CC(C)(C)c1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4796694 IC50 0.051 nM
CC(C)c1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4752559 IC50 0.075 nM
CN(C)c1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4784029 IC50 0.19 nM
CN(C)c1cccc(-c2n[nH]c(=O)o2)c1 CHEMBL4757064 IC50 0.19 nM
O=c1[nH]nc(-c2ccc(C3CC3)cc2)o1 CHEMBL4761454 IC50 0.26 nM
O=c1[nH]nc(-c2cccc(C3CC3)c2)o1 CHEMBL4741570 IC50 0.26 nM
CCc1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4787488 IC50 0.27 nM
CC(C)Oc1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4750152 IC50 0.35 nM
O=C(O)c1cc2c(s1)-c1cc(F)cc(Cl)c1CC2 CHEMBL3760062 IC50 0.4 nM
O=c1[nH]nc(-c2ccccc2C(F)(F)F)o1 CHEMBL4747825 IC50 0.43 nM
CCc1cccc(-c2n[nH]c(=O)o2)c1 CHEMBL4757561 IC50 0.45 nM
O=c1[nH]nc(-c2ccc(C(F)(F)F)cc2)o1 CHEMBL4759088 IC50 0.46 nM
O=c1[nH]nc(-c2cccc(C(F)(F)F)c2)o1 CHEMBL2426243 IC50 0.78 nM
Cc1c(C(F)(F)F)sc2ncnc(SCC(=O)O)c12 CHEMBL4642625 IC50 1.0 nM
O=C(O)CSc1ncnc2c(C3CC3)c(Cl)sc12 CHEMBL3774760 IC50 1.0 nM
O=C(CSc1ncnc2c(C3CC3)c(Cl)sc12)N1CCn2cnnc2C1 CHEMBL4637176 IC50 1.1 nM
COc1cccc(-c2n[nH]c(=O)o2)c1 CHEMBL4782633 IC50 1.2 nM
COc1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4776064 IC50 1.4 nM
O=C1CN(C(=O)CSc2ncnc3c(C4CC4)c(Cl)sc23)CN1 CHEMBL4642915 IC50 1.5 nM
CN1CN(C(=O)CSc2ncnc3c(C4CC4)c(Cl)sc23)CC1=O CHEMBL4648963 IC50 1.5 nM
Cc1c(C(F)(F)F)sc2ncnc(SCC(=O)N3CC(=O)N(C)C3)c12 CHEMBL4632439 IC50 1.6 nM
O=c1[nH]nc(-c2ccc(C3CC3)c(C(F)(F)F)c2)o1 CHEMBL4793575 IC50 1.8 nM
O=c1[nH]nc(-c2cccc(Cl)c2)o1 CHEMBL4085008 IC50 1.8 nM
Cc1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4754273 IC50 2.0 nM
Cc1sc2ncnc(SCC(=O)O)c2c1Cl CHEMBL3774528 IC50 2.0 nM
CC(=O)N1CCc2c1ccc(Cl)c2C(F)(F)F CHEMBL5431852 IC50 2.0 nM
CC(=O)N1CCc2c1ccc(Cl)c2Cl CHEMBL5397552 IC50 2.0 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)N(C)C3)c2c1Cl CHEMBL4646043 IC50 2.4 nM
CCN1CN(C(=O)CSc2ncnc3sc(C)c(Cl)c23)CC1=O CHEMBL4637948 IC50 2.6 nM
Cc1sc2ncnc(SCC(=O)N3CNC(=O)C3)c2c1Cl CHEMBL4648770 IC50 2.7 nM
O=c1[nH]nc(-c2ccc(C(F)(F)F)c(C3CC3)c2)o1 CHEMBL4791705 IC50 2.9 nM
Cc1cccc(-c2n[nH]c(=O)o2)c1 CHEMBL4743027 IC50 2.9 nM
O=c1[nH]nc(-c2ccc(C(F)F)cc2)o1 CHEMBL4749659 IC50 3.0 nM
O=c1[nH]nc(-c2cccc(C(F)F)c2)o1 CHEMBL4763193 IC50 3.1 nM
Cc1sc2ncnc(SCC(=O)N3CCn4cnnc4C3)c2c1Cl CHEMBL4641132 IC50 3.2 nM
