Cc1ccc2c(=O)n([C@H](C)CN)ccc2c1NC(=O)Cc1ccc(C(F)(F)F)c(F)c1 CHEMBL2324343 IC50 0.01 nM
CC(C)C(CO)n1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2c1=O CHEMBL550030 pIC50 0.05012 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CCCNCCCO)ccc1Cl CHEMBL3415305 IC50 0.06 nM
C[C@@H](C(N)=O)n1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)c(Cl)ccc2c1=O CHEMBL560506 pIC50 0.07943 nM
O=C(NCC(CC1(C(F)(F)F)CC1)c1ccc(C(F)(F)F)nc1)c1ccccc1Cl CHEMBL3679059 IC50 0.09 nM
CN(C)c1ccc(C(=O)N2CCC(n3cncc3-c3ccc(OS(=O)(=O)c4cccc5cnccc45)cc3)CC2)cc1 CHEMBL4165149 IC50 0.11 nM
C[C@@H](CO)n1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2c1=O CHEMBL5430904 IC50 0.15 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2c(=O)n(C(CO)CO)ccc12 CHEMBL551360 pIC50 0.1995 nM
C[C@H]1Cn2c(nnc2-c2cscn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663257 IC50 0.2 nM
C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663243 IC50 0.2 nM
O=C(NCC1(c2ccc(F)nc2)CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3679011 IC50 0.28 nM
CC[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663294 IC50 0.3 nM
O=C(NCC(CC1CC1)c1ccc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679036 IC50 0.31 nM
O=C(Cc1cccc(C(F)(F)F)c1F)Nc1c(Cl)ccc2c(=O)n(C3CC3)ccc12 CHEMBL564882 pIC50 0.3162 nM
CS(=O)(=O)c1ccc(C(=O)N2CCC(n3cncc3-c3ccc(OS(=O)(=O)c4cccc5cnccc45)cc3)CC2)cc1 CHEMBL4521847 IC50 0.32 nM
O=C(NCC(c1ccc(F)cc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3984958 IC50 0.33 nM
Cc1ccc2c(=O)n([C@H](C)CO)ccc2c1NC(=O)Cc1ccc(C(F)(F)F)c(F)c1 CHEMBL551362 pIC50 0.3981 nM
C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663316 IC50 0.4 nM
CN(C)c1ccc(C(=O)N2CCC(n3cncc3-c3ccc(OS(=O)(=O)c4cccc(C(=O)NC5CC5)c4)cc3)CC2)cc1 CHEMBL4582650 IC50 0.49 nM
Cc1cc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)nn1C[C@@H](O)CN CHEMBL1824026 IC50 0.5 nM
C[C@H]1Cn2c(nnc2-c2ccccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663244 IC50 0.5 nM
Cc1cccc(C(=O)NC[C@H](c2ccc(Cl)cc2)N2CCOCC2)c1Cl CHEMBL3955749 IC50 0.53 nM
Cc1cccc(C(=O)NCC2(c3ccc(C(F)(F)F)nc3)CCC(F)(F)CC2)c1Cl CHEMBL3679043 IC50 0.54 nM
C[C@H]1Cn2c(nnc2-c2cc[nH]n2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663253 IC50 0.6 nM
COc1ccc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCC(F)(F)CC2)cc1 CHEMBL3913134 IC50 0.6 nM
O=C(NCC(c1ccc(Cl)cc1)N1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3916032 IC50 0.6 nM
O=C(NC[C@H](c1ccc(Cl)cc1)N1CCOCC1)c1cccc(Cl)c1Cl CHEMBL4109892 IC50 0.62 nM
O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(F)cccc1Cl CHEMBL3958103 IC50 0.62 nM
CN1C[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2Cl)N(C)C1=O CHEMBL1271548 pIC50 0.631 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3913344 IC50 0.65 nM
C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663242 IC50 0.7 nM
C[C@H]1Cn2c(nnc2-c2cc(CO)ccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663260 IC50 0.7 nM
C[C@H]1Cn2c(nnc2-c2ccc(F)cn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663255 IC50 0.7 nM
Cc1c(Br)cccc1C(=O)NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1 CHEMBL3679042 IC50 0.71 nM
O=C(NCC(CC1CC1)c1ccc(C(F)(F)F)nc1)c1c(Cl)cccc1Cl CHEMBL3679084 IC50 0.71 nM
Cc1ccc(Cl)c(C(=O)NCC2(c3ccc(F)nc3)CCC(F)(F)CC2)c1 CHEMBL3639778 IC50 0.76 nM
O=C(NCC(CC1(C(F)F)CC1)c1ccc(C2CC2)nc1)c1cccc(Cl)c1Cl CHEMBL3679051 IC50 0.76 nM
COC[C@H](O)Cn1c(=O)cnn(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)c1=O CHEMBL1823817 IC50 0.76 nM
CCN1C(=O)N(C)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218174 pIC50 0.7943 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)[C@@H]1CN(C)C(=O)N1C CHEMBL2218383 pIC50 0.7943 nM
CN1C[C@@H](C(=O)NCc2c(Cl)cc(Cl)cc2Cl)N(C)C1=O CHEMBL2218569 pIC50 0.7943 nM
O=C1c2nnc(-c3cnccn3)n2C[C@H](C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663286 IC50 0.8 nM
O=C(NCC(CC1CC1)c1cnc(C(F)(F)F)nc1)c1c(Cl)cccc1Cl CHEMBL3679094 IC50 0.82 nM
COc1ccc(Cl)c(C(=O)NCC2(c3ccc(F)nc3)CCC(F)(F)CC2)c1 CHEMBL3679022 IC50 0.83 nM
O=C(NCC(CC1CC1)c1cnc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679063 IC50 0.86 nM
O=C(NCC(c1ccc(F)nc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3979867 IC50 0.89 nM
O=C(NCC1(c2cnc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3679104 IC50 0.95 nM
COc1ccc(C2(CNC(=O)c3cccc(Cl)c3Cl)CCC(F)(F)CC2)cn1 CHEMBL3679029 IC50 0.96 nM
CC(C)(C)OC(=O)N1CCN(C(=O)C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)NS(=O)(=O)c2cccc3cnccc23)CC1 CHEMBL338578 IC50 1.0 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2c(=O)n(C[C@H]3CCCN3)ccc12 CHEMBL556680 pIC50 1.0 nM
CN1C[C@@H](C(=O)NCc2ccc(F)c(C(F)(F)F)c2Cl)N(C)C1=O CHEMBL2218379 pIC50 1.0 nM
O=C(c1cccc(Cl)c1Cl)N1CCn2c(nnc2-c2cscn2)C1 CHEMBL2218129 pIC50 1.0 nM
O=C1c2nnc(-c3ncccn3)n2C[C@H](C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663289 IC50 1.0 nM
C[C@H]1Cn2c(nnc2-c2ncc(F)cn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663259 IC50 1.0 nM
C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(Cl)c1Cl CHEMBL3663239 IC50 1.0 nM
C[C@H]1Cn2c(nnc2-c2cccnc2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663254 IC50 1.0 nM
Cc1ccc(C(CNC(=O)c2cccc(Cl)c2Cl)CC(C)C)cn1 CHEMBL3679005 IC50 1.0 nM
C[C@H]1Cc2c(nnn2-c2ncc(F)cn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3955645 IC50 1.0 nM
C[C@H]1Cc2c(nnn2-c2ncccn2)CN1C(=O)c1ccnc(C(F)(F)F)c1[18F] CHEMBL5186767 IC50 1.0 nM
C[C@H](CO)n1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2c1=O CHEMBL5429737 IC50 1.0 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@@H]2CCC[C@H]1c1nnc(-c3ncc(F)cn3)n1C2 CHEMBL3697521 IC50 1.1 nM
O=C1c2nnc(-c3cc[nH]n3)n2CC(C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663291 IC50 1.1 nM
O=C(NCC(c1ccc(F)cc1)c1cnc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679134 IC50 1.1 nM
C[C@H]1Cc2c(nnn2-c2ncccn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3891612 IC50 1.1 nM
Cc1cc(-c2nnc3n2C[C@H](C)N(Cc2cccc(C(F)(F)F)c2Cl)C3=O)n[nH]1 CHEMBL3663252 IC50 1.2 nM
C[C@H]1Cn2c(nnc2-c2nccs2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663256 IC50 1.2 nM
O=C(NCC1(c2ccc(F)nc2)CCC(F)(F)CC1)c1cc(C(F)(F)F)ccc1Cl CHEMBL3679013 IC50 1.2 nM
O=C(NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3679026 IC50 1.2 nM
O=C(NCC1(c2cncc(F)c2)CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3679035 IC50 1.2 nM
C[C@H](CO)n1ccc2c(NC(=O)Cc3ccc(Cl)c(C(F)(F)F)c3)cccc2c1=O CHEMBL550436 pIC50 1.259 nM
CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(c2ccc(F)cc2)CC1)S(=O)(=O)c1cccc2cnccc12 CHEMBL434773 pIC50 1.259 nM
