O=C(/C=C/c1cccnc1)NCCCCC1CCN(C(=O)c2ccccc2)CC1 CHEMBL566757 IC50 0.0301 nM
O=C(/C=C/c1cccnc1)NCCCCCc1cn(-c2ccccc2-c2ccccc2)nn1 CHEMBL3753643 IC50 0.0509 nM
O=C(/C=C/c1cccnc1)NCCCCC1CCN(C(=O)c2cccc(N(CCCl)CCCl)c2)CC1 CHEMBL5429026 IC50 0.15 nM
CC(C)N(CCc1c[nH]c2ccccc12)Cc1ccc(NCCCCCNC(=O)/C=C/c2cccnc2)cc1 CHEMBL4544378 IC50 0.155 nM
O=C(/C=C/c1cccnc1)NCCCCC1CCN(C(=O)c2ccccc2N(CCCl)CCCl)CC1 CHEMBL5437893 IC50 0.16 nM
CC(C)CCN(C(=O)COc1ccccc1)c1ncc(C(=O)NCCCn2ccnc2)s1 CHEMBL3260316 IC50 0.174 nM
N#C/N=C(\NCCCCCCC(=O)N(OCCN1CCOCC1)C1CCCCC1)Nc1ccncc1 CHEMBL3094250 IC50 0.2 nM
CC(C)(C)OC(=O)NCCOCCOCC(=O)NCc1cccc(C(=O)N2CCC(CCCCNC(=O)/C=C/c3cccnc3)CC2)c1 CHEMBL4440516 Ki 0.2 nM
C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(C)CC3)nc2cc1Br)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL2417796 IC50 0.23 nM
C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(CCCN)CC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801863 IC50 0.3 nM
N#C/N=C(\NCCCCCCS(=O)(=O)N(OCCN1CCOCC1)C1CCCCC1)Nc1ccncc1 CHEMBL3094255 IC50 0.3 nM
C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(C)CC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL123756 IC50 0.31 nM
CC1(CC(=O)N2CCC3(CC2)CC3CNC(=O)N2Cc3ccncc3C2)CCOCC1 CHEMBL3968268 IC50 0.4 nM
COCC(=O)N(CCC(C)C)c1ncc(C(=O)NCCCn2ccnc2)s1 CHEMBL3260317 IC50 0.412 nM
CC(C)=CCN(Cc1cc2c(=O)n(C)nnc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801864 IC50 0.45 nM
O=C(NCCCn1ccnc1)c1cnc(N(Cc2ccc(F)cc2)C(=O)CC2CCCCC2)s1 CHEMBL3260314 IC50 0.461 nM
C#CCN(Cc1cc2c(=O)n(C)c(C)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801934 IC50 0.55 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)Nc1ccncc1 CHEMBL3098518 IC50 0.6 nM
CC1(OC(=O)N2CCC3(CC2)C[C@@H]3CNC(=O)N2Cc3ccncc3C2)COC1 CHEMBL3916438 IC50 0.6 nM
O=C(NCCCn1ccnc1)c1cnc(N(Cc2ccc(F)cc2)C(=O)CN2CC=CCC2)s1 CHEMBL3260315 IC50 0.632 nM
C#CCN(Cc1cc2c(=O)n(C)c(CO)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801862 IC50 0.79 nM
O=C(CC1CC1)N[C@H]1CC[C@@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3900725 IC50 0.86 nM
CN1CCN(c2ccc(S(=O)(=O)c3ccc(CNC(=O)c4cc5ccncc5o4)nc3)cn2)CC1 CHEMBL3914799 IC50 0.916 nM
N#Cc1ccc2c(c1)CN(C(=O)NCCCCC1CCN(C(=O)c3ccccc3)CC1)C2 CHEMBL3919342 IC50 0.946 nM
CC(C)C(=O)N[C@H]1CC[C@@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3900838 IC50 0.973 nM
COc1cc(OC)cc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)c1 CHEMBL3951542 IC50 0.99 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cc1)c1cnc2nccn2c1 CHEMBL2420634 IC50 1.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cnc2nccn2c1 CHEMBL2420633 IC50 1.0 nM
N#CN=C(NCCCCCCOc1ccc(Cl)cc1)Nc1ccncc1 CHEMBL17289 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC2(CC1)C[C@@H]2CNC(=O)N1Cc2ccncc2C1 CHEMBL3948584 IC50 1.0 nM
[2H]C1([2H])c2ccncc2C([2H])([2H])N1C(=O)NCC1CC12CCN(C(=O)OC1(C)COC1)CC2 CHEMBL3986197 IC50 1.0 nM
O=C(Nc1ccc(C2CCN(C(=O)c3ccccc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3943749 Ki 1.0 nM
CC(C)(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3921331 IC50 1.03 nM
N#C/N=C(\NCCCCCCC(=O)NOC1CCCCC1)Nc1ccncc1 CHEMBL3094249 IC50 1.1 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)c1ccc2nccn2c1 CHEMBL2420629 EC50 1.1 nM
O=C(CCCCCc1cn(-c2ccccc2-c2ccccc2)nn1)NCc1cccnc1 CHEMBL3753517 IC50 1.1 nM
CC(C)Oc1cccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3943896 IC50 1.1 nM
NCc1cccc(C(=O)N2CCC(CCCCNC(=O)/C=C/c3cccnc3)CC2)c1 CHEMBL4471163 Ki 1.1 nM
O=C(/C=C/c1cccnc1)NCCCCC1CCN(C(=O)c2ccc(N(CCCl)CCCl)cc2)CC1 CHEMBL5439032 IC50 1.1 nM
CC(C)=CCN(Cc1ccc2ncn(C)c(=O)c2c1)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801566 IC50 1.2 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)c2ccccc2OC(F)(F)F)cc1 CHEMBL2417788 IC50 1.2 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cnc2[nH]ncc2c1 CHEMBL3260358 EC50 1.2 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C3=CCN(C(=O)C4CCOC4)CC3)cc1)C2 CHEMBL3953619 IC50 1.22 nM
O=C(NCc1cccnc1)c1ccc(N(Cc2ccccc2Cl)CC2CC2)cc1 CHEMBL1801561 IC50 1.3 nM
CC1(CCCCCC(=O)NCCOCCOCC(=O)NCc2cccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)c2)C(/C=C/C=C/C=C2/N(CCCS(=O)(=O)O)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCS(=O)(=O)[O-])c2ccc(S(=O)(=O)O)cc21 CHEMBL4446883 Ki 1.3 nM
O=C(/C=C/c1cccnc1)OCCCCC1CCN(C(=O)c2ccccc2N(CCCl)CCCl)CC1 CHEMBL5413966 IC50 1.3 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C3=CCN(C(=O)C4CCOCC4)CC3)cc1)C2 CHEMBL3890571 IC50 1.34 nM
CCC(C)(O)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3914619 IC50 1.35 nM
CC(C)C(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3922186 IC50 1.37 nM
CC(C)=CCN(Cc1ccc2nc(C)n(C)c(=O)c2c1)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801552 IC50 1.4 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cncc(N3CCCC3)c2)cc1 CHEMBL3969390 IC50 1.4 nM
CC(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccc(C#N)cc4C3)cc2)CC1 CHEMBL3985621 IC50 1.44 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5401142 IC50 1.47 nM
Cc1cc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)nn1C CHEMBL3924470 IC50 1.49 nM
C/C=C/CN(Cc1ccccc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801563 IC50 1.5 nM
Cc1nc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)co1 CHEMBL3938898 IC50 1.5 nM
CN1CCN(C(C)(C)C(=O)N2CCC(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)CC1 CHEMBL4060799 Ki 1.5 nM
CC(C)(O)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccc(C#N)cc4C3)cc2)CC1 CHEMBL3910840 IC50 1.51 nM
O=C(CC1CC1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3972815 IC50 1.52 nM
CC(C)(O)CC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3968930 IC50 1.53 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5408614 IC50 1.53 nM
CCC(C)CCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3953470 IC50 1.55 nM
O=C(NCCCCC1CCN(C(=O)c2ccccc2)CC1)N1Cc2ccncc2C1 CHEMBL3916971 IC50 1.57 nM
O=C(Nc1ccc(OC2CCN(C(=O)c3ccccc3)C2)cc1)N1Cc2ccncc2C1 CHEMBL3910326 IC50 1.57 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3907391 IC50 1.59 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(-c4ccncc4)cc3C2)cc1 CHEMBL3954704 IC50 1.59 nM
Cn1cccc1C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3926772 IC50 1.59 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5398077 IC50 1.59 nM
CC(C)(C)OC(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3893879 IC50 1.6 nM
CC(C)(C)CC(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3963163 IC50 1.6 nM
Cc1nc(C)c(C(=O)N2CCC3(CC2)CC3CNC(=O)N2Cc3ccncc3C2)o1 CHEMBL3958233 IC50 1.6 nM
COCC(C)(C)OC(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3913883 IC50 1.6 nM
O=C(NCCCCC1CCN(C(=O)c2ccccc2)CC1)N1Cc2ccccc2C1 CHEMBL3960317 Ki 1.6 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(Br)cc3C2)cc1 CHEMBL3903966 IC50 1.66 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3933632 IC50 1.68 nM
CC1(C)CC1C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3982191 IC50 1.68 nM
COCCNC(=O)c1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3933582 IC50 1.69 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cc1)Nc1ccncc1 CHEMBL3098517 IC50 1.7 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cn1)c1cc2ccncc2s1 CHEMBL3901958 IC50 1.7 nM
