Cc1cc(NC2CCCN(C3CCC3)C2)nnc1-c1ccc2sccc2c1O CHEMBL5419955 IC50 0.07 nM
CC(C)OC(=O)[C@@H](Cn1cc(C#N)cn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5408007 IC50 0.15 nM
CC(C)c1nn(CC(=O)N[C@@H]2CCCN(C3CCC3)C2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5429355 IC50 0.3 nM
CC(C)OC(=O)[C@@H](Cc1ncccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5409389 IC50 0.32 nM
Cc1cc(N[C@@H]2CCCN(C)C2)nnc1-c1ccc(C2CC2)cc1O CHEMBL5435222 IC50 0.38 nM
CCN1CCC[C@@H](Nc2nc3nc(-c4c(C)cc(Cl)cc4O)ccc3o2)C1 CHEMBL5422139 IC50 0.4 nM
Cc1cc(N[C@@H]2CCCN(C)C2)nnc1-c1ccc(C(F)(F)F)cc1O CHEMBL5426651 IC50 0.4 nM
CN1CCC[C@@H](Nc2cc(C(F)(F)F)c(-c3ccc(C(F)(F)F)cc3O)nn2)C1 CHEMBL5414596 IC50 0.4 nM
Cc1cc(Cl)cc(O)c1-c1ccc2oc(N3CC[C@H]4CCN(C)C[C@H]43)nc2n1 CHEMBL5408740 IC50 0.5 nM
CCN1CCC[C@H](Nc2nc3nc(-c4c(C)cc(Cl)cc4O)ccc3o2)C1 CHEMBL5425624 IC50 0.5 nM
Cc1nc(NC(C)c2cccc(O)c2)nnc1-c1ccc(C(F)(F)F)cc1O CHEMBL5438834 IC50 0.5 nM
CC(C)OC(=O)[C@@H](Cc1cnccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5403928 IC50 0.56 nM
CC(C)OC(=O)[C@@H](Cn1cncn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5423228 IC50 0.58 nM
CCN1CCC[C@H](Nc2nc3nc(-c4c(C)cc(Cl)c(F)c4O)ccc3o2)C1 CHEMBL5395560 IC50 0.6 nM
Cc1cc(Cl)cc(O)c1-c1ccc2oc(N[C@H]3CCCN4CCC[C@H]34)nc2n1 CHEMBL5395866 IC50 0.6 nM
COC(=O)CCN1CCC[C@H](Nc2nc3nc(-c4c(C)cc(Cl)cc4O)ccc3o2)C1 CHEMBL5401306 IC50 0.6 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)O[C@H](Cc1ncccn1)C(=O)OC1CCCC1 CHEMBL5427865 IC50 0.62 nM
C[C@]1(O)C[C@@H](Nc2nnc(-c3ccc(C(F)(F)F)cc3O)c3c2COC3)C1 CHEMBL5422375 IC50 0.79 nM
CCN1CCC[C@H](Nc2ccc(-c3c(C)cc(C(F)(F)F)cc3O)nn2)C1 CHEMBL5417431 IC50 0.8 nM
CN1CCC[C@@H](Nc2nnc(-c3ccc(C(F)(F)F)cc3O)c3c2COC3)C1 CHEMBL5431540 IC50 0.843 nM
CCOC(=O)C(Cn1cncn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5411537 IC50 1.0 nM
Cc1ccc(-c2nnc(N[C@@H]3CCCN(C)C3)c3c2C2C=CC3CC2)c(O)c1 CHEMBL5431981 IC50 1.0 nM
CCN1CCC[C@@H](Nc2ccc(-c3c(C)cc(C(F)(F)F)cc3O)nn2)C1 CHEMBL5433380 IC50 1.0 nM
CCN1CCC[C@@H](Nc2ccc(-c3c(C)cc(C#N)cc3O)nn2)C1 CHEMBL5427670 IC50 1.1 nM
Cc1cc(C#N)cc(O)c1-c1ccc(N2CC[C@H]3CCN(C)C[C@H]32)nn1 CHEMBL5416002 IC50 1.2 nM
Cc1cc(N2CCC3CCN(C)CC32)nnc1-c1ccc(C#N)cc1O CHEMBL5397239 IC50 1.8 nM
Cc1cc(N2CC[C@H]3CCN(C)C[C@H]32)nnc1-c1ccc(C#N)cc1O CHEMBL5400478 IC50 1.8 nM
C[C@@]1(CO)Cn2ncc([S@@+](N)([O-])=NC(=O)Nc3c4c(cc5c3CCC5)CCC4)c2O1 CHEMBL5430786 IC50 1.9 nM
CCOC(=O)C(Cn1cc(C#N)cn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5438164 IC50 2.0 nM
Cc1cc(Br)cc(C)c1-n1cc2c(=O)[nH]c(NCC(C)C)nc2n1 CHEMBL5420448 IC50 3.0 nM
Cc1cc(Br)cc(C)c1-n1cc2c(=O)[nH]c(N3C=COCC3)nc2n1 CHEMBL5405701 IC50 3.0 nM
C[C@]1(O)C[C@@H](NC(=O)CN2C[C@@]3(C[C@@H]3F)c3cc(I)ccc3C2=O)C1 CHEMBL5421060 IC50 3.0 nM
C[C@]1(O)C[C@@H](Nc2nnc(-c3ccc(C#N)cc3O)c3c2CCCC3)C1 CHEMBL5423671 IC50 3.0 nM
