CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(Cl)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1 CHEMBL3669583 EC50 0.94 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C(C)(C)C(F)(F)F)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064631 EC50 1.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 IC50 1.3 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 1.585 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3674597 Ki 1.6 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)c2ccsc2n1 CHEMBL3674593 Ki 1.9 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(n[nH]c2Nc2ccnc(C#N)n2)C1(C)C)c1ccccc1 CHEMBL3674594 EC50 1.9 nM
N[C@@H]1[C@H]2CN(c3nc(Nc4cc(C5CC5)[nH]n4)c4sccc4n3)C[C@@H]12 CHEMBL3580667 Ki 2.0 nM
CCOc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 CHEMBL3669628 EC50 2.4 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(n[nH]c2Nc2ncnc3c2ncn3C)C1(C)C)c1ccccc1 CHEMBL3669627 EC50 2.5 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3cccc(Cl)c3)nc3[nH]ccc23)CC1 CHEMBL5180027 IC50 2.7 nM
CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4cc(NCc5ccc(-c6ccccn6)cc5)ccc4[nH]3)c2c1)c1ccccc1 CHEMBL2064556 Ki 2.8 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(n[nH]c2Nc2nc(C#N)nc3ccccc23)C1(C)C)c1ccccc1 CHEMBL3669632 Ki 3.0 nM
COCCNc1nc2ccc(C#CC3(O)CCCCC3)cc2n1-c1ccnc(N)n1 CHEMBL3128042 Ki 3.3 nM
COCCNc1nc2ccc(C#CC3(O)CCCCC3)cc2n1-c1ncnc(N)n1 CHEMBL5191406 Ki 3.3 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3664542 Ki 3.5 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(n[nH]c2Nc2nc(C#N)nc3ccccc23)C1(C)C)c1ccccc1 CHEMBL3674598 Ki 3.6 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C(C)(C)C)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064628 EC50 4.0 nM
N[C@H]1CC[C@@H](CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580963 Ki 4.0 nM
CCOc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 CHEMBL3674596 EC50 4.4 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 5.0 nM
Cc1cc2c(Nc3[nH]nc4c3CN(C(=O)O[C@H](CN(C)C)c3ccccc3)C4(C)C)ncnc2s1 CHEMBL3674595 Ki 5.2 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(n[nH]c2Nc2ncnc3sccc23)C1(C)C)c1ccccc1 CHEMBL3674599 Ki 5.2 nM
CCNc1nc2ccc(C#C[C@@](C)(O)c3cc(C)on3)cc2n1-c1ncnc(N)n1 CHEMBL3355023 IC50 5.3 nM
Cc1cc(Nc2cc(Cc3ccccc3)nc(NC3CCNCC3)n2)n[nH]1 CHEMBL5175418 IC50 5.9 nM
CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)c1ccccc1 CHEMBL2064555 Ki 6.0 nM
CC[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CCN1 CHEMBL4076860 Ki 6.0 nM
NC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CC1 CHEMBL4076708 Kd 6.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 6.0 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(n[nH]c2Nc2ncnc3ccsc23)C1(C)C)c1ccccc1 CHEMBL3669636 Ki 6.7 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C3(C(F)(F)F)CC3)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064632 EC50 7.0 nM
C[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3ccc(Cl)cc3n2)CCN1 CHEMBL4081464 Ki 7.0 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2ccsc2n1 CHEMBL3669607 Ki 7.2 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 7.943 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 7.943 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(n[nH]c2Nc2ccnc(C(F)(F)F)n2)C1(C)C)c1ccccc1 CHEMBL3674600 Ki 8.3 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccc(F)cc3)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064562 EC50 9.0 nM
C[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CCN1 CHEMBL4097816 Ki 9.0 nM