Cc1c(C(F)(F)F)oc2ncnc(SCC(=O)O)c12 CHEMBL4637227 IC50 3.2 nM
O=c1[nH]nc(-c2ccc(F)cc2)o1 CHEMBL4761164 IC50 3.5 nM
Cc1ccccc1-c1nnc(O)o1 CHEMBL2324854 IC50 3.6 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)N(C4CC4)C3)c2c1Cl CHEMBL4643862 IC50 3.8 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)N(CC(F)(F)F)C3)c2c1Cl CHEMBL4634865 IC50 3.9 nM
Cc1sc2ncnc(SCC(=O)O)c2c1C(F)(F)F CHEMBL4641550 IC50 3.9 nM
Cc1c(C(F)(F)F)oc2ncnc(SCC(=O)N3CC(=O)N(C)C3)c12 CHEMBL4633059 IC50 3.9 nM
O=c1[nH]nc2ccc(Sc3cccc(OC(F)(F)F)c3)nn12 CHEMBL5078659 IC50 4.0 nM
CCN1CCN(C(=O)CSc2ncnc3sc(C)c(Cl)c23)CC1=O CHEMBL4636343 IC50 4.2 nM
[2H]c1nnn(-c2ccc(Cl)c(C(F)(F)F)c2Cl)c1[2H] CHEMBL5206349 IC50 4.6 nM
O=c1[nH]nc2ccc(Sc3ccc(Cl)c(Cl)c3)nn12 CHEMBL5070478 IC50 5.0 nM
Cc1sc2ncnc(SCC(=O)N3CCNC(=O)C3)c2c1Cl CHEMBL4641545 IC50 5.8 nM
Cc1sc2ncnc(SCC(=O)O)c2c1C CHEMBL1689356 IC50 5.8 nM
O=c1[nH]nc2ccc(Sc3cccc(Cl)c3)nn12 CHEMBL5079105 IC50 6.0 nM
Cc1sc2ncnc(SCC(=O)N3CCN(C)C(=O)C3)c2c1Cl CHEMBL4647057 IC50 6.2 nM
CC(C)c1ccc(-c2n[nH]c(=O)o2)cc1C(F)(F)F CHEMBL4794717 IC50 6.2 nM
FC(F)(F)c1c(Cl)ccc(-n2ccnn2)c1Cl CHEMBL5178575 pIC50 6.31 nM
O=c1[nH]nc(-c2ccccc2Cl)o1 CHEMBL4079629 IC50 6.7 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)N(C)C3)c2c1C(F)(F)F CHEMBL4636894 IC50 7.0 nM
Cc1ccc(Sc2ccc3n[nH]c(=O)n3n2)cc1C CHEMBL5077097 IC50 7.0 nM
O=C1CN(C(=O)CSc2ncnc3c(C4CC4)c(Cl)sc23)CCN1 CHEMBL4640648 IC50 7.1 nM
CN(C)C(=O)CSc1ncnc2c(C3CC3)c(Cl)sc12 CHEMBL4646342 IC50 7.5 nM
FC(F)(F)c1c(Cl)cnc(-n2ccnn2)c1Cl CHEMBL5194030 IC50 7.5 nM
Cc1cc(F)c2c(c1F)-c1sc(C(=O)O)cc1CC2 CHEMBL3759074 EC50 8.0 nM
N#Cc1sc2c(SCC(=O)O)ncnc2c1C1CC1 CHEMBL4632898 IC50 8.1 nM
Cc1ccc(/C=C2/N=C(c3ccc(C)c(C)c3)OC2=O)o1 CHEMBL5088670 IC50 8.5 nM
NC(=O)c1cc2c(s1)-c1ccccc1CC2 CHEMBL3759069 EC50 9.0 nM
Cc1cccc(Sc2ccc3n[nH]c(=O)n3n2)c1 CHEMBL5076852 IC50 9.0 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)N(C)C3)c2c1C CHEMBL4632460 IC50 9.4 nM
OCc1cn(-c2ccc(Cl)c(C(F)(F)F)c2Cl)nn1 CHEMBL5173563 IC50 9.5 nM
Cc1nc2n(n1)CCN(C(=O)CSc1ncnc3sc(C)c(Cl)c13)C2 CHEMBL4636249 IC50 11.0 nM
O=c1[nH]nc(-c2ccccc2F)o1 CHEMBL4758707 IC50 11.0 nM
CC(=O)N1CC2(CC2)c2c(Cl)cccc21 CHEMBL5409935 IC50 11.0 nM
O=C(O)CSc1ncnc2c(C3CC3)c(C(F)(F)F)sc12 CHEMBL3774864 EC50 12.0 nM
