Cc1cc(N2CCC[C@@H]2CC(=O)NCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL220632 IC50 0.12 nM
CCc1cc(N2CCC[C@@H]2CC(=O)NCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL220880 IC50 0.13 nM
CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]5(C)C=C(C#N)C(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 CHEMBL1093059 IC50 0.2 nM
COC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)[C@@H](CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL385324 IC50 0.24 nM
O=C(CC1CN(c2cccc(F)n2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL385325 IC50 0.28 nM
O=C(C[C@H]1CCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL376733 IC50 0.28 nM
Cc1cc(N2CCC[C@@H]2C(=O)NCCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL376632 IC50 0.29 nM
COC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL290548 IC50 0.38 nM
CN1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL373623 IC50 0.48 nM
O=C(NCCc1ccc2c(c1)OCO2)[C@H]1CCCN1c1ccnc(-n2ccnc2)n1 CHEMBL427062 IC50 0.48 nM
O=C(CC1CCCCN1c1cc(Cl)nc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223788 IC50 0.49 nM
O=C(CC1CN(C(=O)COCc2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL376713 IC50 0.5 nM
O=C(CC1CN(C(=O)c2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL385334 IC50 0.5 nM
O=C(CC1COCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL220932 IC50 0.5 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL442041 IC50 0.5 nM
CCc1cc(N2CCC[C@@H]2C(=O)NCCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL221208 IC50 0.52 nM
O=C(CC1CNCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL411343 IC50 0.55 nM
O=C(CC1CN(Cc2ccco2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL424928 IC50 0.58 nM
O=C(CC1CN(C(=O)c2ccco2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223782 IC50 0.67 nM
CS(=O)(=O)N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL373881 IC50 0.7 nM
Cc1cc(N2CCN(C(=O)C(C)C)[C@H](CC(=O)NCc3ccc4c(c3)OCO4)C2)nc(-n2ccnc2)n1 CHEMBL222362 IC50 0.75 nM
O=C(CC1CN(C(=O)OCc2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223792 IC50 0.8 nM
COc1ccc(CNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1 CHEMBL374681 IC50 0.8 nM
O=C(CC1CN(C(=O)Nc2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL374319 IC50 0.87 nM
CCOC(=O)CN1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL222364 IC50 0.93 nM
O=C(CC1CN(C(=O)NCc2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223791 IC50 0.96 nM
CC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL374132 IC50 1.0 nM
CC(C)OC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL220834 IC50 1.0 nM
CC(C)CCN1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL375404 IC50 1.0 nM
CNC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL223384 IC50 1.0 nM
O=C(CC1CN(Cc2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223634 IC50 1.0 nM
O=C(CC1CNCCN1c1cc(Cl)nc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL440473 IC50 1.1 nM
CN(C)c1cccc2c(S(=O)(=O)N3CCN(c4ccnc(-n5ccnc5)n4)C(CC(=O)NCc4ccc5c(c4)OCO5)C3)cccc12 CHEMBL223838 IC50 1.1 nM
O=C(CC1CN(C(=O)Oc2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223385 IC50 1.4 nM
COc1ccc(CNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1OC CHEMBL220121 IC50 1.5 nM
C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@@H]21 CHEMBL1800346 Ki 1.8 nM
CNC(=N)NCCC[C@H](N)C(=O)O CHEMBL256147 IC50 1.8 nM
Cc1cc(N2CCN(C(=O)C(C)C)C(CC(=O)NCc3ccc4c(c3)OCO4)C2)nc(-n2ccnc2)n1 CHEMBL220771 IC50 1.9 nM
NC1=NC(c2ccco2)Nc2c(F)ccc(F)c21 CHEMBL354788 IC50 2.0 nM
O=C(CC1CCCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223442 IC50 2.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2c(F)c(F)ccc12)c1cccc(Cl)c1 CHEMBL489724 EC50 2.0 nM
C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@@H]21 CHEMBL105792 Ki 2.0 nM
O=C(CC1CN(S(=O)(=O)c2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL220156 IC50 2.7 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc(F)cc1 CHEMBL436535 IC50 3.0 nM
Cn1cncc1C(=O)N(Cc1cc(=O)[nH]c2c(F)c(F)ccc12)c1cccc(Cl)c1 CHEMBL491923 EC50 3.0 nM