O=C(Nc1ccc(C2CCN(C(=O)[C@@H]3CCCO3)CC2)cc1)N1Cc2ccc(Cl)cc2C1 CHEMBL4083505 Ki 1.7 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C3=CCN(C(=O)CN4CCOCC4)CC3)cc1)C2 CHEMBL3972869 IC50 1.72 nM
O=C(N[C@H]1CC[C@@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1)[C@H]1CCCO1 CHEMBL3916303 IC50 1.74 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCC3CCCO3)cc1)C2 CHEMBL3957341 IC50 1.76 nM
COc1ccc(C)cc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3901233 IC50 1.8 nM
CCC(C)(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3898729 IC50 1.83 nM
CC(C)=CCN(Cc1ccccc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801562 IC50 1.9 nM
COc1cccc(S(=O)(=O)c2ccc(CN/C(=N\C#N)Nc3ccncc3)cc2)c1 CHEMBL3098610 IC50 1.9 nM
Cn1ncc2cc(S(=O)(=O)c3ccc(NC(=O)/C=C/c4cccnc4)cc3)ccc21 CHEMBL3961349 IC50 1.9 nM
CC(=O)c1cccc(-c2ccc3c(c2)c(CCCO)cc(=O)n3CCCCNC(=O)N2Cc3ccccc3C2)c1 CHEMBL3913785 IC50 1.9 nM
O=C(CC1CCC1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3970843 IC50 1.9 nM
O=C(Nc1ccc(C2CN(C(=O)c3ccccc3)C2)cc1)N1Cc2ccc(F)cc2C1 CHEMBL4096471 Ki 1.9 nM
NCCOCCOCC(=O)NCc1cccc(C(=O)N2CCC(CCCCNC(=O)/C=C/c3cccnc3)CC2)c1 CHEMBL4572898 Ki 1.9 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3cnccn3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3914368 IC50 1.91 nM
COc1cc(CNC(=O)c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)cc(OC)c1 CHEMBL3950440 IC50 1.92 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)c1cnc2nccn2c1 CHEMBL2420632 IC50 2.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)c1cnc2nccn2c1 CHEMBL2420638 IC50 2.0 nM
O=C(NCc1ccc(S(=O)(=O)C2CCCCC2)cc1)N1Cc2ccncc2C1 CHEMBL2417572 IC50 2.0 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2cccnc2)cc1)Nc1ccncc1 CHEMBL3098516 IC50 2.0 nM
CC(C)(O)Cn1cc(S(=O)(=O)c2ccc(NC(=O)[C@@H]3C[C@H]3c3cccnc3)cc2)cn1 CHEMBL3127508 IC50 2.0 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2ccc(F)cc2)cc1 CHEMBL3914562 IC50 2.0 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccccc3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3942792 IC50 2.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cn1)c1cc2ccncc2o1 CHEMBL3914395 IC50 2.0 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(-c4cccnc4)cc3C2)cc1 CHEMBL3980305 IC50 2.01 nM
O=C(NCCCCC1CCN(C(=O)c2ccccc2Cl)CC1)N1Cc2ccncc2C1 CHEMBL3893420 IC50 2.01 nM
O=C(Nc1ccc(C2=CCN(C(=O)[C@H]3CCOC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3947751 IC50 2.01 nM
CC1(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)CC1 CHEMBL3933718 IC50 2.02 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCC3CCCOC3)cc1)C2 CHEMBL3921826 IC50 2.03 nM
Cc1cc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)n(C)n1 CHEMBL3944741 IC50 2.03 nM
O=C(NCc1ccc(Cl)cc1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3922721 IC50 2.06 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCC3CCCC3)cc1)C2 CHEMBL3983465 IC50 2.07 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCc3ccoc3)cc1)C2 CHEMBL3942126 IC50 2.07 nM
CC(C)(O)C(=O)N1CCC(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3943777 IC50 2.07 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)cc2)cn1)c1cnc2nccn2c1 CHEMBL3954293 IC50 2.1 nM
O=C(CC1CCCC1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3973962 IC50 2.11 nM
CCS(=O)(=O)c1cccc(S(=O)(=O)c2ccc(CNC(=O)N3Cc4ccncc4C3)nc2)c1 CHEMBL3942797 IC50 2.12 nM
CCCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3933820 IC50 2.13 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5432491 IC50 2.14 nM
CCC(CC)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3967478 IC50 2.19 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2ccccc2)cc1)Nc1cccnc1 CHEMBL3098512 IC50 2.2 nM
CC1(OC(=O)N2CCC3(CC2)CC3CNC(=O)N2Cc3ccncc3C2)COC1 CHEMBL3983716 IC50 2.2 nM
CC(C)CCNS(=O)(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3940862 IC50 2.2 nM
CN1CCN(c2ccc(S(=O)(=O)c3ccc(CNC(=O)c4cnc5nccn5c4)nc3)cn2)CC1 CHEMBL3907245 IC50 2.2 nM
CN(C)c1ncc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4s3)nc2)s1 CHEMBL3901715 IC50 2.2 nM
CC(=O)c1cccc(-c2ccc3c(ccc(=O)n3CCCCNC(=O)N3Cc4ccccc4C3)c2)c1 CHEMBL3962347 IC50 2.21 nM
O=C(Nc1ccc(C2CCN(C(=O)[C@@H]3CCCO3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3986524 IC50 2.21 nM
CC(C)CC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3972980 IC50 2.22 nM
N#Cc1ccc2c(c1)CN(C(=O)NCCCCCCNC(=O)c1cccnc1)C2 CHEMBL3914047 IC50 2.23 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3(O)CC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3922772 IC50 2.28 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc3[nH]ccc23)cc1 CHEMBL3956022 IC50 2.3 nM
CN1CCN(c2ccc(S(=O)(=O)c3ccc(CNC(=O)c4cnc5nccn5c4)nc3)cc2)CC1 CHEMBL3922747 IC50 2.3 nM
CC(=O)c1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3897103 IC50 2.31 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CC3(F)F)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3896490 IC50 2.34 nM
O=C(Nc1ccc(NC(=O)N2Cc3ccncc3C2)cc1)C1CC2CCC1C2 CHEMBL3962339 IC50 2.37 nM
N#C/N=C(\NCCCCCCS(=O)(=O)N(CCCN1CCOCC1)C1CCCCC1)Nc1ccncc1 CHEMBL3094258 IC50 2.4 nM
N#C/N=C(\NCCCCCCS(=O)(=O)NOCC1CCCCC1)Nc1ccncc1 CHEMBL3094254 IC50 2.4 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)Nc1ccncc1 CHEMBL3098608 IC50 2.4 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)N2CC3CCC(C2)O3)cc1)Nc1ccncc1 CHEMBL3098511 IC50 2.4 nM
CC(C)/C=C/C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3906160 IC50 2.44 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cncc3ccccc23)cc1 CHEMBL3953734 IC50 2.45 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(-c4cc[nH]n4)cc3C2)cc1 CHEMBL3951369 IC50 2.47 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2ccccc2)cc1)Nc1ccncc1 CHEMBL3098510 IC50 2.5 nM
COc1ccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cc1OC CHEMBL3981508 IC50 2.5 nM
CC(C)(O)CC(=O)N1CCC(c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)CC1 CHEMBL4089003 Ki 2.5 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NC[C@@H]3CCCO3)cc1)C2 CHEMBL3928844 IC50 2.51 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCCCc3ccccc3)cc1)C2 CHEMBL3958422 IC50 2.52 nM
COc1ccccc1C(=O)NCCCCCCNC(=O)N1Cc2ccccc2C1 CHEMBL3902477 IC50 2.53 nM
O=C(Nc1ccc(C2=CCN(C(=O)[C@@H]3CCCO3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3925424 IC50 2.59 nM
CC(C)=CCN(Cc1cc2c(=O)n(C)cnc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801567 IC50 2.6 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2cccc(Cl)c2)cc1)Nc1ccncc1 CHEMBL2417789 IC50 2.6 nM
COc1ccc(C(C)C)cc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3931923 IC50 2.6 nM
Cn1ncc2ccc(S(=O)(=O)c3ccc(NC(=O)/C=C/c4cccnc4)cc3)cc21 CHEMBL3965551 IC50 2.6 nM
CCCn1cc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cn1 CHEMBL3968921 IC50 2.6 nM
N#Cc1ccc2c(c1)CN(C(=O)NCCCCc1ccccc1)C2 CHEMBL3905794 IC50 2.6 nM
O=C(N[C@H]1CC[C@@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1)[C@@H]1CCCO1 CHEMBL3904586 IC50 2.6 nM