CCN1CCC[C@@H](Nc2cc(C)c(-c3ccc(C#N)cc3O)nn2)C1 CHEMBL5424780 IC50 3.1 nM
CN(C)C/C=C/S(=O)(=O)NC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5402615 IC50 3.2 nM
Nc1ccc(S(=O)(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)Nc2c3c(cc4c2CCC4)CCC3)cc1 CHEMBL5422387 IC50 3.29 nM
CN(C)C/C=C/S(=O)(=O)NC(=O)Nc1c2c(cc3c1CCC3)C=CC2 CHEMBL5433446 IC50 3.6 nM
Cc1cc(N[C@@H]2CCCN(C)C2)nnc1-c1ccc2ccccc2c1O CHEMBL5404792 IC50 4.34 nM
C[C@H](O)Cn1cc(F)c([S+](N)([O-])=NC(=O)Nc2c3c(nc4c2CCC42CC2)CCC3)n1 CHEMBL5434609 IC50 4.7 nM
CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c1 CHEMBL3183703 IC50 5.0 nM
[2H]C([2H])([2H])C(O)(c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c1)C([2H])([2H])[2H] CHEMBL4204644 IC50 5.0 nM
Cc1ccc(S(=O)(=NC#N)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)cc1F CHEMBL4644835 IC50 5.3 nM
Cc1cc(N[C@@H]2CCCN(C)C2)nnc1-c1ccc(-c2ccc(F)cc2)cc1O CHEMBL5431968 IC50 5.32 nM
Nc1ccc(S(=O)(=O)N2Cc3ccccc3C[C@H]2C(=O)Nc2c3c(cc4c2CCC4)CCC3)cc1 CHEMBL5436366 IC50 5.36 nM
CN[C@@H]1COc2c(S(=O)(=O)NC(=O)Nc3c4c(cc5c3CCC5)CCC4)cnn2C1 CHEMBL5219789 IC50 5.4 nM
CCc1cc(N[C@@H]2CCCN(CC)C2)nnc1-c1ccc(C#N)cc1O CHEMBL5421788 IC50 5.6 nM
CCN1CCC[C@@H](Nc2nnc(-c3ccc(Cl)cc3O)n(C)c2=O)C1 CHEMBL5440051 IC50 5.9 nM
[2H]C1([2H])CCc2cc3c(c(NC(=O)NS(=O)(=O)c4cc(C(C)(C)O)co4)c21)C([2H])([2H])CC3 CHEMBL4209503 IC50 6.0 nM
[2H]C1([2H])CCc2c1cc1c(c2NC(=O)NS(=O)(=O)c2cc(C(C)(C)O)co2)CCC1 CHEMBL4212407 IC50 6.0 nM
N[S+]([O-])(=NC(=O)Nc1c2c(cc3c1CCC3)CCC2)c1cnn2cc(CO)oc12 CHEMBL5422660 IC50 6.1 nM
Cc1ccc(S(=O)(=NC#N)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)cc1 CHEMBL4647321 IC50 6.8 nM
[2H]C1([2H])CCc2c1cc1c(c2NC(=O)NS(=O)(=O)c2cc(C(C)(C)O)co2)CCC1([2H])[2H] CHEMBL4216836 IC50 7.0 nM
CN1C[C@]2(C)CCCN2[C@H](CS(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)C1(C)C CHEMBL5419065 IC50 7.2 nM
CC(C)[C@H](NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)C(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5421905 IC50 7.47 nM
CCOC(=O)C(Cc1ncccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5408252 IC50 8.0 nM
CC(C)c1cc(-c2ccc3c(c2)OC(F)(F)O3)cc(C(C)C)c1CC(=O)NS(=O)(=O)c1sc(C(C)(C)O)nc1CO CHEMBL5414825 IC50 8.0 nM
CC(C)(O)c1ccoc1S(=O)(=O)NC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5399888 IC50 8.1 nM
Cc1c(N[C@@H]2CCCC[C@H]2O)nnc(-c2ccc(C(F)(F)F)cc2O)c1C CHEMBL5421303 IC50 8.4 nM
Cc1ccc(C(F)(F)F)cc1Nc1nc(C(=O)NS(=O)(=O)N2CCCC(S(=O)(=O)N(C)C)CC2)co1 CHEMBL5434150 IC50 8.6 nM
Cc1c(-c2ccc(C(F)(F)F)cc2O)nnc(NC[C@@H](C)O)c1C#N CHEMBL5416723 IC50 9.5 nM
COC(=O)C12CC(NC(=O)Cn3nc(C(C)C)c(OCC(C)C)cc3=O)(C1)C2 CHEMBL5411331 EC50 10.0 nM
Cc1ccc(-c2nnc(N[C@@H]3CCCN(C)C3)c3cscc23)c(O)c1 CHEMBL5437138 IC50 11.0 nM
COc1cc(-c2cccc(C(C)C)c2NC(=O)NS(=O)(=O)c2nc(C(C)(C)O)c[se]2)ccn1 CHEMBL5439444 IC50 11.3 nM
