C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO CHEMBL131 EC50 0.002 nM
NS(=O)(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4532472 pEC50 0.05012 nM
CN1CCN(n2/c(=N\C#N)[nH]c3cc(/C=C4\c5ccccc5COc5cc(F)ccc54)ccc32)CC1 CHEMBL4095917 Ki 0.08 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C=O)[C@@H](C(=O)CO)CC[C@@H]12 CHEMBL273453 EC50 0.18 nM
N#C/N=c1/[nH]c2cc(/C=C3/c4ccc(F)cc4OCc4c(F)cccc43)ccc2n1[C@H]1C[C@@H]2COCCN2C1 CHEMBL4086416 Ki 0.23 nM
CS(=O)(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4572476 pKi 0.3162 nM
C[C@@](c1ccc(F)cc1F)(c1c[nH]c2c(NS(C)(=O)=O)cccc12)C1CC1 CHEMBL235206 Ki 0.319 nM
C[C@H](CN1CCOCC1)n1/c(=N\C(N)=O)[nH]c2cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc21 CHEMBL4088896 Ki 0.33 nM
C/C(=C1/c2ccccc2COc2ccccc21)c1cccc(NS(C)(=O)=O)c1 CHEMBL3120319 Ki 0.342 nM
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO CHEMBL384467 Ki 0.36 nM
CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL103 Kd app 0.39 nM
O=c1[nH]c2cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc2n1[C@H]1C[C@H]2COCCN2C1 CHEMBL2181925 Ki 0.4 nM
C[C@H](CN1CCOCC1)n1/c(=N\C#N)[nH]c2cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc21 CHEMBL4099276 Ki 0.4 nM
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO CHEMBL110739 Kd 0.5 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO CHEMBL389621 Kd 0.5 nM
CC(C)Cc1cc2c(cc1Cl)OC[C@H](CC(N)=O)N2C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4471322 pKi 0.5012 nM
C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21C CHEMBL166444 Ki 0.54 nM
CNC(=O)C[C@H]1COc2cc(F)c(CC(C)C)cc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4555842 pKi 0.631 nM
CC(c1ccc(F)cc1)(c1c[nH]c2c(NS(C)(=O)=O)cccc12)C1CC1 CHEMBL1672542 Ki 0.64 nM
CC12CCC(=O)C=C1CCC1C2CCC2(C)C(C(=O)C=[N+]=[N-])CCC12 CHEMBL97531 Kd app 0.74 nM
C[C@H](CN1CCOCC1)n1/c(=N\C#N)[nH]c2cc(/C=C3\c4ccc(F)cc4COc4cc(F)ccc43)ccc21 CHEMBL4063735 Ki 0.79 nM
CC(C)Cc1cc2c(cc1F)OC[C@H](CS(N)(=O)=O)N2C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4463240 pIC50 0.7943 nM
CC/C(=C1/c2ccccc2COc2ccccc21)c1cccc(NS(C)(=O)=O)c1 CHEMBL3120318 Ki 0.967 nM
CNC(=O)C[C@H]1COc2cc(Cl)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4540313 pEC50 1.0 nM
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cc(C[C@H](C)O)n1-c1ccc(Cl)cc1-c1ccc(F)cc1 CHEMBL4087205 IC50 1.2 nM
Cc1noc(=O)c2ccc(NC(=O)C(O)(CC(C)(C)c3cc(F)ccc3O)C(F)(F)F)cc12 CHEMBL196374 pIC50 1.259 nM
CC(=O)Oc1ccc(CCc2cc(C)c3c(c2)NC(=O)CO3)c(C)c1 CHEMBL4102708 IC50 1.3 nM
C[C@](c1ccc(F)cc1F)(c1c[nH]c2c(NS(C)(=O)=O)cccc12)C1CC1 CHEMBL391231 Ki 1.51 nM
C[C@@](c1ccc(F)cc1)(c1c[nH]c2c(NS(C)(=O)=O)cccc12)C1CC1 CHEMBL235209 Ki 1.56 nM
CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12 CHEMBL1393 IC50 1.6 nM
C[C@]12C=CC(=O)C=C1[C@@H](F)C[C@H]1[C@@H]3C[C@H]4CN(Cc5ccc(CSc6ccc(O)cc6)cc5)C[C@@]4(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F CHEMBL4217175 EC50 1.6 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL3263752 IC50 1.8 nM
CC(C)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4468672 pKi 1.995 nM
COc1cc(C(=O)O)ccc1C1=NN(c2ccc(C#N)c(Cl)c2)[C@@H](C2CCCC2)C1 CHEMBL1215196 IC50 2.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(Cl)ccc3[nH]2)C1=O CHEMBL3578271 Ki 2.0 nM
O=C1COc2ccc(/C=C3\c4ccccc4COc4cc(F)ccc43)cc2N1 CHEMBL3775752 Ki 2.0 nM
CS(=O)(=O)Nc1cccc2c(-c3cccc(Cl)c3)c[nH]c12 CHEMBL3605932 Ki 2.1 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)Nc1nnn[nH]1 CHEMBL3263768 IC50 2.2 nM
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cn(CCO)c1-c1ccccc1C(F)(F)F CHEMBL2181932 IC50 2.4 nM
CS(=O)(=O)Nc1cccc(C=C2c3ccccc3CCc3ccccc32)c1 CHEMBL3120320 Ki 2.48 nM
C[C@]12C=CC(=O)C=C1[C@@H](F)C[C@H]1[C@@H]3C[C@H]4CN(Cc5cccc(Cl)c5)C[C@@]4(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F CHEMBL4204230 EC50 2.5 nM
CNC(=O)C[C@H]1COc2cc(Br)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4573596 pKi 2.512 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(N)=O CHEMBL3263760 IC50 2.7 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)NS(C)(=O)=O CHEMBL3263766 IC50 2.8 nM
CCC(O)C(CC)(c1ccc(Br)cc1)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4091159 IP 3.0 nM
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cc(C[C@H](C)O)n1-c1ccc(Cl)cc1C(F)(F)F CHEMBL4065788 IC50 3.1 nM
NC(=O)C[C@H]1COc2cc(F)c(C3CC3)cc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4581588 pKi 3.162 nM
C[C@]12C=CC(=O)C=C1[C@@H](F)C[C@H]1[C@@H]3C[C@H]4CN(Cc5ccc(C(F)(F)F)cc5)C[C@@]4(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F CHEMBL4211724 EC50 3.2 nM
CNC(=O)c1ccc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)nc1OC CHEMBL3263764 IC50 3.3 nM
C[C@@]12CCC(=O)C=C1[C@H]1C[C@H]1[C@@H]1[C@H]3[C@H]4C[C@H]4[C@]4(CCC(=O)O4)[C@]3(C)CC[C@H]12 CHEMBL3926496 IC50 3.3 nM
CC1=C(C#N)[C@@H](c2ccc(F)cc2Cl)C(C(=O)OC(C)(C)C)=C(C)N1 CHEMBL1097751 IC50 3.7 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)N(C)C CHEMBL3263762 IC50 3.7 nM
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cc(CCO)n1-c1ccc(Cl)cc1C(F)(F)F CHEMBL4064750 IC50 3.7 nM
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cn([C@H](C)[C@H](C)O)c1-c1ccc(F)cc1C(F)(F)F CHEMBL4078631 IC50 3.8 nM
CNC(=O)C[C@H]1COc2cc(C)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4483495 pKi 3.981 nM
NC(=O)C[C@H]1COc2cc(Cl)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3918276 pKi 3.981 nM
Cc1cc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCCC2)ccc1C#N CHEMBL1215486 IC50 4.0 nM
CCC(O)C(CC)(c1ccc(C(F)(F)F)cc1)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4085347 IP 4.0 nM
CCC(c1ccc(C(F)(F)F)cc1)(C(O)C(F)F)n1ncc2c(NS(=O)(=O)CC)cccc21 CHEMBL4097445 IP 4.0 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)ccc1C(=O)NS(C)(=O)=O CHEMBL3263767 IC50 4.1 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)ccc1C(N)=O CHEMBL3263763 IC50 4.3 nM
CCOc1nc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL3263757 IC50 4.4 nM
Cc1cc(F)ccc1CCc1ccnc(NC(N)=O)c1 CHEMBL3643690 IC50 4.7 nM
CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 CHEMBL1370 EC50 4.8 nM
CC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@]21C=CCO1 CHEMBL3692351 IC50 5.0 nM
CCOc1cc(C2=NN(c3ccc(C#N)c(Cl)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL1215197 IC50 6.0 nM
CN1CCC2(CC1)C(=O)Nc1cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc12 CHEMBL3774871 Ki 6.0 nM
CC1(C)OC(=S)Nc2ccc(S(=O)(=O)N3c4ccccc4COc4cc(F)ccc43)cc21 CHEMBL3775473 Ki 6.0 nM
CN(C)CC(=O)N1CCC2(CC1)C(=O)Nc1cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc12 CHEMBL3775389 Ki 6.0 nM
CC/C(=C1\c2ccccc2OCc2cccc(OC)c21)c1cccc(NS(C)(=O)=O)c1 CHEMBL3120317 Ki 6.1 nM
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cc([C@H](C)[C@H](C)O)n1-c1ccc(F)cc1C(F)(F)F CHEMBL4088459 IC50 6.2 nM
C[C@@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccccc2)CO1 CHEMBL2181928 Ki 6.3 nM
Cc1c(C(=O)Nc2ccc(S(C)(=O)=O)cc2)cc(CCF)n1-c1ccc(F)cc1OC(F)F CHEMBL4068898 IC50 6.5 nM
COc1cc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCCC2)ccc1C#N CHEMBL1215487 IC50 7.0 nM
O=C1Nc2cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc2C12CCNCC2 CHEMBL3775816 Ki 7.0 nM
CC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCC2)[C@@H]1c1cccc2c(=O)cc(C)oc12 CHEMBL4104632 IC50 7.0 nM
CCC(c1ccc(Br)cc1)(C(C)O)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4070216 IP 7.0 nM
Cc1ccccc1CCc1ccnc(NC(N)=O)c1 CHEMBL2181933 IC50 7.1 nM
C[C@](c1ccc(F)cc1)(c1c[nH]c2c(NS(C)(=O)=O)cccc12)C1CC1 CHEMBL391439 Ki 7.5 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL3263754 IC50 7.6 nM
COc1ccc(F)cc1C(C)(C)CC(O)(C(=O)Nc1ccc2c(=O)onc(C)c2c1)C(F)(F)F CHEMBL263091 pIC50 7.943 nM
NC(=O)C[C@H]1CNc2cc(Cl)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4544614 pKi 7.943 nM
CNC(=O)C[C@H]1COc2cc(F)c(CC(C)C)cc2N1C(=O)c1ccnc(NC(N)=O)c1 CHEMBL4463035 pKi 7.943 nM