CN(C)c1ccc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)cn1 CHEMBL3973696 IC50 2.6 nM
COCC1(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)CC1 CHEMBL3921130 IC50 2.64 nM
COc1ccc(C(=O)NCCCCCCNC(=O)N2Cc3ccccc3C2)c(OC)c1 CHEMBL3957315 IC50 2.65 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5404254 IC50 2.67 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(C(=O)NCCO)cc3C2)cc1 CHEMBL3967676 IC50 2.7 nM
O=C(Nc1ccc(CN2C(=O)c3ccccc3C2=O)cc1)N1CC(c2cccnc2)C1 CHEMBL4546918 IC50 2.7 nM
O=C(NCC1CCN(C(=O)C2CCOC2)C1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3951730 IC50 2.77 nM
NCc1ccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)cc1 CHEMBL3932952 IC50 2.78 nM
CCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3935701 IC50 2.8 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)cc2)cn1)c1cc2ccncc2s1 CHEMBL3924358 IC50 2.8 nM
COc1ccc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)cc1OC CHEMBL3973866 IC50 2.8 nM
CC(C)(O)CNC(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3966908 IC50 2.87 nM
C/C=C/CN(Cc1ccc2nc(C)n(C)c(=O)c2c1)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801855 IC50 2.9 nM
O=C(NCCCCn1c(=O)ccc2cc(Br)ccc21)N1Cc2ccccc2C1 CHEMBL3940366 IC50 2.95 nM
O=C(CCn1cccc1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3971687 IC50 2.95 nM
NC(=O)c1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3956607 IC50 2.97 nM
CN1CCN(CC(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)CC1 CHEMBL3921001 IC50 2.97 nM
CCCC(=O)Nc1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3902590 IC50 2.98 nM
CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3972460 IC50 2.99 nM
O=C(CCCCCCCn1cc(-c2cccnc2)nn1)Nc1ccccc1-c1ccccc1 CHEMBL568305 IC50 3.0 nM
O=C(NCc1ccc2nccn2c1)Nc1ccc(S(=O)(=O)c2ccccc2)cc1 CHEMBL2391585 IC50 3.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N2CCNC(C(F)(F)F)CC2)cc1 CHEMBL2393168 IC50 3.0 nM
Nc1ccc(CNC(=O)Nc2ccc(S(=O)(=O)c3ccccc3)cc2)cn1 CHEMBL2393183 IC50 3.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)c2ccccc2)cc1 CHEMBL2391572 IC50 3.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cc1)c1cc2ccncc2s1 CHEMBL2420628 IC50 3.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cc2ccncc2s1 CHEMBL2420627 IC50 3.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)c1cc2ccncc2s1 CHEMBL2420626 IC50 3.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cc1)c1cc2ccncc2o1 CHEMBL2420625 IC50 3.0 nM
O=C(NCc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1cnc2nccn2c1 CHEMBL2420637 IC50 3.0 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2ccccc2)cc1 CHEMBL2417790 IC50 3.0 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)N2CC3CCC(C2)O3)cc1 CHEMBL3902416 IC50 3.0 nM
O=C(/C=C/c1cccnc1)NCc1ccc(S(=O)(=O)c2ccccc2)cc1 CHEMBL3969206 IC50 3.0 nM
O=C(NCc1ccc(S(=O)(=O)C2CCN(CC(F)(F)F)CC2)cn1)c1cnc2nccn2c1 CHEMBL3927324 IC50 3.0 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccccc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3922276 Ki 3.0 nM
CC(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3911374 IC50 3.02 nM
O=C(NCC1CCC2(CCNCC2)O1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3940377 IC50 3.02 nM
O=C(NCCCCCCNC(=O)N1Cc2ccncc2C1)c1ccccc1 CHEMBL3986780 IC50 3.03 nM
CC(C)(O)C(=O)N1CCC(CCCCNC(=O)N2Cc3ccncc3C2)CC1 CHEMBL3913656 IC50 3.07 nM
CCCn1cc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4s3)nc2)cn1 CHEMBL3968358 IC50 3.1 nM
O=C(NCc1cccnc1)Nc1ccc(CN2C(=O)c3ccccc3C2=O)cc1 CHEMBL4206641 IC50 3.1 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NC[C@H]3CCCO3)cc1)C2 CHEMBL3973682 IC50 3.11 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5428751 IC50 3.12 nM
CC(C)S(=O)(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3894253 IC50 3.15 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3920134 IC50 3.18 nM
N#C/N=C(\NCCCCCCS(=O)(=O)N(CCF)OCC1CCCCC1)Nc1ccncc1 CHEMBL3094257 IC50 3.2 nM
COc1cc(F)cc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3903178 IC50 3.2 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccccc3F)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3944711 IC50 3.21 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCOC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3919961 IC50 3.22 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(Cl)cc3C2)cc1 CHEMBL3929527 IC50 3.22 nM
O=C(NCCCCN1C(=O)C2CC3COCC32c2ccc(Cl)cc21)N1Cc2ccncc2C1 CHEMBL3903507 IC50 3.23 nM
COC1CCC(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)CC1 CHEMBL3894167 IC50 3.23 nM
Cc1nn(C)cc1C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3917598 IC50 3.24 nM
O=C(NCCCCn1c(=O)c2c(c3cc(Cl)ccc31)C(CCO)C2)N1Cc2ccncc2C1 CHEMBL3940527 IC50 3.25 nM
COc1cccc(CNC(=O)c2ccc(N(F)C(=O)N3Cc4ccccc4C3)cc2)c1 CHEMBL3961415 IC50 3.26 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3=CCCC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3977854 IC50 3.26 nM
O=C(CC1CCCO1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3927332 IC50 3.28 nM
CCc1cccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3930617 IC50 3.3 nM
O=C(NCc1ccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)cc1)c1ccccc1 CHEMBL3964742 IC50 3.31 nM
CC(C)(O)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3901921 IC50 3.36 nM
Cn1cc(-c2ccc3c(c2)CN(C(=O)Nc2ccc(NC(=O)CC4CCCC4)cc2)C3)cn1 CHEMBL3909194 IC50 3.38 nM
Cc1ccccc1C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3956842 IC50 3.39 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCC3CCOCC3)cc1)C2 CHEMBL3918373 IC50 3.4 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cn1)c1cnc2nccn2c1 CHEMBL3935129 IC50 3.4 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cn1)N1Cc2ccncc2C1 CHEMBL3925078 IC50 3.4 nM
O=C(CC1CCOCC1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3896452 IC50 3.47 nM
O=C(NCC1CC12CCN(C(=O)c1ccccc1)CC2)N1Cc2ccncc2C1 CHEMBL3984355 IC50 3.5 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc3c2oc2ccccc23)cc1 CHEMBL3913937 IC50 3.5 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)cc2)cn1)c1cc2ccncc2o1 CHEMBL3923144 IC50 3.5 nM
N#C/N=C(\NCCCCCCS(=O)(=O)N(Cc1ccco1)C1CCCC1)Nc1ccncc1 CHEMBL5428441 IC50 3.5 nM
CC(C)CC(CO)NC(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3911470 IC50 3.53 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NC(CO)c3ccccn3)cc1)C2 CHEMBL3940933 IC50 3.58 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)N[C@H](CCO)c3ccccc3)cc1)C2 CHEMBL3972897 IC50 3.59 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCC3CCOC3)cc1)C2 CHEMBL3954943 IC50 3.59 nM
C#CCN(Cc1ccc2nc(C)n(C)c(=O)c2c1)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801937 IC50 3.6 nM
O=C1C(=O)C(Nc2ccncc2)C1NCCCCCCCS(=O)(=O)N(OCCN1CCOCC1)C1CCCCC1 CHEMBL3094229 IC50 3.6 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2cccc3cccnc23)cc1)Nc1ccncc1 CHEMBL3098611 IC50 3.6 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2ccccc2OC(F)(F)F)cc1 CHEMBL3915028 IC50 3.6 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc3cccnc23)cc1 CHEMBL3948110 IC50 3.6 nM
O=C(CN1CCOCC1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3965636 IC50 3.61 nM
