CCn1c(=O)c(-c2ccc(-c3cncc(C)n3)cc2Cl)cc2cnc(NCCC3CCN(C)CC3)nc21 CHEMBL3770186 Ki 0.023 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.212 nM
CCS(=O)(=O)c1cc(Nc2ncc(F)c(N(Cc3ccccc3C#N)c3cc(CO)ccc3C)n2)ccc1N1CCN(C)CC1 CHEMBL3923175 Kd 0.28 nM
CCS(=O)(=O)c1cc(Nc2ncc(F)c(N(Cc3ccccc3F)c3cc(CO)ccc3C)n2)ccc1N1CCN(C)CC1 CHEMBL3950903 IC50 0.35 nM
CCS(=O)(=O)c1cc(Nc2ncc(F)c(N(C)c3cc(CO)c(C)cc3C)n2)ccc1N1CCN(C)CC1 CHEMBL3896232 IC50 0.45 nM
CN(C)C(=O)N1CC[C@H](NC2=Nc3cc(F)ccc3N(CC(F)F)c3ccc(Cl)cc32)C1 CHEMBL5091324 IC50 0.54 nM
CCS(=O)(=O)c1cc(Nc2ncc(F)c(N(C)c3cc(CO)c(C)cc3C)n2)ccc1N1C[C@@H]2C[C@H]1CN2C CHEMBL3964858 IC50 0.58 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CCC3(F)CN(C)C3)c2n1 CHEMBL3818265 Ki 0.95 nM
CN1CCc2cc(-c3cnc4[nH]cc(C(=O)c5ccccc5Cl)c4c3)ccc2C1 CHEMBL3597011 IC50 1.0 nM
CCS(=O)(=O)c1cc(Nc2ncc(F)c(N(Cc3ccccc3)c3cc(CO)ccc3C)n2)ccc1N1CCN(C)CC1 CHEMBL3914181 IC50 1.5 nM
CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](NC)CO3)c2n1 CHEMBL3769478 Ki 1.9 nM
CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(C[C@H]3CC[C@H](N)CC3)c2n1 CHEMBL3770909 Ki 1.9 nM
CCN(c1cc(CO)ccc1C)c1nc(Nc2ccc(N3CCN(C)CC3)c(S(=O)(=O)CC)c2)ncc1F CHEMBL3942173 IC50 2.0 nM
CCNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3CC[C@H](N)CC3)c2n1 CHEMBL3770588 Ki 2.1 nM
CCS(=O)(=O)c1cc(Nc2ncc(F)c(N(C)c3cc(CO)ccc3C)n2)ccc1N1CCN(C)CC1 CHEMBL3924245 IC50 2.1 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CC3CCNCC3(F)F)c2n1 CHEMBL3817856 Ki 2.7 nM
CCn1c(Nc2ccc(N3CCN(C)CC3)cc2)ncc(-c2ccc(-c3cncs3)cc2Cl)c1=O CHEMBL3597013 IC50 2.8 nM
CCS(=O)(=O)c1cc(Nc2ncc(F)c(N(C)c3cc(CO)c(C)cc3C)n2)cc(N2CCOCC2)c1 CHEMBL3933198 IC50 2.8 nM
CCn1c(=O)c(-c2ccc(-c3cncs3)cc2Cl)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21 CHEMBL3609327 IC50 2.8 nM
O=C(c1ccc(COc2ccccc2)cc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596921 IC50 3.0 nM
Cc1cc(C)c(N(C)c2nc(Nc3cc(N4CCOCC4)cc(S(C)(=O)=O)c3)ncc2F)cc1CO CHEMBL3910608 IC50 3.0 nM
CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818046 Ki 3.3 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3819356 Ki 3.5 nM
CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 CHEMBL3770443 Ki 3.7 nM
CN(Cc1ccc2[nH]cnc2c1Cl)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 CHEMBL3580975 Ki 4.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1nc2cc[nH]c2cc1F CHEMBL3824224 Ki 4.0 nM
CC(CO)N(Cc1cc(F)cc2[nH]ncc12)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 CHEMBL2386717 Ki 4.2 nM
CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(CC3COC4(CNC4)OC3)c2n1 CHEMBL3770363 Ki 4.3 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CCOC3CN(C)C3)c2n1 CHEMBL3818828 Ki 4.4 nM
CN1CCc2ccc(-c3cnc4[nH]cc(C(=O)c5ccccc5Cl)c4c3)cc2C1 CHEMBL3596932 IC50 4.5 nM
CNc1ncc2cc(-c3ccc(-n4ccnc(C)c4=O)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818592 Ki 4.6 nM
CCN(Cc1ccc2[nH]cnc2c1Cl)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 CHEMBL3580976 Ki 5.0 nM