Cc1nn(CCCC(F)(F)F)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337825 IC50 8.4 nM
COC(=O)C1=C(Cn2ccnc2)NC(C)=C(C#N)C1c1ccc(F)cc1Cl CHEMBL1215552 IC50 9.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCCC2)cc1Cl CHEMBL1215331 IC50 9.0 nM
COc1cc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL3263750 IC50 9.0 nM
O=c1[nH]c2cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc2n1[C@@H]1C[C@@H]2COCCN2C1 CHEMBL3775798 Ki 9.0 nM
CCC(O)C(CC)(c1ccc(C(F)(F)F)cc1)n1ncc2c(NS(C)(=O)=O)cc(F)cc21 CHEMBL4103277 IP 9.0 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)ccc1C(=O)N(C)C CHEMBL3263765 IC50 9.4 nM
NC(=O)Nc1cc(-c2ccnn2-c2ccc(Cl)cc2)ccn1 CHEMBL3643660 IC50 9.4 nM
NC(=O)C[C@H]1COc2cc(Br)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3940837 IC50 9.5 nM
COCc1ccsc1/C=C1\Oc2ccc(O)c(OC)c2-c2ccc3c(c21)C(C)=CC(C)(C)N3 CHEMBL395716 Ki 10.0 nM
CCCC1=C(C(=O)OCC)[C@H](c2ccnc3ccccc23)C(C#N)=C(C)N1 CHEMBL1094797 IC50 10.0 nM
Cc1nn(CCC(C)(F)F)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337831 IC50 10.0 nM
CNC(=O)CC1COc2cc(Br)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3910950 IC50 10.0 nM
O=C1COc2ccc(C(=O)N3c4cc(CC5CCCCC5)c(F)cc4OC[C@@H]3CCO)cc2N1 CHEMBL4448501 pKi 10.0 nM
CNC(=O)C[C@H]1COc2cc(F)c(OC(C)C)cc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4440231 pKi 10.0 nM
CCOc1cc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL3263751 IC50 10.7 nM
Cc1ccccc1C(C)Cc1ccnc(NC(N)=O)c1 CHEMBL3643674 IC50 11.0 nM
CCC(c1ccc(C(F)(F)F)cc1)(C(O)C(F)F)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4087287 IP 11.0 nM
CCC(c1ccc(C(F)(F)F)cc1)(C(O)C(F)F)n1ncc2c(NS(=O)(=O)CC)cc(F)cc21 CHEMBL4079411 IP 11.0 nM
Cc1cc(F)ccc1-n1nc(C(F)(F)F)cc1-c1cc(Cl)c2c(c1)NC(=O)CO2 CHEMBL1929041 IC50 12.0 nM
O=c1[nH]c2ccc(/C=C3\c4ccccc4COc4cc(F)ccc43)cc2[nH]1 CHEMBL3775714 Ki 12.0 nM
CNC(=O)C[C@H]1COc2cc(C(F)(F)F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4452144 pKi 12.59 nM
CNC(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3916929 pEC50 12.59 nM
NC(=O)C[C@H]1COc2cc(F)cc(F)c2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4455600 pEC50 12.59 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)c(OCCCO)c3)C[C@@H]2C2CCCC2)cc1Cl CHEMBL1215198 IC50 13.0 nM
O=C1CCc2c(/C=C3\c4ccccc4COc4cc(F)ccc43)cccc21 CHEMBL3775296 Ki 13.0 nM
NC(=O)Nc1cc(CC(c2ccccc2)c2ccccc2)ccn1 CHEMBL3643673 IC50 13.0 nM
NC(=O)Nc1cc(CCc2ccccc2C(F)(F)F)ccn1 CHEMBL3643686 IC50 13.0 nM
CNC(=O)CC1COc2cc(Cl)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3915760 IC50 13.0 nM
C[C@@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccccc2F)CO1 CHEMBL4086109 IC50 13.0 nM
C[C@@H]1CN(c2ccc3c(c2)NC(=O)CO3)[C@H](c2ccccc2)CO1 CHEMBL4097160 IC50 13.0 nM
COc1cc(C2=NN(c3ccc(C#N)c(Cl)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL1215130 IC50 14.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N([C@H](C)C3CCCCC3)C2=O)cc(OC)c1 CHEMBL2407646 IC50 14.0 nM
OC1CCc2c(/C=C3\c4ccccc4COc4cc(F)ccc43)cccc21 CHEMBL3775383 Ki 14.0 nM
Cc1ccc(-n2nccc2-c2ccnc(NC(N)=O)c2)cc1 CHEMBL3643658 IC50 14.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CC=CC2)cc1Cl CHEMBL1215409 IC50 15.0 nM
Cc1cc(F)ccc1-n1nc(C(F)(F)F)cc1-c1cc(C)c2c(c1)NC(=O)CO2 CHEMBL1929042 IC50 15.0 nM
CCC(O)C(CC(F)F)(c1ccc(C(F)(F)F)cc1)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4105147 IP 15.0 nM
CC[C@](C(=O)OC)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4792628 IC50 15.0 nM
Cc1ccc2c(c1)OC[C@](C)(CS(C)(=O)=O)N2C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4556735 pKi 15.85 nM
CCCC1=C(C(=O)OC)C(c2ccc(F)cc2Cl)C(C#N)=C(C)N1 CHEMBL1215549 IC50 16.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)C[C@@H]2C2CCCC2)cc1Cl CHEMBL1215127 IC50 16.0 nM
CCOc1ncc(C)c2c1[C@H](c1ccc(C#N)cc1OC)C(C(N)=O)=C(C)N2 CHEMBL2181927 IC50 16.0 nM
O=C(O)CCN1CCC2(CC1)C(=O)Nc1cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc12 CHEMBL3775464 Ki 16.0 nM
C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34C=CCO4)[C@@H]21 CHEMBL3692347 IC50 17.0 nM
CNC(=O)c1ccc(C2=NN(c3ccc(C#N)c(C)c3)[C@@H](C3CCCC3)C2)nc1OC CHEMBL3263761 IC50 17.8 nM
COc1cc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL3263755 IC50 18.0 nM
COC(=O)c1c(C)nc(C)c(C(=O)CC2CCC2)c1-c1cccc2c(=O)cc(C)oc12 CHEMBL4094464 IC50 18.0 nM
C[N+]1([O-])CCC2(CC1)C(=O)Nc1cc(/C=C3\c4ccccc4COc4cc(F)ccc43)ccc12 CHEMBL3774852 Ki 19.0 nM
CC1=C(C(=O)OC(C)C)C(c2cccc3c(=O)cc(C)oc23)C(C(=O)C(F)(F)F)=C(C)N1 CHEMBL4066981 IC50 19.0 nM
C[C@@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2cccc(F)c2)CO1 CHEMBL4064593 IC50 19.0 nM
C[C@@H](O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4(C)[C@H]3CCC12C(=O)C=[N+]=[N-] CHEMBL2112398 Kd app 20.0 nM
CC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4(C)[C@H]3CCC12C(=O)C=[N+]=[N-] CHEMBL2112397 Kd app 20.0 nM
O=C1COc2ccc(CCc3ccc(F)cc3F)cc2N1 CHEMBL3775710 Ki 20.0 nM
CC[C@@](c1ccc(C(F)(F)F)cc1)(C(C)O)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4528746 IC50 20.0 nM
COc1c(O)ccc2c1-c1ccc3c(c1/C(=C/c1sccc1/C(C)=N/O)O2)C(C)=CC(C)(C)N3 CHEMBL397919 Ki 21.0 nM
Cc1cc(-c2cccc3cc[nH]c23)c(Cl)c2c1NC(C)(C)CC2C CHEMBL258191 Ki 21.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCC2)cc1Cl CHEMBL1215408 IC50 21.0 nM
CC[C@](CO)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4439903 IC50 21.0 nM
Cc1nc(N2N=C(c3ccc(C(=O)O)cc3)C[C@@H]2C2CCCC2)ccc1C#N CHEMBL3263756 IC50 21.4 nM
CCCCn1nc(C)c(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1 CHEMBL3337823 IC50 22.0 nM
Cc1ccccc1C(Cc1ccnc(NC(N)=O)c1)C1CC1 CHEMBL3643675 IC50 22.0 nM
CC[C@@](c1ccc(C(F)(F)F)cc1)(C(C)O)n1ncc2c(NS(C)(=O)=O)cc(F)cc21 CHEMBL4473051 IC50 22.0 nM
CC1NC(=O)C(c2ccc(F)cc2)=C1c1cc(Cl)c2c(c1)NC(=O)CO2 CHEMBL2419300 IC50 23.0 nM
CC1=C(C#N)C(c2cccc3c2-c2ccccc2C3=O)C(C(=O)OC(C)C)=C(C)N1 CHEMBL4099077 IC50 23.0 nM
C[C@]12CCc3cc(C(=O)O)ccc3C1=NN(c1ccc(C#N)c(Cl)c1)[C@H]2C1CCCC1 CHEMBL1215626 IC50 25.0 nM
COc1ccc(-n2nccc2-c2ccnc(NC(N)=O)c2)cc1 CHEMBL3643662 IC50 25.0 nM
COc1ccccc1CCc1ccnc(NC(N)=O)c1 CHEMBL3643684 IC50 25.0 nM
COc1ccccc1CCc1cccc(NC(N)=O)n1 CHEMBL4075462 IC50 25.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)c(Cl)c3)C[C@@H]2C2CCCC2)cc1Cl CHEMBL1215129 IC50 26.0 nM
Cc1cc(N2N=C3c4ccc(C(=O)O)cc4CO[C@@H]3[C@@H]2C2CCCC2)ccc1C#N CHEMBL1215627 IC50 26.0 nM
CCOc1ncc(C)c2c1[C@H](c1ccc(C#N)cc1OC)C(C#N)=C(C)N2 CHEMBL4096901 IC50 26.0 nM
COc1ccccc1-c1c[nH]c2c(NS(C)(=O)=O)cccc12 CHEMBL3605933 Ki 27.4 nM
CCOC(=O)C1=C(C)NC(C)=C(C(C)=O)[C@H]1c1cccc2c(=O)cc(C)oc12 CHEMBL2181926 IC50 28.0 nM
CC(C)(CC(O)(C(=O)Nc1ccc2c(c1)COC2=O)C(F)(F)F)c1cc(F)ccc1O CHEMBL194745 IC50 30.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4cncnc4)ccc3[nH]2)C1=O CHEMBL3578290 IC50 30.0 nM
NC(=O)Nc1cc(CCc2ccc(F)cc2)ccn1 CHEMBL3643668 IC50 30.0 nM
COC(=O)C(CC1CC1)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4759836 IC50 30.0 nM
COc1nc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C(C)C)C2)ccc1C(=O)O CHEMBL3263759 IC50 30.7 nM
CCCC1=C(C(=O)OCC)C(c2ccnc3ccccc23)C(C#N)=C(C)N1 CHEMBL1098089 IC50 31.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)C[C@@H]2c2ccc(F)cc2)cc1Cl CHEMBL1214839 IC50 31.0 nM
O=C1COc2ccc(CN3c4ccccc4COc4cc(F)ccc43)cc2N1 CHEMBL3775476 Ki 31.0 nM
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@]21C=CCO1 CHEMBL3687970 IC50 31.0 nM
Cc1cc(-c2ccc(F)c3cc[nH]c23)c(Cl)c2c1NC(C)(C)CC2C CHEMBL257152 Ki 32.0 nM
Cc1nc(C)c(C2=NN(c3ccc(C#N)cc3)[C@@H](c3ccc(F)cc3)C2)s1 CHEMBL1215693 IC50 32.0 nM
CC[C@](CO)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cc(F)cc21 CHEMBL4578762 IC50 32.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N([C@@H]3CCc4ccccc43)C2=O)cc(OC)c1 CHEMBL2407647 IC50 33.0 nM
CCN1C(=O)C(c2ccc(F)cc2)=C(c2ccc3c(c2)NC(=O)CO3)C1C CHEMBL2419295 IC50 33.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4cnn(C)c4)ccc3[nH]2)C1=O CHEMBL3578282 IC50 33.0 nM
CC(Cc1ccnc(NC(N)=O)c1)c1ccccc1 CHEMBL3643677 IC50 33.0 nM
