CCc1ncnc(-c2cc(F)c(C(=O)N3CCN4CCC[C@H]4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645910 IC50 0.07 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(CO)cc5)cc4)nc32)CC1 CHEMBL558955 IC50 0.08 nM
CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc21 CHEMBL3545097 Kd 0.092 nM
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C CHEMBL413 IC50 0.1 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)nc21 CHEMBL566004 IC50 0.1 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(CO)cc4)cc3)nc21 CHEMBL566216 IC50 0.1 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(CCO)cc4)cc3)nc21 CHEMBL585480 IC50 0.1 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)NCCN(C)C)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1091714 IC50 0.1 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(CCO)cc5)cc4)nc32)CC1 CHEMBL1098245 IC50 0.1 nM
COC(=O)N1CCC(n2ncc3c(N4CC5CCC(C4)O5)nc(-c4ccc(NC(=O)Nc5cccnc5)cc4)nc32)CC1 CHEMBL573157 IC50 0.11 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cnc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681183 Ki 0.117 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C(C)C)c3n2)cc1 CHEMBL604123 IC50 0.12 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCO5)c3n2)cc1 CHEMBL600367 IC50 0.12 nM
O=C(Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCO5)c3n2)cc1)Nc1cccnc1 CHEMBL600368 IC50 0.12 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO CHEMBL1801204 IC50 0.13 nM
CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(C4CCOCC4)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1091358 IC50 0.14 nM
CNC(=O)c1cccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)c1 CHEMBL2336325 Kd 0.14 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1C(=O)O CHEMBL3693444 IC50 0.15 nM
COC(=O)N1CCC(n2ncc3c(N4C5CCC4COC5)nc(-c4ccc(NC(=O)Nc5cccnc5)cc4)nc32)CC1 CHEMBL573202 IC50 0.16 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCO5)c3n2)cc1 CHEMBL600366 IC50 0.16 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)OCC)CC4)c3n2)cc1 CHEMBL578645 IC50 0.17 nM
O=C(Nc1ccc(CO)cc1)Nc1ccc(-c2nc(N3C4CCC3COC4)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1091596 IC50 0.18 nM
COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL1236962 IC50 0.18 nM
O=C(Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CC(F)(F)F)c3n2)cc1)Nc1cccnc1 CHEMBL575976 IC50 0.19 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCN(C(=O)OC(C)C)CC4)c3n2)cc1 CHEMBL606423 IC50 0.19 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCO5)c3n2)cc1 CHEMBL601661 IC50 0.19 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5cccnc5)cc4)nc32)CC1 CHEMBL538378 IC50 0.2 nM
CCNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL577137 IC50 0.2 nM
O=C(Nc1ccc(-c2nc(N3C4CCC3COC4)c3cnn(CC(F)(F)F)c3n2)cc1)Nc1cccnc1 CHEMBL567172 IC50 0.2 nM
O=C(Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CC(F)(F)F)c3n2)cc1)Nc1ccc(N2CCNCC2)cc1 CHEMBL576506 IC50 0.2 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(CN)cc4)cc3)nc21 CHEMBL565583 IC50 0.2 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NN5CCCC5)cc4)cc3)nc21 CHEMBL576090 IC50 0.2 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(N5CCOCC5)cc4)cc3)nc21 CHEMBL576091 IC50 0.2 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3cnn(CC(F)(F)F)c3n2)cc1)Nc1cccnc1 CHEMBL574680 IC50 0.2 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)OC(C)C)CC4)c3n2)cc1 CHEMBL1095932 IC50 0.2 nM
Cc1nc(N)nc(-n2c(Nc3cc(O)cc(O)c3)nc3ccccc32)n1 CHEMBL1762790 IC50 0.2 nM
COc1ncc(-c2ccc3ncnc(-c4ccncc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577911 IC50 0.2 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(CO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645914 IC50 0.2 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cn[nH]c4)ccc3ncc21 CHEMBL3681103 Ki 0.204 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(Cc4cc(C)no4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645963 IC50 0.21 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL568259 IC50 0.22 nM
CNC(=O)Nc1ccc(-c2nc(N3C4CCC3COC4)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL574012 IC50 0.22 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC(=O)CC4)c3n2)cc1 CHEMBL603498 IC50 0.22 nM
O=C(NCCF)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCO5)c3n2)cc1 CHEMBL601023 IC50 0.22 nM
O=C(Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCO5)c3n2)cc1)NC1CC1 CHEMBL600213 IC50 0.22 nM
O=C(NCCF)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL574905 IC50 0.23 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn([C@H]4CC[C@H](O)CC4)c3n2)cc1 CHEMBL610630 IC50 0.24 nM
C[C@@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL3681175 Ki 0.241 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL2331668 Ki 0.243 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCC(N(C)C)CC4)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1092389 IC50 0.25 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(C(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645913 IC50 0.25 nM
Nc1ccc(-c2ccc3ncc4ccc(=O)n(-c5cccc(C(F)(F)F)c5)c4c3c2)cn1 CHEMBL1765602 IC50 0.25 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3n2)cc1 CHEMBL600084 IC50 0.26 nM
CCNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCO5)c3n2)cc1 CHEMBL600825 IC50 0.26 nM
O=C(Nc1ccc(OCCO)cc1)Nc1ccc(-c2nc(N3C4CCC3COC4)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1092398 IC50 0.26 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C)C(=O)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645911 IC50 0.26 nM
C[C@@H]1CN(c2nc(N3CCOC[C@@H]3C)c3ccc(-c4ccc(O)cc4)nc3n2)C[C@H](C)O1 CHEMBL3688907 IC50 0.26 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCO3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643265 IC50 0.27 nM
Nc1cc(C(F)F)c(-c2nc(N3C4CCC3COC4)nc(N3C4CCC3COC4)n2)cn1 CHEMBL4286698 Kd 0.27 nM
CCOC(=O)N1CCC(n2ncc3c(N4CCOC[C@H]4C)nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc32)CC1 CHEMBL573663 IC50 0.28 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C4CCCC4O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645967 IC50 0.28 nM
O=C(Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1)Nc1cccnc1 CHEMBL595256 IC50 0.29 nM
CCC(=O)N1CCN(c2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc2C(F)(F)F)CC1 CHEMBL1256459 IC50 0.29 nM
COc1ncc(-c2ccc3nc(N)nc(-c4ccncc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577914 IC50 0.29 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC(C)(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645912 IC50 0.29 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N)nc5)nc4c32)CC1 CHEMBL3681165 Ki 0.299 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc32)CC1 CHEMBL557963 IC50 0.3 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(N5CCOCC5)nc4)cc3)nc21 CHEMBL576304 IC50 0.3 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccccc4)cc3)nc21 CHEMBL565787 IC50 0.3 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(N5CCN(C)CC5)cc4)cc3)nc21 CHEMBL576505 IC50 0.3 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NN(C)C)cc4)cc3)nc21 CHEMBL577967 IC50 0.3 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn([C@H]4CC[C@@H](O)CC4)c3n2)cc1 CHEMBL606621 IC50 0.3 nM
CC(C)OC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)NCCF)cc4)nc32)CC1 CHEMBL1094981 IC50 0.3 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(N6CCN(C)CC6)cc5)cc4)nc32)CC1 CHEMBL556947 IC50 0.3 nM
O=C(NCCO)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1 CHEMBL1097896 IC50 0.3 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccccc5)cc4)nc32)CC1 CHEMBL1098244 IC50 0.3 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N(C)CCN(C)C)cc5)cc4C3=O)c2c1 CHEMBL1082621 IC50 0.3 nM
CC(C)Oc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N(C)CCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808986 IC50 0.3 nM
O=C(Nc1ccc(C(=O)NCCN2CCCC2)cc1)Nc1ccc(-c2nc(O[C@H]3CCOC3)nc(N3CCOCC3)n2)cc1 CHEMBL1808990 IC50 0.3 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1ccnc3ccc-2cc13 CHEMBL4850101 IC50 0.3 nM
CC1(Cn2nc(-c3ccc4oc(N)nc4c3F)c3c(N)nc(N)nc32)CCC1 CHEMBL5219718 Ki 0.3 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(N)=O)cc4)cc3)nc21 CHEMBL591760 IC50 0.31 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL558486 IC50 0.32 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(CO)cc4)cc3)nc21 CHEMBL600258 IC50 0.32 nM
O=C(Nc1ccc(CCO)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1258296 IC50 0.32 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C4CCCC4O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645974 IC50 0.32 nM
COCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL3681176 Ki 0.323 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn([C@H]4CC[C@@H](OC)CC4)c3n2)cc1 CHEMBL601445 IC50 0.33 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cnc(N)nc4)ccc3ncc21 CHEMBL3681154 Ki 0.33 nM
O=C(NCCO)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1 CHEMBL593157 IC50 0.34 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(C5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091357 IC50 0.34 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3c(n2)[C@](C)(CCO)OC3)cc1 CHEMBL1774364 Ki 0.34 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(N5CCOCC5)cc4)cc3)nc21 CHEMBL591761 IC50 0.35 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643219 IC50 0.35 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4ccc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681182 Ki 0.359 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(S(=O)(=O)CC)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643272 IC50 0.36 nM
COCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(C)nc5)nc4c32)CC1 CHEMBL2331666 Ki 0.377 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5cccnc5)CC4)c3n2)cc1 CHEMBL551440 IC50 0.38 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn([C@H]4CC[C@H](OC)CC4)c3n2)cc1 CHEMBL602276 IC50 0.38 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(N3CC4CCC(C3)O4)ccnc21 CHEMBL1090381 IC50 0.38 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(N)=O)cc4)cc3)nc21 CHEMBL591759 IC50 0.39 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)N4CCN(CCO)CC4)cc3)ccnc21 CHEMBL1092781 IC50 0.39 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4cc(C)no4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645978 IC50 0.39 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(CNS(C)(=O)=O)cc3)nc2n1 CHEMBL3688937 IC50 0.39 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(N4CCNCC4)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1091360 IC50 0.4 nM
CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4ccn(CC(F)(F)F)c4n3)cc2)cc1 CHEMBL1092073 IC50 0.4 nM
CC(C)(C)OC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(N)cc4)nc32)CC1 CHEMBL1095627 IC50 0.4 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL592445 IC50 0.4 nM
CC(C)Oc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)NCCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808987 IC50 0.4 nM
O=C(Nc1ccc(C(=O)NCCN2CCCCC2)cc1)Nc1ccc(-c2nc(O[C@H]3CCOC3)nc(N3CCOCC3)n2)cc1 CHEMBL1808989 IC50 0.4 nM
CC(=O)Nc1cn2nc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 CHEMBL1822054 IC50 0.4 nM
C[C@H]1COCCN1c1nc(-c2ccc(Nc3nccc(=O)[nH]3)cc2)nc2c1CCN(c1ncccn1)C2 CHEMBL2331687 Ki 0.4 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(N4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643222 IC50 0.4 nM
Nc1nc2cc(-c3nn(CC4CCN(C(=O)c5ccc(C(=O)NO)s5)CC4)c4ncnc(N)c34)ccc2o1 CHEMBL4879288 IC50 0.4 nM
CC(C)C[C@H](C)n1nc(-c2ccc3oc(N)nc3c2F)c2c(N)nc(N)nc21 CHEMBL5218727 Ki 0.4 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cccc5[nH]ccc45)ccc3ncc21 CHEMBL3681160 Ki 0.404 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccncc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914727 IC50 0.41 nM
CC(C)N1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5C6CCC5COC6)nc(N5CCOC[C@H]5C)n4)cc3)cc2)CC1 CHEMBL1091713 IC50 0.42 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1258517 IC50 0.42 nM
O=C(Nc1ccc(CO)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1258183 IC50 0.43 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1 CHEMBL592917 IC50 0.44 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681123 Ki 0.444 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)NC5CC5)cc4)nc32)CC1 CHEMBL562999 IC50 0.45 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc(N4CC5CCC(C4)O5)c3s2)CC1 CHEMBL594431 IC50 0.45 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(Cc4nc(C)c(C)o4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645973 IC50 0.45 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4ncon4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648886 IC50 0.45 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL563985 IC50 0.46 nM
CC(C)N1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(C5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091356 IC50 0.46 nM
Cn1cc(/C=C2\Oc3cc(O)cc(O)c3C2=O)c2c(-c3ccccc3)ccnc21 CHEMBL1091456 IC50 0.46 nM
CCc1ncnc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643263 IC50 0.46 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4cnnc4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645926 IC50 0.46 nM
COc1ccc(C(=O)NNC(=O)c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)cc1 CHEMBL5278435 IC50 0.46 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645916 IC50 0.47 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCN(Cc5cccnc5)CC4)c3n2)cc1 CHEMBL580212 IC50 0.48 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(Cc4nc(C)c(C)o4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645966 IC50 0.49 nM
Nc1nc2cc(-c3nn(CC4CCN(c5ncc(C(=O)NO)cn5)CC4)c4ncnc(N)c34)ccc2o1 CHEMBL4862549 IC50 0.49 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL572944 IC50 0.5 nM
CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL592615 IC50 0.5 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCN(C)C)cc4)cc3)nc21 CHEMBL590587 IC50 0.5 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)N4CCOCC4)cc3)ccnc21 CHEMBL1091492 IC50 0.5 nM
CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCN(C)C)cc4)cc3)nc21 CHEMBL1092402 IC50 0.5 nM
CC(C)OC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)NC5CC5)cc4)nc32)CC1 CHEMBL1097942 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)NCCF)cc4)nc32)CC1 CHEMBL1098242 IC50 0.5 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1 CHEMBL550972 IC50 0.5 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1)Nc1cccnc1 CHEMBL1258516 IC50 0.5 nM
CCC(C)(C)Cn1nc(-c2ccc3oc(NC(C)=O)nc3c2)c2c(N)nc(N)nc21 CHEMBL5218590 Ki 0.5 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL590074 IC50 0.51 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCn4ccnc4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645829 IC50 0.51 nM
O=C1OC[C@H](c2ccc(F)c(Cl)c2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653608 IC50 0.51 nM
O=C1OC[C@H](c2ccc(F)cn2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653617 IC50 0.51 nM
O=C1OC[C@H](c2ccc(F)cc2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653621 IC50 0.51 nM
CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(C5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091350 IC50 0.52 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC4(CC3)CC(=O)CO4)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645977 IC50 0.52 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC4(CC3)COC4)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645832 IC50 0.53 nM
O=C(Nc1ccc(-c2nc(C3CCOCC3)nc(N3C4CCC3COC4)n2)cc1)Nc1ccc(N2CCNCC2)cc1 CHEMBL1091351 IC50 0.535 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCCS(C)(=O)=O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645821 IC50 0.54 nM
CN(C)C(=O)c1ccc(-c2ccnc3c2c(/C=C2\Oc4cccc(O)c4C2=O)cn3C)cc1 CHEMBL1092815 IC50 0.55 nM
CNC(=O)Nc1ccc(-c2nc(N3C4CCC3COC4)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL567822 IC50 0.56 nM
CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4nnn(CC)c4n3)cc2)cc1 CHEMBL591357 IC50 0.56 nM
CCN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(C5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091352 IC50 0.56 nM
CN(C)C1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(C5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091354 IC50 0.56 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)N4CC5CCC(C4)O5)cc3)ccnc21 CHEMBL1092120 IC50 0.56 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C(C)COC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645964 IC50 0.56 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645975 IC50 0.56 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)nc21 CHEMBL589345 IC50 0.57 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CC4)c3n2)cc1)Nc1cccnc1 CHEMBL601462 IC50 0.57 nM
O=C(Nc1ccc(-c2nc(N3C4CCC3COC4)nc(N3C4CCC3COC4)n2)cc1)Nc1ccc(N2CCNCC2)cc1 CHEMBL1092391 IC50 0.57 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCN(C)CC4)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1092390 IC50 0.57 nM
