CC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 CHEMBL4436749 Ki 0.0017 nM
Cc1cccc(-c2nc(NC(=O)C3CC3)cc3c2CCCN3)c1C CHEMBL4570266 IC50 0.06 nM
CNC(=O)c1cnc2cc(OC)c(OCN3CCN(C)CC3)cc2c1Nc1ccccc1 CHEMBL4778773 IC50 0.08 nM
O=C(NC1COC1)c1cc2c(N3CCCC3c3cccnc3)ccnc2[nH]1 CHEMBL4083992 IC50 0.1 nM
CCNC(=O)c1cc2c(N3CCOCC3C3CC3)ccnc2[nH]1 CHEMBL4070624 IC50 0.1 nM
Cc1cccc(-c2nc(NC(=O)C(F)F)cc3c2CCCN3)c1C CHEMBL4460228 IC50 0.11 nM
COC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 CHEMBL4435945 IC50 0.15 nM
CCC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 CHEMBL4529335 IC50 0.17 nM
Cc1cnc(N)nc1OCC(C)(C)C CHEMBL3781661 IC50 0.2 nM
Cc1cnc(N)nc1N(C)CC(C)(C)C CHEMBL3780962 IC50 0.2 nM
CNC(=O)c1cnc2cc(OC)c(OC)cc2c1Nc1ccccc1 CHEMBL3792684 Kd 0.2 nM
CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCCCCCO2 CHEMBL4747532 Kd 0.2 nM
CNc1cc(NC(C)=O)nc(-c2cccc(C)c2C)c1 CHEMBL4460446 IC50 0.33 nM
CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCCOCCO2 CHEMBL3794167 Kd 0.4 nM
CNc1cc(N(C)[C@@H](C)c2ccccc2)nc(N)n1 CHEMBL4435983 IC50 0.49 nM
Cc1cnc(N)nc1N(C)CC(C)(C)CO CHEMBL3780596 IC50 0.5 nM
Cc1cnc(N)nc1NCC(C)(C)C CHEMBL3780613 IC50 0.5 nM
CNC(=O)c1cnc2cc(OC)c(OC)cc2c1Nc1ccc(Cl)cc1F CHEMBL4783492 Kd 0.5 nM
CNC(=O)c1cnc2cc(OC)c(OC)cc2c1Nc1ccccc1CCS(C)(=O)=O CHEMBL4776026 IC50 0.5 nM
Cc1cnc(N)nc1OCC(C)(C)CO CHEMBL3780032 IC50 0.6 nM
Cc1cccc(-c2nc(NC(=O)C(C)C)cc3c2CCCN3)c1C CHEMBL4577002 IC50 0.61 nM
CNc1cc(O[C@@H](C)c2ccccc2)nc(N)n1 CHEMBL4537820 IC50 0.7 nM
CNc1cc(-c2cccc(Cl)c2Cl)nc(N)n1 CHEMBL3781316 IC50 0.8 nM
CCNC(=O)c1cc2c(N3CCOC[C@@H]3C)ccnc2[nH]1 CHEMBL4096813 IC50 0.8 nM
CNc1cc(N2CCCCC2)nc(N)n1 CHEMBL4565830 IC50 0.8 nM
CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCCCCO2 CHEMBL4784602 IC50 0.8 nM
CNc1cc(N2CCc3ccccc3C2)nc(N)n1 CHEMBL4534555 IC50 0.82 nM
c1ccc(C2CCCN2c2ccnc3[nH]ncc23)cc1 CHEMBL4072758 IC50 1.0 nM
CNc1cc(N2CCCc3ccccc32)nc(N)n1 CHEMBL4464305 IC50 1.1 nM
CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCC(=O)NCCO2 CHEMBL4754128 IC50 1.4 nM
Cc1cnc(N)nc1CCC(C)(C)C CHEMBL3780321 IC50 1.8 nM
CCNC(=O)c1cc2c(N3CCCC3c3ccccc3)ccnc2[nH]1 CHEMBL4091768 pEC50 1.995 nM
O=C(NC1CC1)c1cc2c(N3CCCC3c3ccccn3)ccnc2[nH]1 CHEMBL4073623 pEC50 1.995 nM
c1ccc(C2COCCN2c2ccnc3[nH]ncc23)cc1 CHEMBL4094381 IC50 2.0 nM