CC[C@@](c1ccc(Cl)cc1)(c1noc(C2CC2)n1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4764165 IC50 33.0 nM
COC(=O)C(c1ccc(Cl)cc1Cl)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4798697 IC50 33.0 nM
C[C@@H]1CN(c2ccc3c(c2)NC(=O)CO3)[C@H](c2ccccc2F)CO1 CHEMBL4091401 IC50 33.4 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4cccnc4)ccc3[nH]2)C1=O CHEMBL3578286 IC50 34.0 nM
O=C1COc2ccc(C3=Nn4ccnc4SC3c3ccccc3)cc2N1 CHEMBL1928877 IC50 36.0 nM
Cc1nn(Cc2cccnc2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337821 IC50 36.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4ccncc4)ccc3[nH]2)C1=O CHEMBL3578288 IC50 36.0 nM
C/C=C1\C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL410683 Ki 37.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N([C@H](C)c3ccc(F)cc3)C2=O)cc(OC)c1 CHEMBL2407644 IC50 37.0 nM
NC(=O)Nc1cc(CCc2ccccc2)ccn1 CHEMBL3643687 IC50 37.0 nM
Cc1noc(=O)c2ccc(NC(=O)C(O)(CC(C)(C)c3cccc4c3OCC4)C(F)(F)F)cc12 CHEMBL216272 IC50 38.0 nM
Cc1nn(CC(F)(F)CCO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337830 IC50 38.0 nM
Cc1cc(F)ccc1-n1nccc1-c1ccnc(NC(N)=O)c1 CHEMBL3643656 IC50 38.0 nM
CC[C@]12CC[C@H]3[C@@H]([C@H](C)CC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@]21C=CCO1 CHEMBL3692353 IC50 38.0 nM
COc1cc(NS(C)(=O)=O)c2[nH]c(C)c(-c3cc(F)ccc3OC)c2c1 CHEMBL3605924 Ki 38.4 nM
C/C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL402063 Ki 39.0 nM
Cc1cc(N2N=C3c4ccc(C(=O)O)cc4CO[C@H]3[C@H]2C2CCCC2)ccc1C#N CHEMBL1215625 IC50 39.0 nM
COc1cc(OC)cc(-c2nnc([C@@]3(Cc4ccccc4)OC(=O)N([C@H](C)c4ccccc4)C3=O)o2)c1 CHEMBL3234858 IC50 39.0 nM
Cc1nocc1-c1ccc2[nH]c([C@@]3(Cc4ccccc4)OC(=O)N([C@H](C)c4ccc(F)cc4)C3=O)nc2c1 CHEMBL3578284 IC50 39.0 nM
CC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2c(=O)cc(C)oc12 CHEMBL4102462 IC50 39.0 nM
C[C@@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccc(F)cc2)CO1 CHEMBL4078214 IC50 39.0 nM
CCC(CC)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4566136 IC50 39.0 nM
NS(=O)(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NCCO2 CHEMBL4557356 pKi 39.81 nM
Cc1noc(C)c1S(=O)(=O)NCc1ccc(-c2cccc(C#N)c2)cc1 CHEMBL3086013 IC50 40.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(N4CCOCC4)ccc3[nH]2)C1=O CHEMBL3578285 IC50 40.0 nM
COC(=O)C1=C(CCl)NC(C)=C(C#N)[C@H]1c1ccc(F)cc1Cl CHEMBL1094169 IC50 41.0 nM
N#Cc1ccc(N2N=C(c3ccc4[nH]c(=O)oc4c3)C[C@@H]2c2ccc(F)cc2)cc1 CHEMBL1215691 IC50 41.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2c2ccc(F)cc2)cc1Cl CHEMBL1215330 IC50 41.0 nM
Cc1cc(F)ccc1-n1nc(C(F)(F)F)cc1-c1ccc2c(c1)NC(=O)CO2 CHEMBL1929039 IC50 41.0 nM
CC/C=C(\C)c1ccsc1/C=C1\Oc2ccc(O)c(OC)c2-c2ccc3c(c21)C(C)=CC(C)(C)N3 CHEMBL428922 Ki 42.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4cn[nH]c4)ccc3[nH]2)C1=O CHEMBL3578281 IC50 42.0 nM
Cc1cc(C2=C(c3ccc(F)cc3)C(=O)NC2C)cc2c1OCC(=O)N2 CHEMBL2419301 IC50 43.0 nM
COc1cc(F)ccc1-c1c(C)[nH]c2c(NS(C)(=O)=O)cc(F)cc12 CHEMBL3605929 Ki 44.7 nM
COc1ccc(F)cc1C(C)(C)C[C@@](O)(Cc1cc2cc(C#N)ccc2[nH]1)C(F)(F)F CHEMBL1911650 IC50 45.0 nM
COc1ccc(C#N)cc1-c1ccc(CNS(=O)(=O)c2c(C)noc2C)cc1 CHEMBL3086014 IC50 45.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)[C@@H]1c1cccc([N+](=O)[O-])c1 CHEMBL1099083 IC50 46.0 nM
NC(=O)Nc1cc(-c2cc(C(F)(F)F)nn2-c2ccc(F)cc2)ccn1 CHEMBL3643645 IC50 47.0 nM
CCOc1nccc2c1[C@H](c1ccc(C#N)cc1OC)C(C#N)=C(C)N2 CHEMBL4068008 IC50 47.0 nM
Cc1cccc(-c2ccc3c(c2C)NC(=O)CO3)c1 CHEMBL4067551 IC50 47.0 nM
CO/N=C(\C)c1ccsc1/C=C1\Oc2ccc(O)c(OC)c2-c2ccc3c(c21)C(C)=CC(C)(C)N3 CHEMBL397920 Ki 48.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cn1ccc2ncccc21)C(F)(F)F CHEMBL1254994 IC50 48.0 nM
Cc1nn(CC(C)C)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337824 IC50 49.0 nM
CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C CHEMBL2440888 EC50 50.0 nM
CNC(=O)C[C@H]1COc2ccccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4453801 pKi 50.12 nM
NS(=O)(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2cc[nH]c2c1 CHEMBL4442787 pKi 50.12 nM
Cc1nn(CC(F)(F)CO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337829 IC50 51.0 nM
COC(=O)C1=C(C(F)(F)F)NC(C)=C(C#N)C1c1ccc(F)cc1Cl CHEMBL1215550 IC50 52.0 nM
COC(=O)C1=C(Cn2cnnn2)NC(C)=C(C#N)[C@H]1c1ccc(F)cc1Cl CHEMBL1215623 IC50 52.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)c(F)c3)C[C@@H]2C2CCCC2)cc1Cl CHEMBL1215128 IC50 52.0 nM
C[C@@H]1CN(c2cc3c(cn2)OCC(=O)N3)[C@H](c2ccccc2F)CO1 CHEMBL4069468 IC50 53.9 nM
COC(=O)C1=C(Cn2cccn2)NC(C)=C(C#N)C1c1ccc(F)cc1Cl CHEMBL1215620 IC50 54.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2C2CCCC2)cc1Cl CHEMBL1215126 IC50 54.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N([C@H](C)c3ccccc3)C2=O)cc(OC)c1 CHEMBL2407668 IC50 54.0 nM
Cc1ccccc1C(Cc1ccnc(NC(N)=O)c1)c1ccccc1 CHEMBL3643680 IC50 54.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N([C@H](C)c3ccc(Cl)cc3)C2=O)cc(OC)c1 CHEMBL2407645 IC50 55.0 nM
O=C1COc2ccc(/C=C(\c3ccccc3)c3ccc(F)cc3F)cc2N1 CHEMBL3774512 Ki 55.0 nM
C[C@@H]1CN(c2ccc3c(c2)NC(=O)CO3)[C@H](c2cccc(F)c2)CO1 CHEMBL4063566 IC50 55.0 nM
COc1nc(C2=NN(c3ccc(C#N)c(Cl)c3)[C@@H](C3CCCC3)C2)ccc1C(=O)O CHEMBL3263758 IC50 55.9 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccc(F)cc2)cc1Cl CHEMBL1214838 IC50 56.0 nM
Cc1cc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccc(F)cc2)ccc1C#N CHEMBL1214841 IC50 56.0 nM
O=C1COc2ccc(S(=O)(=O)N3c4ccccc4COc4cc(F)ccc43)cc2N1 CHEMBL3775370 IC50 56.0 nM
N#CC[C@@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccccc2)CO1 CHEMBL4100538 IC50 56.0 nM
C=C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34C=CCO4)[C@@H]21 CHEMBL3692349 IC50 57.0 nM
CCCCC1=C(C(=O)OC)C(c2ccccc2Cl)C(C#N)=C(C)N1 CHEMBL1215480 IC50 58.0 nM
N#Cc1ccc(N2N=C(c3ccc4[nH]c(=O)oc4c3)CC2c2ccc(F)cc2)cc1 CHEMBL1215690 IC50 58.0 nM
COc1ccc(F)cc1C(C)(C)C[C@@](O)(Cc1cc2cnccc2[nH]1)C(F)(F)F CHEMBL1253819 IC50 58.0 nM
CC1=C(C#N)C(c2ccc(F)cc2Cl)C(C(=O)OC(C)(C)C)=C(C)N1 CHEMBL1094114 IC50 59.0 nM
CC(O)(CC(C)(C)c1ccccc1)C(=O)Nc1ccc2c(c1)COC2=O CHEMBL195021 IC50 60.0 nM
CCC(C(=O)OC)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4794194 IC50 60.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4cnoc4)ccc3[nH]2)C1=O CHEMBL3578283 IC50 62.0 nM
NC(=O)Nc1cc(-c2ccnn2-c2ccc(F)cc2)ccn1 CHEMBL3643648 IC50 62.0 nM
NC(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4475012 pKi 63.1 nM
COC(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4566513 pKi 63.1 nM
COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]23O[C@@H]2C[C@@]2(C)[C@@H](CC[C@@]24CCC(=O)O4)[C@H]13 CHEMBL1095097 pIC50 63.1 nM
C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4557032 pIC50 63.1 nM
CCCC1=C(C(=O)OC)C(c2ccccc2Cl)C(C#N)=C(C)N1 CHEMBL1215406 IC50 64.0 nM
COC(=O)C1=C(Cn2cnnn2)NC(C)=C(C#N)C1c1ccc(F)cc1Cl CHEMBL1215622 IC50 64.0 nM
Cc1nn(Cc2ccccc2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337731 IC50 64.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4cccnc4Cl)ccc3[nH]2)C1=O CHEMBL3578289 IC50 64.0 nM
CC[C@](CO)(c1ccc(Cl)cc1)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4578220 IC50 64.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CO[C@@H]3[C@@H]2C2CCCC2)cc1Cl CHEMBL1215556 IC50 65.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cn2cc(C#N)c3ccccc32)C(F)(F)F)c(C)c1 CHEMBL3093456 IC50 65.0 nM
CC[C@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@]21C=CCO1 CHEMBL3692352 IC50 66.0 nM
CC1C(c2ccc3c(c2)NC(=O)CO3)=C(c2ccc(F)cc2)C(=O)N1C1CC1 CHEMBL2419296 IC50 68.0 nM
COc1cc(OC)cc(-c2cnc([C@@]3(Cc4ccccc4)OC(=O)N([C@H](C)c4ccccc4)C3=O)[nH]2)c1 CHEMBL3234850 IC50 68.0 nM
COc1cc(C2=NN(c3ccc(C#N)c(Cl)c3)[C@@H](C3CCCC3)[C@H]2C)ccc1C(=O)O CHEMBL1215263 IC50 69.0 nM
O=C1COc2ccc(C3=Nc4ccccc4SC3c3ccccc3)cc2N1 CHEMBL1928878 IC50 69.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3c(C#N)cccc23)C(F)(F)F)c(C)c1 CHEMBL3093452 IC50 70.0 nM