Cc1noc(C)c1C(=O)N(Cc1cc(=O)[nH]c2c(F)c(F)ccc12)c1cccc(Cl)c1 CHEMBL492090 EC50 3.0 nM
COc1ccc(CCNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1 CHEMBL387348 IC50 3.5 nM
COc1cccc(CNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)c1 CHEMBL387349 IC50 3.7 nM
N#Cc1ccc(Cl)cc1O[C@H](CCN)c1ccccc1 CHEMBL1762473 IC50 4.0 nM
N#Cc1ccc(Cl)cc1S[C@H](CCN)c1ccccc1 CHEMBL1762474 IC50 4.0 nM
Cc1ccc(C#N)c(S[C@H](CCN)c2ccccc2)n1 CHEMBL1762480 IC50 4.0 nM
Cc1cc(C2CCCN2CCN(C)Cc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911984 EC50 4.0 nM
Cc1cc(N2CCCCC2CC(=O)NCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL221264 IC50 4.1 nM
c1cncc(CN(CCCNCc2ccc3c(c2)OCO3)c2nc(-n3ccnc3)ns2)c1 CHEMBL1911998 EC50 5.0 nM
O=c1cc(CN(c2cccc(Cl)c2)c2cnccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944717 IC50 5.0 nM
COC(=O)N1CCN(c2cc(C)nc(-n3ccnc3)n2)CC1CC(=O)NCc1ccc2c(c1)OCO2 CHEMBL222619 IC50 5.4 nM
N#Cc1ccc(C(F)(F)F)nc1O[C@H](CCN)c1ccno1 CHEMBL1762481 IC50 5.4 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc(Cl)cc1 CHEMBL376237 IC50 5.7 nM
N#Cc1cc(F)c(Cl)cc1O[C@H](CCN)c1ccccc1 CHEMBL1762479 IC50 6.0 nM
c1cn(-c2nsc(N(CCCNCc3ccc4c(c3)OCO4)Cc3nccs3)n2)cn1 CHEMBL1911999 EC50 6.0 nM
CC[C@H]1SC(N)=N[C@@H]1C CHEMBL2096770 IC50 6.6 nM
CN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911882 IC50 7.0 nM
CC(=N)NCc1cccc(CN)c1 CHEMBL107251 Kd 7.0 nM
CC(=O)N1CCN(c2cc(C)nc(-n3ccnc3)n2)CC1CC(=O)NCc1ccc2c(c1)OCO2 CHEMBL219792 IC50 8.5 nM
C[C@@H]1CC(N)=N[C@@H]2CCC[C@H]12 CHEMBL191242 IC50 9.0 nM
O=C(c1c[nH]cn1)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL491897 EC50 9.0 nM
CNCC[C@@H](Oc1cc(Cl)ccc1C#N)c1ccccc1 CHEMBL1762472 IC50 9.0 nM
Cc1cc(C2CCCN2C(=O)NCCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911986 EC50 9.0 nM
CCCN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911990 EC50 9.0 nM
c1csc(CN(CCCNCc2ccc3c(c2)OCO3)c2nc(-n3ccnc3)ns2)c1 CHEMBL1912000 EC50 9.0 nM
CC(C)SC(=N)N CHEMBL483091 Ki 9.0 nM
CC[C@H]1[Se]C(N)=N[C@@H]1C CHEMBL178205 IC50 9.3 nM
CC[C@H]1N=C(N)[Se][C@@H]1C CHEMBL182193 IC50 9.4 nM
CCCc1cc(C)cc(N)n1 CHEMBL302657 IC50 10.0 nM
Cc1ccnc(N)c1 CHEMBL40833 IC50 10.0 nM
O=C(CC1CCCCN1c1cc(-n2ccnc2)ncn1)NCc1ccc2c(c1)OCO2 CHEMBL374552 IC50 10.0 nM
NC1=NC(c2cccs2)Nc2cccc(F)c21 CHEMBL1221607 IC50 10.0 nM
Cc1cc(N(C)CCCNCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911883 IC50 10.0 nM
Cc1ccccc1CN(Cc1cc(=O)[nH]c2c(F)c(F)ccc12)c1cnccn1 CHEMBL1944884 IC50 10.0 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)Nc1nc2ccccc2[nH]1 CHEMBL220559 IC50 11.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL522771 EC50 11.0 nM
CC1=C(C(=O)N(Cc2cc(=O)[nH]c3c(F)c(F)ccc23)c2cccc(Cl)c2)CNCC1 CHEMBL491922 EC50 11.0 nM
Cn1ncc2c(N(Cc3cc(=O)[nH]c4c(F)c(F)ccc34)c3cccc(Cl)c3)ncnc21 CHEMBL1945066 IC50 11.0 nM
CC(=N)Nc1ccc(C(=O)Nc2ccc(F)cc2)cc1 CHEMBL4633346 IC50 11.0 nM
COc1ccc(CCNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1OC CHEMBL223615 IC50 12.0 nM
Cc1cc(N2CCN(S(C)(=O)=O)C(CC(=O)NCc3ccc4c(c3)OCO4)C2)nc(-n2ccnc2)n1 CHEMBL424756 IC50 12.0 nM
Cc1cc(N2CCN(C)C(CC(=O)NCc3ccc4c(c3)OCO4)C2)nc(-n2ccnc2)n1 CHEMBL220122 IC50 12.0 nM
N#CCN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1909665 EC50 12.0 nM
O=c1cc(CN(Cc2ccccc2Cl)c2cnccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944721 IC50 12.0 nM
O=c1cc(CN(Cc2ccccc2F)c2cnccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944724 IC50 12.0 nM
O=c1cc(CN(c2cccc(Cl)c2)c2ncccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944718 IC50 13.0 nM
O=c1cc(CN(Cc2ccccc2)c2cnccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944720 IC50 13.0 nM
Cc1cc(CNC(=O)NCCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911982 EC50 14.0 nM
c1coc(CN(CCCNCc2ccc3c(c2)OCO3)c2nc(-n3ccnc3)ns2)c1 CHEMBL1912001 EC50 14.0 nM
O=c1cc(CN(c2cccc(Cl)c2)c2ccncn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944716 IC50 14.0 nM
CC1CCN=C(N)C1 CHEMBL6808 IC50 16.0 nM
Cc1noc(C)c1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL491727 EC50 16.0 nM
CS(=O)(=O)c1ccc(CNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1 CHEMBL374300 IC50 17.0 nM
