)(=Nc2cc(C)c3c(Nc4ccc(F)cc4O[C@H](C)c4cc(C)no4)ncnc3c2)CC1 CHEMBL4107369 IC50 2.0 nM
CCNC(=O)N1CCS(=O)(=Nc2cc(C)c3c(Nc4ccc(F)cc4O[C@H](C)c4cc(C)no4)ncnc3c2)CC1 CHEMBL4108901 IC50 2.0 nM
COC(=O)N1CCS(=O)(=Nc2cc(C)c3c(Nc4ccc(F)cc4O[C@H](C)c4cc(C)no4)ncnc3c2)CC1 CHEMBL4115668 IC50 2.0 nM
COc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)F)c12 CHEMBL4113626 IC50 2.0 nM
COc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)c3cc(C)no3)c12 CHEMBL3967260 IC50 2.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)c12 CHEMBL4112179 IC50 2.0 nM
CC1(C)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21 CHEMBL4086319 IC50 2.3 nM
N[C@H]1CCCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc6cnccc6c5)n4c3)cc2)C1 CHEMBL4857770 IC50 2.5 nM
CC1(C)CN(c2ncnc3sc(C(=O)NCC4CCNCC4)nc23)c2ccccc21 CHEMBL5183975 pIC50 2.512 nM
CC1(C)NC(=O)c2c(F)cc(Nc3ccncn3)c(=O)n21 CHEMBL4091862 IC50 2.6 nM
O=C(c1ccc(-c2ccc3ncc(-c4ccc5cnccc5c4)n3c2)cc1)N1CCNCC1 CHEMBL4865340 IC50 2.9 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 3.0 nM
C[C@H]1CN(c2cccc3nc(-c4nc(-c5cc(C(=O)N(C)C)ccn5)cnc4N)n(C)c23)CCN1 CHEMBL3800585 IC50 3.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3702343 IC50 3.0 nM
O=S1(=Nc2cc(C(F)(F)F)c3c(Nc4ccc(F)cc4OC(CF)CF)ncnc3c2)CCCC1 CHEMBL3982214 IC50 3.0 nM
CS(C)(=O)=Nc1cc(C2CC2)c2c(Nc3ccc(F)cc3OC(CF)CF)ncnc2c1 CHEMBL3943394 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3OC(C)C(C)(C)C#N)c12 CHEMBL3907569 IC50 3.0 nM
Cc1cc(N=S2(=O)CC[C@@H](N)C2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4113160 IC50 3.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CC4(COC4)C3)cc(Cl)c12)C(=O)NCC(F)(F)F CHEMBL4112916 IC50 3.0 nM
Cc1cc(N=S(C)(=O)C2CCNC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4111599 IC50 3.0 nM
Cc1cc(N=S2(=O)CC3(COC3)C2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4112352 IC50 3.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3cccnc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4109407 IC50 3.0 nM
Cc1cc(N=S(C)(=O)C(C)C)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4112086 IC50 3.0 nM
COc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4110142 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)Cn3ccnc3C)c12 CHEMBL3951454 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3CNC(=O)C3)c12 CHEMBL3978485 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@H](C)C(F)(F)F)c12 CHEMBL4107454 IC50 3.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(CC(F)(F)F)CC(F)(F)F)c12 CHEMBL4111443 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(CC(F)(F)F)CC(F)(F)F)c12 CHEMBL4107921 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC3CCOCC3)c12 CHEMBL4110430 IC50 3.0 nM
CNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4108264 IC50 3.0 nM
CCN(CC)C(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4108389 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)C3CCCC3)c12 CHEMBL4111539 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCCO)c12 CHEMBL4106820 IC50 3.0 nM
CCNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4115253 IC50 3.0 nM
CC#CCNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4111309 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@H]3CCOC3)c12 CHEMBL4112213 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)CC(C)C)c12 CHEMBL4112011 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(C)(C)O)c12 CHEMBL4108589 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCCCC3)c12 CHEMBL4110518 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCCO)c12 CHEMBL4107930 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC(CF)CF)c12 CHEMBL4109059 IC50 3.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(=O)NCCF CHEMBL4114969 IC50 3.0 nM
C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(F)(F)F CHEMBL4110890 IC50 3.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(=O)NCC(F)F CHEMBL4115409 IC50 3.0 nM
CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12)C(F)F CHEMBL4112102 IC50 3.0 nM
CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12)C(F)F CHEMBL4110023 IC50 3.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(Cl)cc3O[C@H](C)C(=O)N[C@@H](C)C#N)c12 CHEMBL3939796 IC50 3.0 nM
COc1cc(N=S(C)(C)=O)cc2ncnc(Nc3cccnc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4111519 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)C#N)c12 CHEMBL3946482 IC50 3.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(F)(F)F CHEMBL4111983 IC50 3.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3OC(C)C#N)c12 CHEMBL3950875 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C#N)c12 CHEMBL4113835 IC50 3.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](CO)C(=O)NCC(F)(F)F)c12 CHEMBL4114025 IC50 3.0 nM
O=C(NCC1CCNCC1)c1nc2c(N3CCc4cc(Cl)ccc43)ncnc2s1 CHEMBL5180948 pIC50 3.162 nM
O=C(c1ccc(-c2ccc3ncc(-c4ccc5cnccc5c4)n3c2)cc1)N1CCC(N2CCOCC2)CC1 CHEMBL4864827 IC50 3.2 nM
N[C@H]1CCCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc6cnccc6c5)n4n3)cc2)C1 CHEMBL4878199 IC50 3.4 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 3.7 nM
CN(C)CCCNC(=O)c1nc2c(N3CC(C)(C)c4ccccc43)ncnc2s1 CHEMBL5206647 pIC50 3.981 nM
O=C(NCC1CCNCC1)c1nc2c(N3CCc4cc(F)ccc43)ncnc2s1 CHEMBL5203720 pIC50 3.981 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3698956 IC50 4.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C CHEMBL3632739 IC50 4.0 nM
Cc1cc(N=S(C)(=O)C2CCOCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4112566 IC50 4.0 nM
COc1cc(N=S(C)(=O)C2CC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4107133 IC50 4.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(F)c12)C(=O)NCC#N CHEMBL4112361 IC50 4.0 nM
Cc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](CO)CF)c12 CHEMBL3956958 IC50 4.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC(=O)N(C)C)c12 CHEMBL3987201 IC50 4.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCC(O)C3)c12 CHEMBL4114613 IC50 4.0 nM
C#CCNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4108106 IC50 4.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(C)O)c12 CHEMBL4115343 IC50 4.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)CCO)c12 CHEMBL4108646 IC50 4.0 nM
COC1CCN(C(=O)[C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S4(=O)CCCC4)cc(C)c23)CC1 CHEMBL4114622 IC50 4.0 nM
CCN(C)C(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4115255 IC50 4.0 nM
CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(Cl)c12 CHEMBL4113568 IC50 4.0 nM
COc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)c12 CHEMBL4115407 IC50 4.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(=O)NCC(F)F CHEMBL4106616 IC50 4.0 nM
CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(C(F)F)c12)C(F)F CHEMBL4111658 IC50 4.0 nM
COCC(=O)N1CCS(=O)(=Nc2cc(C)c3c(Nc4ccc(F)cc4O[C@H](C)c4cc(C)no4)ncnc3c2)CC1 CHEMBL4109457 IC50 4.0 nM
CCOc1cc(N=S2(=O)CCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4111516 IC50 4.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](CF)C(=O)NCC(F)(F)F)c12 CHEMBL4113970 IC50 4.0 nM
Nc1n[nH]c2cc(-c3ccc(=O)n(Cc4ccccc4F)c3)ccc12 CHEMBL4752141 IC50 4.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3702322 IC50 5.0 nM
CC(CF)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12 CHEMBL3893219 IC50 5.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(C(N)=O)cc3OC(C)C)c12 CHEMBL3921876 IC50 5.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3OC(C)C(C)(C)O)c12 CHEMBL3930942 IC50 5.0 nM