COC(=O)C(CC#N)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4777170 IC50 70.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(F)cccc3[nH]2)C1=O CHEMBL3578291 IC50 72.0 nM
NC(=O)Nc1cc(CCc2cccc(C(F)(F)F)c2)ccn1 CHEMBL3643681 IC50 73.0 nM
Cc1nn(CCCCO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337734 IC50 75.0 nM
Cc1cc(F)ccc1-n1nc(C(F)(F)F)cc1-c1cc(F)c2c(c1)NC(=O)CO2 CHEMBL1929040 IC50 76.0 nM
NC(=O)Nc1cc(CCc2ccccc2F)ccn1 CHEMBL3643685 IC50 76.0 nM
COC(=O)C1=C(C)NC(C)=C(C#N)[C@H]1c1ccnc2ccccc12 CHEMBL1097753 IC50 77.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccc(F)cc1Cl CHEMBL1215260 IC50 78.0 nM
Cc1cccc(CCc2ccnc(NC(N)=O)c2)c1 CHEMBL3643682 IC50 78.0 nM
CC1=CC(C)(C)Nc2ccc3c(c21)COc1ccc([N+](=O)[O-])cc1-3 CHEMBL64294 Efficacy 79.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL415621 Ki 80.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)c(OC(F)(F)F)c3)C[C@@H]2C2CCCC2)cc1Cl CHEMBL1215199 IC50 80.0 nM
Cc1ccccc1-n1nc(C(F)(F)F)cc1-c1ccc2c(c1)NC(=O)CO2 CHEMBL1929036 IC50 80.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3cccc(C)c23)C(F)(F)F)c(C)c1 CHEMBL3093445 IC50 80.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3ccccc23)C(F)(F)F)c(C)c1 CHEMBL3093443 IC50 80.0 nM
O=S(=O)(NC(Cc1c[nH]c2ccccc12)C(F)(F)F)c1c(Cl)cc(Cl)cc1Cl CHEMBL3093442 IC50 80.0 nM
CCCn1nc(C)c(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1 CHEMBL3337730 IC50 81.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2nnc(C3(c4ccccc4)CC3)o2)C1=O CHEMBL3234863 IC50 82.0 nM
CN(C)CCN(C)C(=O)c1ccc(C2=NN(c3ccc(C#N)cc3)C(c3ccc(F)cc3)C2)cc1 CHEMBL1215755 IC50 83.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cnncc2[nH]1)C(F)(F)F CHEMBL3126951 IC50 83.0 nM
NC(=O)Nc1cc(CCc2cccc(F)c2)ccn1 CHEMBL3643669 IC50 86.0 nM
CC1(C)CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccccc2)CO1 CHEMBL4082524 IC50 86.0 nM
COc1ccc(C(c2ccccc2)c2c[nH]c3ccccc23)cc1 CHEMBL1672540 Ki 86.8 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCCC2)cc1 CHEMBL1215485 IC50 89.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3c(C)cccc23)C(F)(F)F)c(C)c1 CHEMBL3093448 IC50 90.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3ccc(C)cc23)C(F)(F)F)c(C)c1 CHEMBL3093446 IC50 90.0 nM
COc1ccc(C)c(C(C)(C)CC(O)(Cn2ccc(=O)c3ccccc32)C(F)(F)F)c1 CHEMBL219561 IC50 91.0 nM
COC(=O)C1=C(C)NC(C)=C(C#N)C1c1ccc(F)cc1Cl CHEMBL1215403 IC50 92.0 nM
CC1NC(=O)C(c2ccc(F)cc2)=C1c1cc(F)c2c(c1)NC(=O)CO2 CHEMBL2419299 IC50 92.0 nM
C[C@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@]21C=CCO1 CHEMBL3692346 IC50 92.0 nM
CC1NC(=O)C(c2ccc(F)cc2)=C1c1ccc2c(c1)NC(=O)CO2 CHEMBL2419298 IC50 94.0 nM
Cc1nn(CCC(F)(F)CO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337832 IC50 95.0 nM
CC[C@](C(=O)NCC(F)(F)F)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4776613 IC50 97.0 nM
CC(C)(CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F)c1cccc2c1OCC2 CHEMBL373497 IC50 98.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)Nc2ccc(C#N)cc2)C1=O CHEMBL2407684 IC50 100.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)Nc2ccc(F)cc2)C1=O CHEMBL2407682 IC50 100.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cn2ccc3c(C#N)cccc32)C(F)(F)F)c(C)c1 CHEMBL3093457 IC50 100.0 nM
NC(=O)Nc1cc(CC(c2ccccc2)C2CC2)ccn1 CHEMBL3643678 IC50 100.0 nM
NC(=O)Nc1cc(CCc2ccc(C(F)(F)F)cc2)ccn1 CHEMBL3643689 IC50 100.0 nM
CCOc1nccc2c1C(c1ccc(C#N)cc1OC)C(C#N)=C(C)N2 CHEMBL4089197 IC50 100.0 nM
CNC(=O)C[C@H]1COc2ccc(Cl)cc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4462110 pKi 100.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)C[C@@H]2c2ccc(F)cc2)cc1 CHEMBL1214685 IC50 101.0 nM
Cc1noc(=O)c2ccc(NC(=O)C(O)(CC3CCCCC3)CC(C)(C)c3cc(F)ccc3O)cc12 CHEMBL195962 IC50 104.0 nM
Cc1noc(=O)c2ccc(NC(=O)C(O)(Cc3ccccc3)CC(C)(C)c3cc(F)ccc3O)cc12 CHEMBL372102 IC50 104.0 nM
C[C@@H]1CN(c2cc3c(cn2)OCC(=O)N3)[C@H](c2ccccc2)CO1 CHEMBL4098088 IC50 109.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3c(C#N)cc(C)cc23)C(F)(F)F)c(C)c1 CHEMBL3093453 IC50 110.0 nM
CCC(Cc1ccc(O)c2ccccc12)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094485 IC50 110.0 nM
Cc1nn(C)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337726 IC50 110.0 nM
NC(=O)Nc1cc(-c2ocnc2-c2ccc(F)cc2)ccn1 CHEMBL3643696 IC50 110.0 nM
CC[C@]12CC[C@H]3[C@@H](C[C@@H](CO)C4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@]21C=CCO1 CHEMBL3692357 IC50 110.0 nM
Cc1cn(-c2ccc(CNS(=O)(=O)c3cc(F)ccc3F)cc2)c(C)n1 CHEMBL3086027 Ki 113.0 nM
C[C@@H]1CN(c2ncc3c(n2)NC(=O)CO3)[C@H](c2ccccc2)CO1 CHEMBL4079143 IC50 113.0 nM
CCC(CC)(c1ccc(Cl)cc1)n1ncc2c(NS(C)(=O)=O)cccc21 CHEMBL4435726 IC50 114.0 nM
CC[C@](C(=O)NC)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4563704 IC50 115.0 nM
Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCCCC(=O)NCCCC(=O)O)c2)cc1 CHEMBL185265 IC50 120.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F CHEMBL386465 IC50 120.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F CHEMBL216173 IC50 120.0 nM
CC1OC(=O)C(c2ccc(F)cc2)=C1c1ccc2c(c1)NC(=O)CO2 CHEMBL2419306 IC50 120.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cn2ccc3ccccc32)C(F)(F)F)c(C)c1 CHEMBL3093454 IC50 120.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4ccccn4)ccc3[nH]2)C1=O CHEMBL3578287 IC50 120.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-c4cc[nH]n4)ccc3[nH]2)C1=O CHEMBL3576885 IC50 120.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(-n4cnnn4)ccc3[nH]2)C1=O CHEMBL3578280 IC50 120.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(C(F)(F)F)ccc3[nH]2)C1=O CHEMBL3578274 IC50 120.0 nM
Cc1cc(C)c(S(=O)(=O)NCc2ccc(-n3ccnc3C)cc2)c(C)c1 CHEMBL3086020 IC50 121.0 nM
COC(=O)C1=C(Cn2cncn2)NC(C)=C(C#N)C1c1ccc(F)cc1Cl CHEMBL1215621 IC50 123.0 nM
COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)C2C1C1CC[C@@]3(CCC(=O)O3)[C@@]1(C)[C@H]1O[C@@H]21 CHEMBL237122 Ki 124.0 nM
C[C@H]1CCc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4440099 pKi 125.89 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc([N+](=O)[O-])c1 CHEMBL1095098 IC50 126.0 nM
Cc1cc(-c2cn(C(C)C)c3cc(NS(C)(=O)=O)ccc23)ccc1C#N CHEMBL1672541 Ki 126.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2C=CC=CO2)cc1Cl CHEMBL1215411 IC50 127.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(CN1CCC(=O)c2ccccc21)C(F)(F)F CHEMBL219314 IC50 130.0 nM
CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl CHEMBL396029 IC50 130.0 nM
CC1(C)OC(=S)Nc2ccc(NS(=O)(=O)c3cccs3)cc21 CHEMBL2181930 IC50 130.0 nM
COc1cc(OC)nc(-c2nnc([C@@]3(Cc4ccccc4)OC(=O)N([C@H](C)c4ccccc4)C3=O)o2)n1 CHEMBL3234861 IC50 130.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(Cl)cccc3[nH]2)C1=O CHEMBL3578292 IC50 130.0 nM
NC(=O)Nc1cc(-c2cc(C(F)(F)F)nn2-c2ccccc2)ccn1 CHEMBL3643646 IC50 130.0 nM
Cn1cnc(-c2ccc(F)cc2)c1-c1ccnc(NC(N)=O)c1 CHEMBL3643692 IC50 130.0 nM
N#Cc1ccc(N2N=C(c3ccc(CC(=O)O)cc3)C[C@@H]2C2CCCC2)cc1Cl CHEMBL1215262 IC50 135.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL407672 Ki 140.0 nM
CC(C)(CC(O)(CC1CCCCC1)C(=O)Nc1ccc2c(c1)COC2=O)c1cc(F)ccc1O CHEMBL194802 IC50 140.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3cc(C)ccc23)C(F)(F)F)c(C)c1 CHEMBL3093447 IC50 140.0 nM
NC(=O)Nc1cc(C2=C(c3ccc(F)cc3)CCCC2)ccn1 CHEMBL3643698 IC50 140.0 nM
O=C1COc2ccc(C#Cc3ccc(F)cc3F)cc2N1 CHEMBL3775577 Ki 144.0 nM
Cc1cc(-c2cc(F)c(F)c3cc[nH]c23)c(Cl)c2c1NC(C)(C)CC2C CHEMBL429842 Ki 145.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CO[C@H]3[C@H]2C2CCCC2)cc1Cl CHEMBL1215624 IC50 146.0 nM
CS(=O)(=O)Nc1ccc(N(Cc2ccccc2)c2ccccc2)cc1 CHEMBL5181002 Ki 147.0 nM
COc1c(O)ccc2c1-c1ccc3c(c1/C(=C/c1cccc(C)c1F)O2)C(C)=CC(C)(C)N3 CHEMBL259820 Ki 149.0 nM
CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C CHEMBL1473 IC50 149.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOCCO[C@H]4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL2096708 Ki 150.0 nM
Cc1ccccc1C(C)(C)CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F CHEMBL425970 IC50 150.0 nM