O=C(CCC(=O)N1CCc2ccccc21)OCC(F)F CHEMBL5072324 IC50 12.0 nM
O=C1OC(c2cccc(Cl)c2Cl)=N/C1=C/c1ccco1 CHEMBL5078105 IC50 12.0 nM
O=C1C2CN(Cc3ccc(Cl)cc3)CCN2C(=O)N1OC(=O)N1CCOc2ccccc21 CHEMBL4174188 IC50 13.0 nM
FC(F)(F)c1cc(-c2nnco2)ccc1Cl CHEMBL4760228 IC50 13.0 nM
O=c1[nH]nc(-c2cccc(F)c2)o1 CHEMBL4786162 IC50 13.0 nM
O=c1[nH]nc2ccc(Sc3cccc(Cl)c3Cl)nn12 CHEMBL5087217 IC50 13.0 nM
O=C1OC(c2ccc(Cl)cc2Cl)=N/C1=C\c1ccco1 CHEMBL5093578 IC50 14.0 nM
Cc1cccc(Sc2ccc3n[nH]c(=O)n3n2)c1C CHEMBL5092159 IC50 14.0 nM
NC(=O)c1cc2c(s1)-c1ccccc1OCC2 CHEMBL3758275 EC50 15.0 nM
CC1(C)Cc2cc(C(N)=O)sc2-c2ccccc21 CHEMBL3758963 EC50 15.0 nM
Cc1sc2ncnc(SCC(=O)N(C)C)c2c1Cl CHEMBL4649597 IC50 15.0 nM
Cc1sc2ncnc(SCC(=O)N3CCn4ncnc4C3)c2c1Cl CHEMBL4642569 IC50 15.0 nM
CN(C)c1ccc(-c2n[nH]c(=O)o2)cc1C(F)(F)F CHEMBL4799989 IC50 15.0 nM
COc1cccc(Sc2ccc3n[nH]c(=O)n3n2)c1 CHEMBL5085330 IC50 15.0 nM
CC1Cc2cc(C(N)=O)sc2-c2ccccc21 CHEMBL3758280 EC50 16.0 nM
Cc1sc2ncnc(SCC(=O)N3CCn4c(C)nnc4C3)c2c1Cl CHEMBL4634165 IC50 16.0 nM
Cc1ccc(/C=C2\N=C(c3ccc(C)c(C)c3)OC2=O)o1 CHEMBL5079572 IC50 17.0 nM
O=c1[nH]nc2ccc(Sc3cccc(C(F)(F)F)c3)nn12 CHEMBL5088818 IC50 17.0 nM
CC(=O)N1CC2(CC2)c2c1cccc2C(F)(F)F CHEMBL5433459 IC50 17.0 nM
O=C(CSc1ncnc2c(C3CC3)c(Cl)sc12)N1CCOCC1 CHEMBL4645675 IC50 18.0 nM
Cc1sc2ncnc(SCC(=O)N3CCn4nc(C(F)(F)F)nc4C3)c2c1Cl CHEMBL4643464 IC50 18.0 nM
O=c1[nH]nc(-c2ccc(Cl)c(C(F)(F)F)c2)o1 CHEMBL4788846 IC50 18.0 nM
O=c1[nH]nc(-c2ccc([N+](=O)[O-])cc2)o1 CHEMBL4745403 IC50 18.0 nM
Clc1ccc(-n2ccnn2)c(Cl)c1Cl CHEMBL5207589 IC50 18.0 nM
NC(=O)c1cc2c(s1)-c1ccccc1CCC2 CHEMBL3759297 EC50 19.0 nM
O=C(O)c1cc2c(s1)-c1cc(F)cc(F)c1SC2 CHEMBL3760048 EC50 20.0 nM
O=C(O)c1cc2c(s1)-c1cc(F)c(F)c(F)c1SC2 CHEMBL3758291 EC50 20.0 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)N4CCCC4C3)c2c1Cl CHEMBL4640262 IC50 20.0 nM
CCOc1cccc(Sc2ccc3n[nH]c(=O)n3n2)c1 CHEMBL5092978 IC50 20.0 nM
O=c1[nH]nc2ccc(Sc3ccc(Cl)cc3Cl)nn12 CHEMBL5088589 IC50 20.0 nM
O=C(O)c1cc2c(s1)-c1ccc(Cl)c(Cl)c1CC2 CHEMBL3758560 EC50 21.0 nM
O=c1[nH]nc2ccc(Sc3ccc(Cl)cc3)nn12 CHEMBL5079298 IC50 21.0 nM
Cc1ccc(/C=C2/N=C(c3cccc(Cl)c3Cl)OC2=O)o1 CHEMBL5071042 IC50 22.0 nM
Cc1cc(F)c2c(c1)-c1sc(C(=O)O)cc1CC2 CHEMBL3759274 EC50 23.0 nM
CCc1nnc2n1CCN(C(=O)CSc1ncnc3sc(C)c(Cl)c13)C2 CHEMBL4639884 IC50 23.0 nM
Cc1ccc(C2=N/C(=C/c3cccs3)C(=O)O2)cc1C CHEMBL5092384 IC50 24.0 nM