CN1CCN(CC(=O)N2CCN(c3ccc(-n4c(=O)ccc5cnc6ccc(-c7cnc8ccccc8c7)cc6c54)cc3C(F)(F)F)CC2)CC1 CHEMBL1256458 IC50 0.57 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645923 IC50 0.57 nM
CCOC(=O)N1CCC(n2ncc3c(N4CCOC[C@@H]4C)nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc32)CC1 CHEMBL573662 IC50 0.58 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C(C)CO)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645965 IC50 0.58 nM
CC1(Cn2nc(-c3ccc4oc(N)nc4c3)c3c(N)nc(N)nc32)CCC1 CHEMBL5220536 Ki 0.58 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCn4cnnc4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645830 IC50 0.59 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCC(CO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645877 IC50 0.59 nM
O=C(NCCF)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL574234 IC50 0.6 nM
CCNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CC)c3n2)cc1 CHEMBL584734 IC50 0.6 nM
CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(N5CC6CCC(C5)O6)c5cnn(CC(F)(F)F)c5n4)cc3)cc2)CC1 CHEMBL570833 IC50 0.6 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4ccc(NC(=O)Nc5cccnc5)cc4)nc(N4CC5CCC(C4)O5)c3s2)CC1 CHEMBL594549 IC50 0.6 nM
CN(C)CCN(C)C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL1204015 IC50 0.6 nM
CN(C)CCN(C)C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4ccn(CC(F)(F)F)c4n3)cc2)cc1 CHEMBL1092072 IC50 0.6 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(CCN6CCOCC6)cc5)cc4)nc32)CC1 CHEMBL1098248 IC50 0.6 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)NCCF)cc4)nc32)CC1 CHEMBL561907 IC50 0.6 nM
CC(C)(C)OC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)NC5CC5)cc4)nc32)CC1 CHEMBL1098243 IC50 0.6 nM
CC(C)(C#N)c1ccc(N2C(=O)OCc3cnc4ccc(-c5cnc6ccccc6c5)cc4c32)cc1 CHEMBL3334621 IC50 0.6 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641010 IC50 0.6 nM
CC(C)(C)Cn1nc(-c2ccc3oc(N)nc3c2)c2c(N)nc(N)nc21 CHEMBL5220152 Ki 0.6 nM
CC1(Cn2nc(-c3ccc4oc(N)nc4c3)c3c(N)nc(N)nc32)CSC1 CHEMBL5220948 Ki 0.6 nM
CCc1ncnc(N2CCC(O)(C(C)C)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670201 IC50 0.61 nM
COC(=O)N1CCC(n2ncc3c(N4CCOC(C)C4)nc(-c4ccc(NC(=O)Nc5cccnc5)cc4)nc32)CC1 CHEMBL573171 IC50 0.62 nM
CCNC(=O)Nc1ccc(-c2nc(N3C4CCC3COC4)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL575576 IC50 0.62 nM
COC(=O)N1CCC(n2ncc3c(N4CC5CCC(C4)O5)nc(-c4ccc(NC(=O)NC5CC5)cc4)nc32)CC1 CHEMBL583874 IC50 0.62 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL590073 IC50 0.63 nM
CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2cncnc21 CHEMBL3798574 IC50 0.63 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(N4CCOCC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645908 IC50 0.64 nM
Cn1c(=O)n(C2CCN(C(=O)C(C)(C)O)CC2)c2c3nc(-c4cnc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681177 Ki 0.658 nM
CCNC(=O)Nc1ccc(-c2nc(N3C[C@H]4CC[C@@H](C3)O4)c3c(n2)[C@](C)(CCO)OC3)cc1 CHEMBL1774365 Ki 0.66 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4ncon4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648882 IC50 0.66 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701053 IC50 0.66 nM
CN(C)C(=O)C1CCN(c2ccnc3c2c(/C=C2\Oc4cccc(O)c4C2=O)cn3C)CC1 CHEMBL1091491 IC50 0.67 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C(C)C)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645906 IC50 0.67 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4ccnc4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645927 IC50 0.67 nM
C[C@@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)F)nc(N2[C@H](C)COC[C@@H]2C)n1 CHEMBL4749352 Kd 0.67 nM
O=C(Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1)NC1CC1 CHEMBL594793 IC50 0.68 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCOCC4)CC3)c(Cl)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645858 IC50 0.68 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCCC4O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645960 IC50 0.68 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C(C)COC)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645971 IC50 0.68 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(N5CCN(C)CC5)nc4)cc3)nc21 CHEMBL577966 IC50 0.7 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(CN5CCN(C)CC5)cc4)cc3)nc21 CHEMBL577743 IC50 0.7 nM
CCNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1 CHEMBL595053 IC50 0.7 nM
O=C(NCCF)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1 CHEMBL595287 IC50 0.7 nM
CNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL597825 IC50 0.7 nM
O=C(Nc1ccc(C(=O)N2CCC(N3CCCCC3)CC2)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL592619 IC50 0.7 nM
CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(N5C6CCC5COC6)nc(N5[C@H](CO)CC[C@@H]5CO)n4)cc3)cc2)CC1 CHEMBL1091344 IC50 0.7 nM
CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(C5=CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091349 IC50 0.7 nM
CN(C)CCOc1ccc(NC(=O)Nc2ccc(-c3nc(C4CCOCC4)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1091359 IC50 0.7 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1)Nc1ncc[nH]1 CHEMBL1097902 IC50 0.7 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3n2)cc1 CHEMBL1095933 IC50 0.7 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(CCN6CCCC6)cc5)cc4)nc32)CC1 CHEMBL1098246 IC50 0.7 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@](C)(CCO)OC3)cc1 CHEMBL1774363 Ki 0.7 nM
CN(C)CCN(C)C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(O[C@H]4CCOC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL1808977 IC50 0.7 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C4CCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645827 IC50 0.7 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCCS(C)(=O)=O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645828 IC50 0.71 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(N3CCC(C(N)=O)CC3)ccnc21 CHEMBL1094015 IC50 0.72 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1)Nc1cncnc1 CHEMBL1258635 IC50 0.73 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCCC[C@@H]4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645820 IC50 0.73 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCC#N)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645915 IC50 0.73 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)NC)cc3)nc21 CHEMBL600811 IC50 0.74 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC(OC)(OC)CC4)c3n2)cc1 CHEMBL601660 IC50 0.74 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCS(=O)(=O)C4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641006 IC50 0.74 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N(C)C)cc4)cc3)nc21 CHEMBL591358 IC50 0.75 nM
COc1ncc(-c2ccc3nccc(-c4ccncc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577908 IC50 0.75 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCOCCO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645976 IC50 0.76 nM
Cc1nc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)ccc1F CHEMBL3653639 IC50 0.79 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(OCCN(C)C)cc4)cc3)nc21 CHEMBL570635 IC50 0.8 nM
O=C(Nc1ccc(C(=O)N2CCC(N3CCCC3)CC2)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL592461 IC50 0.8 nM
O=C(Nc1ccc(OCCN2CCCC2)cc1)Nc1ccc(-c2nc(N3C4CCC3COC4)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1092397 IC50 0.8 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(CCN6CCN(C)CC6)cc5)cc4)nc32)CC1 CHEMBL1098247 IC50 0.8 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1)Nc1cccnc1 CHEMBL1097901 IC50 0.8 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1 CHEMBL1098306 IC50 0.8 nM
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1255815 IC50 0.8 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4COCC3[C@@H](O)C4)n2)cc1 CHEMBL1258744 IC50 0.8 nM
Cc1nc(N)nc2c1nc(-c1cc[nH]n1)c(=O)n2C1CCOCC1 CHEMBL1258911 Ki 0.8 nM
C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3cnn(C)c3)cc2)nc2c1COC2(C)C CHEMBL1774358 Ki 0.8 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4COCC3C(O)C4)n2)cc1 CHEMBL3526762 Activity 0.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CC(O)CO3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643264 IC50 0.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4c(C)cnc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645918 IC50 0.8 nM
CCC(C)(C)Cn1nc(-c2ccc3oc(N)nc3c2F)c2c(N)nc(N)nc21 CHEMBL5218916 Ki 0.8 nM
CC(C)C[C@H](C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)nc(N)nc21 CHEMBL5219710 Ki 0.8 nM
COc1ccc(-c2ccc3c(C4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO CHEMBL5265783 IC50 0.8 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(C5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091355 IC50 0.81 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCn4ccnc4C3)c(F)c2)cn1 CHEMBL3645931 IC50 0.81 nM
CCc1ncnc(-c2ccc(C(=O)N3CCNC(=O)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641018 IC50 0.82 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cn1 CHEMBL3681095 Ki 0.822 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)c5cccnc5)CC4)c3n2)cc1 CHEMBL540695 IC50 0.83 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CC4)c3n2)cc1 CHEMBL590325 IC50 0.84 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)C)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641016 IC50 0.84 nM
Nc1nc2cc(-c3nn(CC4CCN(C(=O)c5ccc(C(=O)NO)cc5)CC4)c4ncnc(N)c34)ccc2o1 CHEMBL4861461 IC50 0.84 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cn1 CHEMBL2331663 Ki 0.842 nM
Cc1ccc(-c2nc3c(C)nc(N)nc3n([C@H]3CC[C@H](O)CC3)c2=O)cn1 CHEMBL1257295 Ki 0.85 nM
CCC(CC)n1cnc2c(-c3cnc(N)cn3)nc(N3CC4CCC(C3)O4)nc21 CHEMBL4279703 Kd 0.85 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@H]3C)c3cnn(C4CCN(C(=O)OCC)CC4)c3n2)cc1 CHEMBL567607 IC50 0.87 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN4CCC[C@H]4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645866 IC50 0.87 nM
O=C1OC[C@H](c2ccc(F)c(F)c2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653615 IC50 0.87 nM
CC(C)N1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(C5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091353 IC50 0.88 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641005 IC50 0.88 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC4(CC3)COC4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645825 IC50 0.88 nM
C[C@@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)F)nc(N2CCOCC2(C)C)n1 CHEMBL4741511 Kd 0.88 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)nc21 CHEMBL589103 IC50 0.89 nM
CNCc1ccc(NC(=O)Nc2ccc(-c3nc(N4C5CCC4COC5)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1092394 IC50 0.89 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCn4cnnc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645823 IC50 0.89 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCNS(C)(=O)=O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645826 IC50 0.89 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(NC)nc4)cc3)nc21 CHEMBL567694 IC50 0.9 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(N(C)CCN(C)C)cc4)cc3)nc21 CHEMBL570870 IC50 0.9 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1 CHEMBL606131 IC50 0.9 nM
CN1CCN(CCOc2ccc(NC(=O)Nc3ccc(-c4nc(N5C6CCC5COC6)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1092396 IC50 0.9 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(N4CCC(N(C)C)CC4)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1091712 IC50 0.9 nM
CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCNCC5)cc4)cc3)nc21 CHEMBL1092404 IC50 0.9 nM
C[C@H](NC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOC[C@@H]4C)n3)cc2)cc1)C(N)=O CHEMBL5071085 IC50 0.9 nM
CCc1ncnc(-c2ccc(C(=O)N(C)C3CCS(=O)(=O)C3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645783 IC50 0.92 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)COC)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645979 IC50 0.92 nM
CN1CCN(c2ccnc3c2c(/C=C2\Oc4cc(O)cc(O)c4C2=O)cn3C)CC1 CHEMBL1094017 IC50 0.94 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643220 IC50 0.94 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643224 IC50 0.94 nM
C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC CHEMBL269732 IC50 0.95 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(C(C)(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645909 IC50 0.96 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4c(C)cnc4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645925 IC50 0.97 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)C[C@@H]2CC[C@H]3N2S(C)(=O)=O)cc1 CHEMBL2334764 Ki 0.99 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641002 IC50 0.99 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCC[C@@H]4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645814 IC50 0.99 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)OCCO)cc4)nc32)CC1 CHEMBL564404 IC50 1.0 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL572932 IC50 1.0 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(OCCN5CCOCC5)nc4)cc3)nc21 CHEMBL576305 IC50 1.0 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4ccc(NC(=O)NC5CC5)cc4)nc(N4CC5CCC(C4)O5)c3s2)CC1 CHEMBL594244 IC50 1.0 nM
O=C(NCCF)Nc1ccc(-c2nc(C3=CCOCC3)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL590104 IC50 1.0 nM
O=C(Nc1ccc(-c2nc(C3=CCOCC3)c3cnn(CC(F)(F)F)c3n2)cc1)Nc1cccnc1 CHEMBL590105 IC50 1.0 nM
CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(N5C6CCC5COC6)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1088973 IC50 1.0 nM
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4nc(N5C6CCC5COC6)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1092392 IC50 1.0 nM
CN1CCN(C(=O)c2ccc(-c3ccnc4c3c(/C=C3\Oc5cccc(O)c5C3=O)cn4C)cc2)CC1 CHEMBL1092485 IC50 1.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3cc[nH]c3n2)cc1 CHEMBL1089141 IC50 1.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CC(F)(F)F)c3n2)cc1 CHEMBL1090780 IC50 1.0 nM
COC(Cn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21)OC CHEMBL1090781 IC50 1.0 nM
COc1ccc2[nH]c(-c3cccnc3)c(/C=C3\Oc4cc(O)cc(O)c4C3=O)c2c1 CHEMBL1093445 IC50 1.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@@](C)(CC2CC2)OC3)cc1 CHEMBL1774361 Ki 1.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3C[C@H]4CC[C@@H](C3)O4)c3c(n2)[C@@](C)(CCO)OC3)cc1 CHEMBL1774368 Ki 1.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3CC)c3c(cnn3C)n2)cc1 CHEMBL2418349 Ki 1.0 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3ncccc3n2)cc1)Nc1cccc(CO)c1 CHEMBL3109141 IC50 1.0 nM
CCc1ncnc(N2CCC(O)(C(F)(F)F)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670158 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCCO)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640979 IC50 1.0 nM
CCCCN1CCN(C(=O)c2ccc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2Cl)CC1 CHEMBL3641003 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCO)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641008 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643061 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCOC)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643062 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCNC(=O)C3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643069 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(F)F)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643071 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643080 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C(C)(C)O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643087 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@H](O)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643176 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)NCC3(C)COC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643187 IC50 1.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)C3CCS(=O)(=O)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643189 IC50 1.0 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645905 IC50 1.0 nM
Cc1nccc(-c2ccc(C(=O)N(C)C)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701063 IC50 1.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701087 IC50 1.0 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCC[C@H]4C(N)=O)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL5080996 IC50 1.0 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C(C)CO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645972 IC50 1.01 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCNCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643227 IC50 1.02 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(C)(C)O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648889 IC50 1.03 nM
Cn1c(=O)n(C2CCOCC2)c2c3nc(-c4cn[nH]c4)ccc3ncc21 CHEMBL3681125 Ki 1.03 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)NN)CC2)c(=O)n4C)cn1 CHEMBL3681112 Ki 1.06 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCOCC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643262 IC50 1.09 nM
CCc1ncnc(-c2ccc(C(=O)N3CCc4ncccc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645961 IC50 1.09 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)N(C)C)CC4)c3n2)cc1 CHEMBL562439 IC50 1.1 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(CN(C)C)cc4)cc3)nc21 CHEMBL585206 IC50 1.1 nM