COCc1cc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCCC2)ccc1C#N CHEMBL1215488 IC50 150.0 nM
CCC(Cc1cc(Cl)cc(Cl)c1)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094478 IC50 150.0 nM
Cc1cc(-c2c(C)nn(C)c2-c2ccc(F)cc2)cc2c1OCC(=O)N2 CHEMBL3337728 IC50 150.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(-c4cnn(C)c4)cccc3[nH]2)C1=O CHEMBL3578298 IC50 150.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(C(F)(F)F)cccc3[nH]2)C1=O CHEMBL3578293 IC50 150.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2C2CCCC2)cc1 CHEMBL1215052 IC50 151.0 nM
CS(=O)(=O)Nc1ccc2c(c1)OC1(CCC1)C(=O)N2c1ccc(F)cc1 CHEMBL5187656 Ki 152.0 nM
COc1ccc2cc[nH]c2c1-c1cc(C)c2c(c1Cl)C(C)CC(C)(C)N2 CHEMBL253745 Ki 155.0 nM
Cn1c(C#N)ccc1-c1ccc2c(c1)C(C)(c1ccco1)OCC(=O)N2 CHEMBL489788 IC50 155.0 nM
O=C(O)C[C@H]1COc2cc(Cl)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4519264 pKi 158.49 nM
CC(C)(CC(O)(Cc1ccccc1)C(=O)Nc1ccc2c(c1)COC2=O)c1ccccc1 CHEMBL197161 IC50 160.0 nM
Cc1ccc(O)c(C(C)(C)CC(O)(Cn2ccc(=O)c3ccccc32)C(F)(F)F)c1 CHEMBL384081 IC50 160.0 nM
CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cc(-c2ccccc2)ccc1O CHEMBL1254265 IC50 160.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cncnc2[nH]1)C(F)(F)F CHEMBL3126954 IC50 160.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2nnc(Cc3ccccc3)o2)C1=O CHEMBL3234856 IC50 160.0 nM
Cc1cccc(-n2nccc2-c2ccnc(NC(N)=O)c2)c1 CHEMBL3643657 IC50 160.0 nM
COc1ccc(CCc2ccnc(NC(N)=O)c2)cc1 CHEMBL3643688 IC50 160.0 nM
CC1=C(C#N)C(c2cccc3c(=O)cc(C)oc23)C(C(=O)OC(C)C)=C(C)N1 CHEMBL4084504 IC50 160.0 nM
CC1Oc2cc(NS(C)(=O)=O)ccc2N(c2ccc(F)cc2)C1=O CHEMBL5174401 Ki 160.0 nM
CS(=O)(=O)Nc1ccc2c(c1)C(c1ccccc1)Oc1cccc(OC(F)F)c1-2 CHEMBL65221 IC50 162.0 nM
O=C1COc2ccc(/C=C/c3ccc(F)cc3F)cc2N1 CHEMBL3775732 Ki 162.0 nM
CC1(C)CN(c2ccc(F)cc2)c2ccc(NS(C)(=O)=O)cc2O1 CHEMBL5181278 Ki 163.0 nM
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)SCF CHEMBL1676 IC50 166.0 nM
Cc1nccn1-c1ccc(CNS(=O)(=O)c2cc(F)ccc2F)cc1F CHEMBL3086026 IC50 168.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOCCO[C@@H]4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL2096804 Ki 170.0 nM
CC(C)(CC(O)(CC1CCCCC1)C(=O)Nc1ccc2c(c1)COC2=O)c1ccccc1 CHEMBL363137 IC50 170.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N(C3CCCc4ccccc43)C2=O)cc(OC)c1 CHEMBL2407648 IC50 170.0 nM
CC1C(c2ccc3c(c2)NC(=O)CO3)=C(c2ccc(F)cc2)C(=O)N1C CHEMBL2419309 IC50 170.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3cccc(C#N)c23)C(F)(F)F)c(C)c1 CHEMBL3093449 IC50 170.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2nc(N3CCOCC3)ncc2[nH]1)C(F)(F)F CHEMBL3126938 IC50 170.0 nM
Cn1ncc(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1 CHEMBL3337725 IC50 170.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(-c4cccnc4)cccc3[nH]2)C1=O CHEMBL3578299 IC50 170.0 nM
CC(C)(C)c1ccc(CC(O)(CC(C)(C)c2ccccc2)C(=O)Nc2ccc3c(c2)COC3=O)cc1 CHEMBL196237 IC50 175.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cn1ccc(=O)c2cnccc21)C(F)(F)F CHEMBL386916 IC50 175.0 nM
CCOC(=O)c1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccc(F)cc2)cc1 CHEMBL1214688 IC50 180.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccc(F)cc2)(C(=O)NCc2ccc(Cl)c(Cl)c2)C1=O CHEMBL2407651 IC50 180.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)Nc2ccc(Cl)cc2)C1=O CHEMBL2407679 IC50 180.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(OC(F)(F)F)ccc3[nH]2)C1=O CHEMBL3578275 IC50 180.0 nM
CNC(=O)CC1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3986656 IC50 180.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCCC(=O)N(C)C4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL408376 Ki 190.0 nM
CC(C)(CC(O)(Cc1ccccc1)C(=O)Nc1ccc2c(c1)COC2=O)c1cc(F)ccc1O CHEMBL196051 IC50 190.0 nM
COc1ccc(F)cc1C(C)(C)C[C@@](O)(Cc1cc2ccccc2[nH]1)C(F)(F)F CHEMBL1911542 IC50 190.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)N[C@H]2C[C@H](c3ccccc3)C2)C1=O CHEMBL2407854 IC50 190.0 nM
CCC(Cc1cccc2ccccc12)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094479 IC50 190.0 nM
Cc1nn(C)c(-c2ccc(F)cc2F)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337727 IC50 190.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3ccccc3[nH]2)C1=O CHEMBL3578272 IC50 190.0 nM
NC(=O)Nc1cc(-c2ccnn2-c2cccc(Cl)c2)ccn1 CHEMBL3643659 IC50 190.0 nM
NC(=O)Nc1cc(-c2ccnn2-c2ccc(F)cc2Cl)ccn1 CHEMBL3643667 IC50 190.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(CNc1ccc2c(c1)COC2=O)Cc1ccccc1 CHEMBL197100 IC50 195.0 nM
O=C1COc2ccc(N3CCc4ccc(F)cc4CC3)cc2N1 CHEMBL4081132 Ki 195.7 nM
O=C1COc2ccc(C(=O)N3c4ccc(F)cc4OC[C@@H]3CCO)cc2N1 CHEMBL4459932 pKi 199.53 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccc(F)cc3)OC(=O)N([C@H](C)c3ccccc3)C2=O)cc(OC)c1 CHEMBL2407873 IC50 200.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)NCc2ccc(Cl)cc2)C1=O CHEMBL2407669 IC50 200.0 nM
COC(=O)C(C)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4790021 IC50 200.0 nM
COC(=O)C(c1ccc(F)cc1Cl)n1ccc2c(C#N)cccc21 CHEMBL4746794 IC50 200.0 nM
CC1=C(C#N)C(c2ccc(F)cc2F)C(C(=O)OC(C)(C)C)=C(C)N1 CHEMBL1215327 IC50 201.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccccc1C CHEMBL1215048 IC50 208.0 nM
COC(=O)C1=C(C(C)C)NC(C)=C(C#N)C1c1ccccc1Cl CHEMBL1215407 IC50 208.0 nM
CC(C)(C[C@@](O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cc(F)ccc1O CHEMBL1253898 IC50 210.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3ccc(C#N)cc23)C(F)(F)F)c(C)c1 CHEMBL3093450 IC50 210.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(NS(C)(=O)=O)cccc3[nH]2)C1=O CHEMBL3578295 IC50 210.0 nM
CC(C)(CC(O)(C(=O)Nc1ccc2c(c1)COC2=O)C(F)(F)F)c1ccccc1 CHEMBL196067 IC50 215.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc(C)cc(C)c1)C(F)(F)F CHEMBL393392 IC50 220.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccncc2s1)C(F)(F)F CHEMBL1254907 IC50 220.0 nM
CC(C)(C[C@@](O)(Cc1cc2cnccc2[nH]1)C(F)(F)F)c1cc(F)ccc1O CHEMBL1253899 IC50 220.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cn2ccc3ncccc32)C(F)(F)F)c(C)c1 CHEMBL3093455 IC50 220.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(NS(C)(=O)=O)ccc3[nH]2)C1=O CHEMBL3578276 IC50 220.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@H]3[C@H]2c2ccc(F)cc2)cc1Cl CHEMBL1215329 IC50 223.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccccc1C(F)(F)F CHEMBL1215047 IC50 224.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2c(C#N)cccc2[nH]1)C(F)(F)F CHEMBL1911644 IC50 225.0 nM
CS(=O)(=O)Nc1cccc2c(-c3ccc(F)cc3)c[nH]c12 CHEMBL3605934 Ki 225.0 nM
CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cc(-c2cccnc2)ccc1O CHEMBL1254344 IC50 230.0 nM
CC(C)(C[C@@](O)(Cc1cc2ccc(C#N)cc2[nH]1)C(F)(F)F)c1cc(S(C)(=O)=O)cc2c1OCC2 CHEMBL1911664 IC50 230.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(-c4ccncc4)cccc3[nH]2)C1=O CHEMBL3578300 IC50 230.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(F)ccc3[nH]2)C1=O CHEMBL3578273 IC50 230.0 nM
CN(Cc1ccc2c(c1)NC(=O)CO2)c1ccc(F)cc1F CHEMBL3775291 Ki 230.0 nM
CNC(=O)CC1COc2ccccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3957890 IC50 230.0 nM
CCC1=C(C(=O)OC)C(c2ccccc2Cl)C(C#N)=C(C)N1 CHEMBL1215405 IC50 232.0 nM
Cc1cc2c(c(C(C)(C)CC(O)(Cc3cc4ccccc4[nH]3)C(F)(F)F)c1)OCC2 CHEMBL1911657 IC50 240.0 nM
CCC(Cc1ccc(O)c(C)c1C)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094482 IC50 240.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2ncc(Cc3ccccc3)o2)C1=O CHEMBL3234847 IC50 240.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2ncc(-c3ccccc3)[nH]2)C1=O CHEMBL3234848 IC50 240.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccc(F)cc2)cc1F CHEMBL1214766 IC50 243.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccc(F)cc2)cc1 CHEMBL1215758 IC50 246.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc(C)cc(C)c1C#N)C(F)(F)F CHEMBL392501 IC50 250.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C1=O CHEMBL2407855 IC50 250.0 nM