N[C@H](CNC(=O)c1nc(Nc2n[nH]c3ccccc23)c2cc(Cl)ccc2n1)Cc1ccccc1 CHEMBL5429021 IC50 9.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 IC50 10.0 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 10.0 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 10.0 nM
CC(C)[C@@H](N)CNC(=O)c1nc(Nc2n[nH]c3ccccc23)c2cc(Cl)ccc2n1 CHEMBL5411182 IC50 10.0 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccccc3)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064561 EC50 11.0 nM
CN1CCN(C(=O)N2Cc3c(n[nH]c3Nc3nc(Cl)nc4ccsc34)C2(C)C)[C@@H](Cc2ccccc2)C1 CHEMBL3669580 Ki 11.0 nM
C[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Br)ccc3n2)CCN1 CHEMBL4089338 Ki 11.0 nM
N[C@@H](CNC(=O)c1nc(Nc2n[nH]c3ccccc23)c2cc(Cl)ccc2n1)Cc1ccccc1 CHEMBL5400697 IC50 11.0 nM
NC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)CC1 CHEMBL3580949 Ki 12.0 nM
N[C@@H](CNC(=O)c1nc(Nc2n[nH]c3ccccc23)c2cc(Cl)ccc2n1)c1ccccc1 CHEMBL5395115 IC50 13.0 nM
CC1(C)c2n[nH]c(Nc3nc(Cl)nc4ccsc34)c2CN1C(=O)NC1CC1c1ccccc1 CHEMBL3669579 Ki 14.0 nM
COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1 CHEMBL1198335 IC50 14.9 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064564 EC50 15.0 nM
Cc1cc2c(Nc3[nH]nc4c3CN(C(=O)N[C@H](CN(C)C)c3ccccc3)C4(C)C)ncnc2s1 CHEMBL3669631 Ki 15.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 15.85 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C3CCCO3)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064629 EC50 16.0 nM
CC1(C)c2n[nH]c(Nc3ncnc4sccc34)c2CN1C(=O)N[C@@H]1C[C@H]1c1ccccc1 CHEMBL3669616 Ki 16.0 nM
O=C(c1nc(Nc2cc(C3CC3)[nH]n2)c2cc(Cl)ccc2n1)N1CCNCC1 CHEMBL4064068 Ki 16.0 nM
C[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(F)ccc3n2)CCN1 CHEMBL4059493 Ki 16.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C/c1cnc[nH]1 CHEMBL4078441 IC50 16.0 nM
CC(C)[C@H](N)CNC(=O)c1nc(Nc2n[nH]c3ccccc23)c2cc(Cl)ccc2n1 CHEMBL5414332 IC50 16.0 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2cc[nH]c12 CHEMBL3416026 Kd 17.0 nM
C[C@@H]1CNCCN1C(=O)c1nc(Nc2cc(C3CC3)[nH]n2)c2cc(Cl)ccc2n1 CHEMBL4090101 Ki 17.0 nM
C[C@@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)CCN1 CHEMBL4101547 Ki 17.0 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C3CCCCO3)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064630 EC50 18.0 nM
CC1(C)c2n[nH]c(Nc3nc(C#N)nc4ccccc34)c2CN1C(=O)N[C@@H]1C[C@H]1c1ccccc1 CHEMBL3669614 Ki 18.0 nM
CC1(C)c2n[nH]c(Nc3ncnc4ccsc34)c2CN1C(=O)N[C@@H]1C[C@H]1c1ccccc1 CHEMBL3669623 Ki 18.0 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(n[nH]c2Nc2ncnc3sccc23)C1(C)C)c1ccccc1 CHEMBL3669630 EC50 19.0 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 19.95 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 19.95 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(n[nH]c2Nc2ncncc2F)C1(C)C)c1ccccc1 CHEMBL3669635 EC50 20.0 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(n[nH]c2Nc2ncncc2F)C1(C)C)c1ccccc1 CHEMBL3674604 EC50 20.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3cccc(Cl)c3)nc3[nH]ccc23)CC1 CHEMBL5183512 IC50 20.2 nM
CN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccc4)n[nH]c3C2(C)C)C(c2ccccc2)C1 CHEMBL2064560 EC50 21.0 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)cc(N2CCOCC2)n1 CHEMBL3669608 Ki 21.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C/c1ccc[nH]1 CHEMBL4104099 pIC50 21.88 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 24.0 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3669615 Ki 24.0 nM
N[C@H](CNC(=O)c1nc(Nc2n[nH]c3ccccc23)c2cc(Cl)ccc2n1)c1ccccc1 CHEMBL5401120 IC50 24.0 nM
