C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(c3n2)C(=O)N1 CHEMBL4297627 IC50 0.07 nM
Cc1cc(-c2cnc3ccc(N[C@@H](C)c4ccc(F)cc4F)nn23)[nH]n1 CHEMBL4562879 IC50 0.1 nM
CCn1cc(-c2cnn3ccc(N[C@H](C)c4cc(F)ccc4F)nc23)cn1 CHEMBL5170464 IC50 0.1 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C(F)F)c3)c2n1)c1cc(F)ccc1F CHEMBL5170096 IC50 0.1 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C4CCC4)c3)c2n1)c1cc(F)ccc1F CHEMBL5189971 IC50 0.1 nM
C[C@H]1CNC(=O)c2cnn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1 CHEMBL4298138 IC50 0.11 nM
Cn1ccc(-c2cc(C(=O)Nc3c4ncc(C(C)(C)O)cc4nn3-c3ccccc3)c(F)cc2C(F)(F)F)n1 CHEMBL4518176 IC50 0.16 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCO)c2n1 CHEMBL3676026 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)nc1 CHEMBL3673477 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)cc1 CHEMBL3673478 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C2CC2)nc1 CHEMBL3673479 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(OC(F)(F)F)cc1 CHEMBL3678283 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(SC(F)(F)F)cc1 CHEMBL3678284 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(C)C)nc1 CHEMBL3678285 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(CC(F)(F)F)cc1 CHEMBL3678286 IC50 0.2 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1csc(C(F)(F)F)n1 CHEMBL3678287 IC50 0.2 nM
CC(C)N1Cc2cc(c(F)cc2F)OCCCNC(=O)c2cnn3ccc1nc23 CHEMBL4449648 IC50 0.2 nM
CC(C)N1Cc2cc(cc(F)c2Cl)O[C@@H](C)CNC(=O)c2cnn3cc1cnc23 CHEMBL4554856 IC50 0.2 nM
CS(=O)(=O)c1ccc(F)cc1CNc1ccc2[nH]nc(-c3cccnc3)c2c1 CHEMBL4462919 IC50 0.2 nM
Cn1cc(-c2n[nH]c3ccc(NCc4cc(F)ccc4S(C)(=O)=O)cc23)cn1 CHEMBL4555442 IC50 0.2 nM
Cn1cc(-c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4OCC(F)F)nc23)cn1 CHEMBL5092943 IC50 0.2 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(CCO)c3)c2n1)c1cc(F)ccc1OCC(F)F CHEMBL5088000 IC50 0.2 nM
C[C@@H](Nc1ccn2ncc(-c3cn[nH]c3)c2n1)c1cc(F)ccc1F CHEMBL5175608 IC50 0.2 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(CCO)c3)c2n1)c1cc(F)ccc1F CHEMBL5188045 IC50 0.2 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C4CC4)c3)c2n1)c1cc(F)ccc1F CHEMBL5173256 IC50 0.2 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C4CCOC4)c3)c2n1)c1cc(F)ccc1F CHEMBL5198983 IC50 0.2 nM
Fc1ccc(F)c([C@H]2CCCN2c2ccn3ncc(-c4cn[nH]c4)c3n2)c1 CHEMBL5200318 IC50 0.2 nM
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)n[nH]1 CHEMBL457614 Kd 0.204 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL1983268 IC50 0.22 nM
CC(O)c1cnc2c(NC(=O)c3cc(-c4ccn(C)n4)c(C(F)(F)F)cc3F)n(-c3ccccc3)nc2c1 CHEMBL4562203 IC50 0.25 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)ccc43)cc2OC)cc1 CHEMBL3673436 IC50 0.3 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)cnc43)cc2OC)cc1 CHEMBL3673452 IC50 0.3 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)C(F)(F)F)cc1 CHEMBL3673489 IC50 0.3 nM
COc1cc([C@H](C)n2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)cc1 CHEMBL3678297 IC50 0.3 nM
CS(=O)(=O)c1ccc(F)cc1CNc1ccc2[nH]nc(-c3ccc(N4CCNCC4)nc3)c2c1 CHEMBL4528647 IC50 0.3 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C)c3)c2n1)c1cc(F)ccc1OCC(F)F CHEMBL5078405 IC50 0.3 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(S(C)(=O)=O)c3)c2n1)c1cc(F)ccc1F CHEMBL5196651 IC50 0.3 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(CCC#N)c3)c2n1)c1cc(F)ccc1F CHEMBL5169970 IC50 0.3 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C4CCCC4)c3)c2n1)c1cc(F)ccc1F CHEMBL5193919 IC50 0.3 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C4CCOCC4)c3)c2n1)c1cc(F)ccc1F CHEMBL5195375 IC50 0.3 nM
Cn1ccc(-c2cc(C(=O)Nc3c(-c4ccccc4)nc4ccc(C(C)(C)O)cn34)ccc2C(F)(F)F)n1 CHEMBL4437772 IC50 0.34 nM
O=C(NCCc1cnc[nH]1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671153 IC50 0.4 nM
COc1cc(C(C)n2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)nc1 CHEMBL3678300 IC50 0.4 nM
CS(=O)(=O)c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cc(F)cnc3N)cc2)nc1 CHEMBL3981141 IC50 0.4 nM
O=C(Nc1ccc(N2CCOCC2)cc1N1CCOCC1)c1cnn(-c2ccccc2)n1 CHEMBL4740028 Ki 0.4 nM
Cn1cc(-c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)cn1 CHEMBL5075273 IC50 0.4 nM
COCCn1cc(-c2cnn3ccc(N[C@H](C)c4cc(F)ccc4F)nc23)cn1 CHEMBL5170412 IC50 0.4 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1 CHEMBL3889654 IC50 0.4 nM
C[C@H]1CNC(=O)c2ncn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1 CHEMBL5400169 IC50 0.4 nM
O=C(N[C@H]1CC[C@H](O)CC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671135 IC50 0.45 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.5 nM
O=C(NC1CC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671141 IC50 0.5 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccc(P(C)(C)=O)nc5)cnc43)cc2OC)cc1 CHEMBL3673453 IC50 0.5 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1csc(C)n1 CHEMBL3673480 IC50 0.5 nM
CS(=O)(=O)c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cc(Cl)cnc3N)cc2)nc1 CHEMBL3892052 IC50 0.5 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(C4COC4)c3)c2n1)c1cc(F)ccc1F CHEMBL5205989 IC50 0.5 nM
COc1ccc(F)cc1CNc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2 CHEMBL5402022 IC50 0.5 nM
O=C(NC1CCC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671142 IC50 0.55 nM
O=C(NOCC1CC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675942 IC50 0.57 nM
COCCN1C[C@@H](NC(=O)Nc2c(C)c(-c3cnn(C)c3)nn2-c2ccccc2)[C@@H]2c3ccccc3CC[C@H]21 CHEMBL4541382 IC50 0.59 nM
Cc1ccc(Sc2cnc(Nc3cccc(Br)n3)s2)cc1C(=O)N1CCN(C(=O)CN)CC1 CHEMBL254895 IC50 0.6 nM
O=C(N[C@H]1CC2CCC1C2)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671143 IC50 0.6 nM
O=C(NC1CCOCC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671148 IC50 0.6 nM
O=C(NC1CC1)c1cnn2ccc(N3CCCC3c3cc(F)ccc3CO)nc12 CHEMBL3675926 IC50 0.6 nM
CONC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675941 IC50 0.6 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)cnc43)cc2OC)cn1 CHEMBL3673476 IC50 0.6 nM
C[C@H]1CCc2ncc(F)cc2[C@@H]2CCCN2c2ccn3ncc(c3n2)C(=O)N1 CHEMBL4761560 IC50 0.6 nM
COCC[C@@H]1C[C@@H](NC(=O)Nc2c(C)c(-c3cnn(C)c3)nn2-c2ccccc2)[C@@H]2c3ccccc3C(F)(F)CN12 CHEMBL4471633 IC50 0.64 nM
Cc1c(OCC2CCN(C)CC2)nn(-c2ccccc2)c1NC(=O)N[C@H]1CN(CC(F)(F)F)[C@@H]2COc3ccccc3[C@H]12 CHEMBL4528960 IC50 0.64 nM
Cn1ccc(-c2cc(C(=O)Nc3c4ncccc4nn3-c3ccccc3)c(F)cc2C(F)(F)F)n1 CHEMBL4574462 IC50 0.66 nM
Cc1cc(C(=O)NC(C)(C)C)cc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)n1 CHEMBL4457566 IC50 0.68 nM
Nc1ncc2c(C(=O)c3cncc(NC(=O)Cc4ccc(Cl)cn4)c3)cn(C34CC(C3)C4)c2n1 CHEMBL3671472 IC50 0.681 nM
CC(C)(C)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671129 IC50 0.7 nM
O=C(Nc1ccccn1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671130 IC50 0.7 nM
N#CCNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3675917 IC50 0.7 nM
Cc1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5cccnc5)cn4)cc3)c2n1 CHEMBL3974941 IC50 0.7 nM
Cn1cnc(-c2cnc(O[C@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C[C@H]3F)c(C(N)=O)c2)c1 CHEMBL4210892 Kd 0.7 nM
O=C1NC2(CC2)COc2ncc(F)cc2[C@H]2CCCCN2c2ccn3ncc1c3n2 CHEMBL5093999 IC50 0.7 nM
CC(C)(C)NC(=O)c1ccnc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)c1 CHEMBL5172448 IC50 0.7 nM
CCc1cc(C(=O)NC(C)(C)C)cc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)n1 CHEMBL5174525 IC50 0.7 nM
Fc1ccc(OCC(F)(F)F)c([C@H]2CCCN2c2ccn3ncc(-c4cn[nH]c4)c3n2)c1 CHEMBL5195177 IC50 0.7 nM
CC(C)(CF)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675918 IC50 0.8 nM
CS(=O)(=O)c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cc(C(F)(F)F)cnc3N)cc2)nc1 CHEMBL3966864 IC50 0.8 nM
Cn1cc(-c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)c(C(F)(F)F)n1 CHEMBL5171308 IC50 0.8 nM
FCCOc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(-c3cn[nH]c3)c2n1 CHEMBL5196625 IC50 0.8 nM
Fc1ccc(OCC(F)F)c([C@H]2CCCN2c2ccn3ncc(-c4cn[nH]c4)c3n2)c1 CHEMBL5203484 IC50 0.8 nM
OC1CCN(c2cc(-c3cccc(-c4cnc5ccc(N6CCC[C@@H]6c6cccc(F)c6)nn45)n3)ccn2)CC1 CHEMBL4646064 Kd 0.81 nM
Nc1ncc2c(C(=O)c3cncc(NC(=O)Cn4ccc(C(F)(F)F)n4)c3)cn(C34CC(C3)C4)c2n1 CHEMBL3671469 IC50 0.825 nM
O=C(Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1)C1CC1 CHEMBL3545365 IC50 0.85 nM
C[C@@H]1COc2cn3ncc4c3nc2N1Cc1ccc(F)cc1O[C@@H](C)CNC4=O CHEMBL5178203 IC50 0.86 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCCOCCC(=O)N4CCN(c5cccc(-c6cnc7ccc(N8CCC[C@@H]8c8cccc(F)c8)nn67)n5)CC4)c3C2=O)C1=O CHEMBL4790500 Kd 0.88 nM
CC(C)(O)c1ccc2nc(-c3ccccc3)c(NC(=O)c3cc(-c4ncccn4)c(C(F)(F)F)cc3F)n2c1 CHEMBL4459162 IC50 0.89 nM
O=C(NC1(CO)CC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671144 IC50 0.9 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCC(O)CC3)c2n1 CHEMBL3904952 IC50 0.9 nM
O=C(N[C@H]1CC[C@H](O)C1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3676038 IC50 0.9 nM
COc1cc(Cn2cnc3cc(-c4cnn(C5CCNCC5)c4)cnc32)ccc1OCc1ccc(C)nc1 CHEMBL3673463 IC50 0.9 nM
CS(=O)(=O)Nc1ccccc1CNc1ccc2[nH]nc(-c3ccc(NC4CCNCC4)nc3)c2c1 CHEMBL4549659 IC50 0.9 nM
O=C(Nc1cnn2ccc(N3CCC[C@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1 CHEMBL3892335 IC50 0.9 nM
Fc1ccc(F)c([C@H]2CCCN2c2ccn3ncc(-c4cnn(C(F)F)c4)c3n2)c1 CHEMBL5170146 IC50 0.9 nM
CC(C)(C)c1cc(NC(=O)Cn2cc(-c3ccc(-n4ccnc4)nc3)nn2)n(-c2cccnc2)n1 CHEMBL3298268 Kd 0.94 nM
O=C(NCCN1CCOCC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671132 IC50 0.95 nM
Cc1ccc(CNC(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)o1 CHEMBL3671133 IC50 0.95 nM
COCCOc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 CHEMBL3675965 IC50 0.95 nM
Cc1ccc(Sc2cnc(Nc3cccc(Br)n3)s2)cc1C(=O)N1CCN(C(=O)[C@@H](C)N)CC1 CHEMBL251796 IC50 1.0 nM
Cc1ccc(Sc2cnc(Nc3cccc(Br)n3)s2)cc1C(=O)N1CCN(C(=O)[C@H](C)N)CC1 CHEMBL251795 IC50 1.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(Nc4cccc(Br)n4)s3)ccc2C)CC1 CHEMBL254050 IC50 1.0 nM
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc(NC[C@@H](O)CO)c2Cl)n[nH]1 CHEMBL513953 EC50 1.0 nM