CNC(=O)c1cnc2ccccc2c1Nc1ccc(Cl)cc1F CHEMBL4749068 IC50 2.0 nM
CN(C)CCc1ccc(-c2nc(N)nc3ccccc23)cc1 CHEMBL4799076 Kd 3.0 nM
Nc1nc(NC2CC2)cc(-c2cccc(Cl)c2Cl)n1 CHEMBL3782004 IC50 3.0 nM
Cc1cnc(N)nc1NCC(C)(C)CO CHEMBL3781917 IC50 3.1 nM
CNc1cc(N2CCCC2)nc(N)n1 CHEMBL4437933 IC50 3.7 nM
Cc1cc(-c2cccc(Cl)c2Cl)n2nc(N)nc2c1 CHEMBL4439723 IC50 4.1 nM
CC(C)(CO)COc1nc(N)nc2c1CCC2 CHEMBL3781015 IC50 4.5 nM
c1ccc(C2CCCN2c2ccnc3[nH]ccc23)cc1 CHEMBL4061204 IC50 5.0 nM
COC(C)(C)C1CCCN1c1ccnc2[nH]ncc12 CHEMBL4089106 IC50 5.0 nM
CNc1cc(N[C@@H](C)c2ccccc2)nc(N)n1 CHEMBL4444960 IC50 5.6 nM
Nc1nc(NC2CC2)cc(N2CCCCC2)n1 CHEMBL5419782 IC50 6.0 nM
CNc1cc(Oc2ccccc2)nc(N)n1 CHEMBL4476519 IC50 6.8 nM
CNc1cc(-c2cccc(C)c2C)nc(N)n1 CHEMBL4470452 IC50 7.2 nM
CN(C)C(=O)Cc1ccc(-c2nc(N)nc3ccccc23)cc1 CHEMBL3794132 IC50 9.0 nM
CNC(=O)c1cnccc1Nc1ccc(Cl)cc1F CHEMBL4758926 IC50 9.0 nM
COc1cnc(N)nc1OCC(C)(C)CO CHEMBL3780307 IC50 10.0 nM
O=C(NC1CC1)c1cc2c(-c3cccc(Cl)c3)ccnc2[nH]1 CHEMBL4095468 IC50 10.0 nM
O=C(NC1COC1)c1cc2c(N3CCCC3c3ccccn3)ccnc2[nH]1 CHEMBL4094252 pEC50 10.0 nM
CNC(=O)c1cc2c(-c3cccc(Cl)c3)ccnc2[nH]1 CHEMBL4079884 IC50 12.0 nM
CNc1cc(NC2CCCCC2)nc(N)n1 CHEMBL4587534 IC50 12.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)cc3F)c2cc1OC CHEMBL479845 IC50 12.5 nM
Nc1nc2cccc(-c3cccc(Cl)c3Cl)n2n1 CHEMBL4570428 IC50 13.0 nM
COc1cc(-c2cccc(Cl)c2Cl)c2nc(N)[nH]c2c1 CHEMBL4445709 IC50 13.0 nM
Nc1nc2c(-c3cccc(Cl)c3Cl)cccc2[nH]1 CHEMBL4565569 IC50 15.0 nM
CNc1cc(Oc2cccc(C)c2C)nc(N)n1 CHEMBL4574443 IC50 16.0 nM
CCNC(=O)c1cc2c(-c3cccc(Cl)c3)ccnc2[nH]1 CHEMBL4104130 IC50 20.0 nM
Cc1cc(-c2cccc(Cl)c2Cl)c2nc(N)[nH]c2c1 CHEMBL4568781 IC50 20.0 nM
Nc1nc(-c2ccccc2)c2ccccc2n1 CHEMBL4791612 IC50 21.0 nM
CC(C)(CO)COc1nc(N)ncc1Cl CHEMBL3781296 IC50 22.0 nM
CNc1cc(OCc2ccccc2)nc(N)n1 CHEMBL4458818 IC50 26.0 nM
c1cncc(C2CCCN2c2ccnc3[nH]ncc23)c1 CHEMBL4066892 IC50 30.0 nM
Nc1nc2c(-c3ccncc3F)ccnc2[nH]1 CHEMBL4561244 IC50 30.0 nM
C[C@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825141 Kd 39.0 nM
c1ccc2c(c1)OCCN2c1ccnc2[nH]ccc12 CHEMBL4093037 IC50 40.0 nM
CNc1cc(Nc2cccc(C)c2C)nc(N)n1 CHEMBL4578510 IC50 40.0 nM
Cc1cccc(-c2cccc3nc(N)nn23)c1C CHEMBL4447886 IC50 40.0 nM
CNc1cc(N(C)C)nc(N)n1 CHEMBL4532517 IC50 51.0 nM