CC1(C)c2n[nH]c(Nc3nc(C(F)(F)F)nc4ccsc34)c2CN1C(=O)N[C@@H]1C[C@H]1c1ccccc1 CHEMBL3669619 Ki 25.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 25.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C(\c1ccccc1)c1ncc[nH]1 CHEMBL4160587 IC50 25.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 25.12 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 25.12 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 25.12 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 25.12 nM
C[C@H]1CNCCN1C(=O)c1nc(Nc2cc(C3CC3)[nH]n2)c2cc(Cl)ccc2n1 CHEMBL4063425 Ki 26.0 nM
Cc1cc(C)c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)[nH]1 CHEMBL4088781 IC50 27.0 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064565 EC50 28.0 nM
C[C@H]1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CCN1 CHEMBL4077032 Ki 28.0 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccccc3)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064558 Ki 30.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 31.62 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 31.62 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 31.62 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 31.62 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 31.62 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 31.62 nM
Cc1cc([C@](C)(O)C#Cc2ccc3nc(C)n(-c4ncnc(N)n4)c3c2)no1 CHEMBL3128052 Ki 32.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C(/c1ncc[nH]1)c1ccccc1Cl CHEMBL4164650 IC50 32.0 nM
Clc1ccc2nc(NCCc3c[nH]c4ccccc34)nc(Nc3ccc4[nH]ncc4c3)c2c1 CHEMBL4087295 IC50 33.0 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@H]2c2ccccc2)C3(C)C)c2ccccc2n1 CHEMBL3674609 Ki 34.0 nM
CNc1nc2ccc(C#C[C@@](C)(O)c3cc(C)on3)cc2n1-c1ncnc(N)n1 CHEMBL3355024 IC50 35.5 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccccc3F)n[nH]c2C1(C)C)c1ccccc1 CHEMBL2064563 EC50 36.0 nM
COc1ccc2nc(C(=O)N3CCN[C@H](C)C3)nc(Nc3cc(C4CC4)[nH]n3)c2c1 CHEMBL4068155 Ki 36.0 nM
N[C@H]1CC[C@H](CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580962 Ki 38.0 nM
CC1(C)c2n[nH]c(Nc3nc(Cl)nc4ccccc34)c2CN1C(=O)NC1CC1c1ccccc1 CHEMBL3669589 Ki 38.0 nM
COc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 CHEMBL3674603 Ki 39.0 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 39.81 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 39.81 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 39.81 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(n[nH]c2Nc2ccnc(C#N)n2)C1(C)C)c1ccccc1 CHEMBL3669629 Ki 40.0 nM
CC1(C)c2n[nH]c(Nc3ncnc4ccsc34)c2CN1C(=O)N[C@H]1CC1c1ccccc1 CHEMBL3674607 Ki 41.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]ccc2c1 CHEMBL3580968 Ki 42.0 nM
Cc1cc(Nc2nc(N3CCC(N)CC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4091048 Kd 43.0 nM
NC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3occc3n2)CC1 CHEMBL3580956 Ki 45.0 nM
Cc1cc(Nc2nc(C(=O)N3CCNCC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4093999 Ki 45.0 nM
CC1(C)c2n[nH]c(Nc3ccnc(C#N)n3)c2CN1C(=O)N[C@@H]1C[C@H]1c1ccccc1 CHEMBL3639684 Ki 47.0 nM
CC1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)CC1 CHEMBL3580948 Ki 49.0 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 50.12 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 50.12 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 50.12 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 50.12 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 50.12 nM
Clc1cccc(Nc2nc(NC3CCNCC3)c3cc[nH]c3n2)c1 CHEMBL5184137 IC50 50.3 nM
Cc1cc(Nc2nc(C(=O)N3CCN[C@H](C)C3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4079783 Ki 51.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 53.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccc(F)cc3)cc2/C1=C/c1ccc[nH]1 CHEMBL4073938 IC50 54.0 nM