C[C@H](Nc1ncc(Cl)c(Nc2cc(C3CC3)[nH]n2)n1)c1ccc(F)cn1 CHEMBL457608 EC50 1.0 nM
O=C(O)CN1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1 CHEMBL3582441 IC50 1.0 nM
O=C(NCC(O)CO)c1cnn2ccc(N3CCCC3c3cc(F)ccc3CO)nc12 CHEMBL3675932 IC50 1.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-c5cnn(C6CCNCC6)c5)cnc43)cc2OC)cn1 CHEMBL3673462 IC50 1.0 nM
COc1cc(C(C)n2c(N)nc3cc(C#CCCO)cnc32)ccc1OCc1ccc(C(F)(F)F)nc1 CHEMBL3678301 IC50 1.0 nM
CCCNc1ncc(-c2ccc(Oc3ncc(NC(=O)Nc4cc(C(F)(F)F)ccc4S(C)(=O)=O)cn3)cc2)s1 CHEMBL3968770 IC50 1.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3cccn3)cn2)cc1 CHEMBL3915638 IC50 1.0 nM
Cc1cn(-c2ccc(C(F)(F)F)cc2NC(=O)Nc2cnc(Oc3ccc(-c4cc(Cl)cnc4N)cc3)nc2)nn1 CHEMBL3977304 IC50 1.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3Cl)cn2)cc1 CHEMBL3968810 IC50 1.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3ccnn3)cn2)cc1 CHEMBL3950761 IC50 1.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3-c3cccnc3)cn2)cc1 CHEMBL3899159 IC50 1.0 nM
Nc1ncc(F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3ccnn3)cn2)cc1 CHEMBL3984502 IC50 1.0 nM
Nc1ncc(F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-c3cccnc3)cn2)cc1 CHEMBL3909331 IC50 1.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(C(F)(F)F)cc3-n3cccn3)cn2)cc1 CHEMBL3976441 IC50 1.0 nM
Nc1ncc(C(F)(F)F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3cc(Cl)cn3)cn2)cc1 CHEMBL3952347 IC50 1.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnn4ccc(N5CCC5)nc34)cc2)nc1)Nc1cc(C(F)(F)F)ccc1-c1cccnc1 CHEMBL3904509 IC50 1.0 nM
Cn1nccc1-c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cnn4ccc(N5CCC5)nc34)cc2)nc1 CHEMBL3938428 IC50 1.0 nM
COc1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5cccnc5)cn4)cc3)c2n1 CHEMBL3957079 IC50 1.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnn4cccnc34)cc2)nc1)Nc1cc(C(F)(F)F)ccc1-c1cccnc1 CHEMBL3947206 IC50 1.0 nM
CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5cccnc5)cn4)cc3)c2n1 CHEMBL3915877 IC50 1.0 nM
CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5ccnn5C)cn4)cc3)c2n1 CHEMBL3952568 IC50 1.0 nM
COc1ccc2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5cccnc5)cn4)cc3)n2n1 CHEMBL3919320 IC50 1.0 nM
COc1ccc2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-n5cccn5)cn4)cc3)n2n1 CHEMBL3928224 IC50 1.0 nM
CCOc1ccc2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5cccnc5)cn4)cc3)n2n1 CHEMBL3950525 IC50 1.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnc4ccccn34)cc2)nc1)Nc1cc(C(F)(F)F)ccc1-n1cccn1 CHEMBL3955841 IC50 1.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnc4cnccn34)cc2)nc1)Nc1cc(C(F)(F)F)ccc1-c1cccnc1 CHEMBL3910954 IC50 1.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnn4ccccc34)cc2)nc1)Nc1cc(C(F)(F)F)ccc1-c1cccnc1 CHEMBL3976747 IC50 1.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnc4[nH]ncc4c3)cc2)nc1)Nc1cc(C(F)(F)F)ccc1-c1cccnc1 CHEMBL3895805 IC50 1.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(SCc3ccc(F)cc3)n2)n[nH]1 CHEMBL4212119 pKd 1.0 nM
Cn1cnc(-c2cnc(N)c(O[C@H]3CN(C(=O)Cc4ccc(OC(F)(F)F)cc4)CC3(F)F)c2)c1 CHEMBL4216500 IC50 1.0 nM
Cn1ccc(-c2cc(C(=O)Nc3c(-c4ccccc4)nc4ccc(CO)cn34)ccc2C(F)(F)F)n1 CHEMBL4438294 IC50 1.0 nM
O=C1CCC(N2C(=O)c3cccc(NCCOCCC(=O)N4CCN(c5cccc(-c6cnc7ccc(N8CCC[C@@H]8c8cccc(F)c8)nn67)n5)CC4)c3C2=O)C(=O)N1 CHEMBL4798635 Kd 1.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5088153 Ki 1.0 nM
O=C1Nc2ccc(NCc3cc(F)ccc3F)cc2/C1=C/c1cnc[nH]1 CHEMBL5431992 IC50 1.0 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL3915172 IC50 1.02 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4cccc(F)n4)c(Cl)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL4539407 IC50 1.02 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(F)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL3949290 IC50 1.04 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4cccc(F)n4)c(F)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL4444487 IC50 1.04 nM
CNC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671138 IC50 1.05 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cnc(N)nc21 CHEMBL3666259 IC50 1.09 nM
CC(C)(CO)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671136 IC50 1.1 nM
Cn1cncc1CCNC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671151 IC50 1.1 nM
O=C(NC1CCC(O)CC1)c1cnn2ccc(N3CCCC3c3cc(F)ccc3CO)nc12 CHEMBL3675912 IC50 1.1 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCO)c2n1 CHEMBL3676019 IC50 1.1 nM
O=C(NCCO)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3676034 IC50 1.1 nM
COCCN1C[C@@H](NC(=O)Nc2c(C)c(-c3ccnc(C)n3)nn2-c2ccccc2)[C@H](c2cccc(F)c2)C1 CHEMBL4437728 IC50 1.1 nM
CO[C@H]1CC[C@H](NC(=O)c2cnn3ccc(N(C)Cc4cccc(F)c4)nc23)CC1 CHEMBL5266269 IC50 1.1 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(CCN(C)C)C3=O CHEMBL3671311 IC50 1.141 nM
CC(C)(CF)NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)cnc3CO)nc12 CHEMBL3675956 IC50 1.15 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(Cl)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL3963962 IC50 1.17 nM
CC1(O)CCC(NC(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)CC1 CHEMBL3916880 IC50 1.18 nM
COC(=O)[C@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL94678 IC50 1.2 nM
O=C(N[C@H]1CC[C@H](O)CC1)c1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12 CHEMBL3675913 IC50 1.2 nM
CC(C)(CO)CNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3676037 IC50 1.2 nM
CCCc1cc(C(=O)NC(C)(C)C)cc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)n1 CHEMBL5171942 IC50 1.2 nM
O=C(NC[C@@H](O)CO)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671154 IC50 1.3 nM
O=C(NC[C@H](O)CO)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671157 IC50 1.3 nM
CC(C)(C#N)NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3675916 IC50 1.3 nM
O=C(NC1CC1)c1cnn2ccc(N3CCCC3c3cc(F)cnc3CO)nc12 CHEMBL3675954 IC50 1.3 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 CHEMBL3676025 IC50 1.3 nM
COCCN1C[C@@H](NC(=O)Nc2c(C)c(C(C)(C)C)nn2-c2ccccc2)[C@H](c2ccc(F)c(F)c2)C1 CHEMBL4443081 IC50 1.3 nM
CC1(C)c2cc(OCCN3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(C(=O)NC4CC4)ccn3)ccc21 CHEMBL5183149 IC50 1.3 nM
CN(Cc1cccc(F)c1)c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)CC3)c2n1 CHEMBL5282675 IC50 1.3 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151321 IC50 1.4 nM
NS(=O)(=O)N1CCC(NC(=O)c2cnn3ccc(N4CCCC4c4cc(F)ccc4F)nc23)CC1 CHEMBL3675923 IC50 1.4 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCCO)c2n1 CHEMBL3676022 IC50 1.4 nM
CS(=O)(=O)c1ccccc1CNc1ccc2[nH]nc(-c3ccc(N4CCNCC4)nc3)c2c1 CHEMBL4457481 IC50 1.4 nM
CC(C)N(C(=O)Nc1cnn2ccc(N(C)[C@H](C)c3cc(F)ccc3F)nc12)C(C)C CHEMBL4743163 IC50 1.4 nM
CC1(C)c2cc(N3CCNC(=O)C3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5189763 IC50 1.4 nM
C[C@@H]1COc2cn3ncc4c3nc2N1Cc1ccc(F)cc1OCC(C)(C)NC4=O CHEMBL5205937 IC50 1.4 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 IC50 1.405 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C3CC3)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5423601 IC50 1.42 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccc(F)cn4)c(Cl)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL3894182 IC50 1.43 nM
Cc1cn2cc(CNc3ncnc4ccc(N5CCC[C@@H]5c5cc(F)ccc5F)nc34)nc2s1 CHEMBL3298265 IC50 1.5 nM
O=C(NC1CCC(C(=O)O)CC1)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3675911 IC50 1.5 nM
CS(=O)(=O)N1CCC(NC(=O)c2cnn3ccc(N4CCCC4c4cc(F)ccc4F)nc23)CC1 CHEMBL3675922 IC50 1.5 nM
NS(=O)(=O)CCNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3675925 IC50 1.5 nM
O=C(NC(CO)CO)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3676042 IC50 1.5 nM
Fc1cc(F)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4785469 IC50 1.5 nM
CO[C@H]1CC[C@H](NC(=O)c2cnn3ccc(NCc4cccc(F)c4)nc23)CC1 CHEMBL5275171 IC50 1.5 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Nc3cc(C4CC4)nn3-c3cnn(C)c3)c2)c2cncnc21 CHEMBL3671460 IC50 1.51 nM
COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C4CC4)n3)c2)c2cncnc21 CHEMBL3671414 IC50 1.51 nM
Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3968335 IC50 1.51 nM
Cn1ccc(NC(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)n1 CHEMBL3671134 IC50 1.55 nM
COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cncnc21 CHEMBL3671412 IC50 1.57 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(NS(C)(=O)=O)cc3)c2)c2cnc(N)nc21 CHEMBL3671437 IC50 1.57 nM
CN1CCN(c2cc(Nc3cc(C4CCCC4)[nH]n3)nc(Sc3ccccc3)n2)CC1 CHEMBL4204878 pKd 1.585 nM
NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3C(F)(F)F)nc12 CHEMBL3675940 IC50 1.6 nM
CS(=O)(=O)Nc1ccccc1CNc1ccc2[nH]nc(-c3ccc(N4CCNCC4)nc3)c2c1 CHEMBL4457858 IC50 1.6 nM
C[C@@H](Nc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1)c1cc(F)cc(F)c1 CHEMBL4792981 IC50 1.6 nM
O=C(N[C@H]1CC[C@H](O)CC1)c1cnn2ccc(NCc3cccc(F)c3)nc12 CHEMBL5288589 IC50 1.6 nM
CN1CCN(c2ccc(NCc3cn(-c4cccc(CNc5cc(F)cc(F)c5)c4)nn3)cc2C(=O)N2CCOCC2)CC1 CHEMBL5406821 IC50 1.6 nM
O=C(NC1CC1)c1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12 CHEMBL3675915 IC50 1.65 nM
Nc1cc(NS(=O)(=O)c2cccc(C(F)(F)F)c2)cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)c1 CHEMBL2152288 IC50 1.67 nM
CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326006 IC50 1.67 nM
C[C@H](NC(=O)c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12)C(F)(F)F CHEMBL3676004 IC50 1.7 nM
O=C(NC1CC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)cc(OCC(O)CO)c3)nc12 CHEMBL3676074 IC50 1.7 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)c1ccccn1 CHEMBL4115470 IC50 1.7 nM
Cc1cccnc1C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4114873 IC50 1.7 nM
COCCN1C[C@@H](NC(=O)Nc2c(C)c(-c3cnn(C)c3)nn2-c2ccccc2)[C@H](c2ccccc2)C1 CHEMBL4450020 IC50 1.7 nM
O=C1NC2(CC2)COc2ncc(F)cc2[C@H]2CNCCN2c2ccn3ncc1c3n2 CHEMBL5070835 IC50 1.7 nM
Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3942546 IC50 1.71 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(F)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL3899561 IC50 1.71 nM
