COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC CHEMBL1350719 Potency 0.1 nM
Cn1ncnc2c(=O)n(C)c(=O)nc1-2 CHEMBL578512 Potency 0.3 nM
CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O CHEMBL230333 pEC50 0.6761 nM
Nc1ncnc2c1ncn2C1CCCO1 CHEMBL64239 Potency 0.8 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1 CHEMBL1474387 IC50 0.96 nM
COc1ccc(/C=N/NC(=S)SC)cc1OC CHEMBL1978331 Potency 1.0 nM
CCC(C)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 CHEMBL1210313 IC50 1.2 nM
O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 CHEMBL469696 pIC50 1.995 nM
CCOC(=O)c1c(N)n(CCOC(=O)c2cccs2)c2nc3ccccc3nc12 CHEMBL1541027 Potency 2.0 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 CHEMBL3086823 IC50 2.2 nM
O=C(CCc1ccc(S(=O)(=O)N2CCOCC2)cc1)OCc1nc2ccccc2s1 CHEMBL1493765 Potency 3.2 nM
Cc1ccc2[nH]c(C(F)OC(F)(F)F)nc2c1 CHEMBL1339217 Potency 3.2 nM
O=S(=O)(c1ccc(OCC(O)CNCc2ccco2)c(Cl)c1)N1CCOCC1 CHEMBL1517046 Potency 3.2 nM
CS(=O)(=O)N1CCN(c2nc3ccccc3s2)CC1 CHEMBL1322287 Potency 3.2 nM
CCCn1c(-c2ccc(OC)cc2)nc2ccccc21 CHEMBL1368940 Potency 3.2 nM
Cc1nnc(SCCC(=O)Nc2nc(-c3ccccc3)ns2)s1 CHEMBL1471358 Potency 3.2 nM
COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 CHEMBL3086836 IC50 3.2 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 CHEMBL3086821 IC50 3.4 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl CHEMBL3086837 IC50 3.4 nM
COc1ccc(O)c(/C=N/Nc2nc(Nc3ccccc3)nc(-n3nc(C)cc3C)n2)c1 CHEMBL3192616 Potency 4.0 nM
N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O CHEMBL1302894 Potency 4.0 nM
COc1ccc2nc(N=C(S)N(C)C)sc2c1 CHEMBL1527869 Potency 4.0 nM
NCCc1nnc(SCc2c(F)cccc2Cl)o1 CHEMBL1400395 Potency 4.0 nM
Cc1cccc(N2CCN(C(=O)C(NS(=O)(=O)c3cccs3)c3ccccc3)CC2)c1C CHEMBL1460146 Potency 4.0 nM
Cc1ccc(CSc2nncn2-c2ccccn2)cc1 CHEMBL1325875 Potency 4.0 nM
Cc1ccc(/C=C(\C#N)c2nc3ccccc3[nH]2)s1 CHEMBL118009 Potency 4.0 nM
CCN(CC)CCCOC(=O)C(OC(C)C)(c1ccccc1)c1ccccc1 CHEMBL1444688 Potency 4.0 nM
COc1ccc2c(c1)c(=O)cc(-c1ccccc1)n2C CHEMBL1415524 Potency 4.0 nM
c1ccc(CCNC2=NCCCS2)cc1 CHEMBL1565191 Potency 4.0 nM
CCC1CN(C)CCC1(OC(C)=O)c1ccccc1 CHEMBL1511656 Potency 4.0 nM
Cn1c(=O)c(/C(=N/c2ccccc2C(C)(C)C)c2nn[nH]n2)c(O)c2ccccc21 CHEMBL3199798 Potency 4.0 nM
Cc1ccc(OC(=O)COc2ccccc2C)c(-n2nc3ccccc3n2)c1 CHEMBL1425537 Potency 4.0 nM
CN(C)c1ccnc(SCc2ccccc2Cl)c1C#N CHEMBL1418483 Potency 4.0 nM
CCOC(=O)c1[nH]c2ccc(OCC)cc2c1NC(=O)CN1CCCC(C)C1 CHEMBL1346371 Potency 4.0 nM
COc1cccc(-c2nnc(-c3ccc(C(F)(F)F)cc3)o2)c1OC CHEMBL1484736 Potency 4.0 nM
C=CCNC(=O)C(C(=O)OCC)C1CCCCC1 CHEMBL1329723 Potency 4.0 nM
CCOC(=O)c1ccc(NC(=O)CSc2nnc(C3CCCCC3)n2C)cc1 CHEMBL1359353 Potency 4.0 nM
O=C(CCc1ccc(Oc2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)cc1)N1CCCCC1 CHEMBL1340021 Potency 4.0 nM
C=CCN1C(=O)CN=C1Nc1cc(C)ccc1C CHEMBL1322060 Potency 4.0 nM
COc1ccc(C2CC(c3ccc(Cl)cc3Cl)Nc3nc(N)nn32)cc1 CHEMBL1343825 Potency 4.0 nM
CC1(C)CC(=O)C=C(NC2CCCCCCC2)C1 CHEMBL1458907 Potency 4.0 nM
CC(C)(C)c1cnnn1-c1ccc(C=O)cc1 CHEMBL1599780 Potency 4.0 nM
Cc1ccc(S(=O)(=O)NCCCCCC(=O)Nc2nccs2)cc1 CHEMBL1347258 Potency 4.0 nM
CCOC(=O)c1c(C)[nH]c(C)c1C(=O)CSc1nnc(-c2ccco2)n1Cc1ccccc1 CHEMBL1544119 Potency 4.0 nM
O=C(CSc1nnc(Cn2nnc3ccccc32)o1)Nc1ccc(Cl)cc1 CHEMBL1351072 Potency 4.0 nM
Clc1ccc(OCc2nn3c(-c4ccco4)nnc3s2)cc1 CHEMBL1380530 Potency 4.0 nM
O=C(c1cc2ccccc2oc1=O)N(Cc1cccs1)Cc1cccs1 CHEMBL1344183 Potency 4.0 nM
c1ccc(-c2nc3c(ccc4ccccc43)[nH]2)nc1 CHEMBL1449173 Potency 4.0 nM
COCCNC(=O)C(C)N1c2cccc3cccc(c23)S1(=O)=O CHEMBL1557073 Potency 4.0 nM
O=C1CC(N2CCN(Cc3ccc4c(c3)OCO4)CC2)C(=O)N1c1ccccc1 CHEMBL1559419 Potency 4.0 nM
CCOC(=O)c1c(N)sc(-c2ccccc2)c1C CHEMBL566136 Potency 4.0 nM
CCOC(=O)N1CCN(CCC(=O)Nc2ccc(OC)cc2OC)CC1 CHEMBL1432024 Potency 4.0 nM
Cc1cccnc1Nc1nc(-c2ccccn2)cs1 CHEMBL528694 Potency 4.5 nM
CN(C)C(=S)SSC(=S)N(C)C CHEMBL120563 Potency 4.5 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 CHEMBL3086824 IC50 4.5 nM
C/C(=N\NC(=S)NCCc1ccccc1)c1ccc(C)cc1 CHEMBL3197369 Potency 5.0 nM
Cc1sc(NC(=O)/C=C/c2ccco2)c(C(=O)OC(C)C)c1C CHEMBL1314094 Potency 5.0 nM
Cn1c(C(=O)NCc2ccccn2)cc2c(=O)n3ccccc3nc21 CHEMBL1575456 Potency 5.0 nM
O=C(NCc1ccc(F)cc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 CHEMBL469695 IC50 5.3 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 CHEMBL3086825 IC50 5.7 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 CHEMBL1472563 IC50 6.2 nM
CC12CCC(C(=O)Nc3ccccc3-n3cccc3)(CC1=O)C2(C)C CHEMBL1598557 Potency 6.3 nM
CCOC(=O)N1CCN(c2nc(-c3ccc(Cl)cc3)cs2)CC1 CHEMBL1550204 Potency 6.3 nM
O=C(Nc1ccccc1)c1ccc(S(=O)(=O)NCC2CCCO2)cc1 CHEMBL1375927 Potency 6.3 nM
Cc1ccc(C(=O)NCCN2CCCC2)cc1 CHEMBL1560441 Potency 6.3 nM
CO/C(O)=C1\C(C)=Nc2nnnn2C1c1cccnc1 CHEMBL1302943 Potency 6.3 nM
N#Cc1ccccc1CSc1nc(N2CCCCC2)nc(N2CCCCC2)n1 CHEMBL1387638 Potency 6.3 nM
Cc1ccc(CN(C(=O)CNC(=O)c2cccs2)C(C(=O)NCC2CCCO2)c2ccccc2)cc1 CHEMBL1583472 Potency 6.3 nM
CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 CHEMBL1210244 IC50 7.0 nM
CC1(C)SC(=S)N(/N=C/c2ccccc2)C1N(O)C(=O)Nc1ccc([N+](=O)[O-])cc1 CHEMBL3196262 Potency 7.9 nM
Cc1[nH]c2c(Br)cccc2c1[C@H]1[C@@H](CC#N)C1(C)C CHEMBL1306030 Potency 7.9 nM
COc1ccc(C(=O)NNC(=O)CN2CCC(n3nnc4cc(C(F)(F)F)ccc43)CC2)cc1 CHEMBL1346772 Potency 7.9 nM
Cn1c(=O)c(=O)n(C)c2cc(S(=O)(=O)CCC(=O)N3CCOCC3)ccc21 CHEMBL1346787 Potency 7.9 nM
CCCCNC(=O)C1CCCN1C(=O)NC1CCCCC1 CHEMBL33095 Potency 7.9 nM
OC1=C2C(=Nc3nc(C(F)(F)F)nn3C2c2ccccc2)CC(c2ccco2)C1 CHEMBL1324817 Potency 7.9 nM
COC(=O)CCN(c1ccccc1)S(=O)(=O)c1ccc(OC)cc1 CHEMBL1509752 Potency 7.9 nM
COc1cccc(CN(C(=O)Cc2c[nH]c3ccccc23)C(C(=O)NC2CCCCC2)c2cccs2)c1 CHEMBL1603078 Potency 7.9 nM