CSc1cccc(Sc2ccc3n[nH]c(=O)n3n2)c1 CHEMBL5092063 IC50 24.0 nM
Cc1c(C#N)sc2ncnc(SCC(=O)O)c12 CHEMBL4641272 IC50 25.0 nM
CC(C)Oc1cccc(Sc2ccc3n[nH]c(=O)n3n2)c1 CHEMBL5091552 IC50 25.0 nM
Cc1sc2ncnc(SCC(=O)N3CCn4c(nnc4C4CC4)C3)c2c1Cl CHEMBL4642382 IC50 27.0 nM
N#Cc1ccc(-c2n[nH]c(=O)o2)cc1 CHEMBL4744661 IC50 27.0 nM
Cc1ccc(Sc2ccc3n[nH]c(=O)n3n2)cc1 CHEMBL5079507 IC50 27.0 nM
Cc1ccc(Sc2ccc3n[nH]c(=O)n3n2)c(C)c1 CHEMBL5093068 IC50 27.0 nM
O=c1[nH]nc2ccc(Sc3ccc(C(F)(F)F)cc3)nn12 CHEMBL5069664 IC50 28.0 nM
COc1ccc2c(c1Cl)CCc1cc(C(=O)O)sc1-2 CHEMBL3758668 EC50 30.0 nM
O=c1[nH]nc2ccc(Sc3ccccc3Cl)nn12 CHEMBL5078474 IC50 30.0 nM
O=c1[nH]nc2ccc(Sc3cccc(F)c3)nn12 CHEMBL5075787 IC50 30.0 nM
CC(=O)N1CCc2c1cccc2C(F)(F)F CHEMBL5411107 IC50 30.0 nM
O=c1[nH]nc(-c2ccc(Cl)c(C(F)(F)F)c2)s1 CHEMBL4756992 IC50 31.0 nM
Cc1ccc(-c2n[nH]c(=O)o2)cc1C(F)(F)F CHEMBL4780504 IC50 31.0 nM
O=C(O)c1cn(-c2ccc(Cl)c(C(F)(F)F)c2Cl)nn1 CHEMBL5179683 IC50 31.0 nM
CC(=O)n1ccc2c(Cl)c(Cl)ccc21 CHEMBL5422673 IC50 31.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2cn(C(C)C)nc2c1 CHEMBL4539054 IC50 32.0 nM
CN1CCN(C)c2cc(-c3n[nH]c(=O)o3)ccc21 CHEMBL4762374 IC50 32.0 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)NC(C)C3)c2c1Cl CHEMBL4635221 IC50 33.0 nM
CN1CCc2ccc(-c3n[nH]c(=O)o3)cc21 CHEMBL4789348 IC50 33.0 nM
O=C(O)c1cc2c(s1)-c1cc(Cl)cc(Cl)c1CC2 CHEMBL3760106 EC50 34.0 nM
CC(=O)N1CC2(CC2)c2cc(Cl)ccc21 CHEMBL5434038 IC50 34.0 nM
Cc1cc(F)c2c(c1)-c1sc(C(=O)O)cc1CO2 CHEMBL3759117 EC50 35.0 nM
O=C(O)c1cc2c(s1)-c1cc(F)cc(Cl)c1OC2 CHEMBL3759027 EC50 35.0 nM
Cc1cc(Cl)c2c(c1)-c1sc(C(=O)O)cc1CC2 CHEMBL3759576 EC50 36.0 nM
Cc1sc2ncnc(SCC(=O)N3CCn4c(nnc4C(F)(F)F)C3)c2c1Cl CHEMBL4639527 IC50 38.0 nM
CC1Cc2ccccc2-c2sc(C(N)=O)cc21 CHEMBL3759323 EC50 40.0 nM
CC(=O)N1CCc2c(Cl)cccc21 CHEMBL5397202 IC50 40.0 nM
O=c1[nH]nc(-c2ccccc2)o1 CHEMBL554820 IC50 41.0 nM
O=C(O)c1cc2c(s1)-c1ccc(Cl)c(Cl)c1OC2 CHEMBL3758201 EC50 42.0 nM
Cc1cc(C)cc(Sc2ccc3n[nH]c(=O)n3n2)c1 CHEMBL5082240 IC50 47.0 nM
O=C1OC(c2ccc(Cl)cc2Cl)=N/C1=C/c1ccco1 CHEMBL5084698 IC50 48.0 nM
Cc1oc2ncnc(SCC(=O)O)c2c1C CHEMBL4636078 IC50 50.0 nM
Cc1ccccc1Sc1ccc2n[nH]c(=O)n2n1 CHEMBL5082211 IC50 50.0 nM
O=C1OC(c2cccc(Cl)c2Cl)=N/C1=C/c1cccs1 CHEMBL5091063 IC50 54.0 nM
O=C(O)c1cc2c(s1)-c1cc(F)c(Cl)cc1OC2 CHEMBL3760065 EC50 56.0 nM