CCC(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3893317 IC50 3.62 nM
CN1CCC(CNC(=O)c2ccc(NC(=O)N3Cc4ccc(C#N)cc4C3)cc2)CC1 CHEMBL3903924 IC50 3.67 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cnc3ccccc3c2)cc1 CHEMBL3935753 IC50 3.7 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cn1)N1Cc2ccncc2C1 CHEMBL3894770 IC50 3.7 nM
O=C(NCC1CCCC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3934532 IC50 3.71 nM
O=C(Nc1ccc(C(=O)N2CCN(c3ccccn3)CC2)cn1)N1Cc2ccccc2C1 CHEMBL3921797 IC50 3.73 nM
O=C(Nc1ccc(C2=CCN(C(=O)[C@@H]3CCOC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3911072 IC50 3.75 nM
Cn1cnc2cc(Cl)c(NCc3ccc(C(=O)NCc4cccnc4)cc3)cc2c1=O CHEMBL1801861 IC50 3.8 nM
Cc1nn(C(C)C)cc1S(=O)(=O)c1ccc(NC(=O)[C@@H]2C[C@H]2c2cccnc2)cc1 CHEMBL3127493 IC50 3.8 nM
Cc1nc(C)c(C(=O)N2CCC3(CC2)CC3CNC(=O)N2Cc3ccncc3C2)s1 CHEMBL3923552 IC50 3.8 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3cccc(F)c3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3904179 IC50 3.89 nM
O=C(N[C@H]1CC[C@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1)[C@H]1CCCO1 CHEMBL3905623 IC50 3.89 nM
O=C(Nc1ccc(S(=O)(=O)c2ccccc2)cc1)[C@H]1C[C@@H]1c1cccnc1 CHEMBL3127521 IC50 3.9 nM
O=C(Nc1ccc(C2CCN(S(=O)(=O)C3CC3)CC2)cc1)N1Cc2ccc(F)cc2C1 CHEMBL4076064 Ki 3.9 nM
O=C(/C=C/c1cccnc1)OCCCCC1CCN(C(=O)c2cccc(N(CCCl)CCCl)c2)CC1 CHEMBL5416477 IC50 3.9 nM
O=C(NC[C@H]1CCN(C(=O)c2ccccc2)C1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3969109 IC50 3.95 nM
COC(C)(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3907281 IC50 3.97 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccoc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3973183 IC50 3.99 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N2CCCCCC2)cc1 CHEMBL2391557 IC50 4.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N[C@H]2CCC[C@H](O)C2)cc1 CHEMBL2393173 IC50 4.0 nM
N[C@H]1CC[C@H](NS(=O)(=O)c2ccc(NC(=O)NCc3cccnc3)cc2)CC1 CHEMBL2393171 IC50 4.0 nM
C[C@@H]1CN(S(=O)(=O)c2ccc(NC(=O)NCc3cccnc3)cc2)C[C@H](C)O1 CHEMBL2393190 IC50 4.0 nM
Cc1c(C(=O)N2CCC3(CC2)CC3CNC(=O)N2Cc3ccncc3C2)cnn1C CHEMBL3974268 IC50 4.0 nM
O=C(NCC1CCCOC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3958262 IC50 4.01 nM
CCC(C)(C)C(=O)N1CC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3892538 IC50 4.03 nM
O=C(NCC1CCCOC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3895350 IC50 4.12 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1ccccc1F CHEMBL3986641 IC50 4.12 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCCC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3943244 IC50 4.15 nM
O=C(/C=C/c1ccco1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3915476 IC50 4.16 nM
O=C(NCC1CCCC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3896526 IC50 4.17 nM
O=C(NCC1CCS(=O)(=O)C1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3981513 IC50 4.19 nM
C#CCN(Cc1ccccc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801560 IC50 4.2 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc3ccccc23)cc1 CHEMBL3977643 IC50 4.2 nM
CCOc1cc(Cl)ccc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3901370 IC50 4.2 nM
O=C(Nc1ccc(C(=O)N2CCN(c3nccc4occc34)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3961527 IC50 4.25 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccoc3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3985234 IC50 4.25 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)N[C@H](CO)c3ccccc3)cc1)C2 CHEMBL3908245 IC50 4.28 nM
CC(C)OC(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3939767 IC50 4.3 nM
CC1(C(=O)N2CCC(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)CC1 CHEMBL4105475 Ki 4.3 nM
Nc1ccc(CNC(=O)Nc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)cn1 CHEMBL4213004 IC50 4.3 nM
COc1ccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)cc1 CHEMBL3923893 IC50 4.34 nM
O=C(Nc1ccc(C(=O)N2CCN(c3ccccn3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3931519 IC50 4.35 nM
O=C(Nc1ccc(C2CCN(C(=O)[C@H]3CCOC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3971642 IC50 4.38 nM
O=C(NCCCCC1CCN(C(=O)C2CCC(F)(F)CC2)CC1)N1Cc2ccncc2C1 CHEMBL3906982 IC50 4.38 nM
N#C/N=C(\NCCCCCCCC(=O)N(Cc1ccccc1)OCCN1CCOCC1)Nc1ccncc1 CHEMBL3094251 IC50 4.4 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1)Nc1ccncc1 CHEMBL3098609 IC50 4.4 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)N2CC3CCC(C2)O3)cc1)Nc1cccnc1 CHEMBL3098513 IC50 4.4 nM
CS(=O)(=O)c1cccc(S(=O)(=O)c2ccc(NC(=O)[C@@H]3C[C@H]3c3cccnc3)cc2)c1 CHEMBL3127500 IC50 4.4 nM
CC(C)CC(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3925878 IC50 4.4 nM
Cc1ccnn1CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3894499 IC50 4.4 nM
COc1ccccc1C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3907811 IC50 4.45 nM
O=C(NCC1CCC2(CCNCC2)CO1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3893668 IC50 4.45 nM
COc1ccc(NC(=O)c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)cn1 CHEMBL3967630 IC50 4.46 nM
O=C(NCCCc1ccccc1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3907075 IC50 4.47 nM
COc1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3913420 IC50 4.48 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cc1)c1cnc2[nH]ncc2c1 CHEMBL3260362 IC50 4.5 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2ccc(-c3ccccc3)cc2)cc1 CHEMBL3889466 IC50 4.5 nM
CN1CCC(CNC(=O)c2ccc(NC(=O)N3Cc4ccc(C#N)cc4C3)cc2)C1 CHEMBL3931915 IC50 4.54 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccncn3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3925757 IC50 4.55 nM
COc1cccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)c1 CHEMBL3915002 IC50 4.55 nM
COCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3958710 IC50 4.57 nM
COc1ccc(Cl)cc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3919231 IC50 4.6 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)N3CCN(c4ccccn4)CC3)cc1)C2 CHEMBL3913092 IC50 4.6 nM
COc1cccc(S(=O)(=O)c2ccc(CNC(=O)c3cnc4nccn4c3)nc2)c1 CHEMBL3944555 IC50 4.6 nM
COc1ccc(OC)c(C(=O)NCCCCCCNC(=O)N2Cc3ccccc3C2)c1 CHEMBL3929748 IC50 4.61 nM
O=C(Nc1ccc(CCN(CCCN2CCOCC2)Cc2ccccc2)cc1)N1Cc2ccccc2C1 CHEMBL3934100 IC50 4.65 nM
O=C(NCCCCC1CCN(C(=O)c2ccccc2)CC1)[C@@H]1C[C@H]1c1cccnc1 CHEMBL3127497 IC50 4.7 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccccn3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3916836 IC50 4.7 nM
O=C(Nc1ccc(C2=CCN(C(=O)[C@H]3CCCO3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3936596 IC50 4.7 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cn1)c1cnc2nccn2c1 CHEMBL3898624 IC50 4.7 nM
O=C(N[C@H]1CC[C@@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1)C1CCCCC1 CHEMBL3927873 IC50 4.71 nM
O=C(CC1CC1)N[C@H]1CC[C@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3929954 IC50 4.72 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3cscn3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3943701 IC50 4.79 nM
CC1(OC(=O)N2CCC3(CC2)CC3CNC(=O)N2Cc3ccncc3C2)CCC1 CHEMBL3948512 IC50 4.8 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc(-n3cccn3)c2)cc1 CHEMBL3965163 IC50 4.8 nM