Clc1c(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)ccc2[nH]cnc12 CHEMBL3580974 Ki 5.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1cc2cc[nH]c2cn1 CHEMBL3823612 Ki 5.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 5.012 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3(F)F)[nH]n2)n1)c1ccc2[nH]cnc2c1 CHEMBL2386718 Ki 5.13 nM
CC(C)NC(=O)N1CC[C@H](NC2=Nc3cc(F)ccc3N(CC(F)F)c3ccc(Cl)cc32)C1 CHEMBL3609372 IC50 5.2 nM
Cc1nccn(-c2ccc(-c3cc4cnc(NC5COC5)nc4n(CC4CCNCC4(F)F)c3=O)c(Cl)c2)c1=O CHEMBL3818479 Ki 5.2 nM
COc1nn(C)cc1-c1cnc2[nH]cc(C(=O)c3cc(CCO)ccc3Cl)c2c1 CHEMBL3596930 IC50 5.8 nM
COCCn1c(=O)c(-c2ccc(-n3cccc(C)c3=O)cc2Cl)cc2cnc(NC3COC3)nc21 CHEMBL3818016 Ki 5.9 nM
CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CC3CCNCC3)c2n1 CHEMBL3769748 Ki 6.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]cc(Cl)c2n1 CHEMBL3823523 Ki 6.0 nM
CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CCCCN)c2n1 CHEMBL3770369 Ki 6.1 nM
CCn1c(=O)c(-c2ccc(-n3cccc(C)c3=O)cc2Cl)cc2cnc(NC3COC3)nc21 CHEMBL3817984 Ki 6.3 nM
CNc1ncc2cc(-c3ccc(-n4cncc(C)c4=O)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818432 Ki 6.7 nM
C[C@H](Nc1nccc(Nc2cc(C3CCC3)[nH]n2)n1)c1ccc2[nH]ccc2c1 CHEMBL2386716 Ki 6.75 nM
CNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(C[C@H]3CC[C@H](N)CC3)c2n1 CHEMBL3769456 Ki 7.4 nM
O=C(c1ccc(Cl)cc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596915 IC50 7.5 nM
O=C(c1ccc(CO)cc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596919 IC50 7.6 nM
CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@@H]3CCNCC3(F)F)c2n1 CHEMBL3769552 Ki 7.9 nM
CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 CHEMBL3770295 Ki 8.0 nM
CCn1c(=O)c(-c2ccc(-n3cccc(C)c3=O)cc2Cl)cc2cnc(NC)nc21 CHEMBL3817890 Ki 8.0 nM
CCn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc21 CHEMBL3609326 IC50 8.3 nM
Cc1ccc(CO)cc1N(C)c1nc(Nc2ccc(N3CCN(C)CC3)c(S(C)(=O)=O)c2)ncc1F CHEMBL3962678 IC50 8.7 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CC(F)(F)CN)c2n1 CHEMBL3818233 Ki 9.0 nM
CN(c1cc(CO)ccc1Cl)c1nc(Nc2cc(N3CCOCC3)cc(S(C)(=O)=O)c2)ncc1F CHEMBL3980696 IC50 9.6 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCc5ccncc5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4758500 IC50 9.8 nM
CCN1c2ccc(F)cc2N=C(N[C@H]2CCN(C(=O)NC(C)(C)C)C2)c2cc(Cl)ccc21 CHEMBL3609371 Kd 9.9 nM
CCc1cccn(-c2ccc(-c3cc4cnc(NC)nc4n(C[C@H]4CNCCO4)c3=O)c(Cl)c2)c1=O CHEMBL3819118 Ki 11.0 nM
C[C@H](Nc1nccc(Nc2cc([C@H]3C[C@@H]3F)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3824061 Ki 11.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]cnc2c1 CHEMBL3580972 Ki 12.0 nM
CN1CCC(n2cc(-c3cnc4[nH]cc(C(=O)c5ccc(CO)cc5Cl)c4c3)cn2)CC1 CHEMBL3596922 IC50 12.0 nM
O=C(c1ccc(F)cc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596914 IC50 13.0 nM
CNc1ncc2cc(-c3ccc(-n4ccn(C)c4=O)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818372 Ki 13.0 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CCOC)c2n1 CHEMBL3818273 Ki 13.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 IC50 13.7 nM
COc1nn(C)cc1-c1cnc2[nH]cc(C(=O)c3ccc(COc4ccccn4)cc3Cl)c2c1 CHEMBL3596927 IC50 14.0 nM
Cc1ccc(CO)cc1N(C)c1nc(Nc2cc(N3CCOCC3)cc(S(C)(=O)=O)c2)ncc1F CHEMBL3961614 IC50 14.0 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 15.85 nM