O=C(Nc1ccc(-c2nc(C3=CCOCC3)c3sccc3n2)cc1)Nc1cccnc1 CHEMBL601895 IC50 1.1 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCN5CCN(C)CC5)cc4)cc3)nc21 CHEMBL589612 IC50 1.1 nM
CN(C)Cc1ccc(NC(=O)Nc2ccc(-c3nc(N4C5CCC4COC5)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1092393 IC50 1.1 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N(C)CCN(C)C)cc5)cc4C3=O)c2c1 CHEMBL1082619 IC50 1.1 nM
CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1255813 IC50 1.1 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4F)c3)cc2s1 CHEMBL1773735 IC50 1.1 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@@](C)(CCC#N)OC3)cc1 CHEMBL1774369 Ki 1.1 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(O[C@H]5CCOC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1808988 IC50 1.1 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3968925 IC50 1.1 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCC(C(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645872 IC50 1.11 nM
O=c1[nH]c(=O)n(-c2cccc(C(F)(F)F)c2)c2c1cnc1ccc(-c3cnc4[nH]ccc4c3)nc12 CHEMBL3927003 IC50 1.12 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCNS(C)(=O)=O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645917 IC50 1.13 nM
Cn1c(=O)n(C2CCOCC2)c2c3nc(-c4cnc(N)nc4)ccc3ncc21 CHEMBL3681136 Ki 1.13 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCC[C@H]4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645817 IC50 1.15 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCOCCO)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648885 IC50 1.15 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCN(C)CC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643261 IC50 1.18 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4cnnc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645919 IC50 1.18 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CN(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681109 Ki 1.18 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C4CCC5(CC4)OCCCO5)c3n2)cc1 CHEMBL601876 IC50 1.19 nM
O=C(Nc1ccc(-c2nc(N3C[C@@H]4C[C@H]3CO4)c3cnn(CC(F)(F)F)c3n2)cc1)Nc1cccnc1 CHEMBL575989 IC50 1.2 nM
CCOC(=O)N1CCC(n2ncc3c(N4CCOC[C@H]4C)nc(-c4ccc(NC(=O)NCCF)cc4)nc32)CC1 CHEMBL572679 IC50 1.2 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1)Nc1cccnc1 CHEMBL599668 IC50 1.2 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL596597 IC50 1.2 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(N4CCN(C)CC4)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1091348 IC50 1.2 nM
CCN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(N5C6CCC5COC6)nc(N5CCOC[C@H]5C)n4)cc3)cc2)CC1 CHEMBL1076864 IC50 1.2 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)C(C)(C)OC3=O)cc1 CHEMBL1773085 Ki 1.2 nM
C[C@H]1COCCN1c1nc(-c2ccc(Nc3cccc(=O)[nH]3)cc2)nc2c1COC2(C)C CHEMBL1774360 Ki 1.2 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)C[C@@H]2CC[C@H]3N2C(C)(C)C(=O)NC)cc1 CHEMBL2334767 Ki 1.2 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)C[C@@H]2CC[C@H]3N2C(C)=O)cc1 CHEMBL2334765 Ki 1.2 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)C[C@@H]2CC[C@H]3N2C)cc1 CHEMBL2334761 Ki 1.2 nM
O=C1OC[C@H](c2ccc(F)c(Cl)c2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653607 IC50 1.2 nM
C[C@@H]1CN(C(=O)Nc2ccc(-c3nc(N4CCOCC4)c4cnn(CCCCCCC(=O)NO)c4n3)cc2)CCO1 CHEMBL4532398 IC50 1.2 nM
C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCC(C(N)=O)CC4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL5085872 IC50 1.2 nM
COc1ncc(-c2ccc3ncc(C#N)c(N4CCOCC4)c3c2)cc1NS(C)(=O)=O CHEMBL5426067 IC50 1.2 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCc5ccccn5)cc4)cc3)nc21 CHEMBL590357 IC50 1.21 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC4CCCCC4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645791 IC50 1.23 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645907 IC50 1.24 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sccc3n2)cc1 CHEMBL594571 IC50 1.25 nM
CC(C)N1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(N5C6CCC5COC6)nc(N5CCOC[C@H]5C)n4)cc3)cc2)CC1 CHEMBL1091711 IC50 1.25 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1)Nc1ccnc(Cl)c1 CHEMBL1258634 IC50 1.26 nM
CN1CCN(C(=O)c2ccc(-c3ccc(-n4c(=O)ccc5cnc6ccc(-c7cnc8ccccc8c7)cc6c54)cc3C(F)(F)F)cc2)CC1 CHEMBL1256460 IC50 1.26 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)CO)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645958 IC50 1.26 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(Cc4cc(C)no4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645970 IC50 1.26 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCOCCO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645984 IC50 1.28 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643214 IC50 1.29 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCCC4O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645982 IC50 1.29 nM
CNC(=O)Nc1ccc2c(c1)C(=O)/C(=C\c1c(-c3c(C)nn(C)c3C)[nH]c3ccc(OC)cc13)O2 CHEMBL1083912 IC50 1.3 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1257839 IC50 1.3 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@](C)(CC2CC2)OC3)cc1 CHEMBL1774362 Ki 1.3 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@](C)(CCC#N)OC3)cc1 CHEMBL1774370 Ki 1.3 nM
CC(C)Oc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCN(C)CC4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808985 IC50 1.3 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4CC)n2)CCN(c2ncccn2)C3)cc1 CHEMBL2181523 Ki 1.3 nM
O=C1OC[C@H](c2cccc(F)c2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653625 IC50 1.3 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(C)c3n2)cc1 CHEMBL601864 IC50 1.34 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN(CC(C)(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645871 IC50 1.34 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cccc6[nH]ncc56)nc4c32)CC1 CHEMBL2331667 Ki 1.34 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCn4ccnc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645822 IC50 1.36 nM
CCc1ncnc(-c2ccc(C(=O)N(C)OC)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643270 IC50 1.37 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN(CCC#N)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645878 IC50 1.38 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCN(CCNS(C)(=O)=O)CC3)c(F)c2)cn1 CHEMBL3645935 IC50 1.39 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n([C@H]5CC[C@H](O)CC5)c4c3n2)cn1 CHEMBL3681079 Ki 1.39 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCNCC4)c3n2)cc1 CHEMBL551442 IC50 1.4 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3sc(CN4CCN(S(C)(=O)=O)CC4)cc3n2)cc1 CHEMBL604167 IC50 1.4 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1204014 IC50 1.4 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(N3CCC(C(=O)N4CCOCC4)CC3)ccnc21 CHEMBL1092119 IC50 1.4 nM
CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCN(C)CC5)cc4)cc3)nc21 CHEMBL1092403 IC50 1.4 nM
O=C(NCCF)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1 CHEMBL1097893 IC50 1.4 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)C(C)(C)OC3)cc1 CHEMBL1774353 Ki 1.4 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2cccnn2)C3)cc1 CHEMBL2181525 Ki 1.4 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2nccn2C)C3)cc1 CHEMBL2331677 Ki 1.4 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN(CC)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645870 IC50 1.4 nM
NC(=O)C1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5074018 IC50 1.4 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCS(=O)(=O)C4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645776 IC50 1.41 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681108 Ki 1.41 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cn1 CHEMBL2331664 Ki 1.41 nM
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL1879463 IC50 1.43 nM
C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)C2C[C@@](O)(C(=O)C(=O)N3CCCCC3C(=O)O[C@H](C(C)C[C@@H]3CC[C@@H](CC(=O)Nc4ccc(CCCC(=O)OC)cc4)C(OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC CHEMBL411735 IC50 1.45 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCn4cnnc4C3)c(F)c2)cn1 CHEMBL3645932 IC50 1.46 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)COC4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645838 IC50 1.47 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCNS(C)(=O)=O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645924 IC50 1.47 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5cccnc5)CC4)c3n2)cc1)OCCO CHEMBL552532 IC50 1.5 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(N(C)C)nc4)cc3)nc21 CHEMBL565987 IC50 1.5 nM
O=C(Nc1ccc(C(=O)O)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL597824 IC50 1.5 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c2c1 CHEMBL1082616 IC50 1.5 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2ncccn2)C3)cc1 CHEMBL2181522 Ki 1.5 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)C[C@@H]2CC[C@H]3N2C2COC2)cc1 CHEMBL2334763 Ki 1.5 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCC[C@H]4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645816 IC50 1.5 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4nc(C)c(C)o4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645981 IC50 1.5 nM
CC(C)[C@H]1CN(CCCO)C(=O)N1c1ccn2ncc(-c3ccc(-c4ncc[nH]4)cc3)c2n1 CHEMBL3653529 IC50 1.5 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(C(C)O)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645885 IC50 1.51 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4cc(C)no4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645956 IC50 1.51 nM
C[C@H]1COCCN1c1cc(C2(S(=O)(=O)C3CC3)CC2)nc(-c2ccc(NC(=S)NCCO)cc2)n1 CHEMBL3410672 pIC50 1.514 nM
CCCCN1CCN(C(=O)c2ccc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2C)CC1 CHEMBL3643276 IC50 1.52 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4nc(C)c(C)o4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645959 IC50 1.53 nM
COc1ncc(-c2ccc3ncc4[nH]c(=O)n(-c5ccc(C(C)(C)C#N)cc5)c4c3n2)cn1 CHEMBL3681060 Ki 1.54 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1)Nc1ccnnc1 CHEMBL1258743 IC50 1.55 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCN(CCCS(C)(=O)=O)CC3)c(F)c2)cn1 CHEMBL3645929 IC50 1.55 nM
CCc1ncnc(-c2ccc(C(=O)N(C)C3CCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645843 IC50 1.56 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(C)O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645962 IC50 1.56 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643278 IC50 1.57 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(N(C)C)cc4)cc3)nc21 CHEMBL590578 IC50 1.6 nM
CN(C)CCOc1ccc(NC(=O)Nc2ccc(-c3nc(N4C5CCC4COC5)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1092395 IC50 1.6 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3ccc4nc(NC(C)=O)sc4c3)cnc2C#N)cc1 CHEMBL1773602 IC50 1.6 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(C(F)(F)F)cc4)c3)cc2s1 CHEMBL1773729 IC50 1.6 nM
C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NCCO)cc2)nc2c1COC2(C)C CHEMBL1774355 Ki 1.6 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4cccnc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914726 IC50 1.6 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](N(C)C)C3)c(Cl)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645861 IC50 1.6 nM
CNC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(OC)nc5)nc4c32)CC1 CHEMBL3681085 Ki 1.6 nM
O=C1OC[C@H](C2CCCCC2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653574 IC50 1.6 nM
CCC[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653584 IC50 1.6 nM
O=C1OC[C@H](c2cccc(Cl)c2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653644 IC50 1.6 nM
CNCc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1 CHEMBL3688986 IC50 1.6 nM
CNC1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL4065928 IC50 1.6 nM
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C CHEMBL1908360 IC50 1.6 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCC(N4CCOCC4)CC3)c(F)c2)cn1 CHEMBL3645930 IC50 1.61 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCC(C(C)(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645873 IC50 1.62 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCn4c(C)cnc4C3)c(F)c2)cn1 CHEMBL3645933 IC50 1.63 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCN(C4CCC4)CC3)c(F)c2)cn1 CHEMBL3645936 IC50 1.64 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCOCCO)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645968 IC50 1.66 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)CO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645980 IC50 1.68 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCC[C@@H]4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645815 IC50 1.69 nM
C[C@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccnc6[nH]ncc56)nc4c32)CC1 CHEMBL3681173 Ki 1.69 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(NCCN(C)C)cc4)cc3)nc21 CHEMBL576507 IC50 1.7 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1)Nc1cccs1 CHEMBL599667 IC50 1.7 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCN(C)CC5)cc4)cc3)nc21 CHEMBL589258 IC50 1.7 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(OCCN(C)C)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1091715 IC50 1.7 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)c5ccn(CC(F)(F)F)c5n4)cc3)cc2)CC1 CHEMBL1092074 IC50 1.7 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)c5ccn(CC(F)(F)F)c5n4)cc3)cc2)CC1 CHEMBL1092401 IC50 1.7 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@](C)(CCOC)OC3)cc1 CHEMBL1774373 Ki 1.7 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@](C)(CO)OC3)cc1 CHEMBL1774375 Ki 1.7 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(O[C@H]5CCOC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1808991 IC50 1.7 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2cnccn2)C3)cc1 CHEMBL2181524 Ki 1.7 nM
Cc1nc(N)nc(-c2c(Nc3ccc4cccnc4c3)nc3ccccn23)n1 CHEMBL3618236 IC50 1.7 nM
CC(C)[C@H]1CN(CCO)C(=O)N1c1ccn2ncc(-c3ccc(-c4ncc[nH]4)cc3)c2n1 CHEMBL3653528 IC50 1.7 nM
O=C1OC[C@H](C2CCCC2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653609 IC50 1.7 nM
COc1ccccc1[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653630 IC50 1.7 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N(C)CCO)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4741551 IC50 1.7 nM
Nc1nc2cc(-c3nn(CCCCCCC(=O)NO)c4ncnc(N)c34)ccc2o1 CHEMBL4846560 IC50 1.7 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC4(CC3)CNC4)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645836 IC50 1.71 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681121 Ki 1.72 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681126 Ki 1.72 nM
C[C@@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681140 Ki 1.74 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCn4c(C)cnc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645824 IC50 1.75 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4ccnc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645920 IC50 1.75 nM
Cn1c(=O)n(C2CCN(C(=O)CO)CC2)c2c3nc(-c4ccnc5[nH]ncc45)ccc3ncc21 CHEMBL3681172 Ki 1.77 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCC(C)CC4)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643267 IC50 1.78 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](N(C)C)C3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645778 IC50 1.78 nM
CNC(=O)Nc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cc1 CHEMBL3681166 Ki 1.78 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3cnn(C4CCN(C(=O)OCC)CC4)c3n2)cc1 CHEMBL572500 IC50 1.8 nM
CCOC(=O)N1CCC(n2ncc3c(N4CCOC[C@@H]4C)nc(-c4ccc(NC(=O)NCCF)cc4)nc32)CC1 CHEMBL576782 IC50 1.8 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(C3=CCOCC3)c3sccc3n2)cc1 CHEMBL601689 IC50 1.8 nM
O=C(Nc1ccc(CCO)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL605121 IC50 1.8 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3c(n2)[C@](C)(CC(C)(C)O)OC3)cc1 CHEMBL1774380 Ki 1.8 nM
Nc1nc2cc(-c3nn(CC4CCCC4)c4ncnc(N)c34)ccc2o1 CHEMBL3797933 IC50 1.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CC(O)CO3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645771 IC50 1.82 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645792 IC50 1.83 nM
CCC1CCCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(OC)c(CO)c3)nc2n1 CHEMBL3688830 IC50 1.84 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(N3CCC(C(=O)N4CCN(CCO)CC4)CC3)ccnc21 CHEMBL1093754 IC50 1.85 nM
CN(C)CCOc1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1255814 IC50 1.85 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4C[C@@H](C)O[C@@H](C)C4)nc3n2)cc1CO CHEMBL2335862 IC50 1.85 nM
C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)C2C[C@@](O)(C(=O)C(=O)N3CCCCC3C(=O)O[C@H](C(C)C[C@@H]3CC[C@@H](CC(=O)Nc4ccc(CCCC(=O)O)cc4)C(OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC CHEMBL265123 IC50 1.88 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCNS(C)(=O)=O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645833 IC50 1.88 nM