Cc1nn(CCNS(C)(=O)=O)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337827 IC50 250.0 nM
CC1(C)Oc2cc(NS(C)(=O)=O)ccc2N(c2ccc(F)cc2)C1=O CHEMBL2181929 IC50 256.0 nM
O=C1COc2ccc(/C=C\c3ccc(F)cc3F)cc2N1 CHEMBL3774738 Ki 258.0 nM
O=C1COc2ccc(-c3cc(C(F)(F)F)nn3-c3ccc(F)cc3)cc2N1 CHEMBL1928884 IC50 260.0 nM
CC[C@@H](Cn1cc(C)c2ccccc21)NS(=O)(=O)c1c(N)cc(Cl)cc1Cl CHEMBL3093462 IC50 260.0 nM
Cc1cc(C)c(S(=O)(=O)NC(CNc2ccccc2)C(F)(F)F)c(C)c1 CHEMBL3093458 IC50 260.0 nM
Cc1ccc(F)cc1C(C)(C)C[C@@](O)(Cc1cc2nnccc2[nH]1)C(F)(F)F CHEMBL3126948 IC50 260.0 nM
CC(C)(CC(O)(Cc1cc2ccccc2[nH]1)C(F)(F)F)c1cc(F)cc2c1OCC2 CHEMBL1911656 IC50 265.0 nM
O=C1COc2ccc(C3=Nn4cnnc4SC3c3ccc(F)cc3)cc2N1 CHEMBL1928876 IC50 270.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)Nc2ccccc2)C1=O CHEMBL2407678 IC50 270.0 nM
Nc1cc(Cl)cc(Cl)c1S(=O)(=O)NC(Cc1c[nH]c2ccccc12)C(F)(F)F CHEMBL3093441 IC50 270.0 nM
CC[C@@H](Cc1ccc(O)c(C)c1C)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094468 IC50 270.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2ncc(Cc3ccccc3)[nH]2)C1=O CHEMBL3234849 IC50 270.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2nnc(-c3cc(F)cc(F)c3)o2)C1=O CHEMBL3234859 IC50 270.0 nM
NC(=O)Nc1cc(C2CCCCC2c2ccc(F)cc2)ccn1 CHEMBL3643699 IC50 270.0 nM
NC(=O)CC1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL3939447 IC50 270.0 nM
COC(=O)C1=C(C(F)(F)F)N(C)C(C)=C(C#N)C1c1ccc(F)cc1Cl CHEMBL1215551 IC50 275.0 nM
COC(=O)C(Cc1ccccc1)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4755269 IC50 275.0 nM
COC[C@@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccccc2)CO1 CHEMBL4059632 IC50 276.0 nM
CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cc(F)cc2c1OCC2 CHEMBL1254420 IC50 280.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3cccc(F)c3)OC(=O)N([C@H](C)c3ccccc3)C2=O)cc(OC)c1 CHEMBL2407874 IC50 280.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)NCc2cccc(Cl)c2)C1=O CHEMBL2407670 IC50 280.0 nM
Cc1cc(C)c(S(=O)(=O)NC(CSc2ccccc2)C(F)(F)F)c(C)c1 CHEMBL3093460 IC50 280.0 nM
Cc1cc(C)c(S(=O)(=O)NC(Cc2c[nH]c3cc(C#N)ccc23)C(F)(F)F)c(C)c1 CHEMBL3093451 IC50 280.0 nM
Cc1ccccc1-n1nccc1-c1ccnc(NC(N)=O)c1 CHEMBL3643651 IC50 280.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccc(F)cc2)c(Cl)c1 CHEMBL1214840 IC50 284.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccc(F)cc1 CHEMBL1215195 IC50 288.0 nM
Cc1cc(C)c(S(=O)(=O)NC(C)Cc2c[nH]c3ccccc23)c(C)c1 CHEMBL232452 IC50 290.0 nM
COc1c(O)ccc2c1-c1ccc3c(c1/C(=C/c1cccc(O)c1)O2)C(C)=CC(C)(C)N3 CHEMBL3706946 Ki 290.0 nM
Cc1cc(C)c(S(=O)(=O)N[C@@H](C)Cc2c[nH]c3ccccc23)c(C)c1 CHEMBL395795 IC50 290.0 nM
COc1ccccc1C1CCN(c2[nH]c(=O)[nH]c(=O)c2Cc2ccccc2)CC1 CHEMBL231296 Ki 298.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCCS(=O)(=O)N(C)C4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL406027 Ki 300.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc(C)c(C#N)c(C)c1)C(F)(F)F CHEMBL236755 IC50 300.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3F)OC(=O)N([C@H](C)c3ccccc3)C2=O)cc(OC)c1 CHEMBL2407875 IC50 300.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)NCc2cccc3ccnn23)C1=O CHEMBL2407865 IC50 300.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)Nc2cccc(F)c2)C1=O CHEMBL2407683 IC50 300.0 nM
COc1cccc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N([C@H](C)c3ccccc3)C2=O)c1 CHEMBL2407664 IC50 300.0 nM
NC(=O)Nc1cc(-c2ccnn2-c2ccccc2F)ccn1 CHEMBL3643664 IC50 300.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccc(C(F)(F)F)cc1 CHEMBL1215193 IC50 309.0 nM
Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccccc1 CHEMBL419633 IC50 310.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C(=O)CNC(=O)OC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL411185 Ki 310.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCNC(=O)O[C@@H]4C[C@@H]5CC(O)CC[C@]5(C)[C@H]5C[C@H](O)[C@]6(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@H]6[C@H]45)cc3)C[C@@]21C CHEMBL414041 Ki 310.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(CN1CCOc2ccccc21)C(F)(F)F CHEMBL386915 IC50 310.0 nM
O=C1COc2ccc(C3=Nn4cnnc4SC3c3cccc(F)c3)cc2N1 CHEMBL1928875 IC50 310.0 nM
NC(=O)Nc1cc(-c2ccnn2-c2cccc(F)c2)ccn1 CHEMBL3643663 IC50 310.0 nM
CC[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34C=CCO4)[C@H]12 CHEMBL3692348 IC50 310.0 nM
CCc1cnc2cccc(C3C(C#N)=C(C)NC(C)=C3C(=O)OC(C)C)c2c1 CHEMBL4081044 IC50 310.0 nM
CC(C)C(O)(CC(C)(C)c1ccccc1)C(=O)Nc1ccc2c(c1)COC2=O CHEMBL196373 IC50 315.0 nM
CNC(=O)C[C@H]1CCc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4590259 pKi 316.23 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccc(Cl)cc1 CHEMBL1215259 IC50 319.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C#N)cc1Cl)C(F)(F)F CHEMBL235063 IC50 320.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cnccc2[nH]1)C(F)(F)F CHEMBL1254735 IC50 320.0 nM
O=C1COc2ccc(-c3cc(C(F)(F)F)nn3-c3ccc(Cl)cc3)cc2N1 CHEMBL1929035 IC50 320.0 nM
CCC(Cc1cc(C)ccc1C)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094475 IC50 320.0 nM
CC1=C(C#N)C(c2ccc(F)cc2)C(C(=O)OC(C)(C)C)=C(C)N1 CHEMBL1215325 IC50 329.0 nM
CC[C@@H](Cn1cc(C#N)c2ccccc21)NS(=O)(=O)c1c(N)cc(Cl)cc1Cl CHEMBL3093463 IC50 330.0 nM
CCC(Cc1ccc(OC)c(C)c1C)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094481 IC50 330.0 nM
NC(=O)Nc1cc(CCc2ccc(F)c(C(F)(F)F)c2)ccn1 CHEMBL3643691 IC50 330.0 nM
COc1ccc(Cn2cnc(-c3ccc(F)cc3)c2-c2ccnc(NC(N)=O)c2)c(OC)c1 CHEMBL3643693 IC50 330.0 nM
CC[C@@](C(=O)OC)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4749536 IC50 330.0 nM
COc1cccc2c1-c1ccc(NS(C)(=O)=O)cc1C(c1cccc(C)c1)O2 CHEMBL294800 IC50 333.0 nM
CCc1ccccc1/C=C1\Oc2ccc(F)cc2-c2ccc3c(c21)C(C)=CC(C)(C)N3 CHEMBL415524 IC50 334.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(C)(C)C(=O)C(C)(C)N2 CHEMBL3582109 Ki 337.0 nM
COC(=O)C1=C(CCl)NC(C)=C(C#N)[C@H]1c1ccnc2ccccc12 CHEMBL1094798 IC50 340.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)N2CCc3ccccc3C2)C1=O CHEMBL2407659 IC50 340.0 nM
Cc1cc(C)c(S(=O)(=O)NC(COc2ccccc2)C(F)(F)F)c(C)c1 CHEMBL3093459 IC50 340.0 nM
CC(C)(CC(O)(Cc1cc2ncncc2[nH]1)C(F)(F)F)c1cc(Cl)cc2c1OCC2 CHEMBL3126945 IC50 340.0 nM
Cc1nccn1-c1ccc(CNS(=O)(=O)c2ccccc2Cl)cc1 CHEMBL3086022 IC50 342.0 nM
CS(=O)(=O)Nc1ccc2c(c1)OC(c1ccccc1)C(=O)N2c1ccc(F)cc1 CHEMBL5171957 Ki 342.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C=O)cc1Cl)C(F)(F)F CHEMBL392289 IC50 345.0 nM
CC(C)(CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F)c1ccccc1 CHEMBL219069 IC50 350.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccc(F)cc2[nH]1)C(F)(F)F CHEMBL1911651 IC50 350.0 nM
CCC(Cc1cccc(C)c1C)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094473 IC50 350.0 nM
CC1=CC(C)(C)Nc2ccc3c(c21)C(c1ccccc1)Oc1ccccc1-3 CHEMBL101914 IC50 354.0 nM
Cc1noc(C)c1S(=O)(=O)NCc1ccc(-c2ccccc2)cc1 CHEMBL1645393 IC50 356.0 nM
CCC(Cc1cc(C)cc(C)c1)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094476 IC50 360.0 nM
C[C@]12CCC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12 CHEMBL27769 IC50 360.0 nM
CC1=CC(C)(C)Nc2ccc3c(c21)/C(=C/c1ccncc1C)Oc1ccc(F)cc1-3 CHEMBL130141 IC50 363.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(-c4cncnc4)cccc3[nH]2)C1=O CHEMBL3578301 IC50 370.0 nM
CC(C)NC(=O)O[C@@H]1[C@@H](C)c2c(cc(F)c(-c3cccc4c(Cl)c[nH]c34)c2F)NC1(C)C CHEMBL1684343 Ki 378.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccccc2[nH]1)C(F)(F)F CHEMBL1254651 IC50 380.0 nM
COc1ccc(F)cc1C(C)(C)C[C@@](O)(Cc1cc2ccncc2[nH]1)C(F)(F)F CHEMBL1255080 IC50 380.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2nnc(-c3ccccc3)o2)C1=O CHEMBL3234855 IC50 380.0 nM
CC(C)C1CC(c2ccc(C(=O)O)cc2)=NN1c1ccc(C#N)c(Cl)c1 CHEMBL1215053 IC50 383.0 nM
COc1ccc(-c2ccncc2)cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F CHEMBL1254173 IC50 390.0 nM
CNC(=O)C[C@H]1COc2cc(Cl)cc(C)c2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4474698 pKi 398.11 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cccc(C#N)c1)C(F)(F)F CHEMBL401219 IC50 400.0 nM
