CC1CN=C(Nc2ccc(Cl)c3c2CCC3)C1 CHEMBL3546401 Ki 0.22 nM
c1ccc2cc(C3=NCCN3)ccc2c1 CHEMBL266155 Log Ki 0.631 nM
Cc1ccccc1OCC1=NCCN1 CHEMBL14097 Log Ki 0.7943 nM
c1ccc(OCC2=NCCN2)cc1 CHEMBL14640 Log Ki 1.0 nM
C[C@@H](Cc1ccccc1)C1=NCCN1 CHEMBL2092861 Log Ki 1.072 nM
C=CCc1ccccc1OCC1=NCCN1 CHEMBL14107 Log Ki 1.259 nM
c1ccc2nc(C3=NCCN3)ccc2c1 CHEMBL13698 Log Ki 1.585 nM
c1ccc2oc(C3=NCCN3)cc2c1 CHEMBL404505 Log Ki 1.585 nM
c1ccc2c(C3=NCCN3)cccc2c1 CHEMBL418536 Log Ki 1.585 nM
Cc1ccc2c(c1)N(C)CC(C1=NCCN1)O2 CHEMBL13987 Ki 1.99 nM
CC(C)c1ccccc1OCC1=NCCN1 CHEMBL14012 Log Ki 1.995 nM
c1ccc2c(OCC3=NCCN3)cccc2c1 CHEMBL279200 Log Ki 1.995 nM
C(=C/c1ccccc1)\C1=NCCN1 CHEMBL275970 Log Ki 1.995 nM
c1ccc(CCC2=NCCN2)cc1 CHEMBL14210 Log Ki 2.512 nM
CCc1ccccc1OCC1=NCCN1 CHEMBL13887 Log Ki 2.512 nM
c1ccc2c(c1)ccc1oc(C3=NCCN3)cc12 CHEMBL266861 Log Ki 2.512 nM
c1cc2cc(C3=NCCN3)ccc2[nH]1 CHEMBL13343 Log Ki 2.512 nM
Cc1ccc(NC2=NCC(C)C2)c2c1CCC2 CHEMBL3546402 Ki 2.8 nM
CC1CCC(Nc2ccc(Cl)c3c2CCC3)=N1 CHEMBL3546398 Ki 2.8 nM
Cc1ccc(C2=NCCN2)cc1F CHEMBL267801 Log Ki 3.162 nM
c1ccc2ncc(C3=NCCN3)cc2c1 CHEMBL13631 Log Ki 3.162 nM
c1cc2c3c(c1)ccn3CC(C1=NCCN1)O2 CHEMBL60186 Ki 3.5 nM
COc1nc(C)nc(Cl)c1NC1=NCCN1 CHEMBL19236 pIC50 3.548 nM
c1ccc2cc(OCC3=NCCN3)ccc2c1 CHEMBL13892 Log Ki 3.981 nM
CSc1ccc(C2=NCCN2)cc1 CHEMBL276276 Log Ki 3.981 nM
C1=C(C2=NCCN2)COc2ccccc21 CHEMBL14203 Log Ki 3.981 nM
c1ccc(C2CC2)c(OCC2=NCCN2)c1 CHEMBL13852 Log Ki 3.981 nM
CN1CC(C2=NCCN2)Oc2ccc(F)cc21 CHEMBL14242 Ki 4.7 nM
Clc1cc(I)cc(Cl)c1N=C1NCCN1 CHEMBL360803 pKi 4.797 nM
Cc1cccc(C2=NCCN2)c1 CHEMBL276487 Log Ki 5.012 nM
COc1ccc(C2=NCCN2)cc1 CHEMBL13633 Log Ki 5.012 nM
Cc1c(C#N)cccc1C1=NCCN1 CHEMBL14528 Log Ki 5.012 nM
c1cc2c(cc1C1=NCCN1)OCO2 CHEMBL268945 Log Ki 5.012 nM
CC(Cc1ccccc1)C1=NCCN1 CHEMBL71429 Log Ki 5.012 nM
CC1CC/C(=N\c2cc(N=[N+]=N)c(I)cc2Cl)N1 CHEMBL468161 pKi 6.026 nM
Cc1cc(C(C)(C)C)c(O)c(C)c1CC1=NCCN1 CHEMBL762 pKi 6.194 nM
Cc1ccc(F)c(C2=NCCN2)c1 CHEMBL268734 Log Ki 6.31 nM
CCCc1ccccc1OCC1=NCCN1 CHEMBL13917 Log Ki 6.31 nM