Cc1ccc2cc(C)c3nnc(SCC(=O)N4CCCc5ccccc54)n3c2c1C CHEMBL1584139 Potency 7.9 nM
COc1ccc2c(CN(C)c3ccccc3)cc(=O)oc2c1 CHEMBL1352632 Potency 7.9 nM
Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 CHEMBL3086822 IC50 9.0 nM
Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 CHEMBL1514777 IC50 9.1 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 CHEMBL3086838 IC50 9.2 nM
O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 CHEMBL1290004 pIC50 10.0 nM
CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1385840 Potency 10.0 nM
CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 CHEMBL1320806 Potency 10.0 nM
Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F CHEMBL1589089 Potency 10.0 nM
COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 CHEMBL1550682 Potency 10.0 nM
COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 CHEMBL1349430 Potency 10.0 nM
COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 CHEMBL1610905 Potency 10.0 nM
CC(=N\O)/C(CN(C)C)=N/O CHEMBL3210731 Potency 10.0 nM
Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 CHEMBL1299616 Potency 10.0 nM
O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 CHEMBL1480317 Potency 10.0 nM
CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 CHEMBL1469355 Potency 10.0 nM
CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 CHEMBL1547978 Potency 10.0 nM
O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 CHEMBL1522550 Potency 10.0 nM
CCc1ccc(CNCc2cccnc2)cc1 CHEMBL1347786 Potency 10.0 nM
Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 CHEMBL1367658 Potency 10.0 nM
O=C(CSc1cccc[n+]1[O-])Nc1ccccc1Oc1ccccc1 CHEMBL1571839 Potency 12.6 nM
CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccc(I)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O CHEMBL574181 Potency 12.6 nM
COC(=O)c1sccc1NC(=O)Nc1ccc(Cl)c(Cl)c1 CHEMBL76144 Potency 12.6 nM
CC(C)C(=O)Nc1ccc(C(=O)c2ccccc2)cc1 CHEMBL1400927 Potency 12.6 nM
CC1Cc2ccccc2N1C(=O)CSc1nnc(Cc2ccccc2)n1CCc1ccccc1 CHEMBL1527041 Potency 12.6 nM
c1ccc(-n2cnc3cc(NCc4ccncc4)ccc32)cc1 CHEMBL1484885 Potency 12.6 nM
Nn1c(SCC(=O)NC2CCCCC2)nnc1C1CC1 CHEMBL1327371 Potency 12.6 nM
Cc1sc2nc(SCc3nnc(-c4cccs4)o3)n(C3CCCC3)c(=O)c2c1C CHEMBL1558891 Potency 12.6 nM
CC(Oc1ccc(Cl)cc1Cl)c1nc(-c2ccc(NC(=O)c3ccncc3)cc2)no1 CHEMBL1538267 Potency 12.6 nM
COc1ccccc1-c1nc(C#N)c(N2CCC(Cc3ccccc3)CC2)o1 CHEMBL1427602 Potency 12.6 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 CHEMBL3086834 IC50 13.0 nM
CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 CHEMBL1210311 IC50 14.0 nM
CC(C)(C)C1C/C(=C/c2ccccn2)C(=O)/C(=C/c2ccccn2)C1 CHEMBL1541339 Potency 14.1 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 CHEMBL1553073 IC50 15.0 nM
CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)c3ccc[nH]3)[C@H](C)C[C@H]4C)nc2c1C(=O)O CHEMBL1256686 Potency 15.8 nM
Cc1ccc(OCc2nc(-c3ccccn3)no2)c(Br)c1 CHEMBL1454247 Potency 15.8 nM
COc1ccc2cc(CN(CCCN3CCOCC3)Cc3nnnn3C3CCCCC3)c(O)nc2c1 CHEMBL1338864 Potency 15.8 nM
Cc1cccc(NC(=O)Cc2noc3ccccc23)c1 CHEMBL1546726 Potency 15.8 nM
COc1ccc(NC(=O)C2CCN(c3nc(C)cc(C)n3)CC2)cc1 CHEMBL1547121 Potency 15.8 nM
CN1CCN(c2nc(-c3ccccc3)c3cc(Cl)ccc3n2)CC1 CHEMBL1359258 Potency 15.8 nM
O=C(CCC1CCCCC1)NNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL1458442 Potency 15.8 nM
CCc1nnc(NC(=O)c2cnccn2)s1 CHEMBL1609921 Potency 15.8 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 CHEMBL1315807 IC50 16.0 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 CHEMBL3086833 IC50 16.0 nM
CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 CHEMBL1210177 IC50 18.0 nM
O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 CHEMBL1289677 pIC50 19.95 nM
O=C1Nc2c(c(=O)[nH]c(=O)n2-c2ccccc2F)C(C(F)(F)F)(C(F)(F)F)N1 CHEMBL1559621 Potency 20.0 nM
NC(=O)C1CCN(c2nc(C3CC3)nc3c2nnn3Cc2ccccc2Cl)CC1 CHEMBL1581012 Potency 20.0 nM
CCOc1ccccc1CNC(=O)Cn1c(=O)oc2ccccc21 CHEMBL1442225 Potency 20.0 nM
O=C(Oc1cccnc1)c1cccc(Cl)c1 CHEMBL1523235 Potency 20.0 nM
COc1ccc(N2C(=O)CCC(C(=O)Nc3cccc(C)n3)C2c2ccc(OC)c(OC)c2)cc1 CHEMBL1489419 Potency 20.0 nM
CCCC(CCC)C(=O)[O-] CHEMBL433 Potency 20.0 nM
CC(NC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCCC3)c1ccccc1 CHEMBL1487758 Potency 20.0 nM
COC(=O)c1cc(NC(=O)Nc2ccccc2OC)cc(C(=O)OC)c1 CHEMBL1457681 Potency 20.0 nM
Cc1ccccc1C(OCCN(C)C)c1ccccc1 CHEMBL1201023 Potency 20.0 nM
CC(C)CCNC(=O)C12CN(Cc3ccccc3)CC1C(c1ccc([N+](=O)[O-])cc1)=NO2 CHEMBL1302784 Potency 20.0 nM
Cc1ccccc1Cn1ccc(NC(=O)c2cnn3cccnc23)n1 CHEMBL1567867 Potency 20.0 nM
COc1cccc(NC(=O)CCN2CCC(C(N)=O)CC2)c1 CHEMBL1500983 Potency 20.0 nM
CC(=O)N1CCC2(CC1)C(C#N)=C(N)Oc1[nH]nc(C(F)(F)F)c12 CHEMBL1319638 Potency 20.0 nM
CC1=CCC(C(=O)O)(C(=O)N/N=C/c2cccs2)C(c2ccccc2)C1 CHEMBL3209819 Potency 20.0 nM
O=C(Nc1ccccc1)c1ccc(-c2ccc(Br)cc2)o1 CHEMBL1611765 Potency 20.0 nM
Cc1ccc(C)c(N(CC(=O)N/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)S(=O)(=O)c2ccccc2)c1 CHEMBL3194756 Potency 20.0 nM
COCCNC(=O)C(c1cccs1)N(C(=O)Cn1nnc2ccccc21)c1ccc(OC)cc1 CHEMBL1402364 Potency 20.0 nM
COc1cccc(N2CC(C(=O)Nc3c(C)cccc3C)CC2=O)c1 CHEMBL1485845 Potency 20.0 nM
CCCN1/C(=C2/SC(=S)N(CC)C2=O)C=Cc2ccccc21 CHEMBL1573799 Potency 20.0 nM
Cc1ccccc1-n1nnnc1SCc1ncc(-c2ccccc2)o1 CHEMBL1495740 Potency 20.0 nM
COC(=O)c1[nH]c2ccc(C)cc2c1NC(=O)CN1CCCc2ccccc21 CHEMBL1549732 Potency 20.0 nM
CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 CHEMBL1210312 IC50 22.0 nM
COC(=O)/C(=C1/Oc2cc(C)oc(=O)c2S1)C(F)(F)F CHEMBL1492922 Potency 22.4 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 CHEMBL3086826 IC50 23.0 nM
CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)([O-])O[C@H]2[C@H]1OC(=O)CCC CHEMBL1522836 Potency 25.1 nM