CC(C)(CC(O)(Cc1cc2ccccc2[nH]1)C(F)(F)F)c1cccc2c1OCC2 CHEMBL1911655 IC50 400.0 nM
CC[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)NCc2cc(OC)cc(OC)c2)C1=O CHEMBL2407649 IC50 400.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)N[C@H](C)c2cccc(Cl)c2)C1=O CHEMBL2407671 IC50 400.0 nM
CCC(Cc1ccc2ccccc2c1)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094480 IC50 400.0 nM
CCC(Cc1cc(F)cc(F)c1)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094477 IC50 400.0 nM
CCC(Cc1cccc(C)c1)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094470 IC50 400.0 nM
CNC(=O)c1ccc2[nH]c([C@@]3(Cc4ccccc4)OC(=O)N([C@H](C)c4ccc(F)cc4)C3=O)nc2c1 CHEMBL3578278 IC50 400.0 nM
O=C1COc2ccc(N3CCOC[C@H]3c3ccccc3)cc2N1 CHEMBL4062345 IC50 401.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cc(F)ccc2[nH]1)C(F)(F)F CHEMBL1911646 IC50 405.0 nM
CC(C)(CC(O)(Cc1cc2ccccc2[nH]1)C(F)(F)F)c1cc(C#N)cc2c1OCC2 CHEMBL1911659 IC50 405.0 nM
CC(C)(C[C@](O)(Cc1cc2ccc(C#N)cc2[nH]1)C(F)(F)F)c1cc(S(C)(=O)=O)cc2c1OCC2 CHEMBL1911663 IC50 405.0 nM
COc1c(O)ccc2c1-c1ccc3c(c1/C(=C/c1sccc1C(C)O)O2)C(C)=CC(C)(C)N3 CHEMBL244537 Ki 410.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccco2)cc1 CHEMBL1214968 IC50 410.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2c(C)cccc2[nH]1)C(F)(F)F CHEMBL1911548 IC50 415.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cc(C#N)ccc2[nH]1)C(F)(F)F CHEMBL1911649 IC50 415.0 nM
Cc1c(N[C@@H]2CCCC[C@@]2(C)O)ccc(C#N)c1Cl CHEMBL3765823 Ki 415.0 nM
Cc1ccc(F)cc1C(C)(C)C[C@@](O)(Cc1cc2cnccc2[nH]1)C(C)(C)C CHEMBL3233281 IC50 420.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3cc(C#N)ccc3[nH]2)C1=O CHEMBL3578279 IC50 420.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(CN1C[C@@H](C)C(=O)[C@@H](C)C1)C(F)(F)F CHEMBL216273 IC50 430.0 nM
COCOCc1cc(F)ccc1/C=C1\Oc2ccc(O)c(OC)c2-c2ccc3c(c21)C(C)=CC(C)(C)N3 CHEMBL3706942 Ki 430.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C#N)c2ccccc12)C(F)(F)F CHEMBL392500 IC50 430.0 nM
CC(C)(CC(O)(Cc1cc2ccc(C#N)cc2[nH]1)C(F)(F)F)c1cc(S(C)(=O)=O)cc2c1OCC2 CHEMBL1911662 IC50 430.0 nM
O=C1COc2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3Cl)cc2N1 CHEMBL1929034 IC50 430.0 nM
Cc1nn(Cc2ccncc2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337822 IC50 430.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cccc(F)c2[nH]1)C(F)(F)F CHEMBL1911544 IC50 435.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccc(C#N)cc2[nH]1)C(F)(F)F CHEMBL1911654 IC50 435.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL427568 Ki 440.0 nM
Cn1c(C#N)ccc1-c1ccc2c(c1)C(C)(c1ccsc1)OCC(=O)N2 CHEMBL522432 IC50 440.0 nM
O=C1COc2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3F)cc2N1 CHEMBL1929032 IC50 440.0 nM
Cc1nn(CCCO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337733 IC50 440.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2cccc(F)c2)cc1 CHEMBL1214971 IC50 441.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(CN1C[C@@H](C)O[C@@H](C)C1)C(F)(F)F CHEMBL375348 IC50 450.0 nM
CC(C)(CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F)c1ccccc1O CHEMBL375838 IC50 450.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1c(C)ccc2ccccc12)C(F)(F)F CHEMBL236754 IC50 450.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3Cl)OC(=O)N([C@H](C)c3ccccc3)C2=O)cc(OC)c1 CHEMBL2407638 IC50 450.0 nM
COc1cccc2c1-c1ccc(NS(C)(=O)=O)c(Br)c1C(c1ccccc1)O2 CHEMBL63768 IC50 454.0 nM
O=[N+]([O-])c1ccc(N2N=C(c3ccc(O)cc3)CC2c2ccc(F)cc2)cc1 CHEMBL1215689 IC50 460.0 nM
COC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1ccnc2ccccc12 CHEMBL1097752 IC50 469.0 nM
CN(C)c1ccc([C@H]2C[C@]3(C)[C@@H](CC[C@]3(O)CCCO)[C@@H]3CCC4=CC(=O)CCC4=C32)cc1 CHEMBL1908373 IC50 470.0 nM
CC(C)(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(N)cc(Cl)cc1Cl CHEMBL3093444 IC50 470.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2nnc(CC3CC3)o2)C1=O CHEMBL3234862 IC50 470.0 nM
Cc1ccc(F)cc1C(C)(C)C[C@@](O)(Cc1cc2ncncc2[nH]1)C(F)(F)F CHEMBL3126949 IC50 475.0 nM
COc1ccc(-c2ccccc2)cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F CHEMBL1254080 IC50 480.0 nM
CCC(Cc1cc(C)c(O)c(C)c1)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094484 IC50 480.0 nM
Cc1ccc(CCc2ccnc(NC(N)=O)c2)cc1 CHEMBL3643670 IC50 480.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCCC2)cc1OCc1ccccc1 CHEMBL1215553 IC50 488.0 nM
Cc1nn(CCC#N)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337828 IC50 490.0 nM
COc1cccc2c1-c1ccc3c(c1C(c1cccc(C(F)(F)F)c1)O2)C(C)=CC(C)(C)N3 CHEMBL95644 Ki 493.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C#N)cc1F)C(F)(F)F CHEMBL400609 IC50 500.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N([C@@H](C)c3ccccc3)C2=O)cc(OC)c1 CHEMBL2407643 IC50 500.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3ccccc3)OC(=O)N(C(C)C)C2=O)cc(OC)c1 CHEMBL2407642 IC50 500.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)NCc2cccc(C(F)(F)F)c2)C1=O CHEMBL2407674 IC50 500.0 nM
COc1ccccc1CNC(=O)[C@@]1(Cc2ccccc2)OC(=O)N([C@H](C)c2ccccc2)C1=O CHEMBL2407666 IC50 500.0 nM
O=C1COc2ccc(C3=C(c4ccc(F)cc4)C(=O)OC3)cc2N1 CHEMBL2419302 IC50 500.0 nM
N=C(c1ccc2c(c1)NC(=O)CO2)[C@@H](Sc1nnc[nH]1)c1ccccc1 CHEMBL4577956 pKi 501.19 nM
N#CC[C@H]1COc2ccccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4462225 pKi 501.19 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)NCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL414318 Ki 510.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C#N)cc1)C(F)(F)F CHEMBL429987 IC50 510.0 nM
O=C1COc2ccc(C3=Nn4cnnc4SC3c3ccccc3)cc2N1 CHEMBL1928872 IC50 510.0 nM
CC[C@@H](Cn1ccc2ccccc21)NS(=O)(=O)c1c(N)cc(Cl)cc1Cl CHEMBL3093461 IC50 510.0 nM
CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(N)cc(Cl)cc1Cl CHEMBL3093440 IC50 510.0 nM
CCn1nc(C)c(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1 CHEMBL3337729 IC50 510.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc(Cl)c1 CHEMBL1215124 IC50 518.0 nM
Cc1cc(C)c(S(=O)(=O)N[C@H](C)Cc2c[nH]c3ccccc23)c(C)c1 CHEMBL243863 IC50 520.0 nM
O=c1[nH]c(N2CCC(c3cccc(Cl)c3)CC2)c(Cc2ccccc2)c(=O)[nH]1 CHEMBL231399 Ki 527.0 nM
COC(=O)C(c1ccc(F)cc1Cl)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4742925 IC50 530.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc(Cl)ccc1Cl)C(F)(F)F CHEMBL237377 IC50 535.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2ccc(F)cc2)c(F)c1 CHEMBL1214767 IC50 535.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)[C@H]1c1cccc([N+](=O)[O-])c1 CHEMBL1094113 IC50 536.0 nM
CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cc(Cl)cc2c1OCC2 CHEMBL1254494 IC50 540.0 nM
CC1(F)OC(=O)C(c2ccc(F)cc2)=C1c1ccc2c(c1)NC(=O)CO2 CHEMBL2419307 IC50 550.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccccc1OC CHEMBL1215049 IC50 553.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2c2ccc(F)cc2)cc1 CHEMBL1215265 IC50 553.0 nM
CCC(CO)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cc(Br)cc21 CHEMBL4515343 IC50 567.0 nM
CC1(C)CCC[C@]2(C)c3cc4c(C(F)(F)F)cc(O)nc4cc3N[C@H]12 CHEMBL423620 IC50 570.0 nM
O=C1COc2ccc(-c3cc(C(F)(F)C(F)(F)F)nn3-c3ccc(F)cc3)cc2N1 CHEMBL1928885 IC50 570.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)NCc2ccc(C(F)(F)F)cc2)C1=O CHEMBL2407673 IC50 570.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccc(Cl)c(F)c1 CHEMBL1215261 IC50 574.0 nM
CC(C)(CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F)c1cc(F)ccc1O CHEMBL219973 IC50 580.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F CHEMBL1254734 IC50 580.0 nM
O=c1[nH]c(N2CCC(c3ccccc3)CC2)c(Cc2cccc(Cl)c2)c(=O)[nH]1 CHEMBL230989 Ki 585.0 nM
CC(C)(CC(O)(Cc1cc2ccccc2[nH]1)C(F)(F)F)c1cc(Br)cc2c1OCC2 CHEMBL1911658 IC50 585.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C(=O)CC[C@H](NC(=O)CC[C@@H](C)[C@H]4CC[C@H]5[C@@H]6[C@H](O)C[C@@H]7C[C@H](O)CC[C@]7(C)[C@H]6C[C@H](O)[C@]45C)C(=O)O)cc3)C[C@@]21C CHEMBL436859 Ki 590.0 nM