COc1cc(-c2ccc3c(c2NC(=O)NS(=O)(=O)c2nc(C(C)(C)O)c[se]2)CCC3)ccn1 CHEMBL5397618 IC50 11.6 nM
N#CN=S(=O)(NC(=O)Nc1c2c(cc3c1CCC3)CCC2)c1cccc(C#N)c1 CHEMBL4641961 IC50 11.7 nM
COC1CN([C@@H]2COc3c(S(=O)(=O)NC(=O)Nc4c5c(cc6c4CCC6)CCC5)cnn3C2)C1 CHEMBL5218811 IC50 12.0 nM
CC(C)(N)/C=C/[S+]([O-])(=NC#N)NC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5413125 IC50 12.0 nM
S=c1cc(Cc2ccccn2)[nH]c2nc(Nc3c4c(cc5c3CCC5)CCC4)nn12 CHEMBL5196139 IC50 13.0 nM
CN(C)[C@@H]1COc2c(S(=O)(=O)NC(=O)Nc3c4c(cc5c3CCC5)CCC4)cnn2C1 CHEMBL5220779 IC50 13.0 nM
CCOC(=O)C(Cc1cnccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5423220 IC50 14.0 nM
Cc1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)cc1 CHEMBL4642066 IC50 15.0 nM
Cc1cnc(-c2nnc(N[C@@H]3CCCN(C)C3)c3ccccc23)c(O)c1 CHEMBL5405849 IC50 15.0 nM
CCN1CCC[C@H](Nc2nnc(-c3ccc4c(c3O)CCO4)n(C)c2=O)C1 CHEMBL5423352 IC50 16.0 nM
CN(C)c1nn(CC(=O)N[C@H]2C[C@@](C)(O)C2)c(=O)c2cc3sccc3n12 CHEMBL5410447 IC50 17.0 nM
CC(C)c1nn(CC(=O)N[C@H]2C[C@@](C)(O)C2)c(=O)c2cc3ccsc3n12 CHEMBL5411212 IC50 18.4 nM
O=C(CBr)C1CC([N+](=O)[O-])([N+](=O)[O-])C1 CHEMBL5397385 Kd 20.8 nM
N#CN=S(=O)(NC(=O)Nc1c2c(cc3c1CCC3)CCC2)c1ccccc1 CHEMBL4647621 IC50 21.0 nM
Cc1ccc(C(F)(F)F)cc1Nc1nc(C(=O)NS(=O)(=O)N2CCCOCC2)co1 CHEMBL5414296 IC50 21.0 nM
CC(C)c1nn(CC(=O)N[C@H]2CN(C3CCC3)CC[C@H]2O)c(=O)c2cc(C3CC3)nn12 CHEMBL5399242 IC50 21.0 nM
N#CN=S(=O)(NC(=O)Nc1c2c(cc3c1CCC3)CCC2)c1ccccn1 CHEMBL4649141 IC50 23.0 nM
CCOC(=O)C(Cn1cccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5399814 IC50 23.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3c2)c(=O)c2sc(C3CC3)nc12 CHEMBL5400125 IC50 23.0 nM
CCNc1nc2c(C(C)C)nn(CC(=O)Nc3ccc4nncn4c3)c(=O)c2s1 CHEMBL5396495 IC50 23.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1nccs1 CHEMBL4752523 IC50 24.0 nM
CCCOc1ccc(Cl)cc1Cn1cc(-c2ccc(C(=O)OC)cc2)nn1 CHEMBL5400432 Kd 24.0 nM
Cc1ccc(C(F)(F)F)cc1Nc1nc(C(=O)NS(=O)(=O)N(C)C(C)C)co1 CHEMBL5409874 IC50 24.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3c2)c(=O)c2cc3ccccc3n12 CHEMBL5418113 IC50 24.0 nM
CCNc1cc2c(=O)n(CC(=O)Nc3ccc4nncn4c3)nc(C(C)C)n2n1 CHEMBL5423286 IC50 24.0 nM
CC(C)c1nn(CC(=O)Nc2ncc3nc[nH]c3n2)c(=O)c2ccc(C(F)(F)F)cc12 CHEMBL5399146 IC50 24.0 nM
COC(=O)c1ccc(-c2cn(Cc3cc(Cl)ccc3OC)nn2)cc1 CHEMBL5417338 Kd 25.0 nM
CC(C)(O)c1coc(S(=O)(=O)[N-]C(=O)Nc2c3c(cc4c2CCC4)CCC3)c1 CHEMBL4750616 IC50 28.0 nM
CCOC(=O)[C@@H](Cc1cnccn1)NC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL4790034 IC50 30.0 nM
CCOC(=O)[C@@H](Cc1ncccn1)NC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL4780624 IC50 33.0 nM
N#CN=S(=O)(NC(=O)Nc1c2c(cc3c1CCC3)CCC2)c1ccc(C#N)cc1 CHEMBL4643205 IC50 34.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1ccccc1 CHEMBL4640151 IC50 35.0 nM
Cc1ccc(C(F)(F)F)cc1Nc1nc(C(=O)NS(=O)(=O)N2CCCN(S(C)(=O)=O)CC2)co1 CHEMBL5436879 IC50 36.0 nM