Cc1cc(N=S(C)(=O)C2CC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4113168 IC50 5.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12 CHEMBL3942070 IC50 5.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCCC(F)(F)F)c12 CHEMBL3940502 IC50 5.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC[C@@H]3CCC(=O)N3)c12 CHEMBL3899161 IC50 5.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC3CCCO3)c12 CHEMBL4112569 IC50 5.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)C)c12 CHEMBL4110356 IC50 5.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCCC3)c12 CHEMBL4109589 IC50 5.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)CC(C)C)c12 CHEMBL4114069 IC50 5.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC3CCC3)c12 CHEMBL4115334 IC50 5.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(N)=O)c12 CHEMBL4108717 IC50 5.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)C)c12 CHEMBL4108125 IC50 5.0 nM
CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)cc(F)c12 CHEMBL4113595 IC50 5.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(=O)NC(CF)CF CHEMBL4111102 IC50 5.0 nM
Nc1n[nH]c2cc(-c3ccc(=O)n(Cc4cccc(F)c4)c3)ccc12 CHEMBL4787269 IC50 5.0 nM
Nc1n[nH]c2cc(-c3ccc(=O)n(Cc4cccc(Cl)c4)c3)cc(NCC3CCOCC3)c12 CHEMBL5196282 IC50 5.0 nM
CC(=O)N1CCC(CNc2cc(-c3ccc(=O)n(Cc4cccc(Cl)c4)c3)cc3[nH]nc(N)c23)CC1 CHEMBL5204789 IC50 5.0 nM
NC1CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc6cnccc6c5)n4c3)cc2)CC1 CHEMBL4872637 IC50 5.2 nM
CC1CCCCN1C(=O)c1ccc(-c2nn3c(-c4ccc(C#N)cc4)cnc3s2)cc1 CHEMBL5279032 IC50 5.33 nM
Nc1n[nH]c2cc(-c3ccc(=O)n(Cc4cccc(Cl)c4)c3)ccc12 CHEMBL4764756 IC50 5.4 nM
O=C1NCc2cc(Nc3cc(NC(=O)C4CC4)ncn3)ccc21 CHEMBL4100554 IC50 5.7 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(C)C)c12 CHEMBL3659491 IC50 6.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3698955 IC50 6.0 nM
Cc1c(C(=O)NCCCN2CCCC2)sc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3702328 IC50 6.0 nM
CS(C)(=O)=Nc1cc(C(F)(F)F)c2c(Nc3ccc(F)cc3OC(CF)CF)ncnc2c1 CHEMBL3977414 IC50 6.0 nM
Cc1cc(C(C)Oc2cc(C(N)=O)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)on1 CHEMBL3932256 IC50 6.0 nM
CS(C)(=O)=Nc1cc(F)c2c(Nc3ccc(F)cc3OC(CF)CF)ncnc2c1 CHEMBL3936235 IC50 6.0 nM
Cc1cc(C(C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(F)c23)on1 CHEMBL3953178 IC50 6.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3OCc3ccccc3)c12 CHEMBL3944472 IC50 6.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)COC3CCOC3)c12 CHEMBL3901964 IC50 6.0 nM
COc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c12 CHEMBL4111024 IC50 6.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CC[S+]([O-])CC3)c12 CHEMBL4114913 IC50 6.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NC3CCOCC3)c12 CHEMBL4115240 IC50 6.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(C)(C)O)c12 CHEMBL4110716 IC50 6.0 nM
Cc1cc(Nc2cc(N3CCN(CCCN(C)C)CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4757546 IC50 6.1 nM
N[C@@H]1CCCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc6cnccc6c5)n4n3)cc2)C1 CHEMBL4862069 IC50 6.6 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3702341 IC50 7.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3702342 IC50 7.0 nM
Cc1c(C(=O)NCC#CCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3702250 IC50 7.0 nM
Cc1c(C(=O)NCCCN2CCCC2)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3702251 IC50 7.0 nM
Cc1c(C(=O)NS(C)(=O)=O)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3702252 IC50 7.0 nM
Cc1c(C(=O)NCC#N)sc2ncnc(Nc3ccc(C#N)cc3OC(CF)CF)c12 CHEMBL3702309 IC50 7.0 nM
CC(Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(F)(F)F CHEMBL3905069 IC50 7.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(=O)C3CCOCC3)cc(F)c12)C(=O)NCC(F)(F)F CHEMBL4106897 IC50 7.0 nM
Cc1cc(COc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)no1 CHEMBL3973786 IC50 7.0 nM
COCCN(C)C(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4109134 IC50 7.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCC3)c12 CHEMBL4106493 IC50 7.0 nM
CC(=O)NC[C@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL3945124 IC50 7.0 nM
CC(C)Oc1cc(F)ccc1Nc1ncnc2ccc(-c3ccc(C(=O)N4CCNCC4)cc3)nc12 CHEMBL4869634 IC50 7.0 nM
Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1 CHEMBL3545307 IC50 7.0 nM
Cc1cc(Nc2cc(N3CCN(CCN(C)C)CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4796087 IC50 7.5 nM
N[C@H]1C[C@H](Oc2ccc3ncc(-c4ccc5cnccc5c4)n3n2)C1 CHEMBL4094080 IC50 7.8 nM
CN(C)CCCNC(=O)c1nc2c(N3CCc4ccccc43)ncnc2s1 CHEMBL5171562 pIC50 7.943 nM
O=C(CNc1ccc(-c2ccc(NC(=O)C3CC3)nc2)cc1)Nc1ccc(CN2CCNCC2)c(C(F)(F)F)c1 CHEMBL3805330 IC50 8.0 nM
CCN1CCN(Cc2ccc(NC(=O)Cc3ccc(Oc4ccnc(NC)c4)cc3)cc2C(F)(F)F)CC1 CHEMBL3804952 IC50 8.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12 CHEMBL3702337 IC50 8.0 nM
COCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 CHEMBL3702352 IC50 8.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OC(C)CCN)c12 CHEMBL3698937 IC50 8.0 nM
CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C CHEMBL3698957 IC50 8.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3702249 IC50 8.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12 CHEMBL3702320 IC50 8.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(C#N)cc3OC(CF)CF)c12 CHEMBL3702305 IC50 8.0 nM
CC(Oc1ncccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(F)(F)F CHEMBL3957816 IC50 8.0 nM
CCOC(Oc1ncccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12)C(F)(F)F CHEMBL3933795 IC50 8.0 nM
CCOC(Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12)C(F)(F)F CHEMBL3958457 IC50 8.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)c3ncco3)c12 CHEMBL3933086 IC50 8.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3CCO3)c12 CHEMBL3909270 IC50 8.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3(C#N)CCC3)c12 CHEMBL3933675 IC50 8.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCCCO)c12 CHEMBL3908621 IC50 8.0 nM
CCN(CC)C(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4114567 IC50 8.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)C(C)C)c12 CHEMBL4107729 IC50 8.0 nM
CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(F)F CHEMBL4106778 IC50 8.0 nM
CC(=O)Nc1cccc(Cn2cc(-c3ccc4c(N)n[nH]c4c3)ccc2=O)c1 CHEMBL4785028 IC50 8.0 nM
Nc1n[nH]c2cc(-c3ccc(=O)n(Cc4cccc(Cl)c4)c3)cc(OCC3CCOCC3)c12 CHEMBL5176495 IC50 8.0 nM
Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4780209 IC50 8.3 nM
CN1CCN(C(=O)c2ccc(-c3nn4c(-c5ccc(C#N)cc5)cnc4s3)cc2)CC1 CHEMBL5271233 IC50 8.6 nM
N#Cc1ccc(-c2cnc3sc(-c4ccc(C(=O)NCCO)cc4)nn23)cc1 CHEMBL5286963 IC50 8.81 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 8.85 nM
N[C@@H]1CCCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc6cnccc6c5)n4c3)cc2)C1 CHEMBL4852274 IC50 8.9 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)c3cccnc3)c12 CHEMBL3971651 IC50 9.0 nM
Cc1noc(C(C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)n1 CHEMBL3917005 IC50 9.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)Cc3ccccc3)c12 CHEMBL4115270 IC50 9.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCC(=O)CC3)c12 CHEMBL4114235 IC50 9.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H]3CCC[C@H]3O)c12 CHEMBL4106486 IC50 9.0 nM
CC#CCNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4107564 IC50 9.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H]3CCC[C@@H]3O)c12 CHEMBL4107926 IC50 9.0 nM
N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)cc4)cn23)cc1 CHEMBL4211649 IC50 9.4 nM