COc1c(O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)CCC(C)(C)O4 CHEMBL464119 IC50 52.0 nM
CC(C)(C)COc1ccnc(N)n1 CHEMBL3781387 IC50 53.0 nM
CC(=N)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 CHEMBL4439595 IC50 62.0 nM
CC(=O)Nc1cc2ncccc2c(-c2cccc(C)c2C)n1 CHEMBL4463391 IC50 81.0 nM
CC(C)(C)CNc1ccnc(N)n1 CHEMBL3781861 IC50 84.0 nM
CC1(C)CC2CC(C)(CN2c2ncnc3[nH]cnc23)C1 CHEMBL3883604 IC50 100.0 nM
Nc1nc(NCCc2ccccc2)c2nc[nH]c2n1 CHEMBL1709874 IC50 100.0 nM
Cc1cc(OCC(C)(C)C)nc(N)n1 CHEMBL3781493 IC50 112.0 nM
COCC(C)(C)CNc1ccnc(N)n1 CHEMBL3781662 IC50 120.0 nM
Cc1cc(-c2ccccc2)c2oc(N)nc2c1 CHEMBL4083139 IC50 120.0 nM
CNc1cc(-c2cccc(Cl)c2Cl)nc(NC(C)=O)n1 CHEMBL4540488 IC50 125.0 nM
CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCCN(C)C(=O)CO2 CHEMBL4743321 IC50 140.0 nM
CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCCNC(=O)CO2 CHEMBL4791011 IC50 153.0 nM
Nc1nc(SCCc2ccccc2)c2nc[nH]c2n1 CHEMBL1437990 IC50 170.0 nM
c1ccc2c(c1)CCN(c1ccnc3[nH]ccc13)C2 CHEMBL4083073 IC50 200.0 nM
CNC(=O)c1cc2c(-c3cccnc3)ccnc2[nH]1 CHEMBL4091375 IC50 200.0 nM
Nc1nc2c(N)ccc(-c3cccc(Cl)c3Cl)n2n1 CHEMBL4475123 IC50 207.0 nM
c1cnc2c(c1)CCN2c1ccnc2[nH]ccc12 CHEMBL4072600 IC50 300.0 nM
Cc1cc(OCC(C)(C)CO)nc(N)n1 CHEMBL3780652 IC50 302.0 nM
CC(C)(CO)CNc1ccnc(N)n1 CHEMBL3781282 IC50 332.0 nM
OCc1csc(-c2ccnc3[nH]ccc23)n1 CHEMBL4446950 IC50 400.0 nM
COc1ccc2nc3[nH]nc(C)c3c(NCCOCCO)c2c1 CHEMBL3793901 IC50 410.0 nM
CNc1nc(OCCOC)nc2c1[nH]c(=O)n2Cc1ccccc1 CHEMBL4763327 Kd 440.0 nM
Nc1nc2c(-c3cccc(Cl)c3Cl)cccn2n1 CHEMBL4442962 IC50 467.0 nM
COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C CHEMBL323197 IC50 470.0 nM
CC(C)Cn1cnc2c(N)nc3ccccc3c21 CHEMBL1282 IC50 646.0 nM
c1ccc(C2CN(c3ccnc4[nH]ccc34)CCO2)cc1 CHEMBL4065153 IC50 700.0 nM
Cc1cccc(-c2nc(NS(C)(=O)=O)cc3c2CCCN3)c1C CHEMBL4575540 IC50 773.0 nM
Fc1cnccc1-c1ccnc2[nH]ccc12 CHEMBL4541864 IC50 800.0 nM
Nc1nccc(OCC2(CO)CC2)n1 CHEMBL3780535 IC50 850.0 nM
CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCC(=O)N(C)CCO2 CHEMBL4747421 IC50 888.0 nM
Nc1nc2cccc(-c3ccccc3)n2n1 CHEMBL4452041 IC50 936.0 nM
Cc1cc(N2CCCCC2)n2nc(N)nc2c1 CHEMBL4531128 IC50 946.0 nM
COc1cc2ncc(C(=O)N(C)C)c(Nc3ccc(Cl)cc3F)c2cc1OC CHEMBL4749745 EC50 950.0 nM
Cc1cccc(-c2nc(N)cc3c2CCCN3)c1C CHEMBL4593996 IC50 952.0 nM