N#CN=S(=O)(NC(=O)Nc1c2c(cc3c1CCC3)CCC2)c1cccnc1 CHEMBL4636825 IC50 36.3 nM
CS(C)(=O)=Nc1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)s1 CHEMBL5402007 IC50 36.5 nM
CC(C)c1nn(CC(=O)NC2CCOCC2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5407220 IC50 37.4 nM
CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL5428146 IC50 37.9 nM
Cc1ccc(C(F)(F)F)cc1Nc1nc(C(=O)NS(=O)(=O)N2CCOCC2)co1 CHEMBL5440660 IC50 38.0 nM
CC(C)c1cc(-c2cccc3ccccc23)cc(C(C)C)c1CC(=O)NS(=O)(=O)c1ccc(CN(C)C)cc1 CHEMBL5427989 IC50 40.0 nM
C[C@@H]1CCc2c1nc1c(c2NC(=O)N=[S+]2([O-])NC(=O)c3ccc(C(C)(C)O)cc32)CCC1 CHEMBL5396861 IC50 40.0 nM
N[S+]([O-])(=NC(=O)Nc1c2c(nc(C(F)(F)F)c1C1CC1)CCC2)c1nn(C2CC2)cc1F CHEMBL5409875 IC50 40.3 nM
Cc1ccc(C(F)(F)F)cc1Nc1nc(C(=O)NS(=O)(=O)N2CCCCC2)co1 CHEMBL5431129 IC50 42.0 nM
CC(C)n1nc(CC(=O)Nc2ccc3c(c2)[nH]c(=O)n3C)c(=O)c2ccc(Br)cc21 CHEMBL5440362 IC50 42.0 nM
N[S+]([O-])(=NC(=O)Nc1c2c(nc(C3CC3)c1C1CC1)CCC2)c1nn(C2CC2)cc1F CHEMBL5424110 IC50 42.9 nM
CC(C)n1nc(CC(=O)Nc2ccncn2)c(=O)c2ccc(Br)cc21 CHEMBL5426149 IC50 46.0 nM
CN(C)S(=O)(=O)NC(=O)c1coc(Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL5418666 IC50 48.0 nM
CN(C)c1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c2nsnc12 CHEMBL5207889 IC50 49.0 nM
CN(C)S(=O)(=O)NC(=O)c1cnc(Nc2c3c(cc4c2CCC4)CCC3)o1 CHEMBL5400639 IC50 50.0 nM
CC(C)c1nc2c(C(C)C)nn(CC(=O)Nc3ccc4nncn4c3)c(=O)c2s1 CHEMBL5435937 IC50 50.0 nM
Cc1ccc(C(F)(F)F)cc1Nc1nc(C(=O)NS(=O)(=O)N(C)C)co1 CHEMBL5422590 IC50 53.0 nM
O=C(CN1C(=O)c2ccc(Br)c(F)c2C2(CC2)C1=O)Nc1ncc(Cl)cn1 CHEMBL5418504 IC50 55.0 nM
O=C(Cc1ccc2cc[nH]c2c1)Nc1cccc(O)c1 CHEMBL5180041 IC50 58.0 nM
CN(C)c1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c2nonc12 CHEMBL5184033 IC50 60.0 nM
CSc1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c2nonc12 CHEMBL5188490 IC50 61.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1cnn2c1OCCC2 CHEMBL5219660 IC50 63.0 nM
Cc1ccc(C(C)(C)C)cc1Nc1nc(C(=O)NS(=O)(=O)N(C)C)co1 CHEMBL5424732 IC50 66.0 nM
CC(=O)N1CCCN(S(=O)(=O)NC(=O)c2coc(Nc3cc(C(F)(F)F)ccc3C)n2)CC1 CHEMBL5419479 IC50 66.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)O[C@H](Cc1ncccn1)C(=O)O CHEMBL5423530 IC50 66.0 nM
CCCOc1ccc(Cl)cc1Cn1cc(-c2ccccc2)nn1 CHEMBL5434916 Kd 69.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1cccs1 CHEMBL4758640 IC50 70.0 nM
CC(C)c1cc2c(=O)n(CC(=O)N[C@@H]3CCCN(C4CCC4)C3)nc(C(C)C)n2c1 CHEMBL5418770 IC50 70.0 nM
CC(=O)C1=C(C(Cl)(Cl)Cl)N[B-](c2ccccc2)(c2ccccc2)[O+]=C1N CHEMBL4539790 IC50 74.0 nM
Cc1csc(/C=C/S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL4759516 IC50 76.0 nM
CCS(=O)(=O)Cc1csc(/C=C/S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL4791679 IC50 79.0 nM
O=C(CN1CC2(CC2)c2cc(Br)ccc2C1=O)Nc1ncc(F)cn1 CHEMBL5422571 IC50 81.0 nM