FC(F)(F)c1ccccc1CNc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1999153 pKi 10.0 nM
CN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(=O)C5CC5)nc4)cc3F)cc2C(F)(F)F)CC1 CHEMBL3806189 IC50 10.0 nM
CCN1CCN(Cc2ccc(NC(=O)Cc3ccc(Oc4ccncc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805114 IC50 10.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3698959 IC50 10.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(C#N)cc3OC(CF)CF)c12 CHEMBL3702307 IC50 10.0 nM
C[C@@H](Oc1ncccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12)C(=O)NCC(F)(F)F CHEMBL4112410 IC50 10.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3CCOCC3)c12 CHEMBL3893800 IC50 10.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N=S(C)(C)=O)c12 CHEMBL4108469 IC50 10.0 nM
Cc1cc(N=S2(=O)CCCC2)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)CCc3ccccc3)c12 CHEMBL4108445 IC50 10.0 nM
O=C(c1ccc(-c2ccc3ncnc(Nc4ccccc4F)c3n2)cc1)N1CCNCC1 CHEMBL4872538 IC50 10.0 nM
N#Cc1ccc(-c2cnc3sc(-c4ccc(C(=O)NCCN5CCCC5)cc4)nn23)cc1 CHEMBL5280197 IC50 10.4 nM
CC(=O)C1=C(O)C=C2Oc3c(C(N)=O)c(O)cc(O)c3[C@@]2(C)C1=O CHEMBL3416305 IC50 11.0 nM
CCN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4cccnc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3806261 IC50 11.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c12 CHEMBL3698947 IC50 11.0 nM
CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 CHEMBL3702269 IC50 11.0 nM
Cc1c(C(=O)NC2CCN(C)CC2)sc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3702329 IC50 11.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(C)C#N)c12 CHEMBL3702310 IC50 11.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)C(C)(C)C#N)c12 CHEMBL3947467 IC50 11.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3CCOC3)c12 CHEMBL3954028 IC50 11.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CC[S+]([O-])CC3)c12 CHEMBL4111881 IC50 11.0 nM
CN(C)C1CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4n3)cc2)CC1 CHEMBL4216109 IC50 11.0 nM
O=C(COc1ccc(-c2cccnc2)cc1)Nc1ccc(CN2CCNCC2)c(C(F)(F)F)c1 CHEMBL3805029 IC50 12.0 nM
Cc1c(C(=O)NCCCN2CCCC2)sc2ncnc(Nc3ccc(F)cc3OC(C)CC(F)(F)F)c12 CHEMBL3702356 IC50 12.0 nM
CNC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c2c1C CHEMBL3698950 IC50 12.0 nM
Cc1c(C(=O)N[C@@H]2C[C@H]2N)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3702253 IC50 12.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OCC(C)F)c12 CHEMBL3702326 IC50 12.0 nM
Cc1c(C(=O)NCCC2CCN(C)C2)sc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3702327 IC50 12.0 nM
COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C CHEMBL3702277 IC50 12.0 nM
Cc1c(C(=O)NCCCN2CCCC2)sc2ncnc(Nc3ccc(C#N)cc3OC(CF)CF)c12 CHEMBL3702304 IC50 12.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c12 CHEMBL3911848 IC50 12.0 nM
COCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4106776 IC50 12.0 nM
O=c1ccc(-c2n[nH]c3ncc(Br)cc23)cn1Cc1ccccc1 CHEMBL4743561 IC50 12.0 nM
CN(C)CCCNC(=O)c1cc2ncnc(N3CCc4cc(F)ccc43)c2n1C CHEMBL5196084 pIC50 12.59 nM
COCC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12 CHEMBL3702339 IC50 13.0 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 IC50 13.0 nM
Cc1c(C(=O)N[C@@H]2C[C@H]2NC(=O)OC(C)(C)C)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3698958 IC50 13.0 nM
CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NC)c(C)c12 CHEMBL3702270 IC50 13.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OCC(F)F)c12 CHEMBL3702319 IC50 13.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OCCO)c12 CHEMBL3702323 IC50 13.0 nM
Cc1c(C(=O)NC2CCN(C)CC2)sc2ncnc(Nc3ccc(C#N)cc3OC(CF)CF)c12 CHEMBL3702306 IC50 13.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)C(C)(C)O)c12 CHEMBL3922022 IC50 13.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)CCO)c12 CHEMBL4112710 IC50 13.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCCCC3)c12 CHEMBL4108396 IC50 13.0 nM
COC1CCN(C(=O)[C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)CC1 CHEMBL4114099 IC50 13.0 nM
CCN1CCN(Cc2ccc(NC(=O)COc3ccc(-c4cccnc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805956 IC50 14.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OC(C)CN)c12 CHEMBL3698925 IC50 14.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OCCC(F)(F)F)c12 CHEMBL3702325 IC50 14.0 nM
Cc1c(C(=O)NCC#CCN)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702296 IC50 14.0 nM
COCCN(C)C(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4110402 IC50 14.0 nM
Cc1n[nH]c(C)c1-c1cncc(-c2ccc(C(N)=O)c(OC(C)C)c2)c1 CHEMBL4442209 IC50 14.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c12 CHEMBL3698946 IC50 15.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OCC3CC3(F)F)c12 CHEMBL3702276 IC50 15.0 nM
CCC(C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL3981737 IC50 15.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCC(=O)CC3)c12 CHEMBL4108141 IC50 15.0 nM
NC1CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc6cnccc6c5)n4n3)cc2)CC1 CHEMBL4862651 IC50 15.7 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 15.85 nM
CCN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(=O)C5CC5)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805771 IC50 16.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OCC(F)F)c12 CHEMBL3702333 IC50 16.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OCC3(CC#N)CC3)c12 CHEMBL3702274 IC50 16.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@@H](C)CN)c12 CHEMBL3919311 IC50 16.0 nM
CCOC(=O)[C@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL3902565 IC50 16.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)C3CCCC3)c12 CHEMBL4110320 IC50 16.0 nM
Cc1[nH]ncc1-c1cncc(-c2ccc(C(N)=O)c(OC(C)C)c2)c1 CHEMBL4569209 IC50 16.0 nM
N#Cc1ccc(-c2cnc3sc(-c4ccc(C(=O)NCCCO)cc4)nn23)cc1 CHEMBL5288682 IC50 16.69 nM
Cc1c(C(=O)NCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 CHEMBL3698960 IC50 17.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(C)C#N)c12 CHEMBL3702317 IC50 17.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(C#N)cc3OC(C)C(F)(F)F)c12 CHEMBL3906775 IC50 17.0 nM
Cc1cc(C(Oc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)C(F)(F)F)on1 CHEMBL3942764 IC50 17.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)Cn3ccnc3)c12 CHEMBL3927638 IC50 17.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3(C)COC3)c12 CHEMBL3936564 IC50 17.0 nM
CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C CHEMBL3632744 Ki 18.0 nM
CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C CHEMBL3632745 Ki 18.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(C)CNS(C)(=O)=O)c12 CHEMBL3698918 IC50 18.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OCC(F)F)c12 CHEMBL3702264 IC50 18.0 nM
COCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)O)c(C)c12 CHEMBL3702324 IC50 18.0 nM
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(=O)C(C)(C)C)cc(F)c12)C(=O)NCC(F)(F)F CHEMBL4113239 IC50 18.0 nM
Cc1cc(Nc2cc(N3CCNCC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4754824 IC50 18.3 nM
NC1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc6cnccc6c5)cnc4cn3)cc2)CC1 CHEMBL4857509 IC50 18.5 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12 CHEMBL3702336 IC50 19.0 nM
CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)O)c(C)c12 CHEMBL3702268 IC50 19.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OCC3(CC#N)CC3)c12 CHEMBL3702318 IC50 19.0 nM
Cc1c(C(=O)NCc2cnco2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702285 IC50 19.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCC3)c12 CHEMBL4110084 IC50 19.0 nM
Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C CHEMBL4062387 IC50 19.0 nM
N[C@H]1CCCN(C(=O)c2ccc(-c3cn4c(-c5ccc6cnccc6c5)cnc4cn3)cc2)C1 CHEMBL4865426 IC50 19.4 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 19.95 nM
CN(C)C(=O)c1cccc(-c2cnc(N)c(-c3nc4cccc(N5CCNCC5)c4[nH]3)n2)c1 CHEMBL3798066 IC50 20.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c12 CHEMBL3698952 IC50 20.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OCC(F)F)c12 CHEMBL3702263 IC50 20.0 nM
CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 CHEMBL3702271 IC50 20.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OC(C)CCNS(C)(=O)=O)c12 CHEMBL3702301 IC50 20.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCCC3)c12 CHEMBL4115005 IC50 20.0 nM
N#Cc1ccc(-c2cnc3sc(-c4ccc(C(=O)N5CCCC5)cc4)nn23)cc1 CHEMBL5288290 IC50 20.83 nM
Nc1n[nH]c2cc(-c3ccc(=O)n(Cc4cccc(C(F)(F)F)c4)c3)ccc12 CHEMBL4757431 IC50 21.0 nM
N#Cc1ccc(-c2cnc3sc(-c4ccc(C(=O)NCCCN5CCOCC5)cc4)nn23)cc1 CHEMBL5270526 IC50 21.6 nM
CCN1CCN(Cc2ccc(NC(=O)Cc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805074 IC50 22.0 nM
Cc1c(C(=O)NCC#CCN(C)C)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702293 IC50 22.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCC(F)F)c12 CHEMBL3702335 IC50 23.0 nM
CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CN)c2c1C CHEMBL3698915 IC50 23.0 nM
COCC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)O)c(C)c12 CHEMBL3702321 IC50 23.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)C3CCCO3)c12 CHEMBL3940893 IC50 23.0 nM
CCOC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)cc(C)c12 CHEMBL4112389 IC50 23.0 nM
Cc1c(C(=O)NCC#CCN(C)C)sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c12 CHEMBL3698951 IC50 24.0 nM
Cc1c(C(=O)NCc2cn(C)cn2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702292 IC50 24.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OC(C)CCNS(C)(=O)=O)c12 CHEMBL3702300 IC50 24.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)CC3CCOCC3)c12 CHEMBL3930273 IC50 24.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC3CCCO3)c12 CHEMBL4114974 IC50 24.0 nM
COCC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 CHEMBL3702340 IC50 25.0 nM
COCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12 CHEMBL3702351 IC50 25.0 nM
Cc1c(C(=O)NC2CCN(C)CC2)sc2ncnc(Nc3ccc(F)cc3OC(C)CC(F)(F)F)c12 CHEMBL3702355 IC50 25.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OC(C)CC(C)(C)O)c12 CHEMBL3698944 IC50 25.0 nM
Cc1c(C(=O)NCC2CNCCO2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702282 IC50 25.0 nM
Cc1c(C(=O)NCC#CCN(C)C)sc2ncnc(Nc3ccc(C#N)cc3OC(CF)CF)c12 CHEMBL3702308 IC50 25.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCN(C)CC3)c12 CHEMBL4115554 IC50 25.0 nM
CN1CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4n3)cc2)CC1 CHEMBL4213168 IC50 25.0 nM
COc1cc(Nc2ncnc3ccc(-c4ccc(C(=O)N5CCNCC5)cc4)nc23)ccc1F CHEMBL4859971 IC50 25.0 nM
CC(C)(Nc1nccc(-c2c[nH]c3ncccc23)n1)c1ccccc1 CHEMBL1999279 pKi 25.12 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 25.12 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 25.12 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 25.12 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 25.12 nM
c1cnc2[nH]cc(-c3ccnc(NC4CCCCC4)n3)c2c1 CHEMBL385478 pKi 25.12 nM
CC(C)Oc1cc(C#N)ccc1Nc1ncnc2ccn(C)c12 CHEMBL5195560 pIC50 25.12 nM
O=C(c1ccc(-c2ccc3ncc(-c4ccc5cnccc5c4)n3c2)cc1)N1CCOCC1 CHEMBL4869957 IC50 25.7 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCCC(F)(F)F)c12 CHEMBL3702353 IC50 26.0 nM
COCC(C)Oc1ncccc1Nc1ncnc2sc(C(N)=O)c(C)c12 CHEMBL3702258 IC50 26.0 nM
CCNC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C CHEMBL3702280 IC50 26.0 nM
Cc1c(C(=O)NCC#N)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702295 IC50 26.0 nM
O=S1(=Nc2cc(C(F)(F)F)c3c(Nc4ccc(F)cc4OC(CF)CF)ncnc3c2)CCNCC1 CHEMBL3972374 IC50 26.0 nM
N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCNCC5)cc4)nn23)cc1 CHEMBL4208772 IC50 26.0 nM
O=C(c1ccc(-c2ccc3ncnc(Nc4ccc(F)cc4)c3n2)cc1)N1CCNCC1 CHEMBL4876307 IC50 26.0 nM
C=CC(=O)Nc1cc(-n2c(=O)ccc3cnc4ccc(-c5cn[nH]c5)cc4c32)ccc1C CHEMBL4075449 IC50 26.0 nM
N[C@@H]1CCCN(C(=O)c2ccc(-c3cn4c(-c5ccc6cnccc6c5)cnc4cn3)cc2)C1 CHEMBL4879113 IC50 26.7 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC3CCOCC3)c12 CHEMBL3659486 IC50 27.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OCCO)c12 CHEMBL3702347 IC50 27.0 nM
CNC(=O)CNC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C CHEMBL3702284 IC50 27.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H]3CCC[C@@H]3O)c12 CHEMBL4109449 IC50 27.0 nM
CCOc1cc(C(N)=O)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 CHEMBL3659484 IC50 28.0 nM
Cc1cc([C@@H](C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S4(=O)CCCC4)cc(C)c23)on1 CHEMBL4111425 IC50 28.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCC(O)C3)c12 CHEMBL4110929 IC50 28.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)CCc3ccccc3)c12 CHEMBL4115049 IC50 28.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)CNC(=O)C(F)(F)F)c12 CHEMBL4114116 IC50 28.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3640011 IC50 29.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCN)c12 CHEMBL3702315 IC50 29.0 nM
CCNC(=O)NC[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4107998 IC50 29.0 nM
COc1cc(F)ccc1Nc1ncnc2ccc(-c3ccc(C(=O)N4CCNCC4)cc3)nc12 CHEMBL4857156 IC50 29.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OCC(F)F)c12 CHEMBL3702334 IC50 30.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C(=O)NO)cc5)cnc4cn3)cc2)CC1 CHEMBL4214092 IC50 30.0 nM
COCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C CHEMBL3632746 Ki 31.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702289 IC50 31.0 nM
CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12 CHEMBL3702297 IC50 31.0 nM
Cn1ccc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCCOC3)c21 CHEMBL5187414 pIC50 31.62 nM
Cn1ccc2ncnc(Nc3ccc(F)cc3OC3CCCC3)c21 CHEMBL5184155 pIC50 31.62 nM
Fc1ccc2c(c1)CCN2c1ncnc2cc[nH]c12 CHEMBL5183411 pIC50 31.62 nM
CNC(=O)c1nc2c(Nc3ccc(F)cc3OC(C)C)ncnc2s1 CHEMBL5195407 pIC50 31.62 nM
CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCN3CCNCC3)nc12 CHEMBL5205835 pIC50 31.62 nM
CC(=O)Nc1ccc(-c2ccc(NCC(=O)Nc3ccc(CN4CCNCC4)c(C(F)(F)F)c3)cc2)cn1 CHEMBL3804921 IC50 32.0 nM
Cc1c(C(=O)NC2CCN(C)CC2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702287 IC50 32.0 nM
COCC(C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL3947558 IC50 32.0 nM
Nc1n[nH]c2cc(-c3ccc(=O)n(Cc4ccccc4)c3)ccc12 CHEMBL4755524 IC50 32.0 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1cccc(C(F)(F)F)c1 CHEMBL4746396 IC50 32.0 nM
CCN1CCN(Cc2ccc(NC(=O)COc3ccc(-c4ccc(NC(C)=O)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805865 IC50 33.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OCC(C)F)c12 CHEMBL3702255 IC50 33.0 nM
Cc1nnc(C(C)Oc2cc(F)ccc2Nc2ncnc3cc(N=S(C)(C)=O)cc(C)c23)o1 CHEMBL3908206 IC50 33.0 nM
O=C(c1ccc(-c2ccc3ncnc(Nc4cccc(F)c4)c3n2)cc1)N1CCNCC1 CHEMBL4859617 IC50 33.0 nM
CN(C)CCNC(=O)c1ccc(-c2nn3c(-c4ccc(C#N)cc4)cnc3s2)cc1 CHEMBL5278124 IC50 33.44 nM
Cc1c(C(=O)NCCN2CCOCC2)sc2ncnc(Nc3ccc(F)cc3OC3CCOCC3)c12 CHEMBL3659487 IC50 34.0 nM
CN(C)C(=O)c1cccc(-c2cnc(N)c(-c3nc4ccccc4[nH]3)c2)c1 CHEMBL3797574 IC50 34.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N(C)Cc3ccccc3)c12 CHEMBL4113475 IC50 34.0 nM
COCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC3CCOCC3)c2c1C CHEMBL3659485 IC50 35.0 nM
COCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 CHEMBL3702350 IC50 35.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCC(C)F)c12 CHEMBL3702354 IC50 35.0 nM
Cc1c(C(=O)NCCCN2CCCC2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702278 IC50 35.0 nM
CC(=O)NC[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4106564 IC50 35.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12 CHEMBL3702338 IC50 36.0 nM
O=C(c1ccc(-c2ccc3ncnc(Nc4ccccc4)c3n2)cc1)N1CCNCC1 CHEMBL4853562 IC50 36.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(C)C(C)(C)O)c12 CHEMBL3702316 IC50 37.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)c3nccs3)c12 CHEMBL3892514 IC50 37.0 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1ccccc1F CHEMBL4795993 IC50 37.0 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1cccc(F)c1 CHEMBL4791136 IC50 38.0 nM
CC(=O)C1=C(O)C=C2Oc3c(C(N)=O)c(O)cc(O)c3[C@]2(C)C1=O CHEMBL475816 IC50 38.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 39.81 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2-c2ccccc2)cc1 CHEMBL1969473 pKi 39.81 nM
CC(C)Oc1cc(F)ccc1Nc1ncnc2cc(C(=O)NCCCN(C)C)n(C)c12 CHEMBL5186068 pIC50 39.81 nM
CC(C)Oc1cc(F)ccc1Nc1ncnc2cc(C(=O)NCC3CCNCC3)n(C)c12 CHEMBL5203734 pIC50 39.81 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1cccc(Cl)c1 CHEMBL4749973 IC50 40.0 nM
Nc1cccc2c1cnn2-c1ncnc2[nH]ccc12 CHEMBL5173114 Ki 40.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(C)CN)c12 CHEMBL3698913 IC50 41.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNS(C)(=O)=O)c2c1C CHEMBL3698916 IC50 41.0 nM
N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)cc4)nn23)cc1 CHEMBL4203889 IC50 41.0 nM
O=C(c1ccc(-c2ccc3ncnc(Nc4ccc(C(F)(F)F)cc4)c3n2)cc1)N1CCNCC1 CHEMBL4848753 IC50 41.0 nM
O=C(c1ccc(-c2ccc3ncnc(Nc4ccc(O)cc4)c3n2)cc1)N1CCNCC1 CHEMBL4861251 IC50 41.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c12 CHEMBL3698949 IC50 42.0 nM
Cc1c(C(=O)NCCCCO)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702279 IC50 42.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)c3ccnn3C)c12 CHEMBL3912062 IC50 42.0 nM
CC(C)Oc1cc(-c2cncc(-c3cnn(C(C)C)c3)c2)ccc1C(N)=O CHEMBL4588193 IC50 42.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4787265 IC50 42.1 nM
O=C1NC2(CCCCC2)n2c1c(Cl)cc(Nc1ccon1)c2=O CHEMBL4466664 Ki 43.0 nM
CC(=O)Nc1cccc(Cn2cc(-c3ccc4cn[nH]c4c3)ccc2=O)c1 CHEMBL4750622 IC50 43.0 nM
N#Cc1ccc(Nc2ncnc3ccc(-c4ccc(C(=O)N5CCNCC5)cc4)nc23)cc1 CHEMBL4879010 IC50 43.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 44.0 nM
CCN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(C)=O)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805891 IC50 44.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OC(C)CCN)c12 CHEMBL3698939 IC50 44.0 nM
Cc1c(C(=O)NCCCN2CCOCC2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702281 IC50 44.0 nM
CC(C)Oc1cc(-c2cncc(-c3cnn(C4CCOC4)c3)c2)ccc1C(N)=O CHEMBL4443472 IC50 44.0 nM
Cc1c(C(=O)NCCCO)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702288 IC50 45.0 nM
CC1NC(=O)c2ccc(Nc3ccncn3)cc21 CHEMBL4099497 IC50 45.0 nM
Cc1c(C(=O)N[C@H]2CC[C@H](O)CC2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702294 IC50 46.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](CO)C(N)=O)c12 CHEMBL4114849 IC50 46.0 nM
COC(=O)c1sc2ncnc(Nc3cccnc3OCC3(CC#N)CC3)c2c1C CHEMBL3702273 IC50 47.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3cccnc3OCC(F)F)c12 CHEMBL3702265 IC50 48.0 nM
Cc1cc(Nc2ccnc(N)c2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4740694 IC50 48.2 nM
Cc1cc(Nc2cc(NC3CCNCC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4793971 IC50 49.8 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OC(C)CN)c12 CHEMBL3698914 IC50 50.0 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 50.12 nM
COc1cc(-c2ccc3[nH]nc(C(=O)Nc4ccccc4)c3c2)ccc1O CHEMBL2007002 pKi 50.12 nM
Cn1ccc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c21 CHEMBL5175341 pIC50 50.12 nM
CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCC3CCNCC3)nc12 CHEMBL5197975 pIC50 50.12 nM
O=C(c1ccc(-c2ccc3ncc(-c4cnc5ccccc5c4)n3c2)cc1)N1CCNCC1 CHEMBL4869672 IC50 51.2 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(=O)OC(C)(C)C)c12 CHEMBL3698909 IC50 52.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CCN)c2c1C CHEMBL3698930 IC50 52.0 nM
O=C(c1cccc(-c2ccc3ncnc(Nc4ccc(F)cc4)c3n2)c1)N1CCNCC1 CHEMBL4858115 IC50 52.0 nM
Cc1c(C(=O)NC2CCN(C)CC2)sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c12 CHEMBL3698948 IC50 54.0 nM
COC(=O)c1sc2ncnc(Nc3cccnc3OCC3CC3(F)F)c2c1C CHEMBL3702275 IC50 54.0 nM
Cc1c(C(=O)NCC(C)O)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702290 IC50 54.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)CF)c12 CHEMBL3899248 IC50 54.0 nM
CC(C)Oc1cc(-c2cncc(-c3c[nH]nc3C3CC3)c2)ccc1C(N)=O CHEMBL4462099 IC50 54.0 nM
Cc1c(C(=O)N[C@H]2C[C@@H]2N)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702283 IC50 55.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(CO)CO)c12 CHEMBL3702345 IC50 56.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)N3CCOCC3)c12 CHEMBL4106549 IC50 56.0 nM
CCC(=O)NC[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4108630 IC50 56.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3cccnc3OCC(F)F)c12 CHEMBL3702266 IC50 57.0 nM
CC1(C)NC(=O)c2ccc(Nc3ccncn3)c(=O)n21 CHEMBL4071021 IC50 57.0 nM
N#Cc1ccc(-c2cnc3sc(-c4ccc(C(=O)NCCCCCO)cc4)nn23)cc1 CHEMBL5288098 IC50 57.75 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3cccnc3OCC(C)F)c12 CHEMBL3702256 IC50 58.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OC(C)Cn3cccn3)c12 CHEMBL3962466 IC50 58.0 nM
CNC(=O)c1ccc(-c2ccc3ncnc(Nc4ccccc4)c3n2)cc1 CHEMBL4861078 IC50 58.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(C)CC(C)(C)O)c12 CHEMBL3698945 IC50 59.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL2012519 IC50 60.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-n3nc(-c4ccc(OCCN5CCOCC5)cc4)c4c(N)ncnc43)cc2)no1 CHEMBL4101411 IC50 61.0 nM
CC1(C)NC(=O)c2ccc(Nc3ccncn3)cc21 CHEMBL4086042 IC50 61.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3cccnc3OC(C)CCNS(C)(=O)=O)c12 CHEMBL3702299 IC50 62.0 nM
Cc1ccc(Nc2ncnc3ccc(-c4ccc(C(=O)N5CCNCC5)cc4)nc23)cc1 CHEMBL4849911 IC50 62.0 nM
Cc1c(C(=O)NCCN2CCCCC2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702286 IC50 63.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3OCC3COCCO3)c12 CHEMBL3970350 IC50 63.0 nM
CCCCNc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1968459 pKi 63.1 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 63.1 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 63.1 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 63.1 nM
CC(=O)N1CCN(c2cc(Nc3cc(C)c4n(c3=O)C3(CCCCC3)NC4=O)ncn2)CC1 CHEMBL4741081 IC50 63.8 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(C)CNCCC(F)(F)F)c12 CHEMBL3698926 IC50 64.0 nM
Cc1c(C(=O)NCC2COCCN2)sc2ncnc(Nc3cccnc3OC(C)C)c12 CHEMBL3702291 IC50 64.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OCC3(CC#N)CC3)c12 CHEMBL3702330 IC50 65.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OCCO)c12 CHEMBL3702348 IC50 65.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCC(F)(F)F)c12 CHEMBL3702332 IC50 66.0 nM
COCCNC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12 CHEMBL4110873 IC50 66.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OC(C)C)c12 CHEMBL3632742 Ki 68.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCCO)c12 CHEMBL3702349 IC50 69.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CN)c2c1C CHEMBL3698912 IC50 70.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3cccnc3OC(C)CCN)c12 CHEMBL3702298 IC50 70.0 nM
CN1CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4c3)cc2)CC1 CHEMBL4204438 IC50 72.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3cccnc3OCC(C)F)c12 CHEMBL3702257 IC50 73.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3cccnc3OC(C)CCN)c12 CHEMBL3698938 IC50 74.0 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1ccccc1 CHEMBL4789590 IC50 75.0 nM
CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)OC)c(C)c12 CHEMBL3702267 IC50 77.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCC3(CC#N)CC3)c12 CHEMBL3702331 IC50 78.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C CHEMBL3698954 IC50 78.0 nM
COCC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12 CHEMBL3702259 IC50 78.0 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1ccccc1Cl CHEMBL4752921 IC50 78.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)cc1C CHEMBL184847 pKi 79.43 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 79.43 nM
c1cnc2[nH]cc(-c3ccnc(NCC4CCCCC4)n3)c2c1 CHEMBL213207 pKi 79.43 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 79.43 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 79.43 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 79.43 nM
CC(C)Oc1cc(-c2cncc(-c3nn[nH]n3)c2)ccc1C(N)=O CHEMBL4587472 IC50 80.0 nM
CCC1CCN(Cc2ccc(NC(=O)COc3ccc(-c4cccnc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3804941 IC50 82.0 nM
O=C1NC2(CCCCC2)n2c1c(Cl)cc(Nc1ccncc1)c2=O CHEMBL4449736 Ki 82.0 nM
Cc1cc(Nc2cc(N3CCC(N)CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4797669 IC50 82.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)CNS(C)(=O)=O)c12 CHEMBL4113832 IC50 83.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3cccnc3OC(C)CCNS(C)(=O)=O)c12 CHEMBL3702302 IC50 84.0 nM
Nc1cccc(Cn2cc(-c3ccc4cn[nH]c4c3)ccc2=O)c1 CHEMBL4759018 IC50 84.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3cccnc3OCCO)c12 CHEMBL3702261 IC50 86.0 nM
CC(C)Oc1cc(-c2cncc(-c3cnn(C4COC4)c3)c2)ccc1C(N)=O CHEMBL4587832 IC50 89.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3O[C@@H](C)CN)c12 CHEMBL3698924 IC50 90.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CCNS(C)(=O)=O)c2c1C CHEMBL3698931 IC50 90.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC3CCN(Cc4ncon4)CC3)c12 CHEMBL3659490 IC50 92.0 nM
COCC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 CHEMBL3702260 IC50 93.0 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1ccc(Cl)c(Cl)c1 CHEMBL4762761 IC50 97.0 nM
Cc1cc(N=S(C)(C)=O)cc2ncnc(Nc3ccc(F)cc3O[C@H](C)CNS(=O)(=O)C(F)(F)F)c12 CHEMBL4109913 IC50 99.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 100.0 nM
Cc1ccccc1NC(=O)Nc1ccc2c(c1)CCc1sc3ncnc(N)c3c1-2 CHEMBL1982135 pKi 100.0 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 100.0 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 100.0 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1970203 pKi 100.0 nM
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1ccccc1C(F)(F)F CHEMBL4752471 IC50 100.0 nM
COC(=O)c1ccc(-c2cnc3sc(-c4ccc(C(=O)N5CCN(C)CC5)cc4)nn23)cc1 CHEMBL5289237 IC50 104.6 nM
NC(=O)c1cccc(Cn2cc(-c3ccc4cn[nH]c4c3)ccc2=O)c1 CHEMBL4790632 IC50 106.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(C)C)c12 CHEMBL3632743 Ki 110.0 nM
Fc1ccc(Nc2ncnc3sc4c(c23)CCNC4)c(OC2CCOCC2)c1 CHEMBL3659489 IC50 110.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCCN)c12 CHEMBL3702313 IC50 110.0 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(OC)cc3OC)n2)s1 CHEMBL4164283 Ki(app) 110.0 nM
COc1ccc(Nc2nccc(-c3c[nH]c4ccccc34)n2)c(OC)c1 CHEMBL4173067 Ki(app) 110.0 nM
O=C(c1ccc(-c2cn3c(-c4ccc(O)cc4)cnc3cn2)cc1)N1CCOCC1 CHEMBL4209905 IC50 110.0 nM
COc1ccc(Nc2ncnc3ccc(-c4ccc(C(=O)N5CCNCC5)cc4)nc23)cc1 CHEMBL4864209 IC50 111.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCN)c2c1C CHEMBL3702314 IC50 119.0 nM
Oc1ccccc1Nc1nccc(-c2c[nH]c3ccccc23)n1 CHEMBL4165526 Ki(app) 120.0 nM
Cc1c(-c2cncc(-c3ccc(C(N)=O)c(OC(C)C)c3)c2)cnn1C CHEMBL4440223 IC50 120.0 nM
Cc1c(-c2ccnc(Nc3ccccc3OC(F)F)n2)sc(=O)n1C CHEMBL5180186 Ki 120.0 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1 CHEMBL5202142 IC50 120.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(C#N)cc3OC(CF)CF)c2c1C CHEMBL3702303 IC50 125.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 125.89 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 125.89 nM
CCc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1968406 pKi 125.89 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 125.89 nM
COc1ccc(C=C2SC(=Nc3ccccc3)NC2=O)cc1O CHEMBL2000354 pKi 125.89 nM
CN(C)c1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2003229 pKi 125.89 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 125.89 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 125.89 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 Kd 130.0 nM
CC(C)C(=O)Nc1ccc(-c2ccc(NCC(=O)Nc3ccc(CN4CCNCC4)c(C(F)(F)F)c3)cc2)cn1 CHEMBL3804972 IC50 130.0 nM
CCN1CCN(Cc2ccc(NC(=O)COc3ccc(-c4cccnc4)cc3)cc2C2CC2)CC1 CHEMBL3806240 IC50 130.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 136.0 nM
Cc1cc(Nc2ccncc2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4751127 IC50 137.7 nM
CCC(Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(C)c12)C(=O)OC CHEMBL3956701 IC50 138.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(O)cc5)cnc4cn3)cc2)CC1 CHEMBL4209496 IC50 140.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CC(C)(C)O)c2c1C CHEMBL3698943 IC50 142.0 nM
CN(C)C1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C#N)cc5)cnc4cn3)cc2)CC1 CHEMBL4208246 IC50 143.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(CO)CO)c12 CHEMBL3702346 IC50 146.0 nM
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 CHEMBL1231206 IC50 148.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)/C=C\C[C@H](C)OC2=O CHEMBL1651521 IC50 150.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 158.49 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 158.49 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1995932 pKi 158.49 nM
Nc1ncnc2sc3c(c12)-c1ccc(NC(=O)Nc2ccccc2)cc1CC3 CHEMBL1994693 pKi 158.49 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 158.49 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(C)c3c2)nnn1Cc1ccccc1 CHEMBL1983315 pKi 158.49 nM
NC(=O)c1cccc2[nH]c(-c3ccncc3)nc12 CHEMBL1990482 pKi 158.49 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 158.49 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 158.49 nM
O=C(NCc1ccccc1)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL1972142 pKi 158.49 nM
C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1 CHEMBL1173442 Kd 160.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC3CCN(CC(=O)N4CCOCC4)CC3)c12 CHEMBL3659492 IC50 160.0 nM
CC(=O)N1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(O)cc5)cnc4cn3)cc2)CC1 CHEMBL4208890 IC50 160.0 nM
CC(C)Oc1cc(-c2cncc(-c3cnn(C)c3)c2)ccc1C(N)=O CHEMBL4457274 IC50 160.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 162.0 nM
Cc1cc(Nc2ccnnc2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4760245 IC50 162.3 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3)c12 CHEMBL3632740 Ki 164.0 nM
COCCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C CHEMBL3632747 Ki 164.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3O[C@@H](C)CNC(=O)OC(C)(C)C)c12 CHEMBL3698923 IC50 164.0 nM
CN1CCN(C(=O)c2ccc(-c3nn4c(-c5ccncc5)cnc4s3)cc2)CC1 CHEMBL5268626 IC50 169.7 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OC(CO)CO)c12 CHEMBL3702344 IC50 170.0 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 IC50 171.0 nM
COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)CCN)c2c1C CHEMBL3698936 IC50 174.0 nM
COCCn1cc(-c2ccnc(Nc3ccc(OC)cc3OC)n2)c2ccccc21 CHEMBL4159438 Ki(app) 180.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C(N)=O)cc5)cnc4cn3)cc2)CC1 CHEMBL4204506 IC50 187.0 nM
CC(C)Oc1ncccc1Nc1ncnc2cc(N=S(C)(C)=O)cc(F)c12 CHEMBL3905165 IC50 190.0 nM
NC(=O)c1ccc(-c2cn3c(-c4ccc(O)cc4)cnc3cn2)cc1 CHEMBL4212480 IC50 190.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 199.53 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 199.53 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 199.53 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 199.53 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5ccccc5)c4c3)nn2)cc1 CHEMBL1982400 pKi 199.53 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3Cl)ccc21 CHEMBL1987745 pKi 199.53 nM
CN(C)CC(=O)NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1991725 pKi 199.53 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 199.53 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 199.53 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 200.0 nM
COc1ccc(Nc2nccc(-c3sc(N(C)C)nc3C)n2)c(OC)c1 CHEMBL4162390 Ki(app) 200.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNS(=O)(=O)C(C)C)c2c1C CHEMBL3698917 IC50 204.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 205.0 nM
O=C(c1ccc(-c2ccc3ncc(-c4ccc5ncccc5c4)n3c2)cc1)N1CCOCC1 CHEMBL4848427 IC50 215.8 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(Cl)cc5)cnc4cn3)cc2)CC1 CHEMBL4211757 IC50 217.0 nM
COc1ccc(Nc2nccc(-c3cn(C(C)C)c4ccccc34)n2)c(OC)c1 CHEMBL4159011 Ki(app) 220.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 220.0 nM
Cc1cc(Nc2ccnc(N)n2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4784364 IC50 228.0 nM
CCC(CN)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)OC)c(C)c12 CHEMBL3698928 IC50 229.0 nM
Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(=O)OC(C)(C)C)c12 CHEMBL3698922 IC50 230.0 nM
COc1ccc(Nc2nccc(-c3sc(SCCN(C)C)nc3C)n2)c(OC)c1 CHEMBL4167646 Ki(app) 230.0 nM
COCCn1cc(C)cc(Nc2ncnc3sc(C(=O)O)c(C)c23)c1=O CHEMBL3417199 Ki 240.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 251.19 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 251.19 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 251.19 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 251.19 nM
Cc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1F CHEMBL243518 pKi 251.19 nM
Nc1ccc(-c2csc3c(C=Cc4nc5ccccc5[nH]4)cnc(N)c23)cc1 CHEMBL1988300 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 251.19 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 251.19 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 251.19 nM
COc1c(O)cc2oc(-c3ccc(O)cc3)cc(=O)c2c1O CHEMBL293776 IC50 252.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(C)=O)c2c1C CHEMBL3698919 IC50 261.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCN(C)C)c2c1C CHEMBL3702272 IC50 267.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 270.0 nM
COc1cc(O)c(C(N)=O)c2oc(C(=O)NC3CCN(Cc4cccc(C(F)(F)F)c4)CC3)c(C)c12 CHEMBL4248798 IC50 273.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3cccnc3OCCO)c12 CHEMBL3702262 IC50 288.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(=O)OC(C)(C)C)c12 CHEMBL3698911 IC50 294.0 nM
CCOCC(COCC)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 CHEMBL3698953 IC50 296.0 nM
COc1ccc(Nc2nccc(-c3cn(CCN4CCOCC4)c4ccccc34)n2)c(OC)c1 CHEMBL4167344 Ki(app) 300.0 nM
NC(=O)c1ccc(-c2cccnc2)cc1OC1CCCCC1 CHEMBL4456135 IC50 300.0 nM
Cc1cc(Nc2ncnc3sc(C(=O)O)c(C)c23)c(=O)n(C)c1 CHEMBL3417198 Ki 300.0 nM
O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 CHEMBL28 IC50 308.0 nM
Cn1ccc(-c2cncc(-c3ccc(C(N)=O)cc3)c2)n1 CHEMBL4558635 IC50 310.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCCN)c2c1C CHEMBL3702312 IC50 314.0 nM
OC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1993584 pKi 316.23 nM
Oc1ccc(Nc2ncnc3scc(Cl)c23)cc1 CHEMBL2006580 pKi 316.23 nM
Cc1cc(C)cc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1964687 pKi 316.23 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 316.23 nM
Cc1cc(-c2ccc3c(c2)Nc2ccccc2NC3=O)ccn1 CHEMBL1981511 pKi 316.23 nM
O=C(NCc1ccc(Cl)cc1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL1967094 pKi 316.23 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 316.23 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 316.23 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 316.23 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 316.23 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 316.23 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 316.23 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2coc3ncnc(N)c23)cc1 CHEMBL1984586 pKi 316.23 nM
NC(=O)c1ccc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)n2n1 CHEMBL4751394 Kd 330.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C(F)F)cc5)cnc4cn3)cc2)CC1 CHEMBL4202593 IC50 336.0 nM
COCCn1cc(C)cc(Nc2ncnc3sc(C(N)=O)c(C)c23)c1=O CHEMBL3417205 Ki 340.0 nM
Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 CHEMBL1240885 Ki 340.0 nM
CC(C)Oc1cc(-c2cccnc2)ccc1C(N)=O CHEMBL4450463 IC50 340.0 nM
NC(=O)c1ccccc1Cn1cc(-c2ccc3cn[nH]c3c2)ccc1=O CHEMBL4763087 IC50 340.0 nM
CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(=O)OC(C)(C)C)c2c1C CHEMBL3698910 IC50 342.0 nM
Cn1cc(-c2cncc(-c3ccc(C(N)=O)cc3)c2)cn1 CHEMBL4457368 IC50 350.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C(=O)O)cc5)cnc4cn3)cc2)CC1 CHEMBL4217366 IC50 355.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 Kd 360.0 nM
COc1ccc(Nc2nccc(-c3sc(=O)n(C)c3C)n2)c(OC)c1 CHEMBL4444307 IC50 370.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 380.0 nM
Cc1nn(CC(F)(F)F)cc1Nc1ncc(C2CC2)c(NCCCNC(=O)C2CCC2)n1 CHEMBL5079601 IC50 380.0 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)(F)F CHEMBL5082933 IC50 380.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C(F)(F)F)cc5)cnc4cn3)cc2)CC1 CHEMBL4212200 IC50 389.0 nM
Cc1cc(Nc2cn(C)nc2N)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4743829 IC50 389.0 nM
COc1ccc(Nc2nccc(-c3cn(C4CCCC4)c4ccccc34)n2)c(OC)c1 CHEMBL4169662 Ki(app) 390.0 nM
CC(C)Oc1cc(-c2cncc(N3CCOCC3)c2)ccc1C(N)=O CHEMBL4465294 IC50 390.0 nM
Cc1cc(Nc2cc(C)c3n(c2=O)C2(CCCCC2)NC3=O)ccn1 CHEMBL4741111 IC50 398.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 398.11 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 398.11 nM
O=c1[nH]c2cc(-c3ccccc3)cnc2[nH]1 CHEMBL2003456 pKi 398.11 nM
N#Cc1cnc(NC(=O)Nc2ccc3cc(C(=O)O)ccc3c2)cn1 CHEMBL560813 pKi 398.11 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 398.11 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 398.11 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 398.11 nM
O=c1cc(-c2ccncc2)nc(NCc2cc(F)cc(F)c2)[nH]1 CHEMBL2003682 pKi 398.11 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL2004631 pKi 398.11 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 398.11 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 398.11 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 398.11 nM
COc1ccc(Nc2nccc(-c3sc(SCc4cccnc4)nc3C)n2)c(OC)c1 CHEMBL4159419 Ki(app) 400.0 nM
Cc1ccc(-c2cnc3cnc(-c4ccc(C(=O)N5CCN(C)CC5)cc4)cn23)cc1 CHEMBL4212307 IC50 410.0 nM
NC(=O)c1ccc(-c2cncc(-c3ccccc3)c2)cc1 CHEMBL4453446 IC50 410.0 nM
Oc1ccc(-c2cnc3cnc(-c4ccccc4)cn23)cc1 CHEMBL4213023 IC50 415.0 nM
COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)CN)c2c1C CHEMBL3698929 IC50 418.0 nM
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC(F)F)c1 CHEMBL4872886 IC50 428.0 nM
CCn1cc(-c2ccnc(Nc3ccc(OC)cc3OC)n2)c2ccccc21 CHEMBL4174162 Ki(app) 430.0 nM
CCCn1cc(-c2ccnc(Nc3ccc(OC)cc3OC)n2)c2ccccc21 CHEMBL4166250 Ki(app) 430.0 nM
Fc1ccc(Nc2ncnc3[nH]ccc23)nc1 CHEMBL5174348 Ki 430.0 nM
O=C1NC2(CCCCC2)n2c1c(Cl)cc(Nc1ccncc1F)c2=O CHEMBL4535537 Ki 438.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(=O)C(C)C)c2c1C CHEMBL3698920 IC50 443.0 nM
Cc1cc(Nc2cc(N3CCCCC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4752750 IC50 452.0 nM
N#Cc1ccc(-c2cnc3cnc(-c4ccc(C(=O)N5CCOCC5)cc4)cn23)cc1 CHEMBL4213819 IC50 454.0 nM
Cc1cc(Nc2cc(N3CCOCC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 CHEMBL4797682 IC50 454.0 nM
Cc1c(C(=O)NCCO)sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(=O)OC(C)(C)C)c12 CHEMBL3639977 IC50 459.0 nM
NCCOc1cc(-c2cccnc2)ccc1C(N)=O CHEMBL4537933 IC50 460.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CCNC(C)=O)c2c1C CHEMBL3698932 IC50 471.0 nM
Cc1cc(F)ccc1Nc1ncnc2sc(C(=O)O)c(C)c12 CHEMBL3632741 Ki 500.0 nM
CC(C)Oc1cc(-c2cncc(N3CCCC3)c2)ccc1C(N)=O CHEMBL4441602 IC50 500.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C#N)cc5)cnc4cn3)cc2)CC1 CHEMBL4216991 IC50 500.0 nM
COc1cc(C=C2SC(=O)NC2=O)ccc1O CHEMBL2003286 pKi 501.19 nM
Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1C1CC(CN2CCCC2)C1 CHEMBL1968791 pKi 501.19 nM
O=c1c(NCc2ccc(Cl)c(Cl)c2)c(Nc2ccncc2)c1=O CHEMBL1975900 pKi 501.19 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 501.19 nM
CC(Nc1c(Nc2ccncc2)c(=O)c1=O)C(C)(C)C CHEMBL1986186 pKi 501.19 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 501.19 nM
CC(=O)N(c1ccncc1)c1c(NC(C)C(C)(C)C)c(=O)c1=O CHEMBL2005899 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)c1 CHEMBL185569 pKi 501.19 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 501.19 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 501.19 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 501.19 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(F)c(C)c3)cc2)c2c(N)noc12 CHEMBL1979093 pKi 501.19 nM
Brc1ccc2[nH]nc(-c3ccccc3)c2c1 CHEMBL1994074 pKi 501.19 nM
O=c1c(NCc2ccccc2F)c(Nc2ccncc2)c1=O CHEMBL1982361 pKi 501.19 nM
CC(=O)Nc1cn2c(-c3ccc(O)cc3)cnc2cn1 CHEMBL4208627 IC50 515.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(C(F)(F)F)nc3OC3CCOCC3)c12 CHEMBL3659488 IC50 560.0 nM
CCCCOc1nc(C)c(-c2ccnc(Nc3ccc(OC)cc3OC)n2)s1 CHEMBL4170718 Ki(app) 560.0 nM
c1cc(-c2cc(C3CCNCC3)n[nH]2)ccn1 CHEMBL1241462 IC50 575.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OCCN)c2c1C CHEMBL3698927 IC50 577.0 nM
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 CHEMBL151 IC50 579.0 nM
C[C@H]1C/C=C/[C@H]2OC(C)(C)O[C@H]2CC/C=C/c2cc(O)cc(O)c2C(=O)O1 CHEMBL2012392 IC50 580.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2OC)ncc1Cl CHEMBL2170016 IC50 600.0 nM
COc1ccc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)c1 CHEMBL4165841 Ki(app) 610.0 nM
c1ccc(Nc2ncnc3ccc(-c4ccccc4)nc23)cc1 CHEMBL4866350 IC50 612.0 nM
Nc1ccc(-c2ccc3ncc4ccc(=O)n(-c5cccc(C(F)(F)F)c5)c4c3c2)cn1 CHEMBL1765602 IC50 620.0 nM
O=C(c1cccc(-c2ccc3ncnc(Nc4ccccc4)c3n2)c1)N1CCNCC1 CHEMBL4846164 IC50 624.0 nM
CNC(=O)c1cncc(-c2ccc(C(N)=O)c(OC(C)C)c2)c1 CHEMBL4586717 IC50 630.0 nM
Nc1ncnc2onc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL213505 pKi 630.96 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccn1 CHEMBL1992306 pKi 630.96 nM
Cc1cc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1984363 pKi 630.96 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 630.96 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 630.96 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 630.96 nM
NC(=O)c1cc(-c2cccc(N)c2)cc2cccnc12 CHEMBL1970314 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 630.96 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 630.96 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 630.96 nM
CNc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL1981410 pKi 630.96 nM
CS(=O)(=O)NCCOc1cncc(-c2ccc3cnccc3c2)c1 CHEMBL1964804 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 630.96 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 630.96 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 630.96 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 630.96 nM
O=c1c(NCc2cccc(C(F)(F)F)c2)c(Nc2ccncc2)c1=O CHEMBL1979252 pKi 630.96 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 630.96 nM
COc1cccc2c1Nc1cc(Nc3ccncc3)ccc1C(=O)N2 CHEMBL2006276 pKi 630.96 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 630.96 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 630.96 nM
O=C(c1ccc(-c2ccc3ncc(-c4cnc5ccccc5c4)n3c2)cc1)N1CCOCC1 CHEMBL4862514 IC50 635.7 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CCNC(=O)C(C)C)c2c1C CHEMBL3698933 IC50 677.0 nM
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CN)CN)c2c1C CHEMBL3698940 IC50 691.0 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 720.0 nM
Nc1ncc(-c2ccccc2)cc1-c1nc2ccccc2[nH]1 CHEMBL3799935 IC50 720.0 nM
NC(=O)c1ccc(-c2cccnc2)cc1OC1CCC1 CHEMBL4473517 IC50 730.0 nM
CN1CCN(C(=O)c2ccc(-c3cn4c(-c5cccc(O)c5)cnc4cn3)cc2)CC1 CHEMBL4216093 IC50 740.0 nM
COc1cc(O)c(C(N)=O)c2occ(C)c12 CHEMBL4247747 IC50 749.0 nM
CCN1CCN(Cc2ccc(CC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805094 IC50 760.0 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)Nc1ccc2c(c1)CCNCC2 CHEMBL5303487 IC50 760.0 nM
O=C(NCCCNc1ccnc(Nc2cccc(NC(=O)N3CCCC3)c2)n1)C1CCC1 CHEMBL5075360 IC50 769.0 nM
Cc1c(C(=O)NCCCN(C)C)sc2ncnc(Nc3ccc(F)cc3OCC3CCOCC3)c12 CHEMBL3702254 IC50 790.0 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 794.33 nM
CC(N)COc1cnc(Cl)c(C=Cc2ccncc2)c1 CHEMBL1993548 pKi 794.33 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL262433 pKi 794.33 nM
O=C1NC(=S)SC1=C1C(=O)Nc2ccc(Br)cc21 CHEMBL2001920 pKi 794.33 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 794.33 nM
c1ccc(Nc2nc(-c3ccc4[nH]ncc4c3)cs2)cc1 CHEMBL1682545 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 794.33 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 794.33 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 794.33 nM
CCOc1cc(-c2cccnc2)ccc1C(N)=O CHEMBL4590023 IC50 800.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 820.0 nM
COCC(=O)NC/C=C/c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 CHEMBL483321 Kd 840.0 nM
COCCOc1nc(C)c(-c2ccnc(Nc3ccc(OC)cc3OC)n2)s1 CHEMBL4172170 Ki(app) 860.0 nM
CCCCNC(=O)NCCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)OC)c(C)c12 CHEMBL3698934 IC50 898.0 nM
Cc1c(C(=O)O)sc2ncnc(Nc3ccc(=O)n(C)c3)c12 CHEMBL3417207 Ki 900.0 nM
Nc1ncccc1-c1nc2ccccc2[nH]1 CHEMBL3797559 IC50 900.0 nM
COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5185000 IC50 900.0 nM
CC(=O)NC[C@@H](C)Oc1ccc2ncc(-c3cc4ccc(O)cc4o3)n2n1 CHEMBL5182166 IC50 904.0 nM
O/N=C1/c2ccccc2-c2nc3ccccc3nc21 CHEMBL3393601 Kd 920.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 950.0 nM
NC(=O)c1ccc(-c2cncc(-c3cccnc3)c2)cc1 CHEMBL4574792 IC50 970.0 nM
COc1cc(O)c2c(=O)cc(-c3ccc(O)cc3)oc2c1 CHEMBL210635 IC50 979.0 nM
COc1ccc(Nc2nccc(-c3sc(OC(C)C)nc3C)n2)c(OC)c1 CHEMBL4162781 Ki(app) 980.0 nM