O=C1OC(c2ccccc2)(c2ccccc2)N2CCN(C(=O)NCc3ccc(F)cc3)CC12 CHEMBL1368548 Potency 25.1 nM
CN(C)c1nc(N)nc(-c2cccnc2)n1 CHEMBL1301768 Potency 25.1 nM
CC(C)CCNC(=O)C(c1ccco1)N(CC1CCCO1)C(=O)Cn1nnc2ccccc21 CHEMBL1323436 Potency 25.1 nM
CCCOC(=O)c1ccc(Oc2c(C)n[nH]c2-c2ccc(OCC)cc2O)cc1 CHEMBL1428417 Potency 25.1 nM
CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 CHEMBL1256998 Potency 25.1 nM
Cc1c(O)cc2n(c1=O)-c1ccccc1C2(C)C CHEMBL1572075 Potency 25.1 nM
Cc1ccccc1OCC(=O)Nc1cccc2nsnc12 CHEMBL1481841 Potency 25.1 nM
Cc1ccc(C2CC(C(F)F)n3ncc(C(=O)Nc4c(C)nn(Cc5c(F)cccc5Cl)c4C)c3N2)cc1 CHEMBL1349510 Potency 25.1 nM
COc1ccc(OC)c(C2C3=C(N=C4SCC(=O)N42)c2ccccc2CC3)c1 CHEMBL1526433 Potency 25.1 nM
CCn1c(C(=O)N2CCc3ccccc3C2)cc2sccc21 CHEMBL1302713 Potency 25.1 nM
CN(C(=O)COC(=O)c1ccccc1Nc1ccccc1)C1CCS(=O)(=O)C1 CHEMBL1425582 Potency 25.1 nM
CCn1c2ccccc2c2cc(CN3CCN(C(=O)c4ccco4)CC3)ccc21 CHEMBL1339050 Potency 25.1 nM
O=C(Nc1ccccc1)C1CCCN(S(=O)(=O)c2ccc(-n3cnnn3)cc2)C1 CHEMBL1523889 Potency 25.1 nM
Oc1ccc(NCc2ccccc2OCc2ccccc2F)cc1 CHEMBL1084441 Potency 25.1 nM
O=C(Oc1ccc(N(Cc2cccs2)C2=NS(=O)(=O)c3ccccc32)cc1)c1ccc(Cl)cc1 CHEMBL1458249 Potency 25.1 nM
Cc1nc(C)c(C(=O)N(c2ccc(C)c(C)c2)C(C(=O)NCc2ccco2)c2ccccc2)s1 CHEMBL1504342 Potency 25.1 nM
Cc1ccc(Oc2cc(C)nc(-c3ccccc3O)n2)cc1 CHEMBL1389856 Potency 25.1 nM
O=C(O)CC(NC(=O)c1sc2ccccc2c1Cl)c1ccc(F)cc1 CHEMBL1575774 Potency 25.1 nM
CCCc1cc(O)nc(SCC(=O)CSc2nc(O)cc(CCC)n2)n1 CHEMBL1492130 Potency 25.1 nM
CCN(CC)c1ccc(NC(=O)c2c(OC)cccc2OC)c(C)c1 CHEMBL1547699 Potency 25.1 nM
Cn1c(Cl)c(/C=N/OC(=O)c2ccccc2Cl)c2ccccc21 CHEMBL3212772 Potency 25.1 nM
CCCNC(=O)c1[nH]c(C)c(C(C)=O)c1C CHEMBL1324825 Potency 25.1 nM
O=C(Nc1ccc(OC(F)F)c(Cl)c1)[C@@H]1CCCN1C(=O)c1cccs1 CHEMBL1567039 Potency 25.1 nM
O=S(=O)(c1ccccc1)c1cccc(S(=O)(=O)N2CCCCC2)c1 CHEMBL1544612 Potency 25.1 nM
CN(Cc1cccs1)C(=O)Cc1c[nH]c2ccccc12 CHEMBL1583545 Potency 25.1 nM
COc1ccc(CC(=O)N2CC3(C)CC2CC(C)(C)C3)cc1OC CHEMBL1561913 Potency 25.1 nM
Cc1csc(SCCn2c(N3CCN(c4ccccc4)CC3)nc3c2c(=O)[nH]c(=O)n3C)n1 CHEMBL1509993 Potency 25.1 nM
O=C1CCOc2cc(OCc3ccccc3)ccc21 CHEMBL1348198 Potency 25.1 nM
COn1c(SCC(N)=O)nc2ccccc2c1=O CHEMBL1535012 Potency 25.1 nM
O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 CHEMBL3086828 IC50 27.0 nM
CC1C(c2ccccc2)N(C)C(c2ccccc2)CC1(O)c1ccccc1 CHEMBL1446949 Potency 28.2 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C CHEMBL1598051 IC50 30.0 nM
Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 CHEMBL1210242 IC50 31.0 nM
CCc1cccc(C)c1N=C(S)N1CCCC1C(=O)O CHEMBL1572063 Potency 31.6 nM
N=C(N)SCCc1c[nH]cn1 CHEMBL1490875 Potency 31.6 nM
CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)nc2n(CCC)c1=O CHEMBL273807 Potency 31.6 nM
CC(C)Cn1cnc2c1c(=O)n(CC(O)c1ccccc1)c(=O)n2CC(C)C CHEMBL1585904 Potency 31.6 nM
NCC(CP(=O)(O)O)c1ccc(Cl)cc1 CHEMBL1255941 Potency 31.6 nM
COCCNC(=O)c1nc(O)c2nnn(Cc3cc(C)ccc3C)c2n1 CHEMBL1446149 Potency 31.6 nM
CC1(C(=O)O)CCC(C(=O)N2CCOCC2)C1(C)C CHEMBL1483188 Potency 31.6 nM
Cc1c(/N=C/c2cccnc2)c(=O)n(-c2ccccc2)n1C CHEMBL3210056 Potency 31.6 nM
Cc1cccc(-n2c(C)cc(C=C3C(=O)c4ccccc4C3=O)c2C)c1 CHEMBL1567874 Potency 31.6 nM
c1coc(CN=C2N=C(NCc3ccco3)c3ccccc32)c1 CHEMBL1577290 Potency 31.6 nM
O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 CHEMBL1289571 pIC50 31.62 nM
Cn1cccc1Cc1nnc(SCC(=O)N2CCCC2)n1CCc1ccccc1 CHEMBL1345370 Potency 39.8 nM
Cc1sc2nc(SCC(=O)NCCOCCO)n(C)c(=O)c2c1C CHEMBL1510653 Potency 39.8 nM
Cc1ccc(-c2cc(-c3ccccc3C)[nH]n2)c(O)c1 CHEMBL1463825 Potency 39.8 nM
Cn1c(COc2ccc(Cl)cc2)nnc1SCc1ncc(-c2ccccc2)o1 CHEMBL1412804 Potency 39.8 nM
CCOC(=O)C1=C(C)N=c2s/c(=C/c3ccco3)c(=O)n2C1c1cccc(OC)c1 CHEMBL3191913 Potency 39.8 nM
Cc1occc1-c1nnc(SCC(=O)c2c(N)n(Cc3ccccc3)c(=O)n(C)c2=O)n1C CHEMBL1489862 Potency 39.8 nM
O=C(Nc1cccc(Br)c1)c1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1 CHEMBL1347274 Potency 39.8 nM
CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2c(OC)cccc2-c2nccn21 CHEMBL1801361 IC50 43.0 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 CHEMBL3086827 IC50 45.0 nM
COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 CHEMBL1801359 IC50 46.0 nM
COc1ccc2c(c1)C(CCC(=O)N1[C@H](C)CC[C@@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 CHEMBL1801360 IC50 50.0 nM
COCCc1ccc(OCC(O)CNC(C)C)cc1 CHEMBL2062335 Potency 50.1 nM
CN(C)/C=N/c1c(C(=O)NCc2ccccc2)nnn1Cc1ccccc1 CHEMBL3211333 Potency 50.1 nM
COC(=O)c1c(C)[nH]c(C(=O)/C=C/c2ccccc2)c1C CHEMBL1570567 Potency 50.1 nM
Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1 CHEMBL1200450 Potency 50.1 nM
CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1 CHEMBL1256675 Potency 50.1 nM
COCCN(CCOC)S(=O)(=O)c1ccc(C(=O)Nc2nnc(C3CC3)o2)cc1 CHEMBL1384487 Potency 50.1 nM
CC(Sc1nc(-c2ccccc2)cc(C(F)(F)F)n1)C(=O)N1CCOCC1 CHEMBL1541608 Potency 50.1 nM
Cc1ccc(NC(=O)NC(=O)COc2ccc(Cl)cc2Cl)c(C)c1 CHEMBL1424540 Potency 50.1 nM
Cc1ccc(C(=O)NCc2nnc(SCC(=O)Nc3sc4c(c3C#N)CCCC4)n2C)cc1 CHEMBL1388395 Potency 50.1 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 CHEMBL1433323 Potency 55.2 nM
COCCCn1c(-c2ccc(S(=O)(=O)N3CCOCC3)cc2)cs/c1=N/c1ccccc1 CHEMBL3192760 Potency 63.1 nM
COc1ccc(Cc2c(C)nc(N)nc2Cl)cc1 CHEMBL1468548 Potency 63.1 nM
O=C1CCCC(O)=C1C1C2=C(CCCC2=O)Oc2ccccc21 CHEMBL512090 Potency 63.1 nM
COc1cc2c(cc1OC)CN(CC(=O)Nc1ccc(C)cc1)CC2 CHEMBL1597198 Potency 63.1 nM
Cc1ccccc1NC(=O)c1ccc(Nc2c([N+](=O)[O-])cc([N+](=O)[O-])c3ccccc23)cc1 CHEMBL1462003 Potency 63.1 nM
Cc1ccc(S(=O)(=O)NCCCNC(=O)c2ccccc2)cc1 CHEMBL1444068 Potency 63.1 nM
CCOC(=O)c1c(/N=C/c2cccc(C)c2O)sc2c1CCN(C)C2 CHEMBL3212872 Potency 63.1 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 CHEMBL3086820 IC50 64.0 nM