C#CCNS(=O)(=O)c1ccc(CCN(Cc2cc(Cl)ccc2OCCC)C(=O)c2ccc(F)cc2)cc1 CHEMBL5173327 Kd 84.0 nM
CC(C)n1cc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)cn1 CHEMBL5220378 IC50 86.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3c2)c(=O)cc1N1CC2CC2C1 CHEMBL5434541 AC50 90.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3n2)c(=O)cc1N1CC2CC2C1 CHEMBL5423034 EC50 90.0 nM
CCSCc1csc(/C=C/S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL4745667 IC50 93.0 nM
Cc1cc(C(F)(F)F)cc(O)c1-c1ccc(Nc2cccnc2)nn1 CHEMBL5416422 IC50 94.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1ccsc1 CHEMBL4756798 IC50 96.0 nM
CN(C)c1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c2n[se]nc12 CHEMBL5187589 IC50 100.0 nM
CCCNS(=O)(=O)c1ccc2c(c1)CC(N(Cc1cc(Cl)ccc1OCCOC)C(=O)c1cc3ccccc3o1)C2 CHEMBL5413950 Kd 102.7 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1ccc(N2CCOCC2)c2nonc12 CHEMBL5184563 IC50 108.0 nM
Cc1ccc(-c2ccc3c(c2)nc(N)c2nc(CN4CCCC4=O)[nH]c23)cc1 CHEMBL4279629 EC50 110.0 nM
N#CN=S(=O)(NC(=O)Nc1c2c(cc3c1CCC3)CCC2)c1ccncc1 CHEMBL4646271 IC50 110.0 nM
CC(C)c1nn(Cc2nnc(-c3ccc(C(F)(F)F)nc3Cl)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5439097 Kd 110.0 nM
CC(C)OC(=O)[C@H](Cc1ncccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5397039 IC50 120.0 nM
CC(C)c1nn(CC(=O)Nc2ncc(F)cn2)c(=O)c2ccc(Br)cc12 CHEMBL5418118 IC50 121.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1cncs1 CHEMBL4756693 IC50 126.0 nM
S=c1cc(CC2CCCCO2)[nH]c2nc(Nc3c4c(cc5c3CCC5)CCC4)nn12 CHEMBL5185500 IC50 130.0 nM
CC(C)c1nn(CC(=O)Nc2ccncn2)c(=O)c2cc(I)cn12 CHEMBL5415379 IC50 130.0 nM
Cc1ccc(C(C)C)cc1Nc1nc(C(=O)NS(=O)(=O)N(C)C)co1 CHEMBL5408615 IC50 140.0 nM
CC(C)(O)c1csc(/C=C/S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL4742825 IC50 142.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1ccc(Cl)c2nonc12 CHEMBL5184899 IC50 146.0 nM
CC(C)c1nn(CC(=O)N[C@H]2C[C@@](C)(O)C2)c(=O)c2cc3c(n12)CC(C)(C)C3 CHEMBL5432363 IC50 148.9 nM
Cc1ccc2c(c1Nc1nc(C(=O)NS(=O)(=O)N(C)C)co1)CCC2 CHEMBL5399281 IC50 150.0 nM
CC(C)c1nn(Cc2nnc(-c3ccc(F)nc3F)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5420792 IC50 160.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1ccncc1 CHEMBL4778322 IC50 164.0 nM
CC(C)c1ccc(CC(=O)Nc2cccc(O)c2)cc1 CHEMBL5196575 IC50 176.8 nM
CC(C)c1nn(CC(=O)Nc2ncncc2F)c(=O)c2ccc(C(F)(F)F)cc12 CHEMBL5424421 IC50 180.0 nM
CCN(Cc1nc2c(N)nc3cc(-c4cc[nH]n4)ccc3c2n1C)C(=O)OC(C)(C)C CHEMBL4280136 EC50 190.0 nM
CCN(Cc1nc2c(N)nc3cc(-c4ccccc4)ccc3c2[nH]1)C(C)=O CHEMBL4278564 EC50 190.0 nM
CCOC(=O)C(Cn1cccn1)OC(=O)Nc1c(C)cccc1C CHEMBL5432079 IC50 190.0 nM
CC(C)c1cc(C#N)c(F)c(C(C)C)c1CC(=O)NS(=O)(=O)c1sc(C(C)(C)O)nc1CCO CHEMBL5410313 IC50 200.0 nM
CC(C)(O)c1coc(/C=C/S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c1 CHEMBL4792478 IC50 208.0 nM
CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(C(C)O)c1 CHEMBL3781001 IC50 210.0 nM
Cn1cc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)cn1 CHEMBL5218858 IC50 210.0 nM
COc1cc(/C=C/c2ccc(NC(=O)c3ccco3)cc2)c(/C=C/[N+](=O)[O-])c(OC)c1 CHEMBL5202921 Kd 213.0 nM
CCC(=O)N(CC)Cc1nc2c(N)nc3cc(-c4ccn[nH]4)ccc3c2n1CC CHEMBL4276704 EC50 220.0 nM
CCn1c(CN2CCCC2=O)nc2c(N)nc3cc(-c4cccs4)ccc3c21 CHEMBL4284645 EC50 220.0 nM
Nc1nc2cc(-c3ccccc3)ccc2c2[nH]c(CN3CCCC3=O)nc12 CHEMBL4293700 EC50 220.0 nM
Cn1ccc(CNc2nc(N)nc3cc(-c4cc[nH]n4)ccc23)n1 CHEMBL5408556 EC50 230.0 nM
CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2C(O)CC4)CCC3)c1 CHEMBL3904593 IC50 232.0 nM
COc1ccc(CC(=O)Nc2cccc(O)c2)cc1 CHEMBL5186980 IC50 239.2 nM
Nc1nc2cc(-c3cccs3)ccc2c2[nH]c(CN3CCCC3=O)nc12 CHEMBL4277080 EC50 240.0 nM
O=c1cc(Cc2ccccn2)[nH]c2nc(Nc3c4c(cc5c3CCC5)CCC4)nn12 CHEMBL5200838 IC50 240.0 nM
CC[S+]([O-])Cc1csc(/C=C/S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL4778164 IC50 243.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1ccc(N2CC3CCC(C2)O3)c2nonc12 CHEMBL5188246 IC50 243.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1ccc(NC2CC(F)(F)C2)c2nonc12 CHEMBL5183540 IC50 247.0 nM
CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(C(C)(C)O)c1 CHEMBL3781583 IC50 260.0 nM
CC(C)c1ccc2c(c1Nc1nc(C(=O)NS(=O)(=O)N(C)C)co1)CCC2 CHEMBL5397648 IC50 260.0 nM
COc1cc(/C=C/c2ccc(NC(=O)C3CC3)cc2)c(/C=C/[N+](=O)[O-])c(OC)c1 CHEMBL4849582 Kd 263.0 nM
CCOC(=O)C(Cc1ncccn1)OC(=O)Nc1c(C)cccc1C CHEMBL5440114 IC50 270.0 nM
Clc1ccc(-c2nnc(NCC3CCCO3)c3ccccc23)cc1 CHEMBL5426277 IC50 270.0 nM
[2H]C([2H])(c1nnc(-c2ccc(C(F)(F)F)nc2Cl)o1)n1nc(C(C)C)n2c(cc3sc(Cl)cc32)c1=O CHEMBL5410507 IC50 280.0 nM
Cc1cc(C(F)(F)F)cc(O)c1-c1ccc(Nc2cncnc2)nn1 CHEMBL5401365 IC50 281.0 nM
CC(C)c1nn(CC(=O)Nc2ncccn2)c(=O)cc1-c1cc(F)cc(F)c1 CHEMBL5432133 IC50 289.0 nM
Cc1c2c(c(NC(=O)NS(=O)(=O)/C=C/c3nccs3)c3c1CCC3)CCC2 CHEMBL4751187 IC50 294.0 nM
CN1CCN(C(=O)c2cnc(Nc3c4c(cc5c3CCC5)CCC4)o2)S1(=O)=O CHEMBL5394881 IC50 300.0 nM
CCCCCN1C(=O)/C(=C2\SC(=S)N(Cc3ccco3)C2=O)c2cc(Br)ccc21 CHEMBL5423381 IC50 300.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1nc(CO)cs1 CHEMBL4753623 IC50 306.0 nM
Cc1ccc(C2CCC2)cc1Nc1nc(C(=O)NS(=O)(=O)N(C)C)co1 CHEMBL5440833 IC50 310.0 nM
CC(C)c1nn(Cc2nnc(C3CCCC3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5394543 IC50 320.0 nM
Cc1ccc(-c2nnc(Cn3nc(C(C)C)n4c(cc5sc(Cl)cc54)c3=O)o2)c(Cl)n1 CHEMBL5439388 IC50 330.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3c2)c(=O)cc1N1CCCC1 CHEMBL5432357 AC50 330.0 nM
Cn1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL5220708 IC50 340.0 nM
CN(C)C(=O)c1csc(/C=C/S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL4758006 IC50 344.0 nM
CC(C)c1nn(Cc2nnc(-c3cnccc3C(F)(F)F)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5439486 IC50 360.0 nM