[O-][n+]1cc(CN(c2cccc(Cl)c2)c2ncccn2)c2ccc(F)c(F)c2c1 CHEMBL1945068 IC50 17.0 nM
CCSC(=N)NCCC[C@H](N)C(=O)O CHEMBL106871 Ki 17.0 nM
COC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)/C=C/c1ccc(C(F)(F)F)cc1 CHEMBL5087665 Kd 18.0 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc(OC(F)(F)F)cc1 CHEMBL220270 IC50 19.0 nM
Cc1cc(Oc2ccc3c(c2)OCO3)nc(Oc2ccc(-n3ccnc3)cc2Cl)n1 CHEMBL244395 IC50 19.0 nM
Cc1ncsc1C(=O)N(Cc1c[n+]([O-])cc2c(F)c(F)ccc12)c1cccc(Cl)c1 CHEMBL524109 EC50 19.0 nM
NC1=NC(C2CCC2)Nc2cccc(F)c21 CHEMBL352659 IC50 20.0 nM
CCC1N=C(N)CC1C CHEMBL185024 IC50 20.0 nM
Cc1cc(CCCCNCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911981 EC50 20.0 nM
CSCC(=N)Nc1cccc(CN)c1 CHEMBL555794 Ki 21.0 nM
CC[C@@H]1N=C(N)[Se][C@H]1C CHEMBL179441 IC50 21.0 nM
CC[C@H]1N=C(N)[Se][C@H]1C CHEMBL178622 IC50 21.0 nM
C[C@@H]1CC(N)=N[C@@H]2CCCC[C@H]12 CHEMBL191675 IC50 22.0 nM
CNCC[C@@H](Oc1cc(Cl)ccc1Cl)c1ccccc1 CHEMBL1762471 IC50 22.0 nM
Cc1ccc(CNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1 CHEMBL223043 IC50 23.0 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccccc1 CHEMBL220269 IC50 25.0 nM
Cc1cc(N2CCN(Cc3ccccc3)C(CC(=O)NCc3ccc4c(c3)OCO4)C2)nc(-n2ccnc2)n1 CHEMBL220123 IC50 25.0 nM
CCCC1CCCCC/C(N)=N\1 CHEMBL113438 IC50 26.0 nM
Cc1ncsc1C(=O)N(Cc1c(F)c(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL522815 EC50 26.0 nM
N#Cc1ccc(C(=O)N2CCC3(CC2)N=C(N)c2c(F)cccc2N3)cc1 CHEMBL367556 IC50 27.0 nM
Cc1cc(N)nc(CC(C)C)c1 CHEMBL294609 IC50 28.0 nM
CN(C)c1cc(N(Cc2cc(=O)[nH]c3c(F)c(F)ccc23)c2cccc(Cl)c2)ncn1 CHEMBL1944890 IC50 28.0 nM
Cc1cc(C(C)NCCN(C)Cc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911894 EC50 29.0 nM
N=C(N)[C@H]1CCN1 CHEMBL1783094 IC50 30.0 nM
Cc1cc(C2CCCN2C(=O)CNCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911985 EC50 30.0 nM
NC1=NC(CCNC(=O)c2ccoc2)Nc2c(F)ccc(F)c21 CHEMBL1221608 IC50 31.0 nM
O=c1cc(CN(c2cccc(Cl)c2)c2ccccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944712 IC50 31.0 nM
CC(C)N(Cc1cc(Cl)ccc1C#N)C1CCNCC1 CHEMBL428248 IC50 32.0 nM
C/N=C/N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL373546 IC50 33.0 nM
Cc1nccc(N(Cc2cc(=O)[nH]c3c(F)c(F)ccc23)c2cccc(Cl)c2)n1 CHEMBL1944886 IC50 33.0 nM
CC[C@@H]1[Se]C(N)=N[C@H]1C CHEMBL178373 IC50 34.0 nM
COC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)[C@H](CC(=O)NCc2ccc3c(c2)OCO3)C1 CHEMBL220511 IC50 34.0 nM
CCOC(=O)CN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911993 EC50 34.0 nM
CCOC(=O)N1CCC2(CC1)N=C(N)c1c(F)cccc1N2 CHEMBL174290 IC50 35.0 nM
O=C(CC1CCCCN1c1cc(-n2ccnc2)nc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL266768 IC50 35.0 nM
N#Cc1ccc(C(=O)N2CCC3(CC2)N=C(N)c2c(F)ccc(F)c2N3)cn1 CHEMBL447183 IC50 35.0 nM
Cc1cc(C2CCCN2CC(=O)NCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911987 EC50 36.0 nM
C[C@@H]1CC(N)=N[C@H]2CCCC[C@@H]12 CHEMBL365804 IC50 38.0 nM
COc1ccnc(CCc2nc3cc(-c4ccccc4)cnc3[nH]2)c1 CHEMBL1800534 pIC50 38.9 nM
CSCCOC(=O)N1CCC2(CC1)N=C(N)c1c(F)cccc1N2 CHEMBL173505 IC50 39.0 nM
C#CC1Cc2ccsc2C(N)=N1 CHEMBL8292 IC50 40.0 nM
CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC(=O)C4[C@@]5(C)C=C(C#N)C(=O)C(C)(C)C5CC[C@]43C)C2C1 CHEMBL196027 IC50 40.0 nM
CCC[C@@H]1COc2ccsc2C(N)=N1 CHEMBL1221703 IC50 40.0 nM
C[C@H]1CN=C(N)c2sccc2O1 CHEMBL1221702 IC50 40.0 nM
CCC[C@H]1COc2ccsc2C(=N)N1 CHEMBL1230023 IC50 40.0 nM
Oc1ccc(CN(CCCNCc2ccc3c(c2)OCO3)c2nc(-n3ccnc3)ns2)cc1 CHEMBL1912003 EC50 42.0 nM
O=c1cc(CN(c2cccc(Cl)c2)c2cccnn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944715 IC50 43.0 nM
Cc1cc(C)nc(N)c1 CHEMBL59925 IC50 45.0 nM
CCCCc1cc(C)cc(N)n1 CHEMBL292507 IC50 46.0 nM
CCOC(=O)N1CCC2(CC1)N=C(N)c1c(Cl)cccc1N2 CHEMBL366978 IC50 47.0 nM
N=C(N)SCCc1cccc(CCSC(=N)N)c1 CHEMBL107201 Ki 47.0 nM
N#Cc1ccc(C(=O)N2CCC3(CC2)N=C(N)c2c(F)ccc(F)c2N3)cc1 CHEMBL174310 IC50 48.0 nM
CN(CCCNCc1ccc2c(c1)OCCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911886 EC50 48.0 nM
Cc1ccncc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL491570 EC50 49.0 nM
C=CCC1CC(C)=CC(N)=N1 CHEMBL72316 IC50 50.0 nM
