CCn1nnc2c(C)c([C@@H](CC(=O)O)c3ccc4c(c3)CN(C(=O)c3c(C)c(C)cc(C)c3C)CC4)ccc21 CHEMBL4643134 EC50 9.2 nM
COC(=O)[C@H]1C[C@]2(C)[C@H](C(=O)C=C3[C@@]4(C)C=C(C#N)C(=O)C(C)(C)[C@@H]4CC[C@]32C)[C@@H]2CC(C)(C)CC[C@H]21 CHEMBL4776211 EC50 10.0 nM
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3C[C@@H](C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 CHEMBL4450921 EC50 11.0 nM
O=c1n(/C=C/S(=O)(=O)c2ccccc2)nnn1-c1cccnc1 CHEMBL5437928 EC50 20.0 nM
O=S(=O)(/C=C/c1ncccc1Cl)c1ccccc1Cl CHEMBL4793600 EC50 26.0 nM
COC(=O)[C@@]12OC[C@]34[C@H]([C@@H](O)[C@@H]1O)[C@@]1(C)CC(=O)C(O)=C(C)[C@@H]1C[C@H]3OC(=O)[C@H](OC(=O)C=C(C)C)[C@@H]24 CHEMBL459546 IC50 29.19 nM
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3CC(C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 CHEMBL4447060 EC50 30.0 nM
O=S(=O)(/C=C/c1ncccc1Cl)c1ccccc1F CHEMBL4757795 EC50 30.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2ncccc2Cl)c1 CHEMBL5418829 EC50 30.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2ccncc2Cl)c1 CHEMBL5425099 EC50 32.0 nM
COc1ccc(S(=O)(=O)/C=C/c2ncccc2Cl)nc1 CHEMBL5411493 EC50 33.0 nM
COc1cccnc1S(=O)(=O)/C=C/c1ncccc1Cl CHEMBL5413077 EC50 37.0 nM
CCC[C@@H]1CCCCN1C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3[C@H]3C[C@@H]3c3cn(C)nn3)c2)c1 CHEMBL5206387 EC50 43.0 nM
O=S(=O)(/C=C/c1ncccc1Cl)c1cccc(Cl)c1 CHEMBL4783026 EC50 46.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2cccnc2Cl)c1 CHEMBL5402606 EC50 49.0 nM
COc1ccncc1S(=O)(=O)/C=C/c1ncccc1Cl CHEMBL5394925 EC50 51.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2ccccc2Cl)c1 CHEMBL5429249 EC50 58.0 nM
COC(=O)[C@]12CCC(C)(C)C[C@H]1[C@H]1C(=O)C=C3[C@@]4(C)C=C(C#N)C(=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2 CHEMBL1762621 EC50 60.0 nM
CCn1nnc2c(C)c([C@H](c3ccc4c(c3)CN(C(=O)c3c(C)c(C)cc(C)c3C)CC4)[C@H](C)C(=O)O)ccc21 CHEMBL4644995 EC50 60.0 nM
O=S(=O)(/C=C/c1ncccc1Cl)c1ccc(Cl)cc1 CHEMBL4742069 EC50 65.0 nM
Oc1ccccc1-c1nc(-c2ccccc2)no1 CHEMBL1876217 EC100 65.1 nM
Oc1ccccc1-c1nc(-c2ccc(C(F)(F)F)cc2)no1 CHEMBL4859206 EC100 72.0 nM
COc1ncccc1S(=O)(=O)/C=C/c1ncccc1Cl CHEMBL5419884 EC50 75.0 nM
COc1ccccc1OS(=O)(=O)/C=C/c1ccccc1Cl CHEMBL4584457 EC50 76.0 nM
COc1cccnc1S(=O)(=O)/C=C/c1ccccc1Cl CHEMBL5411501 EC50 76.0 nM
COc1cc([C@H](CC(=O)O)c2ccc(C)c(CN3C[C@@H](C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 CHEMBL4578025 EC50 83.0 nM