CN(Cc1ccc2[nH]cnc2c1Cl)c1nccc(Nc2cc(C3CCC(=O)C3)[nH]n2)n1 CHEMBL3593824 Ki 16.0 nM
CNC(=O)c1n[nH]c2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)ccc12 CHEMBL4742230 IC50 16.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)Nc5ccncc5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4794004 IC50 16.0 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CCO)c2n1 CHEMBL3818138 Ki 17.0 nM
NC1CCN(c2nc(Nc3cc(C4CCC4)[nH]n3)c3sccc3n2)CC1 CHEMBL3580954 Ki 18.0 nM
CN1CC[C@H](c2cc(Nc3ccnc(N(C)Cc4ccc5[nH]cnc5c4Cl)n3)n[nH]2)C1=O CHEMBL3594175 Ki 18.0 nM
CCN1CC[C@H](c2cc(Nc3ccnc(N(C)C[C@H]4CC[C@H](N)CC4)n3)n[nH]2)C1=O CHEMBL3594180 Ki 18.0 nM
O=C(c1ccccc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596899 IC50 18.0 nM
C[C@@H](c1ccc2[nH]ccc2n1)N(C)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 CHEMBL3823457 Ki 18.0 nM
CNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(C[C@H]3CNCCO3)c2n1 CHEMBL3770943 Ki 19.0 nM
Cc1ccc(N(C)c2nc(Nc3cc(N4CCOCC4)cc(S(C)(=O)=O)c3)ncc2F)cc1CO CHEMBL3891484 IC50 19.0 nM
N[C@H]1CC[C@@H](CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580963 Ki 21.0 nM
COCc1ccc(C(=O)c2c[nH]c3ncc(-c4cnn(C5CCNCC5)c4)cc23)c(Cl)c1 CHEMBL3596920 IC50 21.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCCc5ccncc5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4787358 IC50 21.0 nM
NC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)CC1 CHEMBL3580949 Ki 22.0 nM
CNc1ncc2cc(-c3ccc(-n4cncc(C)c4=O)cc3Cl)c(=O)n(CCOC)c2n1 CHEMBL3819447 Ki 22.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCC5CCN(C)CC5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4784979 IC50 22.0 nM
N#Cc1ccc(C(=O)c2c[nH]c3ncc(-c4cnn(C5CCNCC5)c4)cc23)c(Cl)c1 CHEMBL3596916 IC50 23.0 nM
CC[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3824243 Ki 23.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 24.0 nM
Clc1c(CNc2nccc(Nc3cc(C4CCCO4)[nH]n3)n2)ccc2[nH]cnc12 CHEMBL3593823 Ki 25.0 nM
C[C@H](Nc1nccc(Nc2cc([C@@H]3C[C@H]3F)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3823614 Ki 25.0 nM
N[C@H]1CC[C@H](CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580962 Ki 26.0 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3[nH]ccc3c2)n1 CHEMBL3580967 Ki 27.0 nM
COCC(C)c1cc(Nc2ccnc(N(C)Cc3ccc4[nH]cnc4c3Cl)n2)n[nH]1 CHEMBL3593825 Ki 29.0 nM
CC(C)NC(=O)N1CC[C@@H](NC2=Nc3cc(F)ccc3N(CC(F)F)c3ccc(Cl)cc32)C1 CHEMBL5274607 IC50 29.6 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 30.0 nM
Cc1[nH]nc2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 CHEMBL593490 IC50 31.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]ccc2c1 CHEMBL3580968 Ki 31.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 31.62 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3824314 Ki 32.0 nM
CC(C)c1cc(Nc2nc(N3CCC(N)CC3)nc3ccsc23)n[nH]1 CHEMBL3580953 Ki 33.0 nM
CCc1cc(Nc2nc(N3CCC(N)CC3)nc3ccsc23)n[nH]1 CHEMBL3580951 Ki 33.0 nM
CN1Cc2ccc(-c3cnc4[nH]cc(C(=O)c5ccccc5Cl)c4c3)cc2C1 CHEMBL3596931 IC50 33.0 nM