O=C(Nc1ccc(-c2nc(N3C[C@@H]4C[C@H]3CO4)c3cnn(CC(F)(F)F)c3n2)cc1)NC1CC1 CHEMBL575539 IC50 1.9 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC(C)C3)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL576937 IC50 1.9 nM
O=C(Nc1ccc(CO)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL597004 IC50 1.9 nM
O=C(Nc1ccc(F)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1257840 IC50 1.9 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(CNC4CCOCC4)cc3)nc2n1 CHEMBL3688990 IC50 1.9 nM
Nc1nc2cc(-c3nn(CC4CCN(C(=O)CCCCC(=O)NO)CC4)c4ncnc(N)c34)ccc2o1 CHEMBL4847270 IC50 1.9 nM
NC(=O)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL5076528 IC50 1.9 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(Cl)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645859 IC50 1.93 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cc1 CHEMBL3681187 Ki 1.94 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(N4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645887 IC50 1.96 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(CNCCO)cc3)nc2n1 CHEMBL3688991 IC50 1.967 nM
Cn1c(=O)n(C2CCN(C(=O)CO)CC2)c2c3nc(-c4cccc5[nH]ncc45)ccc3ncc21 CHEMBL3681174 Ki 1.97 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@H](O)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643148 IC50 1.99 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN(C)C(=O)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645867 IC50 1.99 nM
COc1ccc(-c2ccc3ncc4c(c3c2)n(-c2ccc(N3CCNCC3)c(C(F)(F)F)c2)c(=O)n4C)cn1 CHEMBL3218578 IC50 1.99 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)NC)CC4)c3n2)cc1 CHEMBL558288 IC50 2.0 nM
CNC(=O)Nc1ccc(-c2nc(C3=CCOCC3)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL589858 IC50 2.0 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(N3CCC(C(=O)N4CC5CCC(C4)O5)CC3)ccnc21 CHEMBL1090388 IC50 2.0 nM
CN(C)CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL1092841 IC50 2.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CCO)c3n2)cc1 CHEMBL1092071 IC50 2.0 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1257955 IC50 2.0 nM
CNC(=O)Nc1ccc(Nc2nc3ccccc3n2-c2nc(C)nc(N)n2)cc1 CHEMBL1760154 IC50 2.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2s1 CHEMBL1615189 IC50 2.0 nM
O=c1[nH]c2ncc(-c3ccc(-c4nc[nH]n4)cc3)nc2n1CC1CCOCC1 CHEMBL1945953 IC50 2.0 nM
Nc1nc2cc(-c3cnc4[nH]c(=O)n(CC5CCCCC5)c4n3)ccc2[nH]1 CHEMBL1946264 IC50 2.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4cnn(C5CC5)c4)cn23)n1 CHEMBL2172489 IC50 2.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4cncnc4)cn23)n1 CHEMBL2172485 IC50 2.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4cnccc4C)cn23)n1 CHEMBL2172482 IC50 2.0 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL2331659 Ki 2.0 nM
O=c1[nH]c2ncc(-c3ccc(-c4nc[nH]n4)cc3)nc2n1CCC1CCOCC1 CHEMBL2348865 IC50 2.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3CC)c3c(n2)c(C)nn3C)cc1 CHEMBL2418350 Ki 2.0 nM
Cn1c(=O)n(-c2ccc(C3(C#N)CC3)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3354566 IC50 2.0 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3ccc4c(ccn4S(C)(=O)=O)c3n2)cc1 CHEMBL3393593 IC50 2.0 nM
Cc1ncnc(-c2ccc(C(=O)N(C)C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640935 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640940 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCO)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640981 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCOC)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640982 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640983 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640986 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(=O)N(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640997 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCOC)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641009 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(F)F)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641015 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)(C)C)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641017 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641019 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)=O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641020 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(F)F)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641021 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641023 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)C)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641024 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(S(=O)(=O)CC)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643065 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)=O)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643066 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643068 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643073 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCN(C)CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643074 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)C3CCC(C)(O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3639419 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCN(C5CCN(C)CC5)CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643076 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643109 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)C(=O)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643138 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](O)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643177 IC50 2.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N(C)C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643188 IC50 2.0 nM
CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3650232 IC50 2.0 nM
O=C1OC[C@H](c2ccccc2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653583 IC50 2.0 nM
O=C1OC[C@H](c2ccc(Cl)cn2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653627 IC50 2.0 nM
Cc1nc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)cc4)c3n2)ccc1F CHEMBL3653640 IC50 2.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701054 IC50 2.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701060 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701078 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(CC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701082 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C(C)=O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3639999 IC50 2.0 nM
CCCN1CCN(C(=O)c2ccc(-c3ccnc(CC)c3C#Cc3ccc(N)nc3)cc2F)CC1 CHEMBL3701124 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(CC4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701125 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701127 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCC(C)(O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701130 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCC(O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701131 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701132 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(CCOC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701133 IC50 2.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(CC(=O)N(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701134 IC50 2.0 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(C(C)(C)C)nc3n2)cc1CO CHEMBL4238656 IC50 2.0 nM
NC(=O)[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5083002 IC50 2.0 nM
CC(C)n1nc(-c2ccc3nc(N)oc3c2)c2c(N)ncnc21 CHEMBL3962632 IC50 2.0 nM
CC(C)CC1(C)CN(c2ccc3oc(N)nc3c2)c2c(N)ncnc21 CHEMBL5218988 Ki 2.0 nM
CNC(=O)Nc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cc1 CHEMBL3681167 Ki 2.03 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CCC4(CC3)COC4)c(F)c2)cn1 CHEMBL3645934 IC50 2.09 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n(-c5ccc(C(C)(C)C#N)cc5)c4c3n2)cn1 CHEMBL3681054 Ki 2.09 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(C)=O)CC4)c3n2)cc1 CHEMBL562365 IC50 2.1 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(N3C4CCC3COC4)ccnc21 CHEMBL1090382 IC50 2.1 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3ccc4nc(NC(C)=O)sc4c3)cnc2Cl)cc1 CHEMBL1773604 IC50 2.1 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4cccc(C(C)(C)C)c4)c3)cc2s1 CHEMBL1773733 IC50 2.1 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3)cc2s1 CHEMBL1773734 IC50 2.1 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)C[C@@H]2CC[C@H]3N2C(=O)COC)cc1 CHEMBL2334766 Ki 2.1 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(O)c3)nc2n1 CHEMBL3688835 IC50 2.1 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCCC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4787768 IC50 2.1 nM
NC(=O)C1CCCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)C1 CHEMBL5091543 IC50 2.1 nM
C[C@@H](NC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1)C(N)=O CHEMBL5093540 IC50 2.1 nM
CCc1ncnc(-c2cc(F)c(C(=O)N(C)CCN(C)C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645845 IC50 2.11 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC4(CC3)CC(=O)CO4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645969 IC50 2.11 nM
CCCN1CCN(C(=O)c2c(F)cc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2F)CC1 CHEMBL3643217 IC50 2.14 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645888 IC50 2.14 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n([C@H]5CC[C@H](OCCO)CC5)c4c3n2)cn1 CHEMBL3681078 Ki 2.14 nM
Cc1nc(N)nc2c1cc(-c1cn[nH]c1)c(=O)n2[C@H]1CC[C@H](OCO)CC1 CHEMBL2375967 Ki 2.15 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCOC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643218 IC50 2.15 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643215 IC50 2.18 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCCN(C)C)cc4)cc3)nc21 CHEMBL590594 IC50 2.2 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(N3CCOCC3)ccnc21 CHEMBL1092768 IC50 2.2 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(C)=O)CC2)c(=O)n4C)cn1 CHEMBL2331661 Ki 2.2 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3905146 IC50 2.2 nM
CN(C)[C@@H]1C[C@@H](C(N)=O)N(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)C1 CHEMBL5079231 IC50 2.2 nM
NC(=O)[C@@H]1CC(O)CN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5084675 IC50 2.2 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCC#N)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645893 IC50 2.21 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCn4c(C)cnc4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645831 IC50 2.22 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4c(COC)nnc4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645837 IC50 2.22 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645983 IC50 2.23 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643216 IC50 2.24 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN(CC(F)F)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645874 IC50 2.27 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cn1 CHEMBL3681142 Ki 2.29 nM
CNC(=O)Nc1ccc(-c2nc(N3CCOC(C)C3)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL576143 IC50 2.3 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1)Nc1ccnnc1 CHEMBL599258 IC50 2.3 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4cccc(F)c4)c3)cc2s1 CHEMBL1773736 IC50 2.3 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@](C)(CC(C)(C)O)OC3)cc1 CHEMBL1774379 Ki 2.3 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CN(c2ncccn2)CC3)cc1 CHEMBL2181651 Ki 2.3 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC(C)(C)O)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645884 IC50 2.3 nM
O=C1OC[C@H](CC2CC2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653592 IC50 2.3 nM
O=C1OC[C@H](c2ccc(F)cc2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653622 IC50 2.3 nM
NC(=O)[C@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5091789 IC50 2.3 nM
COc1ncc(-c2ccc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3112720 IC50 2.32 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(C)nc5)nc4c32)CC1 CHEMBL2331662 Ki 2.33 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1 CHEMBL1097900 IC50 2.4 nM
CNC(=O)Nc1ccc2c(c1)C(=O)/C(=C\c1c(-c3c(C)nn(C)c3C)[nH]c3c(F)cc(OC)cc13)O2 CHEMBL1083305 IC50 2.4 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CN(c2cnccn2)CC3)cc1 CHEMBL2181653 Ki 2.4 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2ccnc(C)n2)C3)cc1 CHEMBL2331689 Ki 2.4 nM
CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4ncc[nH]4)cc3)c2n1 CHEMBL3650227 IC50 2.4 nM
O=C1OC[C@H](c2cccnc2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653596 IC50 2.4 nM
CSCC1(C)CN(c2ccc3oc(N)nc3c2)c2c(N)ncnc21 CHEMBL5220383 Ki 2.4 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCO3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645772 IC50 2.42 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@H](N(C)C)C3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645854 IC50 2.44 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccccc3)nc2n1 CHEMBL3688831 IC50 2.45 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(S(=O)(=O)CC)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645784 IC50 2.48 nM
CCc1ncnc(-c2cc(F)c(C(=O)N(C)C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643223 IC50 2.49 nM
C#CCN1CCN(C(=O)c2ccc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2F)CC1 CHEMBL3645839 IC50 2.49 nM
O=C(NCCF)Nc1ccc(-c2nc(C3=CCOCC3)c3sccc3n2)cc1 CHEMBL590356 IC50 2.5 nM
COC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL599259 IC50 2.5 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N6CCOCC6)cc5)cc4C3=O)c2c1 CHEMBL1082620 IC50 2.5 nM
COc1ccc(-c2ccc3c(N4CCOCC4)nc(N4C[C@@H](C)O[C@@H](C)C4)nc3n2)cc1CO CHEMBL1078983 IC50 2.5 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[S+]([O-])CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643145 IC50 2.5 nM
O=C1OC[C@H](c2ccccc2)N1c1ccn2ncc(-c3ccc(-c4ncc[nH]4)cc3)c2n1 CHEMBL3650230 IC50 2.5 nM
CC(C)[C@H]1CN(CCO)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653538 IC50 2.5 nM
Cc1cc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)ncc1F CHEMBL3653641 IC50 2.5 nM
Nc1ccc(-c2ccc3ncc4c(=O)[nH]c(=O)n(-c5cccc(C(F)(F)F)c5)c4c3n2)cn1 CHEMBL3903725 IC50 2.5 nM
C[C@@H]1COCCN1c1nc(-c2cnc(N)nc2)nc2c1C[C@@H]1COCCN21 CHEMBL4436124 Ki 2.5 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN4CCC[C@H]4C3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645879 IC50 2.51 nM
COCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc(OC)nc5)nc4c32)CC1 CHEMBL3681098 Ki 2.52 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCC(N)=O)CC3)c2=O)cn1 CHEMBL2375964 Ki 2.54 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)OC)cc4)cc3)nc21 CHEMBL592063 IC50 2.55 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1)NC1CC1 CHEMBL1097895 IC50 2.6 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3c(n2)C(C)(C)OC3=O)cc1 CHEMBL1774354 Ki 2.6 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)[C@H]2CC[C@@H](C3)N2S(C)(=O)=O)cc1 CHEMBL2334758 Ki 2.6 nM
O=C1OC[C@H](c2ccc(C(F)(F)F)cn2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653624 IC50 2.6 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc4c(c3)C(=O)NC4)nc2n1 CHEMBL3688936 IC50 2.6 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCNCC4)nc3n2)cc1CO CHEMBL3693523 IC50 2.6 nM
C[C@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cccc6[nH]ncc56)nc4c32)CC1 CHEMBL2331669 Ki 2.63 nM
CCc1ncnc(-c2ccc(C(=O)N(C)C3CCS(=O)(=O)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643271 IC50 2.64 nM
Nc1ncc(-c2ccc3ncc4c(=O)[nH]c(=O)n(-c5cccc(C(F)(F)F)c5)c4c3n2)cn1 CHEMBL3958025 IC50 2.66 nM
CCOC(=O)N1CCN(C(=O)c2ccc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2C)CC1 CHEMBL3645785 IC50 2.68 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCC(O)C3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643280 IC50 2.69 nM
CN(C)CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)nc21 CHEMBL565808 IC50 2.7 nM
CCCCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4nnn(CC)c4n3)cc2)cc1 CHEMBL589412 IC50 2.7 nM
NC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1 CHEMBL1098305 IC50 2.7 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2cc(C)ncn2)C3)cc1 CHEMBL2331676 Ki 2.7 nM
O=C(NCCF)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(c2ncccn2)C3)cc1 CHEMBL2331682 Ki 2.7 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCCS(C)(=O)=O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645928 IC50 2.7 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)COC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645957 IC50 2.7 nM
CC(C)[C@H]1CN(C[C@H](O)CO)C(=O)N1c1ccn2ncc(-c3ccc(-c4ncc[nH]4)cc3)c2n1 CHEMBL3653533 IC50 2.7 nM
O=C1OC[C@H](c2ccc(F)cn2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653626 IC50 2.7 nM
