C[C@H]1CNC(=O)c2cnn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1 CHEMBL4298138 IC50 0.01 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.123 nM
O=C1NC2(CC2)COc2ncc(F)cc2[C@H]2CCCCN2c2ccn3ncc1c3n2 CHEMBL5093999 IC50 0.2 nM
O=C1NC2(CC2)COc2ncc(F)cc2[C@H]2CNCCN2c2ccn3ncc1c3n2 CHEMBL5070835 IC50 0.2 nM
O=C1NC2(CC2)COc2ncc(F)cc2[C@H]2COCCN2c2ccn3ncc1c3n2 CHEMBL5080010 IC50 0.2 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1 CHEMBL3889654 IC50 0.2 nM
CN(C)CCCOc1ccc2c(NCCc3cnc(NC(=O)Nc4cccc(Cl)c4)s3)ncnc2c1 CHEMBL4864729 IC50 0.21 nM
C[C@H]1CNC(=O)c2ncn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1 CHEMBL5400169 IC50 0.211 nM
C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(c3n2)C(=O)N1 CHEMBL4297627 IC50 0.5 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)cnc43)cc2OC)cc1 CHEMBL3673452 IC50 0.503 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 IC50 0.525 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 0.7 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2)cc1 CHEMBL1977148 pKi 0.7943 nM
O=C(Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1)C1CC1 CHEMBL3545365 IC50 0.83 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 1.0 nM
Fc1cccc([C@H]2CCCN2c2ccc3ncc(-c4ccccn4)n3n2)c1 CHEMBL3582439 IC50 1.0 nM
Cn1cc(-c2ccc(O[C@@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C3)c(C(N)=O)n2)cn1 CHEMBL4211921 IC50 1.0 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2c(N)ncnc21 CHEMBL4790022 IC50 1.0 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnc(N)nc21 CHEMBL3666254 IC50 1.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@H]3c3cc(F)ccc3F)nc12)N1CC[C@@H](O)C1 CHEMBL4856292 IC50 1.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5088153 Ki 1.0 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL1983268 IC50 1.0 nM
Cn1cnc(-c2cnc(O[C@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C[C@H]3F)c(C(N)=O)c2)c1 CHEMBL4210892 IC50 1.1 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 1.259 nM
CC(C)Oc1cc(Nc2nc(NC(C)c3ccc(F)cn3)ncc2Cl)n[nH]1 CHEMBL2007421 pKi 1.585 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(CCN(C)C)C3=O CHEMBL3671311 IC50 1.585 nM
CC(C)N(C(=O)Nc1cnn2ccc(N(C)[C@H](C)c3cc(F)ccc3F)nc12)C(C)C CHEMBL4743163 IC50 1.9 nM
Fc1cc(F)cc(Cc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4787950 IC50 1.9 nM
OC1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1 CHEMBL3582442 IC50 2.0 nM
OC1CCN(c2cccc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)n2)CC1 CHEMBL3582440 IC50 2.0 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnc(N)nc21 CHEMBL4748276 IC50 2.0 nM
C[C@@H](Nc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1)c1cc(F)cc(F)c1 CHEMBL4792981 IC50 2.0 nM
CNC(=O)c1cnc(N)c(O[C@H]2CN(C(=O)Cc3ccc(OC(F)(F)F)cc3)CC2(F)F)c1 CHEMBL4207042 IC50 2.2 nM
Cn1cnc(-c2ccc(OC3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)CC3)c(C(N)=O)c2)c1 CHEMBL4215846 IC50 2.3 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)N3CC[C@H](O)C3)c2n1 CHEMBL4763430 IC50 2.3 nM
C[C@@H](Nc1ccn2ncc(NC(=O)N3CC[C@H](O)C3)c2n1)c1cc(F)ccc1F CHEMBL4784645 IC50 2.3 nM
Cc1cc(Nc2nc(NCc3cc(F)ccc3F)nc3ccccc23)n[nH]1 CHEMBL5174615 IC50 2.5 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 2.512 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 2.512 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)Nc3ccc(O)cc3)c2n1 CHEMBL4795791 IC50 2.6 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(C1CCN(C)CC1)C3=O CHEMBL3671309 IC50 2.601 nM
Cc1nc(NC(=O)CN2CCN(C)CC2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4794404 IC50 2.62 nM
Fc1cc(F)cc(COc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4782515 IC50 2.7 nM
Fc1cc(F)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4785469 IC50 2.7 nM
Fc1cccc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4795019 IC50 2.7 nM
Cc1cc(C(=O)NC(C)(C)C)cc(C#Cc2ccc3c4c(oc3c2)C(C)(C)c2cc(NS(C)(=O)=O)ccc2C4=O)n1 CHEMBL4457566 IC50 2.8 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(C)C)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5410884 IC50 2.83 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)C[C@@H]4C)cc(C(F)(F)F)c2)cn1 CHEMBL4553037 IC50 2.9 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(C)C)c1 CHEMBL4447582 IC50 2.95 nM
N#Cc1ccc(-c2cnc3ccc(N4CCC[C@@H]4c4cccc(F)c4)nn23)cc1 CHEMBL3582438 IC50 3.0 nM
O=C(Nc1ccc(-c2cnc3ccc(NCc4cccc(F)c4)nn23)cc1)C1CCOCC1 CHEMBL3582432 IC50 3.0 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cncnc21 CHEMBL3661464 IC50 3.0 nM
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc21 CHEMBL4212531 IC50 3.0 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 3.162 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 3.162 nM
CC(C)N(C(=O)Nc1cnn2ccc(N[C@H](C)c3cc(F)ccc3F)nc12)C(C)C CHEMBL4783042 IC50 3.3 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 3.4 nM
O=C(Nc1cccc(-n2cc(CN3CCN(CCO)CC3)nn2)c1)c1cc(F)cc(F)c1 CHEMBL5436505 IC50 3.8 nM
CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C[C@H]2F)c1 CHEMBL4203759 IC50 3.9 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 3.981 nM