Cc1cc(C)c(N(C)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2F)cc1CO CHEMBL3935195 IC50 33.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCC5CC5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4781551 IC50 34.0 nM
CNc1ncc2cc(-c3ccc(-n4ccccc4=O)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818326 Ki 36.0 nM
COCCN(Cc1cc(F)cc2[nH]ncc12)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 CHEMBL2386715 Ki 36.8 nM
CN1CC[C@H](c2cc(Nc3ccnc(N(C)C[C@H]4CC[C@H](N)CC4)n3)n[nH]2)C1=O CHEMBL3594177 Ki 37.0 nM
COc1c(-c2cnc3[nH]cc(C(=O)c4ccc(CO)cc4Cl)c3c2)cnn1C CHEMBL3596924 IC50 37.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCC5CCOCC5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4784560 IC50 42.0 nM
COc1nn(C)cc1-c1cnc2[nH]cc(C(=O)c3ccc(COc4ccccc4)cc3Cl)c2c1 CHEMBL3596925 IC50 43.0 nM
CN(c1cccc(CO)c1)c1nc(Nc2cc(N3CCOCC3)cc(S(C)(=O)=O)c2)ncc1F CHEMBL3892617 IC50 45.0 nM
CCNC(=O)c1n[nH]c2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)ccc12 CHEMBL4748552 IC50 45.0 nM
C[C@H]1CN(C)C(=O)[C@@H]1c1cc(Nc2ccnc(N(C)C[C@H]3CC[C@H](N)CC3)n2)n[nH]1 CHEMBL3594181 Ki 46.0 nM
CCCc1cc(Nc2nc(N3CCC(N)CC3)nc3ccsc23)n[nH]1 CHEMBL3580952 Ki 48.0 nM
COc1nn(C)cc1-c1cnc2[nH]cc(C(=O)c3ccc(COc4ccccc4F)cc3Cl)c2c1 CHEMBL3596926 IC50 48.0 nM
COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1 CHEMBL1198335 IC50 48.4 nM
CCN(C[C@H]1CC[C@H](N)CC1)c1nccc(Nc2cc([C@H]3CCN(C)C3=O)[nH]n2)n1 CHEMBL3594178 Ki 49.0 nM
N[C@@H]1[C@H]2CN(c3nc(Nc4cc(C5CC5)[nH]n4)c4sccc4n3)C[C@@H]12 CHEMBL3580667 Ki 50.0 nM
CNC(=O)c1n[nH]c2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)ccc12 CHEMBL4799349 IC50 52.0 nM
CC(=O)N1CCC(n2cc(-c3cnc4[nH]cc(C(=O)c5ccc(CO)cc5Cl)c4c3)cn2)CC1 CHEMBL3596923 IC50 55.0 nM
CNc1ncc2cc(-c3ccc(N4CCN(C)C4=O)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818217 Ki 56.0 nM
COc1cc(Nc2ncc(Br)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)C(C)C1 CHEMBL2403078 IC50 61.0 nM
Cc1ccccc1C(=O)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596903 IC50 63.0 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 63.1 nM
O=C(c1cc(CO)ccc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596912 IC50 64.0 nM
CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CCCO)c2n1 CHEMBL3770806 Ki 64.0 nM
COc1cc(Nc2ncc(Br)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)[C@@H](C)C1 CHEMBL2403079 IC50 65.0 nM
COc1ccccc1-n1cc(COC(=O)C2CCn3c(C(=O)c4ccccc4)ccc32)nn1 CHEMBL4067898 IC50 65.0 nM
CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CC3CCNC(=O)C3)c2n1 CHEMBL3769981 Ki 66.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCCO)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4750093 IC50 66.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC(F)(F)C3)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3822836 Ki 68.0 nM
COCCNC(=O)c1n[nH]c2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)ccc12 CHEMBL4764182 IC50 71.0 nM
COc1cc(Nc2ncc(Br)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)[C@H](C)C1 CHEMBL2403080 IC50 72.0 nM
Clc1ccccc1Cc1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596898 IC50 83.0 nM
O=C(c1ccc(COc2ccccc2)cc1)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596910 IC50 84.0 nM
C[C@H](Nc1nccc(Nc2cc([C@@H]3C[C@@H]3F)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3823056 Ki 84.0 nM
Cc1cccc(Cl)c1C(=O)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596911 IC50 88.0 nM
CNc1ncc2cc(-c3ccc(N4CCCC4=O)cc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818571 Ki 89.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCc5ccccc5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4764341 IC50 92.0 nM
COc1cc(Nc2ncc(Cl)c(-c3cc(F)cc(CC#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2403056 IC50 98.0 nM
CC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)CC1 CHEMBL3580948 Ki 100.0 nM
Cc1ccc(CO)cc1N(C)c1ccnc(Nc2cc(N3CCOCC3)cc(S(C)(=O)=O)c2)n1 CHEMBL1762546 IC50 100.0 nM
COc1cc(Nc2ncc(Cl)c(-c3cc(Cl)cc(CC#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2403057 IC50 103.0 nM
COc1cc(Nc2ncc(Cl)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2312140 IC50 110.0 nM
CN1CC[C@H](c2cc(Nc3ccnc(NC[C@H]4CC[C@H](N)CC4)n3)n[nH]2)C1=O CHEMBL3594176 Ki 111.0 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3[nH]cnc3c2)n1 CHEMBL3580969 Ki 117.0 nM
NC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3occc3n2)CC1 CHEMBL3580956 Ki 119.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1nc2cc[nH]c2cc1Cl CHEMBL3823258 Ki 119.0 nM
O=C(c1ccccc1F)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596904 IC50 120.0 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3[nH]ccc3n2)n1 CHEMBL3824075 Ki 120.0 nM
C[C@H](Nc1nccc(Nc2cc([C@H]3C[C@H]3F)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3823469 Ki 120.0 nM
COc1cc(Nc2ncc(Cl)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)C(C)C1 CHEMBL2403077 IC50 126.0 nM
COc1nn(C)cc1-c1cnc2[nH]cc(C(=O)c3ccc(COc4cccnc4)cc3Cl)c2c1 CHEMBL3596928 IC50 130.0 nM
CCN1c2ccc(F)cc2N=C(N[C@H]2CCN(C(=O)OC(C)(C)C)C2)c2cc(Cl)ccc21 CHEMBL3609370 Kd 130.0 nM
Nc1ccc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cn1 CHEMBL3580964 Ki 138.0 nM
COc1nn(C)cc1-c1cnc2[nH]cc(C(=O)c3ccc(CCO)cc3Cl)c2c1 CHEMBL3596929 IC50 140.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NC5CCN(C)CC5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4755754 IC50 143.0 nM
N[C@H]1CC[C@H](Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580961 Ki 157.0 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 158.49 nM
CNC(=O)c1n[nH]c2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)ccc12 CHEMBL4790872 IC50 159.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NC1CCN(c2ncnc3[nH]ncc23)CC1 CHEMBL4780410 IC50 170.0 nM
Fc1c(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)ccc2[nH]cnc12 CHEMBL3580973 Ki 179.0 nM
Cc1cc(Nc2nc(N3CCC(N)CC3)nc3ccsc23)n[nH]1 CHEMBL3580950 Ki 179.0 nM
COCc1ccc(C)c(N(C)c2nc(Nc3cc(N4CCOCC4)cc(S(C)(=O)=O)c3)ncc2F)c1 CHEMBL3969873 IC50 189.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 210.0 nM
O=C(CCN1CCOCC1)Nc1ccc2c(c1)/C(=C\c1n[nH]c3ccccc13)C(=O)N2 CHEMBL4777980 IC50 220.0 nM
COc1cc(Nc2ncc(Cl)c(-c3cc(Cl)cc(C#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2403058 IC50 227.0 nM
Cc1cccc(-c2ccc(-c3ccc4c(C(=O)NCC5CC5)n[nH]c4c3)c(Cl)c2)n1 CHEMBL4789576 IC50 229.0 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCCCCCCCCNC(=O)N4CC[C@H](NC5=Nc6cc(F)ccc6N(CC(F)F)c6ccc(Cl)cc65)C4)c3C2=O)C1=O CHEMBL5281068 IC50 233.0 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCC2CCNCC2)n1 CHEMBL3580960 Ki 245.0 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCN(C)CCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1993166 pKi 251.19 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 260.0 nM
O=C(c1ccc(Cl)cc1)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596908 IC50 260.0 nM
CC(=O)N1CCc2cc(-c3cnc4[nH]cc(C(=O)c5ccccc5Cl)c4c3)ccc2C1 CHEMBL3597012 IC50 270.0 nM
NC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CC1 CHEMBL4076708 Ki 288.0 nM
CCOC(=O)c1cc(Nc2ncc(Cl)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2403070 IC50 289.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 316.23 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 316.23 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 316.23 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 316.23 nM
CCN1c2ccc(F)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21 CHEMBL3609330 IC50 323.0 nM
CNC(=O)c1n[nH]c2cc(-c3ccc(-n4ccccc4=O)cc3Cl)ccc12 CHEMBL4763427 IC50 330.0 nM
CNc1ccc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cn1 CHEMBL3580965 Ki 346.0 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3nccn3c2)n1 CHEMBL3824324 Ki 360.0 nM
CN1CCCC(c2cc(Nc3ccnc(N(C)C[C@H]4CC[C@H](N)CC4)n3)n[nH]2)C1=O CHEMBL3594179 Ki 362.0 nM
CC[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CCN1 CHEMBL4076860 Ki 368.0 nM
Cc1cncc(-c2ccc(-c3cc4cncnc4n(C[C@H]4CC[C@H](N)CC4)c3=O)c(Cl)c2)n1 CHEMBL3819371 Ki 372.0 nM
CC(=O)N(C)Cc1cc(Nc2ccnc(N(C)Cc3ccc4[nH]cnc4c3Cl)n2)n[nH]1 CHEMBL3594173 Ki 373.0 nM
CNc1ncc2cc(-c3ccccc3Cl)c(=O)n(CCCN)c2n1 CHEMBL3818088 Ki 382.0 nM
C[C@H]1CNCCN1C(=O)c1nc(Nc2cc(C3CC3)[nH]n2)c2cc(Cl)ccc2n1 CHEMBL4063425 Ki 383.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 398.11 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1991728 pKi 398.11 nM
O=C(c1ccccc1)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596902 IC50 400.0 nM
C[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3ccc(Cl)cc3n2)CCN1 CHEMBL4081464 Ki 401.0 nM
CS(=O)(=O)c1ccc(C(=O)c2c[nH]c3ncc(-c4cnn(C5CCNCC5)c4)cc23)c(Cl)c1 CHEMBL3596918 IC50 440.0 nM
NC1CCN(c2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580957 Ki 454.0 nM
Clc1ccccc1-c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596900 IC50 460.0 nM
COc1cc(C#N)cc(-c2nc(Nc3ccc(N4CCN(C)CC4)c(OC)c3)ncc2Cl)c1 CHEMBL2403059 IC50 487.0 nM
COc1ccccc1C(=O)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596906 IC50 490.0 nM
COCC[n+]1c2c(n(Cc3cnccn3)c1C)C(=O)c1ccccc1C2=O CHEMBL2105734 IC50 500.0 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1 CHEMBL1090360 pKi 501.19 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 501.19 nM
C[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(F)ccc3n2)CCN1 CHEMBL4059493 Ki 503.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(-c4cccc(CC#N)c4)n3)cc2F)CC1 CHEMBL2403065 IC50 548.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 Kd 550.0 nM