O=C(O)c1cc2c(s1)-c1cc(Cl)cc(F)c1OC2 CHEMBL3758326 EC50 59.0 nM
O=C(O)c1cc2c(s1)-c1ccc(F)c(F)c1CC2 CHEMBL3759908 EC50 61.0 nM
CC(=O)N1CC2(CC2)c2ccccc21 CHEMBL5423875 IC50 61.0 nM
Cc1ccc2c(c1C#N)CCc1cc(C(=O)O)sc1-2 CHEMBL3758279 EC50 62.0 nM
O=c1[nH]nc2ccc(Sc3cccc(F)c3F)nn12 CHEMBL5089696 IC50 63.0 nM
O=C(CCC(=O)N1CCc2ccccc21)OCc1ccccc1 CHEMBL5091150 IC50 64.0 nM
OCc1cn(-c2ccc(Cl)c(C(F)(F)F)c2)nn1 CHEMBL5184800 IC50 65.0 nM
O=C(O)c1cc2c(s1)-c1c(cc(F)c(F)c1F)OC2 CHEMBL3759995 EC50 67.0 nM
CCn1cc2ccc(NC(=O)COc3ccccc3C)cc2n1 CHEMBL4446980 IC50 68.0 nM
O=C(COc1ccccc1Cl)Nc1ccc2cnccc2c1 CHEMBL4525905 IC50 69.0 nM
Cc1sc2ncnc(SCC(=O)N3CCOCC3)c2c1Cl CHEMBL4635158 IC50 69.0 nM
N#Cc1c(F)ccc2c1CCc1cc(C(=O)O)sc1-2 CHEMBL3759044 EC50 70.0 nM
Cc1ccc(Sc2cc(C)c3n[nH]c(=O)n3n2)cc1 CHEMBL5094566 IC50 70.0 nM
O=C(O)c1cc2c(s1)-c1ccc(F)c(Cl)c1CC2 CHEMBL3759700 EC50 72.0 nM
N#Cc1cc(F)cc2c1OCc1cc(C(=O)O)sc1-2 CHEMBL3759406 EC50 75.0 nM
O=C1N2c3ccccc3CC2CC1(F)F CHEMBL5413014 IC50 77.0 nM
O=C(O)c1cc2c(s1)-c1c(F)ccc(F)c1SC2 CHEMBL3758520 EC50 80.0 nM
N#Cc1cccc2c1CCc1cc(C(=O)O)sc1-2 CHEMBL3759635 EC50 82.0 nM
CC(=O)N1CCc2c(C)cccc21 CHEMBL5409385 IC50 83.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2cnccc2c1 CHEMBL4441123 IC50 85.0 nM
COc1ccc2c(c1C#N)CCc1cc(C(=O)O)sc1-2 CHEMBL3759035 EC50 87.0 nM
O=c1[nH]nc2ccc(Sc3ccccc3F)nn12 CHEMBL5074459 IC50 87.0 nM
CCCc1sc2ncnc(SCC(=O)O)c2c1Cl CHEMBL3775257 EC50 88.0 nM
O=c1[nH]nc2ccc(Sc3ccccc3C(F)(F)F)nn12 CHEMBL5074993 IC50 89.0 nM
COC(=O)CCC(=O)N1CCc2ccccc21 CHEMBL5084693 IC50 90.0 nM
O=C(CSc1ncnc2c(C3CC3)c(Cl)sc12)N1CCCCC1 CHEMBL4644561 IC50 91.0 nM
CC(=O)N1CCc2c(F)cccc21 CHEMBL5438101 IC50 93.0 nM
O=c1[nH]nc2ccc(Sc3ccc(F)cc3)nn12 CHEMBL5087764 IC50 94.0 nM
CC(=O)N1CCc2cc(Cl)ccc21 CHEMBL5415600 IC50 95.0 nM
O=C1OC(c2cccc3ccccc23)=N/C1=C/c1ccco1 CHEMBL5081501 IC50 100.0 nM
O=C(O)[C@H]1CCN(c2ccc(Cl)c(C(F)(F)F)c2)C1 CHEMBL4637220 IC50 110.0 nM
Cc1cn(-c2ccc(Cl)c(C(F)(F)F)c2Cl)nn1 CHEMBL5194024 IC50 110.0 nM
Cc1sc2c(SCC(=O)O)ncnc2c1C1CC1 CHEMBL3775525 EC50 115.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2nn[nH]c2c1 CHEMBL4439414 IC50 120.0 nM
O=c1[nH]nc2ccc(Sc3ccc(F)c(F)c3)nn12 CHEMBL5077080 IC50 120.0 nM
O=C(O)c1cc2c(s1)-c1ccc(F)c(Cl)c1OC2 CHEMBL3760070 EC50 126.0 nM
