NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667204 IC50 0.38 nM
CC(C)(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667261 IC50 0.43 nM
NCCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3667249 IC50 0.5 nM
C[C@@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667248 IC50 0.54 nM
NCC1CCN(Cc2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2F)CC1 CHEMBL3667234 IC50 0.57 nM
C[C@@H](CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672289 IC50 0.64 nM
CC(C)(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667250 IC50 0.67 nM
CC(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667224 IC50 0.73 nM
NCCCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667246 IC50 0.74 nM
CCC(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672360 IC50 0.74 nM
O=c1[nH]c2ccc(O)c(C3=CCNCC3)c2c2ccsc12 CHEMBL3667207 IC50 0.78 nM
NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)s1 CHEMBL3667241 IC50 0.78 nM
C[C@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667233 IC50 0.81 nM
CCC(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672235 IC50 0.82 nM
C[C@H](c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3667245 IC50 0.88 nM
CC[C@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672269 IC50 0.88 nM
CNCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667219 IC50 0.9 nM
CC(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672246 IC50 0.92 nM
O=c1[nH]c2ccc(O)c(-c3ccc(CN4CCC(O)C4)c(F)c3)c2c2ccsc12 CHEMBL3667251 IC50 0.97 nM
CC(C)(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672339 IC50 1.0 nM
NCCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667217 IC50 1.1 nM
CN[C@@H](C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672259 IC50 1.1 nM
NC1Cc2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2C1 CHEMBL3672240 IC50 1.2 nM
CN[C@H](C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672253 IC50 1.3 nM
CC(N)Cc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672263 IC50 1.3 nM
CC(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672266 IC50 1.3 nM
CC[C@@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672276 IC50 1.3 nM
CC[C@H](NC)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672283 IC50 1.3 nM
C[C@H](CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672292 IC50 1.3 nM
CNC[C@H](C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672301 IC50 1.3 nM
CCN[C@H](CC)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672274 IC50 1.4 nM
CC(C)C(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672329 IC50 1.4 nM
CC(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672297 IC50 1.5 nM
CC(c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3667221 IC50 1.6 nM
NCC1(c2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2)CCC1 CHEMBL3672355 IC50 1.7 nM
NS(=O)(=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667203 IC50 1.8 nM
CCC(CC)(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672310 IC50 1.8 nM
CN(C)CCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3667263 IC50 1.9 nM
CCC(c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3672238 IC50 1.9 nM
NCC1(c2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2)CC1 CHEMBL3672242 IC50 1.9 nM
CC(c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F)N(C)C CHEMBL3672243 IC50 1.9 nM
CCNCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667242 IC50 2.0 nM
CC(O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667259 IC50 2.0 nM
CC(NS(C)(=O)=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667222 IC50 2.0 nM
O=c1[nH]c2ccc(O)c(-c3ccc4c(c3)CNCC4)c2c2ccsc12 CHEMBL3672244 IC50 2.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)CN)cc1 CHEMBL3672290 IC50 2.0 nM
CC[C@@H](c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3672275 IC50 2.2 nM
Nc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1O CHEMBL3667229 IC50 2.3 nM
NCc1ccc(-c2c(O)cc(F)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667236 IC50 2.5 nM
CN[C@@H](C)c1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672255 IC50 2.5 nM
CC[C@H](c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3672285 IC50 2.5 nM