COC(=O)c1ccc2c(c1)N(C)CC(C1=NCCN1)O2 CHEMBL62107 Ki 7.0 nM
c1ccc2c(c1)OCC(C1=NCCN1)O2 CHEMBL10316 Log Ki 7.943 nM
CN1CC(C2=NCCN2)Oc2ccccc21 CHEMBL14028 Log Ki 7.943 nM
Cc1ccc(C2=NCCN2)cc1 CHEMBL269197 Log Ki 7.943 nM
Cc1c(Cl)cccc1NC1=NCC(C)C1 CHEMBL3547056 Ki 8.1 nM
CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21 CHEMBL4536304 pIC50 8.128 nM
Clc1cccc(Cl)c1NC1=NCCN1 CHEMBL134 Ki 8.9 nM
C1=C(C2=NCCN2)CCc2ccccc21 CHEMBL266386 Log Ki 10.0 nM
Cc1ccccc1C1=NCCN1 CHEMBL278221 Log Ki 10.0 nM
c1cc2c3c(c1)OC(C1=NCCN1)CN3CCC2 CHEMBL274784 Log Ki 10.0 nM
COc1ccc2cc(C3=NCCN3)ccc2c1 CHEMBL13824 Log Ki 10.0 nM
C/C(=C\c1ccccc1)C1=NCCN1 CHEMBL14174 Log Ki 10.0 nM
c1ccc(-c2ccc(C3=NCCN3)cc2)cc1 CHEMBL13809 Log Ki 10.0 nM
c1ccc2c(c1)COC(C1=NCCN1)O2 CHEMBL273408 Log Ki 10.0 nM
CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CCc3ccccc3)C(=O)C21 CHEMBL4434967 pIC50 10.47 nM
Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 CHEMBL597 pKi 11.4 nM
c1ccc([C@H]2C[C@@H]2C2=NCCN2)cc1 CHEMBL94022 Log Ki 11.75 nM
COc1ccc2c3c([nH]c2c1)CNCC3 CHEMBL6310 Ki 12.0 nM
c1ccc2c(c1)CC(C1=NCCN1)CO2 CHEMBL13743 Log Ki 15.85 nM
COc1cccc(C2=NCCN2)c1 CHEMBL266863 Log Ki 15.85 nM
CCOCc1ccc2c(c1)N(C)CC(C1=NCCN1)O2 CHEMBL300388 Ki 17.0 nM
c1ccc(C2CC2C2=NCCN2)cc1 CHEMBL67706 Log Ki 17.38 nM
CC1CCC(Nc2cccc3c2CCC3)=N1 CHEMBL3546379 Ki 19.0 nM
N=C(N)NC(=O)Cc1c(Cl)cccc1Cl CHEMBL862 pKi 19.01 nM
COc1ccc2c(c1)[nH]c1c(C)nccc12 CHEMBL269538 Ki 22.0 nM
Cc1cccc2c1OC(C1=NCCN1)CN2C CHEMBL13958 Ki 22.7 nM
c1ccc([C@@H]2C[C@H]2C2=NCCN2)cc1 CHEMBL93845 Log Ki 22.91 nM
c1ccc(-c2cccc(C3=NCCN3)c2)cc1 CHEMBL13886 Log Ki 25.12 nM
Fc1cccc(C2=NCCN2)c1 CHEMBL13715 Log Ki 25.12 nM
Clc1ccc2nsnc2c1NC1=NCCN1 CHEMBL1079 Ki 28.3 nM
CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C3CCCCC3)C(=O)C21 CHEMBL4535472 pIC50 28.84 nM
CCc1cccc(C2=NCCN2)c1 CHEMBL14267 Log Ki 31.62 nM
c1ccc(NCC2=NCCN2)cc1 CHEMBL13881 Log Ki 31.62 nM
c1cc2c3c(c1)OC(C1=NCCN1)CN3CC2 CHEMBL13955 Log Ki 31.62 nM
N=C(N)N/N=C/c1c(Cl)cccc1Cl CHEMBL420 pKi 34.67 nM