O=C(O)c1cc2c(s1)-c1ccccc1S(=O)(=O)C2 CHEMBL3758454 EC50 139.0 nM
FC(F)(F)c1c(Cl)ccc(-n2cnnn2)c1Cl CHEMBL5173180 IC50 140.0 nM
Cc1c(Br)sc2ncnc(SCC(=O)O)c12 CHEMBL3774472 EC50 144.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(C(C)C)c1F CHEMBL4646852 IC50 150.0 nM
O=c1[nH]nc2ccc(Sc3ccccc3)nn12 CHEMBL5080797 IC50 150.0 nM
O=C(O)c1cc2c(s1)-c1cccc(F)c1SC2 CHEMBL3758239 EC50 160.0 nM
Cc1sc2ncnc(SCC(=O)c3c[nH]c(CNS(=O)(=O)C4CC4)c3)c2c1C CHEMBL3775309 EC50 168.0 nM
O=C(O)c1cc2c(s1)-c1cc(Cl)cc(Cl)c1OC2 CHEMBL3758861 EC50 173.0 nM
O=C1CCC2Cc3ccccc3N12 CHEMBL5396367 IC50 180.0 nM
O=C(O)c1cc2c(s1)-c1cccc(F)c1S(=O)(=O)C2 CHEMBL3759129 EC50 183.0 nM
O=C(O)c1cc2c(s1)-c1cc(F)ccc1SC2 CHEMBL3758678 EC50 186.0 nM
CCOC(=O)CCC(=O)N1CCc2ccccc21 CHEMBL5078750 IC50 190.0 nM
COc1ccc(N2CCN(C(=O)ON3C(=O)C4CN(Cc5ccccc5Cl)CCN4C3=O)CC2)cc1 CHEMBL4163486 IC50 200.0 nM
CCn1ncc2ccc(NC(=O)COc3ccccc3C)cc21 CHEMBL4575726 IC50 200.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(C2CC2)c1F CHEMBL4639422 IC50 200.0 nM
O=C(O)C1CCN(c2ccc(Cl)c(C(F)(F)F)c2)C1 CHEMBL4634413 IC50 200.0 nM
Cc1ccc(C2=N/C(=C/c3ccccc3)C(=O)O2)cc1C CHEMBL5086751 IC50 200.0 nM
COCc1cn(-c2ccc(Cl)c(C(F)(F)F)c2Cl)nn1 CHEMBL5172218 IC50 200.0 nM
Cc1sc2ncnc(SCC(=O)O)c2c1Br CHEMBL3775700 EC50 208.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2cc[nH]c2c1 CHEMBL4580274 IC50 210.0 nM
Cc1sc2ncnc(SCC(=O)c3ccc(CNC(=O)C(C)C)o3)c2c1C CHEMBL3775154 EC50 211.0 nM
Cc1sc2ncnc(SCC(=O)N3CCCCC3)c2c1Cl CHEMBL4638233 IC50 220.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(Cl)c1Cl CHEMBL4646972 IC50 220.0 nM
CC(=O)N1CCc2cc(C)ccc21 CHEMBL5401126 IC50 220.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2c(ccn2C)c1 CHEMBL4445799 IC50 240.0 nM
Cc1ccc(Cc2ccc3n[nH]c(=O)n3n2)cc1 CHEMBL5093264 IC50 240.0 nM
Cc1sc2ncnc(SCC(=O)c3ccc(CNC(=O)C4CC4)o3)c2c1C CHEMBL3775791 EC50 249.0 nM
O=C(O)CSc1ncnc2sc(C3CC3)c(Cl)c12 CHEMBL3775931 EC50 250.0 nM
O=C(O)c1cc2c(s1)-c1cc(Cl)ccc1OC2 CHEMBL3758297 EC50 253.0 nM
O=C(C1CCN(c2ccc(Cl)c(C(F)(F)F)c2)C1)N1CC(F)(F)C1 CHEMBL4644041 IC50 260.0 nM
CC(=O)N1CC(C)c2ccccc21 CHEMBL5418816 IC50 260.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2c(cnn2C)c1 CHEMBL4469124 IC50 270.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2nn(C)nc2c1 CHEMBL4445694 IC50 270.0 nM