O=S(=O)(/C=C/c1ncccc1Cl)c1cccc(F)c1 CHEMBL4784396 EC50 84.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ncccc2Cl)n1 CHEMBL5396065 EC50 93.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ncccc2Cl)c1 CHEMBL4585959 EC50 98.0 nM
COc1cccnc1S(=O)(=O)/C=C/c1ncccc1C(F)(F)F CHEMBL5412602 EC50 107.0 nM
CC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O CHEMBL3928693 IC50 115.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2ccccc2C(F)(F)F)c1 CHEMBL5418586 EC50 115.0 nM
CCCC1CCCCN1C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CC3c3cn(C)nn3)c2)c1 CHEMBL5208555 EC50 120.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1ccccc1Cl CHEMBL4764027 EC50 122.0 nM
O=S(=O)(/C=C/c1ccccc1F)c1ncccc1C(F)(F)F CHEMBL4565846 EC50 124.0 nM
COc1ccc(S(=O)(=O)/C=C/c2ccccc2Cl)nc1 CHEMBL5412220 EC50 130.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ccc(Cl)cn2)c1 CHEMBL4575846 EC50 132.0 nM
COc1ccccc1S(=O)(=O)/C=C/c1ncccc1Cl CHEMBL4561432 EC50 142.0 nM
COc1cccnc1S(=O)(=O)/C=C/c1ccccc1C(F)(F)F CHEMBL5430306 EC50 146.0 nM
O=S(=O)(/C=C\c1cccc(Cl)n1)c1ccccc1Cl CHEMBL4745552 EC50 147.0 nM
COc1ccccc1S(=O)(=O)/C=C/c1c(Cl)ncnc1Cl CHEMBL4534364 EC50 148.0 nM
COc1cccc(OS(=O)(=O)/C=C/c2ccccc2Cl)c1 CHEMBL4444710 EC50 165.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2ncccc2C(F)(F)F)c1 CHEMBL5408542 EC50 174.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1ccccc1F CHEMBL4747250 EC50 176.0 nM
COc1ccccc1S(=O)(=O)/C=C/c1ccc(Cl)nc1Cl CHEMBL4590075 EC50 178.0 nM
COc1ncccc1S(=O)(=O)/C=C/c1ccccc1Cl CHEMBL5399310 EC50 189.0 nM
O=S(=O)(/C=C/c1cccnc1Cl)c1ccccc1Cl CHEMBL4758317 EC50 192.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ncccc2C(F)(F)F)n1 CHEMBL5437238 EC50 194.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1cccc(Cl)c1 CHEMBL4760792 EC50 198.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1ncccc1C(F)(F)F CHEMBL4467057 EC50 202.0 nM
O=S(=O)(/C=C/c1cccnc1Cl)c1cccc(Cl)c1 CHEMBL4789760 EC50 213.0 nM
COc1ncccc1S(=O)(=O)/C=C/c1ncccc1C(F)(F)F CHEMBL5434521 EC50 214.0 nM
O=S(=O)(/C=C/c1cccnc1Cl)c1ccccc1F CHEMBL4759579 EC50 217.0 nM
O=S(=O)(/C=C/c1ncccc1Cl)c1ccc(F)cc1 CHEMBL4741252 EC50 231.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ccccc2Cl)n1 CHEMBL5423361 EC50 231.0 nM
COc1ccc(OS(=O)(=O)/C=C/c2ccccc2Cl)cc1 CHEMBL4468759 EC50 237.0 nM
COc1ccc(S(=O)(=O)/C=C/c2ccccc2C(F)(F)F)nc1 CHEMBL5405761 EC50 245.0 nM
O=S(=O)(/C=C/c1ncccc1Cl)c1ccc(OCCCN2CCOCC2)cc1 CHEMBL4473995 EC50 246.0 nM
COc1ccncc1S(=O)(=O)/C=C/c1ccccc1C(F)(F)F CHEMBL5437229 EC50 248.0 nM