COc1cccc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)n1 CHEMBL3653637 IC50 2.7 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(C#N)cc3)nc2n1 CHEMBL3688886 IC50 2.7 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)C)CC3)c(C(F)(F)F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645902 IC50 2.72 nM
CN1CCN(c2ccnc3c2c(/C=C2\Oc4cccc(O)c4C2=O)cn3C)CC1 CHEMBL1090383 IC50 2.75 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4COC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645942 IC50 2.75 nM
CCc1ncnc(-c2ccc(C(=O)N3CCOCC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645770 IC50 2.79 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643232 IC50 2.8 nM
CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(Cl)c3)c2n1 CHEMBL3653569 IC50 2.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCN(C)CC4)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645856 IC50 2.81 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645882 IC50 2.84 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)C[C@@H]3C)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648884 IC50 2.84 nM
CNC(=O)Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CCO)c3n2)cc1 CHEMBL602682 IC50 2.85 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)CC3)c(Cl)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645864 IC50 2.86 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@H](N(C)C)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643268 IC50 2.87 nM
CCc1ncnc(-c2ccc(C(=O)N(C)OC)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645782 IC50 2.87 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C)C(=O)C3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645880 IC50 2.87 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3c(n2)[C@@](C)(CCO)OC3)cc1 CHEMBL1774367 Ki 2.9 nM
C[C@H]1COCCN1c1nc(-c2ccc(Nc3nn(C)c(=O)[nH]3)cc2)nc2c1CCN(c1ncccn1)C2 CHEMBL2331684 Ki 2.9 nM
Cn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)nc21 CHEMBL589599 IC50 2.95 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCCC[C@H]4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645818 IC50 2.98 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccs4)cc3)nc21 CHEMBL590084 IC50 3.0 nM
CN(C)CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)nc21 CHEMBL1092547 IC50 3.0 nM
O=CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL1091130 IC50 3.0 nM
COc1ccc2[nH]c(C)c(/C=C3\Oc4cc(O)cc(O)c4C3=O)c2c1 CHEMBL1088835 IC50 3.0 nM
CC(C)n1nc(-c2ccc(O)c(F)c2)c2c(N)ncnc21 CHEMBL1241945 IC50 3.0 nM
COc1ccc(-c2nn(C(C)C)c3ncnc(N)c23)cc1O CHEMBL1242114 IC50 3.0 nM
Cc1cc(C(=O)Nc2ccn[nH]2)c2nc(C)nc(N)c2c1 CHEMBL1668266 Ki 3.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3sc(C(C)(C)O)cc3n2)cc1 CHEMBL1774349 Ki 3.0 nM
C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3COC3)cc2)nc2c1COC2(C)C CHEMBL1774357 Ki 3.0 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(OC5COC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1808984 IC50 3.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 3.0 nM
COc1cnnc(Nc2cc(-c3c(Nc4cc[nH]n4)nc4cccnn34)nc(C)n2)c1 CHEMBL2172635 IC50 3.0 nM
CC(=O)Nc1cc(-c2c(Nc3cc[nH]n3)nc3cccnn23)nc(C)n1 CHEMBL2172629 IC50 3.0 nM
Cc1cc(-c2ccc3nc(Nc4cc[nH]n4)c(-c4nc(C)nc(N)n4)n3c2)on1 CHEMBL2172490 IC50 3.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4cncnc4C)cn23)n1 CHEMBL2172486 IC50 3.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4cccnc4C)cn23)n1 CHEMBL2172480 IC50 3.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4cccnc4)cn23)n1 CHEMBL2172636 IC50 3.0 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CN(c2ncccn2)C3)cc1 CHEMBL2181664 Ki 3.0 nM
CO[C@H]1CC[C@@H](CN2C(=O)CNc3ncc(-c4ccc(-c5nc[nH]n5)nc4C)nc32)CC1 CHEMBL3586561 IC50 3.0 nM
Cc1ncnc(N2CCC(O)(C(F)(F)F)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670171 IC50 3.0 nM
CNC(=O)c1ccc(-c2ncnc(C)c2C#Cc2ccc(N)nc2)cc1Cl CHEMBL3640929 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCCOC)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640976 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(F)F)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640987 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640990 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCCOC)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641004 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)NCCOC)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641007 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(c4ccccn4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641011 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)(C)C)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641022 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643063 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCO)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643067 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCN(C)CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643072 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643078 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643092 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[S+]([O-])CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643112 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643126 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC[C@H]3CO)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643140 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCC(O)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643150 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643159 IC50 3.0 nM
COCCN1CCN(C(=O)c2ccc(-c3ncnc(C)c3C#Cc3ccc(N)nc3)cc2)CC1 CHEMBL3643164 IC50 3.0 nM
Cc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3643168 IC50 3.0 nM
Cc1ncnc(-c2ccc(C(=O)N3CCN(CCO)CC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3643169 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)NC3CC(N4CCN(C)CC4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643172 IC50 3.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643212 IC50 3.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701062 IC50 3.0 nM
Cc1nccc(-c2ccc(C(=O)N(C)C)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3701066 IC50 3.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701076 IC50 3.0 nM
CCc1nccc(-c2ccc(C(=O)N(C)CCOC)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701090 IC50 3.0 nM
Cc1nccc(-c2ccc(F)c(C(=O)N(C)CCO)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701111 IC50 3.0 nM
Cc1nccc(-c2ccc(F)c(C(=O)N(C)CCCO)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701112 IC50 3.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCC(OC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701129 IC50 3.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN4CCCC4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701142 IC50 3.0 nM
Cc1nc(N)ccc1C#Cc1c(-c2ccc(C(=O)N3CCN(C)CC3)c(F)c2)ccnc1C CHEMBL3701162 IC50 3.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCNC(=O)C3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701181 IC50 3.0 nM
NC(=O)CN1CCC(n2c(=O)cnc3cnc4ccc(-c5ccc(N)nc5)cc4c32)CC1 CHEMBL4075931 IC50 3.0 nM
N#CCN1CCC(n2c(=O)cnc3cnc4ccc(-c5cnc6ccccc6c5)cc4c32)CC1 CHEMBL4096248 IC50 3.0 nM
N#CCN1CCC(n2c(=O)cnc3cnc4cc(F)c(-c5cn[nH]c5)cc4c32)CC1 CHEMBL4101340 IC50 3.0 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL521851 IC50 3.0 nM
NC(=O)C1CCCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5079887 IC50 3.0 nM
CN1CCC(NC(=O)c2ccc(-c3ccc(-n4c(=O)ccc5cnc6ccc(-c7cnc8ccccc8c7)cc6c54)cc3C(F)(F)F)cc2)CC1 CHEMBL1795875 IC50 3.01 nM
CNC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681122 Ki 3.01 nM
COc1ncc(-c2cc3c(-c4ccncc4)ccnc3cn2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577910 IC50 3.04 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CC4)c3n2)cc1)Nc1cccs1 CHEMBL601073 IC50 3.05 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C4COC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645946 IC50 3.07 nM
CN1CCN(C(=O)C2CCN(c3ccnc4c3c(/C=C3\Oc5cccc(O)c5C3=O)cn4C)CC2)CC1 CHEMBL1092486 IC50 3.1 nM
CNCCOc1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(OC)c(CO)c3)nc2n1 CHEMBL3693549 IC50 3.1 nM
CCN1CCN(C(=O)Nc2ccc(-c3nc(N4CCOCC4)c4cnn(CCCCCCC(=O)NO)c4n3)cc2)CC1 CHEMBL4437811 IC50 3.1 nM
CN(C)[C@H]1C[C@@H](C(N)=O)N(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)C1 CHEMBL5071429 IC50 3.1 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645851 IC50 3.11 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5395998 IC50 3.12 nM
CC(=O)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 CHEMBL5220911 IC50 3.13 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(c4ccccc4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645813 IC50 3.15 nM
C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NCCC#N)cc2)nc2c1COC2(C)C CHEMBL1774356 Ki 3.2 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@@](C)(CC(C)(C)O)OC3)cc1 CHEMBL1774381 Ki 3.2 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2ncc(F)cn2)C3)cc1 CHEMBL2331688 Ki 3.2 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C=O)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645891 IC50 3.2 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1C(N)=O CHEMBL2336320 IC50 3.2 nM
COc1ncc(-c2ccc3nccc(/C=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4789813 IC50 3.2 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N(C)C)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645781 IC50 3.23 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCC(C)(O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645875 IC50 3.29 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL3681110 Ki 3.29 nM
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@H](n3cnnn3)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C CHEMBL219410 IC50 3.3 nM
CCNC(=O)Nc1ccc(-c2nc(C3=CCOCC3)c3sccc3n2)cc1 CHEMBL600447 IC50 3.3 nM
N#Cc1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1257716 IC50 3.3 nM
CC[C@@H](C)[C@H]1O[C@]2(CC[C@H]1C)C[C@@H]1C[C@@H](CC=C(C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)C=CC=C3CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2 CHEMBL3349014 Potency 3.3 nM
Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922094 Kd 3.3 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCOCC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4758904 IC50 3.3 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnc3ccc-2cn13 CHEMBL4864407 IC50 3.3 nM
NC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5071942 IC50 3.3 nM
COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5089561 IC50 3.3 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5440263 IC50 3.31 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681082 Ki 3.32 nM
N[C@H]1CC[C@H](n2c(=O)[nH]c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681120 Ki 3.33 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](N(C)C)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643269 IC50 3.38 nM
Cc1cccc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)n1 CHEMBL3653599 IC50 3.4 nM
Nc1cc(C(F)F)c(-c2nc(N3CCOCC3)nc(N3CC4CCC(C3)O4)n2)cn1 CHEMBL4279881 Ki 3.4 nM
CN1CCN(C(=O)Nc2ccc(-c3nc(N4CCOCC4)c4cnn(CCCCCCC(=O)NO)c4n3)cc2)CC1 CHEMBL4582850 IC50 3.4 nM
CCc1ncnc(-c2cc(F)c(C(=O)NC)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643225 IC50 3.42 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)C[C@H]3C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648887 IC50 3.42 nM
CN(C)CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681073 Ki 3.42 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cc1 CHEMBL3681188 Ki 3.42 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCOCC4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645769 IC50 3.43 nM
CCc1ncnc(-c2ccc(C(=O)NC3CCCN(C)C3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645798 IC50 3.43 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C(C)(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645857 IC50 3.43 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccccc3)ccnc21 CHEMBL1090043 IC50 3.45 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1)Nc1ccc(-c2cccnc2)nc1 CHEMBL1255816 IC50 3.45 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(C(C)(C)O)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645886 IC50 3.49 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2nc(C)ns2)C3)cc1 CHEMBL2181526 Ki 3.5 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCCCC4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645787 IC50 3.5 nM
O=C1OC[C@H](C2CCCCC2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653573 IC50 3.5 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc4c(c3)NC(=O)C4)nc2n1 CHEMBL3688941 IC50 3.5 nM
C[C@@H]1COC[C@H](C)N1c1nc(-c2cnc(N)cc2C(F)F)nc(N2[C@H](C)COC[C@@H]2C)n1 CHEMBL4277247 Ki 3.5 nM
Nc1ccc(-c2nc(N3C4CCC3COC4)c3c(n2)N2CCOC[C@H]2C3)cn1 CHEMBL4574759 Kd 3.5 nM
C[C@@H]1COCCN1c1nc(-c2cnc(N)cn2)nc2c1C[C@@H]1COCCN21 CHEMBL4551080 Kd 3.5 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CCO)CC2)c(=O)n4C)cn1 CHEMBL3681124 Ki 3.52 nM
N=C(N)NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4ncccc4n3)cc2)cc1 CHEMBL4104902 IC50 3.57 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645883 IC50 3.58 nM
CCOC(=O)N1CCN(C(=O)c2ccc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2Cl)CC1 CHEMBL3643273 IC50 3.59 nM
CN(C)CCC(=O)N1CCN(c2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc2C(F)(F)F)CC1 CHEMBL1256457 IC50 3.6 nM
C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC[C@@H](O)CO)cc2)nc2c1COC2(C)C CHEMBL1774359 Ki 3.6 nM
COc1ncc(-c2ccc3c(c2)N(C(C)C)C(=O)CO3)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL4529195 IC50 3.6 nM
Cn1c(=O)n(C2CCNCC2)c2c3nc(-c4cnc(N)nc4)ccc3ncc21 CHEMBL3681153 Ki 3.61 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C(C)(C)O)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643277 IC50 3.64 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCC#CCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5415288 IC50 3.65 nM
CN1CCN(Cc2cc3nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc(N4CC5CCC(C4)O5)c3s2)CC1 CHEMBL594173 IC50 3.7 nM
Cn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccs4)cc3)nc21 CHEMBL589600 IC50 3.7 nM
C/C=C(/C)C(=O)O[C@H]1C(C)=C2[C@H]([C@@H]1OC(=O)CCCCCCC)[C@@](C)(OC(C)=O)C[C@H](OC(=O)CCC)[C@@]1(O)[C@H]2OC(=O)[C@@]1(C)O CHEMBL96926 Potency 3.7 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CN(S(C)(=O)=O)C3)cc1 CHEMBL2181665 Ki 3.7 nM
O=C(Nc1ccc(C(=O)N2CCCC2C(=O)O)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL5094579 IC50 3.7 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(C)=O)CC2)c(=O)n4C)cn1 CHEMBL3681117 Ki 3.74 nM
Nc1nc2cc(-c3nn(CCCCC(=O)NO)c4ncnc(N)c34)ccc2o1 CHEMBL4863909 IC50 3.76 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN(C)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645869 IC50 3.78 nM
CCc1ncnc(-c2cc(F)c(C(=O)NCCN3CCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643226 IC50 3.79 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N6CCN(C)CC6)cc5)cc4C3=O)c2c1 CHEMBL1082618 IC50 3.8 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(C2COC2)C3)cc1 CHEMBL2331680 Ki 3.8 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3963018 IC50 3.8 nM
CCc1ncnc(-c2ccc(C(=O)NCCN3CCOCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643274 IC50 3.8 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CC4(CN(C)C4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645954 IC50 3.8 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681089 Ki 3.8 nM
CCN(CC)CCCNCc1cc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)ccc1OC CHEMBL3689032 IC50 3.8 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C4COC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645948 IC50 3.83 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CN)CC2)c(=O)n4C)cn1 CHEMBL3681111 Ki 3.84 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL604908 IC50 3.9 nM
O=C(Nc1ccc(F)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL599246 IC50 3.9 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCOCC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1738719 IC50 3.9 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCN(Cc5ccncc5)CC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914724 IC50 3.9 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CCN(C=O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645876 IC50 3.92 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](O)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643149 IC50 3.94 nM
O=C(c1ccccc1)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4cccc(O)c4)nc32)CC1 CHEMBL575710 IC50 4.0 nM
O=C(c1cccnc1)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc5[nH]ccc5c4)nc32)CC1 CHEMBL576768 IC50 4.0 nM
Cc1c(-c2cccc(S(C)(=O)=O)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1091977 Ki 4.0 nM
Cc1c(-c2cccc(C(=O)N3CCN(C)CC3)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1093267 Ki 4.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2C CHEMBL1089653 IC50 4.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@@](C)(CCO)OC3)cc1 CHEMBL1774366 Ki 4.0 nM