CCC(=O)N(CCCCCCCCNC(=N)N)C1CCN(CCc2ccccc2)CC1 CHEMBL146997 Ki 37.0 nM
C1CCCC(C2=NCCN2)CC1 CHEMBL14235 Log Ki 39.81 nM
Cc1ccsc1C1=NCCN1 CHEMBL14422 Log Ki 39.81 nM
c1ccc(C2=NCCN2)cc1 CHEMBL274548 Log Ki 39.81 nM
c1ccc(Oc2ccc(C3=NCCN3)cc2)cc1 CHEMBL13689 Log Ki 39.81 nM
CC(C)C1C2CCC(C2)C1N CHEMBL430112 Ki 42.0 nM
Cc1cc2c(cc1C)N(C)CC(C1=NCCN1)O2 CHEMBL60031 Ki 43.0 nM
CC1=NCCc2c1[nH]c1ccccc21 CHEMBL295234 Ki 46.0 nM
Cc1ccc2c(c1)OC(C1=NCCN1)CN2C CHEMBL276035 Ki 47.0 nM
CCC(C)c1ccccc1OCC1=NCCN1 CHEMBL13639 Log Ki 50.12 nM
c1ccc2c(c1)OC(C1=NCCN1)CS2 CHEMBL14015 Log Ki 50.12 nM
c1ccc(SCC2=NCCN2)cc1 CHEMBL13844 Log Ki 50.12 nM
FC(F)(F)c1ccc(C2=NCCN2)cc1 CHEMBL13854 Log Ki 50.12 nM
c1ccc2c(c1)NCC(C1=NCCN1)O2 CHEMBL13918 Log Ki 50.12 nM
CCC1(C2=NCCN2)Cc2ccccc2O1 CHEMBL57895 pKi 52.36 nM
C1COC(NC(C2CC2)C2CC2)=N1 CHEMBL289480 pKi 59.16 nM
CCCc1ccc(C2=NCCN2)cc1 CHEMBL275118 Log Ki 63.1 nM
COc1ccc2c(c1)N(C)CC(C1=NCCN1)O2 CHEMBL274315 Log Ki 63.1 nM
c1ccc2c(c1)cc(C1=NCCN1)c1ccccc12 CHEMBL269631 Log Ki 63.1 nM
CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C21 CHEMBL4590209 pIC50 64.57 nM
CC(C)c1ccc(C2=NCCN2)cc1 CHEMBL13569 Log Ki 79.43 nM
FC(F)(F)Oc1ccc(C2=NCCN2)cc1 CHEMBL275502 Log Ki 79.43 nM
Fc1cc(F)cc(C2=NCCN2)c1 CHEMBL277570 Log Ki 79.43 nM
c1ccc2c(c1)OC(C1=NCCN1)O2 CHEMBL13620 Log Ki 79.43 nM
CC(C)Oc1ccccc1OCC1=NCCN1 CHEMBL14226 Log Ki 79.43 nM
CCc1ccc(C2=NCCN2)cc1 CHEMBL13729 Log Ki 79.43 nM
CN1CC(C2=NCCN2)Oc2cc3ccccc3cc21 CHEMBL61689 Ki 93.0 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933288 IC50 97.0 nM
Fc1ccccc1C1=NCCN1 CHEMBL13579 Log Ki 100.0 nM
Cc1ccc(C2=NCC(C)N2)cc1 CHEMBL13742 Log Ki 100.0 nM
CN1CC(C2=NCCN2)Oc2ccc(CO)cc21 CHEMBL58187 Ki 100.0 nM
CC1CCC(Nc2ccccc2Cl)=N1 CHEMBL2058634 Ki 120.0 nM
c1ccc2c(CC3=NCCN3)cccc2c1 CHEMBL761 Ki 121.6 nM
CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 CHEMBL128168 Log Ki 125.89 nM
CN1CC(C2=NCCN2)Oc2ccc(Cl)cc21 CHEMBL13810 Ki 140.0 nM
CCCCc1ccc(C2=NCCN2)cc1 CHEMBL13896 Log Ki 158.49 nM