O=S(=O)(/C=C\c1ncccc1F)c1cccc(Cl)c1 CHEMBL4755395 EC50 252.0 nM
CCn1nnc2c(C)c([C@@H](CC(=O)O)c3cc(C)c4c(c3)CN(C(=O)c3ccccc3)CC4)ccc21 CHEMBL4635041 EC50 270.0 nM
COc1ccc(S(=O)(=O)/C=C/c2ncccc2C(F)(F)F)nc1 CHEMBL5395125 EC50 275.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1ccc(Cl)cc1 CHEMBL4742701 EC50 286.0 nM
O=S(=O)(/C=C\c1ncccc1Cl)c1cccc(Cl)c1 CHEMBL4746979 EC50 290.0 nM
Fc1cccc(/C=C/c2cc(F)ccc2F)c1 CHEMBL3935576 EC50 300.0 nM
Cc1ccc(S(=O)(=O)/C=C/n2nnn(C)c2=O)cc1 CHEMBL5408914 EC50 300.0 nM
O=S(=O)(/C=C/c1cccnc1Cl)c1ccc(Cl)cc1 CHEMBL4742995 EC50 305.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ccccc2C(F)(F)F)n1 CHEMBL5417522 EC50 316.0 nM
CN1CCN(C(=O)COc2ccc(S(=O)(=O)/C=C/c3ncccc3Cl)cc2)CC1 CHEMBL4578412 EC50 327.0 nM
O=S(=O)(/C=C/c1cccnc1Cl)c1cccc(F)c1 CHEMBL4743140 EC50 328.0 nM
CCn1nnc2c(C)c([C@H](c3ccc4c(c3)CN(C(=O)c3c(C)c(C)cc(C)c3C)CC4)[C@@H](C)C(=O)O)ccc21 CHEMBL4634531 EC50 330.0 nM
O=S(=O)(/C=C/c1cccnc1Cl)c1ccc(F)cc1 CHEMBL4795499 EC50 339.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1ccc(OCCCN2CCOCC2)cc1 CHEMBL4465428 EC50 346.0 nM
COc1ccc(S(=O)(=O)/C=C/c2ncccc2Cl)cc1 CHEMBL4455181 EC50 347.0 nM
COc1cccc(S(=O)(=O)/C=C/c2cccnc2Cl)c1 CHEMBL4565692 EC50 348.0 nM
O=S(=O)(/C=C/c1ccccc1F)c1ccncc1 CHEMBL4563234 EC50 350.0 nM
Cn1nnn(/C=C/S(=O)(=O)c2ccccc2)c1=O CHEMBL5440555 EC50 360.0 nM
O=S(=O)(/C=C\c1cccnc1Cl)c1ccccc1Cl CHEMBL4776866 EC50 384.0 nM
O=C(O)CCN[C@H]1CS(=O)(=O)C[C@@H]1S(=O)(=O)c1ccc(Cl)c(Cl)c1 CHEMBL5274677 EC50 400.0 nM
COC(=O)CCN[C@H]1CS(=O)(=O)C[C@@H]1S(=O)(=O)c1ccc(Cl)c(Cl)c1 CHEMBL5267890 EC50 400.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2ccnc(Cl)c2)c1 CHEMBL5397794 EC50 400.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ncccc2F)c1 CHEMBL4552886 EC50 444.0 nM
Fc1cccc(/C=C/c2ccc(F)cc2F)c1 CHEMBL3962219 EC50 450.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1cccc(F)c1 CHEMBL4778440 EC50 474.0 nM
O=S(=O)(/C=C\c1ncccc1F)c1ccccc1F CHEMBL4741491 EC50 482.0 nM
O=S(=O)(/C=C/c1ccncc1)c1cccc(Cl)c1 CHEMBL4763914 EC50 528.0 nM
COc1ccccc1S(=O)(=O)/C=C/c1ccccc1Cl CHEMBL3125749 EC50 530.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1ccc(F)cc1 CHEMBL4778867 EC50 542.0 nM
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3CCN(C)c4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 CHEMBL4540327 EC50 570.0 nM
C[S+]([O-])CCCCN=C=S CHEMBL48802 EC50 580.0 nM
C[S@@+]([O-])CCCCN=C=S CHEMBL128136 EC50 580.0 nM
O=S(=O)(/C=C\c1ncccc1F)c1ccccc1Cl CHEMBL4756295 EC50 583.0 nM