O=C(NCc1ccc([S+]([O-])c2cc(F)cc(F)c2)cn1)c1cc2ccncc2o1 CHEMBL3394736 IC50 4.8 nM
O=C(CC1CCCCO1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3901932 IC50 4.82 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3COCCO3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3967908 IC50 4.83 nM
O=C(Nc1ccc(C2CCN(C(=O)C3COCCO3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3893765 IC50 4.86 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCS(=O)(=O)CC3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3901169 IC50 4.86 nM
O=C(NCc1ccccn1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3901617 IC50 4.88 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccccc3)CC2)nc1)N1Cc2ccncc2C1 CHEMBL3917797 IC50 4.88 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3cnco3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3892947 IC50 4.88 nM
CC(C)(C)CC(=O)N1CC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3928187 IC50 4.89 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc3c2OCC3)cc1 CHEMBL3897752 IC50 4.9 nM
O=C(NCCCCCCNC(=O)N1Cc2ccc(Cl)cc2C1)c1cccnc1 CHEMBL3951685 IC50 4.9 nM
O=C(NCc1cccs1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3924546 IC50 4.9 nM
CN(C)c1ncc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)s1 CHEMBL3933613 IC50 4.9 nM
O=C(NCCCCCCCn1cc(-c2cccnc2)nn1)c1ccccc1-c1ccccc1 CHEMBL4061448 IC50 4.9 nM
CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(CO)cc3C2)cc1 CHEMBL3913732 Ki 4.9 nM
COCC(C)(C)CNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3969080 IC50 4.91 nM
Cn1ccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)n1 CHEMBL3896888 IC50 4.92 nM
O=C(NCCC1CCOCC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3916084 IC50 4.94 nM
N#C/N=C(\NCCCCCCn1cc(CN(Cc2ccco2)C2CCCC2)nn1)Nc1ccncc1 CHEMBL5416318 IC50 4.98 nM
CC1CCN(S(=O)(=O)c2ccc(NC(=O)NCc3cccnc3)cc2)CC1 CHEMBL2391565 IC50 5.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1 CHEMBL2391574 IC50 5.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N2CCC3(CCNCC3)C2)cc1 CHEMBL2393164 IC50 5.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cc2ccncc2o1 CHEMBL2420624 IC50 5.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(F)c2)cc1)c1cc2cnccc2[nH]1 CHEMBL2420651 IC50 5.0 nM
CC(C)n1cc(S(=O)(=O)c2ccc(NC(=O)[C@H]3C[C@@H]3c3cccnc3)cc2)cn1 CHEMBL3127510 IC50 5.0 nM
CN=S(=O)(c1ccccc1)c1ccc(CNC(=O)c2cc3ccncc3o2)cc1 CHEMBL3394727 IC50 5.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)c1cc2cnccc2[nH]1 CHEMBL2420620 IC50 5.0 nM
CC(C)C(=O)N[C@H]1CC[C@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3971984 IC50 5.01 nM
O=C(NCc1ccccc1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3919686 IC50 5.02 nM
Cc1ccccc1NS(=O)(=O)c1cccc(CCCCCCNC(=O)/C=C/c2cccnc2)c1 CHEMBL4475995 IC50 5.08 nM
CCCn1cc(S(=O)(=O)c2ccc(NC(=O)[C@H]3C[C@@H]3c3cccnc3)cc2)cn1 CHEMBL3127507 IC50 5.1 nM
CN(C)c1ccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cn1 CHEMBL3913718 IC50 5.1 nM
CC1(C(=O)N2CCC(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)COC1 CHEMBL4086819 Ki 5.1 nM
Cc1cc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)c(C)[nH]1 CHEMBL3958714 IC50 5.11 nM
COC(NC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1)C(C)(C)C CHEMBL3958052 IC50 5.15 nM
O=C(CC1CC1)N1CCC(CCCCNC(=O)N2Cc3ccncc3C2)CC1 CHEMBL3891394 IC50 5.15 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3954816 IC50 5.24 nM
O=C(NCc1ccc(S(=O)(=O)C2CCN(CC(F)(F)F)CC2)cn1)c1cc2ccncc2o1 CHEMBL3947635 IC50 5.24 nM
COc1ccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)cc1OC CHEMBL3947487 IC50 5.25 nM
CC(C)(O)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3929302 IC50 5.28 nM
CN1CCC(c2ccc(C(=O)N3CCC4(CC3)CC4CNC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3914526 IC50 5.3 nM
CCOCCC(=O)Nc1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3963471 IC50 5.34 nM
Cc1ncsc1C(=O)N1CCC(CCCCNC(=O)c2cc3cnccc3[nH]2)CC1 CHEMBL2417798 IC50 5.4 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)C2CCCCC2)cc1)Nc1ccncc1 CHEMBL3098515 IC50 5.4 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2ccc3ncccc3c2)cc1 CHEMBL3916786 IC50 5.4 nM
CC(C)Oc1ccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cc1 CHEMBL3901440 IC50 5.4 nM
CN(C)c1ccc(S(=O)(=O)c2ccc(CNC(=O)c3cnc4nccn4c3)nc2)cn1 CHEMBL3944220 IC50 5.4 nM
CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)nc1 CHEMBL3984857 Ki 5.4 nM
COC(=O)c1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3931034 IC50 5.41 nM
CC(C)CC(=O)N1CC[C@@H](Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3897327 IC50 5.41 nM
O=C(NCc1cccnc1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3906557 IC50 5.44 nM
O=C(NCc1ccc(N2CCOCC2)cc1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3961147 IC50 5.48 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1ccccc1O CHEMBL3934267 IC50 5.49 nM
O=C(CCC(F)(F)F)N1CCC(CCCCNC(=O)N2Cc3ccncc3C2)CC1 CHEMBL3950385 IC50 5.5 nM
Cc1noc(C)c1C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3969804 IC50 5.57 nM
O=C(NCCCCC1CCN(C(=O)c2ccccn2)CC1)N1Cc2ccccc2C1 CHEMBL3915480 IC50 5.58 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5394343 IC50 5.59 nM
CCCOc1ccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cc1Cl CHEMBL3949336 IC50 5.6 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cn1)c1cc2ccncc2o1 CHEMBL3394734 IC50 5.6 nM
CC(C)(O)CC(=O)N1CCC(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL4082366 Ki 5.6 nM
CC(C)C(=O)N1CC[C@H](CNC(=O)c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3939552 IC50 5.67 nM
CC(C)C(=O)N1CCC(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3937701 IC50 5.68 nM
NC(=O)c1ccccc1CNC(=O)c1ccc(NC(=O)N2Cc3cccnc3C2)cc1 CHEMBL3937420 IC50 5.69 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccsc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3931219 IC50 5.71 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3COCCO3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3977930 IC50 5.73 nM
O=C(NC1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1)c1ccccc1 CHEMBL3915351 IC50 5.77 nM
O=C(CCC1CCOCC1)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3889487 IC50 5.8 nM
COc1ccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cc1Cl CHEMBL3906758 IC50 5.8 nM
O=C(CC1CC1)NC1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3980849 IC50 5.8 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCOCC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3916354 IC50 5.81 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCOCC3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3984572 IC50 5.81 nM
O=C(NCC1CCCCO1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3986968 IC50 5.82 nM
COCc1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3984840 IC50 5.84 nM
O=C(NCCCCC1CCN(C(=O)C2CCCCC2)CC1)N1Cc2ccncc2C1 CHEMBL3977590 IC50 5.84 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1cccc(O)c1 CHEMBL3909907 IC50 5.85 nM
Cc1cnc(C(=O)N2CC(Oc3ccc(NC(=O)N4Cc5ccncc5C4)cc3)C2)cn1 CHEMBL3900854 IC50 5.85 nM
O=C(NC[C@@H]1CCCO1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3944138 IC50 5.89 nM