Cc1cc(-c2ccc3nc(Nc4cc[nH]n4)c(-c4nc(C)nc(N)n4)n3c2)ccn1 CHEMBL2172484 IC50 4.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3CC)c3c(ncn3C)n2)cc1 CHEMBL2418344 Ki 4.0 nM
O=C1CNc2ncc(-c3ccc(-c4nc[nH]n4)cc3)nc2N1CCC1CCOCC1 CHEMBL3586382 IC50 4.0 nM
Cc1cc(-c2nc[nH]n2)ccc1-c1cnc2c(n1)N(CCC1CCOCC1)CC(=O)N2 CHEMBL3586383 IC50 4.0 nM
CCc1ncnc(N2CCC3(CC2)OCCO3)c1C#Cc1ccc(N)nc1 CHEMBL3670161 IC50 4.0 nM
CCc1ncnc(N2CCC(O)(CC)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670173 IC50 4.0 nM
CCc1ncnc(N2CCC3(CC2)OCCCO3)c1C#Cc1ccc(N)nc1 CHEMBL3670199 IC50 4.0 nM
Cc1ncnc(-c2ccc(Cl)c(C(=O)N3CCOCC3)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640965 IC50 4.0 nM
CCc1ncnc(-c2ccc(Cl)c(C(=O)N(C)C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640970 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCCC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640985 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640988 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641012 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643064 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)O)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643077 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CC(C)(C)O)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643089 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)=O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3643090 IC50 4.0 nM
CCCCN1CCN(C(=O)c2ccc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2F)CC1 CHEMBL3643091 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCS(=O)(=O)C4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643094 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC4CCCO4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643096 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCO)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643099 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(O)(CC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643130 IC50 4.0 nM
Cc1ncnc(-c2ccc(C(=O)N3CCN(c4ccccc4)CC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3643163 IC50 4.0 nM
Cc1ncnc(-c2ccc(C(=O)N3CCN(C4CCS(=O)(=O)C4)CC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3643167 IC50 4.0 nM
Cc1ncnc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3643170 IC50 4.0 nM
CCc1ncnc(-c2ccc(C(=O)NCCN3CCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643190 IC50 4.0 nM
Cc1cc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)cc4)c3n2)ncc1F CHEMBL3653642 IC50 4.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701059 IC50 4.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701061 IC50 4.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCNCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701077 IC50 4.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701086 IC50 4.0 nM
Cc1ccc(C#Cc2c(-c3ccc(Cl)c(C(=O)N4CCOCC4)c3)ccnc2C)cn1 CHEMBL3701093 IC50 4.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701099 IC50 4.0 nM
CCc1nccc(-c2ccc(C(=O)NC)c(Cl)c2)c1C#Cc1ccc(N)nc1C CHEMBL3701139 IC50 4.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN4CCCCC4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701141 IC50 4.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C4COC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701155 IC50 4.0 nM
Cc1nc(N)ccc1C#Cc1c(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)ccnc1C CHEMBL3701163 IC50 4.0 nM
NC(=O)N1CCC(n2c(=O)cnc3cnc4ccc(-c5ccc(N)nc5)cc4c32)CC1 CHEMBL4083691 IC50 4.0 nM
COC(=O)CN1CCC(n2c(=O)cnc3cnc4ccc(-c5ccc(N)nc5)cc4c32)CC1 CHEMBL4064699 IC50 4.0 nM
CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)nc(N)nc21 CHEMBL4529672 Ki 4.0 nM
COc1cccc2cc(-c3nc(C4CCC(C(=O)O)CC4)n4ncnc(N)c34)[nH]c12 CHEMBL2132692 IC50 4.0 nM
CCNC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681071 Ki 4.04 nM
CNC(=O)CCCCCCCn1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc21 CHEMBL4870348 IC50 4.05 nM
Cn1c(=O)n(C2CCN(C(=O)CO)CC2)c2c3nc(-c4cnc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681178 Ki 4.06 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCC1CCN(CC1)c1ccnc3ccc-2cc13 CHEMBL4866790 IC50 4.1 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCOCC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645811 IC50 4.16 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N6CCOCC6)cc5)cc4C3=O)c2c1 CHEMBL1082617 IC50 4.2 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)[C@@H]2CC[C@H](C3)N2C)cc1 CHEMBL2334754 Ki 4.2 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)[C@H]2CC[C@@H](C3)N2C)cc1 CHEMBL2334753 Ki 4.2 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(S(C)(=O)=O)C3)cc1 CHEMBL2331679 Ki 4.2 nM
O=C1OC[C@H](c2ccccc2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653576 IC50 4.2 nM
COC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5086369 IC50 4.2 nM
Nc1nc2cc(-c3nn(CCCC(=O)NCCCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5436508 IC50 4.2 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4COC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645944 IC50 4.24 nM
O=C(CN1CCOCC1)N1CCC(c2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc2C(F)(F)F)CC1 CHEMBL1256462 IC50 4.25 nM
CN(C)c1ccc(-c2ccc3ncc4[nH]c(=O)n(-c5ccc(C(C)(C)C#N)cc5)c4c3n2)cn1 CHEMBL3681056 Ki 4.26 nM
COC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)OC)CC4)c3n2)cc1 CHEMBL561708 IC50 4.3 nM
CCOC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681074 Ki 4.3 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(NS(=O)(=O)CCO)c3)nc2n1 CHEMBL3693445 IC50 4.3 nM
CC(C)N1C(=O)COc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc21 CHEMBL4452675 IC50 4.3 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(CO)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645892 IC50 4.33 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCCS(C)(=O)=O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645921 IC50 4.36 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C)C[C@@H]3C)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648881 IC50 4.36 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)C(C)(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681131 Ki 4.38 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3c(n2)[C@](C)(CO)OC3)cc1 CHEMBL1774376 Ki 4.4 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2nnc(C)o2)C3)cc1 CHEMBL2181527 Ki 4.4 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCN3CCCC3=O)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643275 IC50 4.4 nM
O=C1OC[C@H](C2CCOCC2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653594 IC50 4.4 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(O)cc3)nc2n1 CHEMBL3688832 IC50 4.4 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cccc(c1)Cc1cnc3sc-2nn13 CHEMBL4853785 IC50 4.4 nM
CCc1ncnc(-c2ccc(C(=O)N3C[C@H]4CN(C(=O)OC(C)(C)C)C[C@H]4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648869 IC50 4.43 nM
C[C@H](CO)n1c(=O)n(C)c2cnc3ccc(-c4c[nH]c5nncc-5c4)nc3c21 CHEMBL3681162 Ki 4.44 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCO)CC3)c2=O)cn1 CHEMBL2376093 Ki 4.46 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C(C)(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643230 IC50 4.5 nM
O=C1OC[C@H](C2CC2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653593 IC50 4.5 nM
Nc1nnc(-c2ccc(-c3cnn4ccc(N5C(=O)OC[C@@H]5c5ccc(F)cc5)nc34)cc2)o1 CHEMBL3653649 IC50 4.5 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(-c2ccc(C(C)(C)C#N)cc2)c(=O)n4C)cn1 CHEMBL2331657 Ki 4.51 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CCN(C)C4)C3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645790 IC50 4.51 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(C)CC2)c(=O)n4C)cn1 CHEMBL3681113 Ki 4.51 nM
Cc1nc(N)nc2c1cc(-c1cn[nH]c1)c(=O)n2[C@H]1CC[C@@H](OCC(N)=O)CC1 CHEMBL2375962 Ki 4.52 nM
CCCCN1CCN(C(=O)c2ccc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2OC)CC1 CHEMBL3643234 IC50 4.52 nM
CCn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)N4CCN(CCO)CC4)cc3)ccnc21 CHEMBL1088745 IC50 4.55 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCOCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643160 IC50 4.57 nM
COC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5cccnc5)CC4)c3n2)cc1 CHEMBL561103 IC50 4.6 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(N)cc4)nc32)CC1 CHEMBL1095626 IC50 4.6 nM
Cc1nc(-c2ccc(-c3cnn4ccc(N5C(=O)OC[C@@H]5c5ccc(F)cc5)nc34)cc2)n[nH]1 CHEMBL3653603 IC50 4.6 nM
C[C@@H]1CN(c2nc(N3CCOC[C@@H]3C)c3ccc(-c4ccc(CO)cc4)nc3n2)C[C@H](C)O1 CHEMBL3688899 IC50 4.6 nM
CCc1ncnc(-c2cc(F)c(C(=O)N(C)C3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645849 IC50 4.63 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccnc6[nH]ncc56)nc4c32)CC1 CHEMBL3681171 Ki 4.63 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(-c2ccc(C(C)(C)C#N)cc2)c(=O)n4C)cn1 CHEMBL3681057 Ki 4.67 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(F)F)CC3)c(Cl)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645860 IC50 4.69 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(C)(O)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645890 IC50 4.69 nM
CN1CCN(Cc2cc3nc(-c4ccc(NC(=O)Nc5cccnc5)cc4)nc(N4CC5CCC(C4)O5)c3s2)CC1 CHEMBL594606 IC50 4.7 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3c(n2)[C@@](C)(CC(C)(C)O)OC3)cc1 CHEMBL1774382 Ki 4.7 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645855 IC50 4.7 nM
CC(C)[C@H]1CNC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653539 IC50 4.7 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(C(=O)NCCF)c3)nc2n1 CHEMBL3688962 IC50 4.7 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N(CCO)C(C)C)nc3n2)cc1CO CHEMBL3693540 IC50 4.7 nM
COc1ncc(-c2ccc3ncc(Cl)c(=O)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4288258 IC50 4.7 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cccc(c1)-c1ncnc3sc-2cc13 CHEMBL4875080 IC50 4.7 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](OCCO)CC2)c(=O)n4C)cn1 CHEMBL2331658 Ki 4.71 nM
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@H](n3ncnn3)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C CHEMBL439319 IC50 4.8 nM
CC(C)NC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5ccccc5)CC4)c3n2)cc1 CHEMBL1097894 IC50 4.8 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(C2CCCC2)C3)cc1 CHEMBL2331558 Ki 4.8 nM
CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3650231 IC50 4.8 nM
C[C@H]1COCCN1c1nc(N2CCOCC2)nc2nc(-c3cccc(NS(C)(=O)=O)c3)ccc12 CHEMBL3688947 IC50 4.8 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5C[C@@H]6OCCO[C@H]6C5)n4)cc3)cc2)CC1 CHEMBL5079397 IC50 4.8 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cccc(-n6cccn6)c5)nc4c32)CC1 CHEMBL3681169 Ki 4.82 nM
CCc1ncnc(-c2ccc(C(=O)N(C)C3CCS(=O)(=O)C3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643252 IC50 4.84 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCN(C)CC4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643279 IC50 4.84 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)CN(C)C4)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648878 IC50 4.85 nM
CC(C)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681072 Ki 4.87 nM
CN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681076 Ki 4.9 nM
O=C1OC[C@H](c2ccc(F)cc2)N1c1ccn2ncc(-c3ccc(-c4cc[nH]n4)cc3)c2n1 CHEMBL3653646 IC50 4.9 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc4c(c3)NCCNC4=O)nc2n1 CHEMBL3693589 IC50 4.9 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1ncnc3ccc-2cc13 CHEMBL4872630 IC50 4.9 nM
CNC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681070 Ki 4.91 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643260 IC50 4.95 nM
CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C(\C)[C@@H](c3cccc4c(C)c[nH]c34)C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)CC[C@H]1O CHEMBL503885 IC50 5.0 nM
CS(=O)(=O)c1cccc(-c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)c1 CHEMBL1090601 Ki 5.0 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C(C)C)c2=O)cn1 CHEMBL1258458 Ki 5.0 nM
Cc1ccc(-c2nc3c(C)nc(N)nc3n(C3CCOCC3)c2=O)cn1 CHEMBL1257178 Ki 5.0 nM
Cc1nc(N)c2cccc(C(=O)Nc3cnc4[nH]ccc4c3)c2n1 CHEMBL1668275 Ki 5.0 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914743 IC50 5.0 nM
O=c1[nH]c2ncc(-c3ccc(-c4ncc[nH]4)cc3)nc2n1CC1CCOCC1 CHEMBL1945955 IC50 5.0 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4C[C@H]5CC[C@@H](C4)O5)n2)CS(=O)(=O)CC3)cc1 CHEMBL2063759 Ki 5.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4cncn4C)cn23)n1 CHEMBL2172488 IC50 5.0 nM
O=C(Nc1ccc(CO)cc1)Nc1ccc(-c2nc(N3CCOCC3)c3ncccc3n2)cc1 CHEMBL3109142 IC50 5.0 nM
Cc1cc(-c2nc[nH]n2)ccc1-c1cnc2c(n1)N(CCC1CCOCC1)C(=O)CN2 CHEMBL3586384 IC50 5.0 nM
Nc1nc2cc(-c3nn(CC4CCCO4)c4ncnc(N)c34)ccc2o1 CHEMBL3797834 IC50 5.0 nM
CCc1ncnc(N2CCC(CCO)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670157 IC50 5.0 nM
CCC1(O)CCN(c2ncnc(C)c2C#Cc2ccc(N)nc2)CC1 CHEMBL3670175 IC50 5.0 nM
CCc1ncnc(N2CCC(C)(O)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670162 IC50 5.0 nM
CCc1ncnc(N2CCC(C)(OC)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670197 IC50 5.0 nM
Cc1ncnc(N2CCC(O)(C(C)C)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670203 IC50 5.0 nM
CCc1ncnc(N2CCC3(CC2)CC(=O)NC(=O)C3)c1C#Cc1ccc(N)nc1 CHEMBL3670219 IC50 5.0 nM
Cc1ncnc(-c2ccc(C(=O)N(C)C)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3640930 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)NC)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640936 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC4CCCO4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640991 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCN(C)C)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1C CHEMBL3641001 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(c4ccccc4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3641013 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCCCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643079 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCN(CC)CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643086 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)CCC3(O)CCCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643088 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(S(=O)(=O)CC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643097 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643113 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC[C@@H]3CO)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643136 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC4CC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643141 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)(C)O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643142 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)NCCN3CCCC3=O)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643184 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)NC3CCS(=O)(=O)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643185 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCO3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643191 IC50 5.0 nM
CCc1ncnc(-c2ccc(C(=O)N3C[C@@H]4CCN(C(=O)OC(C)(C)C)[C@@H]4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648871 IC50 5.0 nM
O=C1OCC(c2ccccn2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(Cl)c3)c2n1 CHEMBL3653620 IC50 5.0 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc(-c3cccc4[nH]ccc34)[nH]c2n1 CHEMBL3667436 IC50 5.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701058 IC50 5.0 nM
CCc1nccc(-c2ccc(C(=O)NC)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701070 IC50 5.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3701089 IC50 5.0 nM
Cc1nccc(-c2ccc(Cl)c(C(=O)N(C)C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701097 IC50 5.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C(C)(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701104 IC50 5.0 nM
Cc1nc(N)ccc1C#Cc1c(-c2ccc(S(C)(=O)=O)cc2)ccnc1C CHEMBL3701136 IC50 5.0 nM
CCc1nccc(-c2ccc(S(C)(=O)=O)cc2)c1C#Cc1ccc(N)nc1C CHEMBL3701138 IC50 5.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3701151 IC50 5.0 nM
COCCN1CCN(C(=O)c2ccc(-c3ccnc(C)c3C#Cc3ccc(N)nc3C)cc2F)CC1 CHEMBL3701164 IC50 5.0 nM
Cc1nc(N)ccc1C#Cc1c(-c2ccc(C(=O)N3CCN(C(C)(C)C)CC3)c(F)c2)ccnc1C CHEMBL3701165 IC50 5.0 nM
Cc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1 CHEMBL3688833 IC50 5.0 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccoc3)nc2n1 CHEMBL3688896 IC50 5.0 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4739883 IC50 5.0 nM
CC(C)n1nc(-c2ccc(Br)c(O)c2)c2c(N)ncnc21 CHEMBL1241578 IC50 5.0 nM
CCC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)OC)cc4)nc32)CC1 CHEMBL5291092 IC50 5.0 nM
Nc1cc(C(F)F)c(-c2nc(C3CCOCC3)nc(N3C4CCC3COC4)n2)cn1 CHEMBL5400572 Kd 5.0 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCO)CC3)c2=O)cn1 CHEMBL2375365 Ki 5.05 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)OCCCO4)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645795 IC50 5.09 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CN(C(=O)NCC)C3)cc1 CHEMBL2181528 Ki 5.1 nM