O=C(NCc1cn[nH]c1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3890064 IC50 1.74 nM
CONC(=O)c1cnn2ccc(N3CCCC3c3cc(F)cnc3CO)nc12 CHEMBL3675958 IC50 1.77 nM
CNc1ccc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(F)cc3Cl)n(-c3ccccc3)n2)cn1 CHEMBL3904287 IC50 1.77 nM
CC(C)(C)NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)cnc3CO)nc12 CHEMBL3675955 IC50 1.8 nM
C[C@@H](CO)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3676045 IC50 1.8 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)N3CC[C@H](O)C3)c2n1 CHEMBL4763430 IC50 1.8 nM
O=C(NCc1cn[nH]c1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3952298 IC50 1.806 nM
Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CCC(O)CC4)c3n2)c1=O CHEMBL3937419 IC50 1.9 nM
CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C4CC4)cn3)c2)c2cnc(N)nc21 CHEMBL3671449 IC50 1.9 nM
C[C@@H](Nc1ccn2ncc(NC(=O)N3CC[C@H](O)C3)c2n1)c1cc(F)ccc1F CHEMBL4784645 IC50 1.9 nM
O=C(NCc1cn[nH]c1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3977553 IC50 1.936 nM
NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675908 IC50 1.95 nM
O=C(N[C@@H]1CCNC[C@@H]1F)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675937 IC50 1.95 nM
NC(=O)c1cc(NC(=O)c2cc(-c3cccc(N)n3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL4575703 IC50 1.99 nM
Cn1cc(/C=C2\C(=O)Nc3cccnc32)c2ccccc21 CHEMBL176544 IC50 2.0 nM
Cc1ccc(Sc2cnc(Nc3cccc(Br)n3)s2)cc1C(=O)N(C)CC#N CHEMBL254267 IC50 2.0 nM
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)n[nH]1 CHEMBL455920 EC50 2.0 nM
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc(OC(CO)CO)c2Cl)n[nH]1 CHEMBL515062 EC50 2.0 nM
CC1(C)C[C@H](c2cc(F)ccc2F)N(c2ccn3ncc(NC(=O)c4cnccn4)c3n2)C1 CHEMBL3947950 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccncc5)cnc43)cc2OC)cn1 CHEMBL3673486 IC50 2.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cnc(Oc3ccc(-c4cnc(N5CCCC5=O)s4)cc3)nc2)cc1C CHEMBL3964567 IC50 2.0 nM
Cn1ncc2cc(-n3nc(C(C)(C)C)cc3NC(=O)Nc3cnc(Oc4ccc(-c5cnc(N6CCCC6=O)s5)cc4)nc3)ccc21 CHEMBL3944160 IC50 2.0 nM
CCCNc1ncc(-c2ccc(Oc3ncc(NC(=O)Nc4cc(C(F)(F)F)ccc4Cl)cn3)cc2)s1 CHEMBL3970342 IC50 2.0 nM
CCCNc1ncc(-c2ccc(Oc3ncc(NC(=O)Nc4cc(C(F)(F)F)ccc4-n4ccc(C(F)(F)F)n4)cn3)cc2)s1 CHEMBL3940800 IC50 2.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3ccc(C(F)(F)F)n3)cn2)cc1 CHEMBL3906654 IC50 2.0 nM
Cn1nccc1-c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cc(Cl)cnc3N)cc2)nc1 CHEMBL3914679 IC50 2.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(C(F)(F)F)cc3Cl)cn2)cc1 CHEMBL3971434 IC50 2.0 nM
Nc1ncc(F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-c3ccccc3)cn2)cc1 CHEMBL3938236 IC50 2.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3cc(Cl)cn3)cn2)cc1 CHEMBL3967794 IC50 2.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(Cl)ccc3-n3ccc(C(F)(F)F)n3)cn2)cc1 CHEMBL3943636 IC50 2.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(C(F)(F)F)cc3C(F)(F)F)cn2)cc1 CHEMBL3976305 IC50 2.0 nM
CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5ccccc5)cn4)cc3)c2n1 CHEMBL3954827 IC50 2.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnc4[nH]ccc4c3)cc2)nc1)Nc1cc(C(F)(F)F)ccc1-c1cccnc1 CHEMBL3913818 IC50 2.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1 CHEMBL3989939 IC50 2.0 nM
CC(C)c1cc(C(=O)c2cccc(NC(=O)Nc3ccccc3)c2)c2c(N)ncnn12 CHEMBL4515809 IC50 2.0 nM
CC(C)c1cc(C(=O)c2cccc(NC(=O)Nc3ccc(OCc4ccccc4)cc3)c2)c2c(N)ncnn12 CHEMBL4467309 IC50 2.0 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Nc3ccc(F)cc3F)c2)c2c(N)ncnc21 CHEMBL4744936 IC50 2.0 nM
Fc1cc(Cl)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4780049 IC50 2.0 nM
Cc1nc(NC(=O)Cc2cccc(C(F)(F)F)c2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4787523 GI50 2.0 nM
Cc1nc(NC(=O)Cc2cccc(Cl)c2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4777826 GI50 2.0 nM
CC1(COc2ccnc(C#Cc3ccc4c5c(oc4c3)C(C)(C)c3cc(OCCN4CCOCC4)ccc3C5=O)c2)CC1 CHEMBL5195158 IC50 2.0 nM
CC1(C)c2cc(OCCN3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCCC4CC4)ccn3)ccc21 CHEMBL5191460 IC50 2.0 nM
O=C1Nc2ccc(NCc3cc(F)cc(F)c3)cc2/C1=C/c1cnc[nH]1 CHEMBL5412694 IC50 2.0 nM
O=C(NCc1cncnc1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3931763 IC50 2.02 nM
Nc1cccc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(F)cc3Cl)n(-c3ccccc3)n2)n1 CHEMBL3898571 IC50 2.06 nM
Cn1cc(CNC(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)cn1 CHEMBL3671150 IC50 2.1 nM
CC(C)(C)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12 CHEMBL3675914 IC50 2.1 nM
CNC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)cnc3OC)nc12 CHEMBL3676024 IC50 2.1 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@H](C)O)c2n1 CHEMBL3676027 IC50 2.1 nM
Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4(C)CC4)c3n2)c1=O CHEMBL3676099 IC50 2.1 nM
CS(=O)(=O)Nc1ccc(C(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)cc1 CHEMBL4114304 IC50 2.1 nM
CS(=O)(=O)c1ccc(F)cc1CNc1ccc2[nH]nc(-c3ccccn3)c2c1 CHEMBL4591039 IC50 2.1 nM
O=C1CCC(N2C(=O)c3cccc(NCCCCCC(=O)N4CCN(c5cccc(-c6cnc7ccc(N8CCC[C@@H]8c8cccc(F)c8)nn67)n5)CC4)c3C2=O)C(=O)N1 CHEMBL4742649 Kd 2.1 nM
CC1(C)c2cc(OCCN3CCNC(=O)C3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5199099 IC50 2.1 nM
CC(Nc1ccn2ncc(C(=O)NC3CCOCC3)c2n1)c1cccc(F)c1 CHEMBL5287060 IC50 2.1 nM
CC(C)(O)CNC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671145 IC50 2.15 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCN(S(C)(=O)=O)CC3)c2n1 CHEMBL3676033 IC50 2.2 nM
C[C@@H](O)CNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3676036 IC50 2.2 nM
C[C@H](NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)cn(C)c3=O)nc12)C1CC1 CHEMBL3676098 IC50 2.2 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)c1cnccn1 CHEMBL4108084 IC50 2.2 nM
O=C(Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12)N1C[C@@H](O)[C@H](O)C1 CHEMBL4112159 IC50 2.2 nM
COc1ccc(OC)c(NC(=O)Nc2nnc(SCc3cc(=O)n4cc(C)ccc4n3)s2)c1 CHEMBL4444901 IC50 2.2 nM
CN1CCN(c2ccc(NC(=O)[C@@H]3CCCN3c3nc(Nc4cc(F)cc(F)c4)ncc3Cl)cc2C(=O)N2CCSCC2)CC1 CHEMBL4854103 IC50 2.2 nM
CC1(C)c2cc(NS(C)(=O)=O)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC(F)(F)F)ccn3)ccc21 CHEMBL5205778 IC50 2.2 nM
CC(C)(C)NC(=O)c1cc(Cl)nc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)c1 CHEMBL5198357 IC50 2.2 nM
O=C(NCCN1CCOCC1)c1cnn2ccc(N3CCCC3c3cc(F)ccc3CO)nc12 CHEMBL3675931 IC50 2.25 nM
CC(CO)(CO)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675936 IC50 2.25 nM
CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3nc4ccccc4[nH]3)c2)c2cnc(N)nc21 CHEMBL3671404 IC50 2.25 nM
O=C(NCc1ccc(O)cn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3900941 IC50 2.27 nM
Cc1cccnc1NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671131 IC50 2.3 nM
Cn1nc(C(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)ccc1=O CHEMBL4106786 IC50 2.3 nM
CNC(=O)c1cnc(N)c(O[C@H]2CN(C(=O)Cc3ccc(OC(F)(F)F)cc3)CC2(F)F)c1 CHEMBL4207042 Kd 2.3 nM
COc1cc2c(=O)n(CC3CCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4284499 Kd 2.3 nM
CS(=O)(=O)Nc1ccccc1CNc1ccc2[nH]nc(-c3ccc(OC4CCNCC4)nc3)c2c1 CHEMBL4464600 IC50 2.3 nM
O=C1NC2(CC2)COc2ncc(F)cc2[C@H]2COCCN2c2ccn3ncc1c3n2 CHEMBL5080010 IC50 2.3 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 IC50 2.4 nM
C[C@H](O)CNC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3676035 IC50 2.4 nM
Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 CHEMBL3676058 IC50 2.4 nM
CC1(C)c2cc(NS(C)(=O)=O)ccc2C(=O)c2c1oc1cc(C#Cc3cc(C(=O)NC4CC4)ccn3)ccc21 CHEMBL5199353 IC50 2.4 nM
Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3908953 IC50 2.45 nM
O=C(NCc1ccno1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3951420 IC50 2.46 nM
COCCNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3676041 IC50 2.5 nM
CC[C@@H](CO)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3676046 IC50 2.5 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)Nc3ccc(O)cc3)c2n1 CHEMBL4795791 IC50 2.5 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 2.512 nM
CN1CCN(c2cc(Nc3cc(-c4cccc(F)c4)[nH]n3)nc(Sc3ccccc3)n2)CC1 CHEMBL4216563 pKd 2.512 nM
O=C(NC[C@H](O)CO)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3C(F)(F)F)nc12 CHEMBL3675938 IC50 2.53 nM
O=C(NCc1cn[nH]n1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3966169 IC50 2.53 nM
NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)cnc3CO)nc12 CHEMBL3675957 IC50 2.55 nM
O=C(NCc1cn[nH]c1)c1cc(NC(=O)c2cc(-c3ccc(F)cn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3971403 IC50 2.6 nM
CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C[C@H]2F)c1 CHEMBL4203759 Kd 2.6 nM
CC(C)(C)NC(=O)c1cc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)nc(C(F)(F)F)c1 CHEMBL5178903 IC50 2.6 nM
Cc1ccc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(F)cc3Cl)n(-c3ccccc3)n2)c(N)n1 CHEMBL3985346 IC50 2.65 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(C)C)c1 CHEMBL4447582 IC50 2.65 nM
C[C@@H]1COc2cn3ncc4c3nc2N1Cc1ccc(F)cc1OCCNC4=O CHEMBL5189357 IC50 2.67 nM
CCOc1nn(-c2ccccc2)c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C CHEMBL4090531 IC50 2.7 nM
Cc1cc(-n2cc(C3=CCOCC3)c3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)[nH]n1 CHEMBL4458269 IC50 2.7 nM
CC(C)(C)c1cc(NC(=O)CSc2nnnn2-c2ccccc2)n(-c2ccccc2)n1 CHEMBL4555143 IC50 2.7 nM
CC1(C)c2cc(OCCN3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CCC4)ccn3)ccc21 CHEMBL5193231 IC50 2.7 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(F)(F)F)c1)OCCCCC(=O)NCCN(C)c1ccc3ncc(n3n1)C#C2 CHEMBL5184321 IC50 2.7 nM
CCOc1nn(-c2ccccc2)c(NC(=O)N[C@H]2CN(CCOC)C[C@@H]2c2ccc(F)c(F)c2)c1C CHEMBL5424443 IC50 2.7 nM
COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C(F)(F)F)cn3)c2)c2cnc(N)nc21 CHEMBL3671425 IC50 2.78 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCCN(C)CC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5416521 IC50 2.79 nM