C[C@@H](CN(C)C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672302 IC50 2.5 nM
CS(=O)(=O)Nc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667205 IC50 2.6 nM
Cc1cc(O)c(-c2ccc([C@@H](C)CN)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672295 IC50 2.6 nM
CC(c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N1CCCC1 CHEMBL3667223 IC50 2.8 nM
CN(C)CC(C)(C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667258 IC50 2.8 nM
CC(NC1CCCC1)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667260 IC50 2.8 nM
CNC[C@@H](C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672307 IC50 2.8 nM
C[C@@H](c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3672234 IC50 2.9 nM
CC[C@H](N)c1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672270 IC50 2.9 nM
Cc1cc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)ccc1NS(C)(=O)=O CHEMBL3667235 IC50 3.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)CN)c(F)c1 CHEMBL3672299 IC50 3.0 nM
CNC[C@H](C)c1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672303 IC50 3.0 nM
Cc1cc(O)c(-c2ccc(CCN)c(Cl)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672336 IC50 3.0 nM
N#CCCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667252 IC50 3.2 nM
C[C@@H](NS(C)(=O)=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667256 IC50 3.2 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)CN)cc1 CHEMBL3672248 IC50 3.2 nM
CC(CN(C)C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672267 IC50 3.3 nM
Cc1cc(O)c(-c2ccc([C@@H](C)CN)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672367 IC50 3.4 nM
O=c1[nH]c2ccc(O)c(-c3ccc4cn[nH]c4c3)c2c2ccsc12 CHEMBL3667202 IC50 3.5 nM
CCN(CC)C(C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672245 IC50 3.6 nM
CN(C)CC1(c2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2)CC1 CHEMBL3672249 IC50 3.6 nM
CCC(c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(CC)CC CHEMBL3672237 IC50 3.7 nM
Cc1cc(O)c(-c2ccc([C@@H](C)CN)cc2)c2c1[nH]c(=O)c1sc(F)cc12 CHEMBL3672381 IC50 3.7 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(CCN)c(F)c1 CHEMBL3667240 IC50 3.8 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)N)cc1 CHEMBL3667247 IC50 3.8 nM
CCNC(C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672250 IC50 3.9 nM
NCCc1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1Cl CHEMBL3672338 IC50 3.9 nM
C[C@H](CN(C)C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672296 IC50 4.0 nM
Cc1cc(O)c(-c2ccc([C@@H](C)CN)cc2)c2c1[nH]c(=O)c1sc(Cl)cc12 CHEMBL3672375 IC50 4.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(CN)C(C)C)cc1 CHEMBL3672330 IC50 4.1 nM
CC(C)NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3639660 IC50 4.2 nM
CC(c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N1CCCCC1 CHEMBL3667239 IC50 4.3 nM
Cc1cc2c(s1)c(=O)[nH]c1ccc(O)c(-c3ccc(CN)cc3)c12 CHEMBL3667209 IC50 4.4 nM
C[C@@H](CN)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672294 IC50 4.4 nM
CCN(CC)C(C)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667225 IC50 4.5 nM
NCC(c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)C1CCCC1 CHEMBL3672323 IC50 4.6 nM
Cc1cc(O)c(-c2ccc(CCN)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672315 IC50 4.7 nM
Cc1cc(O)c(-c2ccc(C(C)CN)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672304 IC50 5.1 nM
CCC(N)c1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672236 IC50 5.2 nM
CN(C)CCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667208 IC50 5.4 nM
CS(=O)(=O)NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667227 IC50 5.5 nM
NCCc1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672317 IC50 5.5 nM
Cc1cc(O)c(-c2ccc([C@@H](C)N)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672271 IC50 5.9 nM
CCNCc1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667243 IC50 6.0 nM
NCCc1cc(Br)c(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1O CHEMBL3672318 IC50 6.4 nM
CN(C)Cc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667215 IC50 6.9 nM
CNC[C@H](C)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672359 IC50 7.3 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc([C@H](C)N)cc1 CHEMBL3667232 IC50 7.4 nM