NC1=NC(c2ccc(F)cc2)Nc2cccc(F)c21 CHEMBL354516 IC50 50.0 nM
NC1=NC(C2CC2)Cc2ccsc21 CHEMBL8365 IC50 51.0 nM
CCC(CCNC)Oc1cc(Cl)ccc1C#N CHEMBL1762478 IC50 51.0 nM
O=C(CC1CCCCN1c1nccc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223515 IC50 52.0 nM
COc1ccnc(NC2CCN(C(=O)c3ccc(Cl)cc3)CC2)c1 CHEMBL112866 IC50 53.0 nM
O=C(c1cncs1)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL522478 EC50 53.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2cc(F)ccc12)c1cccc(Cl)c1 CHEMBL490559 EC50 53.0 nM
Cc1cc(N(Cc2cc(=O)[nH]c3c(F)c(F)ccc23)c2cccc(Cl)c2)ncn1 CHEMBL1944887 IC50 53.0 nM
CCCCc1cnc2[nH]c(CCc3cc(OC)ccn3)nc2c1 CHEMBL1800533 pIC50 54.95 nM
c1cn(-c2ccc(Oc3nccc(Oc4ccc5c(c4)OCO5)n3)cc2)cn1 CHEMBL243978 IC50 55.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(C#N)c1 CHEMBL522290 EC50 56.0 nM
c1cn(-c2nsc(N(CCCNCc3ccc4c(c3)OCO4)C3CC3)n2)cn1 CHEMBL1911991 EC50 56.0 nM
Cc1cc(N)nc(CCCF)c1 CHEMBL443862 IC50 57.6 nM
Cc1ccnc(N)c1N CHEMBL61427 IC50 59.0 nM
CNC(=O)CN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911994 EC50 59.0 nM
CCCC1CC(C)=CC(N)=N1 CHEMBL75496 IC50 60.0 nM
COc1cc(N(Cc2cc(=O)[nH]c3c(F)c(F)ccc23)c2cccc(Cl)c2)ncn1 CHEMBL1945065 IC50 61.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(F)c1 CHEMBL490935 EC50 62.0 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccco1 CHEMBL220630 IC50 63.0 nM
Cc1ccc(S(=O)(=O)NCc2cccc(CNC(=N)c3ccccc3)c2)cc1 CHEMBL5396622 IC50 65.0 nM
CC[C@@H]1[Se]C(N)=N[C@@H]1C CHEMBL362691 IC50 66.0 nM
COc1ccc(NC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1OC CHEMBL223614 IC50 66.0 nM
CN(C)c1ccc(CNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1 CHEMBL223045 IC50 66.0 nM
NC1=NC2(CCN(C(=O)c3ccsc3)CC2)Nc2cccc(F)c21 CHEMBL170580 IC50 67.0 nM
O=C(CC1CCCCN1c1cc(-c2ccccc2)nc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL220064 IC50 67.0 nM
O=C(CC1CN(Cc2cccc3ccccc23)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL373919 IC50 69.0 nM
CC(=N)NCCSCC[C@H](N)C(=O)O CHEMBL114551 IC50 70.0 nM
COc1ccnc(NC2CCN(C(=O)c3ccc(C#N)nc3)CC2)c1 CHEMBL1800347 pIC50 70.79 nM
COc1ccnc(NC2CCN(C(=O)c3ccc(C#N)cc3)CC2)c1 CHEMBL114500 IC50 71.0 nM
CNCC[C@@H](Oc1cc(C(F)(F)F)ccc1C#N)c1ccccc1 CHEMBL1762475 IC50 71.0 nM
Cn1cnc(CN(CCCNCc2ccc3c(c2)OCO3)c2nc(-n3ccnc3)ns2)c1 CHEMBL1912002 EC50 71.0 nM
c1cn(-c2ccc(O[C@H]3CCCN(Cc4ccc5c(c4)OCO5)C3)cc2)cn1 CHEMBL232827 IC50 72.0 nM
c1cn(-c2ccc(Oc3ccnc(Oc4ccc5c(c4)OCO5)n3)cc2)cn1 CHEMBL244182 IC50 74.0 nM
Cc1ccnc(N)c1C CHEMBL61939 IC50 76.0 nM
Cc1cc(N)nc(CCC(C)C)c1 CHEMBL60372 IC50 76.0 nM
O=C(CC1CCCCN1c1cccc(-n2ccnc2)c1)NCc1ccc2c(c1)OCO2 CHEMBL220213 IC50 77.0 nM
O=c1cc(CN(c2cccnc2)c2cccc(Cl)c2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944713 IC50 77.0 nM
O=c1cc(CN(Cc2ccc(Cl)cc2)c2cnccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944723 IC50 77.0 nM
c1cc(Oc2ccc(-n3ccnc3)cc2)nc(Oc2ccc3c(c2)OCO3)c1 CHEMBL243976 IC50 78.0 nM
O=c1cc(CN(Cc2ccccn2)c2cnccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944885 IC50 78.0 nM
CC1CC(N)=NC(C)C1 CHEMBL269076 IC50 80.0 nM
CC[C@@H]1N=C(N)[Se][C@@H]1C CHEMBL178389 IC50 80.0 nM
CN(C)C(=O)CN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911995 EC50 80.0 nM
NC(=O)CN(CCCNCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911992 EC50 81.0 nM
COc1ccnc(CCc2nc3cccnc3[nH]2)c1 CHEMBL1738840 pIC50 81.28 nM
Cc1ncsc1C(=O)N(Cc1c[n+]([O-])cc2c(F)cccc12)c1cccc(Cl)c1 CHEMBL490899 EC50 87.0 nM
CC(C)Cc1nc2nccnc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801506 EC50 88.0 nM
CCOC(=O)N1CCC(Nc2cc(OC)ccn2)CC1 CHEMBL112246 IC50 89.0 nM
NC1=NC(c2ccco2)Cc2ccsc21 CHEMBL274405 IC50 89.0 nM
Cc1cnccc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL512870 EC50 89.0 nM
CCCC1CCCCC(N)=N1 CHEMBL553271 Ki 90.0 nM
Cc1cc(Oc2ccc3c(c2)OCO3)nc(Oc2ccc(-n3ccnc3)cc2)n1 CHEMBL390674 IC50 90.0 nM
CN1CCC(N(C)Cc2cc(Cl)ccc2[N+](=O)[O-])CC1 CHEMBL272708 IC50 90.0 nM
c1cn(-c2nsc(N(CCCNCc3ccc4c(c3)OCO4)Cc3ccc4occc4c3)n2)cn1 CHEMBL1912004 EC50 90.0 nM
O=c1cc(Cn2c(C3CCC3)nc3nccnc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801504 EC50 91.0 nM