COc1ccc(S(=O)(=O)CCC(=O)O)cc1 CHEMBL1338172 Potency 79.4 nM
CC1(C)CC(=O)C2(CC3=C(CC(C)(C)CC3=O)O2)C(=O)C1 CHEMBL1598489 Potency 79.4 nM
COc1ccc(Nc2nnc(Cc3ccc(Cl)cc3)c(O)n2)c(OC)c1 CHEMBL1449600 Potency 79.4 nM
CCC1Oc2ccc(C)cc2N(Cc2cccc(C)c2)C1=O CHEMBL1363446 Potency 79.4 nM
Cc1sc2nc3n(c(=O)c2c1C)Cc1ccccc1-3 CHEMBL1503485 Potency 79.4 nM
Nc1c(S(=O)(=O)[O-])cc(Nc2ccc(Nc3nc(Cl)nc(Nc4ccc(S(=O)(=O)[O-])cc4)n3)c(S(=O)(=O)[O-])c2)c2c1C(=O)c1ccccc1C2=O CHEMBL1365553 Potency 79.4 nM
Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 CHEMBL960 Potency 79.4 nM
COC(=O)CN(c1ccc(F)cc1)S(=O)(=O)c1ccc2c(c1)OCCO2 CHEMBL1408755 Potency 79.4 nM
Cc1cc(C)c(S(=O)(=O)n2ccc3ccccc32)c(C)c1 CHEMBL1500419 Potency 79.4 nM
Cc1cccc(C)c1OCCCCc1c(C)n[nH]c1C CHEMBL1599021 Potency 79.4 nM
COC(=O)c1ccccc1NC(=O)Cn1ccnc1 CHEMBL1484640 Potency 79.4 nM
CC(C)Sc1nnc([C@@H](N)Cc2c[nH]c3ccccc23)o1 CHEMBL1458152 Potency 79.4 nM
O=C(/C=C/c1ccco1)Nc1ccccn1 CHEMBL1507757 Potency 79.4 nM
CCC(C)NC(=O)c1ccccc1NC(=O)c1ccc(CSc2ccccc2)cc1 CHEMBL1527154 Potency 79.4 nM
O=C1NC(=S)N(C2CC2)C(=O)/C1=C/NNC(=O)c1ccccc1O CHEMBL1359525 Potency 79.4 nM
Cc1cccc(N2CCN(C(=O)C(C)n3nc(C)n4c(cc5occc54)c3=O)CC2)c1C CHEMBL1495181 Potency 79.4 nM
CC1(C)C(=O)Nc2ccccc2N1C(=O)COc1ncnc2ccccc12 CHEMBL1478340 Potency 79.4 nM
CNCCC=C1c2ccccc2CCc2ccccc21 CHEMBL1201156 Potency 79.4 nM
COc1ccc([N+](=O)[O-])cc1NC(=O)CSCc1ccccc1C CHEMBL1377791 Potency 79.4 nM
COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 CHEMBL1801358 IC50 82.0 nM
C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@]43C)[C@H]12 CHEMBL1566610 Potency 89.1 nM
CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 CHEMBL1801337 IC50 90.0 nM
Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801272 IC50 92.0 nM
C[C@@H]1CC[C@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 CHEMBL1801336 IC50 92.0 nM
O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 CHEMBL1801335 IC50 95.0 nM
CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C CHEMBL1801332 IC50 96.0 nM
Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 CHEMBL1506451 Potency 100.0 nM
CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O CHEMBL1578105 Potency 100.0 nM
CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 CHEMBL1613111 Potency 100.0 nM
CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C CHEMBL1338647 Potency 100.0 nM
Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 CHEMBL1570008 Potency 100.0 nM
CN1CCN(CC#CC2(O)CCCCC2)CC1 CHEMBL1404160 Potency 100.0 nM
CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 CHEMBL1340098 Potency 100.0 nM
N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 CHEMBL1327226 Potency 100.0 nM
COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC CHEMBL3213983 Potency 100.0 nM
c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 CHEMBL1387307 Potency 100.0 nM
Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 CHEMBL1387210 Potency 100.0 nM
O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 CHEMBL1602433 Potency 100.0 nM
COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC CHEMBL1587194 Potency 100.0 nM
Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 CHEMBL1430872 Potency 100.0 nM
COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC CHEMBL1517669 Potency 100.0 nM
O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 CHEMBL1337599 Potency 100.0 nM
Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br CHEMBL1307695 Potency 100.0 nM
CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 CHEMBL1609794 Potency 100.0 nM
CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 CHEMBL1402832 Potency 100.0 nM
CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 CHEMBL1580484 Potency 100.0 nM
NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 CHEMBL1335567 Potency 100.0 nM
CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 CHEMBL1466877 Potency 100.0 nM
CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 CHEMBL1210411 IC50 103.0 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 CHEMBL3086835 IC50 110.0 nM
N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801330 IC50 114.0 nM
CN(C)S(=O)(=O)Nc1ccccc1C(N)=O CHEMBL1543597 Potency 125.9 nM
CC(C)(C)n1nnnc1C(c1cccnc1)N1CCN(C(=O)c2ccco2)CC1 CHEMBL1325821 Potency 125.9 nM
Cc1cnc(C)c(N2CCC(C(=O)NC(C)c3cccs3)CC2)n1 CHEMBL1320980 Potency 125.9 nM
Cn1nc(-c2ccccc2F)c2cc(C(=O)Nc3ccc4c(c3)OCCO4)sc21 CHEMBL1335734 Potency 125.9 nM
Cc1ccc(-c2nc(-c3cccnc3)no2)cc1 CHEMBL1489045 Potency 125.9 nM
O=C(OCc1nnc(-c2ccccc2)o1)c1ccco1 CHEMBL1467447 Potency 125.9 nM
CCN(CC)c1nc(Nc2ccc(Cl)cc2)nc(OCC#N)n1 CHEMBL1328553 Potency 125.9 nM
O=C(c1cc(C2CC2)on1)N1CCN(c2ccccc2)CC1 CHEMBL1361036 Potency 125.9 nM
COc1ccccc1NS(=O)(=O)c1ccc(C(=O)OCC(=O)NCc2ccco2)cc1 CHEMBL1382266 Potency 125.9 nM
CN(C)CCNc1ccc(Cl)cc1[N+](=O)[O-] CHEMBL1500490 Potency 125.9 nM
Nc1c(C(=O)NCc2ccco2)c2nc3ccccc3nc2n1CCN1CCCCC1 CHEMBL1403575 Potency 125.9 nM
O=C(CSc1ccc2c(c1)OCCO2)NCc1ccco1 CHEMBL1464418 Potency 125.9 nM
O=C(O)c1sccc1S(=O)(=O)c1ccccc1 CHEMBL1543132 Potency 125.9 nM
COc1ccc2nc(C)cc(N3CC(C)OC(C)C3)c2c1 CHEMBL1452252 Potency 125.9 nM
CCCCC(c1nnnn1C1CCCC1)N1CCN(C2CCCC2)CC1 CHEMBL1416250 Potency 125.9 nM
N#CCN1CCC/C1=C\[N+](=O)[O-] CHEMBL1340003 Potency 125.9 nM
COc1ccc(-c2nn3c(-c4ccccc4)nnc3s2)cc1 CHEMBL1399289 Potency 125.9 nM
Brc1cccc(C2CC(c3ccccc3)n3nnnc3N2)c1 CHEMBL1401692 Potency 125.9 nM
FC(F)(F)c1nc2ccccc2nc1N/N=C/c1c(Cl)cccc1Cl CHEMBL3212695 Potency 125.9 nM
CCCN(CC(=O)c1cc(C)n(C)c1C)S(=O)(=O)c1cccc(C(F)(F)F)c1 CHEMBL1540358 Potency 125.9 nM
Cc1cccc(-c2nnc(SCc3cc(O)nc4ccccc34)n2C)c1 CHEMBL1452753 Potency 125.9 nM
O=C(CSc1nc2ccccc2c(=O)n1Cc1ccco1)N1CCCCCC1 CHEMBL1595175 Potency 125.9 nM