NS(=O)(=O)c1ccc(-c2cnc3ccc(NCc4cccc(F)c4)nn23)cc1 CHEMBL3582433 IC50 4.0 nM
CC(C)n1cc(C(=O)c2ccnc(NC(=O)Nc3ccc(F)cc3F)c2)c2c(N)ncnc21 CHEMBL4744936 IC50 4.0 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C4CC4)n3)c2)c2cnc(N)nc21 CHEMBL3666257 IC50 4.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCCN(C)CC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5416521 IC50 4.05 nM
CCc1cc(CN2CCN(C)CC2)cc(NC(=O)c2cccc(C#Cc3cnc4cnc(-c5ccc(N)cc5)cn34)c2C)c1 CHEMBL4579323 IC50 4.1 nM
COc1ccc2c(c1)c(/C=C1\C(=O)Nc3ccc(S(N)(=O)=O)cc31)cn2C CHEMBL104333 IC50 4.1 nM
CNS(=O)(=O)c1ccc2c(c1)/C(=C/c1cn(C)c3ccc(OC)cc13)C(=O)N2 CHEMBL104519 IC50 4.25 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5421783 IC50 4.3 nM
Cc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4161036 IC50 4.35 nM
CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326006 IC50 4.38 nM
N#Cc1cc(F)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4783132 IC50 4.5 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3cc(C(F)(F)F)ccc23)n[nH]1 CHEMBL5196903 IC50 4.5 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccc(N)nc6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5425448 IC50 4.5 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C3CC3)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5423601 IC50 4.51 nM
Fc1cc(Cl)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4780049 IC50 4.9 nM
Cn1cc(-c2ccc(OC3CCN(C(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)c(C(N)=O)c2)cn1 CHEMBL4218103 IC50 5.0 nM
CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C(F)(F)F)n3)c2)c2cnccc21 CHEMBL3955023 IC50 5.0 nM
O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1 CHEMBL3989939 IC50 5.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 5.012 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 5.012 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 5.012 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 5.012 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 5.012 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 5.012 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 5.012 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(C)(C)C)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5432219 IC50 5.22 nM
Fc1cc(F)cc(Sc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4797186 IC50 5.4 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5421829 IC50 5.48 nM
Fc1cc(F)cc(OCc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4777099 IC50 5.6 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCC(=O)NCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5439833 IC50 5.6 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4461048 IC50 5.71 nM
N=C(N)c1ccc(/N=N/c2c(N)ncc3ccc(Br)cc23)cc1 CHEMBL4091670 IC50 5.9 nM
Cc1cc(F)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4796220 IC50 5.9 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCN(C)C(=O)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5394378 IC50 5.95 nM
N#Cc1ccc(-c2cnc3ccc(NCc4cccc(F)c4)nn23)cc1 CHEMBL3582429 IC50 6.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2cccnc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5077662 IC50 6.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(F)c(F)c2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5079048 IC50 6.0 nM
O=C1Nc2ccc(NCc3cc(F)ccc3F)cc2/C1=C/c1cnc[nH]1 CHEMBL5431992 IC50 6.0 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(C)(C)C)c1 CHEMBL4569549 IC50 6.1 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 6.31 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 6.31 nM
Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(-c2ccccc2)c1 CHEMBL4438527 IC50 6.52 nM
Cn1cc(/C=C2\C(=O)Nc3ccc(S(N)(=O)=O)cc32)c2ccccc21 CHEMBL104279 IC50 6.86 nM
CC1(C)c2cc(OCCN3CCOCC3)ccc2C(=O)c2c1oc1cc(C#Cc3cc(OCC4CC4)ccn3)ccc21 CHEMBL5186340 IC50 6.9 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 7.0 nM
Cc1cc(NC(=O)Nc2cc(C3CC3)nn2-c2ccccc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5076895 IC50 7.0 nM
Cc1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL2037226 IC50 7.0 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCNC(=O)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5429379 IC50 7.06 nM
CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)n[nH]1 CHEMBL457614 IC50 7.2 nM
COc1cc(F)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4800232 IC50 7.5 nM
Fc1cc(F)cc(Oc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4778721 IC50 7.8 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6cn[nH]c6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5418910 IC50 7.8 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 7.943 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 7.943 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 7.943 nM
N#Cc1ccc(-c2cnc3ccc(N4CCCC4c4cccc(F)c4)nn23)cc1 CHEMBL3582436 IC50 8.0 nM
Fc1cc(Br)cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4787602 IC50 8.0 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6cccnc6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5406952 IC50 8.0 nM