O=C(NCc1cccc(C(F)(F)F)c1Cl)C1CCC(=O)N1C1CC1 CHEMBL2218258 pIC50 1.259 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)[C@@H]1CCC(=O)N1C CHEMBL2218261 pIC50 1.259 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)[C@@H]1CNC(=O)N1C CHEMBL2218369 pIC50 1.259 nM
Cc1c(CNC(=O)[C@@H]2CN(C)C(=O)N2C)cccc1C(F)(F)F CHEMBL2218390 pIC50 1.259 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(-c3cscn3)cnc2C1 CHEMBL2218340 pIC50 1.259 nM
O=C(NNc1c(Cl)cncc1Cl)C1C2CC3CC(C2)C(Br)C1C3 CHEMBL2048437 IC50 1.3 nM
O=C(NCC1(c2ccc(C3CC3)nc2)CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3679028 IC50 1.3 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2ncccc21 CHEMBL3959728 IC50 1.3 nM
O=C(NC1CCc2cc(Cl)cc(Cl)c21)C1COc2ncccc21 CHEMBL3965931 IC50 1.3 nM
O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3907209 IC50 1.3 nM
C[C@@H]1Cc2c(nnn2-c2ccccn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4113200 IC50 1.3 nM
CN(C)c1ccc(C(=O)N2CCN(c3cc(=O)[nH]c(=O)n3Cc3ccc(OS(=O)(=O)c4cccc5cnccc45)cc3)CC2)cc1 CHEMBL4561852 IC50 1.33 nM
C[C@@H]1c2nnc(-c3ccccn3)n2CCN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604331 IC50 1.4 nM
C[C@H]1Cn2c(nnc2-c2cocn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663247 Ki 1.4 nM
O=C1c2nnc(-c3ncccn3)n2CC(C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663287 IC50 1.4 nM
CC[C@H]1Cn2c(nnc2-c2cccnc2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663295 IC50 1.4 nM
O=C(NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1cccc(F)c1Cl CHEMBL3679078 IC50 1.4 nM
COc1cccc(C(=O)NCC(CC2CC2)c2cnc(C(F)(F)F)nc2)c1C CHEMBL3679098 IC50 1.4 nM
O=C(c1ccc([N+](=O)[O-])cc1)N1CCC(n2cncc2-c2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)CC1 CHEMBL4584526 IC50 1.49 nM
CC[C@H]1Cn2c(nnc2-c2cc[nH]n2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663296 IC50 1.5 nM
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)CC2(C(F)(F)F)CC2)cn1 CHEMBL3679048 IC50 1.5 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCc2ncsc21 CHEMBL3933536 IC50 1.5 nM
CCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc21 CHEMBL3949978 IC50 1.5 nM
COc1cccc(C(=O)NCC(c2ccc(Cl)cc2)N2CCOCC2)c1Cl CHEMBL3918405 IC50 1.5 nM
O=C(NCC1C2CC3CC(C2)CC1C3)c1cc(CCCNCCCO)ccc1Cl CHEMBL4171354 IC50 1.5 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cccc(Cl)c1Cl CHEMBL441479 pA2 1.585 nM
COc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 CHEMBL340983 pA2 1.585 nM
CCN1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1222821 pIC50 1.585 nM
CN1C(=O)CC[C@H]1C(=O)NCc1cccc2ccccc12 CHEMBL2218262 pIC50 1.585 nM
CN1CC(C(=O)NCc2cccc(C(F)(F)F)c2Cl)N(C)C1=O CHEMBL2218265 pIC50 1.585 nM
Cc1cccc(C)c1N1CCN(Cc2ccc(Cl)cc2Cl)C(=O)C1=O CHEMBL2218090 pIC50 1.585 nM
CCN1C(=O)N(C)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218173 pIC50 1.585 nM
CN1C(=O)N(c2cccnc2Cl)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218366 pIC50 1.585 nM
CN1C(=O)NC[C@H]1C(=O)NCc1c(Cl)cc(Cl)cc1Cl CHEMBL2218570 pIC50 1.585 nM
O=C(c1cccc(Cl)c1Cl)N1CCn2c(nnc2-c2cnccn2)C1 CHEMBL2218113 pIC50 1.585 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2ccc[nH]2)C1 CHEMBL2218118 pIC50 1.585 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2cscn2)C1 CHEMBL2218119 pIC50 1.585 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2ccco2)C1 CHEMBL2218132 pIC50 1.585 nM
O=C(c1ccc(F)c(Cl)c1Cl)N1CCn2c(nnc2-c2ccc(F)cn2)C1 CHEMBL2218240 pIC50 1.585 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(-c3nccs3)cnc2C1 CHEMBL2218331 pIC50 1.585 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(-c3ncccn3)cnc2C1 CHEMBL2218339 pIC50 1.585 nM
Cc1c(CN2C(=O)c3nnc(-c4cnccn4)n3C[C@@H]2C)cccc1C(F)(F)F CHEMBL3663305 IC50 1.6 nM
COc1cccc(C(=O)NCC2(c3ccc(C(F)(F)F)nc3)CCC(F)(F)CC2)c1C CHEMBL3679039 IC50 1.6 nM
O=C(NCC(CC1(C(F)F)CC1)c1ccc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679053 IC50 1.6 nM
O=C(NCC(c1ccc(Cl)cc1)C1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3679090 IC50 1.6 nM
O=C(NCC(CC1(C(F)(F)F)CC1)c1cnc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679115 IC50 1.6 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2ncsc21 CHEMBL3931251 IC50 1.6 nM
Cc1nc2c(c(-c3ccn[nH]3)n1)CC(C)N(C(=O)c1ccc(Cl)cc1Cl)C2 CHEMBL3674102 IC50 1.7 nM
C[C@H]1Cn2c(nnc2-c2nccc(C(F)(F)F)n2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663277 IC50 1.7 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@H]2CC[C@@H]1c1nnc(-c3ccsc3)n1C2 CHEMBL3697548 IC50 1.7 nM
O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1cccc(F)c1Cl CHEMBL3918703 IC50 1.7 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1cccc(F)c1Cl CHEMBL3914424 IC50 1.7 nM
C[C@H]1Cc2c(nnn2-c2ncc(F)cn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3904992 IC50 1.7 nM
C[C@H]1Cc2c(nnn2-c2ccccn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3931075 IC50 1.7 nM
CNC(=O)c1cccc(S(=O)(=O)Oc2ccc(-c3cncn3C3CCN(C(=O)c4ccc(Cl)c(C(F)(F)F)c4)CC3)cc2)c1 CHEMBL4560935 IC50 1.76 nM
CC1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(Cl)c1Cl CHEMBL3663237 IC50 1.8 nM
O=C(NCC(c1ccc(F)cc1)c1cnc(C(F)(F)F)nc1)c1cccc(F)c1Cl CHEMBL3679139 IC50 1.8 nM
O=C(NC1CCc2cc(Cl)cc(Cl)c21)C1CCOc2ncsc21 CHEMBL3977105 IC50 1.8 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc21 CHEMBL3923911 IC50 1.8 nM
O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1ccccc1Cl CHEMBL3955304 IC50 1.8 nM
CCn1ccc(-n2nnc3c2C[C@H](C)N(C(=O)c2cccc(C(F)(F)F)c2Cl)C3)n1 CHEMBL4077411 IC50 1.8 nM
Cc1c(Cl)cccc1Nc1nc(=O)cc2n1C(c1ccccc1)COC2 CHEMBL5429417 IC50 1.8 nM
O=C(NCC(CC1CC1)c1cnc(C(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679149 IC50 1.9 nM
O=C(NC1CC1)c1cccc(Cl)c1Cl CHEMBL3679152 IC50 1.9 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCCc2ncsc21 CHEMBL3914773 IC50 1.9 nM
COc1cccc(C(=O)NCC(c2ccc(C(F)F)nc2)N2CCC(F)(F)CC2)c1Cl CHEMBL3929462 IC50 1.9 nM
CN1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1I CHEMBL4541082 Ki 1.9 nM
O=C(Cc1ccc(Cl)c(C(F)(F)F)c1)Nc1cccc2c(=O)n(CCO)ccc12 CHEMBL560219 pIC50 1.995 nM
CN1C[C@@H](C(=O)NCc2ccc(Cl)cc2Cl)N(C)C1=O CHEMBL1269248 pIC50 1.995 nM
CC(C)N1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218292 pIC50 1.995 nM
O=C(NCc1cccc(C(F)(F)F)c1Cl)[C@@H]1CCC(=O)N1C1CCC1 CHEMBL2218313 pIC50 1.995 nM
Cc1c(CNC(=O)[C@@H]2CNC(=O)N2C)cccc1C(F)(F)F CHEMBL2218363 pIC50 1.995 nM
CN1C(=O)N(c2ncccc2F)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218558 pIC50 1.995 nM
CN1C(=O)N(CC(F)(F)F)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218563 pIC50 1.995 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2cnccn2)C1 CHEMBL2218122 pIC50 1.995 nM
O=C(c1ccc(Cl)cc1Cl)N1CCn2c(nnc2-c2cscn2)C1 CHEMBL2218140 pIC50 1.995 nM
O=C(c1ccc(F)c(Cl)c1Cl)N1CCn2c(nnc2-c2cnccn2)C1 CHEMBL2218230 pIC50 1.995 nM
O=C(c1ccc(Cl)c(F)c1Cl)N1CCn2c(nnc2-c2cnccn2)C1 CHEMBL2218231 pIC50 1.995 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(-c3cnccn3)cnc2C1 CHEMBL2218327 pIC50 1.995 nM
C[C@H]1Cn2c(nnc2-c2cncs2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663262 Ki 2.0 nM
O=C(NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1ccccc1Cl CHEMBL3679075 IC50 2.0 nM
O=C(NCC(c1ccc(F)cc1)c1cnc(C(F)(F)F)nc1)c1ccccc1Cl CHEMBL3679135 IC50 2.0 nM
Cc1ccccc1C(=O)NCC(c1ccc(Cl)cc1)N1CCC(F)(F)CC1 CHEMBL3953886 IC50 2.0 nM
O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3919230 IC50 2.0 nM
C[C@H]1c2nnn(-c3ccccn3)c2CCN1C(=O)c1ccc(F)c(Cl)c1Cl CHEMBL3915589 IC50 2.0 nM
C[C@H]1Cc2c(nnn2-c2ncc(F)cn2)CN1C(=O)c1ccc(F)c(Cl)c1Cl CHEMBL3928714 IC50 2.0 nM
N#C/N=C(\NCC12CC3CC(CC(C3)C1)C2)Nc1cccc2ncccc12 CHEMBL4074449 IC50 2.0 nM
C[C@H]1Cc2c(nnn2-c2ccsc2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4072525 IC50 2.0 nM
CC(C)(C)c1ccc(NC(=O)N2CCN(c3c(Nc4cccc5ncccc45)c(=O)c3=O)CC2)cc1 CHEMBL5079389 IC50 2.0 nM
CC1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663240 IC50 2.1 nM
O=C(NCC(CC1CC1)c1ccc(C(F)(F)F)nc1)c1c(F)cccc1Cl CHEMBL3679067 IC50 2.1 nM
C[C@@H]1c2nnn(-c3ncccn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4068397 pIC50 2.188 nM
O=C(NCC(c1ccc(F)cc1)c1ccc(C(F)(F)F)nc1)c1ccccc1Cl CHEMBL3679129 IC50 2.2 nM
Cc1cc(Cl)cc(Cl)c1CC(=O)NC1COc2cnccc21 CHEMBL3954355 IC50 2.2 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1cc(F)cc(Cl)c1Cl CHEMBL3937175 IC50 2.2 nM
COc1ccc(C(=O)NCC(c2cnc(C(F)(F)F)nc2)N2CCC(F)(F)CC2)c(Cl)c1 CHEMBL3906693 IC50 2.2 nM
C[C@@H]1c2nnn(-c3cc[nH]n3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4112493 IC50 2.2 nM
O=C(NCC1(c2ccc(F)nc2)CCC(F)(F)CC1)c1cc(Cl)ccc1Cl CHEMBL3679021 IC50 2.3 nM
O=C(NCC(CC1CC1)c1ccc(C(F)(F)F)nc1)c1ccccc1Cl CHEMBL3679037 IC50 2.3 nM
Cc1c(C(=O)N2CCc3c(nnn3-c3ncccn3)C2)cccc1C(F)(F)F CHEMBL3890699 Ki 2.3 nM
Cc1ccc(Cl)c(C(=O)NCC2(c3ccccc3)CCN(C)CC2)c1 CHEMBL3679001 IC50 2.4 nM
O=C(NCC(CC1(C(F)(F)F)CC1)c1cnc(C(F)(F)F)nc1)c1ccccc1Cl CHEMBL3679110 IC50 2.4 nM
O=C(NCC(c1ccc(C(F)F)nc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3910998 IC50 2.4 nM
C[C@H]1Cc2c(nnn2-c2ncccc2F)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3900021 IC50 2.4 nM
CCc1nnc2n1CCN(C(=O)c1cccc(C(F)(F)F)c1Cl)[C@@H]2c1ccccc1 CHEMBL4471289 IC50 2.4 nM
Cc1ccc(-c2ncco2)cc1Nc1nc(=O)cnn1Cc1cc(F)c(F)c(F)c1 CHEMBL5407113 IC50 2.4 nM
CC[C@H]1Cn2c(nnc2-c2ccc(F)cn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663298 Ki 2.5 nM
C[C@H]1Cn2c(nnc2-c2ccn(C)n2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663249 IC50 2.5 nM
C[C@H]1Cc2c(nnn2-c2ncc(F)cn2)CN1C(=O)c1ccc(Cl)c(F)c1Cl CHEMBL3974795 Ki 2.5 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(-c3cccnc3)n[nH]c2C1 CHEMBL3935995 IC50 2.5 nM
CN1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Br CHEMBL4435339 Ki 2.5 nM
O=C(Cc1ccc(F)c(C(F)(F)F)c1)Nc1cccc2c(=O)n([C@@H]3CNC[C@H]3O)ccc12 CHEMBL552513 pIC50 2.512 nM
Cc1noc(C)c1CC(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1210623 pIC50 2.512 nM
Cc1n[nH]c(C)c1CC(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1210561 pIC50 2.512 nM
CN1C(=O)N(c2cn(C)cn2)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1271885 pIC50 2.512 nM
Cc1n[nH]c(C(F)(F)F)c1CC(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2094247 pIC50 2.512 nM
CCN1C(=O)CCC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218268 pIC50 2.512 nM
CN1C[C@@H](C(=O)NCc2ccc(F)c(Cl)c2Cl)N(C)C1=O CHEMBL2218377 pIC50 2.512 nM
CN1C(=O)N(CC(F)F)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218559 pIC50 2.512 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2ccc(F)cn2)C1 CHEMBL2218121 pIC50 2.512 nM
O=C(c1cccc(Cl)c1Cl)N1CCn2c(nnc2-c2ccc[nH]2)C1 CHEMBL2218128 pIC50 2.512 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nc(Cl)c2Br)C1 CHEMBL2218235 pIC50 2.512 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2ccccc2O)C1 CHEMBL2218338 pIC50 2.512 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@H]2CC[C@@H]1c1nnc(-c3cccs3)n1C2 CHEMBL3697551 IC50 2.6 nM
Cc1ccccc1C(=O)NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1 CHEMBL3679032 IC50 2.6 nM
O=C(NCC(c1ccc(F)cc1)c1cnc(C(F)(F)F)nc1)c1c(F)cccc1Cl CHEMBL3679138 IC50 2.6 nM
O=C(NCc1cccc(C(F)(F)F)c1Cl)C1CCCc2ncsc21 CHEMBL3901255 IC50 2.6 nM
COc1cccc(C(=O)NCC(c2ccc(F)cc2)N2CCC(F)(F)CC2)c1Cl CHEMBL3918929 IC50 2.6 nM
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CC(F)(F)C(F)(F)C2)cn1 CHEMBL3936747 IC50 2.6 nM
CCc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCC(F)(F)CC2)cn1 CHEMBL3890642 IC50 2.6 nM
O=C(NCc1c(Cl)cc(Cl)cc1CO)C1CCCc2ncsc21 CHEMBL3892292 IC50 2.7 nM
O=C(NCc1c(Cl)cc(Cl)cc1CO)C1COc2ncccc21 CHEMBL3937731 IC50 2.7 nM
O=C(NCc1cccc(C(F)(F)F)c1Cl)C1CCOc2ncccc21 CHEMBL3968482 IC50 2.7 nM
Cc1c(C(=O)N2CCc3c(nnn3-c3ncccn3)[C@H]2C)cccc1C(F)(F)F CHEMBL4113724 IC50 2.7 nM
Cc1nnc2n1CCN(C(=O)c1cccc(C(F)(F)F)c1Cl)[C@@H]2c1ccccc1 CHEMBL4442874 IC50 2.7 nM
C[C@@H]1c2ncnc(-c3ccn[nH]3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3674126 IC50 2.8 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1ccccc1Cl CHEMBL3923051 IC50 2.8 nM
Cc1nc2c(c(-c3ccn[nH]3)n1)C[C@@H](C)N(C(=O)c1ccc(Cl)c(F)c1Cl)C2 CHEMBL3674090 IC50 2.9 nM
O=C(NCC(CC1CC1)c1ccc(C(F)(F)F)nc1)c1cccc(F)c1Cl CHEMBL3679072 IC50 2.9 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(nnn2-c2cnccn2)C1 CHEMBL3924464 IC50 2.9 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(nnn2-c2cc(F)ccn2)C1 CHEMBL3926483 IC50 2.9 nM
Cc1c(C(=O)N2CCc3c(nnn3-c3ncccn3)C2C)cccc1C(F)(F)F CHEMBL3922271 IC50 2.9 nM
N#C/N=C(/NCc1ccc([18F])cc1)Nc1cccc2ncccc12 CHEMBL5171821 Ki 2.9 nM
Cc1cc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)n[nH]1 CHEMBL560241 IC50 3.0 nM
Cc1cc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)nn1C[C@H](O)CN CHEMBL1824027 IC50 3.0 nM
O=C(NC1CCc2cc(Cl)cc(Cl)c21)C1CCc2ncsc21 CHEMBL3924115 IC50 3.0 nM
O=C(NCC(c1cnc(C2CC2)nc1)N1CCC(F)(F)CC1)c1ccccc1Cl CHEMBL3893340 IC50 3.0 nM
O=C(c1cccc(Cl)c1Cl)N1CCc2c(nnn2-c2ncccn2)C1 CHEMBL3905914 IC50 3.0 nM
C[C@@H]1c2nnn(-c3ncc(F)cn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4079239 IC50 3.0 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2nc(-c3ccc(CO)cc3)ccc12 CHEMBL4159914 IC50 3.0 nM
[11CH3]N1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL5204842 IC50 3.0 nM
Cc1c(F)cc(CO)cc1Nc1nc(=O)cnn1Cc1cc(F)c(F)c(F)c1 CHEMBL5440534 IC50 3.0 nM
Cc1c(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)cccc1C(F)(F)F CHEMBL3697543 IC50 3.1 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1(F)CCOc2ncccc21 CHEMBL3938838 IC50 3.1 nM
CN1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1222883 Ki 3.1 nM
O=C(OCC1c2ncn(-c3ccccc3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl)c1cccc(C(F)(F)F)c1Cl CHEMBL3967670 IC50 3.1 nM
Cc1cc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)nn1CC(=O)NCCN(C)C CHEMBL560563 pIC50 3.162 nM
O=C(CC1CCCCCC1)Nc1cccc2c(=O)n([C@H]3CCNC3)ccc12 CHEMBL552512 pIC50 3.162 nM
Cc1cnn(C)c1CC(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1210563 pIC50 3.162 nM
O=C(NCc1ccc(Cl)cc1Cl)C1CCC(=O)N1C1CC1 CHEMBL2218201 pIC50 3.162 nM
Cc1c(CNC(=O)[C@@H]2CCC(=O)N2C)cccc1C(F)(F)F CHEMBL2218252 pIC50 3.162 nM
CCN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)c(Cl)c1Cl CHEMBL2218257 pIC50 3.162 nM
CN1C(=O)CCC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218284 pIC50 3.162 nM
Cc1c(CNC(=O)[C@@H]2CCC(=O)N2C2CCC2)cccc1C(F)(F)F CHEMBL2218317 pIC50 3.162 nM
CN1C[C@@H](C(=O)NCc2ccc(F)c(F)c2Cl)N(C)C1=O CHEMBL2218321 pIC50 3.162 nM
CCN1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1C#N CHEMBL2218483 pIC50 3.162 nM
CN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)c(C(F)(F)F)c1Cl CHEMBL2218502 pIC50 3.162 nM
CN1C(=O)N(c2ncccn2)CC1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218452 pIC50 3.162 nM
Cc1cccc(C)c1N1CCN(Cc2ccc(F)cc2Cl)C(=O)C1=O CHEMBL2218730 pIC50 3.162 nM
CN1C(=O)N(CCF)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218564 pIC50 3.162 nM
CCN1C[C@@H](C(=O)NCc2ccc(Cl)cc2Cl)N(C)C1=O CHEMBL2218565 pIC50 3.162 nM
CN1C(=O)N(CC2CC2)CC1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218571 pIC50 3.162 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2ccccc2)C1 CHEMBL2218584 pIC50 3.162 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2ccccn2)C1 CHEMBL2218680 pIC50 3.162 nM
O=C(c1ccc(Cl)cc1Cl)N1CCn2c(nnc2-c2cnccn2)C1 CHEMBL2218136 pIC50 3.162 nM
O=C(c1cccc(Cl)c1Cl)N1CCn2c(nnc2-c2ccc(F)cc2)C1 CHEMBL2218212 pIC50 3.162 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nc(Cl)c2Cl)C1 CHEMBL2218329 pIC50 3.162 nM
C[C@H]1Cn2c(nnc2-c2ccc(F)cn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604427 IC50 3.2 nM
CC[C@H]1Cn2c(nnc2-c2ncc(F)cn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663297 Ki 3.2 nM
C[C@H]1Cn2c(nnc2-c2ncco2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663246 IC50 3.2 nM
Cc1cnc(-c2nnc3n2C[C@H](C)N(Cc2cccc(C(F)(F)F)c2Cl)C3=O)cn1 CHEMBL3663245 Ki 3.2 nM
O=C(NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1cccc(Cl)c1F CHEMBL3679080 IC50 3.2 nM
O=C(NCC(CC1CC1)c1cnc(C(F)(F)F)nc1)c1ccccc1Cl CHEMBL3679087 IC50 3.2 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3892986 IC50 3.2 nM
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCC(F)(F)CC2)cn1 CHEMBL3910153 IC50 3.2 nM
C[C@H]1c2nnn(-c3cnccn3)c2CCN1C(=O)c1ccc(F)c(Cl)c1Cl CHEMBL3925273 Ki 3.2 nM
C[C@H]1Cc2c(nnn2-c2ncccc2F)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3949374 Ki 3.2 nM
CC1Cc2c(nnn2-c2ccccn2)CN1C(=O)c1ccc(F)c(Cl)c1Cl CHEMBL3974838 IC50 3.2 nM
Cc1ccnc(-n2nnc3c2CCN(C(=O)c2cccc(Cl)c2Cl)C3C)c1 CHEMBL3964899 IC50 3.2 nM
O=C(NCC1(c2ccc(Cl)nc2)CCCCC1)c1c(Cl)ccc2[nH]ccc12 CHEMBL4464059 IC50 3.2 nM
Cc1cccc(-c2nnc3n2C[C@H](C)N(Cc2cccc(C(F)(F)F)c2Cl)C3=O)n1 CHEMBL3663270 IC50 3.3 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(nnn2-c2ccccn2)C1 CHEMBL3920897 IC50 3.3 nM
CC1c2nnn(-c3ncc(F)cn3)c2CCN1C(=O)c1cccc(Cl)c1Cl CHEMBL3907793 IC50 3.3 nM
C[C@@H]1c2nnn(-c3ncccn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1F CHEMBL4108013 IC50 3.3 nM
COc1cccc(C(=O)NCC(CC2CC2)c2cnc(C(F)(F)F)nc2)c1Cl CHEMBL3679097 IC50 3.4 nM
O=C(NCC1(c2ccc(Cl)nc2)CCCCC1)C1CCCc2ncsc21 CHEMBL3966261 IC50 3.4 nM
C[C@H]1c2nnn(-c3cnccn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3937843 IC50 3.4 nM
C[C@@H]1Cc2c(nnn2-c2cc(F)ccn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL4112028 IC50 3.4 nM
O=C(NCC1(c2ccc(Cl)nc2)CCCCC1)C1CCCc2[nH]ccc21 CHEMBL4573316 IC50 3.4 nM
C[C@@H]1c2nnn(-c3cnccn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4074304 pIC50 3.467 nM
Cc1cc(Cl)cc(Cl)c1CC(=O)NC1COc2ncccc21 CHEMBL3912518 IC50 3.5 nM
COc1cccc(C(=O)NCC(c2ccc(C(F)(F)F)nc2)N2CCOCC2)c1Cl CHEMBL3920622 IC50 3.5 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)CC1)c1cccc(Cl)c1Cl CHEMBL3916515 IC50 3.5 nM
O=C(NCC(c1cnc(C2CC2)nc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3908920 IC50 3.5 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CCCNCCCO)ccc1Cl CHEMBL3545108 IC50 3.5 nM
Cc1ccccc1N1CCN(C(=O)[C@H](Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)N(C)S(=O)(=O)c2cccc3cnccc23)CC1 CHEMBL28262 Kd 3.57 nM
C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1 CHEMBL3663308 IC50 3.6 nM
Cc1cccc(C(=O)NCC(c2ccc(Cl)cc2)N2CCC(F)(F)CC2)c1C CHEMBL3932041 IC50 3.6 nM
COc1cccc(C(=O)NCC(c2cnc(C(F)(F)F)nc2)N2CCC(F)(F)CC2)c1Cl CHEMBL3904440 IC50 3.6 nM
O=C(c1ccc(F)c(Cl)c1Cl)N1CCc2c(nnn2-c2ccccn2)C1 CHEMBL3921656 IC50 3.6 nM
C[C@@H]1CCC[C@@](O)(CNC(=O)c2c(Cl)ccc3nc(N4CCC(N(C)C)C4)ccc23)C1 CHEMBL4449293 IC50 3.6 nM
O=C(NCC(CC1(F)CC1)c1ccc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679099 IC50 3.7 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1C2CCCC1c1nnc(-c3ncccn3)n1C2 CHEMBL3697509 IC50 3.8 nM
C[C@H]1Cn2c(nnc2-c2ccncn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663258 IC50 3.8 nM
CC1c2nnc(-c3ccccn3)n2CCN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604320 IC50 3.9 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCCCc2ncsc21 CHEMBL3980150 IC50 3.9 nM
O=C(NCC(c1ccc(Cl)nc1)N1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3924667 IC50 3.9 nM
O=C(NCC(c1cnc(C(F)F)nc1)N1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3943782 IC50 3.9 nM
CC1Cc2c(nnn2-c2cc[nH]n2)CN1C(=O)c1cccc(C(F)(F)F)c1F CHEMBL3917725 IC50 3.9 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCOCC1)c1c(Cl)ccc2[nH]ccc12 CHEMBL4515801 IC50 3.9 nM
Nc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 CHEMBL129982 pA2 3.981 nM
CN(C)C[C@H](O)Cc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 CHEMBL564535 pIC50 3.981 nM
CN1C(=O)C(F)(F)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1271767 pIC50 3.981 nM
CN1C(=O)COC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1271769 pIC50 3.981 nM
CN1C(=O)NC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1271604 pIC50 3.981 nM
CN1C(=O)N(c2nccn2C)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL1271884 pIC50 3.981 nM
Cc1c(CNC(=O)[C@@H]2CCC(=O)N2C(C)C)cccc1C(F)(F)F CHEMBL2218293 pIC50 3.981 nM
N#Cc1cc(F)ccc1N1CCN(C(=O)c2cccc(Cl)c2Cl)CC1=O CHEMBL2218151 pIC50 3.981 nM
N#Cc1cc(F)ccc1N1CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)CC1=O CHEMBL2218179 pIC50 3.981 nM
CN1C(=O)N(c2ncc(F)cn2)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218371 pIC50 3.981 nM
CCN1C(=O)NC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218374 pIC50 3.981 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2ccc(F)cc2)C1 CHEMBL2218589 pIC50 3.981 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(I)cnc2C1 CHEMBL2218675 pIC50 3.981 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(-c3ccc(F)cn3)cnc2C1 CHEMBL2218139 pIC50 3.981 nM
O=C(c1ccc(F)cc1Cl)N1CCn2c(-c3cnccn3)cnc2C1 CHEMBL2218325 pIC50 3.981 nM
O=C1c2nnc(-c3cnccn3)n2CC(C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663284 IC50 4.0 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(ncn2-c2ccccn2)C1 CHEMBL3906769 IC50 4.0 nM
C[C@@H]1c2ncn(-c3ccc(F)cn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3895947 IC50 4.0 nM
Cc1c(F)cccc1C(=O)NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1 CHEMBL3679038 IC50 4.0 nM
O=C(NCC(c1ccc(F)nc1)N1CCC(F)(F)CC1)c1ccccc1Cl CHEMBL3964535 IC50 4.0 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2nc(Cl)ccc12 CHEMBL4175875 IC50 4.0 nM
Cc1ccc(CO)cc1Nc1nc(=O)ccn1Cc1cc(F)c(F)c(F)c1 CHEMBL5416813 IC50 4.0 nM
O=C(NC[C@H](c1cnc(C(F)(F)F)nc1)C1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3936749 IC50 4.1 nM
O=C(NC1CCc2cc(Cl)cc(Cl)c21)C1COc2ncsc21 CHEMBL3969345 IC50 4.1 nM
O=C(NCc1c(Cl)cc(Cl)cc1Br)C1COc2ncccc21 CHEMBL3980492 IC50 4.1 nM
COc1cccc(C(=O)NCC(CC2CC2)c2ccc(C(F)(F)F)nc2)c1Cl CHEMBL3679066 IC50 4.2 nM
CC1c2nnn(-c3cnccn3)c2C=CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3967077 IC50 4.2 nM
C[C@@H]1Cn2c(nnc2-c2cc(O[11CH3])ccn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL5200183 IC50 4.2 nM
N#Cc1cccc(S(=O)(=O)Oc2ccc(-c3cncn3C3CCN(C(=O)c4ccc(Cl)c(C(F)(F)F)c4)CC3)cc2)c1 CHEMBL4529050 IC50 4.28 nM
O=C1c2nnc(-c3cccnc3)n2CC(C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663290 IC50 4.3 nM
C[C@H]1Cn2c(nnc2-c2cncc(Cl)c2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663275 IC50 4.3 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)C1CCC(F)(F)CC1)c1cccc(Cl)c1Cl CHEMBL3679144 IC50 4.3 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncsc21 CHEMBL3985752 IC50 4.3 nM
Cc1nc2c(s1)C(C(=O)NCc1c(C)cc(Cl)cc1Cl)CCC2 CHEMBL3925176 IC50 4.3 nM
COCc1cc(Cl)cc(Cl)c1CNC(=O)C1CCCc2ncsc21 CHEMBL3938249 IC50 4.3 nM
Cc1ccc(C(CNC(=O)c2cccc(C)c2C)CC(C)C)cn1 CHEMBL3679006 IC50 4.4 nM
COc1cccc(C(=O)NCC(CC2CC2)c2ccc(C(F)F)nc2)c1Cl CHEMBL3679154 IC50 4.4 nM
O=C(c1cccc(Cl)c1Cl)N1CCc2c(ncnc2-n2nccn2)C1 CHEMBL3674055 IC50 4.5 nM
O=C(NCC(CC1(C(F)(F)F)CC1)c1cnc(C(F)(F)F)nc1)c1cccc(F)c1Cl CHEMBL3679114 IC50 4.5 nM
O=C(NCc1c(Cl)cc(Cl)cc1Br)C1CCc2ncsc21 CHEMBL3895198 IC50 4.5 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(-c3cnccn3)n[nH]c2C1 CHEMBL3979405 IC50 4.5 nM
C[C@H]1CCC[C@@](O)(CNC(=O)c2c(Cl)ccc3nc(N4CC[C@@H](F)C4)ccc23)C1 CHEMBL4531148 IC50 4.5 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2cnnc2[C@H]1c1ccccc1 CHEMBL4465051 IC50 4.5 nM
O=C(NCC(c1ccc(F)cc1)c1ccc(C(F)(F)F)nc1)c1cccc(F)c1Cl CHEMBL3679128 IC50 4.6 nM
O=C(Cc1cccc(C(F)(F)F)c1Cl)NC1COc2cnccc21 CHEMBL3949105 IC50 4.6 nM
O=C(NCC(CC1CC1)c1cnc(C(F)(F)F)nc1)c1cccc(F)c1Cl CHEMBL3679088 IC50 4.7 nM
O=C(Cc1cccc(C(F)(F)F)c1Cl)NC1COc2ncccc21 CHEMBL3952549 IC50 4.7 nM
O=C(NCc1cccc(C(F)(F)F)c1Cl)C1CCc2ncsc21 CHEMBL3960528 IC50 4.7 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(Cl)cccc1Cl CHEMBL3974445 IC50 4.7 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(F)cc(Cl)cc1Cl CHEMBL3908413 IC50 4.7 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(nnn2-c2ccccc2)C1 CHEMBL3936758 IC50 4.7 nM
CC1c2nnn(-c3ncccn3)c2CCN1C(=O)c1ccc(Cl)cc1Cl CHEMBL3961280 IC50 4.7 nM
CC(C)(O)c1ccc(C(=O)N2CCC(n3cncc3-c3ccc(OS(=O)(=O)c4cccc5cnccc45)cc3)CC2)cc1 CHEMBL4573595 IC50 4.7 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1(F)COc2ncccc21 CHEMBL3914314 IC50 4.8 nM
O=C(NCC(c1cnc(C(F)F)nc1)N1CCOCC1)c1cccc(F)c1Cl CHEMBL3895641 IC50 4.8 nM
C[C@H]1Cc2c(nnn2-c2ncc(F)cn2)CN1C(=O)c1ccnc(C(F)(F)F)c1F CHEMBL3914857 Ki 4.8 nM
CC1Cc2c(nnn2-c2ncccc2F)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3933125 IC50 4.8 nM
C[C@H]1Cc2c(nnn2-c2ncc(F)cn2)CN1C(=O)c1cccc(C(F)(F)F)c1F CHEMBL3919664 IC50 4.8 nM
Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCCc2nc(N)sc21 CHEMBL3955065 IC50 4.9 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(Cl)ccc(F)c1Cl CHEMBL3898016 IC50 4.9 nM
O=C(NCC1CCCC(F)(F)C1)c1c(Cl)ccc2nc(N3CC[C@@H](F)C3)ccc12 CHEMBL4525220 IC50 4.9 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2 CHEMBL3697539 IC50 5.0 nM
CC1c2ncn(-c3ccccc3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3901310 IC50 5.0 nM
CC1Cc2c(nnn2-c2cc[nH]n2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3890005 Ki 5.0 nM
C[C@H]1Cc2c(nnn2-c2cnccn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3923283 Ki 5.0 nM
C[C@@H]1c2nnn(-c3ccn[nH]3)c2C[C@H](C)N1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3904187 Ki 5.0 nM
C[C@@H]1Cc2c(nnn2-c2ccn[nH]2)[C@H](C)N1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4106884 IC50 5.0 nM
Nc1cccc(Cl)c1C(=O)NCC12CC3CC(CC(C3)C1)C2 CHEMBL131774 pA2 5.012 nM
COc1cccc(NC(=O)CC23CC4CC(CC(C4)C2)C3)c1C CHEMBL341226 pA2 5.012 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(Cl)ccc1Cl CHEMBL131162 pA2 5.012 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CN2C[C@@H]3C[C@H]2CN3)ccc1Cl CHEMBL392559 pA2 5.012 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(NC2CCCNC2)ccc1Cl CHEMBL392378 pA2 5.012 nM
O=C(NNc1cccc2ncccc12)C12CC3CC(CC(C3)C1)C2 CHEMBL497967 pIC50 5.012 nM
Cc1ncccc1N1C[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2Cl)N(C)C1=O CHEMBL1271656 pIC50 5.012 nM
Cc1n[nH]c(C)c1CC(=O)NCc1cccc(Cl)c1C CHEMBL2094206 pIC50 5.012 nM
Cc1n[nH]c(C(F)(F)F)c1CC(=O)NCc1ccc(F)c(F)c1Cl CHEMBL2094248 pIC50 5.012 nM
CC(C)N1C(=O)CC[C@H]1C(=O)NCc1ccc(F)c(Cl)c1Cl CHEMBL2218290 pIC50 5.012 nM
O=C(NCc1ccc(Cl)cc1Cl)[C@@H]1CCC(=O)N1C1CCC1 CHEMBL2218314 pIC50 5.012 nM
CCN1C(=O)C(C)(C)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218697 pIC50 5.012 nM
Cc1cccc(N2CCN(Cc3ccc(F)cc3Cl)C(=O)C2=O)c1C CHEMBL2218704 pIC50 5.012 nM
Cc1ccccc1N1CCN(Cc2c(C)cc(Cl)cc2Cl)C(=O)C1=O CHEMBL2218465 pIC50 5.012 nM
Cc1cccnc1N1C[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2Cl)N(C)C1=O CHEMBL2218552 pIC50 5.012 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCN(c2ccccc2Cl)C(=O)C1 CHEMBL2218631 pIC50 5.012 nM
CN1C(=O)N(c2cncn2C)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218149 pIC50 5.012 nM
CN1C(=O)N(c2cccnc2Cl)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218357 pIC50 5.012 nM
CN1C[C@@H](C(=O)NCc2c(F)cc(Cl)cc2Cl)N(C)C1=O CHEMBL2218568 pIC50 5.012 nM
CN1C(=O)N(CC2CCC2)CC1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218572 pIC50 5.012 nM
CC(C)N1CC(C(=O)NCc2ccc(Cl)cc2Cl)N(C)C1=O CHEMBL2218573 pIC50 5.012 nM
CN1C(=O)N(C2CCCC2)CC1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218575 pIC50 5.012 nM
O=C(c1cccc(Cl)c1Cl)N1CCN(c2cc(N3CCOCC3)ccc2Cl)C(=O)C1 CHEMBL2218581 pIC50 5.012 nM
O=C(c1cccc(Cl)c1Cl)N1CCn2c(-c3ccccc3)cnc2C1 CHEMBL2218587 pIC50 5.012 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nc(C(F)(F)F)c2Br)C1 CHEMBL2218677 pIC50 5.012 nM
Cn1ccc(-c2nnc3n2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)C3)n1 CHEMBL2218114 pIC50 5.012 nM
O=C(c1ccc(F)cc1Cl)N1CCn2c(nnc2-c2cnccn2)C1 CHEMBL2218117 pIC50 5.012 nM
O=C(c1cccc(C(F)(F)F)c1F)N1CCn2c(nnc2-c2ccccn2)C1 CHEMBL2218135 pIC50 5.012 nM
O=C(NCC1(N2CCN(c3ccccc3)CC2)CCOCC1)c1cccnc1Sc1ccccc1 CHEMBL2338352 pIC50 5.012 nM
Cc1ncc(C(CNC(=O)c2cc(F)cc(Cl)c2Cl)N2CCC(F)(F)CC2)cn1 CHEMBL3963763 IC50 5.1 nM
CC1c2nnn(-c3ncc(F)cn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3950699 IC50 5.1 nM
C[C@H]1c2nnn(-c3ncc(F)cn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1F CHEMBL3891769 IC50 5.1 nM
O=C(NCc1c(Cl)cc(Cl)cc1CO)C1CCOc2ncsc21 CHEMBL3951252 IC50 5.2 nM
Cc1ccnc(-n2nnc3c2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)[C@@H]3C)c1 CHEMBL4108260 IC50 5.2 nM
O=C(NCC1(c2ccc(F)nc2)CCC(F)(F)CC1)c1cccc(F)c1Cl CHEMBL3679079 IC50 5.3 nM
O=C(NCC(c1cnc(C2CC2)nc1)N1CCC(F)(F)CC1)c1c(Cl)cccc1Cl CHEMBL3892715 IC50 5.3 nM
CCOCc1cn(-c2ccc(Cl)cc2)nn1 CHEMBL4162056 IC50 5.3 nM
Cc1ccnc(-n2nnc3c2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)[C@@H]3C)n1 CHEMBL4095741 pIC50 5.37 nM
Cn1nc2c(c1-c1ccccn1)CCN(C(=O)c1cccc(C(F)(F)F)c1Cl)C2 CHEMBL3952152 IC50 5.4 nM
O=C(NCC(CC1CC1)c1cncc(Cl)c1)c1cccc(Cl)c1Cl CHEMBL3679045 IC50 5.5 nM
O=C(NC1CCc2cccc(Cl)c21)C1COc2ncccc21 CHEMBL3928232 IC50 5.5 nM
O=C(NCC(c1ccc(C(F)F)nc1)N1CCC(F)(F)CC1)c1c(Cl)cccc1Cl CHEMBL3926471 IC50 5.5 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1C=Cc2c(nnn2-c2cnccn2)C1 CHEMBL3897182 IC50 5.5 nM
Cc1cncc2c1C(NC(=O)Cc1cccc(C(F)(F)F)c1Cl)CO2 CHEMBL3966913 IC50 5.6 nM
O=C(NCc1c(Cl)cc(Cl)cc1CO)C1CCOc2ncccc21 CHEMBL3890921 IC50 5.6 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1ccc(Cl)cc1Cl CHEMBL3892045 IC50 5.6 nM
CC1c2ncnc(-c3ccn[nH]3)c2CCN1C(=O)c1ccc(F)c(Cl)c1Cl CHEMBL3674131 IC50 5.7 nM
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCC(Cl)CC2)cn1 CHEMBL3934165 IC50 5.7 nM
COc1ccnc(-n2nnc3c2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)[C@H]3C)c1 CHEMBL3945419 IC50 5.7 nM
Cc1ccc(N2CCCC2=O)cc1Nc1nc(=O)cnn1Cc1cc(F)c(F)c(F)c1 CHEMBL5399698 IC50 5.7 nM
CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)S(=O)(=O)c1cccc2cnccc12 CHEMBL282807 IC50 5.8 nM
CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1)S(=O)(=O)c1cccc2cnccc12 CHEMBL282173 IC50 5.8 nM
C[C@@H]1c2ncnc(-c3ccn[nH]3)c2CCN1C(=O)c1ccc(Cl)c(F)c1Cl CHEMBL3674135 IC50 5.8 nM
Cc1c(C(=O)N2CCc3c(nnn3-c3cnccn3)C2)cccc1C(F)(F)F CHEMBL3967445 Ki 5.8 nM
O=C(c1ccc(Cl)c(F)c1Cl)N1CCc2c(ncnc2-c2ccn[nH]2)C1 CHEMBL3674052 IC50 5.9 nM
C[C@@H]1c2ncnc(-c3ccn[nH]3)c2CCN1C(=O)c1ccc(F)c(C(F)(F)F)c1Cl CHEMBL3674129 IC50 5.9 nM
C[C@H]1Cc2c(nnn2-c2ccccc2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3938418 Ki 5.9 nM
CC1Cc2c(nnn2-c2ccccn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3957535 IC50 5.9 nM
Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(OCc2cccc(F)c2)CC1 CHEMBL5423932 IC50 5.95 nM
O=C([C@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)NS(=O)(=O)c1cccc2cnccc12)N1CCN(c2ccc(F)cc2)CC1 CHEMBL282552 IC50 6.0 nM
Cc1nc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)cs1 CHEMBL1824020 IC50 6.0 nM
Cc1ccc(-c2ccnn(C)c2=O)cc1NC(=O)C1=CN(C)C(=O)C[C@H]1c1ccc(F)cc1 CHEMBL3739648 IC50 6.0 nM
Cc1cccc(-n2nnc3c2CCN(C(=O)c2cccc(Cl)c2Cl)C3C)n1 CHEMBL3912077 IC50 6.0 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2nc(-c3ccc(O)cc3)ccc12 CHEMBL4175330 IC50 6.0 nM
O=C(c1ccc(Cl)c(F)c1Cl)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2 CHEMBL3697544 IC50 6.1 nM
O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCOCC1)c1c(F)cccc1Cl CHEMBL3933079 IC50 6.1 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)CC1)c1c(Cl)cccc1Cl CHEMBL3907553 IC50 6.1 nM
COc1ccc(NC(=O)N2CCN(c3c(Nc4ccccc4C)c(=O)c3=O)CC2c2ccccc2)cc1OC CHEMBL5093653 IC50 6.1 nM
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)C2CCC(F)(F)CC2)cn1 CHEMBL3679108 IC50 6.2 nM
O=C(NCC(c1ccncc1)c1cnc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679131 IC50 6.2 nM
CC1c2nnn(-c3ncccn3)c2C=CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3897781 IC50 6.2 nM
O=C(c1cccc(Cl)c1Cl)N1CCc2c(-c3ccccc3)n[nH]c2C1 CHEMBL3955703 IC50 6.2 nM
Cc1ccnc(-n2nnc3c2CCN(C(=O)c2cccc(Cl)c2Cl)C3C)n1 CHEMBL3904138 IC50 6.2 nM
C[C@H]1Cn2c(nnc2-c2ccccn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604424 IC50 6.3 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@H]2CC[C@@H]1c1nnc(-c3ccccn3)n1C2 CHEMBL3697531 IC50 6.3 nM
C[C@H]1Cn2c(nnc2-c2cnco2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663248 Ki 6.3 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@H]2CC[C@@H]1c1nnc(-c3ccc[nH]3)n1C2 CHEMBL3697552 Ki 6.3 nM
C[C@H]1Cn2c(nnc2-c2cncc(F)c2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663269 Ki 6.3 nM
Cc1nc2c(c(-c3ccn[nH]3)n1)C[C@@H](C)N(C(=O)c1cccc(C(F)(F)F)c1F)C2 CHEMBL3674094 Ki 6.3 nM
O=C1c2nnc(-c3cnccn3)n2CCN1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663230 Ki 6.3 nM
C[C@H]1Cn2c(nnc2-c2ccc(Cl)cn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663279 Ki 6.3 nM
O=C(NCc1c(Cl)cc(Cl)cc1CO)C1CCc2ncsc21 CHEMBL3933502 IC50 6.3 nM
O=C(NCC1(c2ccc(Cl)nc2)CCC(F)(F)CC1)C1CCCc2ncsc21 CHEMBL3976032 IC50 6.3 nM
O=C(NCC1(c2ccc(Cl)nc2)CCCCC1)C1CCOc2ncccc21 CHEMBL3980073 IC50 6.3 nM
CC1Cc2c(nnn2-c2ccccn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3936551 Ki 6.3 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(nnn2-c2ncccn2)C1 CHEMBL3934656 IC50 6.3 nM
Nc1cccc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1Cl CHEMBL134194 pA2 6.31 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CC2CCCNC2)ccc1Cl CHEMBL392558 pA2 6.31 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(O[C@@H]2CCCNC2)ccc1Cl CHEMBL235357 pA2 6.31 nM
CNC[C@H](O)c1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 CHEMBL563379 pIC50 6.31 nM
O=C(Cc1ccc(C(F)(F)F)c(F)c1)Nc1c(Cl)ccc2c(=O)n(CCO)ccc12 CHEMBL563255 pIC50 6.31 nM
CCN1C(=O)CC[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL1222820 pIC50 6.31 nM
CN1C(=O)CC[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1C#N CHEMBL2218695 pIC50 6.31 nM
CN1C(=O)N(c2ccccn2)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218524 pIC50 6.31 nM
CN1C(=O)N(c2ncccn2)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218542 pIC50 6.31 nM
Cc1cccc(C)c1N1CCN(Cc2cccc(C(F)(F)F)c2Cl)C(=O)C1=O CHEMBL2218086 pIC50 6.31 nM
Cc1cccc(C)c1N1CCN(Cc2cccc(Cl)c2Cl)C(=O)C1=O CHEMBL2218087 pIC50 6.31 nM
Cc1c(Br)cccc1N1CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)CC1=O CHEMBL2218166 pIC50 6.31 nM
CCC(CC)N1CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)CC1=O CHEMBL2218168 pIC50 6.31 nM
Cc1c(Cl)cccc1CNC(=O)[C@@H]1CN(C)C(=O)N1C CHEMBL2218375 pIC50 6.31 nM
CN1C(=O)N(c2ncc(Cl)cn2)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218384 pIC50 6.31 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(-c3ccccc3)cnc2C1 CHEMBL2218566 pIC50 6.31 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2-c2cccnc2)C1 CHEMBL2218666 pIC50 6.31 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nc(I)c2I)C1 CHEMBL2218673 pIC50 6.31 nM
Cn1cccc1-c1nnc2n1CCN(C(=O)c1cccc(C(F)(F)F)c1Cl)C2 CHEMBL2218115 pIC50 6.31 nM
Cn1ccc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2Cl)C3)n1 CHEMBL2218127 pIC50 6.31 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)C1CCC(F)(F)CC1)c1ccccc1Cl CHEMBL3679143 IC50 6.4 nM
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCC(F)CC2)cn1 CHEMBL3935570 IC50 6.5 nM
CN(C)c1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCC(F)(F)CC2)cn1 CHEMBL3929243 IC50 6.6 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(-c3ncccn3)n[nH]c2C1 CHEMBL3942735 IC50 6.6 nM
Clc1cccc(-n2nnnc2NCc2ccccc2Oc2ccccn2)c1Cl CHEMBL1628691 pIC50 6.607 nM
Cc1cc(Cl)cc(Cl)c1CC(=O)NC1COc2nnccc21 CHEMBL3956732 IC50 6.7 nM
C[C@@H](NC(=O)C1CCCc2ncsc21)c1ccc(Cl)cc1Cl CHEMBL3918501 IC50 6.7 nM
O=C(NCc1cccc(C(F)(F)F)c1Cl)C1CCOc2ncsc21 CHEMBL3918095 IC50 6.9 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(C3CC3)nnc2[C@H]1c1ccccc1 CHEMBL4546974 IC50 6.9 nM
C[C@H]1Cn2c(nnc2-c2cc(F)ccn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604429 IC50 7.0 nM
Cc1ncc(C(CNC(=O)c2cccc(OC(F)F)c2Cl)N2CCC(F)(F)CC2)cn1 CHEMBL3901667 IC50 7.0 nM
C[C@@H]1c2nnn(-c3ccccc3)c2C[C@H](C)N1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3971489 IC50 7.0 nM
COC(=O)c1ccc(-c2ccc3c(NC(=O)CC45CC6CC(CC(C6)C4)C5)cccc3n2)cc1 CHEMBL4159289 IC50 7.0 nM
CS(=O)(=O)c1ccc(C(=O)N2CCC(c3nc4cc(OS(=O)(=O)c5cccc6cnccc56)ccc4[nH]3)CC2)cc1 CHEMBL4594110 IC50 7.0 nM
COc1cccc(C(=O)NCC2(c3ccc(C(F)(F)F)nc3)CCC(F)(F)CC2)c1Cl CHEMBL3679077 IC50 7.1 nM
O=C(NCC(CC1(C(F)(F)F)CC1)c1ccc(C(F)(F)F)nc1)c1cccc(F)c1Cl CHEMBL3679116 IC50 7.2 nM
Cc1cccc(-n2nnc3c2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)[C@H]3C)n1 CHEMBL3936619 IC50 7.2 nM
Cc1c(C(=O)N2CCc3c(nnn3-c3cnccn3)C2C)cccc1C(F)(F)F CHEMBL3936653 IC50 7.2 nM
Cc1ccc(C2(CNC(=O)c3cccc(Cl)c3Cl)CCC(F)(F)CC2)cn1 CHEMBL3679076 IC50 7.3 nM
O=C(NCc1c(Cl)cc(Cl)cc1Br)C1COc2ncsc21 CHEMBL3962489 IC50 7.3 nM
O=C(NCC1(c2ccc(Cl)nc2)CCC(F)(F)CC1)C1CCOc2ncccc21 CHEMBL3916143 IC50 7.3 nM
C[C@@H]1CCC[C@@](O)(CNC(=O)c2c(Cl)ccc3nc(N4CC[C@@H](C(C)(C)O)C4)ccc23)C1 CHEMBL4453695 IC50 7.4 nM
FC(F)(F)c1cccc(-c2nnnn2Cc2cccnc2)c1Cl CHEMBL437703 Ki 7.4 nM
Cc1c(Cl)cccc1CNC(=O)C1CCCc2ncsc21 CHEMBL3923529 IC50 7.5 nM
O=C(NCc1ccc(Cl)cc1Cl)C1CCCc2ncsc21 CHEMBL3932882 IC50 7.5 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(Cl)cc(F)cc1Cl CHEMBL3920401 IC50 7.5 nM
O=C(c1cccc(Cl)c1Cl)N1CCc2c(nnn2-c2cnccn2)C1 CHEMBL3981471 IC50 7.5 nM
O=C(Cc1cccc(C(F)F)c1Cl)NC1COc2ncccc21 CHEMBL3912536 IC50 7.6 nM
CC1c2nnn(-c3cnccn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1F CHEMBL3898513 IC50 7.6 nM
C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604333 IC50 7.7 nM
COc1ccnc(-c2nnc3n2C[C@H](C)N(C(=O)c2cccc(Cl)c2Cl)C3)c1 CHEMBL3604426 IC50 7.7 nM
Cc1c(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)cccc1C(F)(F)F CHEMBL3697534 IC50 7.7 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1C2CCCC1c1nnc(-c3cscn3)n1C2 CHEMBL3697515 IC50 7.7 nM
CC1Cc2c(ncnc2-c2ccn[nH]2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3674081 IC50 7.8 nM
COc1ccc(C(=O)NCC(c2cnc(C(F)(F)F)nc2)N2CCC(F)(F)CC2)c(Cl)c1OC CHEMBL3919238 IC50 7.8 nM
O=C(c1cccc(Cl)c1Cl)N1CCn2c(nnc2-c2ccccn2)C1 CHEMBL3604319 IC50 7.9 nM
Cc1nc2c(c(-c3ccn[nH]3)n1)C[C@@H](C)N(C(=O)c1ccc(F)c(Cl)c1Cl)C2 CHEMBL3674100 Ki 7.9 nM
O=C1c2nnc(-c3ncc(F)cn3)n2CC(C2CC2)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663293 IC50 7.9 nM
Cc1nc2c(c(-c3ccn[nH]3)n1)C[C@@H](C)N(C(=O)c1cccc(C(F)(F)F)c1C)C2 CHEMBL3674097 Ki 7.9 nM
C[C@H]1Cn2c(nnc2-c2ncc(Br)cn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663267 Ki 7.9 nM
CC1Cc2c(nnn2-c2ncc(F)cn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3928889 Ki 7.9 nM
CC1Cc2c(nnn2-c2ccccc2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3932924 Ki 7.9 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(-c3ccccn3)n[nH]c2C1 CHEMBL3923235 IC50 7.9 nM
O=C(NCc1cccc(C(F)(F)F)c1Cl)[C@@H]1CCC(=O)N1CC[18F] CHEMBL5194016 IC50 7.9 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)c1ccccc1Cl CHEMBL336619 pA2 7.943 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2nc(NCCCO)ccc12 CHEMBL551301 pIC50 7.943 nM
Cc1cc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCC(C)(C)C3)c2)n[nH]1 CHEMBL560616 pIC50 7.943 nM
Cc1n[nH]c(C)c1CC(=O)NCc1ccc(Cl)cc1Cl CHEMBL1210558 pIC50 7.943 nM
CCN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)c(F)c1Cl CHEMBL2218775 pIC50 7.943 nM
CCN1C(=O)CCC[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218280 pIC50 7.943 nM
CC(C)N1C(=O)CC[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218296 pIC50 7.943 nM
CN1C[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2F)N(C)C1=O CHEMBL2218494 pIC50 7.943 nM
Cc1ccc(C)c(N2CCN(Cc3ccc(F)cc3Cl)C(=O)C2=O)c1 CHEMBL2218460 pIC50 7.943 nM
CN1C(=O)N(c2ccccn2)CC1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218463 pIC50 7.943 nM
CN1C(=O)N(c2ncccn2)C[C@H]1C(=O)NCc1ccc(F)c(F)c1Cl CHEMBL2218544 pIC50 7.943 nM
Cc1c(Cl)cccc1CNC(=O)[C@@H]1CN(c2ncccn2)C(=O)N1C CHEMBL2218547 pIC50 7.943 nM
CC(C)c1ccccc1N1CCN(Cc2ccc(F)cc2Cl)C(=O)C1=O CHEMBL2218648 pIC50 7.943 nM
O=C1C(=O)N(c2ccccc2I)CCN1Cc1ccc(F)cc1Cl CHEMBL2218731 pIC50 7.943 nM
CC(C)c1ccccc1N1CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)CC1=O CHEMBL2218749 pIC50 7.943 nM
Cc1cccc(C)c1N1CCN(Cc2ccc(F)cc2C(F)(F)F)C(=O)C1=O CHEMBL2218089 pIC50 7.943 nM
Cc1ccc(N2C[C@@H](C(=O)NCc3cccc(C(F)(F)F)c3Cl)N(C)C2=O)c(C)n1 CHEMBL2218098 pIC50 7.943 nM
CN1C(=O)N(c2cn(C)cn2)C[C@H]1C(=O)NCc1ccc(Cl)cc1Cl CHEMBL2218109 pIC50 7.943 nM
CN1C(=O)N(c2ccc(F)nc2)C[C@H]1C(=O)NCc1cccc(C(F)(F)F)c1Cl CHEMBL2218165 pIC50 7.943 nM
CCN1C(=O)N(C)C[C@H]1C(=O)NCc1ccc(F)cc1Cl CHEMBL2218175 pIC50 7.943 nM
COc1ccc(N2C[C@@H](C(=O)NCc3cccc(C(F)(F)F)c3Cl)N(C)C2=O)cn1 CHEMBL2218177 pIC50 7.943 nM
Cc1cc(Cl)ccc1CNC(=O)[C@@H]1CN(C)C(=O)N1C CHEMBL2218391 pIC50 7.943 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(Br)nnc2C1 CHEMBL2218576 pIC50 7.943 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCN(c2cc(N3CCOCC3)ccc2Cl)C(=O)C1 CHEMBL2218583 pIC50 7.943 nM
Cc1cnc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)nc1 CHEMBL1094738 IC50 8.0 nM
C[C@H]1Cn2c(nnc2-c2cnccn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604422 IC50 8.0 nM
Cc1nc2c(c(-c3ccn[nH]3)n1)CCN(C(=O)c1cccc(C(F)(F)F)c1Cl)C2 CHEMBL3674061 IC50 8.0 nM
Cc1cc(F)c(-c2ccnn(C)c2=O)cc1NC(=O)C1=CN(C)C(=O)C[C@H]1c1ccc(F)cc1 CHEMBL3740684 IC50 8.0 nM
CC1Cc2c(nnn2-c2cc(F)ccn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3897237 IC50 8.0 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2nc(-c3ccc(C(=O)O)cc3)ccc12 CHEMBL4169592 IC50 8.0 nM
CS(=O)(=O)c1ccc(Cl)c(C(=O)NCC(CC2CC2)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3679070 IC50 8.1 nM
CC1Cc2c(-c3ccn[nH]3)n[nH]c2CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3906207 IC50 8.1 nM
Cc1ccnc(-n2nnc3c2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)C3C)c1 CHEMBL3932188 IC50 8.1 nM
CC1Cn2c(nnc2-c2ccccc2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3604329 IC50 8.2 nM
Cc1nc(-c2nnc3n2C[C@H](C)N(Cc2cccc(C(F)(F)F)c2Cl)C3=O)cs1 CHEMBL3663261 IC50 8.2 nM
O=C(NCC(c1ccc(C2CC2)nc1)N1CCOCC1)c1cccc(Cl)c1Cl CHEMBL3901156 IC50 8.2 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(F)cccc1Cl CHEMBL3912349 IC50 8.2 nM
COc1cccc(C(=O)NCC(c2cnc(C(F)(F)F)nc2)N2CCOCC2)c1Cl CHEMBL3933293 IC50 8.2 nM
O=C(NCC1CCC(F)(F)CC1)c1c(Cl)ccc2nc(N3CC[C@H](F)C3)ccc12 CHEMBL4453785 IC50 8.2 nM
C[C@@H]1c2nnn(-c3cc(F)ccn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL4094806 pIC50 8.318 nM
O=C(NC[C@@H](c1cnc(C(F)(F)F)nc1)C1CCC(F)(F)CC1)c1c(F)cccc1Cl CHEMBL4108735 IC50 8.4 nM
CC1c2nnc(-c3ccccn3)n2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3604321 IC50 8.5 nM
O=C(NCC(c1ccc(F)cc1)c1ccc(C(F)(F)F)nc1)c1c(F)cccc1Cl CHEMBL3679127 IC50 8.5 nM
CCCCc1nnc2n1CCN(C(=O)c1cccc(C(F)(F)F)c1Cl)[C@@H]2c1ccccc1 CHEMBL4450832 IC50 8.5 nM
Cc1ncc(C2(CNC(=O)c3cccc(Cl)c3Cl)CCC(F)(F)CC2)cn1 CHEMBL3679062 IC50 8.6 nM
C[C@H]1Cc2c(nnn2-c2cc(F)ccn2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3956185 IC50 8.6 nM
CC1c2nnn(-c3ncco3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3923816 IC50 8.6 nM
CC1c2nnn(-c3cnccn3)c2CCN1C(=O)c1ccc(Cl)cc1Cl CHEMBL3899670 IC50 8.6 nM
C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)CN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3604421 IC50 8.7 nM
CS(=O)(=O)c1ccc(Cl)c(C(=O)NCC2(c3ccc(F)nc3)CCC(F)(F)CC2)c1 CHEMBL3679016 IC50 8.7 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCn2c(nnc2C(F)(F)F)[C@H]1c1ccccc1 CHEMBL4077415 IC50 8.7 nM
O=C(NCc1cccc(Cl)c1Cl)C1CCCc2ncsc21 CHEMBL3945300 IC50 8.9 nM
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCCCC2)cn1 CHEMBL3955995 IC50 8.9 nM
COc1ccc(F)c(C(=O)NCC(c2cnc(C(F)(F)F)nc2)N2CCC(F)(F)CC2)c1Cl CHEMBL3944085 IC50 8.9 nM
C[C@H]1c2nnn(-c3ccn(C)n3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3983427 IC50 8.9 nM
CC1Cc2c(nnn2-c2cc(F)ccn2)CN1C(=O)c1cccc(Cl)c1Cl CHEMBL3946102 IC50 8.9 nM
C[C@H](N/C(=N/C#N)Nc1cccc2ncccc12)c1ccccc1 CHEMBL1628690 Ki 8.9 nM
COc1cc(Br)c(NC(=O)N2C=CC(=O)C[C@H]2c2ccc(F)cc2)cc1OC CHEMBL3741934 IC50 9.0 nM
Cc1cc(Cl)c(OCCO)cc1NC(=O)N1C=CC(=O)C[C@H]1c1ccc(F)cc1 CHEMBL3741412 IC50 9.0 nM
COc1cc(Br)c(NC(=O)C2=CNC(=O)C[C@H]2c2cccc(F)c2)cc1OC CHEMBL3740237 IC50 9.0 nM
COc1cc(C)c(C)c(NC(=O)C2=CNC(=O)C[C@H]2c2ccc(F)cc2)c1 CHEMBL3741668 IC50 9.0 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(ncn2-c2cnccn2)C1 CHEMBL3947089 IC50 9.0 nM
CC1c2ncn(-c3ncccc3F)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3913899 IC50 9.0 nM
Nc1ccc2c(C(=O)NCC(c3cnc(C(F)(F)F)nc3)N3CCC(F)(F)CC3)c(Cl)ccc2n1 CHEMBL3894220 IC50 9.0 nM
CC(C(=O)NC1COc2ncccc21)c1ccc(Cl)cc1Cl CHEMBL3940324 IC50 9.0 nM
O=C(Cc1cccc(C(F)(F)F)c1Cl)NC1COc2nnccc21 CHEMBL3965055 IC50 9.0 nM
O=C(NCC(c1ccc(C(F)F)nc1)N1CCC(F)(F)CC1)c1ccccc1Cl CHEMBL3916410 IC50 9.0 nM
Cc1ccc(F)cc1C(=O)NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1 CHEMBL3679040 IC50 9.1 nM
Clc1cccc(-n2ncnc2NCc2cccnc2N2CCC2)c1Cl CHEMBL401822 pIC50 9.12 nM
Clc1cccc(-n2ncnc2NCc2cccnc2)c1Cl CHEMBL270421 pIC50 9.12 nM
CC12CC3CC(C)(C1)CC(C(=O)NNc1c(Cl)cncc1Cl)(C3)C2 CHEMBL2048438 IC50 9.2 nM
C[C@H]1Cn2c(nnc2-c2ccncc2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl CHEMBL3663271 IC50 9.3 nM
O=C(NCC(CC1(F)CC1)c1cnc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679100 IC50 9.3 nM
Cc1ccccc1C(=O)NC[C@H](c1ccc(Cl)cc1)N1CCOCC1 CHEMBL4115321 IC50 9.3 nM
COc1ccnc(-n2nnc3c2CCN(C(=O)c2cccc(C(F)(F)F)c2Cl)C3)c1 CHEMBL3963279 IC50 9.3 nM
Cc1ccc2c(=O)n(C(C)CO)ccc2c1NC(=O)Cc1ccc(C(F)(F)F)c(F)c1 CHEMBL5401723 IC50 9.3 nM
O=C(NCC(c1ccc(F)cc1)c1ccc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl CHEMBL3679126 IC50 9.4 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(F)cc(F)cc1Cl CHEMBL3910030 IC50 9.4 nM
O=C(N[C@@H]1CCCc2cccc(Cl)c21)C1COc2ncccc21 CHEMBL3944492 IC50 9.5 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@@H]2CCC[C@H]1c1nnc(-c3ncccn3)n1C2 CHEMBL3697511 IC50 9.6 nM
Cc1ncc(C(CNC(=O)c2c(Cl)cccc2Cl)N2CCC(F)CC2)cn1 CHEMBL3928959 IC50 9.6 nM
O=C(c1cccc(C(F)(F)F)c1Cl)N1[C@H]2CCC[C@@H]1c1nnc(-c3cscn3)n1C2 CHEMBL3697516 IC50 9.7 nM
Cc1ccc(OCCO)cc1Nc1nc(=O)cnn1Cc1cc(F)c(F)c(F)c1 CHEMBL5411789 IC50 9.7 nM
CCOC(=O)C1c2ncn(-c3ccccc3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl CHEMBL3973480 IC50 9.8 nM
Cc1ncc(C(CNC(=O)c2c(Cl)cccc2Cl)CC2CC2)cn1 CHEMBL3679103 IC50 9.9 nM
O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCOCC1)c1cccc(C(F)(F)F)c1Cl CHEMBL3915521 IC50 9.9 nM
O=C(NCC(c1cnc(C2CC2)nc1)N1CCC(F)(F)CC1)c1c(F)cccc1Cl CHEMBL3951764 IC50 9.9 nM