O=C(CCS(=O)(=O)c1ccc(Cl)cc1)N1CCN(S(=O)(=O)c2cccs2)CC1 CHEMBL1599855 Potency 125.9 nM
O=[N+]([O-])c1ccc(NN=C(S)Nc2ccccc2)cc1 CHEMBL1423596 Potency 125.9 nM
O=C(CSc1nc2ccccc2[nH]1)c1ccc2c(c1)OCO2 CHEMBL1463027 Potency 125.9 nM
COc1cc([C@@H]2c3cc4c(cc3[C@H](O)C3COC(=O)[C@@H]32)OCO4)cc(OC)c1OC CHEMBL273648 Potency 125.9 nM
CCOC(=O)N1CCN(C(=O)c2ccc(NC(=O)c3ccc(C)cc3)cc2)CC1 CHEMBL1312136 Potency 125.9 nM
FC(F)(F)c1cc(N2CCOCC2)nc(-c2ccccc2)n1 CHEMBL1463221 Potency 125.9 nM
COc1ccc2c(c1)C(=NN)c1cc(OC)ccc1-2 CHEMBL1483608 Potency 125.9 nM
Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)CC(C)C)cc2)n1 CHEMBL1405243 Potency 125.9 nM
CC(C)n1cnc2cc(NCc3ccccn3)ccc21 CHEMBL1471162 Potency 125.9 nM
CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 CHEMBL1801333 IC50 126.0 nM
CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 CHEMBL1801331 IC50 131.0 nM
Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801327 IC50 134.0 nM
CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C CHEMBL1801334 IC50 138.0 nM
CC1(C)Cc2nc3sc4c(SCC(=O)NC(c5ccccc5)c5ccccc5)ncnc4c3cc2CO1 CHEMBL1301335 Potency 141.3 nM
Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 CHEMBL1210243 IC50 144.0 nM
N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801329 IC50 145.0 nM
Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801317 IC50 154.0 nM
C[N+]1=C2C=CC=CC=C2SC12C([N+](=O)[O-])=CC(=[N+]([O-])[O-])C=C2[N+](=O)[O-] CHEMBL1456412 Potency 158.5 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 CHEMBL50 Potency 158.5 nM
CN(C)S(=O)(=O)c1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCCC3)C(=O)N2 CHEMBL605003 Potency 158.5 nM
COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1 CHEMBL344127 Potency 158.5 nM
CCOc1ccc(C2=Nn3c(nnc3-c3ccccc3OC)SC2)cc1 CHEMBL1342336 Potency 158.5 nM
CCc1cccc(CC)c1N(COC)C(=O)Cn1c(CO)nc2ccccc21 CHEMBL1382254 Potency 158.5 nM
CN1CC(=O)N(CC(=O)Nc2ccc(N(C)C)cc2)c2ccccc2C1=O CHEMBL1506936 Potency 158.5 nM
O=C(/C=C/c1ccccc1)c1cc(Br)ccc(=O)c1O CHEMBL1418885 Potency 158.5 nM
COc1cc2c(cc1OC)CN(C(=O)C1(c3ccccc3)CC1)CC2 CHEMBL1386079 Potency 158.5 nM
O=C1c2ccccc2C(Nc2ccccc2)N1c1ccc(Cl)cn1 CHEMBL1484873 Potency 158.5 nM
O=C(Nc1cccc2cccnc12)c1cccc(N2C(=O)CCC2=O)c1 CHEMBL1485856 Potency 158.5 nM
Cc1ccc(CCC(=O)Nc2ncc(Cc3cccc(Cl)c3Cl)s2)o1 CHEMBL1545099 Potency 158.5 nM
COc1ccc(CCNC(=O)CCn2c(SCC#N)nc3ccccc3c2=O)cc1OC CHEMBL1312534 Potency 158.5 nM
Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 CHEMBL1801267 IC50 163.0 nM
S=C(Nc1ccccn1)c1ccccn1 CHEMBL112597 Potency 177.8 nM
COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC CHEMBL3085788 IC50 190.0 nM
CCOc1ccccc1NC1=CC(=O)CC(c2ccccc2)C1 CHEMBL2002150 Potency 199.5 nM
CC(=O)c1sc(C(C)(C)C)cc1NC(=O)c1ccccc1C(=O)O CHEMBL1162415 Potency 199.5 nM
CC(C)/N=C1\SCC(C)(/C=N/O)S1 CHEMBL3211874 Potency 199.5 nM
CCCCC(=O)NNC(=S)NC(=O)CCC CHEMBL1326171 Potency 199.5 nM
CCC(C)(C)NC(=O)C(c1ccc(C)cc1)N(Cc1cccnc1)C(=O)c1csnn1 CHEMBL1313700 Potency 199.5 nM
CCOc1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21 CHEMBL1302584 Potency 199.5 nM
CCC(C)N(C)C(=O)c1cc2ccccc2c(-c2ccccc2Cl)n1 CHEMBL481537 Potency 199.5 nM
O=C(NC1CC1)c1nc(O)c2nnn(Cc3ccccc3Cl)c2n1 CHEMBL1487615 Potency 199.5 nM
Cc1ccc(NC(=O)CC2SC3=NCCN3C2=O)cc1 CHEMBL1369885 Potency 199.5 nM
Cc1cccc2sc(N(CCCN(C)C)C(=O)c3sc4ccccc4c3Cl)nc12 CHEMBL1423057 Potency 199.5 nM
O=C(NC(=S)Nc1ccc(N2CCOCC2)c(Cl)c1)C(c1ccccc1)c1ccccc1 CHEMBL1573036 Potency 199.5 nM
CC(C)(C)NC(=O)C(c1ccncc1)N(Cc1cccs1)C(=O)Cn1nnc(-c2cccs2)n1 CHEMBL1524508 Potency 199.5 nM
CN(Cc1ccccc1)c1nc2c(c(=O)[nH]c(=O)n2C)n1CCCSc1ncccn1 CHEMBL579362 Potency 199.5 nM
Cc1ccc(C(c2nnnn2Cc2ccccc2)N2CCN(Cc3ccccc3)CC2)cc1 CHEMBL1573478 Potency 199.5 nM
O=C(/C=C/c1cccc(Cl)c1)NCc1ccncc1 CHEMBL1499184 Potency 199.5 nM
COc1ccccc1-c1nnc2sc(-c3ccc(N(C)C)cc3)nn12 CHEMBL1483593 Potency 199.5 nM
CC1CCN(c2nc3c(c(=O)[nH]c(=O)n3C)n2Cc2ccccc2)CC1 CHEMBL1549342 Potency 199.5 nM
CN(C)c1ccc(C(=O)c2ccc(N(C)C)c3ccccc23)cc1 CHEMBL460601 Potency 199.5 nM
COc1cccc(C2c3c(ncn(-c4cccc(F)c4)c3=N)Oc3ccc4ccccc4c32)c1 CHEMBL1354094 Potency 219.6 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C CHEMBL1593439 Potency 219.6 nM
CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 CHEMBL1801338 IC50 239.0 nM
O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 CHEMBL1289780 pIC50 251.19 nM
Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C CHEMBL1314147 Potency 251.2 nM
CCN(CC)S(=O)(=O)c1cccc(-c2nnc(SCC(=O)NC)n2CCc2ccccc2)c1 CHEMBL1538849 Potency 251.2 nM
CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21 CHEMBL1256778 Potency 251.2 nM
CCN1C(=O)/C(=C/c2nc3ccccc3c(=O)n2-c2ccc(C)cc2)c2ccccc21 CHEMBL1412792 Potency 251.2 nM
O=C(Nc1nc2c(s1)CCCC2)c1ccc2ncsc2c1 CHEMBL1401242 Potency 251.2 nM
COc1ccccc1-c1cc(C(=O)N2CCN(c3ccc(F)cc3)CC2)no1 CHEMBL1596789 Potency 251.2 nM
COc1ccc(NC(=O)c2cc(-c3ccc(C)o3)nc3ccccc23)cc1OC CHEMBL1539824 Potency 251.2 nM
COc1ccc(OC)c(NC(=O)c2nnn(CCc3ccccc3)c2N)c1 CHEMBL1324085 Potency 251.2 nM
c1ccc2c3c(cc(N4CCOCC4)c2c1)OC1(N2CCOCC2)CCCCC1O3 CHEMBL1606433 Potency 251.2 nM
Cc1ccc(Cl)cc1N1CCN(S(=O)(=O)c2ccc3c(c2)oc(=O)n3C)CC1 CHEMBL601176 Potency 251.2 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12 CHEMBL274826 Potency 251.2 nM
CC(C)(C)SCCNS(=O)(=O)c1ccccc1 CHEMBL1310431 Potency 251.2 nM
Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc21 CHEMBL33884 Potency 251.2 nM
Cc1ccc(NC2=NC(c3ccc(O)cc3)n3c(nc(C)cc3=O)N2)cc1 CHEMBL1579406 Potency 251.2 nM
Cc1c(OCc2nn[nH]n2)ccc2c(-c3ccccc3)cc(=O)oc12 CHEMBL1505052 Potency 251.2 nM
COc1ccc(Cn2nnnc2C(C(C)C)N(Cc2ccco2)Cc2cccs2)cc1 CHEMBL1423370 Potency 251.2 nM