COc1ccc2cc(S(=O)(=O)c3ccc(NC(=O)/C=C/c4cccnc4)cc3)ccc2c1 CHEMBL3938435 IC50 5.9 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc(C(=O)NC3CC3)c2)cc1 CHEMBL3972610 IC50 5.9 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(N3CCOCC3)c2)cn1)c1cc2ccncc2o1 CHEMBL3976902 IC50 5.9 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)cc2)cn1)N1Cc2ccncc2C1 CHEMBL3951544 IC50 5.9 nM
O=C(/C=C/c1cccnc1)NCCCCC1CCN(C(=O)c2cccc(CNC(=O)COCCOCCNC(=O)C3C(C(=O)O)C(C(=O)O)C3C(=O)O)c2)CC1 CHEMBL4462657 Ki 5.9 nM
CCC(CC)C(=O)N1CC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3951887 IC50 5.92 nM
Cc1cccc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)c1 CHEMBL3932831 IC50 5.97 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N2CCC3(CCNC3)CC2)cc1 CHEMBL2393163 IC50 6.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cc1)c1ccc2nccn2c1 CHEMBL2420631 IC50 6.0 nM
O=C(NCc1ccc([S@@+]([O-])c2cc(F)cc(F)c2)cn1)c1cc2ccncc2o1 CHEMBL3897803 IC50 6.0 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCS(=O)(=O)C3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3939865 IC50 6.01 nM
CC(C)CCN(Cc1ccccc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1 CHEMBL1801559 IC50 6.1 nM
CNC(=O)c1cccc(NC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)c1 CHEMBL3961731 IC50 6.1 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cn1)c1cc2ccncc2o1 CHEMBL3945117 IC50 6.1 nM
COc1cccc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)c1 CHEMBL3959602 IC50 6.1 nM
CC(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3955814 IC50 6.11 nM
O=C(NCCCCCCNC(=O)N1Cc2ccc(F)cc2C1)c1cccnc1 CHEMBL3915932 IC50 6.16 nM
Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)N3CCN(c4ccccn4)CC3)cc1)C2 CHEMBL3908237 IC50 6.18 nM
CCCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3928196 IC50 6.18 nM
CC(C)(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3930470 IC50 6.19 nM
Cc1nn(C)c(C)c1C(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3949594 IC50 6.2 nM
Cc1cc(Cl)cc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3966604 IC50 6.2 nM
O=C(Nc1ccc(OC2CCN(S(=O)(=O)c3ccccc3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3896930 IC50 6.22 nM
O=C(NCC1CCCCO1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3892281 IC50 6.24 nM
O=C(NCc1cccnc1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3938089 IC50 6.25 nM
O=C(NCCCCC1CCN(C(=O)c2ccccc2)CC1)c1cc2ccncc2s1 CHEMBL2417799 IC50 6.3 nM
COCCOCC(=O)N[C@H]1CC[C@@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3947327 IC50 6.3 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCCCCO)cc1)C2 CHEMBL3939782 IC50 6.31 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCS(=O)(=O)CC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3963129 IC50 6.31 nM
O=C(Nc1ccc(C2CCN(C(=O)C3CCOC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3900104 IC50 6.38 nM
Cc1ccncc1C(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3940454 IC50 6.5 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cn1)c1cnc2nccn2c1 CHEMBL3946245 IC50 6.5 nM
CCCn1cc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)cn1 CHEMBL3394741 IC50 6.5 nM
CC(C)OCC(=O)N1CCC(CCCCNC(=O)N2Cc3ccncc3C2)CC1 CHEMBL3892542 IC50 6.54 nM
O=C(Nc1ccc(C(=O)N2CCN(c3nccc4sccc34)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3956181 IC50 6.56 nM
O=C(NCCCc1ccccc1)c1ccc(NC(=O)N2Cc3ccccc3C2)nc1 CHEMBL3946158 IC50 6.56 nM
CC(C)(C)OCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3897885 IC50 6.56 nM
O=C(Nc1ccc(S(=O)(=O)c2cnn(C3CCOCC3)c2)cc1)[C@@H]1C[C@H]1c1cccnc1 CHEMBL3127494 IC50 6.6 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)N3CCN(C(=O)c4ccco4)CC3)cc1)C2 CHEMBL3982642 IC50 6.6 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cn1)c1cc2ccncc2o1 CHEMBL3394733 IC50 6.6 nM
CN(C)c1ncc(S(=O)(=O)c2ccc(CNC(=O)N3Cc4ccncc4C3)nc2)s1 CHEMBL3977371 IC50 6.6 nM
CN1CCC(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)CC1 CHEMBL3949693 IC50 6.61 nM
Cn1cccc1CNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3970357 IC50 6.62 nM
O=C(Cc1ccsc1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3911329 IC50 6.64 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccccc3)CC2)nc1)N1Cc2ccccc2C1 CHEMBL3977251 IC50 6.69 nM
COc1c(C)cc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cc1C CHEMBL3961926 IC50 6.7 nM
Cn1cc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)cn1 CHEMBL3928705 IC50 6.7 nM
c1ccc(-c2ccccc2OCCCCCCn2cc(-c3cccnc3)nn2)cc1 CHEMBL4074848 IC50 6.7 nM
O=C(CCCc1cccs1)Nc1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3956537 IC50 6.73 nM
O=C(Nc1ccc(C2CCN(C(=O)[C@@H]3CCOC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3933737 IC50 6.76 nM
Cc1ccc(C(CO)NC(=O)c2ccc(NC(=O)N3Cc4ccc(C#N)cc4C3)cc2)cc1 CHEMBL3939923 IC50 6.79 nM
CCS(=O)(=O)c1cccc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)c1 CHEMBL3957389 IC50 6.8 nM
O=C(CC1CCCO1)NC1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3920749 IC50 6.82 nM
CS(=O)(=O)N1CCC(CNC(=O)c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3977555 IC50 6.83 nM
CCN(C)c1ncc(S(=O)(=O)c2ccc(CNC(=O)N3Cc4ccncc4C3)nc2)s1 CHEMBL3960842 IC50 6.83 nM
O=C(CC1CCOCC1)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3904503 IC50 6.9 nM
O=C(CC1CCOC1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3923512 IC50 6.9 nM
O=C(Nc1ccc(OC2CCN(S(=O)(=O)c3cccs3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3977306 IC50 6.9 nM
CCCC(C)C(=O)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3968071 IC50 6.9 nM
CN1CCN(c2ccc(S(=O)(=O)c3ccc(CNC(=O)c4ccc5nccn5c4)nc3)cn2)CC1 CHEMBL3931704 IC50 6.9 nM
CCCNC(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3934028 IC50 6.92 nM
CCOCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3953587 IC50 6.94 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1cccc(Cl)c1 CHEMBL3980425 IC50 6.98 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N2CC3CCC(C2)O3)cc1 CHEMBL2391568 IC50 7.0 nM
Cn1cc(S(=O)(=O)c2ccc(NC(=O)NCc3cccnc3)cc2)cn1 CHEMBL2391573 IC50 7.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1 CHEMBL2391570 IC50 7.0 nM
O=S(=O)(c1ccc(NC(=S)NCc2cccnc2)cc1)N1CCCCC1 CHEMBL1586371 IC50 7.0 nM
Cc1cncc(CNC(=O)Nc2ccc(S(=O)(=O)c3ccccc3)cc2)c1 CHEMBL2393176 IC50 7.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cc1)c1cc2cnccc2[nH]1 CHEMBL2420622 IC50 7.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)c1cc2ccncc2s1 CHEMBL2420659 IC50 7.0 nM
CC(C)n1cc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4s3)nc2)cn1 CHEMBL3394740 IC50 7.0 nM
O=C(Nc1ccc(S(=O)(=O)c2ccccc2)cc1)/C(F)=C/c1cccnc1 CHEMBL3954839 IC50 7.0 nM
O=C(CCCCCN(Cc1ccc(F)cc1)c1ncc(C(=O)NCCCn2ccnc2)s1)NO CHEMBL4171570 IC50 7.0 nM
CC(=O)NCc1ccc2c(c1)CN(C(=O)Nc1ccc(NC(=O)CC3CCCC3)cc1)C2 CHEMBL3973581 IC50 7.08 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)N1Cc2ccncc2C1 CHEMBL2419514 IC50 7.1 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cn1)c1ccc2nccn2c1 CHEMBL3976797 IC50 7.1 nM
Cc1ncsc1-c1ccc(C(C)NC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOCCOCCOCCNC(=O)c2ccc(CN3CCN(S(=O)(=O)c4ccc(NC(=S)NCc5ccccc5)cc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5266272 EC50 7.1 nM