Cc1cc(Oc2ccc3c(c2)OCO3)nc(Oc2ccc(-n3ccnc3)cc2F)n1 CHEMBL388708 IC50 92.0 nM
CC(=N)NCCCC[C@H](N)C(=O)O CHEMBL7889 IC50 100.0 nM
Cc1cc(N2CCNC(CC(=O)NCc3ccc4c(c3)OCO4)C2)nc(-n2ccnc2)n1 CHEMBL221320 IC50 100.0 nM
CCN(Cc1cc(Cl)ccc1C#N)C1CCNCC1 CHEMBL403952 IC50 100.0 nM
Cc1cccc(N(Cc2cc(=O)[nH]c3c(F)cccc23)C(=O)c2scnc2C)c1 CHEMBL490763 EC50 100.0 nM
Cc1cc(N)nc(C(C)C)c1 CHEMBL299677 IC50 110.0 nM
C#CC1Cc2sccc2C(N)=N1 CHEMBL8281 IC50 110.0 nM
CNCC[C@@H](Oc1cc(OC)ccc1C#N)c1ccccc1 CHEMBL1762476 IC50 110.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)/C=C/c1ccc(C(F)(F)F)cc1 CHEMBL5090551 IC50 110.0 nM
COc1ccnc(CSc2nc3cccnc3[nH]2)c1 CHEMBL1800348 pIC50 114.82 nM
N=C(Nc1cccc(CN)c1)c1cccs1 CHEMBL555715 Ki 120.0 nM
c1cn(-c2ccc(NC3CCCN(Cc4ccc5c(c4)OCO5)C3)cc2)cn1 CHEMBL233031 IC50 120.0 nM
Cc1cc(N)nc(CCNC(=O)c2ccc(C#N)cc2)c1 CHEMBL1221659 IC50 120.0 nM
N=C(N)[C@H]1CCCN1 CHEMBL1783097 IC50 120.0 nM
O=c1cc(Cn2c(C3CC(F)(F)C3)nc3nccnc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801059 EC50 120.0 nM
Cc1cnc(Oc2ccc(-n3ccnc3)cc2)nc1Oc1ccc2c(c1)OCO2 CHEMBL244184 IC50 130.0 nM
CCCN(Cc1cc(Cl)ccc1C#N)C1CCNCC1 CHEMBL256378 IC50 130.0 nM
NCc1ccc(C(=O)N2CCC3(CC2)N=C(N)c2c(F)cccc2N3)cc1 CHEMBL1221657 IC50 130.0 nM
O=c1cc(CN(c2ccncc2)c2cccc(Cl)c2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944714 IC50 130.0 nM
C[C@H]1CC(N)=N[C@H]2CCC[C@H]21 CHEMBL433589 IC50 133.0 nM
N=C(N)SCCF CHEMBL148951 IC50 140.0 nM
CC(=N)NCc1cccc(CN)c1 CHEMBL544788 Ki 140.0 nM
COc1ccnc(CCc2nc3c(C)ccnc3[nH]2)c1 CHEMBL1800528 pIC50 144.54 nM
NC1=NC(c2cccs2)Cc2ccsc21 CHEMBL8041 IC50 150.0 nM
CC#CC1Cc2ccsc2C(N)=N1 CHEMBL8302 IC50 150.0 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc(C(F)(F)F)cc1 CHEMBL373868 IC50 150.0 nM
O=c1cc(Cn2c(C3CCC3)nc3c(C(F)(F)F)ccnc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801503 EC50 150.0 nM
NC1=NC(CC[N+](=O)[O-])CCCC1 CHEMBL315194 IC50 152.0 nM
COc1ccnc(CSC)c1 CHEMBL1800523 pIC50 154.88 nM
CCSC(=N)N CHEMBL321691 IC50 160.0 nM
N=C(Nc1cccc(CN)c1)c1ccco1 CHEMBL552825 Ki 160.0 nM
CCC1CC(N)=NC1C CHEMBL363477 IC50 160.0 nM
NC1=NCCCOC1 CHEMBL362772 IC50 160.0 nM
N#Cc1ccc(Cl)cc1CN(CC1CC1)C1CCNCC1 CHEMBL256618 IC50 160.0 nM
CC(C)C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL470908 EC50 160.0 nM
N=C(Nc1cccc(CN)c1)c1ccco1 CHEMBL96680 Ki 160.0 nM
CN(C)c1ccc(CN(CCCNCc2ccc3c(c2)OCO3)c2nc(-n3ccnc3)ns2)cc1 CHEMBL1912005 EC50 163.0 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc([N+](=O)[O-])cc1 CHEMBL374486 IC50 168.0 nM
CCC1N=C(N)CC1C CHEMBL552935 IC50 170.0 nM
CC1=CC(N)=N[C@@H]2CCC[C@H]12 CHEMBL75428 IC50 170.0 nM
Cc1cc(N)nc(CCCCF)c1 CHEMBL509542 IC50 170.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1 CHEMBL491723 EC50 170.0 nM
CN(C)c1ccnc2c1nc(C1CCC1)n2Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801502 EC50 170.0 nM
CC[C@H](C)[C@H](NC(=O)/C=C/c1ccc(C(F)(F)F)cc1)C(=O)OC CHEMBL5081853 IC50 178.0 nM
CC1=CC(N)=NC(C)C1 CHEMBL74919 IC50 180.0 nM
O=C(CC1CCCCN1c1cc(C(F)(F)F)nc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 CHEMBL223840 IC50 180.0 nM
CN(Cc1cc(Cl)ccc1C#N)C1CCCNC1 CHEMBL271248 IC50 180.0 nM
N=C(N)C1C=CCN1 CHEMBL1783093 IC50 180.0 nM
O=c1cc(Cn2c(C3CCC3)nc3cccnc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801498 EC50 180.0 nM
NC1=N[C@H]2CCCC[C@H]2CC1 CHEMBL364230 IC50 186.0 nM
COc1ccnc(CCc2nc3cc(Br)cnc3[nH]2)c1 CHEMBL1800526 pIC50 186.21 nM
COC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)/C=C/c1ccc(F)cc1 CHEMBL5085929 IC50 188.0 nM
NC1=NC(C2CC2)Cc2sccc21 CHEMBL8105 IC50 190.0 nM
C=CCC1CCCCC(N)=N1 CHEMBL544693 IC50 190.0 nM
CCC[C@H]1CSCCC(N)=N1 CHEMBL186431 IC50 190.0 nM
O=c1cc(Cn2c(C3CCC3)nc3nccnc32)c2cccc(F)c2[nH]1 CHEMBL1801060 EC50 190.0 nM
COC(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccc(C(F)(F)F)cc1 CHEMBL5082466 IC50 195.0 nM
CC1=CC(N)=NCC1 CHEMBL75304 IC50 200.0 nM
CCCC1CCCC(N)=N1 CHEMBL6760 IC50 200.0 nM
NC1=NC(c2ccco2)Nc2ccccc21 CHEMBL368636 IC50 200.0 nM
CC1CN=C(N)C1 CHEMBL183012 IC50 200.0 nM
CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]5(C)C=CC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 CHEMBL1765578 IC50 200.0 nM
CC(=N)NCc1ccccc1 CHEMBL462334 IC50 200.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1ccccc1 CHEMBL491127 EC50 200.0 nM
Cc1ncsc1C(=O)N(Cc1cncc2c(F)c(F)ccc12)c1cccc(Cl)c1 CHEMBL492105 EC50 200.0 nM
N=C(N)[C@@H]1CCN1 CHEMBL1783095 IC50 200.0 nM
Fc1ccc2c(CN(c3cccc(Cl)c3)c3ncccn3)cncc2c1F CHEMBL1945067 IC50 200.0 nM
CN1CCC(N(C)Cc2cc(Br)ccc2C#N)CC1 CHEMBL436643 IC50 210.0 nM
COc1ccnc2c1nc(C1CCC1)n2Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801501 EC50 210.0 nM
O=c1cc(CN(c2cncnc2)c2cccc(Cl)c2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944719 IC50 210.0 nM
Cc1cc(Oc2ccc3c(c2)OCO3)nc(Oc2ccc(-n3ccnc3)cc2C(F)(F)F)n1 CHEMBL244396 IC50 220.0 nM
CN(C)CCCN(C)c1cc(Oc2ccc(-n3ccnc3)cc2)nc(Cc2ccc3c(c2)OCO3)n1 CHEMBL244599 IC50 220.0 nM
Cc1cc(N)nc(CC(C)F)c1 CHEMBL450726 IC50 220.0 nM
O=c1cc(Cn2c(C3CC(F)(F)C3)nc3nccnc32)c2cccc(F)c2[nH]1 CHEMBL1801062 EC50 220.0 nM
O=c1cc(CN(Cc2cccc(Cl)c2)c2cnccn2)c2ccc(F)c(F)c2[nH]1 CHEMBL1944722 IC50 220.0 nM
CCCCCC1N=C(N)CC1C(F)(F)F CHEMBL545059 IC50 230.0 nM
CCc1ccnc(N)c1 CHEMBL62077 IC50 230.0 nM
CN(CCCNCCc1ccc2c(c1)OCO2)c1nc(-n2ccnc2)ns1 CHEMBL1911893 EC50 230.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1ccc(Cl)cc1 CHEMBL490764 EC50 240.0 nM
CCCSC(=N)N CHEMBL483092 Ki 240.0 nM
CCCCCC1N=C(N)CC1C CHEMBL542710 IC50 250.0 nM
CCCCC[C@H]1NC(=N)C[C@H]1C CHEMBL322480 IC50 250.0 nM
c1cn(-c2ccc(OC3CCCN(Cc4ccc5c(c4)OCO5)C3)cc2)cn1 CHEMBL232825 IC50 250.0 nM
CN(Cc1cc(Cl)ccc1C#N)C1CCN(CC2CC2)CC1 CHEMBL256620 IC50 250.0 nM
CCC(NC(C)=N)c1ccccc1 CHEMBL450583 IC50 250.0 nM
CCOC(=O)N1CCC(NC(C)=N)CC1 CHEMBL473674 IC50 250.0 nM
CC(C)CN(Cc1cc(Cl)ccc1C#N)[C@@H]1CCCNC1 CHEMBL255599 IC50 260.0 nM
O=c1cc(Cn2c(C3CCC3)nc3ccccc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801487 EC50 260.0 nM
Nc1ccc(CNC(=O)CC2CCCCN2c2ccnc(-n3ccnc3)n2)cc1 CHEMBL219896 IC50 270.0 nM
CN(Cc1cc(Cl)ccc1C#N)C1CCN(Cc2ccccc2)CC1 CHEMBL257007 IC50 270.0 nM
Cc1ccnc2c1nc(C1CCC1)n2Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801499 EC50 270.0 nM
O=c1cc(Cn2c(C3CCC3)nc3c(Cl)ccnc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801500 EC50 270.0 nM
O=c1cc(Cn2c(C3CCCC3)nc3nccnc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801505 EC50 280.0 nM
C/C=C/c1cc(C)cc(N)n1 CHEMBL501620 IC50 282.0 nM
COc1ccccc1CNC(=O)CC1CCCCN1c1ccnc(-n2ccnc2)n1 CHEMBL223839 IC50 283.0 nM
CCCC1CSCCC(N)=N1 CHEMBL186969 IC50 290.0 nM
CC(C)CN(Cc1cc(Cl)ccc1C#N)C1CCCNC1 CHEMBL271246 IC50 290.0 nM
CN1CCC(N(C)Cc2cc(Cl)ccc2C#N)CC1 CHEMBL256249 IC50 290.0 nM
O=[N+]([O-])c1cccc2c(Br)n[nH]c12 CHEMBL479014 IC50 290.0 nM
CC(C)Cc1nc2nccnc2n1Cc1cc(=O)[nH]c2c(F)cccc12 CHEMBL1801061 EC50 290.0 nM
Cc1cc(C(C)NCCOCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911989 EC50 290.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)/C=C/c1ccc(F)cc1 CHEMBL5086634 IC50 291.0 nM
Cc1cc(CNC(=O)CNCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 CHEMBL1911983 EC50 293.0 nM
CCCC1N=C(N)CC1C CHEMBL541081 IC50 300.0 nM
CCOC(=O)N1CCC2(CC1)N=C(N)c1sccc1N2 CHEMBL170176 IC50 300.0 nM
CC1CC(N)=NC1C CHEMBL185584 IC50 300.0 nM
N=C1CCCCN1 CHEMBL269058 IC50 300.0 nM
CSC(=N)NCCC[C@H](N)C(=O)O CHEMBL106516 IC50 300.0 nM
Cc1cc(N2CCN(C(=O)C(C)C)[C@@H](CC(=O)NCc3ccc4c(c3)OCO4)C2)nc(-n2ccnc2)n1 CHEMBL220824 IC50 300.0 nM
CN(Cc1cc(Cl)ccc1C#N)C1CCN(CCc2ccccc2)CC1 CHEMBL428069 IC50 300.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2ccc(F)cc12)c1cccc(Cl)c1 CHEMBL522954 EC50 300.0 nM
CC1=C(C)C(N)=NCC1 CHEMBL75484 IC50 310.0 nM
CCC1CSCCC(N)=N1 CHEMBL185833 IC50 310.0 nM
CC(C)CC1CSCCC(N)=N1 CHEMBL185919 IC50 320.0 nM
CC(C)CN(Cc1cc(Cl)ccc1C#N)[C@H]1CCCN(C)C1 CHEMBL256414 IC50 320.0 nM
CCc1cc(C)cc(N)n1 CHEMBL294084 IC50 330.0 nM
CC(C)CN(Cc1cc(Cl)ccc1C#N)[C@H]1CCCNC1 CHEMBL256415 IC50 330.0 nM
CN(Cc1cc(Cl)ccc1C#N)C1CCNCC1 CHEMBL272697 IC50 330.0 nM
CC(=N)NCCC[C@H](N)C(=O)O CHEMBL11471 Ki 340.0 nM
CC[C@H]1[Se]C(N)=N[C@H]1C CHEMBL179126 IC50 340.0 nM
CCCCN1CCC(N(C)Cc2cc(Cl)ccc2C#N)CC1 CHEMBL257008 IC50 340.0 nM