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C CHEMBL1276308 IC50 590.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F CHEMBL1254079 IC50 590.0 nM
Cc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc3c(c2)NC(=O)CO3)cc1 CHEMBL1929037 IC50 590.0 nM
COC(=O)C1=C(C)NC(C)=C(C#N)C1c1ccccc1Cl CHEMBL1215404 IC50 594.0 nM
O=C1COc2ccc(C3=Nn4cnnc4SC3c3ccccc3F)cc2N1 CHEMBL1928874 IC50 600.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)Nc2ccc3ccccc3c2)C1=O CHEMBL2407677 IC50 600.0 nM
CCN(c1ccccc1)c1ccc(NS(C)(=O)=O)cc1 CHEMBL5172350 Ki 607.0 nM
Cc1noc(C)c1S(=O)(=O)NCc1ccc(-c2ccccc2)s1 CHEMBL3086012 IC50 609.0 nM
CC(C)(CC(O)(Cc1cc2ccccc2[nH]1)C(F)(F)F)c1cc(S(C)(=O)=O)cc2c1OCC2 CHEMBL1911660 IC50 610.0 nM
CS(=O)(=O)Nc1ccc(N(C(=O)c2ccccc2)c2ccc(F)cc2)cc1 CHEMBL5184647 Ki 611.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2nnccc2[nH]1)C(F)(F)F CHEMBL3126950 IC50 615.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cn1cc(C)nc1C)C(F)(F)F CHEMBL220023 IC50 620.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1ccccc1Cl CHEMBL1215045 IC50 621.0 nM
Cc1nccn1-c1ccc(CNS(=O)(=O)c2cc(F)ccc2F)cc1 CHEMBL3086025 IC50 627.0 nM
O=C1COc2ccc(C(=O)N3CCCc4ccccc43)cc2N1 CHEMBL4580706 pKi 630.96 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cnccc2[nH]1)C(C)(C)C CHEMBL3233277 IC50 640.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(C=O)cc1)C(F)(F)F CHEMBL391917 IC50 650.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(C(=O)N[C@H]2C[C@@H](c3ccccc3)C2)C1=O CHEMBL2407853 IC50 650.0 nM
COc1cccc2c1-c1ccc(NS(C)(=O)=O)cc1C(c1ccc(C)cc1)O2 CHEMBL65868 IC50 651.0 nM
COCC1=C(C(=O)OC)C(c2ccccc2Cl)C(C#N)=C(C)N1 CHEMBL1215481 IC50 655.0 nM
C[C@H]1c2c(cc(F)c(-c3cccc4c(Cl)c[nH]c34)c2F)NC(C)(C)[C@@H]1OC(=O)NCc1ccccc1 CHEMBL1684342 Ki 656.0 nM
O=C1COc2ccc(C3=C(c4ccc(F)cc4F)C(=O)OC3)cc2N1 CHEMBL2419303 IC50 660.0 nM
C[C@H](c1ccccc1)N1C(=O)O[C@](Cc2ccccc2)(c2nnc(Cc3ccccc3)[nH]2)C1=O CHEMBL3234852 IC50 660.0 nM
CC1=C(C#N)C(C)(c2ccc(F)cc2)C(C(=O)OC(C)(C)C)=C(C)N1 CHEMBL1215326 IC50 661.0 nM
COc1c(O)ccc2c1-c1ccc3c(c1/C(=C/c1sccc1C(O)C(F)(F)F)O2)C(C)=CC(C)(C)N3 CHEMBL243656 Ki 670.0 nM
COc1cc(OC)cc(-c2nnc([C@@]3(Cc4ccccc4)OC(=O)N([C@H](C)c4ccccc4)C3=O)[nH]2)c1 CHEMBL3234854 IC50 670.0 nM
NC(=O)Nc1cc(-c2ccnn2-c2ccccc2)ccn1 CHEMBL3643649 IC50 670.0 nM
CC1=CC(C)(C)Nc2ccc3c(c21)C(=C1SCCCS1)Oc1ccc(F)cc1-3 CHEMBL65929 IC50 681.0 nM
COc1cccc2c1-c1ccc(NS(C)(=O)=O)cc1C(c1cccc(F)c1)O2 CHEMBL65354 IC50 683.0 nM
Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2ccc(OCC(=O)O)cc2)cc1 CHEMBL190225 IC50 690.0 nM
O=S1(=O)Cc2ccc(/C=C3\c4ccccc4COc4cc(F)ccc43)cc2N1 CHEMBL3775588 Ki 694.0 nM
CCc1ccccc1-n1nc(C(F)(F)F)cc1-c1ccc2c(c1)NC(=O)CO2 CHEMBL1929038 IC50 700.0 nM
CCC(Cc1ccccc1C)NS(=O)(=O)c1c(C)cc(C)cc1C CHEMBL3094469 IC50 700.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc(C(F)(F)F)c1 CHEMBL1215125 IC50 702.0 nM
Cc1onc(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1 CHEMBL3337724 IC50 710.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccccc1Cl)C(F)(F)F CHEMBL237595 IC50 715.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CC[C@@H]3[C@@H]2C2CCCO2)cc1Cl CHEMBL1215410 IC50 720.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccc(C)cc2[nH]1)C(F)(F)F CHEMBL1911652 IC50 720.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cnccc2[nH]1)C(C)(C)C CHEMBL3233279 IC50 720.0 nM
C[C@H]1CN(c2ccc3c(n2)NC(=O)CO3)[C@H](c2ccccc2)CO1 CHEMBL4062371 IC50 727.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc(Cl)cc(C#N)c1)C(F)(F)F CHEMBL235689 IC50 730.0 nM
CN(c1ccccc1)c1ccc(NS(C)(=O)=O)cc1 CHEMBL5176336 Ki 735.0 nM
CC(C)(c1ccccc1)c1ccc(NS(C)(=O)=O)cc1 CHEMBL5201004 Ki 740.0 nM
CC1=CC(C)(C)Nc2ccc3c(c21)C(c1cccc(Cl)c1)Oc1ccccc1-3 CHEMBL320690 IC50 748.0 nM
COc1cc(CNC(=O)[C@@]2(Cc3cccc(Cl)c3)OC(=O)N([C@H](C)c3ccccc3)C2=O)cc(OC)c1 CHEMBL2407637 IC50 750.0 nM
Cc1cc(F)ccc1C1=C(c2ccc3c(c2)NC(=O)CO3)COC1=O CHEMBL2419304 IC50 750.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc(Cl)cc(Cl)c1)C(F)(F)F CHEMBL235480 IC50 760.0 nM
N#Cc1ccc(N2N=C(c3ccc(C(=O)O)cc3)CC2c2cccs2)cc1 CHEMBL1214969 IC50 763.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cn1cnc2ccccc21)C(F)(F)F CHEMBL373498 IC50 775.0 nM
CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cccc2c1OCC2 CHEMBL1254419 IC50 780.0 nM
O=C(O)c1ccc(N2N=C(c3ccc4[nH]c(=O)oc4c3)CC2c2ccc(F)cc2)cc1 CHEMBL1215757 IC50 784.0 nM
CCc1cccc2[nH]c(CC(O)(CC(C)(C)c3cc(F)ccc3OC)C(F)(F)F)cc12 CHEMBL1911645 IC50 790.0 nM
NC(=O)Nc1cc(-c2ccnn2-c2ccccc2Cl)ccn1 CHEMBL3643652 IC50 790.0 nM
CC1CCc2ccccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL4474881 pKi 794.33 nM
Cc1cc(-c2cccc3cc[nH]c23)c(Cl)c2c1NC(C)(C)[C@H](O)[C@H]2C CHEMBL1644759 Ki 800.0 nM
C[C@H](c1ccc(F)cc1)N1C(=O)O[C@](Cc2ccccc2)(c2nc3c(-c4cnoc4)cccc3[nH]2)C1=O CHEMBL3578296 IC50 800.0 nM
CS(=O)(=O)Nc1ccc2c(c1)OC1(CC1)C(=O)N2c1ccc(F)cc1 CHEMBL5183454 Ki 808.0 nM
CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1ccccc1 CHEMBL1253986 IC50 810.0 nM
N#Cc1ccc(N2N=C3c4ccc(C(=O)O)cc4CO[C@@H]3[C@@H]2c2ccc(F)cc2)cc1Cl CHEMBL1215555 IC50 849.0 nM
CC(C)n1cc(-c2ccc(C#N)c(F)c2)c2ccc(NS(C)(=O)=O)cc21 CHEMBL1672547 Ki 849.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCNC(=O)N(C)C4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL384975 Ki 850.0 nM
CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(Cl)cc1Cl CHEMBL233659 IC50 850.0 nM
NC(=O)Nc1cc(-c2nc[nH]c2-c2ccc(F)cc2)ccn1 CHEMBL3643694 IC50 850.0 nM
CC[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@@]3(CC)[C@@H](CC[C@@]34C=CCO4)[C@H]12 CHEMBL3692354 IC50 850.0 nM
COC(=O)C1=C(Cc2ccccc2)NC(C)=C(C#N)C1c1ccccc1Cl CHEMBL1215484 IC50 852.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ncncc2[nH]1)C(F)(F)F CHEMBL3126953 IC50 855.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1ccc(Cl)cc1Cl)C(F)(F)F CHEMBL392568 IC50 875.0 nM
CC(C)(CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F)c1ccc(F)cc1O CHEMBL219207 IC50 880.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc(OC)c1 CHEMBL1215123 IC50 888.0 nM
Cc1cc(-c2cccc3cc[nH]c23)c(Cl)c2c1NC(C)(C)C(O)C2(C)C CHEMBL1644761 Ki 890.0 nM
CCOc1cccc2c1-c1ccc(NS(C)(=O)=O)cc1C(c1ccccc1)O2 CHEMBL66598 IC50 893.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cccc(Cl)c1Cl)C(F)(F)F CHEMBL237807 IC50 900.0 nM
CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)[C@@H](C)O CHEMBL4088261 IC50 900.0 nM
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O CHEMBL4077949 IC50 900.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cccnc2[nH]1)C(F)(F)F CHEMBL1254652 IC50 910.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccc(C(F)(F)F)cc2[nH]1)C(F)(F)F CHEMBL1911653 IC50 910.0 nM
N#Cc1cc(-c2ccc3c(c2)NC(=O)CO3)n(-c2ccc(F)cc2)n1 CHEMBL1929029 IC50 920.0 nM
CCOC(=O)C1=C(c2ccccc2)NC(C)=C(C#N)C1c1ccccc1Cl CHEMBL1215482 IC50 923.0 nM
O=c1[nH]c(N2CCC(c3ccccc3)CC2)c(Cc2ccccc2)c(=O)[nH]1 CHEMBL230675 Ki 930.0 nM
COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc(C)cc(Cl)c1)C(F)(F)F CHEMBL392499 IC50 940.0 nM
COC(=O)C(c1ccc(F)cc1Cl)n1ccc2c(Cl)cccc21 CHEMBL4754975 IC50 940.0 nM
CS(=O)(=O)Nc1cccc2cc[nH]c12 CHEMBL3605925 Ki 952.0 nM
CCc1cc(-c2ccc3c(c2)NC(=O)CO3)n(-c2ccc(F)cc2)n1 CHEMBL1928883 IC50 960.0 nM
CC[C@](C(=O)NC(C)(C)C)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21 CHEMBL4796191 IC50 960.0 nM
C=CCOC(C)C1=CC(C)(C)Nc2ccc(-c3cc(F)ccc3OC)cc21 CHEMBL395506 IC50 970.0 nM
CC1=CC(C)(C)Nc2ccc3c(c21)C(c1ccc(Br)cc1)Oc1ccccc1-3 CHEMBL103232 IC50 977.0 nM
COc1c(O)ccc2c1-c1ccc3c(c1/C(=C/c1sccc1CO)O2)C(C)=CC(C)(C)N3 CHEMBL394369 Ki 980.0 nM
O=C1COc2ccc(COc3ccc(F)cc3F)cc2N1 CHEMBL3774930 Ki 980.0 nM
C[C@H](c1ccccc1)N1C(=O)N[C@](Cc2ccccc2)(C(=O)N2CCc3ccccc3C2)C1=O CHEMBL2407660 IC50 990.0 nM
Cc1nn(Cc2ccccn2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2 CHEMBL3337735 IC50 990.0 nM