CN1CCN(Cc2cc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc(C(F)(F)F)c2)CC1 CHEMBL5397846 IC50 8.1 nM
Cn1cc(-c2ccc(OC3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)CC3)c(C(N)=O)n2)cn1 CHEMBL4208510 IC50 8.4 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283353 IC50 8.4 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C(F)(F)F)c1)OCCCCC(=O)NCCN(C)c1ccc3ncc(n3n1)C#C2 CHEMBL5184321 IC50 8.5 nM
Cc1c2cc(cc1C(=O)Nc1cc(N3CCC(N4CCOCC4)CC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5415833 IC50 8.51 nM
COc1ccc2[nH]cc(/C=C3\C(=O)Nc4ccc(S(N)(=O)=O)cc43)c2c1 CHEMBL106226 IC50 8.82 nM
Cc1c(C#Cc2cnc3cnc(-c4ccncc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4454061 IC50 8.84 nM
CC1(C)c2[nH]nc(NC(=O)c3ccc(N4CCOCC4)cc3)c2CN1Cc1cc(F)cc(F)c1 CHEMBL4862017 IC50 9.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccccc2F)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5075779 IC50 9.0 nM
COc1ccc(F)cc1CNc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2 CHEMBL5402022 IC50 9.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCOCC3)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5405759 IC50 9.17 nM
CC(C)c1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4168305 Kd 9.3 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)C(=O)NCCCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5408929 IC50 9.45 nM
Fc1cc(F)cc(NCc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4786112 IC50 9.5 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)NCCC(=O)N(C)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5422195 IC50 9.56 nM
CN(C)S(=O)(=O)c1ccc2c(c1)/C(=C/c1cn(C)c3ccc(O)cc13)C(=O)N2 CHEMBL4798255 IC50 9.72 nM
CN(Cc1cc(F)cc(F)c1)c1ccc2[nH]nc(/C=C/c3ccccn3)c2c1 CHEMBL4779607 IC50 9.9 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 10.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 10.0 nM
CC1(C)c2[nH]nc(NC(=O)c3ccc(N4CCOCC4)cc3)c2CN1Cc1cccc(F)c1F CHEMBL4866306 IC50 10.0 nM
Cc1cn(-c2cc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc(C(F)(F)F)c2)cn1 CHEMBL5421249 IC50 10.1 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C6CCOCC6)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5191797 IC50 10.3 nM
O=C(Nc1cccc(-n2cc(CN3CCC[C@H]3CO)nn2)c1)c1cc(F)cc(F)c1 CHEMBL5394749 IC50 10.6 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)C(=O)NCC(=O)NCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5394049 IC50 10.84 nM
N#Cc1ccc(-c2cnc3ccc(N4CCCCC4c4cccc(F)c4)nn23)cc1 CHEMBL3582434 IC50 11.0 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4c3CN(Cc3cc(F)cc(F)c3)C4(C)C)cc2)CC1 CHEMBL4849505 IC50 11.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccccc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5084219 IC50 11.0 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)N(C)CCNC(=O)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5195469 IC50 11.0 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)C(=O)NCCCCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5422091 IC50 11.29 nM
Cc1c2cc(cc1C(=O)Nc1ccc(CN3CCN(C)CC3)c(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5420615 IC50 11.44 nM
Cc1c(C#Cc2cnc3cnccn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4467462 IC50 11.46 nM
CN1CCN(Cc2cc(NC(=O)c3cccc(C#Cc4cnc5cnccn45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL4587651 IC50 11.48 nM
COc1ccc2c(c1)c(/C=C1\C(=O)Nc3ccc(S(=O)(=O)N(C)C)cc31)cn2C CHEMBL322153 IC50 11.67 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6cnn(CCO)c6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5422637 IC50 11.8 nM
Cc1ccc2c(Nc3cc(C)[nH]n3)nc(NCc3ccc(F)cc3F)nc2c1 CHEMBL5186552 IC50 12.0 nM
Fc1cc(F)cc(CCc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4800162 IC50 12.4 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 12.59 nM
Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)c(Cl)c1 CHEMBL1997892 pKi 12.59 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 12.59 nM
CCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1979516 pKi 12.59 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6cnn(C7CCOCC7)c6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5414386 IC50 12.7 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 13.0 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4c3CN(Cc3cccc(F)c3F)C4(C)C)cc2)CC1 CHEMBL4856835 IC50 13.0 nM
O=C1Nc2ccc(NCc3cc(F)cc(F)c3)cc2/C1=C/c1cnc[nH]1 CHEMBL5412694 IC50 13.0 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccccc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5198364 IC50 13.02 nM
C(=C/c1n[nH]c2ccc(NCc3ccccc3)cc12)\c1ccccn1 CHEMBL4795806 IC50 13.2 nM
Cc1c2cc(cc1C(=O)Nc1cc(C(C)(C)C)nn1-c1ccc(Cl)cc1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5410147 IC50 13.5 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 14.0 nM
Cc1cc(CN2CCN(C)CC2)cc(NC(=O)c2cccc(C#Cc3cnc4cnc(-c5ccc(N)cc5)cn34)c2C)c1 CHEMBL4446455 IC50 14.55 nM