O=S(=O)(/C=C/c1ccccn1)c1ccccc1Cl CHEMBL4784660 EC50 618.0 nM
COc1cccnc1C(=O)/C=C/c1ccccc1C(F)(F)F CHEMBL3605322 EC50 625.0 nM
Fc1ccc(/C=C/c2cccc(F)c2)cc1 CHEMBL2261005 EC50 650.0 nM
COc1cccc(S(=O)(=O)/C=C/c2ccncc2)c1 CHEMBL4475115 EC50 655.0 nM
CCn1nnc2c(C)c([C@@H](CC(=O)O)c3ccc4c(c3)CN(C(=O)c3ccccc3)CC4)ccc21 CHEMBL4642419 EC50 690.0 nM
COc1ccccc1OS(=O)(=O)/C=C/c1cccc(Cl)c1 CHEMBL4526321 EC50 698.0 nM
Fc1ccccc1/C=C/c1ccccc1 CHEMBL3960954 EC50 700.0 nM
COc1ncccc1S(=O)(=O)/C=C/c1ccccc1C(F)(F)F CHEMBL5394547 EC50 749.0 nM
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3C[C@H](C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 CHEMBL4457466 EC50 760.0 nM
O=S(=O)(/C=C/c1ccncc1)c1ccccc1F CHEMBL4799090 EC50 760.0 nM
O=S(=O)(/C=C/c1ccncc1)c1ccccc1Cl CHEMBL4743181 EC50 781.0 nM
COc1cccc(S(=O)(=O)/C=C/c2cccc(Cl)n2)c1 CHEMBL4463072 EC50 786.0 nM
Cc1ccc(/C=C/c2cccc(F)c2)cc1 CHEMBL3973512 EC50 800.0 nM
COc1ccc(OC)c(/C=C/c2ccc(OC)cc2OC)c1 CHEMBL3220144 EC50 800.0 nM
COc1cccnc1S(=O)(=O)/C=C/c1ccccc1F CHEMBL5400374 EC50 801.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2cccc(Cl)c2)c1 CHEMBL5422343 EC50 824.0 nM
COc1ccccc1S(=O)(=O)/C=C/c1cccnc1Cl CHEMBL4439975 EC50 849.0 nM
COc1cc(C(CC(=O)O)c2ccc(C)c(CN(C)S(=O)(=O)c3ccccc3)c2)cc2nnn(C)c12 CHEMBL4554007 EC50 850.0 nM
COc1ccccc1S(=O)(=O)/C=C/c1ncccc1F CHEMBL4457010 EC50 877.0 nM
O=S(=O)(/C=C/c1cccc(Cl)n1)c1ccccc1F CHEMBL4797653 EC50 898.0 nM
COc1cc(/C=C/C(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O CHEMBL128729 EC50 900.0 nM
Fc1ccc(/C=C/c2ccc(F)cc2F)cc1 CHEMBL2261007 EC50 900.0 nM
NCCCCN[C@H]1CS(=O)(=O)C[C@@H]1S(=O)(=O)c1ccc(Cl)c(Cl)c1 CHEMBL5277690 EC50 900.0 nM
NCCCCCCN[C@H]1CS(=O)(=O)C[C@@H]1S(=O)(=O)c1ccc(Cl)c(Cl)c1 CHEMBL5281401 EC50 900.0 nM
NC(=O)CCN[C@H]1CS(=O)(=O)C[C@@H]1S(=O)(=O)c1ccc(Cl)c(Cl)c1 CHEMBL5277837 EC50 900.0 nM
COC(=O)/C=C/n1nnn(-c2cccnc2)c1=O CHEMBL5433953 EC50 900.0 nM
O=S(=O)(/C=C/c1ncccc1F)c1cccc(OCCCN2CCOCC2)c1 CHEMBL4541592 EC50 908.0 nM
COc1ccnc(S(=O)(=O)/C=C/c2ccc(Cl)nc2)c1 CHEMBL5407290 EC50 914.0 nM
COc1cccc(OS(=O)(=O)/C=C/c2cccc(Cl)c2)c1 CHEMBL4461002 EC50 943.0 nM
COc1ccc(OS(=O)(=O)/C=C/c2cccc(Cl)c2)cc1 CHEMBL4438169 EC50 948.0 nM
O=S(=O)(/C=C/c1ccncc1)c1cccc(F)c1 CHEMBL4745297 EC50 950.0 nM
COc1ccc(S(=O)(=O)/C=C/c2cccnc2Cl)cc1 CHEMBL4459567 EC50 955.0 nM
O=S(=O)(/C=C\c1ccc(Cl)nc1)c1cccc(F)c1 CHEMBL4795033 EC50 965.0 nM
Fc1cccc(/C=C/c2cccc(F)c2)c1 CHEMBL3891875 EC50 1000.0 nM