C[C@@H](O)CNC(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3952836 IC50 7.13 nM
COCCOCC(=O)N[C@H]1CC[C@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3920370 IC50 7.14 nM
CCCn1cc(S(=O)(=O)c2ccc(NC(=O)[C@@H]3C[C@H]3c3cccnc3)cc2)cn1 CHEMBL3127506 IC50 7.2 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc3c2Oc2ccccc2S3)cc1 CHEMBL3963467 IC50 7.2 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)cc2)cn1)c1ccc2nccn2c1 CHEMBL3900480 IC50 7.2 nM
COc1cc(Cl)ccc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3960468 IC50 7.3 nM
CCNC(=O)c1cccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3973586 IC50 7.3 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCNC(=O)c2ccc(C(=O)N3CCC(CCCCNC(=O)/C=C/c4cccnc4)CC3)cc2)C(C)(C)C)cc1 CHEMBL5408297 IC50 7.3 nM
O=C(NC1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1)C1CCCO1 CHEMBL3911820 IC50 7.33 nM
COC(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3955004 IC50 7.37 nM
CCS(=O)(=O)N1CCN(C(=O)c2ccc(NC(=O)N3Cc4ccc(C#N)cc4C3)cc2)CC1 CHEMBL3906171 IC50 7.37 nM
O=C(NCc1ccc(S(=O)(=O)N2CCC(N3CCCC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL2419536 IC50 7.4 nM
Cc1ccc(F)cc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3926482 IC50 7.4 nM
O=C(Nc1ccc(C2CCN(C(=O)C3CCOCC3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3959243 IC50 7.4 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCCO3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3891831 IC50 7.42 nM
O=C(NCC1CCOC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3985246 IC50 7.43 nM
O=C(NCCCCC1CN(C(=O)c2ccccc2)C1)N1Cc2ccncc2C1 CHEMBL3941682 IC50 7.44 nM
O=C(NCc1ccncc1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3895584 IC50 7.46 nM
O=C(NCCCCc1ccccc1)N1Cc2ccncc2C1 CHEMBL3953649 IC50 7.46 nM
N#C/N=C(\NCc1ccc(S(=O)(=O)Cc2ccccc2)cc1)Nc1ccncc1 CHEMBL3098514 IC50 7.5 nM
Cc1nn(C)cc1C(=O)N1CCC2(CC1)CC2CNC(=O)N1Cc2ccncc2C1 CHEMBL3921809 IC50 7.5 nM
CS(=O)(=O)Nc1cccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3907988 IC50 7.5 nM
CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3908312 Ki 7.5 nM
O=C(NCc1ccc(N2CCOCC2)cc1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3976934 IC50 7.52 nM
CCCS(=O)(=O)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3953369 IC50 7.53 nM
CC(C)CCNC(=O)c1cnc(NC(=O)N2Cc3ccccc3C2)cn1 CHEMBL3940814 IC50 7.55 nM
COCCOCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3984102 IC50 7.55 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1ccccc1 CHEMBL3923569 IC50 7.59 nM
O=C(NC[C@@H]1CCOC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3932193 IC50 7.59 nM
O=C(NCCCCCCOc1ccc(Cl)cc1)[C@@H]1C[C@H]1c1cccnc1 CHEMBL3127498 IC50 7.6 nM
O=C(CCCCCc1cn(-c2ccccc2-c2ccccc2)nn1)NCCc1cccnc1 CHEMBL3752157 IC50 7.6 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(CO)cc3C2)cc1 CHEMBL3925651 IC50 7.62 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)N1Cc2ccccc2C1 CHEMBL3944806 IC50 7.63 nM
CC(C)CC(=O)NC1(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)COC1 CHEMBL3972992 IC50 7.65 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1)c1cnc2[nH]ncc2c1 CHEMBL3260359 IC50 7.7 nM
COCc1cccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3934921 IC50 7.7 nM
Cn1cc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cn1 CHEMBL3906757 IC50 7.7 nM
COc1ccccc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3958962 IC50 7.7 nM
Cc1cc(CNC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)no1 CHEMBL3958028 IC50 7.76 nM
O=C(Nc1ccc(S(=O)(=O)c2ccccc2)cc1)[C@@H]1C[C@H]1c1cccnc1 CHEMBL3127520 IC50 7.8 nM
CCOCc1ccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cc1 CHEMBL3913605 IC50 7.8 nM
CN(C)c1ncc(S(=O)(=O)c2ccc(CNC(=O)c3ccc4nccn4c3)nc2)s1 CHEMBL3929667 IC50 7.8 nM
c1ccc(-c2ccccc2-c2cn(CCCCCCCn3cc(-c4cccnc4)nn3)nn2)cc1 CHEMBL4066091 IC50 7.8 nM
COc1ccc(CCNC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)cc1OC CHEMBL3948524 IC50 7.84 nM
O=C(Nc1ccc(C2CCN(C(=O)[C@@H]3CCCO3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3949125 IC50 7.84 nM
O=C(NCCCCC1CCN(C(=O)[C@H]2CCCO2)CC1)N1Cc2ccncc2C1 CHEMBL3938168 IC50 7.84 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)c1cnc2[nH]ncc2c1 CHEMBL3260357 IC50 7.9 nM
CN(C)c1ncc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cn1 CHEMBL3975546 IC50 7.9 nM
CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3926822 Ki 7.9 nM
O=C(/C=C/c1cccnc1)NCCCCC1CCN(C(=O)c2cccc(CNC(=O)COCCOCCNC(=O)CS(=O)(=O)O)c2)CC1 CHEMBL4452074 Ki 7.9 nM
COCCOCC(=O)NC1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3948549 IC50 7.95 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N[C@H]2CC[C@H](O)CC2)cc1 CHEMBL2393172 IC50 8.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)N[C@@H]2CCNC[C@H]2F)cc1 CHEMBL2393169 IC50 8.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1ccc2nccn2c1 CHEMBL2420630 IC50 8.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cc2cnccc2[nH]1 CHEMBL2420649 IC50 8.0 nM
Cc1cccc(S(=O)(=O)c2ccc(CNC(=O)c3cc4cnccc4[nH]3)cc2)c1 CHEMBL2420647 IC50 8.0 nM
O=C(NCc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1cc2cccnc2s1 CHEMBL2420661 IC50 8.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)N1Cc2ccncc2C1 CHEMBL2419512 IC50 8.0 nM
CC(C)CN1CCC([S+]([O-])c2ccc(CNC(=O)c3cc4ccncc4o3)cc2)CC1 CHEMBL3394724 IC50 8.0 nM
O=C(N[C@H](CO)c1ccccc1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3951228 IC50 8.0 nM
O=C(NCc1ccc([S+]([O-])c2cccc(OC(F)(F)F)c2)cn1)N1Cc2ccncc2C1 CHEMBL3964015 IC50 8.0 nM
O=C(Cc1ccccc1)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3912627 IC50 8.02 nM
COc1cccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)c1OC CHEMBL3900549 IC50 8.07 nM
O=C(Nc1ccc(C2=CCN(Cc3ccccc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3922716 IC50 8.07 nM
O=C(NCC1CCOCC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3959913 IC50 8.08 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cc(Cl)cc(C(F)(F)F)c2)cc1 CHEMBL3956009 IC50 8.1 nM
CCS(=O)(=O)Nc1cccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3984517 IC50 8.1 nM
COc1cccc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)c1 CHEMBL3935764 IC50 8.11 nM
O=C(CCC(F)(F)F)Nc1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3891086 IC50 8.14 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1cccc(F)c1 CHEMBL3916913 IC50 8.14 nM
COCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3982299 IC50 8.15 nM
O=C(CCCCCCNC(=S)NCc1cccnc1)N(OCCN1CCOCC1)C1CCCCC1 CHEMBL3094236 IC50 8.2 nM
O=C(NCc1ccc(S(=O)(=O)c2cnc3ccccc3c2)cc1)c1cnc2[nH]ncc2c1 CHEMBL3260364 IC50 8.2 nM
O=C(NCC1CCC2(CCNCC2)CO1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3970696 IC50 8.2 nM
O=C(NCCCCC1CCN(C(=O)[C@@H]2CCCO2)CC1)N1Cc2ccncc2C1 CHEMBL3969127 IC50 8.2 nM
O=C(Nc1ccc(C2=CCN(C(=O)C3CCOC3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3969053 IC50 8.23 nM
Cc1cc(CNC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)on1 CHEMBL3972622 IC50 8.24 nM
O=C(NCCCCC1CCN(C(=O)c2cccnc2)CC1)N1Cc2ccccc2C1 CHEMBL3969129 IC50 8.25 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccncc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3922300 IC50 8.25 nM