CN1CC[C@@H](c2cc(Nc3ccnc(N(C)Cc4ccc5[nH]cnc5c4Cl)n3)n[nH]2)C1=O CHEMBL3594174 Ki 552.0 nM
O=C(Nc1ccccc1Cl)NC1CCN(c2ncnc3[nH]ncc23)CC1 CHEMBL4798596 IC50 560.0 nM
NC1CCN(c2cccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580958 Ki 561.0 nM
CNc1ncc2cc(-c3ccc(-c4ncccc4F)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 CHEMBL5090394 IC50 580.0 nM
Cn1cnc2ccc(CNc3nccc(Nc4cc(C5CC5)[nH]n4)n3)cc21 CHEMBL3580971 Ki 584.0 nM
O=C(NCC1CC1)c1n[nH]c2cc(-c3ccc(-n4ccccc4=O)cc3Cl)ccc12 CHEMBL4782048 IC50 590.0 nM
Cn1cnc2cc(CNc3nccc(Nc4cc(C5CC5)[nH]n4)n3)ccc21 CHEMBL3580970 Ki 607.0 nM
NC(=O)c1ccc(C(=O)c2c[nH]c3ncc(-c4cnn(C5CCNCC5)c4)cc23)c(Cl)c1 CHEMBL3596917 IC50 630.0 nM
O=C(c1ccc(CO)cc1)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596909 IC50 630.0 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 630.96 nM
Cc1cnc(-c2cc(Nc3ncc(Cl)c(-c4cccc(CC#N)c4)n3)ccc2N2CCN(C)CC2)o1 CHEMBL2403075 IC50 636.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 650.0 nM
N#Cc1ccc(Cl)c(C(=O)c2c[nH]c3ncc(-c4cnn(C5CCNCC5)c4)cc23)c1 CHEMBL3596913 IC50 650.0 nM
NC1CCN(c2nc(Nc3cc(-c4ccccc4)[nH]n3)c3sccc3n2)CC1 CHEMBL3580955 Ki 660.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(-c4cccc(CC#N)c4)n3)cc2O)CC1 CHEMBL2403066 IC50 674.0 nM
C[C@@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]ccc2n1 CHEMBL3822986 IC50 685.0 nM
C[C@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CCN1 CHEMBL4077032 Ki 690.0 nM
N#Cc1ccccc1C(=O)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596905 IC50 740.0 nM
Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NC5CCOCC5)n[nH]c4c3)c(Cl)c2)c1=O CHEMBL4794451 IC50 744.0 nM
Cc1cncc(-c2ccc(-c3ccc4c(C(=O)NCC5CC5)n[nH]c4c3)c(Cl)c2)n1 CHEMBL4783727 IC50 777.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(-c4cccc(CC#N)c4)n3)cc2C#N)CC1 CHEMBL2403071 IC50 780.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 794.33 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 794.33 nM
O=C(CCN1CCOCC1)Nc1ccc2c(c1)/C(=C\c1c[nH]c3ccccc13)C(=O)N2 CHEMBL4779121 IC50 830.0 nM
Cn1ccc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5089164 IC50 859.5 nM
CN1CCN(C2=Nc3cc(F)ccc3N(C)c3ccc(Cl)cc32)CC1 CHEMBL3609329 IC50 900.0 nM
CNc1ncc2cc(-c3ccc(-n4ccc(C)cc4=O)cc3Cl)c(=O)n(C[C@H]3CNCCO3)c2n1 CHEMBL3818261 Ki 943.0 nM
CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3C3CC3)c(=O)n(C[C@@H]3CNCCO3)c2n1 CHEMBL3819633 Ki 950.0 nM
CCOc1cc(Nc2ncc(Cl)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2403067 IC50 957.0 nM
COc1cc(Nc2ncc(Cl)c(-c3cccc(C(C)(C)C#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2403060 IC50 985.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 1000.0 nM
CO[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3[C@H](O)[C@@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@H](O[C@H]4[C@H](O[C@H]5CC[C@]6(C)[C@@H]7CCC89C(=O)O[C@@](C)(CCCC(C)C)[C@H]8[C@@H](OC(C)=O)C[C@@]9(C)C7=CC[C@H]6C5(C)C)OC[C@@H](OS(=O)(=O)[O-])[C@@H]4O)O[C@@H]3C)OC[C@H]2O)O[C@H](CO)[C@H]1O CHEMBL4293583 IC50 1000.0 nM
Oc1ccc2ccccc2c1SSc1c(O)ccc2ccccc12 CHEMBL472940 IC50 1000.0 nM