CCN(CC)Cc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667218 IC50 7.7 nM
CNCc1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667220 IC50 7.8 nM
CNC[C@H](C)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672364 IC50 8.1 nM
Cc1cc(O)c(-c2ccc(C(C)(C)N)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672370 IC50 8.3 nM
C[C@@H](N)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672258 IC50 8.6 nM
CC(CN)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672280 IC50 8.6 nM
CNCC(C)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672351 IC50 8.9 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 9.1 nM
CC(c1ccc(-c2cccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3672241 IC50 9.2 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(CN2CCC(CNC(=O)OC(C)(C)C)CC2)cc1 CHEMBL3667211 IC50 9.4 nM
CC[C@H](NC)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672286 IC50 9.4 nM
Cc1cc(O)c(-c2ccc(C3(CN)CC3)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672331 IC50 9.6 nM
CC(C)(N)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672233 IC50 10.0 nM
O=c1[nH]c2ccc(O)c(-c3ccc(S(=O)(=O)NCCBr)cc3)c2c2c1CCC2 CHEMBL3672262 IC50 10.0 nM
CC(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1Cl CHEMBL3672344 IC50 10.0 nM
Cc1cc(O)c(-c2ccc(C3(CN)CCC3)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672349 IC50 10.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(CN(C)C)cc1 CHEMBL3667214 IC50 11.0 nM
COc1cc(C)c2[nH]c(=O)c3sc(Cl)cc3c2c1-c1ccc([C@@H](C)CN)cc1 CHEMBL3672376 IC50 11.0 nM
O=c1[nH]c2ccc(O)c(-c3ccc(S(=O)(=O)NCCBr)cc3)c2c2ccsc12 CHEMBL3667226 IC50 11.3 nM
COC(=O)c1cccc(-c2cnc3[nH]cc(-c4cccnc4)c3c2)c1 CHEMBL5087398 IC50 11.5 nM
N#CCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667206 IC50 12.0 nM
CS(=O)(=O)N1CCN(c2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2)CC1 CHEMBL3667210 IC50 12.0 nM
CC(N)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672252 IC50 12.0 nM
Cc1cc(O)c(-c2ccc(C(C)N)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672256 IC50 12.0 nM
CN[C@H](C)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672334 IC50 12.0 nM
Cc1cc2c(s1)c(=O)[nH]c1c(C)cc(O)c(-c3ccc([C@@H](C)CN)cc3)c12 CHEMBL3672371 IC50 12.0 nM
O=c1[nH]c2ccc(O)c(-c3ccc(S(=O)(=O)NCCBr)c(F)c3)c2c2ccsc12 CHEMBL3667254 IC50 13.0 nM
N#Cc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(CN)cc1 CHEMBL3667262 IC50 13.0 nM
O=c1[nH]c2ccc(O)c(-c3ccc(S(=O)(=O)NCCCl)cc3)c2c2c1CCC2 CHEMBL3672282 IC50 13.0 nM
CCC(C#N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672291 IC50 13.0 nM
Cc1cc(O)c(-c2ccc([C@H](C)CN)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672357 IC50 13.0 nM
CN[C@H](C)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672277 IC50 14.0 nM
N#CCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3667238 IC50 15.0 nM
CC(CCl)NS(=O)(=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672309 IC50 15.0 nM
CCC(CN)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672350 IC50 15.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)CN)cc1 CHEMBL3672358 IC50 15.0 nM
NCc1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667264 IC50 16.0 nM
CCC(N)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672261 IC50 16.0 nM
NCCc1cc(Cl)c(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1O CHEMBL3672311 IC50 16.0 nM
Cc1cc(O)c(-c2ccc([C@H](C)N)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672319 IC50 16.0 nM
Cc1cc(O)c(-c2ccc([C@H](C)CN)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672322 IC50 16.0 nM
C[C@@H](CN)c1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672298 IC50 17.0 nM
CNCC(c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1F)C(C)C CHEMBL3672352 IC50 17.0 nM
Cc1cc(O)c(-c2ccc([C@@H](C)CN(C)C)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672362 IC50 17.0 nM
CC[C@@H](N)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672287 IC50 18.0 nM
Cc1cc(O)c(-c2ccc(C(CN)C(C)C)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672341 IC50 18.0 nM
CN[C@@H](C)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672260 IC50 19.0 nM
Cc1cc(O)c(-c2ccc(CCN)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672305 IC50 19.0 nM