Cc1cc(C(=O)O)c(C)n1-c1ccc(Cl)c(Cl)c1 CHEMBL4645096 IC50 270.0 nM
Cc1sc2ncnc(SCC(=O)c3c[nH]c(C(=O)N4CCCC4)c3)c2c1C CHEMBL3775182 EC50 280.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2cn(C)nc2c1 CHEMBL4443347 IC50 280.0 nM
O=C(O)[C@@H]1CCN(c2ccc(Cl)c(C(F)(F)F)c2)C1 CHEMBL4632764 IC50 280.0 nM
COc1ccc(N2CCN(C(=O)ON3C(=O)C4CN(Cc5ccc(Cl)cc5)CCN4C3=O)CC2)cc1 CHEMBL4160119 IC50 290.0 nM
CC(=O)N1CCc2c(C3CC3)cccc21 CHEMBL5410067 IC50 290.0 nM
Cc1ccccc1COc1nn2c(=O)c(C)nnc2s1 CHEMBL5078328 IC50 320.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2[nH]ccc2c1 CHEMBL4564710 IC50 330.0 nM
CC(=O)N1CCc2cc(F)ccc21 CHEMBL5417268 IC50 350.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2nn(C)cc2c1 CHEMBL4467530 IC50 360.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(C(C)C)c1 CHEMBL4634749 IC50 360.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(Cl)c1F CHEMBL4636171 IC50 380.0 nM
CN1CCc2cc(-c3n[nH]c(=O)o3)ccc21 CHEMBL4751418 IC50 380.0 nM
CCc1sc2ncnc(SCC(=O)O)c2c1Cl CHEMBL3775492 EC50 393.0 nM
Cc1sc2ncnc(SCC(=O)NC#N)c2c1C CHEMBL3774544 EC50 400.0 nM
CC(=O)N1CCc2ccccc21 CHEMBL3274978 IC50 400.0 nM
O=C(C1CCN(c2ccc(Cl)c(C(F)(F)F)c2)C1)N1CCCC1 CHEMBL4632541 IC50 410.0 nM
O=c1[nH]nc2ccc(Sc3cccc(C(F)(F)F)n3)nn12 CHEMBL5074284 IC50 410.0 nM
Cc1c(Br)sc2c(SCC(=O)O)ncnc12 CHEMBL3775531 EC50 417.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2cccnc2c1 CHEMBL4435276 IC50 430.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(Cl)c1 CHEMBL4645532 IC50 430.0 nM
Cc1cc(C(=O)O)c(C)n1-c1ccc(Cl)cc1Cl CHEMBL4645650 IC50 430.0 nM
O=c1[nH]nc(-c2ccc(Cl)c(Cl)c2)o1 CHEMBL4794683 IC50 430.0 nM
Cc1c(Cl)sc2c(SCC(=O)O)ncnc12 CHEMBL3775413 EC50 435.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2nnn(C)c2c1 CHEMBL4513340 IC50 440.0 nM
COC(=O)CSc1ncnc2sc(C)c(C)c12 CHEMBL3775896 EC50 445.0 nM
Cc1sc2ncnc(SCC(=O)N3CC(=O)NC(C)(C)C3)c2c1Cl CHEMBL4637531 IC50 450.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(C(C)(C)C)c1 CHEMBL4645103 IC50 460.0 nM
O=C(O)c1cc2c(s1)-c1ccccc1SC2 CHEMBL3759068 EC50 461.0 nM
Cc1ccc(-c2nn3c(=O)c(C)nnc3s2)cc1C CHEMBL5086964 IC50 470.0 nM
CC(C)c1sc2ncnc(SCC(=O)O)c2c1Cl CHEMBL3775859 EC50 477.0 nM
O=C1CCc2cc3ccccc3n21 CHEMBL5413010 IC50 490.0 nM
O=C1CCC2Cc3c(Cl)cccc3N12 CHEMBL5419614 IC50 490.0 nM
OCc1cn(-c2ccc(Cl)c(Cl)c2)nn1 CHEMBL1823290 IC50 500.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2c(c1)ncn2C CHEMBL1441260 IC50 520.0 nM
CC(=O)N1CCc2cc(C(F)(F)F)ccc21 CHEMBL5438244 IC50 520.0 nM
Cc1sc2ncnc(SCC(=O)NO)c2c1C CHEMBL3775635 EC50 556.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(C2CC2)c1 CHEMBL4638675 IC50 580.0 nM
O=C(O)C1CCN(c2ccc(Cl)c(Cl)c2Cl)C1 CHEMBL4640525 IC50 600.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cccc(C#N)c1F CHEMBL4646231 IC50 630.0 nM
CCOc1cccc(-n2c(C)cc(C(=O)O)c2C)c1 CHEMBL4639509 IC50 640.0 nM
Cc1cccc(Sc2ccc3n[nH]c(=O)n3n2)n1 CHEMBL5076818 IC50 650.0 nM
O=C(O)c1cc2c(s1)-c1cc(F)ccc1OC2 CHEMBL3759300 EC50 662.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2cncnc2c1 CHEMBL4553417 IC50 670.0 nM
COc1cccc2c1CCN2C(C)=O CHEMBL5418647 IC50 670.0 nM
COc1ccc2c(c1)CCN2C(C)=O CHEMBL5425390 IC50 670.0 nM
COc1ccc(N2CCN(C(=O)ON3C(=O)C4CN(Cc5ccc(Br)cc5)CCN4C3=O)CC2)cc1 CHEMBL4170569 IC50 677.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2nccnc2c1 CHEMBL4465711 IC50 680.0 nM
Cc1ccc(Nc2ccc3n[nH]c(=O)n3n2)cc1 CHEMBL5087478 IC50 690.0 nM
CC(=O)N1CC(=O)c2ccccc21 CHEMBL5429821 IC50 690.0 nM
Cc1ccc(-n2cc(CO)nn2)cc1C CHEMBL5204800 IC50 730.0 nM
CC(=O)n1ccc2c(Cl)cccc21 CHEMBL5415703 IC50 730.0 nM
CNC(=O)CSc1ncnc2sc(C)c(C)c12 CHEMBL3774810 EC50 789.0 nM
Cc1cc2c(SCC(=O)O)ncnc2s1 CHEMBL1689371 IC50 790.0 nM
COc1c(Cl)cccc1-n1c(C)cc(C(=O)O)c1C CHEMBL4632374 IC50 800.0 nM
CCc1sc2ncnc(SCC(=O)O)c2c1C CHEMBL3775731 EC50 835.0 nM
Cc1cc(C(=O)O)c(C)n1-c1cc(Cl)cc(Cl)c1 CHEMBL4641069 IC50 850.0 nM
Cc1sc2ncnc(SCC(N)=O)c2c1C CHEMBL3775000 EC50 857.0 nM
Cc1cc(C(=O)O)c(C)n1-c1ccc(Cl)cc1 CHEMBL4648146 IC50 860.0 nM
Cc1sc2c(SCC(=O)O)ncnc2c1C CHEMBL3774730 EC50 881.0 nM
Cc1c(Cl)sc2ncnc(SCC(=O)O)c12 CHEMBL3774802 EC50 885.0 nM
NCc1cn(-c2ccc(Cl)c(C(F)(F)F)c2Cl)nn1 CHEMBL5187745 IC50 910.0 nM
O=c1[nH]nc(-c2ccc(Cl)cc2)s1 CHEMBL4749309 IC50 940.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2ccncc2c1 CHEMBL4519125 IC50 970.0 nM
Cc1ccccc1OCC(=O)Nc1ccc2ncn(C)c2c1 CHEMBL4531217 IC50 980.0 nM
Cc1ccc(N(C)c2ccc3n[nH]c(=O)n3n2)cc1 CHEMBL5094082 IC50 990.0 nM
O=C(Nc1ccccc1)C1CCN(c2ccc(Cl)c(C(F)(F)F)c2)C1 CHEMBL4643261 IC50 1000.0 nM
OCc1cn(-c2ccc(C(F)(F)F)c(Cl)c2)nn1 CHEMBL5177726 IC50 1000.0 nM
CS(=O)(=O)N1CC2(CC2)c2c(Cl)cccc21 CHEMBL5402980 IC50 1000.0 nM