O=C(NCCn1ccnc1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671156 IC50 2.8 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@@H](C)O)c2n1 CHEMBL3676028 IC50 2.8 nM
C[C@@H](NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)cn(C)c3=O)nc12)C1CC1 CHEMBL3676097 IC50 2.8 nM
O=C(NCc1cc[nH]n1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3962599 IC50 2.8 nM
C[C@@H](Nc1ccn2ncc(-c3cnn(CC(C)(C)O)c3)c2n1)c1cc(F)ccc1F CHEMBL5184432 IC50 2.8 nM
CC1(C)c2cc(OCCN3CCCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5171199 IC50 2.8 nM
CC(C)(C)NC(=O)c1cc(C#N)nc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)c1 CHEMBL5173139 IC50 2.8 nM
O=C(N[C@H]1CC[C@H](O)CC1)c1cnc2ccc(NCc3cccc(F)c3)nn12 CHEMBL5287063 IC50 2.8 nM
Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3932808 IC50 2.84 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cnccc21 CHEMBL3975550 IC50 2.87 nM
CO[C@]1(CO)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL2113064 IC50 2.9 nM
C[C@H](NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12)C1CC1 CHEMBL3675998 IC50 2.9 nM
COc1ccc(-c2n[nH]c3ccc(NCc4ccccc4NS(C)(=O)=O)cc23)cn1 CHEMBL4555223 IC50 2.9 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCCCCCC(=O)N4CCN(c5cccc(-c6cnc7ccc(N8CCC[C@@H]8c8cccc(F)c8)nn67)n5)CC4)c3C2=O)C1=O CHEMBL4779847 Kd 2.9 nM
CC1(n2cc(C(=O)c3cncc(NC(=O)Cc4ccc(C(F)(F)F)cc4)c3)c3cncnc32)COC1 CHEMBL3671443 IC50 2.92 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C(F)(F)F)n3)c2)c2cncc(F)c21 CHEMBL3969718 IC50 2.92 nM
Cn1cnc(CNC(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)c1 CHEMBL3671149 IC50 2.95 nM
CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cncnc21 CHEMBL3671419 IC50 2.95 nM
CC1(O)CCC(NC(=O)c2cc(NC(=O)c3cc(-c4ccc(F)cn4)c(Cl)cc3Cl)n(-c3ccccc3)n2)CC1 CHEMBL3892259 IC50 2.96 nM
Nc1cc(NS(=O)(=O)c2ccc(F)cc2F)cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)c1 CHEMBL2152287 IC50 2.97 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 IC50 2.97 nM
Nc1ccc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(F)cc3Cl)n(-c3ccccc3)n2)cn1 CHEMBL3962152 IC50 2.98 nM
C[C@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL2113063 IC50 3.0 nM
CNC(=O)Nc1snc(SC(C)c2ccc(Cl)cc2)c1C(N)=O CHEMBL209466 IC50 3.0 nM
C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c(Cl)c(NC(CO)CO)n1)c1ccc(F)cc1 CHEMBL456322 EC50 3.0 nM
C[C@H](Nc1nc(NCCO)c(Cl)c(Nc2cc(C3CC3)[nH]n2)n1)c1ccc(F)cc1 CHEMBL456802 EC50 3.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 CHEMBL1231124 IC50 3.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(C#N)cc2F)n[nH]1 CHEMBL1774056 IC50 3.0 nM
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010872 IC50 3.0 nM
O=C1Nc2cc(Nc3cccc(NC(=O)c4cc(N5CCC(O)CC5)cc(C(F)(F)F)c4)c3)ccc2/C1=C/c1ccc[nH]1 CHEMBL2037213 IC50 3.0 nM
CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1 CHEMBL3109645 IC50 3.0 nM
OC1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1 CHEMBL3582442 IC50 3.0 nM
Fc1cccc([C@H]2CCCN2c2ccc3ncc(-c4ccccn4)n3n2)c1 CHEMBL3582439 IC50 3.0 nM
C[C@H](Nc1ccc2ncn(-c3cc(C4CC4)[nH]n3)c2n1)c1ccc(F)cn1 CHEMBL3659494 IC50 3.0 nM
C[C@H](Nc1ccc2ncn(-c3cc(C4CC4)[nH]n3)c2n1)c1ncc(F)cn1 CHEMBL2151319 IC50 3.0 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ncc(F)cn4)nc32)n[nH]1 CHEMBL3659497 IC50 3.0 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](CO)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151322 IC50 3.0 nM
CCOc1cc(-n2cnc3ccc(N[C@@H](CO)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL3659498 IC50 3.0 nM
CCOc1cc(-n2cnc3ccc(N[C@@H](C)c4ncc(F)cn4)nc32)n[nH]1 CHEMBL3659499 IC50 3.0 nM
CCOc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL3659500 IC50 3.0 nM
CC(C)Oc1cc(-n2cnc3cnc(N[C@@H](C)c4ncc(F)cn4)nc32)n[nH]1 CHEMBL2151323 IC50 3.0 nM
CCOc1cc(-n2cnc3ccc(N[C@@H](CC)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL3639583 IC50 3.0 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3ccc(=O)[nH]c3)c2n1 CHEMBL3676032 IC50 3.0 nM
Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CCC4)c3n2)c1=O CHEMBL3676092 IC50 3.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)c1ncccn1 CHEMBL4113187 IC50 3.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(CCN6CCOCC6)c5)ccc43)cc2OC)cc1 CHEMBL3673439 IC50 3.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccn(C)n5)cnc43)cc2OC)cn1 CHEMBL3673483 IC50 3.0 nM
COc1ccc(COc2ccc(C(C)n3c(N)nc4cc(-c5cnn(C)c5)ccc43)cc2OC)cn1 CHEMBL3678292 IC50 3.0 nM
Cc1cccc(-c2ncc(C(F)(F)F)cc2NC(=O)Nc2cnc(Oc3ccc(-c4cnc(N5CCCC5=O)s4)cc3)nc2)c1 CHEMBL3924506 IC50 3.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3cccn3)cn2)cc1 CHEMBL3894183 IC50 3.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(C(F)(F)F)cc3F)cn2)cc1 CHEMBL3900303 IC50 3.0 nM
Cc1cccc(-c2ccc(C(F)(F)F)cc2NC(=O)Nc2cnc(Oc3ccc(-c4cnn5ccc(N(C)C)nc45)cc3)nc2)c1 CHEMBL3982301 IC50 3.0 nM
CN(C)CCCc1cc(C(=O)c2cccc(NC(=O)Nc3ccc(Cl)cc3Cl)c2)c2c(N)ncnn12 CHEMBL4461026 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)COC(=O)c2ccc(-n3cnnn3)cc2)n(-c2ccccc2)n1 CHEMBL4447685 IC50 3.0 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(F)cc3F)c2)c2c(N)ncnc21 CHEMBL4748010 IC50 3.0 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnc(N)nc21 CHEMBL4748276 IC50 3.0 nM
Cc1nc(NC(=O)c2cccc(C(F)(F)F)c2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4796859 GI50 3.0 nM
Cc1nc(NC(=O)Nc2cccc(C(F)(F)F)c2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4788370 GI50 3.0 nM
CC1(C)c2cc(N3CC4(COC4)C3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5169941 IC50 3.0 nM
CC(Nc1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)CC3)c2n1)c1cccc(F)c1 CHEMBL5291020 IC50 3.0 nM
CO[C@H]1CC[C@H](NC(=O)c2cnc3ccc(NCc4cccc(F)c4)nn23)CC1 CHEMBL5287847 IC50 3.0 nM
O=C1Nc2ccc(NCc3cc(F)cc(F)c3)cc2/C1=C/c1cncs1 CHEMBL5435508 IC50 3.0 nM
Cc1nc[nH]c1/C=C1\C(=O)Nc2ccc(NCc3cc(F)cc(F)c3)cc21 CHEMBL5411653 IC50 3.0 nM
CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cnc(N)nc21 CHEMBL3661606 IC50 3.03 nM
O=C(NCc1cn[nH]c1)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3950400 IC50 3.05 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(C)(C)C)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5432219 IC50 3.06 nM
CC1(n2cc(C(=O)c3cncc(NC(=O)c4cccc(OC(F)(F)F)c4)c3)c3cncnc32)COC1 CHEMBL3671447 IC50 3.09 nM
CC(NC(=O)c1cnn2ccc(N3CC(O)CC3c3cccc(F)c3)nc12)C(F)(F)F CHEMBL3676081 IC50 3.1 nM
CC(C)Nc1nc(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)cs1 CHEMBL4115170 IC50 3.1 nM
Cc1cnc(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)cn1 CHEMBL4107063 IC50 3.1 nM
COc1cc(F)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4800232 IC50 3.1 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)N(C)CCNC(=O)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5195469 IC50 3.1 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C(F)(F)F)cn3)c2)c2cnc(N)nc21 CHEMBL3671436 IC50 3.11 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C(F)(F)F)cc3)c2)c2cnccc21 CHEMBL3957446 IC50 3.11 nM
Cc1ccc(CC(=O)Nc2cncc(C(=O)c3cn(C(C)(C)CO)c4nc(N)ncc34)c2)nc1 CHEMBL3671430 IC50 3.16 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 3.162 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 pKd 3.162 nM
Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3906935 IC50 3.174 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5421829 IC50 3.18 nM
CC1(NC(=O)c2cnn3ccc(N4CCC[C@@H]4c4cncc(F)c4)nc23)CC1 CHEMBL3675966 IC50 3.2 nM
CC(NC(=O)c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12)C1CC1 CHEMBL3675987 IC50 3.2 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3C(F)(F)F)nc12)N1CC[C@H](O)C1 CHEMBL3985415 IC50 3.2 nM
CC(C)N(C(=O)Nc1cnn2ccc(N[C@H](C)c3cc(F)ccc3F)nc12)C(C)C CHEMBL4783042 IC50 3.2 nM
CN(Cc1cccc(F)c1)c1ccn2ncc(C(=O)NC3CCOCC3)c2n1 CHEMBL5275881 IC50 3.2 nM
Nc1ncc2c(C(=O)c3cncc(NC(=O)Cn4cc(C(F)(F)F)nn4)c3)cn(C34CC(C3)C4)c2n1 CHEMBL3671470 IC50 3.21 nM
O=C(NCc1cccnn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3963169 IC50 3.21 nM
COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C(F)(F)F)n3)c2)c2cnc(N)nc21 CHEMBL3671423 IC50 3.22 nM
Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)nn1 CHEMBL3897605 IC50 3.22 nM
CC1(C)COc2cc(F)ccc2CN2CCOc3cn4ncc(c4nc32)C(=O)N1 CHEMBL5201536 IC50 3.23 nM
N#CCCNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3930567 IC50 3.25 nM
CS(=O)(=O)NCCNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3675924 IC50 3.3 nM
O=C(NC1CC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3OCC(O)CO)nc12 CHEMBL3676076 IC50 3.3 nM
CC1(C)c2cc(OCCN3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC(F)(F)F)ccn3)ccc21 CHEMBL5171966 IC50 3.3 nM
CC1(C)c2cc(OCCN3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4(CO)CC4)ccn3)ccc21 CHEMBL5173016 IC50 3.3 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5421783 IC50 3.3 nM
CC1(C)COc2cc(F)ccc2CN2CCCOC3=Cn4ncc(c4NC32)C(=O)N1 CHEMBL5180588 IC50 3.34 nM
Cc1c2cc(cc1C(=O)Nc1cc(N3CCC(N4CCOCC4)CC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5415833 IC50 3.35 nM
Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)ccc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL3975036 IC50 3.37 nM
O=C(Nc1cnn2ccc(N3CCC[C@H]3c3cc(F)ccc3F)nc12)N1CC[C@@H](O)C1 CHEMBL4856292 IC50 3.4 nM
CC1(C)c2cc(N3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5198427 IC50 3.4 nM
Nc1ccc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(F)cc3Cl)n(-c3ccccc3)n2)cn1 CHEMBL3904853 IC50 3.41 nM
O=C(NC1(CO)CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3933210 IC50 3.41 nM
CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671137 IC50 3.45 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnc(N)nc21 CHEMBL3666254 IC50 3.48 nM
CCOc1cccc(-c2nccc3c2cc(C(=O)O)n3CCOc2ccc(Cl)cc2)c1 CHEMBL3298164 Kd 3.5 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)c1cccc(Cl)n1 CHEMBL4114000 IC50 3.5 nM
N#Cc1cc(F)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4783132 IC50 3.5 nM
O=C1NCCOc2cc(F)ccc2CN2CCCOC3=Cn4ncc1c4NC32 CHEMBL5202081 IC50 3.54 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cncnc21 CHEMBL3661461 IC50 3.55 nM
Cc1c2cc(cc1C(=O)Nc1ccc(CN3CCN(C)CC3)c(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5420615 IC50 3.55 nM
CCc1cc(CN2CCN(C)CC2)cc(NC(=O)c2cccc(C#Cc3cnc4cnc(-c5ccc(N)cc5)cn34)c2C)c1 CHEMBL4579323 IC50 3.56 nM
O=C(NCCN1CCNC1=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3671152 IC50 3.6 nM
COCCOc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(N)=O)c2n1 CHEMBL3675964 IC50 3.6 nM
CCc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCC(O)CC3)c2n1 CHEMBL3971680 IC50 3.6 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283353 IC50 3.6 nM
O=C(NC1CCOCC1)c1cnn2ccc(NCc3cccc(F)c3)nc12 CHEMBL5271403 IC50 3.6 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cncnc21 CHEMBL3661616 IC50 3.61 nM
O=C(NCc1cnn[nH]1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3967617 IC50 3.63 nM
CNS(=O)(=O)c1ccc2c(c1)/C(=C/c1cn(C)c3ccc(OC)cc13)C(=O)N2 CHEMBL104519 IC50 3.66 nM
Fc1cc(F)cc(CCc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4800162 IC50 3.7 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C(F)(F)F)cn3)c2)c2cnc(N)nc21 CHEMBL3671435 IC50 3.75 nM
O=C1NCCOc2cc(F)ccc2CN2CCOc3cn4ncc1c4nc32 CHEMBL5208156 IC50 3.77 nM
COc1ccc2c(c1)c(/C=C1\C(=O)Nc3ccc(S(N)(=O)=O)cc31)cn2C CHEMBL104333 IC50 3.78 nM
C[C@H]1COc2cn3ncc4c3nc2N1Cc1ccc(F)cc1OCCNC4=O CHEMBL5193888 IC50 3.78 nM
O=C(Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12)N1CC[C@H](O)C1 CHEMBL3927707 IC50 3.8 nM
COc1ccccc1NC(=O)Nc1nnc(SCc2cc(=O)n3cccc(C)c3n2)s1 CHEMBL4577285 IC50 3.8 nM
Cc1cnc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)cc1C(=O)NC(C)(C)C CHEMBL5174514 IC50 3.8 nM
Cc1c(C(=O)NC(C)(C)C)ccnc1C#Cc1ccc2c3c(oc2c1)C(C)(C)c1cc(NS(C)(=O)=O)ccc1C3=O CHEMBL5203355 IC50 3.8 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3nc4ccc(Oc5ccnc(C(=O)NC)c5)cc4s3)cc2C(F)(F)F)CC1 CHEMBL4589373 IC50 3.81 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)c3cccc(OC(F)(F)F)c3)c2)c2cnccc21 CHEMBL3923369 IC50 3.85 nM
COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc21 CHEMBL3671421 IC50 3.88 nM
CC1(C)OCC(COc2cc(F)cc([C@H]3CCCN3c3ccn4ncc(C(=O)NC5CC5)c4n3)c2)O1 CHEMBL3676072 IC50 3.9 nM
COCc1ccc(OC(F)(F)F)c(CNC(=O)Nc2c(-c3ccccc3)nc3c(C)nccn23)c1 CHEMBL4861572 IC50 3.9 nM
CC1(C)c2cc(NS(C)(=O)=O)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5199002 IC50 3.9 nM
Fc1ccc(F)c([C@H]2CCCN2c2ccn3ncc(-c4cnn(C5COC5)c4)c3n2)c1 CHEMBL5203998 IC50 3.9 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C4CC4)n3)c2)c2cnc(N)nc21 CHEMBL3666257 IC50 3.92 nM
Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3984317 IC50 3.925 nM
CC(C)(CNS(C)(=O)=O)NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3675933 IC50 3.93 nM
CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Br)cn3)c2)c2cnc(N)nc21 CHEMBL3671405 IC50 3.93 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ncc4cc(F)ccc43)c2)c2cncnc21 CHEMBL3639603 IC50 3.95 nM
CC(C)Oc1cc(Nc2nc(NC(C)c3ccc(F)cn3)ncc2Cl)n[nH]1 CHEMBL2007421 pKi 3.981 nM
Cc1ccc(CSc2nc(Nc3cc(C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4217093 pKd 3.981 nM
CC1(C)O[C@@H](n2c3ccccc3c3c4c(c5c6ccccc6[nH]c5c32)CNC4=O)C[C@]1(O)CO CHEMBL365585 IC50 4.0 nM
CC1(C)O[C@@H](n2c3ccccc3c3c4c(c5c6ccccc6[nH]c5c32)CNC4=O)C[C@@]1(O)CO CHEMBL370493 IC50 4.0 nM
CC[C@@H](Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1 CHEMBL211160 IC50 4.0 nM
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc(NC(CO)CO)c2Cl)n[nH]1 CHEMBL456324 EC50 4.0 nM
OC[C@H](Nc1ncc(Cl)c(Nc2cc(C3CC3)[nH]n2)n1)c1ccc(F)cc1 CHEMBL514257 EC50 4.0 nM
CCN(CC)CCNC(=O)c1c[nH]c(/C=C2\C(=O)Nc3cc(Nc4cccc(NC(=O)c5cc(N6CCN(C)CC6)cc(C(F)(F)F)c5)c4)ccc32)c1 CHEMBL2037221 IC50 4.0 nM
CC(=O)NCc1ncc(NC(=O)c2ccc(C(F)(F)F)c(-c3ccn(C)n3)c2)c(-c2ccccc2)n1 CHEMBL3921392 IC50 4.0 nM
CC(C)Oc1cc(-n2cnc3cc(Cl)c(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL3659502 IC50 4.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)c1ccc(Cl)cn1 CHEMBL4107843 IC50 4.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)c1cc(Cl)ccn1 CHEMBL4111039 IC50 4.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12)c1ccccn1 CHEMBL4108424 IC50 4.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccccn5)cnc43)cc2OC)cn1 CHEMBL3673488 IC50 4.0 nM
CCNc1ncc(-c2ccc(Oc3ncc(NC(=O)Nc4cc(C(F)(F)F)cnc4-c4ccc(C)cc4)cn3)cc2)s1 CHEMBL3962074 IC50 4.0 nM
O=C(Nc1cnc(Oc2ccc(-c3cnc(N4CCCC4=O)s3)cc2)nc1)Nc1cc(C(F)(F)F)cnc1-c1ccccc1 CHEMBL3896203 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cnc(Oc3ccc(-c4cnc(N5CCCC5=O)s4)cc3)nc2)n(-c2ccc3c(c2)CCO3)n1 CHEMBL3916029 IC50 4.0 nM
CCCNc1ncc(-c2ccc(Oc3ncc(NC(=O)Nc4cc(F)ccc4F)cn3)cc2)s1 CHEMBL3974062 IC50 4.0 nM
CCCNc1ncc(-c2ccc(Oc3ncc(NC(=O)Nc4cc(C(F)(F)F)ccc4S(=O)(=O)N(C)C)cn3)cc2)s1 CHEMBL3934726 IC50 4.0 nM
Nc1ncc(C(F)(F)F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-n3ccc(C(F)(F)F)n3)cn2)cc1 CHEMBL3890123 IC50 4.0 nM
Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(C(F)(F)F)ccc3-c3ccccc3)cn2)cc1 CHEMBL3962675 IC50 4.0 nM
CN(C)S(=O)(=O)c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cc(C(F)(F)F)cnc3N)cc2)nc1 CHEMBL3975345 IC50 4.0 nM
CCNc1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(C(F)(F)F)ccc5-c5cccc(C)c5)cn4)cc3)c2n1 CHEMBL3892403 IC50 4.0 nM
Cc1ccccc1-c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cnn4ccc(N(C)C)nc34)cc2)nc1 CHEMBL3975658 IC50 4.0 nM
CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3891994 IC50 4.0 nM
CC1(C)c2cc(OCCN3CC4(COC4)C3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5197535 IC50 4.0 nM
CC(=O)NCc1ncc(NC(=O)c2ccc(C(F)(F)F)c(-c3cn(C)cn3)c2)c(-c2ccccc2)n1 CHEMBL5424164 IC50 4.0 nM
O=C(NC1CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3962859 IC50 4.02 nM
O=C(N[C@H]1CC[C@H](O)CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3954486 IC50 4.03 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)c3csc(C4CCC4)n3)c2)c2cncnc21 CHEMBL3666440 IC50 4.06 nM
COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(F)cc3)c2)c2cncnc21 CHEMBL3671415 IC50 4.08 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3Cl)nc12)N1CC[C@@H](O)C1 CHEMBL4112642 IC50 4.1 nM
O=C(NCC1(CO)COC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL4113176 IC50 4.14 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C(F)(F)F)cc3)c2)c2cncnc21 CHEMBL3661462 IC50 4.15 nM
Cn1cc(/C=C2\C(=O)Nc3ccc(S(N)(=O)=O)cc32)c2ccccc21 CHEMBL104279 IC50 4.17 nM
CC(C)(O)CNC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3CO)nc12 CHEMBL3675927 IC50 4.2 nM
NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3OCC(O)CO)nc12 CHEMBL3676077 IC50 4.2 nM
N#CC1(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)CC1 CHEMBL4107236 IC50 4.2 nM
Cc1cccc(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)n1 CHEMBL4107420 IC50 4.2 nM
Cc1ccc(-c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)cn1 CHEMBL5195033 IC50 4.2 nM
O=C(NCC1(O)COC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3930367 IC50 4.22 nM
C[C@@H](CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cncnc21 CHEMBL3661597 IC50 4.24 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCN(CCO)CC3)c2n1 CHEMBL3676030 IC50 4.3 nM
CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(CCN(C)C)C3 CHEMBL3671318 IC50 4.334 nM
O=C(NCCCO)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3899684 IC50 4.36 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc4ccccc4n3)c2)c2cnc(N)nc21 CHEMBL3671427 IC50 4.4 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cncc(F)c21 CHEMBL3957376 IC50 4.41 nM
O=C(N[C@@H]1CCOC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3898652 IC50 4.41 nM
O=C(N[C@H]1CC[C@@H](O)CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3919225 IC50 4.46 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 4.5 nM
Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NCC4CC4)c3n2)c1=O CHEMBL3676094 IC50 4.5 nM
CC(CO)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3981396 IC50 4.5 nM
Cn1ccc(-c2n[nH]c3ccc(NCc4cc(F)ccc4S(C)(=O)=O)cc23)n1 CHEMBL4566514 IC50 4.5 nM
CC1(C)c2cc(OCCN3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5186340 IC50 4.5 nM
O=C(Cc1ccc(C(F)(F)F)cc1)Nc1cncc(C(=O)c2cn(C3(CO)CC3)c3ncncc23)c1 CHEMBL3671402 IC50 4.53 nM
O=C(NC[C@@H](O)CO)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3C(F)(F)F)nc12 CHEMBL3675939 IC50 4.55 nM
COc1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(F)cc3Cl)n(-c3ccccc3)n2)ccn1 CHEMBL3967906 IC50 4.56 nM
CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C#N)cc3)c2)c2cnc(N)nc21 CHEMBL3671398 IC50 4.57 nM
O=C(Nc1ccc(F)cc1)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4111852 IC50 4.6 nM
CC(C)(C)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3940552 IC50 4.61 nM
C[C@H]1CN2Cc3ccc(F)cc3OCCNC(=O)c3cnn4cc(c2nc34)O1 CHEMBL5190535 IC50 4.61 nM
Cc1ccc(S(=O)(=O)Nc2cc(N)cc(-c3cnc4[nH]cc(-c5ccncc5)c4c3)c2)cc1 CHEMBL2152286 IC50 4.62 nM
Cn1cc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cncc(C(=O)c3cn(C)c4ncncc34)c2)cn1 CHEMBL3671467 IC50 4.64 nM
NC(=O)C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4113444 IC50 4.65 nM
O=C(NCC1CCOC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3950778 IC50 4.66 nM
O=C(NCc1ccno1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3954487 IC50 4.67 nM
O=C(NCc1ccncn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3965319 IC50 4.68 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C(F)(F)F)cc3)c2)c2cnc(N)nc21 CHEMBL3666248 IC50 4.69 nM
O=C(N[C@H]1C[C@H](O)C1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3942060 IC50 4.69 nM
O=C(NC1CCC(O)CC1)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3902802 IC50 4.7 nM
CN1CCN(CCNC(=O)c2cnn3ccc(N4CCCC4c4cc(F)ccc4F)nc23)CC1 CHEMBL3676040 IC50 4.7 nM
Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CCC(O)CC3)c2n1 CHEMBL3955007 IC50 4.7 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cnc(N)nc21 CHEMBL3666249 IC50 4.7 nM
COC(=O)C1(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)CC1 CHEMBL4111269 IC50 4.7 nM
O=C(O)C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4108051 IC50 4.7 nM
CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL4465781 IC50 4.7 nM
Fc1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)c(F)c1 CHEMBL5175892 IC50 4.7 nM
Cc1ncc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)[nH]1 CHEMBL3918364 IC50 4.71 nM
O=C(N[C@@H]1COC[C@H]1O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3966108 IC50 4.72 nM
C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3927785 IC50 4.73 nM
Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(-c3ccc(F)cn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3984178 IC50 4.75 nM
Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)N[C@@H]3CCC[C@H]3O)c2n1 CHEMBL3676064 IC50 4.8 nM
COc1ccc(NC(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)cc1 CHEMBL4107611 IC50 4.8 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc3c(ncn3C)c2N2CC[C@@H](N)C2)n1 CHEMBL5281003 IC50 4.8 nM
Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(-c3ccc(F)cn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3898851 IC50 4.81 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C(F)(F)F)n3)c2)c2cncnc21 CHEMBL3661491 IC50 4.86 nM
O=C(NCc1c[nH]nn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3979991 IC50 4.88 nM
CCN1CCN(c2cc(Nc3ncc(-c4ccncc4)s3)nc(C)n2)CC1 CHEMBL4513768 IC50 4.9 nM
O=C(NCc1cn[nH]c1)c1cc(NC(=O)c2cc(-c3ccc(F)cn3)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3979424 IC50 4.91 nM
Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(Cl)cc3Cl)n(-c3ccccc3)n2)nn1 CHEMBL3903947 IC50 4.92 nM
CCNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3930935 IC50 4.97 nM
O=C(NCc1cnccn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3984865 IC50 4.98 nM
OC1CCN(c2cccc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)n2)CC1 CHEMBL3582440 IC50 5.0 nM
Cn1cc(-c2cncc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)no4)cc3)n2)cn1 CHEMBL3596892 IC50 5.0 nM
C[C@H](Nc1ncc2ncn(-c3cc(C4CC4)[nH]n3)c2n1)c1ccc(F)cn1 CHEMBL3659496 IC50 5.0 nM
O=C(NCC(F)(F)F)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3676005 IC50 5.0 nM
O=C(Nc1ccccc1)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4112006 IC50 5.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cccnc5)cnc43)cc2OC)cn1 CHEMBL3673487 IC50 5.0 nM
COc1cc([C@@H](C)n2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)cc1 CHEMBL3678298 IC50 5.0 nM
O=C(NCCO)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3976264 IC50 5.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1 CHEMBL3989926 IC50 5.0 nM
C[C@@H]1CCc2ncc(F)cc2[C@H]2CCN(C2)c2ccn3ncc(c3n2)C(=O)N1 CHEMBL4798226 GI50 5.0 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(C1CCN(C)CC1)C3=O CHEMBL3671309 IC50 5.001 nM
O=C(NCc1cocn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3979739 IC50 5.01 nM
CC1(C)CC[C@H](c2cc(F)ccc2F)N1c1ccn2ncc(C(N)=O)c2n1 CHEMBL3675943 IC50 5.1 nM
CC(C)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3675968 IC50 5.1 nM
O=C(NCc1ccn[nH]1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3910586 IC50 5.117 nM
CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3948918 IC50 5.12 nM
O=C(NCc1ccon1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3975484 IC50 5.15 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cncnc21 CHEMBL3661492 IC50 5.16 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C(F)(F)F)n3)c2)c2cnc(N)nc21 CHEMBL3666256 IC50 5.18 nM
Cc1cnc2[nH]cc(C(=O)Nc3cncc(C(=O)c4cn(C(C)C)c5ncncc45)c3)c2c1 CHEMBL3666395 IC50 5.18 nM
CC1(NC(=O)c2cnn3ccc(N4CCCC4c4cncc(F)c4)nc23)CCC1 CHEMBL3675976 IC50 5.2 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)C1(C(F)(F)F)CC1 CHEMBL4113878 IC50 5.2 nM
NS(=O)(=O)c1ccc2c(c1)/C(=C/c1c[nH]c3ccc(O)cc13)C(=O)N2 CHEMBL4788922 IC50 5.22 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCC(=O)NCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5439833 IC50 5.29 nM
CC1(O)CN(C(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)C1 CHEMBL3675910 IC50 5.3 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(C(F)(F)F)cc3)c2)c2cnccc21 CHEMBL3980190 IC50 5.3 nM
C[C@]1(O)CC[C@H](NC(=O)c2cc(NC(=O)c3cc(-c4nc(N)c(F)cc4F)ccc3Cl)n(-c3ccccc3)n2)CC1 CHEMBL4555588 IC50 5.3 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C(F)(F)F)cn3)c2)c2cncc(F)c21 CHEMBL3912700 IC50 5.33 nM
CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(F)cc3)c2)c2cncnc21 CHEMBL3671420 IC50 5.34 nM
COCCOc1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC4)c3n2)c1 CHEMBL3675952 IC50 5.37 nM
C[C@@H]1COc2cn3ncc4c3nc2N1Cc1ccccc1O[C@@H](C)CNC4=O CHEMBL5196111 IC50 5.37 nM
O=C(Nc1ccc(F)cn1)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3675970 IC50 5.4 nM
CC(=O)Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12 CHEMBL4114141 IC50 5.4 nM
CC(=O)Nc1cc(N)cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)c1 CHEMBL2152289 IC50 5.41 nM
Cc1cc(C(F)(F)F)nn1CC(=O)Nc1cncc(C(=O)c2cn(C(C)C)c3ncncc23)c1 CHEMBL3661490 IC50 5.45 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)c3[nH]nc4ccccc34)c2)c2cncnc21 CHEMBL3671388 IC50 5.45 nM
COC[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3947413 IC50 5.45 nM
O=C(NCc1ccccn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3927344 IC50 5.46 nM
COc1ccc(NC(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)cc1 CHEMBL4114623 IC50 5.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 IC50 5.5 nM
CCc1ccnc(C(=O)Nc2cncc(C(=O)c3cn(C(C)C)c4ncncc34)c2)c1 CHEMBL3666427 IC50 5.51 nM
Nc1ncccc1CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3895250 IC50 5.55 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3nc4ccccc4[nH]3)c2)c2cnc(N)nc21 CHEMBL3671432 IC50 5.56 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C4CC4)n3)c2)c2cncc(F)c21 CHEMBL3900180 IC50 5.58 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)c(Cl)c3)c2)c2cnccc21 CHEMBL3930459 IC50 5.68 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@@H](O)CO)c2n1 CHEMBL3676021 IC50 5.7 nM
COc1ncccc1C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12 CHEMBL4112576 IC50 5.7 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3C(F)(F)F)nc12)N1CC[C@@H](O)C1 CHEMBL4107508 IC50 5.7 nM
Fc1cccc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4795019 IC50 5.7 nM
C[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3977894 IC50 5.78 nM
CC(C)NC(=O)c1cnn2ccc(N3C[C@@H](O)C[C@@H]3c3cccc(F)c3)nc12 CHEMBL3676082 IC50 5.8 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6cn[nH]c6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5418910 IC50 5.8 nM
CN1CCN(Cc2cc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc(C(F)(F)F)c2)CC1 CHEMBL5397846 IC50 5.8 nM
O=C(N[C@H]1C[C@@H](O)C1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3889897 IC50 5.83 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCC(=O)N(C)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5422195 IC50 5.83 nM
CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C#N)cn3)c2)c2cnc(N)nc21 CHEMBL3671406 IC50 5.9 nM
CC1(NC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)COC1 CHEMBL3970836 IC50 5.95 nM
Cn1nncc1CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3922194 IC50 5.96 nM
C[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3974598 IC50 5.97 nM
O=C(NCc1cnccn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3937255 IC50 5.97 nM
Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)C(=O)N(C1CCN(C)CC1)C2 CHEMBL3671320 IC50 5.992 nM
O=C1Nc2ccccc2/C1=C1\CCc2cc(O)ccc21 CHEMBL175321 IC50 6.0 nM
CS(=O)(=O)Nc1ccc(N/C=C2\C(=O)Nc3ccccc32)cc1 CHEMBL1794058 IC50 6.0 nM
C[C@H](Nc1ncc(Br)c(Nc2cc(C3CC3)[nH]n2)n1)c1ccc(F)cc1 CHEMBL456976 EC50 6.0 nM
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)ncc2Cl)n[nH]1 CHEMBL458286 EC50 6.0 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5C[C@@H](C)O[C@@H](C)C5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3408947 IC50 6.0 nM
O=C(Nc1ccc(-c2cnc3ccc(NCc4cccc(F)c4)nn23)cc1)C1CCOCC1 CHEMBL3582432 IC50 6.0 nM
CC[C@H](Nc1ccc2ncn(-c3cc(OC(C)C)[nH]n3)c2n1)c1ccc(F)cn1 CHEMBL3659501 IC50 6.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-c5cnn(C6CCNCC6)c5)ccc43)cc2OC)cn1 CHEMBL3673442 IC50 6.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccccc5)cnc43)cc2OC)cn1 CHEMBL3673481 IC50 6.0 nM
CCNc1ncc(-c2ccc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)cnc4-c4ccc(C)c(C)c4)cn3)cc2)s1 CHEMBL3929612 IC50 6.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 6.0 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2c(N)ncnc21 CHEMBL4790022 IC50 6.0 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc21 CHEMBL4212531 IC50 6.0 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccc(N)nc6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5425448 IC50 6.0 nM
Nc1ncc2c(C(=O)c3cncc(NC(=O)Cc4ccc(F)cn4)c3)cn(C34CC(C3)C4)c2n1 CHEMBL3671461 IC50 6.07 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCC(O)CO)c2n1 CHEMBL3676020 IC50 6.1 nM
O=C(NCCn1cncn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3960672 IC50 6.1 nM
O=C(NOC[C@@H](O)CO)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675963 IC50 6.13 nM
CC(=O)Nc1ccc(F)c(-c2ccc(Cl)c(C(=O)Nc3cc(C(N)=O)nn3-c3ccccc3)c2)n1 CHEMBL3889913 IC50 6.13 nM
O=C(NCc1cnco1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3961646 IC50 6.13 nM
Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3954365 IC50 6.14 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnccc21 CHEMBL3978653 IC50 6.16 nM
O=C(N[C@H]1COC[C@@H]1O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3890285 IC50 6.16 nM
O=C(NCC(F)CCl)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3675972 IC50 6.2 nM
Cc1cccnc1C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12 CHEMBL4114451 IC50 6.2 nM
C[C@@H]1CNC(=O)c2cnn3cc4c(nc23)N(Cc2ccc(F)cc2O1)[C@H](C)CO4 CHEMBL5196924 IC50 6.28 nM
CC(C)(C)C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4113479 IC50 6.3 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 6.31 nM
Cc1cc(C(F)(F)F)nn1CC(=O)Nc1cncc(C(=O)c2cn(C(C)(C)CO)c3c(F)cncc23)c1 CHEMBL3928158 IC50 6.32 nM
CC(CO)NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3942203 IC50 6.32 nM
O=C(NC1CC1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3903796 IC50 6.33 nM
CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(C1CCN(C)CC1)C3=O CHEMBL3671312 IC50 6.353 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(O)N(c1cccnc1)C3=O CHEMBL3671314 IC50 6.357 nM
O=C(NCC1(O)CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3942676 IC50 6.37 nM
C[C@@H](NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12)C1CC1 CHEMBL3675997 IC50 6.4 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(C)(C)C)c1 CHEMBL4569549 IC50 6.4 nM
CN1CCN(c2ccc(NC(=O)[C@@H]3CCCN3c3nc(Nc4cc(F)cc(F)c4)ncc3Cl)cc2C(=O)N(C)C)CC1 CHEMBL4853913 IC50 6.4 nM
O=C(NC1(CO)CC1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3935446 IC50 6.49 nM
CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1 CHEMBL3109646 EC50 6.5 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6cccnc6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5406952 IC50 6.5 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cncc(F)c21 CHEMBL3921687 IC50 6.53 nM
CC1(C)CC[C@H](c2cc(F)ccc2F)N1c1ccn2ncc(C(=O)NC3CC3)c2n1 CHEMBL3639748 IC50 6.6 nM
Cc1cnc(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cccc(F)c4)nc23)cn1 CHEMBL4113000 IC50 6.6 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C(F)(F)F)cc3)c2)c2cncc(F)c21 CHEMBL3914864 IC50 6.61 nM
O=C(NC1(CCO)COC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3961730 IC50 6.61 nM
O=C(NCc1ccccn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3909333 IC50 6.67 nM
CC1(O)CCC(NC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(F)cc3Cl)n(-c3ccccc3)n2)CC1 CHEMBL3941491 IC50 6.72 nM
Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 CHEMBL3676063 IC50 6.8 nM
CC(NC(=O)c1cnn2ccc(N3C(CO)CCC3c3cncc(F)c3)nc12)C(F)(F)F CHEMBL3676078 IC50 6.8 nM
COc1ccc(C)cc1NC(=O)Nc1nnc(SCc2cc(=O)n3cccc(C)c3n2)s1 CHEMBL4573890 IC50 6.8 nM
O=C(NCc1cnco1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3945591 IC50 6.82 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL4791998 IC50 6.89 nM
Cc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC(C)(C)C)c2n1 CHEMBL3676051 IC50 6.9 nM
COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc3sc(C)nc3c2N2CC[C@@H](N)C2)n1 CHEMBL5277241 IC50 6.9 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCOCC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5405759 IC50 6.9 nM
O=C(N[C@H]1CC[C@H](O)CC1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3935148 IC50 6.93 nM
CONC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cccc(F)c3)nc12 CHEMBL3675950 IC50 6.95 nM
Cc1nnc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)o1 CHEMBL3978831 IC50 6.96 nM
O=C1Nc2ccccc2/C1=C/Nc1ccc2[nH]c(=O)[nH]c2c1 CHEMBL1794057 IC50 7.0 nM
NC(=O)Nc1snc(S[C@@H]2CCCCc3ccccc32)c1C(N)=O CHEMBL211095 IC50 7.0 nM
CNC(=O)Nc1snc(SCc2ccc(Cl)cc2)c1C(N)=O CHEMBL378978 IC50 7.0 nM
C[C@H](Nc1ncc(F)c(Nc2cc(C3CC3)[nH]n2)n1)c1ccc(F)cn1 CHEMBL457393 EC50 7.0 nM
O=C(Nc1cccc(Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)c1)Nc1cccc(C(F)(F)F)c1 CHEMBL2037224 IC50 7.0 nM
CN1CCN(c2cc(C(=O)Nc3cccc(Nc4ccc5c(c4)NC(=O)/C5=C\c4ccc[nH]4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL2037211 IC50 7.0 nM
Cc1cn(-c2cc(C(=O)Nc3cccc(Nc4ccc5c(c4)NC(=O)/C5=C\c4ccc[nH]4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL2037209 IC50 7.0 nM
O=C1Nc2cc(Nc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2/C1=C/c1ccc[nH]1 CHEMBL2037208 IC50 7.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccc(P(C)(C)=O)nc5)ccc43)cc2OC)cc1 CHEMBL3673440 IC50 7.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(C#CCCO)cnc43)cc2OC)cn1 CHEMBL3678289 IC50 7.0 nM
COc1cc(C(C)n2cnc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)nc1 CHEMBL3678299 IC50 7.0 nM
Cn1cnc(-c2ccc(OC3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)CC3)c(C(N)=O)c2)c1 CHEMBL4215846 IC50 7.0 nM
C[C@@]1(C(=O)Nc2ccc(F)nc2)CCCN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL575448 IC50 7.0 nM
COc1cncc(-c2n[nH]c3ccc(NCc4ccccc4NS(C)(=O)=O)cc23)c1 CHEMBL4585431 IC50 7.0 nM
Cc1nc(NC(=O)CN2CCN(C)CC2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4794404 GI50 7.0 nM
O=C1Nc2ccc(NCc3cc(F)cc(Cl)c3)cc2/C1=C/c1ccc[nH]1 CHEMBL5418831 IC50 7.0 nM
O=C(NCc1cnccn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3942627 IC50 7.01 nM
CNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3961852 IC50 7.06 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)C(=O)NCCCCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5422091 IC50 7.08 nM
C[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3928864 IC50 7.09 nM
O=C(Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12)N1CCCCC1 CHEMBL4106554 IC50 7.1 nM
O=C(N[C@@H]1CCOC[C@H]1O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3910605 IC50 7.1 nM
COCc1cccc(-c2cc(C(=O)Nc3cc(C(=O)NCCO)nn3-c3ccccc3)c(Cl)cc2Cl)n1 CHEMBL3952980 IC50 7.195 nM
O=C(NCCCO)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3956535 IC50 7.21 nM
O=C(NC1COC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3979634 IC50 7.22 nM
O=C(N[C@H]1CC[C@@H](O)CC1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3892570 IC50 7.23 nM
O=C(NCc1ccnnc1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3907673 IC50 7.24 nM
Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(F)cc3Cl)n(-c3ccccc3)n2)nn1 CHEMBL3942166 IC50 7.26 nM
Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3975127 IC50 7.268 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)C(O)c3ccccc3)c2)c2cncnc21 CHEMBL3671396 IC50 7.3 nM
O=C(NCc1cnn[nH]1)c1cc(NC(=O)c2cc(-c3ccc(F)cn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3925931 IC50 7.3 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5185001 IC50 7.3 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(-c2ccccc2)c1 CHEMBL4438527 IC50 7.34 nM
O=C(NCc1cccnn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3914544 IC50 7.35 nM
O=C(NC1CC1)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3675929 IC50 7.4 nM
O=C(NCC(F)F)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3676008 IC50 7.4 nM
Cc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC(C)C)c2n1 CHEMBL3676052 IC50 7.4 nM
COc1cccc(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cccc(F)c4)nc23)n1 CHEMBL4111207 IC50 7.4 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3cccc(OC(F)(F)F)c3)c2)c2cnccc21 CHEMBL3976517 IC50 7.41 nM
CC(NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1)c1cncnc1 CHEMBL3895402 IC50 7.46 nM
O=C(N[C@H]1C[C@H](O)C1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3915218 IC50 7.46 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCN(C)C(=O)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5394378 IC50 7.47 nM
O=C(NCc1ccnnc1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3952307 IC50 7.49 nM
CC(C)(CO)C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4108478 IC50 7.5 nM
Cc1cc(Nc2nc(NCc3cc(F)ccc3F)nc3ccccc23)n[nH]1 CHEMBL5174615 IC50 7.5 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)C(=O)NCCCCCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5438621 IC50 7.5 nM
O=C(NCCn1ccnn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3964965 IC50 7.59 nM
Fc1cc(F)cc(Cc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4787950 IC50 7.6 nM
COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C4CC4)nn3)c2)c2cnc(N)nc21 CHEMBL3671426 IC50 7.62 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3nc4ccccc4n3)c2)c2cncnc21 CHEMBL3661502 IC50 7.63 nM
O=C(NCc1cocn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3956444 IC50 7.64 nM
CNC(=O)C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4109041 IC50 7.65 nM
COC(=O)C(=O)Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL4112494 IC50 7.65 nM
O=C(NC1CCNCC1(F)F)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3915459 IC50 7.66 nM
O=C(NCC1CC1)c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12 CHEMBL3675980 IC50 7.7 nM
Cn1cc(-c2ccc(O[C@@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C3)c(C(N)=O)n2)cn1 CHEMBL4211921 IC50 7.7 nM
COc1ccccc1NC(=O)Nc1nnc(SCc2cc(=O)n3ccc(C)cc3n2)s1 CHEMBL4524989 IC50 7.7 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4461048 IC50 7.75 nM
COc1cccc(-c2n[nH]c3ccc(NCc4ccccc4NS(C)(=O)=O)cc23)n1 CHEMBL4436442 IC50 7.8 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cncc(F)c21 CHEMBL3937136 IC50 7.85 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(C)C)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5410884 IC50 7.85 nM
O=C(O)c1cc2c(-c3cccc4ccccc34)nccc2n1Cc1noc(-c2ccccc2)n1 CHEMBL3298162 Kd 7.9 nM
COc1ccc(OC)c(NC(=O)Nc2nnc(SCc3cc(=O)n4ccc(C)cc4n3)s2)c1 CHEMBL4461600 IC50 7.9 nM
O=C(Nc1ccc(N2CCOCC2)c(C(=O)N2CCSCC2)c1)[C@@H]1CCCN1c1nc(Nc2cc(F)cc(F)c2)ncc1Cl CHEMBL4856927 IC50 7.9 nM
Fc1ccc(-c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nc23)cc1 CHEMBL5181767 IC50 7.9 nM
Cn1nc(N)cc1CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3954937 IC50 7.91 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 7.943 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 7.943 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 7.943 nM
COc1ccccc1-c1cc(/C=C2\C(=O)Nc3ncc(Br)cc32)cc(Br)c1O CHEMBL176857 IC50 8.0 nM
O=C1Nc2ccccc2/C1=C/Nc1ccc(-n2cncn2)cc1 CHEMBL1794056 IC50 8.0 nM
CNC(=O)Nc1snc(SC2CCc3cc(Cl)ccc32)c1C(N)=O CHEMBL211883 IC50 8.0 nM
CCNC(=O)O[C@@H](C)[C@H]1c2ccccc2-c2c3c(c4c([nH]c5ccccc54)c21)CNC3=O CHEMBL427901 IC50 8.0 nM
Cc1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL2037226 IC50 8.0 nM