NCCc1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672312 IC50 19.0 nM
CCC(CN)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672363 IC50 19.0 nM
NCCc1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672278 IC50 20.0 nM
COc1cc(Cl)c2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)CN)cc1 CHEMBL3672308 IC50 20.0 nM
Cc1cc(O)c(-c2ccc(C(CN)C(C)C)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672348 IC50 20.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)N2CCCC2)cc1 CHEMBL3667228 IC50 21.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(CCN)cc1 CHEMBL3667216 IC50 22.0 nM
NCC1(c2ccc(-c3c(O)cc(Cl)c4[nH]c(=O)c5sccc5c34)cc2)CC1 CHEMBL3672268 IC50 22.0 nM
Cc1cc(O)c(-c2ccc(C(C)(C)CN)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672343 IC50 22.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)CN)c(F)c1 CHEMBL3672366 IC50 22.0 nM
COc1cc(C)c2[nH]c(=O)c3sc(F)cc3c2c1-c1ccc([C@@H](C)CN)cc1 CHEMBL3672379 IC50 22.0 nM
CC(c1ccc(-c2c(O)cc(F)c3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3667231 IC50 23.0 nM
CC(=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667253 IC50 23.0 nM
O=c1[nH]c2ccc(O)c(-c3ccc(S(=O)(=O)NCCCl)cc3)c2c2ccsc12 CHEMBL3672231 IC50 23.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(CN)C2CCCC2)cc1 CHEMBL3672324 IC50 23.0 nM
CNCCc1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672332 IC50 25.0 nM
COc1cc(F)c2[nH]c(=O)c3sccc3c2c1-c1ccc(CN)cc1 CHEMBL3667237 IC50 26.0 nM
CC[C@@H](N)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672288 IC50 26.0 nM
CN[C@H](C)c1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672279 IC50 30.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1/C=C/CN1CCC(N)CC1 CHEMBL3667213 IC50 31.0 nM
NCc1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667244 IC50 31.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(S(=O)(=O)NCCF)cc1 CHEMBL3672232 IC50 31.0 nM
CC(CBr)NS(=O)(=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672254 IC50 31.0 nM
N#CC1(c2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2)CC1 CHEMBL3672247 IC50 32.0 nM
CNC[C@H](C)c1ccc(-c2c(OC)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672354 IC50 32.0 nM
Cc1cc(O)c(-c2ccc([C@@H](C)CN(C)C)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672369 IC50 32.0 nM
CC(=O)Oc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)N)cc1 CHEMBL3672264 IC50 33.0 nM
C[C@@H](N)c1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672272 IC50 33.0 nM
C[C@H](CN)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672300 IC50 33.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc(CCN)c(Cl)c1 CHEMBL3672335 IC50 33.0 nM
CNC[C@H](C)c1ccc(-c2c(OC)cc(C)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672365 IC50 33.0 nM
CC(c1ccc(-c2c(O)c(F)c(F)c3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3672239 IC50 34.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc(C2(CN)CCC2)cc1 CHEMBL3672353 IC50 35.0 nM
Cc1cc(O)c(-c2ccc(CC(C)N)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672325 IC50 37.0 nM
COc1cc(C)c2[nH]c(=O)c3sc(C)cc3c2c1-c1ccc([C@@H](C)CN)cc1 CHEMBL3672372 IC50 38.0 nM
Cc1cc(O)c(-c2ccc(C(C)(C)CN)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672321 IC50 39.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)CN)c(F)c1 CHEMBL3672340 IC50 40.0 nM
CC[C@@H](CN)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672374 IC50 40.0 nM
CC(N)Cc1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672265 IC50 41.0 nM
C[C@H](c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1)N(C)C CHEMBL3672273 IC50 42.0 nM
Cc1cc(O)c(-c2ccc(C3(CN(C)C)CCC3)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672378 IC50 42.0 nM
CNCC(C)c1ccc(-c2c(OC)cc(C)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672347 IC50 43.0 nM
C[C@@H](CN(C)C)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672373 IC50 43.0 nM
CN(C)S(=O)(=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667257 IC50 45.0 nM
NCCc1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672281 IC50 45.0 nM
CNCCc1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1F CHEMBL3672326 IC50 45.0 nM