CCCN1CC(C2=NCCN2)Oc2ccccc21 CHEMBL13940 Log Ki 158.49 nM
Cc1cccc(C2=NCC(C)N2)c1 CHEMBL275774 Log Ki 158.49 nM
Fc1ccc(C2=NCCN2)cc1Cl CHEMBL13879 Log Ki 158.49 nM
N=C(N)C1COc2ccccc2O1 CHEMBL274889 Log Ki 158.49 nM
CCC1CCC(NC(C2CC2)C2CC2)=N1 CHEMBL40399 Log Ki 169.82 nM
c1ccc2c3c([nH]c2c1)CNCC3 CHEMBL269236 Ki 180.0 nM
CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21 CHEMBL4482861 pIC50 181.97 nM
CC(C)(C)c1ccccc1OCC1=NCCN1 CHEMBL14135 Log Ki 199.53 nM
c1ccc(Cc2ccccc2OCC2=NCCN2)cc1 CHEMBL13925 Log Ki 199.53 nM
Cc1ccccc1OC(C)C1=NCCN1 CHEMBL14168 Log Ki 199.53 nM
Clc1cccc2c1CN(NC1=NCCN1)C2 CHEMBL1162356 pKi 231.74 nM
Cc1ccc(-c2ncc[nH]2)cc1 CHEMBL275403 Log Ki 251.19 nM
CC(C)(C)c1cc(C2=NCCN2)cc(C(C)(C)C)c1O CHEMBL280467 Log Ki 251.19 nM
CC(Oc1ccccc1)C1=NCCN1 CHEMBL273485 Log Ki 309.03 nM
c1ccc(-c2ccccc2OCC2=NCCN2)cc1 CHEMBL13789 Log Ki 316.23 nM
c1ccc([C@@H]2C[C@@H]2C2=NCCN2)cc1 CHEMBL2367778 Log Ki 331.13 nM
N=C(N)C1OCc2ccccc2O1 CHEMBL13845 Log Ki 398.11 nM
c1csc(C2=NCCN2)c1 CHEMBL279394 Log Ki 398.11 nM
Cc1cccc2c1N(C)CC(C1=NCCN1)O2 CHEMBL14110 Ki 470.0 nM
CC(C)(C)c1ccc(C2=NCCN2)cc1 CHEMBL276868 Log Ki 501.19 nM
C1CN=C(NC(C2CC2)C2CC2)C1 CHEMBL288951 Log Ki 512.86 nM
CC1CC(NC(C2CC2)C2CC2)=NC1C CHEMBL288139 Log Ki 537.03 nM
COc1cc(=O)n2c3c(cccc13)OC(C1=NCCN1)C2 CHEMBL13858 Ki 560.0 nM
C[C@H](CC1=NCCN1)c1ccccc1 CHEMBL1907831 Log Ki 588.84 nM
CN1CC(C2=NCCN2)Oc2c1ccc1ccccc21 CHEMBL13591 Ki 621.0 nM
c1ccc(C2=NCCCN2)cc1 CHEMBL13670 Log Ki 630.96 nM
c1ccc2c3c(ccc2c1)OC(C1=NCCN1)C3 CHEMBL266835 Log Ki 630.96 nM
c1ccc(C2=NCCN2)nc1 CHEMBL13862 Log Ki 630.96 nM
c1cc2c3c(c1)OC(C1=NCCN1)CN3CCCC2 CHEMBL418716 Log Ki 630.96 nM
CC1CN=C(NC(C2CC2)C2CC2)C1 CHEMBL442156 Log Ki 645.65 nM
CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C)C(=O)C21 CHEMBL4459090 pIC50 645.65 nM
CN1CC(C2=NCCN2)Oc2cc3c(cc21)CCCC3 CHEMBL267074 Ki 690.0 nM
c1ccc([C@H]2C[C@H]2C2=NCCN2)cc1 CHEMBL2367779 Log Ki 724.44 nM
c1ccc2c(C3=NCCN3)c3ccccc3cc2c1 CHEMBL280022 Log Ki 1000.0 nM
Cc1ccc2c3c1CCCN3CC(C1=NCCN1)O2 CHEMBL13793 Log Ki 1000.0 nM