Cc1c2cc(cc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5396972 IC50 14.66 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2cccc(F)c2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5092454 IC50 15.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 15.85 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccn1 CHEMBL1992306 pKi 15.85 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cnc2c(-c3ccc4c(c3)OCO4)cnn12 CHEMBL1977134 pKi 15.85 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 15.85 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)N(C)CCN(C)C)c2n1 CHEMBL4759162 IC50 16.0 nM
Cc1c(C#Cc2cnc3cnc(-c4ccccc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4469795 IC50 16.8 nM
CC(C)c1c2cc(-c3ccnc(Nc4ccc5c(N6CCN(C)CC6)ccnc5c4)n3)ccc2nn1C CHEMBL4856177 IC50 16.9 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)no3)cc2)NC1=O CHEMBL5092127 IC50 17.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N[C@@H]1CCN(c2ccc3ncc(-c4ccccn4)n3n2)C1 CHEMBL5415236 IC50 17.0 nM
Cc1nc([C@](C)(O)CO)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128069 IC50 18.0 nM
CN1CCN(c2ccc(NCc3cn(-c4cccc(CNc5cc(F)cc(F)c5)c4)nn3)cc2C(=O)N2CCOCC2)CC1 CHEMBL5406821 IC50 18.4 nM
N#Cc1ccc(-c2cnc3ccc(N4CCOCC4c4cccc(F)c4)nn23)cc1 CHEMBL3582435 IC50 19.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 19.0 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=S)N3CC[C@H](O)C3)c2n1 CHEMBL4777109 IC50 19.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Nc3ncnc4c3OC(C)(C)C(=O)N4)c(C)c2)cc1 CHEMBL5077319 IC50 19.0 nM
COc1cccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982924 pKi 19.95 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 19.95 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 19.95 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 19.95 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 19.95 nM
CN(Cc1ccccc1)c1ccc2ncc(-c3ccc(C#N)cc3)n2n1 CHEMBL3580682 IC50 20.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 20.0 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)C(=O)NCCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5433110 IC50 20.26 nM
C[C@@H](Nc1ccn2ncc(NC(=O)N3CCCC(CO)C3)c2n1)c1cc(F)ccc1F CHEMBL4762176 IC50 21.0 nM
CN1CCN(c2cccc(Nc3ncc(Cl)c(NCc4cccc(F)c4)n3)c2)CC1 CHEMBL5209091 IC50 21.0 nM
O=C(N[C@@H]1CCCNC1)c1cccc(Nc2ncc(Cl)c(NCc3cccc(F)c3)n2)c1 CHEMBL5206946 IC50 21.0 nM
Cc1c(C#Cc2cnc3ccc(N4CCC[C@H](N)C4)nn23)cccc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1 CHEMBL5198838 IC50 21.3 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 23.0 nM
COc1cc(Nc2ncnc3c2OC(C)(C)C(=O)N3)ccc1NC(=O)Nc1cc(C(C)(C)C)nn1-c1ccccc1 CHEMBL5094782 IC50 23.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc3ccccc3c2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5079503 IC50 23.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3cc(Cl)ccc23)n[nH]1 CHEMBL5184749 IC50 23.0 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)N3CCCC(CO)C3)c2n1 CHEMBL4791453 IC50 25.0 nM
CN(c1cc(F)cc(F)c1)c1ccc2[nH]nc(/C=C/c3ccccn3)c2c1 CHEMBL4776591 IC50 25.0 nM
Cn1cc(C=C2C(=O)Nc3cccnc32)c2ccccc21 CHEMBL1516890 pKi 25.12 nM
COc1cc(-c2ccc3[nH]nc(C(=O)Nc4ccccc4)c3c2)ccc1O CHEMBL2007002 pKi 25.12 nM
CC(C)OC1=NNC(=O)C1=Cc1c[nH]c2ccccc12 CHEMBL1989029 pKi 25.12 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)N3CCN(C)CC3)c2n1 CHEMBL4782487 IC50 26.0 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)C(=O)NCCCCCCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5438621 IC50 27.75 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccccc3)cc2)NC1=O CHEMBL5094232 IC50 28.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(C(F)(F)F)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5092079 IC50 28.0 nM
CN(Cc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1)c1cc(F)cc(F)c1 CHEMBL4777347 IC50 28.7 nM
O=C1Nc2cc(Nc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2/C1=C/c1ccc[nH]1 CHEMBL2037208 IC50 29.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O CHEMBL459850 EC50 30.0 nM
C[C@H](Nc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1)c1cc(F)cc(F)c1 CHEMBL4780099 IC50 30.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3OC)n2)cc1 CHEMBL4874046 IC50 30.09 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(OC(F)(F)F)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5079988 IC50 31.0 nM
O=C(NC1CCCNC1)c1cccc(Nc2ncc(Cl)c(N3CCCC3c3cccc(F)c3)n2)c1 CHEMBL5208586 IC50 31.0 nM
Cc1cc(C)cc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1964687 pKi 31.62 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 31.62 nM
CNc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL1981410 pKi 31.62 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 31.62 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 32.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(F)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5089872 IC50 32.0 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5c(c4)OCO5)n[nH]3)cc2)CC1 CHEMBL4456471 IC50 33.37 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 34.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1)NC(=O)CCCCCCN[C@H]1CCCN(C1)c1ccc3ncc(n3n1)C#C2 CHEMBL5184043 IC50 34.8 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2c(F)c(F)c(F)c(F)c2F)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5078713 IC50 35.0 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(NC(=O)N3CC(O)C3)c2n1 CHEMBL4745371 IC50 36.0 nM
CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)ccc4n3)cn2)CC1 CHEMBL5283628 IC50 36.0 nM
Cc1conc1NC(=O)N[C@@H]1CCN(c2ccc3ncc(-c4ccccn4)n3n2)C1 CHEMBL5422461 IC50 36.8 nM
Cc1c2cc(cc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1)NOCCCCC(=O)N[C@H]1CCCN(C1)c1ccc3ncc(n3n1)C#C2 CHEMBL5194130 IC50 37.8 nM
C[C@H](c1cc(F)ccc1F)N(C)c1ccn2ncc(Nc3c(N4CC[C@H](O)C4)c(=O)c3=O)c2n1 CHEMBL4788418 IC50 39.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 39.81 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 39.81 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 39.81 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 39.81 nM
O=C(Nc1cccc(Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)c1)Nc1cccc(C(F)(F)F)c1 CHEMBL2037224 IC50 40.0 nM
OCc1ccc(-c2cnc3ccc(NCc4cccc(F)c4)nn23)cc1 CHEMBL3582431 IC50 40.0 nM
CN1CCN(Cc2cc(NC(=O)[C@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc(C(F)(F)F)c2)CC1 CHEMBL5416220 IC50 40.2 nM
COc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccccc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5088966 IC50 41.0 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5c(c4)CCO5)n[nH]3)cc2)CC1 CHEMBL4473123 IC50 41.62 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877347 IC50 42.1 nM
Cc1c2cc(cc1NC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5404881 IC50 42.4 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5c(c4)OCCO5)n[nH]3)cc2)CC1 CHEMBL4470728 IC50 43.07 nM
Fc1ccc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)cc1 CHEMBL4778234 IC50 44.2 nM
CN1CCN(Cc2cc(NC(=O)c3cccc(C#Cc4cnc5cnccn45)c3Cl)cc(C(F)(F)F)c2)CC1 CHEMBL4531144 IC50 44.58 nM
O=C(N[C@H]1CCCNC1)c1cccc(Nc2ncc(Cl)c(NCc3cccc(F)c3)n2)c1 CHEMBL5183516 IC50 45.0 nM
C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 CHEMBL3286830 IC50 46.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@@H](Nc3cncnc3)C4)cc(C(F)(F)F)c2)cn1 CHEMBL4472914 IC50 46.3 nM
COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1 CHEMBL5201102 IC50 48.0 nM
CNC1CCN(C(=O)c2cccc(Nc3ncc(Cl)c(NCc4cccc(F)c4)n3)c2)CC1 CHEMBL5189901 IC50 49.0 nM
CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 CHEMBL4645565 IC50 50.1 nM
Cn1nc(C(F)(F)F)c2c(=O)c3cc(Cl)ccc3n(O)c21 CHEMBL207400 pKi 50.12 nM
CCN(CC)CC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2001257 pKi 50.12 nM
Cc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)n[nH]c12 CHEMBL1973937 pKi 50.12 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL220057 pKi 50.12 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 50.12 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 50.12 nM
C[C@@H](Nc1ccn2ncc(NC(=S)N3CC[C@H](O)C3)c2n1)c1cc(F)ccc1F CHEMBL4778629 IC50 51.0 nM
Fc1ccccc1CNc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1 CHEMBL4783102 IC50 52.0 nM
C[C@@H](Nc1ccn2ncc(NC(=O)Nc3ccc(O)cc3)c2n1)c1cc(F)ccc1F CHEMBL4780959 IC50 53.0 nM
Cn1cc(-c2cc3ncnc(Nc4ccc(CC(=O)Nc5cc(C(C)(C)C)nn5C)cc4)c3s2)cn1 CHEMBL4868797 IC50 55.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3nccnc3N(C)S(C)(=O)=O)n2)cc1 CHEMBL3137331 IC50 57.83 nM
O=C(c1cccc(-c2n[nH]c3ncc(Cc4cc(F)ccc4F)cc23)c1)N1CCCC(O)C1 CHEMBL5282566 IC50 58.0 nM
Cc1ccc2c(Nc3cc(C4CC4)[nH]n3)nc(NCc3ccc(F)cc3F)nc2c1 CHEMBL5206613 IC50 61.0 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 63.1 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 63.1 nM
CSc1cc(Nc2ncnc3c2OC(C)(C)C(=O)N3)ccc1NC(=O)Nc1cc(C(C)(C)C)nn1-c1ccccc1 CHEMBL5075039 IC50 66.0 nM
Cc1cc(C#Cc2cnc3cnccn23)cc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)c1 CHEMBL4467427 IC50 66.98 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 68.0 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccccc3)c(F)c2)NC1=O CHEMBL5086753 IC50 70.0 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)NC1=O CHEMBL5088342 IC50 74.0 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccccc3)c3ccccc23)NC1=O CHEMBL5083108 IC50 74.0 nM
CN1CCC(NC(=O)c2cccc(Nc3ncc(Cl)c(NCc4cccc(F)c4)n3)c2)CC1 CHEMBL5208676 IC50 74.0 nM
COc1ccccc1CNc1ccc2ncc(-c3ccc(C#N)cc3)n2n1 CHEMBL3582430 IC50 75.0 nM
CC1(C)c2[nH]nc(NC(=O)c3cccc(N4CCOCC4)c3)c2CN1Cc1cc(F)cc(F)c1 CHEMBL4862580 IC50 75.0 nM
Fc1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)c(F)c1 CHEMBL5175892 IC50 75.0 nM
O=C(c1cccc(-c2n[nH]c3ncc(Cc4cc(F)ccc4F)cc23)c1)N1CCC[C@H](O)C1 CHEMBL5276362 IC50 76.0 nM
C[C@@H](Nc1ccn2ncc(NC(=O)N3CC(O)C3)c2n1)c1cc(F)ccc1F CHEMBL4758658 IC50 78.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 79.43 nM
CC(=O)N1CCN(C2CCC(n3nc(-c4ccc(NC(=O)c5cc6ccccc6n5C)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1972584 pKi 79.43 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 79.43 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 pKi 79.43 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 79.43 nM
COc1ccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)cc1 CHEMBL1997764 pKi 79.43 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 79.43 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 79.43 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 82.0 nM
CCC(CO)NC(=O)Nc1cnn2ccc(N[C@H](C)c3cc(F)ccc3F)nc12 CHEMBL4754926 IC50 82.0 nM
O=C(c1cccc(-c2n[nH]c3ncc(Cc4cc(F)ccc4F)cc23)c1)N1CCC[C@@H](O)C1 CHEMBL5276440 IC50 83.0 nM
Cc1cc(NC(=O)Nc2cc(-c3ccccc3)nn2-c2ccccc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5093101 IC50 89.0 nM
COCCOc1cc(-n2c(=O)[nH]c(=O)n(-c3cccc(C)c3)c2=O)ccc1Oc1ccccc1 CHEMBL4462161 EC50 90.0 nM
CCC(CO)NC(=O)Nc1cnn2ccc(N(C)[C@H](C)c3cc(F)ccc3F)nc12 CHEMBL4787769 IC50 92.0 nM
Cc1cc(C(=O)Nc2cccc(Nc3ccc4c(c3)NC(=O)/C4=C\c3ccc[nH]3)c2)cc(N2CCN(C)CC2)c1 CHEMBL2037210 IC50 97.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 100.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)c1 CHEMBL185569 pKi 100.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 100.0 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1cccc(F)c1F CHEMBL1974416 pKi 100.0 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 100.0 nM
N#Cc1ccc(-c2cnc3ccc(NCc4ccccc4)nn23)cc1 CHEMBL3582427 IC50 100.0 nM
CC(C)c1ccn2ncnc(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)N5CCC(CCN6CCN(c7ccc8c(c7)C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)CC5)CC4)CC3)c12 CHEMBL4749646 IC50 100.0 nM
CN1CCN(c2cccc(C(=O)Nc3n[nH]c4c3CN(Cc3cc(F)cc(F)c3)C4(C)C)c2)CC1 CHEMBL4858347 IC50 100.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3Cl)n2)cc1 CHEMBL4850588 IC50 102.12 nM
Cc1c2cc(cc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1)OCCCCC(=O)NCCN(C)c1ccc3ncc(n3n1)C#C2 CHEMBL5183862 IC50 102.2 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3C3CCCCC3)cc2)NC1=O CHEMBL5076205 IC50 104.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1)NC(=O)CCCCCCCN[C@H]1CCCN(C1)c1ccc3ncc(n3n1)C#C2 CHEMBL5178374 IC50 109.8 nM
Fc1cc(F)cc(Nc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4799340 IC50 112.7 nM
O=C(Nc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1)c1cc(F)cc(F)c1 CHEMBL4792043 IC50 118.6 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccccc3)c(C(F)(F)F)c2)NC1=O CHEMBL5092552 IC50 119.0 nM
Cc1cc(Nc2ncnc3c2OC(C)(C)C(=O)N3)ccc1NC(=O)Nc1cc(C(C)(C)C)nn1-c1ccccc1 CHEMBL5077305 IC50 119.0 nM
COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 CHEMBL261849 Kd 120.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 120.0 nM
Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL3685796 IC50 120.0 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)NC1=O CHEMBL5086738 IC50 123.0 nM
Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1 CHEMBL1965033 pKi 125.89 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 125.89 nM
O=C1Nc2ccccc2Nc2nnc(I)cc21 CHEMBL1977346 pKi 125.89 nM
CCc1c(C#Cc2cnc3cnccn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4473502 IC50 129.0 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2)NC1=O CHEMBL5083239 IC50 132.0 nM
COc1cc(-c2cn(CC(=O)Nc3cc(C4CC4)nn3-c3ccccc3)nn2)ccc1-n1cnc(C)c1 CHEMBL3298266 IC50 142.1 nM
C[C@@H](Nc1ccn2ncc(NC(=O)N(C)CCN(C)C)c2n1)c1cc(F)ccc1F CHEMBL4778061 IC50 145.0 nM
C[C@@H](Nc1ccn2ncc(NC(=O)N3CCN(C)CC3)c2n1)c1cc(F)ccc1F CHEMBL4749323 IC50 151.0 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc5ccccc5s4)n[nH]3)cc2)CC1 CHEMBL4571608 IC50 156.7 nM
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 CHEMBL3884319 IC50 157.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 158.49 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 158.49 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 pKi 158.49 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 158.49 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 158.49 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1ccc(Cl)cc1 CHEMBL1998829 pKi 158.49 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 158.49 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](N(C)c3cncnc3)C4)cc(C(C)(C)C)c2)cn1 CHEMBL4472004 IC50 158.9 nM
Fc1cc(CNc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)cc(C(F)(F)F)c1 CHEMBL4794286 IC50 160.4 nM
COCCOc1cc(-n2c(=O)[nH]c(=O)n(-c3ccc(C)cc3)c2=O)ccc1Oc1ccccc1 CHEMBL4529332 EC50 170.0 nM
COCCOc1cc(-n2c(=O)[nH]c(=O)n(-c3cccc(Cl)c3)c2=O)ccc1Oc1ccccc1 CHEMBL4455143 EC50 180.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 190.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 190.0 nM
O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(Br)c2)c(=O)n1-c1ccccc1 CHEMBL4538772 EC50 190.0 nM
CSc1c[nH]c2ncnc(NCCCO)c12 CHEMBL2000114 pKi 199.53 nM
O=C(Nc1nc2ccccc2n1CCCO)c1cccc([N+](=O)[O-])c1 CHEMBL210887 pKi 199.53 nM
Nc1ccc(-c2csc3c(C=Cc4nc5ccccc5[nH]4)cnc(N)c23)cc1 CHEMBL1988300 pKi 199.53 nM
O=C1NC(=S)SC1=C1C(=O)Nc2ccc(Br)cc21 CHEMBL2001920 pKi 199.53 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 199.53 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 199.53 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 199.53 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 199.53 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 200.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 200.0 nM