CCCCS(=O)(=O)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3905868 IC50 8.26 nM
O=C(CN1CCCC1)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3937013 IC50 8.31 nM
CC[C@H](C)C(=O)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3957059 IC50 8.31 nM
O=C(Nc1ccc(C2CCN(C(=O)C3CCCO3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3906958 IC50 8.32 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1cccc(C(F)(F)F)c1 CHEMBL3936306 IC50 8.39 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc3cc[nH]c23)cc1 CHEMBL3974144 IC50 8.4 nM
CCCn1c(=O)c(-c2ccc(C(=O)NCc3cccnc3)cc2)nc2ccc(NC(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(-c4scnc4C)cc3)C(C)(C)C)cc21 CHEMBL5205757 DC50 8.4 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccn[nH]3)CC2)cc1)N1Cc2ccncc2C1 CHEMBL3974320 IC50 8.44 nM
CN1CCC[C@H]1C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3965162 IC50 8.44 nM
CC(C)C[C@@H](CO)NC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3944862 IC50 8.45 nM
O=C(Nc1ccc(N2CCN(C(=O)c3ccccc3Cl)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3978418 IC50 8.47 nM
O=C(CC1CC1)NC1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3956067 IC50 8.47 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cn1)c1ccc2nccn2c1 CHEMBL3931302 IC50 8.5 nM
Cc1ccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)cc1Cl CHEMBL3931218 IC50 8.6 nM
O=C(NCc1ccc(S(=O)(=O)c2ccc(N3CCOCC3)nc2)cn1)c1ccc2nccn2c1 CHEMBL3917703 IC50 8.6 nM
O=C(NCCC1CCCOC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3979553 IC50 8.67 nM
CC(C)COCCCNC(=O)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3899935 IC50 8.68 nM
CC(C)C(=O)N[C@@H]1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3895412 IC50 8.72 nM
Cc1ccc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)cc1 CHEMBL3894731 IC50 8.74 nM
O=C(CCCc1ccccc1)Nc1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3962028 IC50 8.77 nM
CC(C)COCC(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3912392 IC50 8.77 nM
CC(C)(O)CNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3948230 IC50 8.78 nM
O=C(Nc1ccc(S(=O)(=O)N2CC3CCC(C2)O3)cc1)[C@@H]1C[C@H]1c1cccnc1 CHEMBL3127525 IC50 8.8 nM
O=C(N[C@H]1CC[C@H](c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1)[C@@H]1CCCO1 CHEMBL3966046 IC50 8.81 nM
CC(C)CCNS(=O)(=O)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3953984 IC50 8.82 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3cccnc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3944747 IC50 8.84 nM
O=C(NCCCc1ccccc1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3928768 IC50 8.88 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCC(O)CO)cc1)C2 CHEMBL3946262 IC50 8.88 nM
O=C(NCCCCC1CN(C(=O)c2ccccc2)C1)N1Cc2ccccc2C1 CHEMBL3960869 IC50 8.88 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(-c3c[nH]c(=O)c4ccccc34)cc1)C2 CHEMBL3918406 IC50 8.89 nM
Cn1ncc2cccc(S(=O)(=O)c3ccc(NC(=O)/C=C/c4cccnc4)cc3)c21 CHEMBL3934937 IC50 8.9 nM
CC1CCCN(S(=O)(=O)c2ccc(NC(=O)NCc3cccnc3)cc2)C1 CHEMBL2391564 IC50 9.0 nM
CCCCNS(=O)(=O)c1ccc(NC(=O)NCc2cccnc2)cc1 CHEMBL2391560 IC50 9.0 nM
O=C(NCc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1cc2cnccc2[nH]1 CHEMBL2420670 IC50 9.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)c1cc2ccncc2o1 CHEMBL2419504 IC50 9.0 nM
CCn1cc(S(=O)(=O)c2ccc(NC(=O)[C@@H]3C[C@H]3c3cccnc3)cc2)cn1 CHEMBL3127504 IC50 9.0 nM
CC(C)(C)OC(=O)N1CCC2(CC1)CC2CNC(=O)c1cc2ccncc2s1 CHEMBL3902837 IC50 9.0 nM
Cc1ncccc1S(=O)(=O)c1ccc(NC(=O)/C=C/c2cccnc2)cc1 CHEMBL3924819 IC50 9.0 nM
O=C(Nc1ccc(C2=CCN(C(=O)c3ccc(F)cc3)CC2)cc1)N1Cc2ccccc2C1 CHEMBL3960840 IC50 9.0 nM
CCC(C)C(=O)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3930735 IC50 9.0 nM
O=C(NCCCc1ccccc1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3938019 Ki 9.0 nM
O=C(NCCCCCCNC(=O)N1Cc2ccccc2C1)c1ccccc1Cl CHEMBL3897694 IC50 9.05 nM
Cc1cc(C)n(-c2cccc(S(=O)(=O)c3ccc(NC(=O)/C=C/c4cccnc4)cc3)c2)n1 CHEMBL3929455 IC50 9.1 nM
CN(C)c1ccc(S(=O)(=O)c2ccc(CNC(=O)c3ccc4nccn4c3)nc2)cn1 CHEMBL3946487 IC50 9.1 nM
O=C(N[C@H](CO)c1ccccc1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3932411 IC50 9.13 nM
O=C(NCC1CCC2(CCNCC2)O1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 CHEMBL3979639 IC50 9.13 nM
CC(C)OCCNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3902765 IC50 9.15 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(C(=O)NCCCN3CCCCC3)cc1)C2 CHEMBL3945112 IC50 9.18 nM
CC[C@@H](CO)NC(=O)c1ccc(NC(=O)N2Cc3ccc(C#N)cc3C2)cc1 CHEMBL3930855 IC50 9.18 nM
O=C(N[C@H](CO)c1ccc2c(c1)OCO2)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3963038 IC50 9.19 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2cccc(N3CCOCC3)c2)cc1 CHEMBL3968045 IC50 9.2 nM
O=C(/C=C/c1cccnc1)NCCCCCCc1cccc(S(=O)(=O)Nc2ccc(F)cc2)c1 CHEMBL4579284 IC50 9.2 nM
COC1CCC(C(=O)N2CC(Oc3ccc(NC(=O)N4Cc5ccncc5C4)cc3)C2)CC1 CHEMBL3905620 IC50 9.24 nM
O=C(NC[C@H]1CCCO1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 CHEMBL3976481 IC50 9.33 nM
CN1CCC(C(=O)N2CCC(c3ccc(NC(=O)N4Cc5ccc(F)cc5C4)cc3)CC2)CC1 CHEMBL4077485 Ki 9.4 nM
O=C(CCc1ccccc1)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3897061 IC50 9.41 nM
O=C(NCc1ccc(S(=O)(=O)c2cnc(N3CCCC3)s2)cn1)c1cc2ccncc2o1 CHEMBL3953926 IC50 9.45 nM
CC(C)(C)c1ccc(NS(=O)(=O)c2cccc(CCCCCCNC(=O)/C=C/c3cccnc3)c2)cc1 CHEMBL4561168 IC50 9.47 nM
O=C(Nc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1)[C@@H]1C[C@H]1c1cccnc1 CHEMBL3127501 IC50 9.5 nM
Cc1ccn(CCNC(=O)c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)n1 CHEMBL3980189 IC50 9.54 nM
O=C(Nc1ccc(OC2CN(C(=O)c3ccco3)C2)cc1)N1Cc2ccncc2C1 CHEMBL3955582 IC50 9.56 nM
CCC(CNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1)OC CHEMBL3924935 IC50 9.62 nM
CC(C)(O)C(=O)N1CCC(c2ccc(NC(=O)N3Cc4ccccc4C3)cc2)CC1 CHEMBL3945125 IC50 9.63 nM
O=C(CC1CCCC1)N1CCC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1 CHEMBL3922987 IC50 9.68 nM
CC(C)(C)C(=O)N1CC(Oc2ccc(NC(=O)N3Cc4ccncc4C3)cc2)C1 CHEMBL3924856 IC50 9.68 nM
O=C(/C=C/c1cccnc1)NCCCCCCc1cccc(S(=O)(=O)Nc2ccc(F)c(Cl)c2)c1 CHEMBL4453985 IC50 9.7 nM
Nc1cccc(CNC(=O)c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)c1 CHEMBL3938960 IC50 9.71 nM
COc1cccc(C(=O)NCCCCCCNC(=O)N2Cc3ccccc3C2)c1 CHEMBL3978411 IC50 9.77 nM
O=C(CC1CCCC1)Nc1ccc(NC(=O)N2Cc3ccc(C(F)(F)F)cc3C2)cc1 CHEMBL3980399 IC50 9.77 nM
Cc1ccc(NS(=O)(=O)c2cccc(CCCCCCNC(=O)/C=C/c3cccnc3)c2)cc1 CHEMBL4453544 IC50 9.78 nM
O=C(NCC1CCC2(CCNCC2)O1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 CHEMBL3930756 IC50 9.88 nM
NS(=O)(=O)c1cccc(S(=O)(=O)c2ccc(NC(=O)/C=C/c3cccnc3)cc2)c1 CHEMBL3894735 IC50 9.9 nM
O=C(/C=C/c1cccnc1)Nc1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1 CHEMBL3944927 IC50 9.9 nM
O=C(NCc1ccc(N2CCOCC2)cc1)c1ccc(NC(=O)N2Cc3cccnc3C2)cc1 CHEMBL3900702 IC50 9.9 nM
O=C(Nc1ccc(C(=O)N2CCN(c3cccnn3)CC2)cc1)N1Cc2ccc(F)cc2C1 CHEMBL3940426 IC50 9.91 nM
CN(C)c1cccc(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccccc5C4)cc3)CC2)c1 CHEMBL3941298 IC50 9.96 nM
CN1CCC(C(=O)N2CC=C(c3ccc(NC(=O)N4Cc5ccncc5C4)cc3)CC2)C1 CHEMBL3907377 IC50 9.97 nM