CC(C)[C@H]1CN(CCN2CC3CCC(C2)O3)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653548 IC50 5.1 nM
Cc1ccc(-c2nc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1 CHEMBL1258910 Ki 5.11 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@H](N(C)C)C3)c(Cl)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645863 IC50 5.16 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C(C)(C)O)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645850 IC50 5.19 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c2c1 CHEMBL1082986 IC50 5.2 nM
COCCN1C[C@H](C(C)C)N(c2ccn3ncc(-c4ccc(-c5ncc[nH]5)cc4)c3n2)C1=O CHEMBL3653530 IC50 5.2 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(C(=O)N4CC[C@@H](O)C4)c3)nc2n1 CHEMBL3688964 IC50 5.2 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCNC(=O)C4C)nc3n2)cc1CO CHEMBL3693536 IC50 5.2 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCC4(CC3)CN(C)C4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648876 IC50 5.21 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CC[C@@H](N(C)C)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645868 IC50 5.28 nM
CN1C2CCC1CC(Oc1nc(-c3ccc(NC(=O)Nc4ccc(C(N)=O)cc4)cc3)nc(N3CCOCC3)n1)C2 CHEMBL1808992 IC50 5.3 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCCN4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914736 IC50 5.3 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL573339 IC50 5.3 nM
CC(C)Nc1nc(-c2ccc(NC(=O)Nc3ccc(N4CCN(C)CC4)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1091345 IC50 5.4 nM
Cn1cc(/C=C2\Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(N3CCC(C(=O)N4C5CCC4COC5)CC3)ccnc21 CHEMBL1091697 IC50 5.4 nM
CC(=O)N1CCN(c2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc2C(F)(F)F)CC1 CHEMBL1256469 IC50 5.4 nM
COc1ncc(-c2ccc3nccc(C#CCN4CCN(S(C)(=O)=O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3763244 IC50 5.4 nM
CSc1c(-c2ccncc2)nc(-c2ccc(NC(=O)Nc3ccc(N4CCOCC4=O)cc3)cc2)nc1N1CCOCC1 CHEMBL3923593 IC50 5.4 nM
Cn1c(=O)c2cnc3ccc(-c4ccc(N)nc4)nc3c2n(-c2cccc(C(F)(F)F)c2)c1=O CHEMBL3973532 IC50 5.4 nM
COc1ncc2cc1NS(=O)(=O)c1cc(c(F)cc1F)C(=O)NCc1cncc(c1)-c1ccnc3ccc-2nc13 CHEMBL4875906 IC50 5.4 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645852 IC50 5.43 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCCC[C@H]4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645819 IC50 5.45 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)C[C@@H]3C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648888 IC50 5.46 nM
CNC(=O)Nc1ccc(-c2nc(N3C[C@@H]4C[C@H]3CO4)c3cnn(CC(F)(F)F)c3n2)cc1 CHEMBL566087 IC50 5.5 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(c2ncccn2)C3)cc1 CHEMBL2181661 Ki 5.5 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCSCC4)nc3n2)cc1C(N)=O CHEMBL3890706 IC50 5.5 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CC4(CN(C)C4)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645955 IC50 5.54 nM
CN(C)CCNC(=O)Nc1ccc2c(c1)C(=O)/C(=C/c1cn(C)c3nccc(N4CC5CCC(C4)O5)c13)O2 CHEMBL1092110 IC50 5.6 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)NCCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808980 IC50 5.6 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(CO)c3)nc2n1 CHEMBL3688836 IC50 5.6 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCCn1cc(cn1)-c1cnc3ccc-2nn13 CHEMBL4873529 IC50 5.6 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)C[C@H]3C)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648883 IC50 5.62 nM
CN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL3681179 Ki 5.67 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOCC4)nc3n2)cc1CO CHEMBL3688838 IC50 5.7 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N[C@H](C)C(N)=O)nc3n2)cc1CO CHEMBL3693537 IC50 5.7 nM
NC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4C[C@@H]5OCCO[C@H]5C4)n3)cc2)cc1 CHEMBL5078347 IC50 5.7 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CC[C@@H](N(C)C)C3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645881 IC50 5.71 nM
C[C@H]1COCCN1c1cc(CS(C)(=O)=O)nc(-c2ccc(NC(=O)NCCO)cc2)n1 CHEMBL3410548 pIC50 5.754 nM
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)OC([C@H](C)C[C@@H]2CC[C@@H](OC(=O)N(C)OC)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C CHEMBL269553 IC50 5.8 nM
CC(C)[C@H]1CN(CC2CCNCC2)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653565 IC50 5.8 nM
O=C1O[C@@H]2CCCC[C@@H]2N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653605 IC50 5.8 nM
CSc1c(-c2cccnc2)nc(-c2ccc(NC(=O)Nc3ccc(N4CCOCC4=O)cc3)cc2)nc1N1CCOCC1 CHEMBL3962107 IC50 5.8 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](C(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681096 Ki 5.85 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[S+]([O-])CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645799 IC50 5.86 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C)C[C@H]3C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648880 IC50 5.86 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C)(O)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643147 IC50 5.9 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)CC(N)C4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645986 IC50 5.95 nM
CC(COc1no[n+]([O-])c1S(=O)(=O)c1ccccc1)NC(=O)CCCn1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc21 CHEMBL5429700 IC50 5.96 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCNCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL5220248 IC50 5.97 nM
CCc1ncnc(-c2ccc(C(=O)NCCN3CCOCC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645788 IC50 5.98 nM
O=C(c1cccnc1)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4cccc(O)c4)nc32)CC1 CHEMBL575501 IC50 6.0 nM
CCn1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(N5CCCC5)cc4)cc3)nc21 CHEMBL585397 IC50 6.0 nM
Cc1nc(N)nc2c1nc(-c1ccn[nH]1)c(=O)n2C(C)C CHEMBL1258567 Ki 6.0 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3ccc4nc(NC(C)=O)sc4c3)cnc2C)cc1 CHEMBL1773603 IC50 6.0 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)COC3)cc1 CHEMBL1774352 Ki 6.0 nM
CNc1nc2cc(-c3cnc4[nH]c(=O)n(CC5CCOCC5)c4n3)ccc2[nH]1 CHEMBL1946265 IC50 6.0 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CS(=O)(=O)CC3)cc1 CHEMBL2063756 IC50 6.0 nM
Cc1nc(Nc2cnccn2)cc(-c2c(Nc3cc[nH]n3)nc3cccnn23)n1 CHEMBL2172630 IC50 6.0 nM
Cc1nc(N)nc(-c2c(Nc3cc[nH]n3)nc3ccc(-c4ccncc4)cn23)n1 CHEMBL2172640 IC50 6.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3CC)c3c(ccn3C)n2)cc1 CHEMBL2418347 Ki 6.0 nM
Cc1ncnc(N2CCC3(CC2)OCCCO3)c1C#Cc1ccc(N)nc1 CHEMBL3670198 IC50 6.0 nM
Cc1ncnc(-c2ccc(F)c(C(=O)N(C)C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640933 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)=O)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643098 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCOC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643103 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643104 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(CCO)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643111 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCC(O)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643116 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643127 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(OC)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643146 IC50 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCCCC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3639421 IC50 6.0 nM
C[C@@H]1COCCN1c1nc(N2CCOCC2)nc2[nH]c(-c3cccc4[nH]ccc34)nc12 CHEMBL3667434 IC50 6.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701081 IC50 6.0 nM
COCCN(C)C(=O)c1cc(-c2ccnc(C)c2C#Cc2ccc(N)nc2)ccc1Cl CHEMBL3701096 IC50 6.0 nM
COCCN(C)C(=O)c1cc(-c2ccnc(C)c2C#Cc2ccc(N)nc2)ccc1F CHEMBL3701101 IC50 6.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C)C(C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701147 IC50 6.0 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccncc3)nc2n1 CHEMBL3688868 IC50 6.0 nM
CN1CC(C)(C)Oc2nc(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O CHEMBL3943611 IC50 6.0 nM
CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2cnc(N)nc21 CHEMBL4564479 Ki 6.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CC4(CN(C)C4)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648874 IC50 6.07 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)C(C)(C)O)CC2)c(=O)n4C)cn1 CHEMBL3681135 Ki 6.1 nM
Cc1nnc(-c2ccc(-c3cnn4ccc(N5C(=O)OC[C@@H]5C(C)C)nc34)cc2)[nH]1 CHEMBL3650237 IC50 6.1 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCC(O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4750601 IC50 6.1 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4cc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL5070586 IC50 6.2 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL597814 IC50 6.3 nM
Cc1c(CN2CCN(C(=O)[C@H](C)N)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922091 Ki(app) 6.3 nM
Nc1nnc(-c2ccc(-c3cnn4ccc(N5C(=O)OC[C@@H]5c5ccc(F)cn5)nc34)cc2F)o1 CHEMBL3653654 IC50 6.3 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N(C)CCO)nc3n2)cc1CO CHEMBL3693539 IC50 6.3 nM
C[C@@]12COCCN1c1nc(-c3ccc(NC(=O)NC4CC4)cc3)ncc1N(CC1CC1)C2=O CHEMBL4540705 pIC50 6.31 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)C(C)(C)S(=O)(=O)C3)cc1 CHEMBL4577549 pKd(app) 6.31 nM
CCc1ncnc(-c2ccc(C(=O)N3CCOCC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643239 IC50 6.34 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL3681104 Ki 6.39 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCCCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5404075 IC50 6.39 nM
CCC[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653588 IC50 6.4 nM
Cc1csc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)n1 CHEMBL3653597 IC50 6.4 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4C[C@@H](C)O[C@@H](C)C4)nc3n2)cc1F CHEMBL3688903 IC50 6.4 nM
C[C@@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)F)nc(N2[C@@H](C)COC[C@@H]2C)n1 CHEMBL4777159 Ki 6.4 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681127 Ki 6.42 nM
CCc1ncnc(-c2ccc(C(=O)N(C)OC)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643251 IC50 6.43 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)CNCCO4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645988 IC50 6.48 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2ccccc2)C3)cc1 CHEMBL2181658 Ki 6.5 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)C[C@H]2CC[C@@H]3N2C)cc1 CHEMBL2334762 Ki 6.5 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)[C@H]2CC[C@@H](C3)N2CC)cc1 CHEMBL2334755 Ki 6.5 nM
CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nnc(N)o4)cc3)c2n1 CHEMBL3650235 IC50 6.5 nM
Cc1nc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)cs1 CHEMBL3653602 IC50 6.5 nM
Cc1ccc(F)c([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)n1 CHEMBL3653648 IC50 6.5 nM
Cn1c(=O)n(C2CCC(C(=O)OCc3ccccc3)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681065 Ki 6.53 nM
CC(C)N(C)c1nc(-c2ccc(NC(=O)Nc3ccc(N4CCN(C)CC4)cc3)cc2)nc(N2C3CCC2COC3)n1 CHEMBL1091346 IC50 6.6 nM
CC(=O)Nc1cn2cc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 CHEMBL1822057 IC50 6.6 nM
O=c1cccc(Nc2ccc(-c3nc4c(c(N5CCOCC5)n3)CCN(c3ncccn3)C4)cc2)[nH]1 CHEMBL2331686 Ki 6.6 nM
CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nnc(N)s4)cc3)c2n1 CHEMBL3650236 IC50 6.6 nM
COCC1(C)COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653633 IC50 6.6 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C)(O)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645800 IC50 6.62 nM
CCc1ncnc(-c2ccc(C(=O)N3CC(O)CO3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643240 IC50 6.64 nM
C[C@H](CO)n1c(=O)n(C)c2cnc3ccc(-c4cccc5[nH]ccc45)nc3c21 CHEMBL3681161 Ki 6.66 nM
O=C(Nc1ccc(Cl)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL604303 IC50 6.7 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOCC4)nc3n2)cc1C(N)=O CHEMBL3916652 IC50 6.7 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCCCCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5423546 IC50 6.71 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CCN)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645952 IC50 6.76 nM
NOCCOCCOCCOCCC(=O)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 CHEMBL5219247 IC50 6.77 nM
COc1ccc(-c2nc3c(C)nc(N)nc3n([C@H]3CC[C@H](O)CC3)c2=O)cn1 CHEMBL1257177 Ki 6.8 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@@](C)(CO)OC3)cc1 CHEMBL1774377 Ki 6.8 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CN(S(C)(=O)=O)CC3)cc1 CHEMBL2181648 Ki 6.8 nM
CCc1ncnc(-c2ccc(C(=O)NCC3CCNCC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645842 IC50 6.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCCC4)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643259 IC50 6.82 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645793 IC50 6.82 nM
O=C(C1CC1)N1CCN(c2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc2C(F)(F)F)CC1 CHEMBL1256456 IC50 6.84 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(O)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645810 IC50 6.85 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(N)cc3)nc2n1 CHEMBL3958903 IC50 6.865 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(F)c(C(=O)O)c3)nc2n1 CHEMBL3688855 IC50 6.9 nM
Nc1cc(C(F)F)c(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cn1 CHEMBL4280087 Ki 6.9 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(C4CCN(C)CC4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643143 IC50 6.99 nM
CCc1ncnc(-c2ccc(C(=O)NCC3(C)COC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643161 IC50 6.99 nM
C[C@H](CO)n1c(=O)n(C)c2cnc3ccc(-c4cnc(N)nc4)nc3c21 CHEMBL3681159 Ki 6.99 nM
CC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5cccnc5)CC4)c3n2)cc1 CHEMBL561844 IC50 7.0 nM
CN(C)CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccccn4)cc3)nc21 CHEMBL1092546 IC50 7.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CCN4CCCC4)c3n2)cc1 CHEMBL1089428 IC50 7.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCN1CCN(CCCO)CC1 CHEMBL1090505 IC50 7.0 nM
Cc1nc(N)nc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL1762788 IC50 7.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@](C)(CCN(C)C)OC3)cc1 CHEMBL1774371 Ki 7.0 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4C[C@H]5CC[C@@H](C4)O5)n2)CS(=O)(=O)C3)cc1 CHEMBL2063760 Ki 7.0 nM
Cc1ncnc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL2165051 IC50 7.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3nc(C(C)(C)O)n(C)c3n2)cc1 CHEMBL2418354 Ki 7.0 nM
CCc1ncnc(N2CCC(C(C)(C)O)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670150 IC50 7.0 nM
CCc1ncnc(N2CCC(O)(c3ccccc3)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670155 IC50 7.0 nM
CCc1ncnc(N2CCN(CC(C)(C)O)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670218 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCS(=O)(=O)C4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640992 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCN(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3641000 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CC(=O)N(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643093 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCCCC4C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643095 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(c4ccccn4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643100 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(c4ccncc4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643101 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(O)(C(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643129 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)NC3CCN(C4CCN(C)CC4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643183 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CC(O)CO3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643193 IC50 7.0 nM
CCc1ncnc(-c2ccc(C(=O)N(C)OC)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643194 IC50 7.0 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc(-c3ccc4cc[nH]c4c3)[nH]c2n1 CHEMBL3667429 IC50 7.0 nM
CNc1ccc(C#Cc2c(-c3ccc(S(C)(=O)=O)cc3)ccnc2C)cn1 CHEMBL3701055 IC50 7.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701056 IC50 7.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCOCC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3701067 IC50 7.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C)CC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3701068 IC50 7.0 nM
CCc1nccc(-c2ccc(C(=O)NCCOC)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701126 IC50 7.0 nM
N#CCN1CCC(n2c(=O)cnc3cnc4ccc(-c5ccc(N)nc5)cc4c32)CC1 CHEMBL4079746 IC50 7.0 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCCOCCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5418348 IC50 7.02 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)CN(C)C4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648879 IC50 7.04 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CCN(C(=O)OC(C)(C)C)CC4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648867 IC50 7.08 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(CNCC4CC4)c3)nc2n1 CHEMBL3688999 IC50 7.1 nM