Cc1cnccc1-c1nc2ccccc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801481 EC50 340.0 nM
CCOC(=O)N1CCC(Nc2cc(C)ccn2)CC1 CHEMBL420671 IC50 350.0 nM
CC(=N)NCc1cccc(CNCc2ccncc2)c1 CHEMBL490870 IC50 350.0 nM
Cc1ncccc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL492088 EC50 350.0 nM
Cc1cccnc1N(Cc1cc(=O)[nH]c2c(F)c(F)ccc12)c1cccc(Cl)c1 CHEMBL1944888 IC50 350.0 nM
Nc1cccc(-c2ccc(OCCN3CCCC3)c3c2CCCC3)n1 CHEMBL42968 IC50 357.7 nM
COc1ccc(CNCCCN(C)c2nc(-n3ccnc3)ns2)cc1 CHEMBL1911887 EC50 360.0 nM
CCN1CCC(N(C)Cc2cc(Cl)ccc2C#N)CC1 CHEMBL258310 IC50 370.0 nM
N=C(N)C1CCC1 CHEMBL1783072 IC50 380.0 nM
CC(C)Cc1nc2ccccc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801490 EC50 380.0 nM
COc1ccnc(CCc2nc3ccc(OC)nc3[nH]2)c1 CHEMBL1800527 pIC50 380.19 nM
CC(C)CN(Cc1cc(Cl)ccc1C#N)C1CCNCC1 CHEMBL402217 IC50 390.0 nM
NC1=NC(c2cccs2)Nc2ccccc21 CHEMBL170770 IC50 400.0 nM
CC(C)CCN1CCC(N(C)Cc2cc(Cl)ccc2C#N)CC1 CHEMBL402425 IC50 400.0 nM
NC1=N[C@H](COc2ccc3c(c2)CCNC3)COc2ccsc21 CHEMBL1221704 IC50 400.0 nM
CC1=CC(N)=NCC1(C)C CHEMBL308310 IC50 420.0 nM
CN1CCC(N(C)Cc2cc(Cl)ccc2Br)CC1 CHEMBL256069 IC50 420.0 nM
Cc1cccnc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL522467 EC50 420.0 nM
CC[C@H](C)[C@H](NC(=O)/C=C/c1ccc(F)cc1)C(=O)OC CHEMBL5093141 IC50 421.0 nM
CC(=N)NCc1cccc(CNC(=O)CCC(=O)O)c1 CHEMBL3589087 IC50 428.0 nM
COC(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccc(F)cc1 CHEMBL5070156 IC50 434.0 nM
Nc1cccc(-c2ccc(OCCN3CCCC3)c3c2CCC3)n1 CHEMBL290476 IC50 450.0 nM
Cc1c(F)c(Oc2ccc(-n3ccnc3)cc2)nc(Oc2ccc3c(c2)OCO3)c1F CHEMBL243977 IC50 450.0 nM
CC(=N)N[C@@H](C)c1ccccc1 CHEMBL448703 IC50 450.0 nM
O=c1cc(Cn2c(C3CCC3)nc3ccncc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801497 EC50 460.0 nM
CC(C)CN(Cc1cc(Cl)ccc1C#N)[C@@H]1CCCN(C)C1 CHEMBL256402 IC50 470.0 nM
N=C(CF)Nc1cccc(CN)c1 CHEMBL555584 Ki 480.0 nM
CC1CCCC(N)=N1 CHEMBL265672 IC50 500.0 nM
NC1=NC(C(F)(F)F)CCC1 CHEMBL267038 IC50 500.0 nM
CCCCC1CCCCC(N)=N1 CHEMBL543514 IC50 500.0 nM
CCC1CN=C(N)C1 CHEMBL360616 IC50 500.0 nM
CCCCC1CSCCC(N)=N1 CHEMBL186091 IC50 500.0 nM
CC(=N)NCc1cccc(CNS(=O)(=O)c2ccc(C)cc2)c1 CHEMBL490886 IC50 500.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2ccccc12)c1ccccc1 CHEMBL491126 EC50 500.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)[nH]c2cccc(F)c12)c1cccc(Cl)c1 CHEMBL490560 EC50 500.0 nM
CC1=CC(N)=NCC1C CHEMBL75905 IC50 510.0 nM
COCCOc1ccnc2[nH]c(CCc3cc(OC)ccn3)nc12 CHEMBL1800531 pIC50 512.86 nM
CN(C)CCOc1ccc(-c2cccc(N)n2)c2c1CCCC2 CHEMBL43815 IC50 517.0 nM
CCCCC1CCCCC(N)=N1 CHEMBL89288 IC50 517.0 nM
NC1=N[C@H]2CCCC[C@@H]2CC1 CHEMBL193007 IC50 528.0 nM
COc1ccnc(NC2CCN(C(=O)c3ccccc3)CC2)c1 CHEMBL112747 IC50 530.0 nM
NC1=Nc2cc(CCNCc3cccc(Cl)c3)ccc2[C@H]2CCC[C@@H]12 CHEMBL542132 IC50 530.0 nM
O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccccn1 CHEMBL220558 IC50 539.0 nM
O=c1cc(Cn2c(CC3CCC3)nc3ccccc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801493 EC50 540.0 nM
NC1=NC(c2ccccc2)Cc2cccc(F)c21 CHEMBL414608 IC50 550.0 nM
CCCCN(Cc1cc(Cl)ccc1C#N)C1CCNCC1 CHEMBL256376 IC50 570.0 nM
NC1=Nc2cc(CCCNCc3cccc(Cl)c3)ccc2[C@H]2CCC[C@@H]12 CHEMBL162416 IC50 580.0 nM
NC1=Nc2cc(CCCNCc3cccc(Cl)c3)ccc2[C@H]2CCC[C@@H]12 CHEMBL545441 IC50 580.0 nM
c1cn(-c2ccc(OC3CCCN(Cc4ccc5c(c4)OCO5)C3)nn2)cn1 CHEMBL233032 IC50 590.0 nM
O=c1cc(Cn2c(C3CCC3)nc3ncccc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801495 EC50 590.0 nM
CN(C)CCOc1ccc(-c2cccc(N)n2)c2c1CCC2 CHEMBL43678 IC50 592.0 nM
COC(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccccc1Cl CHEMBL5091916 IC50 594.0 nM
C/N=C(/N)Nc1ccccc1CC(N)C(=O)O CHEMBL49881 Ki 600.0 nM
Cc1ccc(N)nc1 CHEMBL61990 IC50 600.0 nM
CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CCC4[C@@]5(C)C=C(C#N)C(=O)C(C)(C)C5CC[C@]43C)C2C1 CHEMBL195352 IC50 600.0 nM
O=c1cc(Cn2c(CC3CC3)nc3ccccc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801492 EC50 600.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)/C=C/c1ccccc1Cl CHEMBL5083240 IC50 630.0 nM
CC[C@H](C)[C@H](NC(=O)/C=C/c1ccc(Cl)c(Cl)c1)C(=O)OC CHEMBL5094665 IC50 640.0 nM
CC[C@H](C)[C@H](NC(=O)/C=C/c1ccccc1Cl)C(=O)OC CHEMBL5082696 IC50 645.0 nM