O=C1NCCCCn2cc(cn2)-c2cnc3ccc(cc3c2)CCn2nc(ccc2=O)-c2ccc1c(C(F)(F)F)c2 CHEMBL5181396 IC50 203.9 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 210.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](N(C)c3cncnc3)C4)cc(C(C)C)c2)cn1 CHEMBL4441609 IC50 215.4 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 220.0 nM
Cn1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c1=O CHEMBL4574315 EC50 220.0 nM
N#Cc1cccc(-c2cnc3ccc(NCc4ccccc4)nn23)c1 CHEMBL3582428 IC50 230.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 250.0 nM
Cc1nn(C)c2c1c(=O)c1cc(Cl)ccc1n2OCC(C)C CHEMBL1977814 pKi 251.19 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 251.19 nM
O=C(CCC(=O)Nc1cc(C(F)(F)F)ccc1Cl)NN=Cc1c[nH]c2ccccc12 CHEMBL1994308 pKi 251.19 nM
O=C(Nc1ccc(-c2ccc(=O)[nH]n2)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL2007124 pKi 251.19 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 251.19 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 251.19 nM
Brc1ccc2[nH]nc(-c3ccccc3)c2c1 CHEMBL1994074 pKi 251.19 nM
Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn(C5CCN(C)CC5)c4)nc3cc2F)cn1 CHEMBL5288931 IC50 270.0 nM
CCN(c1cncnc1)[C@@H]1Cc2ccc(C(=O)Nc3cc(-n4cnc(C)c4)cc(C(F)(F)F)c3)cc2C1 CHEMBL4570381 IC50 278.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(Cl)cc(C(F)(F)F)c1)NC(=O)CCCCCN[C@H]1CCCN(C1)c1ccc3ncc(n3n1)C#C2 CHEMBL5198765 IC50 285.7 nM
N#Cc1cnc(NC(=O)Nc2ccc3cc(C(=O)O)ccc3c2)cn1 CHEMBL560813 pKi 316.23 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 316.23 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 316.23 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4c(c3)OCO4)csc12 CHEMBL1993243 pKi 316.23 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 pKi 316.23 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 316.23 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc(OCCCn4cccc4)c4[nH]nc(N)c34)cc2)c1 CHEMBL2007266 pKi 316.23 nM
Cc1ccc(-c2cc(-c3cc(Br)ccc3O)[nH]c(=O)c2C#N)s1 CHEMBL1997193 pKi 316.23 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 316.23 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 316.23 nM
Nc1nonc1-n1nnc(C(=O)NN=Cc2ccncc2)c1-c1ccccc1 CHEMBL1419458 pKi 316.23 nM
Cc1cc(C)c2oc(Nc3ccc(-c4cccc(C(N)=O)c4N)cc3F)nc2c1 CHEMBL1990884 pKi 316.23 nM
CCOC(=O)C1=c2sc(=Cc3ccco3)c(=O)n2C(N)=C(C#N)C1c1ccco1 CHEMBL1999112 pKi 316.23 nM
O=C(NCc1ccccc1)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL1972142 pKi 316.23 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 316.23 nM
COc1ccc(-c2cc(NC(=O)c3ccc(NC4CCN(C)CC4)cc3)[nH]n2)cc1OC CHEMBL4437322 IC50 323.6 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 330.0 nM
COCCOc1cc(-n2c(=O)[nH]c(=O)n(-c3ccc(Cl)cc3)c2=O)ccc1Oc1ccccc1 CHEMBL4455810 EC50 330.0 nM
CC(C)Oc1cc(-n2c(=O)[nH]c(=O)n(-c3ccccc3)c2=O)ccc1Oc1ccccc1 CHEMBL4472787 EC50 330.0 nM
CCc1cc(NC(=O)c2ccc3c(c2)C[C@H](N(C)c2cncnc2)C3)cc(-n2cnc(C)c2)c1 CHEMBL4541139 IC50 364.2 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 380.0 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 398.11 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 pKi 398.11 nM
CC(C)NC1=NNC(=O)C1=Cc1cc2ccccc2[nH]1 CHEMBL1988692 pKi 398.11 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 398.11 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 398.11 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 398.11 nM
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O CHEMBL483158 pKi 398.11 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 398.11 nM
C[C@@H](Nc1ccn2ncc(Nc3c(N4CC[C@H](O)C4)c(=O)c3=O)c2n1)c1cc(F)ccc1F CHEMBL4756923 IC50 412.0 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5c(c4)OC(F)(F)O5)n[nH]3)cc2)CC1 CHEMBL4440687 IC50 442.0 nM
Fc1cc(F)cc(C#Cc2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4779366 IC50 455.4 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3C(C)(C)C)cc2)NC1=O CHEMBL5085052 IC50 459.0 nM
O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OC3CCOC3)c2)c(=O)n1-c1ccccc1 CHEMBL4467829 EC50 480.0 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5nccn5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5439768 IC50 495.5 nM
Cn1cc(-c2ccc(O[C@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C3)c(C(N)=O)n2)cn1 CHEMBL4203637 IC50 500.0 nM
COc1ccc(-c2cnn3c(N)c(-c4nccs4)c(OC4CCN(C)CC4)nc23)cc1OC CHEMBL4636995 IC50 500.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4nc(N)nc(N)c34)cc2)c1 CHEMBL1973145 pKi 501.19 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 501.19 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 501.19 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 501.19 nM
CN(C)c1ccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)cc1 CHEMBL1984367 pKi 501.19 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 501.19 nM
O=C1Nc2ccccc2C1=Cc1c[nH]c2ccccc12 CHEMBL1986590 pKi 501.19 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 501.19 nM
COc1cc(N2CCN(C)CC2)ccc1C(=O)Nc1n[nH]c2ccc(Cc3cc(F)cc(F)c3)cc12 CHEMBL1973961 pKi 501.19 nM
COCCOCC#Cc1cc(-c2n[nH]c3c2C(=O)c2cc(CN4CCN(C)CC4)ccc2-3)cs1 CHEMBL387971 pKi 501.19 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccc2nccnc12 CHEMBL2004438 pKi 501.19 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)ccc43)cc2OC)cc1 CHEMBL3673436 IC50 503.0 nM