C[C@@H](NC(=O)c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12)C(F)(F)F CHEMBL3676003 IC50 8.0 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@H](O)CO)c2n1 CHEMBL3676017 IC50 8.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3Cl)nc12)N1CC[C@H](O)C1 CHEMBL3964207 IC50 8.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccncc5)ccc43)cc2OC)cc1 CHEMBL3673438 IC50 8.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(N5CCC[C@H]5C(=O)O)cnc43)cc2OC)cn1 CHEMBL3673461 IC50 8.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 8.0 nM
Cn1cnc(-c2cnc(N)c(O[C@@H]3CN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C[C@H]3F)c2)c1 CHEMBL4213038 IC50 8.0 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)N(C)CCN(C)C)c2n1 CHEMBL4759162 IC50 8.0 nM
Cc1nc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4789313 GI50 8.0 nM
O=C1Nc2ccccc2/C1=C/Nc1ccc(-n2nccn2)cc1 CHEMBL5275659 IC50 8.0 nM
O=C1Nc2ccc(NCc3cc(F)cc(Br)c3)cc2/C1=C/c1ccc[nH]1 CHEMBL5393979 IC50 8.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5396972 IC50 8.08 nM
O=C(NCc1c[nH]nn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3904254 IC50 8.09 nM
O=C(NC1CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)ccc2Cl)n(-c2cccc(O)c2)n1 CHEMBL3955042 IC50 8.09 nM
CS(=O)(=O)c1cccc(CC(=O)Nc2cncc(C(=O)c3cn(C45CC(C4)C5)c4nc(N)ncc34)c2)c1 CHEMBL3671468 IC50 8.11 nM
Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)cn1 CHEMBL3906307 IC50 8.12 nM
O=C(NCc1ccno1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3971279 IC50 8.14 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCNC(=O)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5429379 IC50 8.21 nM
Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(Cl)cc3Cl)n(-c3ccccc3)n2)cn1 CHEMBL3896188 IC50 8.23 nM
Nc1nc(-c2ccc(Cl)c(C(=O)Nc3cc(C(=O)NCCCO)nn3-c3ccccc3)c2)c(F)cc1F CHEMBL4452467 IC50 8.23 nM
Cc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4161036 IC50 8.24 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 8.3 nM
O=C(Nc1ccccc1)Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12 CHEMBL4108297 IC50 8.3 nM
CC(C)(C)OC(=O)N1CCN(C(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)CC1(C)C CHEMBL4115579 IC50 8.3 nM
O=C(NCc1ccon1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3933154 IC50 8.34 nM
Nc1cc(OCCN2CCOCC2)cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)c1 CHEMBL2152283 IC50 8.36 nM
CC1(O)CCC(NC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)CC1 CHEMBL3912891 IC50 8.36 nM
O=C(NC1CCOCC1)c1cnc2ccc(NCc3cccc(F)c3)nn12 CHEMBL5291305 IC50 8.4 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(C(F)(F)F)c(F)c3)c2)c2cnccc21 CHEMBL3976094 IC50 8.49 nM
COc1ccc2[nH]cc(/C=C3\C(=O)Nc4ccc(S(N)(=O)=O)cc43)c2c1 CHEMBL106226 IC50 8.49 nM
CC(C)[C@@H](CO)NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12 CHEMBL3676047 IC50 8.5 nM
Cn1ccc(C(=O)Nc2cnn3ccc(N4CCC[C@@H]4c4cccc(F)c4)nc23)n1 CHEMBL4111614 IC50 8.5 nM
O=C(N[C@H]1CCOC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3930393 IC50 8.51 nM
Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CCC3)c2n1 CHEMBL3676053 IC50 8.6 nM
CC1(NC(=O)c2cnn3ccc(N4[C@H](CO)CC[C@@H]4c4cncc(F)c4)nc23)CC1 CHEMBL3676079 IC50 8.6 nM
O=C(NCC1CCOC1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3937886 IC50 8.6 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(NCCS(C)(=O)=O)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5433434 IC50 8.6 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C#N)cc3)c2)c2cnc(N)nc21 CHEMBL3666262 IC50 8.62 nM
CC(C)(CF)NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3675946 IC50 8.65 nM
Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)Nc4cccnc4)c3n2)c1=O CHEMBL3676093 IC50 8.7 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3C(F)F)nc12)N1CC[C@H](O)C1 CHEMBL3894479 IC50 8.7 nM
COC[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3912928 IC50 8.7 nM
Cn1cc(-c2ccc(OC3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)CC3)c(C(N)=O)c2)cn1 CHEMBL4204174 IC50 8.7 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6cnn(CCO)c6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5422637 IC50 8.7 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc21 CHEMBL3666246 IC50 8.71 nM
O=C(NCC1(O)COC1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3956053 IC50 8.71 nM
O=C(NCc1cn[nH]c1)c1cc(NC(=O)c2cc(-c3ncccc3F)ccc2Cl)n(-c2ccccc2)n1 CHEMBL3959978 IC50 8.74 nM
Fc1ccccc1CNc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1 CHEMBL4783102 IC50 8.8 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C4CC4)n3)c2)c2cncnc21 CHEMBL3661485 IC50 8.81 nM
O=C(NC1CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3905830 IC50 8.87 nM
O=C(NCc1cccnn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3943397 IC50 8.88 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3cc(C4CC4)n[nH]3)c2n1 CHEMBL3676104 IC50 8.9 nM
CC1(O)CN(C(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)C1 CHEMBL4113459 IC50 8.9 nM
O=C(NC1CCOCC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3917758 IC50 8.9 nM
COC[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3934727 IC50 8.96 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1276446 IC50 9.0 nM
CCC(Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1 CHEMBL425066 IC50 9.0 nM
C=CCNC(=O)O[C@@H](C)[C@H]1c2ccccc2-c2c3c(c4c([nH]c5ccccc54)c21)CNC3=O CHEMBL254555 IC50 9.0 nM
C[C@H](Nc1nc(NC[C@@H](O)CO)c(Cl)c(Nc2cc(C3CC3)[nH]n2)n1)c1ccc(F)cc1 CHEMBL456801 EC50 9.0 nM
Cc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL2037225 IC50 9.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(Nc4cccc(NC(=O)c5cc(N6CCN(C)CC6)cc(C(F)(F)F)c5)c4)ccc32)c(C)c1C(=O)O CHEMBL2037222 IC50 9.0 nM
Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cc(C5CC5)nn4-c4ccccc4)nn3)cc2)cn1 CHEMBL3298267 IC50 9.0 nM
O=C(NC1(C(F)(F)F)CC1)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12 CHEMBL3675973 IC50 9.0 nM
CCc1cc(NC(=O)c2cnn3ccc(N4CCCC4c4cc(F)cnc4OC)nc23)[nH]n1 CHEMBL3676105 IC50 9.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccc(F)cc5)cnc43)cc2OC)cn1 CHEMBL3673482 IC50 9.0 nM
COCCNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3980356 IC50 9.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(F)c(F)c2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5079048 IC50 9.0 nM
CC1(NC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(Cl)cc3Cl)n(-c3ccccc3)n2)COC1 CHEMBL3961246 IC50 9.09 nM
O=C(NCc1ccncn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3894154 IC50 9.1 nM
CCc1ccc(NC(=O)Nc2nnc(SCc3cc(=O)n4cccc(C)c4n3)s2)cc1 CHEMBL4466061 IC50 9.1 nM
CNC(=O)C(C#N)NC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3902577 IC50 9.13 nM
CCNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3907403 IC50 9.17 nM
CN(C)S(=O)(=O)c1ccc2c(c1)/C(=C/c1cn(C)c3ccc(O)cc13)C(=O)N2 CHEMBL4798255 IC50 9.17 nM
CN1CCN(C(=O)c2cc(NC(=O)[C@@H]3CCCN3c3nc(Nc4cc(F)cc(F)c4)ncc3Cl)ccc2N2CCOCC2)CC1 CHEMBL4852786 IC50 9.2 nM
CNC(=O)C1(NC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)CC1 CHEMBL3970377 IC50 9.3 nM
CC(CO)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cncnc21 CHEMBL3661627 IC50 9.36 nM
Cc1ncc(CNC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(Cl)cc3Cl)n(-c3ccccc3)n2)[nH]1 CHEMBL3985003 IC50 9.36 nM
CNC(=O)CNC(=O)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3952185 IC50 9.37 nM
O=C(NC1CC1)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)cc(OCCN4CCOCC4)c3)nc12 CHEMBL3675960 IC50 9.38 nM
Nc1cc(NS(=O)(=O)c2ccccc2)cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)c1 CHEMBL2152285 IC50 9.4 nM
CC(C)(N)CNC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12 CHEMBL3675934 IC50 9.4 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCNC(=O)OC(C)(C)C)c2n1 CHEMBL3676015 IC50 9.4 nM
O=C(Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12)N1CC(O)C1 CHEMBL4113889 IC50 9.4 nM
Nc1cccc(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)ccc3Cl)n(-c3ccccc3)n2)n1 CHEMBL3948987 IC50 9.42 nM
Cc1n[nH]c(CNC(=O)c2cc(NC(=O)c3cc(-c4ncccc4F)c(Cl)cc3Cl)n(-c3ccccc3)n2)n1 CHEMBL3936597 IC50 9.46 nM
CN(c1ccc(CC(=O)Nc2cncc(C(=O)c3cn(C(C)(C)CO)c4nc(N)ncc34)c2)cc1)S(C)(=O)=O CHEMBL3671431 IC50 9.47 nM
C[C@@H]1COc2cn3ncc4c3nc2N1Cc1ccc(Cl)cc1O[C@@H](C)CNC4=O CHEMBL5202709 IC50 9.47 nM
O=C(Cn1ccc(C(F)(F)F)n1)Nc1cncc(C(=O)c2cn(C3(CO)CC3)c3ncncc23)c1 CHEMBL3671403 IC50 9.48 nM
CC1(n2cc(C(=O)c3cncc(NC(=O)Cc4cccc(C(F)(F)F)c4)c3)c3cncnc32)COC1 CHEMBL3671444 IC50 9.5 nM
O=C(NCc1ncccn1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3937196 IC50 9.51 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C#N)cc3)c2)c2cnccc21 CHEMBL3960311 IC50 9.54 nM
O=C(NCCOCCO)c1cc(NC(=O)c2cc(-c3ncccc3F)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3973508 IC50 9.58 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnccc21 CHEMBL3930913 IC50 9.64 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C(F)(F)F)cn3)c2)c2cncc(F)c21 CHEMBL3952175 IC50 9.66 nM
Cc1cc(Cl)c(C(=O)Nc2cc(C(=O)NCC(C)(C)O)nn2-c2ccccc2)cc1-c1ncccc1F CHEMBL3911127 IC50 9.67 nM
COCCNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3934347 IC50 9.67 nM
O=C(N[C@H]1CC[C@@H](O)CC1)c1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3931190 IC50 9.71 nM
CC1(O)CCC(NC(=O)c2cc(NC(=O)c3cc(-c4ccccn4)c(F)cc3Cl)n(-c3ccccc3)n2)CC1 CHEMBL3978304 IC50 9.77 nM
N#Cc1ccc(CC(=O)Nc2cncc(C(=O)c3cn(C45CC(C4)C5)c4nc(N)ncc34)c2)cc1 CHEMBL3671471 IC50 9.79 nM
CC(C)(C)NC(=O)Nc1cnc2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nn12 CHEMBL4108618 IC50 9.8 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C(F)(F)F)nn3)c2)c2cnccc21 CHEMBL3910951 IC50 9.86 nM
CC(C)c1cn(CC(=O)Nc2cncc(C(=O)c3cn(C(C)(C)CO)c4ccncc34)c2)nn1 CHEMBL3951602 IC50 9.89 nM
COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCC(C)(C)O)c2n1 CHEMBL3676029 IC50 9.9 nM
O=C(NC1COC1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3910261 IC50 9.9 nM
O=C(NCCn1cncn1)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3958931 IC50 9.94 nM
CNc1ncccc1CNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1 CHEMBL3940562 IC50 9.98 nM