Clc1ccc(-c2nnc(NCC3CCCO3)c3cnccc23)cc1 CHEMBL5405032 IC50 360.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1cscn1 CHEMBL4795321 IC50 369.0 nM
CC(C)c1nn(Cc2nnc(C3CCC3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5409648 IC50 370.0 nM
CC(C)c1nn(Cc2nnc(C3CCOC3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5440398 IC50 370.0 nM
CC(C)c1nn(Cc2nnc(-c3cccc(C#N)c3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5435864 IC50 380.0 nM
O=C(Cc1ccc(OC(F)F)cc1)Nc1cccc(O)c1 CHEMBL5209496 IC50 380.3 nM
CCOc1ccc(CC(=O)Nc2cccc(O)c2)cc1 CHEMBL5201588 IC50 387.3 nM
CC(C)c1nn(Cc2nnc(-c3ccnc(Cl)n3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5398744 IC50 390.0 nM
COCCN1C(=O)/C(=C2/C(=O)Nc3ccccc32)SC1=S CHEMBL5406324 IC50 400.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1cnn2c1CCCC2 CHEMBL5219182 IC50 410.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3c2)c(=O)cc1N1CC[C@H](C)C1 CHEMBL5422113 AC50 420.0 nM
CC1(Nc2nc(N)nc3cc(-c4cc[nH]n4)ccc23)CC1 CHEMBL5418076 EC50 420.0 nM
Cc1ncc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)s1 CHEMBL5219688 IC50 430.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1cnn2cccnc12 CHEMBL5220239 IC50 430.0 nM
CC(C)c1nn(Cc2nnc(-c3cccc(F)c3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5395360 IC50 430.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1ccco1 CHEMBL4802424 IC50 440.0 nM
Cc1ccc(-c2nnc(Cn3nc(C(C)C)n4c(cc5sc(Cl)cc54)c3=O)o2)cn1 CHEMBL5432954 IC50 440.0 nM
CCOC(=O)COC(=O)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL5407505 IC50 440.0 nM
CCOC(=O)COC(=O)Nc1c(C)cccc1C(C)C CHEMBL5427193 IC50 440.0 nM
O=C([N-]S(=O)(=O)c1ccco1)Nc1c2c(cc3c1CCC3)CCC2 CHEMBL4741204 IC50 450.0 nM
C=C1C(=O)[C@@]23C(CC[C@@H]1[C@H]2OC(=O)Nc1cccc(Cl)c1)[C@@]12CO[C@]3(O)[C@@H](O)[C@@H]1C(C)(C)CC[C@@H]2O CHEMBL5403920 IC50 450.0 nM
CCCOc1ccc(Cl)cc1Cn1cc(S(=O)(=O)c2ccc(C)cc2)nn1 CHEMBL5423405 Kd 480.0 nM
CCNc1nc(N)nc2cc(-c3cc[nH]n3)ccc12 CHEMBL5437671 EC50 480.0 nM
Nc1cc(NCCn2cccn2)c2ccc(-n3cccn3)cc2n1 CHEMBL5429684 EC50 490.0 nM
CC(C)c1nn(Cc2nnc(-c3cnccc3Cl)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5412116 IC50 500.0 nM
CC(C)c1nn(Cc2nnc(-c3cc(F)cnc3Cl)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5401205 IC50 500.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3c2)c(=O)cc1N1CC[C@@H]2C[C@@H]2C1 CHEMBL5401037 AC50 500.0 nM
C=CCN1C(=O)/C(=C2/C(=O)Nc3ccccc32)SC1=S CHEMBL5401920 IC50 500.0 nM
Cc1ccc(C)c(Nc2nc(C(=O)NS(=O)(=O)N(C)C)co2)c1 CHEMBL5402176 IC50 510.0 nM
CCN(Cc1nc2c(N)nc3cc(C4=CCCC4)ccc3c2[nH]1)C(C)=O CHEMBL4286476 EC50 520.0 nM
CC(C)c1nn(CC(=O)Nc2ccc3nncn3c2)c(=O)cc1N1CC[C@@H](F)C1 CHEMBL5412838 AC50 530.0 nM
Cc1ccc(C(F)(F)F)nc1Nc1nc(C(=O)NS(=O)(=O)N(C)C)co1 CHEMBL5405293 IC50 550.0 nM