CCOc1cc(-n2c(=O)[nH]c(=O)n(-c3ccccc3)c2=O)ccc1Oc1ccccc1 CHEMBL4527488 EC50 510.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2C1CCCC1 CHEMBL169390 IC50 510.0 nM
CC1(C)Oc2c(ncnc2Nc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)NC1=O CHEMBL5088274 IC50 516.0 nM
Fc1cc(F)cc(-c2ccc3[nH]nc(/C=C/c4ccccn4)c3c2)c1 CHEMBL4799455 IC50 533.9 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 570.0 nM
Cc1ncc(-c2nc3c(NC(C)C)nc(Nc4cnn(C5CC6(C5)CN(C)C6)c4)nc3cc2F)cn1 CHEMBL5274954 IC50 570.0 nM
O=C(Nc1cc(F)cc(F)c1)c1ccc2[nH]nc(/C=C/c3ccccn3)c2c1 CHEMBL4796985 IC50 597.3 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL255863 Kd 600.0 nM
COCOc1cccc(OCOC)c1-c1ccc(NS(C)(=O)=O)cc1C(=O)OC CHEMBL2004025 pKi 630.96 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)cc1C CHEMBL184847 pKi 630.96 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 630.96 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 630.96 nM
O=C1Nc2ccccc2C1=Cc1ccc[nH]1 CHEMBL1996176 pKi 630.96 nM
COc1cc(Nc2ncnc(N3CCCc4cc(C)ccc43)n2)cc(OC)c1OC CHEMBL1992125 pKi 630.96 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(F)ccc21 CHEMBL1993335 pKi 630.96 nM
COc1ccc2c(c1)c(-c1cc3nc(Br)cnc3[nH]1)cn2C CHEMBL2005478 pKi 630.96 nM
CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1995211 pKi 630.96 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 630.96 nM
COc1cncc(C=Cc2ccncc2)c1 CHEMBL1972568 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 630.96 nM
O=C(Cc1ccc(-c2cccnc2)cc1)Nc1ccc(SC(F)F)cc1 CHEMBL1992581 pKi 630.96 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 630.96 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 630.96 nM
Cc1n[nH]c2sc(C(=O)NCCc3ccc(Cl)cc3)cc12 CHEMBL1998414 pKi 630.96 nM
COc1c(C#Cc2cnc3cnccn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4438225 IC50 692.5 nM
CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(Cl)cc2Cl)n(-c2ccccc2)n1 CHEMBL3891994 IC50 700.0 nM
CC(=O)NCc1ncc(NC(=O)c2ccc(C(F)(F)F)c(-c3cn(C)cn3)c2)c(-c2ccccc2)n1 CHEMBL5424164 IC50 760.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](N(C)c3cncnc3)C4)cc(C(F)(F)F)c2)cn1 CHEMBL4437631 IC50 790.0 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(C#N)ccc21 CHEMBL1978562 pKi 794.33 nM
COc1ccc(C(=O)N2c3ccccc3Sc3c(Cl)cncc32)cc1 CHEMBL1988537 pKi 794.33 nM
Cc1cc(Nc2nc(Cl)cc(NCc3ccccc3)n2)n[nH]1 CHEMBL2005449 pKi 794.33 nM
Nc1ncnc2sc(Br)c(-c3ccc(NC(=O)Cc4cccc(Cl)c4)cc3)c12 CHEMBL1980896 pKi 794.33 nM
COc1ccc(C(=O)Nc2nc3ccc(Cl)cc3s2)c(OC)c1 CHEMBL1983309 pKi 794.33 nM
O=c1[nH]cnc2c1sc1c(Cl)ccc(Cl)c12 CHEMBL583144 pKi 794.33 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 794.33 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3[nH]2)cc1 CHEMBL1979057 pKi 794.33 nM
CN1CCN(c2ccc(-c3cnc4c(c3)N(Cc3cc(Cl)ccc3C(F)(F)F)CCN4)cn2)CC1 CHEMBL1164180 pKi 794.33 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 794.33 nM
O=C(Nc1ccc(-c2cccc3sncc23)cc1)Nc1ccc(F)c(C(F)(F)F)c1 CHEMBL2000801 pKi 794.33 nM
CCN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL2004637 pKi 794.33 nM
O=C(c1cccc(-c2cnc3[nH]ccc3c2)c1)N1CCOCC1 CHEMBL1997872 pKi 794.33 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CO)C1 CHEMBL4858720 IC50 920.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 930.0 nM
CC1(C)Oc2c(ncnc2Nc2cccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccccc3)c2)NC1=O CHEMBL5087749 IC50 931.0 nM
Cc1ccc(C#Cc2cnc3cnccn23)cc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(F)(F)F)c1 CHEMBL4440122 IC50 934.9 nM
N#Cc1ccc(-c2cnc3ccc(N4CCC[C@H]4c4cccc(F)c4)nn23)cc1 CHEMBL3582437 IC50 980.0 nM
Cc1ccc(C2(c3ccc(C)cc3)CC2C(=O)Nc2ccncc2)cc1 CHEMBL2003500 pKi 1000.0 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 pKi 1000.0 nM
O=C(Nc1ccccc1N1CCCC1)c1ccc2ccccc2n1 CHEMBL2002799 pKi 1000.0 nM
O=C(Cc1cccs1)Nc1nc2ccccc2s1 CHEMBL1421720 pKi 1000.0 nM
NC(=O)c1cc(-c2cccc(N)c2)cc2cccnc12 CHEMBL1970314 pKi 1000.0 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 1000.0 nM
COc1ccc2[nH]cc(C=C3C(=O)Nc4ccccc43)c2c1 CHEMBL1997275 pKi 1000.0 nM
CN(Cc1cc(Cl)c(O)c2ncccc12)C1CCCCC1 CHEMBL1982413 pKi 1000.0 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 1000.0 nM
Nc1ncnc2c1c(I)nn2C1CCC(O)CC1 CHEMBL1996791 pKi 1000.0 nM
CCN(CC)CCNC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1970290 pKi 1000.0 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 1000.0 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2coc3ncnc(N)c23)cc1 CHEMBL1984586 pKi 1000.0 nM
Nc1ncnc2c1c(I)nn2C1OC(CO)C(O)C1O CHEMBL2001288 pKi 1000.0 nM
N#CC1=C(c2ccccc2)CC(c2ccc(Cl)cc2)C(C(=O)c2ccccc2)C1=O CHEMBL1978371 pKi 1000.0 nM
Oc1ccc(Nc2[nH]nc(-c3ccc(O)cc3)c2-c2ccc(O)cc2)cc1 CHEMBL1969042 pKi 1000.0 nM
Nc1nccn2c(C3CC(CN4CCCC4)C3)nc(-c3cccc(OCc4ccccc4)c3)c12 CHEMBL1991138 pKi 1000.0 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 1000.0 nM
Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1 CHEMBL1968606 pKi 1000.0 nM
O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c(=O)n1-c1ccccc1 CHEMBL4465865 EC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM