O=C1COc2cc(C(=O)N(Cc3ccc(C(=O)Nc4ccncn4)cc3)C3CC3)ccc2N1 CHEMBL5200945 Kd 10.0 nM
CNC(=O)[C@@]1(N)CCCN(c2cnc(-c3cccc(F)c3)cc2Cn2cnc3c(N)ncnc32)C1 CHEMBL5438639 IC50 12.0 nM
N=C(N)NCCC[C@H](N)C(=O)NCCCCCCNC(=O)c1ccc(NC(=O)c2ccc(CN(C(=O)c3ccc4c(c3)OCC(=O)N4)C3CC3)cc2)cc1 CHEMBL5440549 Kd 14.0 nM
Nc1ncnc2c1ncn2Cc1cc(-c2ccc(F)c(F)c2)ncc1N1CCC[C@](N)(c2ccccn2)C1 CHEMBL5422710 IC50 18.0 nM
CC[C@H](C)C(=O)[C@@]1(N)CCCN(c2cnc(-c3ccc(F)c(F)c3)cc2Cn2cnc3c(N)ncnc32)C1 CHEMBL5437594 IC50 34.0 nM
O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(NC(=O)c2ccc(CN(C(=O)c3ccc4c(c3)OCC(=O)N4)C3CC3)cc2)cc1 CHEMBL5416709 Kd 46.0 nM
CCn1nc(/C=C/c2ccccc2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL599924 AC50 87.9 nM
CN1CCN(C2=C(Cl)C(=O)c3ccccc3C2=O)CC1 CHEMBL1163377 AC50 108.0 nM
Cc1cc(CN2CCC(N)CC2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 CHEMBL5186268 IC50 110.0 nM
O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21 CHEMBL337173 IC50 110.0 nM
CC1NC(=O)NC1CCCCCC(=O)Nc1ccc(F)cc1 CHEMBL1311154 AC50 113.0 nM
Cc1ccccc1NC1=C/C(=N\S(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc2C1=O CHEMBL1999630 AC50 117.0 nM
NC1=C(Cl)C(=O)c2ccc(S(N)(=O)=O)cc2C1=O CHEMBL1734083 AC50 144.0 nM
O=c1ccc2c(-c3ccccc3S(=O)(=O)O)c3ccc(O)c(O)c3oc-2c1O CHEMBL210208 AC50 146.0 nM
NC1=C(Br)C(=O)c2ncccc2C1=O CHEMBL1735482 AC50 164.0 nM
O=C1C(Cl)=C(NCCC2(O)CCN(C(=O)C3CC3(F)F)CC2)C(=O)c2ncccc21 CHEMBL5406268 IC50 200.0 nM
O=C1C(Cl)=C(NC2CCc3ccccc32)C(=O)c2ncccc21 CHEMBL131199 IC50 210.0 nM
CC#CC(=O)NC12CC(NC3=C(Cl)C(=O)c4ncccc4C3=O)(C1)C2 CHEMBL5422549 IC50 230.0 nM
C[C@@](O)(C(=O)N1CCC(O)(CCNC2=C(Cl)C(=O)c3cccnc3C2=O)CC1)C(F)(F)F CHEMBL5418169 IC50 240.0 nM
CC(C)(O)[C@H](F)CNC1=C(Cl)C(=O)c2ccc(Cl)nc2C1=O CHEMBL5412847 IC50 250.0 nM
CC#CC(=O)NC12CC(NC3=C(Cl)C(=O)c4cccnc4C3=O)(C1)C2 CHEMBL5415704 IC50 250.0 nM
Cc1ccc(S(=O)(=O)/N=C2\C=C(Nc3cccc(C(=O)O)c3)C(=O)c3ccccc32)c(C)c1 CHEMBL1969046 AC50 255.0 nM
CCOC(=O)c1c2c(n(Cc3ccccc3)c1C)C(=O)C(=O)c1ccccc1-2 CHEMBL1733422 AC50 263.0 nM
CCc1ccc(S(=O)(=O)/N=C2\C=C(Nc3cccc(C(=O)O)c3)C(=O)c3ccccc32)cc1 CHEMBL3190880 AC50 263.0 nM
Nc1ccc2c(c1)C(=O)C(=O)c1ccccc1-2 CHEMBL417727 AC50 273.0 nM
COc1cc(OC)c(-c2c3cc(O)c(=O)cc-3oc3cc(O)c(O)cc23)cc1OC CHEMBL1571034 AC50 282.0 nM
CC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc21 CHEMBL284328 AC50 293.0 nM
CC(C)(O)[C@H](F)CNC1=C(Cl)C(=O)c2cccnc2C1=O CHEMBL5433538 IC50 300.0 nM
CC(F)(F)C(=O)NC12CC(NC3=C(Cl)C(=O)c4cccnc4C3=O)(C1)C2 CHEMBL5402620 IC50 300.0 nM
CC#CC(=O)NC1CN(C2=C(Cl)C(=O)c3cccnc3C2=O)C1 CHEMBL5401066 IC50 310.0 nM
CC(F)(F)C(=O)NC12CC(NC3=C(Cl)C(=O)c4ncccc4C3=O)(C1)C2 CHEMBL5418912 IC50 330.0 nM
CC(F)(F)C(=O)N1CCC2(CC1)CN(C1=C(Cl)C(=O)c3cccnc3C1=O)C2 CHEMBL5419286 IC50 330.0 nM
CC1NC(=O)NC1CCCCCC(=O)Nc1ccc(F)c(Cl)c1 CHEMBL1399113 AC50 343.0 nM
N#Cc1ccc(C(=O)N(Cc2cccs2)C2CC2)cc1 CHEMBL4758943 Kd 349.0 nM
O=C1COc2cc(C(=O)N(Cc3cccs3)C3CC3)ccc2N1 CHEMBL5401805 Kd 349.0 nM
NCCCCCCNC(=O)c1ccc(NC(=O)c2ccc(CN(C(=O)c3ccc4c(c3)OCC(=O)N4)C3CC3)cc2)cc1 CHEMBL5422577 EC50 350.0 nM
Cc1ccc(NC(=O)CCCCCC2NC(=O)NC2C)cc1 CHEMBL1343539 AC50 358.0 nM
CC(C)(O)[C@H](F)CNC1=C(Cl)C(=O)c2ccc(N3CCCC3)nc2C1=O CHEMBL5419919 IC50 360.0 nM
CC(F)(F)C(=O)NC1CN(C2=C(Cl)C(=O)c3ncccc3C2=O)C1 CHEMBL5402868 IC50 360.0 nM
CC(F)(F)C(=O)NCCC1CN(C2=C(Cl)C(=O)c3cccnc3C2=O)C1 CHEMBL5436306 IC50 380.0 nM
CC(F)(F)C(=O)NCCC1CN(C2=C(Cl)C(=O)c3ncccc3C2=O)C1 CHEMBL5402955 IC50 380.0 nM
COC(=O)c1cc(C)nc2c1C(=O)C(=O)C=C2N1CCOCC1 CHEMBL1432707 AC50 407.0 nM
O=C1Nc2ccccc2/C1=N/N=C/c1ccc(O)c(O)c1 CHEMBL607979 AC50 407.0 nM
O=C1C(Cl)=C(NC23CC(NC(=O)C4CC4(F)F)(C2)C3)C(=O)c2ncccc21 CHEMBL5435504 IC50 410.0 nM
COc1cc(Br)c(C(=O)c2nccc3cc(OC)c(OC)cc23)cc1OC CHEMBL1598762 AC50 416.0 nM
C[C@@](O)(C(=O)NC12CC(NC3=C(Cl)C(=O)c4cccnc4C3=O)(C1)C2)C(F)(F)F CHEMBL5440868 IC50 420.0 nM
Cc1ccc(S(=O)(=O)/N=C2\C=C(Nc3cccc(C(=O)O)c3)C(=O)c3ccccc32)cc1 CHEMBL1982305 AC50 422.0 nM
Cc1cc(CNC2CC2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 CHEMBL5204960 IC50 430.0 nM
O=C1C(NC2CCc3ccccc32)=C(Cl)C(=O)c2ncccc21 CHEMBL5408020 IC50 450.0 nM
O=C1C(Cl)=C(NCCc2c[nH]c3ccccc23)C(=O)c2ncccc21 CHEMBL340219 IC50 450.0 nM
COc1cc(NC(C)CCCN)c2ncccc2c1Oc1ccccc1 CHEMBL1327934 AC50 466.0 nM
CC(F)(F)C(=O)NC1CN(C2=C(Cl)C(=O)c3cccnc3C2=O)C1 CHEMBL5422301 IC50 470.0 nM
O=C1C(NCCN2CCOCC2)=C(Cl)C(=O)c2ncccc21 CHEMBL337520 IC50 490.0 nM
CC#CC(=O)NCCC1CCN(C2=C(Cl)C(=O)c3ncccc3C2=O)CC1 CHEMBL5401031 IC50 490.0 nM
Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 CHEMBL5172030 IC50 520.0 nM
Cc1cc(CN2CCC(O)C2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 CHEMBL5181192 IC50 520.0 nM
Cc1ccc2c(c1C)-c1c(ccc(C)c1C)C(=O)C2=O CHEMBL1698715 AC50 531.0 nM
O=c1c(O)cccc2cc(O)c(O)c(O)c12 CHEMBL66953 AC50 532.0 nM
NC1=CC(=O)C(=O)c2cccnc21 CHEMBL156174 AC50 546.0 nM
CC(=O)N(/N=C1\Sc2ccccc2C1=O)c1ccccc1C CHEMBL2000196 AC50 548.0 nM
COC(=O)c1ccccc1NC1=C/C(=N\S(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc2C1=O CHEMBL3197637 AC50 557.0 nM
Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)cc1 CHEMBL5197903 IC50 570.0 nM
CC#CC(=O)NC1CN(C2=C(Cl)C(=O)c3ncccc3C2=O)C1 CHEMBL5435611 IC50 590.0 nM
O=C1C(Cl)=C(Oc2ccccc2)C(=O)c2ccccc21 CHEMBL1699845 AC50 598.0 nM
COC1=C(N)C(=O)c2nc(C)ccc2C1=O CHEMBL1702473 AC50 610.0 nM
Cc1cc(CNCCN)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 CHEMBL5170310 IC50 620.0 nM
Oc1ccc(/C=N/N=C(c2ccccc2)c2ccccc2)c(O)c1O CHEMBL1966224 AC50 635.0 nM
Cc1cc(CNC(C)(C)C)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 CHEMBL5170326 IC50 640.0 nM
O=[N+]([O-])c1ccc(-[n+]2nc(-c3ccccc3)nn2-c2ccccc2)cc1 CHEMBL1542926 AC50 654.0 nM
COc1cc(-c2nnc(SCc3cc(=O)oc4cc(O)c(O)cc34)o2)cc(OC)c1OC CHEMBL1381627 AC50 665.0 nM
CCNCc1cc(C)c(-c2ncn(C)c2-c2ccc(C#N)c3ccccc23)c(C)c1 CHEMBL5195926 IC50 700.0 nM
O=C(O)c1cccc(-n2cccc2/C=C2/NC(=O)N(c3ccc(Cl)cc3)C2=O)c1 CHEMBL1424694 AC50 720.0 nM
O=C(CSc1nc2ccccc2o1)N/N=C/c1ccc(O)c(O)c1 CHEMBL1982107 AC50 742.0 nM
CN(C)c1ccc2cc(S(=O)(=O)O)cc(O)c2c1 CHEMBL1737002 AC50 747.0 nM
CC(N=C1C=C(O)c2cccnc2C1=O)C(O)c1ccccc1 CHEMBL1698802 AC50 754.0 nM
CC#CC(=O)N1CCC2(CC1)CN(C1=C(Cl)C(=O)c3cccnc3C1=O)C2 CHEMBL5424751 IC50 760.0 nM
CC1COCC(C)N1C1=C(Cl)C(=O)c2ccccc2C1=O CHEMBL1734152 AC50 873.0 nM
CC(=O)N1CCC(N2C[C@H]3C[C@@H](C2)c2ccc(-c4ccccc4CN4CCOCC4)c(=O)n2C3)CC1 CHEMBL4876215 IC50 890.0 nM
CC(=O)N1CCC(N2C[C@@H]3C[C@@H](C2)c2ccc(-c4ccccc4CN4CCOCC4)c(=O)n2C3)CC1 CHEMBL5406103 IC50 890.0 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCC(=O)NCCCOc4ccc(NC(=O)c5ccc(CN(C(=O)c6ccc7c(c6)OCC(=O)N7)C6CC6)cc5)nc4)c3C2=O)C1=O CHEMBL5193618 Kd 900.0 nM
CC(C)(O)[C@H](F)CNC1=C(Cl)C(=O)c2ccc(N3CCC(F)(F)C3)nc2C1=O CHEMBL5397372 IC50 930.0 nM
O=C1C(=O)c2cccnc2-c2ncccc21 CHEMBL235504 AC50 981.0 nM
C[C@@](O)(C(=O)N1CCC(O)(CCNC2=C(Cl)C(=O)c3ncccc3C2=O)CC1)C(F)(F)F CHEMBL5407373 IC50 990.0 nM