Cc1cccc2c(-c3ncc4c(n3)N3CCOC[C@@]3(C)C(=O)N4C3(CCCO)CC3)c[nH]c12 CHEMBL5433283 IC50 7.1 nM
COCCn1c(=O)n(C)c2cnc3ccc(-c4ccc(OC)nc4)nc3c21 CHEMBL3681185 Ki 7.13 nM
Cn1cc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL3681105 Ki 7.18 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nc(C3=CCOCC3)c3sccc3n2)cc1 CHEMBL589622 IC50 7.2 nM
Cn1c(=O)n(C2CCN(C(=O)C(C)(C)O)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681086 Ki 7.21 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C4CCS(=O)(=O)C4)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643245 IC50 7.24 nM
NC(=O)[C@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3cc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5083425 IC50 7.3 nM
O=C1OCC(c2ccccn2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653582 IC50 7.4 nM
CO[C@@H](C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653634 IC50 7.4 nM
C[C@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)F)nc(N2CCOCC2)n1 CHEMBL4453693 Ki 7.4 nM
NC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3cc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5085515 IC50 7.4 nM
Cn1cc(/C=C2\Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(N3CC4CCC3CO4)ccnc21 CHEMBL1090709 IC50 7.5 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)[C@H]2CC[C@@H](C3)N2C(C)=O)cc1 CHEMBL2334759 Ki 7.5 nM
Cc1nc(N)nc2c1cc(-c1cn[nH]c1)c(=O)n2[C@H]1CC[C@@H](OCO)CC1 CHEMBL2376092 Ki 7.5 nM
CC(C)[C@H]1CN(CCN2CCOCC2)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653547 IC50 7.5 nM
CC(C)C[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653580 IC50 7.5 nM
COc1cccc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)cc4)c3n2)n1 CHEMBL3653638 IC50 7.5 nM
CC(=O)Nc1cc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)ccn1 CHEMBL3688932 IC50 7.5 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(C(C)(C)C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643221 IC50 7.52 nM
Cn1cc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681137 Ki 7.55 nM
CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(CC(F)F)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645889 IC50 7.56 nM
CC(C)[C@H]1CN(C[C@H](O)CO)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653561 IC50 7.6 nM
NC(=O)C1CCCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3cc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5086413 IC50 7.6 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N(C)CCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808979 IC50 7.7 nM
CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(Cl)c(S(=O)(=O)NC)c4)n3)ccn2)cc1 CHEMBL2158864 IC50 7.7 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681083 Ki 7.74 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCCCC4C3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645779 IC50 7.8 nM
O=C1OC[C@H](Cc2ccccc2)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)c(F)c3)c2n1 CHEMBL3653591 IC50 7.8 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnn(C)c5)nc4c32)CC1 CHEMBL3681139 Ki 7.81 nM
Cc1nc(N)nc2c1cc(-c1cnc3ccccc3c1)c(=O)n2[C@H]1CC[C@H](OCO)CC1 CHEMBL2375965 Ki 7.82 nM
CCc1ncnc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643155 IC50 7.85 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)[C@@](C)(CCOC)OC3)cc1 CHEMBL1774374 Ki 7.9 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1 CHEMBL1234354 IC50 7.9 nM
CCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681068 Ki 7.9 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4166144 IC50 7.9 nM
Nc1nc2cc(-c3nn(CCCC(=O)NCCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5427223 IC50 7.9 nM
CNC(=O)Nc1ccc(-c2ncc3c(n2)N2CCOC[C@@]2(C)C(=O)N3CC2CC2)cc1 CHEMBL4466519 pIC50 7.943 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)CNC4)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645922 IC50 7.99 nM
CN(C)CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681087 Ki 7.99 nM
CN(C)CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)nc21 CHEMBL1091158 IC50 8.0 nM
Cc1nc(NCC#N)nc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL1762782 IC50 8.0 nM
O=C1CN(CCC2CCOCC2)c2nc(-c3ccc(-c4nc[nH]n4)cc3)cnc2N1 CHEMBL2348864 IC50 8.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(cnn3C)n2)cc1 CHEMBL2418348 IC50 8.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3ncn(CC)c3n2)cc1 CHEMBL2418340 Ki 8.0 nM
Cc1nc(-c2nc[nH]n2)ccc1-c1cnc2c(n1)N([C@H]1CC[C@@H](O)CC1)C(=O)CN2 CHEMBL3586566 IC50 8.0 nM
CCc1ncnc(N2CCC3(CCN(C)C3=O)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670214 IC50 8.0 nM
CCc1ncnc(-c2cc(C)nc(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640928 IC50 8.0 nM
Cc1ncnc(-c2ccc(S(C)(=O)=O)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3640932 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)NC)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3640980 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCCCC4C3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640993 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCOCC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640995 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640996 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCN(C)C)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643070 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(/C(=N/C)NC#N)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643122 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(O)(c4ccccc4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643131 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)C(C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643133 IC50 8.0 nM
CCCCN1CCN(C(=O)c2ccc(-c3ncnc(C)c3C#Cc3ccc(N)nc3)cc2)CC1 CHEMBL3643165 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)NC3CC(N4CCC(N5CCCC5)CC4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643181 IC50 8.0 nM
Cc1ncnc(-c2ccc(C(=O)N3CC(O)CO3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643201 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC(N4CCOCC4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643207 IC50 8.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](N(C)C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643209 IC50 8.0 nM
CC(C)[C@H]1CN(CCN2CCNC(=O)C2)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653549 IC50 8.0 nM
c1cc(-c2nc3c(N4CCOCC4)nc(N4CCOCC4)nc3[nH]2)c2cc[nH]c2c1 CHEMBL3667440 IC50 8.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)cc2)c1C#Cc1ccc(N)nc1 CHEMBL3701065 IC50 8.0 nM
COc1cnc(-c2ccc(NC(=O)Nc3ccc(N4CCSCC4)cc3)cc2)nc1N1CCOCC1 CHEMBL3928366 IC50 8.0 nM
C[C@@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)F)nc(N2CCOCC2)n1 CHEMBL4287799 Ki 8.0 nM
CC(C)n1nc2ncnc(N)c2c1C1C=c2cc(O)ccc2=N1 CHEMBL5285509 IC50 8.0 nM
COCCN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681132 Ki 8.09 nM
COc1cnc(-c2ccc(NC(=O)Nc3ccc(N4CCOCC4=O)cc3)cc2)nc1N1CCOCC1 CHEMBL3948281 IC50 8.1 nM
CCN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681067 Ki 8.11 nM
COC1CCN(C(=O)C2CCN(c3ccnc4c3c(/C=C3\Oc5ccc(NC(=O)Nc6cccnc6)cc5C3=O)cn4C)CC2)C1 CHEMBL1091702 IC50 8.2 nM
Cn1cc(/C=C2\Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(N3CCC(C(=O)N4CCCC4)CC3)ccnc21 CHEMBL1091699 IC50 8.2 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)NCCN4CCCCC4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808978 IC50 8.2 nM
CC(C)[C@H]1CNC(=O)N1c1ccn2ncc(-c3ccc(-c4ncc[nH]4)cc3)c2n1 CHEMBL3653527 IC50 8.2 nM
C[C@@H]1COCCN1c1nc(-c2nnc(N)s2)nc2c1C[C@@H]1COCCN21 CHEMBL4752187 Ki 8.2 nM
O=[N+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL17331 Potency 8.3 nM
CN(C)c1ccc(/C=C2\C(=O)Nc3ccccc32)cc1 CHEMBL328710 Potency 8.3 nM
CC(C)[C@H]1CN(CCCO)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653541 IC50 8.3 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccc(C(N)=O)cc3)nc2n1 CHEMBL3688866 IC50 8.3 nM
CN(Cc1ccccn1)C(=O)C1CCN(c2ccnc3c2c(/C=C2\Oc4ccc(NC(=O)Nc5cccnc5)cc4C2=O)cn3C)CC1 CHEMBL1091706 IC50 8.4 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCNCC2)c(=O)n4C)cn1 CHEMBL3681119 Ki 8.41 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n(Cc5ccccc5)c4c3n2)cn1 CHEMBL3681077 Ki 8.44 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(CCN)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645950 IC50 8.45 nM
O=S(=O)(c1ccc(O)cc1)N1CCN(c2nc(NCCN3CCOCC3)nc(N3CCOCC3)n2)CC1 CHEMBL4789747 IC50 8.45 nM
COc1ncc(-c2cc3c(C)nc(N)cc3n(C3CCCC3)c2=O)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL3112711 IC50 8.49 nM
CN1Cc2cnc3ccc(-c4cnc(N)nc4)nc3c2N(c2cccc(C(F)(F)F)c2)C1=O CHEMBL3916654 IC50 8.5 nM
COc1cccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)c1 CHEMBL3681190 Ki 8.51 nM
COc1ncc(-c2cc3c(C)nc(N)cc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3112730 IC50 8.55 nM
C#CCN1CCN(C(=O)c2c(F)cc(-c3ncnc(CC)c3C#Cc3ccc(N)nc3)cc2F)CC1 CHEMBL3645846 IC50 8.6 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCC(=O)O)CC3)c2=O)cn1 CHEMBL2376096 Ki 8.63 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(-c4cc(C(=O)O)cc([N+](=O)[O-])c4)nc3n2)cc1CO CHEMBL3693567 IC50 8.7 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)OCCCO4)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643229 IC50 8.74 nM
CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCSCC5)nc(N5C6CCC5COC6)n4)cc3)cc2)CC1 CHEMBL1091347 IC50 8.8 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCC(N)=O)CC3)c2=O)cn1 CHEMBL2375956 Ki 8.8 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3cccnc3n2)cc1)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 CHEMBL4095781 IC50 8.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](N(C)C)C3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3645853 IC50 8.83 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C)CC3)c(C(F)(F)F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645901 IC50 8.85 nM
CCc1ncnc(-c2ccc(C(=O)N3CCCO3)c(OC)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643241 IC50 8.86 nM
CN1Cc2cnc3ccc(-c4ccc(N)nc4)nc3c2N(c2cccc(C(F)(F)F)c2)C1=O CHEMBL3982245 IC50 8.86 nM
CCc1ncnc(-c2ccc(C(=O)N3CCOC(C)(C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643125 IC50 8.89 nM
CCc1ncnc(-c2ccc(C(=O)N3CC[C@H](O)C3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645801 IC50 8.91 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)CN(C(=O)OC(C)(C)C)CCO4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645987 IC50 8.92 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CN(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681114 Ki 8.96 nM
c1cncc(CN2CCC(n3ncc4c(N5CCOCC5)nc(-c5ccc6[nH]ccc6c5)nc43)CC2)c1 CHEMBL583194 IC50 9.0 nM
Cn1cc(/C=C2\Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(N3CCC(C(=O)NCc4cccnc4)CC3)ccnc21 CHEMBL1091703 IC50 9.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCN1CCOCC1 CHEMBL1089823 IC50 9.0 nM
Cc1nc(N)nc2c1nc(-c1cn[nH]c1)c(=O)n2C(C)C CHEMBL1234917 Ki 9.0 nM
O=c1[nH]c2ncc(-c3ccc(-c4nc[nH]n4)cc3)nc2n1CC1CCCCC1 CHEMBL1945952 IC50 9.0 nM
O=c1[nH]c2ncc(-c3ccc(-c4ncc[nH]4)cc3)nc2n1CC1CCCCC1 CHEMBL1945954 IC50 9.0 nM
CC(=O)Nc1cc(-c2c(Nc3cc[nH]n3)nc3ccccn23)nc(C)n1 CHEMBL2172475 IC50 9.0 nM
COC1(c2sc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3c2C)COC1 CHEMBL2178608 Ki(app) 9.0 nM
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3nc(C(C)(C)O)n(CCO)c3n2)cc1 CHEMBL2418353 Ki 9.0 nM
CCc1ncnc(N2CCC(CC(C)(C)O)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670153 IC50 9.0 nM
Cc1ncnc(N2CCC(CCO)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670169 IC50 9.0 nM
CCc1ncnc(N2CCC(C(F)(F)F)CC2)c1C#Cc1ccc(N)nc1 CHEMBL3670180 IC50 9.0 nM
CCc1ncnc(N2CCC(OC)CC2)c1C#Cc1ccc(NC)nc1 CHEMBL3670223 IC50 9.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(S(=O)(=O)CC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640994 IC50 9.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1C CHEMBL3640998 IC50 9.0 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(OC)CC3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643114 IC50 9.0 nM
Cc1ncnc(-c2ccc(C(=O)N3CC(O)CO3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643205 IC50 9.0 nM
C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc(-c3cccc4[nH]ccc34)[nH]c2n1 CHEMBL3639662 IC50 9.0 nM
CCc1cc(-c2ccnc(CC)c2C#Cc2ccc(N)nc2)ccn1 CHEMBL3701072 IC50 9.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(CC)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1 CHEMBL3701084 IC50 9.0 nM
Cc1nccc(-c2ccc(C(=O)N(C)C)nc2)c1C#Cc1ccc(N)nc1 CHEMBL3701108 IC50 9.0 nM
CCc1nccc(-c2ccc(C(=O)N3CC(C)N(CCOC)C(C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701143 IC50 9.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(CC)C(C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701145 IC50 9.0 nM
CCc1nccc(-c2ccc(C(=O)N3CCN(C)C(C)(C)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701146 IC50 9.0 nM
CCc1nccc(-c2ccc(C(=O)N3C[C@@H]4CC3CN4C)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701148 IC50 9.0 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](OCCO)CC2)c(=O)n4C)cn1 CHEMBL3639799 Ki 9.02 nM
COc1ncc(-c2ccc3ncc4[nH]c(=O)n(-c5ccc(C(C)(C)C#N)cc5)c4c3n2)cc1F CHEMBL3681058 Ki 9.03 nM
Cc1nc(N)nc2c1cc(-c1cnc3ccccc3c1)c(=O)n2[C@H]1CC[C@H](OCC(N)=O)CC1 CHEMBL2375953 Ki 9.1 nM
CNCc1cccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)c1 CHEMBL3688997 IC50 9.1 nM
C[C@H]1COCCN1c1nc(-c2ccc(N)nc2)nc2c1C[C@@H]1COCCN21 CHEMBL4458426 Ki 9.1 nM
C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3cccc(C(=O)O)c3)nc2n1 CHEMBL3688873 IC50 9.2 nM
C[C@H]1COCCN1c1ccnc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCC[C@H]4C(N)=O)cc3)cc2)n1 CHEMBL5073129 IC50 9.2 nM
CCNc1ccc(C#Cc2c(CC)ncnc2-c2ccc(C(=O)N3CC4(CN(C(=O)OC(C)(C)C)C4)C3)c(F)c2)cn1 CHEMBL3645938 IC50 9.26 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1)Nc1ccc(F)cc1F CHEMBL597815 IC50 9.3 nM
CN(Cc1ccncc1)C(=O)C1CCN(c2ccnc3c2c(/C=C2\Oc4ccc(NC(=O)Nc5cccnc5)cc4C2=O)cn3C)CC1 CHEMBL1091705 IC50 9.3 nM
Cc1ccc([C@H]2COC(=O)N2c2ccn3ncc(-c4ccc(-c5nc[nH]n5)c(F)c4)c3n2)nc1 CHEMBL3653628 IC50 9.3 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN4CCC[C@H]4C3)c(OC(F)(F)F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645895 IC50 9.33 nM
CC(C)[C@H]1CN(C)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653540 IC50 9.4 nM
COc1ccc(-c2ccc3c(N4CCOC[C@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO CHEMBL3693561 IC50 9.4 nM
CNC(=O)Nc1ccc2c(c1)C(=O)/C(=C/c1cn(C)c3nccc(N4CC5CCC(C4)O5)c13)O2 CHEMBL1093069 IC50 9.5 nM
O=C1N[C@@H]2CCCC[C@@H]2N1c1ccn2ncc(-c3ccc(-c4ncc[nH]4)cc3)c2n1 CHEMBL3653531 IC50 9.5 nM
COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N(CCO)CCO)nc3n2)cc1CO CHEMBL3693532 IC50 9.5 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCCO[N+](=O)[O-])c4ncnc(N)c34)ccc2o1 CHEMBL5424956 IC50 9.5 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCCCCCOc4no[n+]([O-])c4S(=O)(=O)c4ccccc4)c4ncnc(N)c34)ccc2o1 CHEMBL5415471 IC50 9.52 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(c4ccncc4)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645809 IC50 9.55 nM
Cn1c(=O)n(C2CCN(CC(F)(F)F)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681084 Ki 9.56 nM
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)N[C@H](CCc2ccccc2)C(=O)NCC(=O)N(C)CC(=O)O[C@H]1C CHEMBL371029 IC50 9.6 nM
Oc1cccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(Cc5cccnc5)CC4)c3n2)c1 CHEMBL550286 IC50 9.6 nM
Nc1ccc(-c2nc(N3CCOCC3)c3cnn(-c4ccccc4)c3n2)cn1 CHEMBL1095618 IC50 9.6 nM
CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(C(C)C)C3)cc1 CHEMBL2331678 Ki 9.6 nM
CN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681133 Ki 9.62 nM
C[C@H](CO)n1c(=O)n(C)c2cnc3ccc(-c4cnc5ccccc5c4)nc3c21 CHEMBL3681158 Ki 9.63 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(c4ccncc4)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3643158 IC50 9.65 nM
CCc1ncnc(-c2ccc(C(=O)N3CCN(C(C)=O)CC3)c(C)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645786 IC50 9.66 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CN(C(=O)OC(C)(C)C)C4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645989 IC50 9.67 nM
CC(C)OC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681075 Ki 9.72 nM
CCc1ncnc(-c2ccc(C(=O)N3CCC4(CC3)CC(NC(=O)OC(C)(C)C)C4)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645985 IC50 9.74 nM
CCc1ncnc(-c2cc(Cl)c(C(=O)N3CC4(CN(C)C4)C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3648873 IC50 9.74 nM
CC(C)[C@H]1CN(CCN2CC[C@@H](F)C2)C(=O)N1c1ccn2ncc(-c3ccc(-c4nc[nH]n4)cc3)c2n1 CHEMBL3653543 IC50 9.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CC4(CN(C)C4)C3)c(F)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645953 IC50 9.81 nM
Nc1nc2cc(-c3nn(CCCC(=O)OCCCO[N+](=O)[O-])c4ncnc(N)c34)ccc2o1 CHEMBL5420541 IC50 9.82 nM
CCOC(=O)N1CCN(CC#Cc2ccnc3ccc(-c4cnc(OC)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)CC1 CHEMBL3765587 IC50 9.9 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3cccnc3n2)cc1)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1 CHEMBL4069475 IC50 9.9 nM
COc1ncc(-c2cc(O[C@@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4176771 IC50 9.9 nM