CC1CC(C)CN(c2ncc3c(n2)CC(c2ccccc2)CC3=O)C1 CHEMBL1304045 Potency 251.2 nM
Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O CHEMBL62350 Potency 251.2 nM
C=C(C)COc1ccc(-c2ncncc2Oc2ccc(OC)cc2)c(O)c1 CHEMBL1597968 Potency 251.2 nM
O=C(NCCc1cccs1)C12CN(Cc3ccccc3)CC1C(c1cccc([N+](=O)[O-])c1)=NO2 CHEMBL1544862 Potency 251.2 nM
CC1(C)OC(C(=O)NC2CCCCC2)C(C(=O)NC2CCCCC2)O1 CHEMBL1392108 Potency 251.2 nM
Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801270 IC50 254.0 nM
C=CC1CN2CCC1CC2[C@@H](OC(=O)c1ccc(OC)cc1)c1ccnc2ccccc12 CHEMBL1198248 Potency 281.8 nM
CCOC(=O)c1cnc(Nc2nc3ccccc3o2)nc1CSC(=S)N(CC)CC CHEMBL1537810 Potency 316.2 nM
O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 CHEMBL1330510 Potency 316.2 nM
CCOc1cc(S(=O)(=O)NCCc2cccc(C)c2)c(OCC)cc1-n1cnnn1 CHEMBL1557435 Potency 316.2 nM
COCCn1nnnc1CN1CCN(c2cccc(C(F)(F)F)c2)CC1 CHEMBL1393035 Potency 316.2 nM
CCCc1nc2ccc(NC(=O)NCCC(=O)OCC)cc2c(=O)n1Cc1ccc(Cl)cc1 CHEMBL1610593 Potency 316.2 nM
CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2 CHEMBL540034 Potency 316.2 nM
CC(C)CCNC(=O)CN(CCN1CCOCC1)C(=O)Cn1nnc(-c2ccc(F)cc2)n1 CHEMBL1518863 Potency 316.2 nM
CCOc1ccc(NC2=NCC(=O)N2CCc2ccccc2)cc1 CHEMBL1339035 Potency 316.2 nM
Cc1csc(NC(=O)C2CCC(C)(C(=O)O)C2(C)C)n1 CHEMBL1536413 Potency 316.2 nM
CC(C)Oc1nnnn1-c1ccccc1 CHEMBL1343067 Potency 316.2 nM
COCCN1Cc2cccc(C(=O)Nc3c(C)cc(C)cc3C)c2C1=O CHEMBL1386408 Potency 316.2 nM
CCn1cc(C(=O)NCc2cccs2)c(=O)c2ccc(C)nc21 CHEMBL1306408 Potency 316.2 nM
Cc1cc(C)n(-c2nc(Nc3ccccc3C(F)(F)F)nc(-n3nc(C)cc3C)n2)n1 CHEMBL1448732 Potency 316.2 nM
COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O CHEMBL140 Potency 316.2 nM
Cc1ccc(Nc2nc(-c3c(C)nc4ccccn34)cs2)cc1 CHEMBL1536981 Potency 316.2 nM
Cc1csc(-c2coc3cc(O)cc(C)c3c2=O)n1 CHEMBL1330311 Potency 316.2 nM
COc1ccc(NC(C)=O)cc1NC(C)C(=O)Nc1cccc2ccccc12 CHEMBL1324389 Potency 316.2 nM
CCN(CC)C(=O)Cn1nc(C)c2ccccc2c1=O CHEMBL1529297 Potency 316.2 nM
O=C(CSc1nccn1-c1ccc(Cl)cc1)NCc1ccc2c(c1)OCO2 CHEMBL1322326 Potency 316.2 nM
CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 CHEMBL1201012 Potency 316.2 nM
CC(C)(C)NC(=O)NC(=O)COc1ccccc1C#N CHEMBL1311534 Potency 316.2 nM
CCOC(=O)c1snc(-c2ccc(F)cc2)c1N CHEMBL1367886 Potency 316.2 nM
CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O CHEMBL101 Potency 316.2 nM
CC(C)(C)c1nnc2sc(SCC(=O)N3CCCc4ccccc43)nn2c1=O CHEMBL1400110 Potency 316.2 nM
Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801271 IC50 321.0 nM
Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 CHEMBL1210241 IC50 326.0 nM
Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 CHEMBL1801318 IC50 336.0 nM
Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 CHEMBL1801269 IC50 351.0 nM
O=C(Nc1cc(O)nc2nc(-c3ccc(Cl)cc3)nn12)c1ccccc1 CHEMBL1371924 Potency 354.8 nM
CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C CHEMBL1323851 Potency 354.8 nM
Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 CHEMBL1801319 IC50 358.0 nM
N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 CHEMBL1801268 IC50 369.0 nM
N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 CHEMBL1801321 IC50 387.0 nM
Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 CHEMBL1210412 IC50 398.0 nM
CC(C)CCn1c(SCC#N)nc2c(sc3ccccc32)c1=O CHEMBL1564940 Potency 398.1 nM
Cc1ccc(S(=O)(=O)N2CCCC(C(=O)NCc3cccnc3)C2)cc1Cl CHEMBL1412160 Potency 398.1 nM
N[C@H](C(=O)O)c1cc(O)cc(O)c1 CHEMBL39221 Potency 398.1 nM
CN(C)c1nc(N2CCN(c3ccc(F)cc3)CC2)c(C#N)c(=O)o1 CHEMBL1464198 Potency 398.1 nM
Cn1c2c(c(=O)n(C)c1=O)C(CC(=O)Nc1ccccc1)C(=O)N2 CHEMBL1433125 Potency 398.1 nM
COC1CCCCC1NS(=O)(=O)c1ccccc1 CHEMBL1372720 Potency 398.1 nM
CCCC1=Nc2cc(C(=O)NCCCOCC)ccc2Sc2ccccc21 CHEMBL1584985 Potency 398.1 nM
O=C(N1CCCCC1)C1(c2ccccc2)CCOCC1 CHEMBL1379130 Potency 398.1 nM
CCOC(=O)c1sc(NC(=O)c2cccc(S(=O)(=O)N3CCN(C)CC3)c2)cc1C CHEMBL1594237 Potency 398.1 nM
CCc1ccc(CCC(=O)Nc2ccc(C)c(C)c2)o1 CHEMBL1373226 Potency 398.1 nM
Nc1ccc(CCNc2ncnc3c2ncn3C2OC(CO)C(O)C2O)cc1 CHEMBL326958 Potency 398.1 nM
Cc1ccccc1-n1c(S)nnc1-c1ccc2ccccc2n1 CHEMBL1324104 Potency 398.1 nM
COC(=O)c1cc2oc(C)cc2n1CC(=O)N(C)c1ccccc1 CHEMBL1491738 Potency 398.1 nM
Cc1nc2ccccc2nc1CSc1nnc(N)s1 CHEMBL1401603 Potency 398.1 nM
N=C(N)SCCc1ccc(CCSC(=N)N)cc1 CHEMBL1451880 Potency 398.1 nM
CN(C(=O)COC(=O)c1ccc(Cl)cc1N)C1CCS(=O)(=O)C1 CHEMBL1362038 Potency 398.1 nM
NCCNS(=O)(=O)c1cccc2c(Cl)cccc12 CHEMBL1255867 Potency 398.1 nM
O=C(c1[nH]nc2ccccc12)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 CHEMBL1561030 Potency 398.1 nM
COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc4c(c3)OCO4)on2)CC1 CHEMBL1419950 Potency 398.1 nM
COc1ccc(OC)c(NC(=O)c2ccccc2NS(=O)(=O)c2cccc3cccnc23)c1 CHEMBL1563699 Potency 398.1 nM
Cc1cc(O)c(C(C)C)cc1NC(=O)Nc1cccc2ccccc12 CHEMBL1330763 Potency 398.1 nM
O=C(CSc1nccc(O)n1)c1ccccc1Br CHEMBL1420316 Potency 398.1 nM
CCn1cnc2sc(C(=O)N(Cc3ccc(N(C)C)cc3)Cc3ccco3)c(C)c2c1=O CHEMBL1304158 Potency 398.1 nM
CC(NC=C1C(=O)NC(=O)NC1=O)c1ccccc1 CHEMBL1548330 Potency 398.1 nM
CCc1ccc(NC(=O)N(CCCN2CCOCC2)C(C)c2cc3cccc(OC)c3o2)cc1 CHEMBL1609802 Potency 398.1 nM
Cc1ccc(/C=C/C(=O)O)cc1S(=O)(=O)NCCCO CHEMBL1567615 Potency 398.1 nM
COc1ccccc1-c1nc(C#N)c(N2CCc3ccccc3C2)o1 CHEMBL1538120 Potency 398.1 nM
CC(=O)Nc1nnc(SCC(=O)NCC2CCCO2)s1 CHEMBL1580093 Potency 398.1 nM
Cc1ccnc(NS(=O)(=O)c2ccccc2)n1 CHEMBL1502614 Potency 398.1 nM
O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)Nc1ccccc1F CHEMBL1522857 Potency 398.1 nM
Cc1cc(/C=N/NC(=O)C(O)(c2ccccc2)c2ccccc2)c(C)n1-c1ccccc1 CHEMBL3194476 Potency 398.1 nM
CNCCc1c[nH]c2ccc(O)cc12 CHEMBL1256286 Potency 398.1 nM
CC1CCN(CCCNC(=O)c2cn(C)c3ccc(S(=O)(=O)N4CCCC4)cc3c2=O)CC1 CHEMBL1518078 Potency 398.1 nM
O=C(CN(C(=O)CSc1nnc(COc2ccccc2)o1)c1ccc(F)cc1)NC1CCCC1 CHEMBL1580672 Potency 398.1 nM
CCc1ccc(NC(=O)c2cnn3ccccc23)cc1 CHEMBL1571647 Potency 398.1 nM
CCC(C)(C)NC(=O)C(c1ccc(F)cc1)N(Cc1ccco1)C(=O)c1cnccn1 CHEMBL1308429 Potency 398.1 nM
Cc1[nH]c2ccccc2c1C1=CN2CCS(=O)(=O)N=C2S1 CHEMBL1584040 Potency 398.1 nM
COc1cccc(C2c3c(ncn(-c4ccccc4SC)c3=N)Oc3ccc4ccccc4c32)c1 CHEMBL1314118 Potency 438.2 nM
C=C(C=O)C[C@@H]1C[C@H](O)C2OC3C[C@]4(C)OC5/C=C\CC6OC7C(CC=CCC6OC5CCCC4OC3CC2O1)OC1CC2OC3CC(=O)OC3C[C@@H](C)C[C@@]2(C)OC1C[C@@H]7C CHEMBL1448627 Potency 501.2 nM
COc1ccc(/C=N/n2cncn2)cc1Cn1cc([N+](=O)[O-])cn1 CHEMBL3210867 Potency 501.2 nM
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)CC4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1587386 Potency 501.2 nM
CCN(CC)S(=O)(=O)c1ccc2oc(C(=O)O)c(C)c2c1 CHEMBL1607020 Potency 501.2 nM
COc1ccc2nc(O)c(CN(CC3CCCO3)C(S)=Nc3cccc(C)c3)cc2c1 CHEMBL1584383 Potency 501.2 nM
CC1CC(C)CN(C(=O)c2ccc3c(c2)N(Cc2ccccc2)CCS3)C1 CHEMBL1510765 Potency 501.2 nM
Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL267777 Potency 501.2 nM
Cc1cccc(C)c1OCC(=O)OCC(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL1403073 Potency 501.2 nM
COc1ccc(CCNC(=O)CCSc2nc(-c3ccco3)cc(C(F)(F)F)n2)cc1 CHEMBL1531513 Potency 501.2 nM
CC(=O)Nc1ccc(S(=O)(=O)NCCc2ccccc2)cc1 CHEMBL1323548 Potency 501.2 nM
Cc1cccc(OCC(O)Cn2c(NCc3cccnc3)nc3c2c(=O)[nH]c(=O)n3C)c1 CHEMBL1530456 Potency 501.2 nM
CCOC(=O)c1ccc(Oc2nc(SC)nc(N(C)C)n2)cc1 CHEMBL1539570 Potency 501.2 nM
COc1ccc(CNC(=O)C(c2ccc(C)o2)N(Cc2cccs2)C(=O)Cc2cccs2)cc1 CHEMBL1542792 Potency 501.2 nM
CCOC(=O)c1cccc(NC(=O)CCn2cccc2)c1 CHEMBL1457117 Potency 501.2 nM
CCC1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)C3[C@]45CCN4CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]3(O)C(=O)OC)[C@H]45)C2)C1 CHEMBL1437846 Potency 501.2 nM
COc1ccccc1N1CCN(C(=O)c2cc3c(s2)CCC3)CC1 CHEMBL1442697 Potency 501.2 nM
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccccc1 CHEMBL1256943 Potency 501.2 nM
COC(=O)c1ccc(C2c3c(C)n[nH]c3C(=O)N2c2ccc(C)cc2)cc1 CHEMBL1546483 Potency 501.2 nM
S=C(Nc1ccccc1)Nc1nccs1 CHEMBL1256364 Potency 501.2 nM
CCC(C)(C)n1nnnc1C(c1ccc(O)c(OC)c1)N1CCN(c2nc3ccccc3s2)CC1 CHEMBL1479729 Potency 501.2 nM
CCOC(=O)c1ccc(NC(=O)CSc2n[nH]c(-c3ccncc3)n2)cc1 CHEMBL1465414 Potency 501.2 nM
COc1ccc(NC(=O)/C=C/c2ccc(Cl)cc2)cc1 CHEMBL1367076 Potency 501.2 nM
Cc1cc2cc(CN(CCCN3CCOCC3)C(=O)NC3CCCCC3)c(O)nc2cc1C CHEMBL1451970 Potency 501.2 nM
O=C(Nc1ccc(Br)cc1F)c1sccc1-n1cccc1 CHEMBL1419718 Potency 501.2 nM
CCOc1ccc(NC(=O)Nc2nnc(CC)s2)cc1 CHEMBL1300260 Potency 501.2 nM
O=C(CNS(=O)(=O)c1ccc2ccccc2c1)OCC(=O)c1ccc(Br)s1 CHEMBL1556190 Potency 501.2 nM
O=C1NC(=O)N(CCc2ccccc2)C(=O)/C1=C(O)/C=C/c1c[nH]c2ccccc12 CHEMBL1531654 Potency 501.2 nM
COC(=O)c1c(NC(=O)C2(C)Cc3ccccc3C(=O)O2)sc2c1CCCC2 CHEMBL1350641 Potency 501.2 nM
COc1cc(NC(=O)C2CCN(S(=O)(=O)c3ccc(Cl)cc3)CC2)ccc1-n1cnnn1 CHEMBL1446015 Potency 501.2 nM
CCOC(=O)/C(C#N)=C1\C(=O)N(Cc2ccccc2)c2ccccc21 CHEMBL1351514 Potency 501.2 nM
COc1ccc(Nc2ncccc2C(=O)O)cc1 CHEMBL1559022 Potency 501.2 nM
CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1 CHEMBL1987060 Potency 501.2 nM
CC1=Nc2ncnn2C(c2cccnc2)/C1=C(\O)OCc1ccccc1 CHEMBL1987511 Potency 501.2 nM
Cn1c(SCC(=O)N2CCN(c3ccccc3)CC2)nnc1-c1ccccc1 CHEMBL1337831 Potency 501.2 nM
O=C(C(Sc1ccccc1)c1ccccc1)N1CCN(c2ccccc2F)CC1 CHEMBL1367897 Potency 501.2 nM
C=C[C@@H]1C[N@@]2CC[C@@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12 CHEMBL1567959 Potency 501.2 nM
COc1cccc(NC(=O)C2C3C=CC(O3)C2C(=O)NCc2cccnc2)c1 CHEMBL1463284 Potency 501.2 nM
CCn1cc(C(=O)OCC(=O)c2cc(C)n(-c3cccc(C(F)(F)F)c3)c2C)c(=O)c2ccc(C)nc21 CHEMBL1392351 Potency 501.2 nM
O=C(Nc1ccc(Cl)cc1)N(C1=NCCC1)c1ccc(OC(F)F)cc1 CHEMBL1431850 Potency 501.2 nM
CC(C)C(=O)c1cc2c(cc1NC(=O)Nc1cccc3ccccc13)OCCO2 CHEMBL1459978 Potency 501.2 nM
O=C(O)CCN1C(=O)c2ccncc2C1=O CHEMBL1580599 Potency 501.2 nM
COc1ccc(OC)c(C2C3=C(O)OCC3=Nc3cc4c(cc32)OCO4)c1 CHEMBL1338060 Potency 501.2 nM
C=CCc1cccc(CNc2c(C)n(C)n(-c3ccccc3)c2=O)c1O CHEMBL1490389 Potency 501.2 nM
CC1CCN(S(=O)(=O)c2ccc3c(c2)C(=NO)c2cc(S(=O)(=O)N4CCC(C)CC4)ccc2-3)CC1 CHEMBL1588525 Potency 501.2 nM
COc1cccc(C2c3c(ncn(-c4ccc5c(c4)OCO5)c3=N)Oc3ccc4ccccc4c32)c1 CHEMBL1314086 Potency 551.7 nM
COc1cccc(N2CCN(c3[nH]cnc4c5cc(F)ccc5nc3-4)CC2C)c1 CHEMBL1575588 Potency 631.0 nM
O=C1CSC(c2ccccc2)N1c1nc(-c2ccc(Cl)cc2Cl)cs1 CHEMBL1305203 Potency 631.0 nM
CCc1noc(C)c1C(=O)N1CC(C)OC(C)C1 CHEMBL1313142 Potency 631.0 nM
O=Cc1cc2ccccc2nc1SCc1ccc(Cl)c(Cl)c1 CHEMBL1342029 Potency 631.0 nM
COc1cccc(C(=O)N/N=c2\oc3c(OC)cccc3cc2C(=O)NCc2ccccc2)c1 CHEMBL3213758 Potency 631.0 nM
c1ccc(-n2ncc3c(NCc4ccco4)ncnc32)cc1 CHEMBL1371386 Potency 631.0 nM
CCCn1nc(C(=O)Nc2cccc(C(=O)OC)c2)c2ccccc2c1=O CHEMBL1539540 Potency 631.0 nM
CCc1ccc(C(=O)/C=C/c2ccc([N+](=O)[O-])o2)cc1 CHEMBL1363614 Potency 631.0 nM
CN1C(=O)SC(Nc2ccccc2)C1=O CHEMBL1333012 Potency 631.0 nM
CC(NC(=O)CCC(=O)NC(C)C1COc2ccccc2O1)C1COc2ccccc2O1 CHEMBL1369892 Potency 631.0 nM
Cc1nc2nc(C)c(CCC(=O)N3CCC4(CC3)OCCO4)c(C)n2n1 CHEMBL1454885 Potency 631.0 nM
Cc1cccc2cc(CN(CC3CCCO3)C(c3nnnn3Cc3ccco3)C(C)C)c(O)nc12 CHEMBL1599037 Potency 631.0 nM
COc1ccccc1C1C2=C(O)OCC2=Nc2cc3c(cc21)OCO3 CHEMBL1378769 Potency 631.0 nM
Cc1ccc(-c2csc(NC(=O)CSc3ncn(-c4ccccc4)n3)n2)cc1 CHEMBL1321699 Potency 631.0 nM
Cc1ccccc1NC(=O)N1C2CCCC1CC(NC(=O)C(C)(C)C)C2 CHEMBL1336534 Potency 631.0 nM
O=C(COc1ccccc1Cl)NCc1ccncc1 CHEMBL1562981 Potency 631.0 nM
COc1ccc(N2CCN(C(CNC(=O)C3CCCCC3)c3cccnc3)CC2)cc1 CHEMBL1575007 Potency 631.0 nM
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 CHEMBL359744 Potency 631.0 nM
CCCCCCn1c(SCC(=O)c2ccccc2)nc2c1c(=O)[nH]c(=O)n2C CHEMBL1489666 Potency 631.0 nM
COc1ccc(CNc2nc(-c3cccnc3)nn2C(=O)c2ccco2)cc1 CHEMBL1572848 Potency 631.0 nM
Cc1ccc(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2ccccn2)cc1 CHEMBL1546902 Potency 631.0 nM
CCCn1nnc(NC(=O)c2ccc(Br)cc2)n1 CHEMBL1303345 Potency 631.0 nM
O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F CHEMBL1200822 Potency 631.0 nM
CC(=O)c1ccc(N2CCN(C(=O)C3(S(=O)(=O)c4ccc(Cl)cc4)CC3)CC2)cc1 CHEMBL1328983 Potency 631.0 nM
COCc1nc2ccccc2n1Cc1ccc(Br)cc1 CHEMBL1595277 Potency 631.0 nM
O=C(O)Cn1nc(C(F)(F)F)c2c1CCCCC2 CHEMBL1413287 Potency 631.0 nM
O=C(c1cc(-c2cccnc2)nc2ccc(Br)cc12)N1CCN(c2ncccn2)CC1 CHEMBL1351484 Potency 631.0 nM
CC(=O)c1cc2c(cc1NC(=O)CN1CCC(Cc3ccccc3)CC1)OCO2 CHEMBL1608351 Potency 631.0 nM
Cc1cc(C)cc(-n2c(C)cc(/C=N/NC(=O)CSc3ncccn3)c2C)c1 CHEMBL1986187 Potency 631.0 nM
CC(Oc1ccc(Cl)cc1Cl)C(=O)Nc1ccc(S(=O)(=O)Nc2cnc3ccccc3n2)cc1 CHEMBL1559100 Potency 631.0 nM
Cc1csc(Sc2ccc([N+](=O)[O-])cc2C(=O)OCC(=O)NC2CCCC(C)C2C)n1 CHEMBL1335099 Potency 631.0 nM
CC(N)Cc1c[nH]c2ccc(O)cc12 CHEMBL1256710 Potency 631.0 nM
CCN(C1CCCCC1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL1459493 Potency 631.0 nM
CC(C)(C)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCOCC2)o1 CHEMBL1414617 Potency 631.0 nM
CCC1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)C3[C@]45CCN4CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]3(O)C(=O)OC)[C@H]45)C2)C1 CHEMBL1554098 Potency 631.0 nM
Cc1cc(-n2c(C)cc(C(=O)CSc3nnc4sc5ccccc5n34)c2C)no1 CHEMBL1583586 Potency 631.0 nM
CC(C)C(=O)Nc1c2c(nc3c1CCC3)CCCC2 CHEMBL1444244 Potency 631.0 nM
C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3 CHEMBL542493 Potency 631.0 nM
CC(C)(C)c1csc(NC(=O)c2ccc(Cl)s2)n1 CHEMBL1528822 Potency 631.0 nM
COC(=O)C1=C(C)NC(C)=C([N+](=O)[O-])C1c1ccccc1C(F)(F)F CHEMBL1082832 Potency 631.0 nM
N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1801326 IC50 635.0 nM
Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 CHEMBL1800088 IC50 660.0 nM
COc1ccc(C2c3ccccc3Oc3ncn(CCN4CCOCC4)c(=N)c32)cc1OC CHEMBL1511885 Potency 694.5 nM
CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 CHEMBL1210179 IC50 725.0 nM
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O CHEMBL1544 Potency 794.3 nM
CCOC(=O)CC(=O)Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 CHEMBL1408160 Potency 794.3 nM
Cc1ccc(Cl)cc1N1CCN(C(=O)CSc2nnc3n2C(C)(C)Cc2ccccc2-3)CC1 CHEMBL1305122 Potency 794.3 nM
CCOC(=O)c1[nH]c2c(c1C)C(=O)CC(c1ccco1)C2 CHEMBL1424468 Potency 794.3 nM
Cc1ccc(C)c(C(NC(=O)COc2ccc(Cl)cc2[N+](=O)[O-])c2ccccc2)c1 CHEMBL1610389 Potency 794.3 nM
CC(/C=N/O)Cc1ccc2c(c1)OCO2 CHEMBL3212727 Potency 794.3 nM
NC(=O)OCC(COC(N)=O)c1ccccc1 CHEMBL1094 Potency 794.3 nM
Cn1c(=O)cc(OCCCC(=O)N2CCC3(CC2)OCCO3)c2ccccc21 CHEMBL1421602 Potency 794.3 nM
O=C(O)CSc1nnc(-c2cccs2)n1-c1ccc(Cl)cc1 CHEMBL1523341 Potency 794.3 nM
CCCOc1cc(CC(=O)NCc2ccco2)ccc1OC CHEMBL1374410 Potency 794.3 nM
COc1ccc(OC)c(NC(=O)CSc2nnc(CNc3ccc(C)cc3C)o2)c1 CHEMBL1376052 Potency 794.3 nM
CCc1c(C#N)c(SCCC(=O)Nc2ccc(C)cc2)nc2c1C(=O)CC(C)(C)C2 CHEMBL1363987 Potency 794.3 nM
COC(=O)C(CC(C)C)Oc1ccc2c(C)cc(=O)oc2c1 CHEMBL1488203 Potency 794.3 nM
Oc1ccc(-c2nc3ccccn3c2NCc2ccc3c(c2)OCO3)cc1 CHEMBL1494350 Potency 794.3 nM
CCn1c(COc2ccc3c(c2)OCO3)nnc1SCC(=O)c1ccccc1 CHEMBL1425765 Potency 794.3 nM
Cc1ccc(/C=C2\SC(=S)N(CC(=O)Nc3ncc(Cc4ccccc4Cl)s3)C2=O)cc1 CHEMBL1379758 Potency 794.3 nM
c1ccc(-n2ncc3c(N4CCCC4)ncnc32)cc1 CHEMBL1555979 Potency 794.3 nM
COc1ccc(N(CC(=O)Nc2cc(Cl)ccc2OC)S(=O)(=O)c2c(C)noc2C)cc1 CHEMBL1440659 Potency 794.3 nM
COc1ccccc1NC(=O)CSc1nnc(Cc2cccn2C)n1CCc1ccccc1 CHEMBL1419549 Potency 794.3 nM
CCC1(CC)C(=O)N=C(NCCc2c[nH]c3ccccc23)NC1=O CHEMBL1333221 Potency 794.3 nM
O=C(C(Cc1ccccc1)N1C(=O)c2ccccc2C1=O)N1CCc2ccccc21 CHEMBL1322015 Potency 794.3 nM
CCOC(=O)c1cc(-c2nnc(SCC(=O)Nc3ccc(F)cc3)o2)c(C)nc1C CHEMBL1521986 Potency 794.3 nM
CCOC(=O)Cc1c(C)nc2c(-c3ccccc3)c(C)nn2c1C CHEMBL1310604 Potency 794.3 nM
CCO[C@@H]1OC(C(=O)NCc2nc3ccccc3[nH]2)=C[C@H](c2ccc(C(F)(F)F)cc2)[C@H]1CCCO CHEMBL1340359 Potency 794.3 nM
COC(=O)c1ccc(COc2cc(O)c3c(c2)OC(C)(C)CC3=O)cc1 CHEMBL1570469 Potency 794.3 nM
COc1ccccc1N1CCN(C(c2cc3ccc(C)cc3nc2O)c2nnnn2C2CCCC2)CC1 CHEMBL1522249 Potency 794.3 nM
Cc1cc(C(C)(C)C)oc1C(=O)N(CC(=O)NC1CCCC1)Cc1ccccc1 CHEMBL1524765 Potency 794.3 nM
CC1Cc2cc(-c3csc(NC(=O)Cc4ccccc4)n3)ccc2N1S(C)(=O)=O CHEMBL1609476 Potency 794.3 nM
O=C(CCCOc1ccc(Cl)cc1)N1CCCCCC1 CHEMBL1340976 Potency 794.3 nM
CCN(CC)c1ccc(-c2nn3c(-c4ccccc4OC)nnc3s2)cc1 CHEMBL1307769 Potency 794.3 nM
[O-][n+]1onc2c1CCc1c-2nn(-c2ccccc2Cl)[n+]1[O-] CHEMBL1602693 Potency 794.3 nM
Cc1nn(-c2ccccc2)c2sc(C(=O)NNC(=O)COc3ccccc3)cc12 CHEMBL1341103 Potency 794.3 nM
CCOc1ccccc1C(=O)N1CCN(c2cccc(Cl)c2)CC1 CHEMBL1360484 Potency 794.3 nM
O=C(COc1cccc(NC(=O)c2ccco2)c1)c1ccccc1 CHEMBL1463084 Potency 794.3 nM
C=CC1(C)CC(=O)C2(O)C(C)(O1)C(OC(C)=O)C(O)C1C(C)(C)CCC(O)C12C CHEMBL1358402 Potency 794.3 nM
Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(C)n2)cc1 CHEMBL1483676 Potency 794.3 nM
C=CCNS(=O)(=O)c1sccc1/C=N/O CHEMBL3207416 Potency 794.3 nM
COc1ccc(N2CCN(c3oc(COc4ccccc4)nc3C#N)CC2)cc1 CHEMBL1312641 Potency 794.3 nM
N#C/C(=C\c1ccc(O)c(O)c1)C(=O)NCCCc1ccccc1 CHEMBL53898 Potency 794.3 nM
CCOC(=O)C1CCCN(C(=O)c2ccccc2SCCOC)C1 CHEMBL1454092 Potency 794.3 nM
O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 CHEMBL1289678 pIC50 794.33 nM
Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 CHEMBL1801328 IC50 851.0 nM
O=[N+]([O-])c1ccc(N=Nc2ccc(O)cc2O)cc1 CHEMBL1604790 Potency 891.3 nM
Cc1cc(Br)c2nc3c(c(C(=O)O)c2c1)CCCCC3 CHEMBL1499411 Potency 891.3 nM