O=C(Nc1cccc(Cl)c1)c1cc(N=Nc2ccc([N+](=O)[O-])cc2Cl)ccc1O CHEMBL1490692 IC50 566.0 nM
CCOC(=O)COC(=O)Nc1c(C)cc(C)cc1C CHEMBL5417052 IC50 590.0 nM
CCN(C)Cc1nc2c(N)nc3cc(-c4cc[nH]n4)ccc3c2[nH]1 CHEMBL4285025 EC50 600.0 nM
Cc1cc(=S)n2nc(Nc3c4c(cc5c3CCC5)CCC4)nc2[nH]1 CHEMBL5195278 IC50 600.0 nM
Cc1cccc(-c2ccc3c(c2)nc(N)c2nc(CN4CCCC4=O)[nH]c23)c1 CHEMBL4290288 EC50 610.0 nM
Nc1nc2cc(-n3cccn3)ccc2c2[nH]c(CN3C[C@H](c4ccccc4)CC3=O)nc12 CHEMBL4288029 EC50 630.0 nM
CN(C)[C@@H]1CCCC[C@H]1N(C)c1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c2nonc12 CHEMBL5207305 IC50 636.0 nM
Cc1cccc(C(=O)NNC(=O)c2c(O)c3ccccc3n(C)c2=O)c1 CHEMBL1331770 IC50 640.0 nM
CC(C)c1nn(Cc2nnc(-c3ccc(C(F)(F)F)nc3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5398591 IC50 640.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1ccc(N2C[C@@H]3[C@@H](CO)[C@@H]3C2)c2nonc12 CHEMBL5189690 IC50 641.0 nM
O=C(Cc1ccc(Br)cc1)Nc1cccc(O)c1 CHEMBL5197960 IC50 645.3 nM
COc1c(OC(C)=O)c(=O)n2c3ccccc3c3ccnc1c32 CHEMBL1703295 IC50 665.0 nM
CC(C)c1nn(Cc2nnc(-c3cncc(C(F)(F)F)c3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5423301 IC50 670.0 nM
COc1ccc(-c2cn(Cc3cc(Cl)ccc3OC)nn2)cc1 CHEMBL5435765 Kd 700.0 nM
CC(C)c1nn(Cc2nnc(-c3ccncc3Cl)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5409543 IC50 700.0 nM
CC(C)c1nn(Cc2nnc(-c3ncccc3Cl)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5400305 IC50 770.0 nM
O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1 CHEMBL1076347 IC50 805.0 nM
CCOC(=O)COC(=O)Nc1c(CC)cccc1CC CHEMBL5402869 IC50 810.0 nM
CC(=O)Oc1c(I)cc(I)cc1C(=O)Nc1ccc(Cl)cc1 CHEMBL236150 IC50 813.0 nM
CCOC(=O)c1coc(Nc2c3c(cc4c2CCC4)CCC3)n1 CHEMBL5420580 IC50 820.0 nM
Nc1nc2cc(-c3ccccc3F)ccc2c2[nH]c(CN3CCCC3=O)nc12 CHEMBL4283103 EC50 860.0 nM
CC(C)c1nn(Cc2nnc(-c3cccnc3Cl)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5421181 IC50 870.0 nM
c1ccc(C2Nc3ccccc3C3OCCCC23)cc1 CHEMBL1525362 IC50 881.0 nM
CCNc1cc(N)nc2cc(-n3cccn3)ccc12 CHEMBL5410936 EC50 900.0 nM
CC(C)c1nn(CC(=O)N[C@@H]2CCCN(C3CCC3)C2)c(=O)cc1-c1cccc(Cl)c1 CHEMBL5422764 IC50 910.0 nM
CCOC(=O)COC(=O)Nc1c(C)cccc1C CHEMBL5420080 IC50 930.0 nM
CCOC(=O)c1cnc(Nc2c3c(cc4c2CCC4)CCC3)o1 CHEMBL5424987 IC50 940.0 nM
CC(C)(C)OC(=O)NC1CN(c2ccc(S(=O)(=O)NC(=O)Nc3c4c(cc5c3CCC5)CCC4)c3nonc23)C1 CHEMBL5179909 IC50 947.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)c1cnccn1 CHEMBL5219226 IC50 960.0 nM
CC(C)c1nn(Cc2nnc(-c3cccc(C(F)(F)F)c3)o2)c(=O)c2cc3sc(Cl)cc3n12 CHEMBL5402114 IC50 970.0 nM
CCOC(=O)COC(=O)Nc1cc(C)ccc1C CHEMBL5404989 IC50 970.0 nM
O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/c1ccccn1 CHEMBL4744515 IC50 1000.0 nM
C/C1=C\CC[C@]2(C)O[C@@H]2[C@H]2OC(=O)[C@@H](CN(C)CCOc3no[n+]([O-])c3S(=O)(=O)c3ccccc3)[C@@H]2CC1 CHEMBL4740148 IC50 1000.0 nM
CCOC(=O)COC(=O)Nc1c(Cl)cccc1Cl CHEMBL5432654 IC50 1000.0 nM