CCCCC1N=C(N)CC1C CHEMBL553119 IC50 660.0 nM
CN(Cc1cc(Cl)ccc1C#N)C1CCCNCC1 CHEMBL271038 IC50 660.0 nM
N#Cc1ccc(Cl)cc1CN(c1ccccc1)C1CCNCC1 CHEMBL271247 IC50 660.0 nM
CNCCCc1cc(C)cc(N)n1 CHEMBL5191295 Ki 669.0 nM
N=C(NCCC[C@H](N)C(=O)O)N[N+](=O)[O-] CHEMBL227744 Ki 670.0 nM
CCCN1CCC(N(C)Cc2cc(Cl)ccc2C#N)CC1 CHEMBL272271 IC50 670.0 nM
CC(N)C(=O)Cc1cn[nH]c1 CHEMBL4635568 IC50 681.0 nM
CC(C)=Cc1cc(C)cc(N)n1 CHEMBL464556 IC50 685.0 nM
CC(=N)NCCSC[C@@H](N)C(=O)O CHEMBL435854 IC50 700.0 nM
CC1=CCN=C(N)C1 CHEMBL76342 IC50 700.0 nM
CN1CCC(N(C)Cc2cc(Cl)ccc2C(F)(F)F)CC1 CHEMBL258348 IC50 700.0 nM
N=C(N)C1CCCN1 CHEMBL1783092 IC50 700.0 nM
CC(N)(CSCCNC(=N)N)C(=O)O CHEMBL3967477 IC50 700.0 nM
C[C@](N)(CSCCNC(=N)N)C(=O)O CHEMBL3965083 IC50 700.0 nM
NCCC1CCCCC(N)=N1 CHEMBL92475 IC50 701.0 nM
CCOC(=O)N1CCC(Nc2cc(Cl)ccn2)CC1 CHEMBL1221660 IC50 720.0 nM
COc1ccnc(CCc2nc3c(OCCc4ccccc4)ccnc3[nH]2)c1 CHEMBL1800532 pIC50 724.44 nM
NC1=NCCc2ccsc21 CHEMBL268521 IC50 730.0 nM
CCCc1nc2ccccc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801485 EC50 730.0 nM
Cc1cc(N)nc(CC(C)CCF)c1 CHEMBL447472 IC50 731.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)/C=C/c1ccc(Cl)cc1 CHEMBL2289691 IC50 731.0 nM
O=c1cc(Cn2c(C3CCCC3)nc3ccccc32)c2ccc(F)c(F)c2[nH]1 CHEMBL1801488 EC50 750.0 nM
Cc1ncsc1C(=O)N(Cc1cncc2c(F)cccc12)c1cccc(Cl)c1 CHEMBL521778 EC50 760.0 nM
COc1ccc(CNCCCN(C)c2nc(-n3ccnc3)ns2)cc1OC CHEMBL1911888 EC50 760.0 nM
COC(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccc(Cl)c(Cl)c1 CHEMBL5093391 IC50 765.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)/C=C/c1ccc(Cl)c(Cl)c1 CHEMBL5077818 IC50 766.0 nM
O=C(C1CCCC1)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1cccc(Cl)c1 CHEMBL512501 EC50 770.0 nM
COc1ccnc(CCc2nc3c(OC)ccnc3[nH]2)c1 CHEMBL1800530 pIC50 776.25 nM
CCCCC[C@H]1NC(=N)[C@@H](O)[C@H]1C CHEMBL114534 IC50 780.0 nM
COC(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccc(Cl)cc1 CHEMBL2289685 IC50 782.0 nM
Cc1ccnc(NCc2ccccc2)c1 CHEMBL1762482 IC50 790.0 nM
N=C(N)C1CC1 CHEMBL1783071 IC50 790.0 nM
O=c1oc2ccc(Cl)cc2n1CN1CCOCC1 CHEMBL319405 IC50 800.0 nM
CC(C)c1nc2ccccc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801482 EC50 800.0 nM
Cc1cnc(N)cc1C CHEMBL293022 IC50 810.0 nM
CC1CSCCC(N)=N1 CHEMBL364999 IC50 810.0 nM
COC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)/C=C/c1ccccc1Cl CHEMBL5080023 IC50 820.0 nM
c1cn(-c2ccc(Oc3cc(N4CCOCC4)nc(Cc4ccc5c(c4)OCO5)n3)cc2)cn1 CHEMBL244397 IC50 830.0 nM
COC(=O)[C@@H](N)CCCNC(=N)N[N+](=O)[O-] CHEMBL1256014 IC50 830.0 nM
N=C(NCc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1)c1ccccc1 CHEMBL5403837 IC50 832.0 nM
Cc1ncsc1C(=O)N(Cc1cc(=O)oc2c(F)c(F)ccc12)c1cccc(Cl)c1 CHEMBL453401 EC50 840.0 nM
CC(C)c1nc2nccnc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12 CHEMBL1801058 EC50 850.0 nM
C[C@@H]1CC(N)=N[C@@H]2CCCCC[C@H]12 CHEMBL190655 IC50 860.0 nM
CCSC(=N)Nc1ccccc1 CHEMBL545673 Ki 870.0 nM
CCSC(=N)Nc1ccccc1 CHEMBL451666 Ki 870.0 nM
CN(Cc1ccccc1)C(=O)CC1CCCCN1c1ccnc(-n2ccnc2)n1 CHEMBL223005 IC50 885.0 nM
C/C=C/CC1CCCCC(N)=N1 CHEMBL89459 IC50 890.0 nM
COc1cc(/C=C/C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)O)ccc1O CHEMBL5092908 IC50 892.0 nM
CCC1N=C(N)c2ccccc2N1 CHEMBL169840 IC50 900.0 nM
NC1=NCCS1 CHEMBL362148 IC50 900.0 nM
CC(C)[C@](N)(CSCCNC(=N)N)C(=O)O CHEMBL3902409 IC50 900.0 nM
CC[C@H](C)[C@H](NC(=O)/C=C/c1ccc(Cl)cc1)C(=O)OC CHEMBL2289689 IC50 916.0 nM
CCC1CN=C(N)C1C CHEMBL184798 IC50 930.0 nM
Cc1cccnc1N CHEMBL291544 IC50 940.0 nM
COC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)/C=C/c1ccc(Cl)cc1 CHEMBL5078616 IC50 945.0 nM
NC1=Nc2cc(CNCc3cccc(Cl)c3)ccc2[C@H]2CCC[C@@H]12 CHEMBL544514 IC50 950.0 nM
N#Cc1cc(Cl)ccc1O[C@H](CCN)c1ccccc1 CHEMBL1762477 IC50 960.0 nM
CC1CC(N)=Nc2ccccc21 CHEMBL192033 IC50 974.0 nM
NC1=NC(CC[N+](=O)[O-])COCC1 CHEMBL314727 IC50 979.0 nM
COc1cccc(N(Cc2cc(=O)[nH]c3c(F)cccc23)C(=O)c2scnc2C)c1 CHEMBL490919 EC50 990.0 nM
COC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)/C=C/c1ccc(Cl)c(Cl)c1 CHEMBL5090181 IC50 993.0 nM