Cc1cc(O)c(-c2ccc(C(C)CN(C)C)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672306 IC50 46.0 nM
CCN(CC)CCNCCCOc1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3667212 IC50 47.0 nM
CC(N)c1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672251 IC50 47.0 nM
CC[C@@H](N)c1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672284 IC50 47.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc(C(CN)C(C)C)c(F)c1 CHEMBL3672345 IC50 47.0 nM
CNCC(c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1)C(C)C CHEMBL3672346 IC50 50.0 nM
NCC1(c2ccc(-c3c(O)cc(Br)c4[nH]c(=O)c5sccc5c34)cc2)CC1 CHEMBL3672385 IC50 51.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc([C@H](C)CN)c(F)c1 CHEMBL3672361 IC50 54.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc(C2(CN)CC2)cc1 CHEMBL3672328 IC50 55.0 nM
CNCCc1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672377 IC50 55.0 nM
COc1cc(C)c2[nH]c(=O)c3sccc3c2c1-c1ccc(CCN)c(F)c1 CHEMBL3672314 IC50 57.0 nM
CNCCc1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672293 IC50 58.0 nM
Cc1cc(O)c(-c2ccc([C@H](C)CN(C)C)c(F)c2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672383 IC50 58.0 nM
CNC[C@@H](C)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672313 IC50 60.0 nM
Cc1cc(O)c(-c2ccc(N(C)CCN)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672384 IC50 60.0 nM
COC(=O)c1cccc(-c2cnc3[nH]cc(-c4cncnc4)c3c2)c1 CHEMBL5082392 IC50 62.5 nM
CCC(CN)c1ccc(-c2c(OC)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672342 IC50 63.0 nM
CN[C@H](C)c1ccc(-c2c(OC)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672337 IC50 67.0 nM
COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(S(=O)(=O)NCCCl)cc1 CHEMBL3639711 IC50 70.0 nM
COc1cc(Br)c2[nH]c(=O)c3sccc3c2c1-c1ccc(C2(CN)CC2)cc1 CHEMBL3672382 IC50 70.0 nM
CC(C)(CN)c1ccc(-c2c(O)cc(Br)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672327 IC50 72.0 nM
CC(C)(CN)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672333 IC50 75.0 nM
Cc1cc(O)c(-c2ccc(C3CCCNC3)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672356 IC50 75.0 nM
CC(C)OC(=O)Oc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)N)cc1 CHEMBL3672257 IC50 76.0 nM
CCN(C)C[C@H](C)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3639712 IC50 76.0 nM
N[C@H]1CCN(c2ccc3[nH]c(=O)c4sc(-c5ccc(O)cc5)cc4c3c2)C1 CHEMBL3667201 IC50 78.0 nM
COc1cc(F)c2[nH]c(=O)c3sccc3c2c1-c1ccc(CCN(C)C)cc1 CHEMBL3667230 IC50 82.0 nM
Cc1cc(O)c(-c2ccc(C(C)CS(N)(=O)=O)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672386 IC50 82.0 nM
CN(C)C1CCCN(CCCc2c(O)ccc3[nH]c(=O)c4sccc4c23)C1 CHEMBL3667255 IC50 83.0 nM
CC[C@@H](CNC)c1ccc(-c2c(O)cc(C)c3[nH]c(=O)c4sccc4c23)cc1 CHEMBL3672380 IC50 85.0 nM
COc1cc(Cl)c2[nH]c(=O)c3sccc3c2c1-c1ccc(CCN)c(F)c1 CHEMBL3672316 IC50 87.0 nM
Cc1cc(O)c(-c2ccc(CCC#N)cc2)c2c1[nH]c(=O)c1sccc12 CHEMBL3672320 IC50 92.0 nM
COc1cc(Cl)c2[nH]c(=O)c3sccc3c2c1-c1ccc(C2(CN)CCC2)cc1 CHEMBL3672368 IC50 96.0 nM
COC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL5091645 IC50 123.0 nM
N#Cc1cccc(-c2cnc3[nH]cc(-c4cccnc4)c3c2)c1 CHEMBL5091627 IC50 129.0 nM
COC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)c1 CHEMBL5082440 IC50 140.0 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 150.4 nM
COC(=O)c1cccc(-c2cnc3[nH]cc(-c4cccc(OC)c4)c3c2)c1 CHEMBL5086489 IC50 166.0 nM
COc1cc(-c2cnc(N)c(N3CC[C@@H](C(=O)O)[C@@H](C)[C@H]3C)n2)cc(OC)c1OC CHEMBL1276848 IC50 170.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 170.0 nM
O=S(=O)(N[C@@H](CO)Cc1c[nH]c2ccccc12)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL5201686 IC50 330.0 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 CHEMBL2180604 Kd apparent 365.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 477.0 nM
O=C1/C(=C/c2ccccn2)CNC/C1=C\c1ccccn1 CHEMBL574646 IC50 500.0 nM
Cn1c(=O)c(S(=O)(=O)c2ccc(F)cc2F)cc2cnc(Nc3ccc4[nH]ccc4c3)nc21 CHEMBL3745885 IC50 630.0 nM
c1ccc(Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cc1 CHEMBL4454763 IC50 850.0 nM
O=S(=O)(N[C@H](CO)Cc1c[nH]c2ccccc12)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL5206874 IC50 990.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM