COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1 CHEMBL475965 pEC50 6.31 nM
CCOc1ccc(F)cc1NC(=O)c1cc(F)ccc1NS(=O)(=O)C1CC1 CHEMBL5195160 EC50 13.0 nM
O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(CCCN1CCOCC1)Cc1c(Cl)cncc1Cl CHEMBL1762707 IC50 14.0 nM
CCOc1ccc(F)cc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 CHEMBL5172913 EC50 14.0 nM
Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL477008 pEC50 19.95 nM
O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1ccco1 CHEMBL1762698 IC50 20.0 nM
O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccccc1)Cc1ccncc1 CHEMBL1762699 IC50 22.0 nM
COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1 CHEMBL474473 pEC50 23.99 nM
O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1c(Cl)cncc1Cl CHEMBL1762700 IC50 24.0 nM
Cc1cccc(N2CCN(C(=O)c3ccc4c(c3)nc(-c3cccc(Oc5ccccc5)c3)n4[C@@H](CCCNC(=N)N)C(N)=O)CC2C)c1 CHEMBL3716029 pEC50 25.12 nM
CCOc1ccc(F)cc1NC(=O)c1cc(F)ccc1NS(=O)(=O)CC CHEMBL5205606 EC50 31.0 nM
O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)CC1CCCO1 CHEMBL1762701 IC50 40.0 nM
COc1ccccc1C(=O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3343995 IC50 50.0 nM
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)O CHEMBL3343989 EC50 50.0 nM
COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1ccc2c(N)nccc2c1 CHEMBL4460098 EC50 50.0 nM
Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(C(N)=O)c2)cc1 CHEMBL474474 pEC50 52.48 nM
CCOc1ccccc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 CHEMBL5202767 EC50 54.0 nM
CCOc1ccc(F)cc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 CHEMBL5185447 EC50 55.0 nM
CCC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 CHEMBL502132 pEC50 63.1 nM
COc1ccc(C(=O)O[C@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1OC CHEMBL3727438 IC50 64.0 nM
CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 CHEMBL5194692 EC50 69.0 nM
CCN(Cc1c(Cl)cncc1Cl)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 CHEMBL1760000 IC50 77.0 nM
COc1ccccc1C(O)/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3730717 IC50 80.0 nM
CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)CC CHEMBL5177145 EC50 80.0 nM
COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCCNCC5)c(Cl)c4=O)c3C)cc2)cn1 CHEMBL475077 pEC50 81.28 nM
COCCCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 CHEMBL1762702 IC50 88.0 nM
OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 CHEMBL3730500 IC50 90.0 nM
CCOc1ccccc1NC(=O)c1cc(F)ccc1NS(=O)(=O)CC CHEMBL5171656 EC50 98.0 nM
COc1ccccc1S(=O)(=O)Nc1ccc(C)cc1Oc1ccc(C(=N)N)cc1 CHEMBL4565294 EC50 100.0 nM
CC(C)(C)c1sc2ncnc(Oc3ccccc3OC(F)(F)F)c2c1-c1ccc(Cl)c(Cl)c1 CHEMBL5084093 EC50 100.0 nM
CCOc1ccccc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 CHEMBL5200001 EC50 103.0 nM
COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5C[C@H]6C[C@H]5CN6C)c(Cl)c4=O)c3C)cc2)cn1 CHEMBL448975 pEC50 107.15 nM
CCN(Cc1ccncc1Br)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 CHEMBL1762705 IC50 108.0 nM
COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCN(C)CC5)c(Cl)c4=O)c3C)cc2)cn1 CHEMBL475282 pEC50 123.03 nM
O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3730405 IC50 124.0 nM
CCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 CHEMBL5177388 EC50 124.0 nM
Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL458220 pEC50 125.89 nM
Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccc3ncccc3c2)cc1 CHEMBL449189 pEC50 131.83 nM
O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3730599 IC50 140.0 nM
Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccsc2)cc1 CHEMBL477432 pEC50 144.54 nM
Cc1ccc(NS(=O)(=O)c2ccccc2OC(F)(F)F)c(Oc2ccc(C(=N)N)cc2)c1 CHEMBL4455263 EC50 150.0 nM
N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCCc3ccccn3)ccc21 CHEMBL3717681 pEC50 158.49 nM
Cc1ccc(S(=O)(=O)Nc2ccc(C)cc2Oc2ccc(C(=N)N)cc2)cc1 CHEMBL4541091 EC50 160.0 nM
C(\Cc1ccccc1)=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3731811 IC50 163.0 nM
OC(/C=C1\C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 CHEMBL3727861 IC50 165.0 nM
CCOc1ccccc1NC(=O)c1cc(F)ccc1NS(=O)(=O)C1CC1 CHEMBL5208855 EC50 173.0 nM
CCC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 CHEMBL505263 pEC50 199.53 nM
CN(CCc1ccccn1)C(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O CHEMBL3719266 pEC50 199.53 nM
Cc1cc(C)cc(C(O)/C=C2\C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 CHEMBL3730179 IC50 200.0 nM
CCOc1ccc(F)cc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)CC CHEMBL5191110 EC50 206.0 nM
N#Cc1cccc(CO[C@@H]2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 CHEMBL3729794 IC50 209.0 nM
CCOc1ccccc1NC(=O)c1cc(C)ccc1NS(=O)(=O)CC CHEMBL5205025 EC50 217.0 nM
Cc1sc2ncnc(Oc3ccccc3F)c2c1C CHEMBL5080027 EC50 220.0 nM
CC(C)(C)c1sc2ncnc(Oc3ccccc3OC(F)(F)F)c2c1-c1ccc(F)cc1 CHEMBL5081104 EC50 230.0 nM
CCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 CHEMBL1762703 IC50 244.0 nM
FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3728505 IC50 244.0 nM
N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCN(c4ccc(F)cc4)CC3)ccc21 CHEMBL3717645 pEC50 251.19 nM
O=C(O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F CHEMBL3731844 IC50 252.0 nM
CCOc1ccc(F)cc1NC(=O)c1ccccc1NS(=O)(=O)CC CHEMBL5203677 EC50 285.0 nM
Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc3cccnc23)cc1 CHEMBL451657 pEC50 288.4 nM
O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3732603 IC50 290.0 nM
COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccsc1 CHEMBL4444915 EC50 290.0 nM
O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)CC1CC1 CHEMBL1762704 IC50 295.0 nM
CNCCNc1cnn(Cc2cccc(NC(=O)c3ccc(-c4ccc(OC)nc4)cc3)c2C)c(=O)c1Cl CHEMBL476627 pEC50 295.12 nM
CCCCS(=O)(=O)Nc1ccccc1Oc1ccc(C(=N)N)cc1 CHEMBL4454684 EC50 300.0 nM
CC(C)(C)c1sc2ncnc(Oc3ccccc3F)c2c1-c1ccc(F)cc1 CHEMBL5076018 EC50 300.0 nM
NS(=O)(=O)c1ccc(CCNc2ccnc(NCCc3ccc(Cl)cc3)n2)cc1 CHEMBL1762696 IC50 301.0 nM
CCC(C)[C@H]1C(=O)Nc2ccc(NCCOCCOCCN)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 CHEMBL466116 pEC50 316.23 nM
CCC(C)[C@H]1C(=O)Nc2ccc(N3CCC(NC(C)=O)C3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 CHEMBL503202 pEC50 316.23 nM
CC(C)(C)c1cc2c(Oc3ccccc3F)ncnc2s1 CHEMBL5094111 EC50 320.0 nM
CCN(Cc1ccccc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 CHEMBL1762706 IC50 330.0 nM
CC(C)(C)c1sc2ncnc(Oc3ccccc3F)c2c1-c1ccccc1 CHEMBL5092430 EC50 340.0 nM
CCS(=O)(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccccc1OCC(F)(F)F CHEMBL5179980 EC50 366.0 nM
Cc1ccc(NS(=O)(=O)C2CC2)c(C(=O)Nc2ccccc2OCC(F)(F)F)c1 CHEMBL5178316 EC50 369.0 nM
O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3733177 IC50 375.0 nM
Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(N(C)C)c2)cc1 CHEMBL474272 pEC50 398.11 nM
N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccc21 CHEMBL3717941 pEC50 398.11 nM
CCOc1ccccc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)CC CHEMBL5173653 EC50 407.0 nM
COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 CHEMBL3728009 IC50 418.0 nM
CCS(=O)(=O)Nc1ccc(F)cc1C(=O)Nc1ccccc1OCC(F)(F)F CHEMBL5190176 EC50 435.0 nM
Cc1ccccc1Oc1ncnc2sc(C)c(C)c12 CHEMBL5078996 EC50 480.0 nM
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)CC)C(C)C)C(=O)O CHEMBL4797453 EC50 500.0 nM
O=C(Nc1ccccc1OCC(F)(F)F)c1ccccc1NS(=O)(=O)C1CC1 CHEMBL5188039 EC50 502.0 nM
CCCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1 CHEMBL5191409 EC50 506.0 nM
COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccccc1 CHEMBL179938 EC50 510.0 nM
Cc1sc2ncnc(Oc3ccccc3C(F)(F)F)c2c1C CHEMBL5093049 EC50 520.0 nM
CC(CN(C)C)NC(=O)C1CCN(S(=O)(=O)c2ccc3nc(NCCc4ccc(Cl)cc4)nc(N4CCCC4)c3c2)CC1 CHEMBL1762693 IC50 530.0 nM
N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 CHEMBL145103 IC50 556.0 nM
Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccs2)cc1 CHEMBL477431 pEC50 588.84 nM
CC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)N4CCN(c5ccc(F)cc5)CC4)ccc3n21 CHEMBL501027 pEC50 630.96 nM
CCCCNC(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCNC(=N)N)C(N)=O CHEMBL3715864 pEC50 630.96 nM
NS(=O)(=O)c1ccc(CCNc2nc(NCCc3ccc(Cl)cc3)nc3ccccc23)cc1 CHEMBL1762695 IC50 640.0 nM
COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccc(-n2cccc2)cc1 CHEMBL4521959 EC50 680.0 nM
O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N1CCCCC1 CHEMBL1762697 IC50 758.0 nM
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)O)C(C)C CHEMBL506128 pEC50 794.33 nM
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C CHEMBL506884 pEC50 794.33 nM
COc1ccc(NC(=O)c2ccc3c(c2)nc(-c2cccc(Oc4ccccc4)c2)n3[C@@H](CCCNC(=N)N)C(N)=O)cc1 CHEMBL3716921 pEC50 794.33 nM
CCOc1ccccc1NC(=O)c1ccc(F)cc1NS(=O)(=O)C1CC1 CHEMBL5205161 EC50 860.0 nM
O=C(Nc1ccccc1OCC(F)(F)F)c1cc(Cl)ccc1NS(=O)(=O)C1CC1 CHEMBL5169615 EC50 915.0 nM
CCCCS(=O)(=O)Nc1cc(C)ccc1Oc1ccc(C(=N)N)cc1 CHEMBL4445698 EC50 920.0 nM