CC1(C)c2n[nH]c(Nc3nc(C4CC4)nc4ccccc34)c2CN1C(=O)NC1C[C@H]1c1ccccc1 CHEMBL3674611 Ki 55.0 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(n[nH]c2Nc2ncnc3ccoc23)C1(C)C)c1ccccc1 CHEMBL3674608 Ki 58.0 nM
CCNc1nc2ccc(C#CC(C)(C)O)cc2n1-c1ncnc(N)n1 CHEMBL3128055 Ki 60.0 nM
COc1ccc(/C(=C2/C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)c2ncc[nH]2)cc1 CHEMBL4172279 IC50 61.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C(/c1ncc[nH]1)c1ccccc1F CHEMBL4175282 IC50 63.0 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 63.1 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 63.1 nM
CN1CCN(C(=O)N2Cc3c(NC(=O)c4cccc(Oc5ccccc5)c4)n[nH]c3C2(C)C)[C@@H](Cc2ccccc2)C1 CHEMBL2064557 Ki 64.0 nM
CC1(C)c2[nH]nc(Nc3ncnc4ccoc34)c2CN1C(=O)N[C@H]1C[C@@H]1c1ccccc1 CHEMBL3664512 Ki 67.0 nM
Cc1ccccc1/C(=C1/C(=O)Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc21)c1ncc[nH]1 CHEMBL4171839 IC50 67.0 nM
Cc1nccc(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 CHEMBL3669633 EC50 67.13 nM
Cc1nc2ccc(C#CC3(O)CCCCC3)cc2n1-c1ncnc(N)n1 CHEMBL3128050 Ki 68.0 nM
Cc1ncnc(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)c1F CHEMBL3674601 EC50 69.0 nM
Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1 CHEMBL3979920 IC50 76.0 nM
COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(N2CCC[C@H]2CO)n1 CHEMBL3669593 Ki 76.0 nM
CC(C)c1cc(Nc2nc(N3CCC(N)CC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4060217 Ki 77.0 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 79.43 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 79.43 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 79.43 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 79.43 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 79.43 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCC2CCNCC2)n1 CHEMBL3580960 Ki 80.0 nM
CC1(C)c2n[nH]c(Nc3ccnc(C(F)(F)F)n3)c2CN1C(=O)NC1C[C@@H]1c1ccccc1 CHEMBL3669606 Ki 80.0 nM
Cc1csc2c(Nc3[nH]nc4c3CN(C(=O)N3C[C@@H]5CCCN5C[C@@H]3C)C4(C)C)ncnc12 CHEMBL3674605 Ki 84.0 nM
CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4ccsc34)n[nH]c2C1(C)C)c1ccccc1 CHEMBL3669582 EC50 87.0 nM
CCCOc1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1 CHEMBL3669584 Ki 87.0 nM
CCc1ncc(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)[nH]1 CHEMBL4174013 IC50 89.0 nM
CN(C)c1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1 CHEMBL3669592 Ki 90.0 nM
COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(N2CCCC2C#N)n1 CHEMBL3674612 Ki 90.0 nM
Clc1ccc2nc(Nc3ccc4[nH]ncc4c3)nc(NCCc3c[nH]c4ccccc34)c2c1 CHEMBL4089425 IC50 93.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 96.0 nM
Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)cc(N(C)C)n1 CHEMBL3669612 Ki 96.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3[nH]ncc23)n[nH]1 CHEMBL5209160 IC50 96.1 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 100.0 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 100.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 100.0 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 100.0 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 100.0 nM
CN(C)c1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1992363 pKi 100.0 nM
N[C@H]1CC[C@H](Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580961 Ki 100.0 nM
CC1(C)c2n[nH]c(Nc3ncnc4ccccc34)c2CN1C(=O)NC1C[C@H]1c1ccccc1 CHEMBL3674610 Ki 100.0 nM
Nc1ccc(/C=C/C(=O)NCc2cc3cc(-c4ccc(C(=O)N5CCC(F)(F)CC5)cc4)cc(-c4ccc(F)cc4)c3o2)cn1 CHEMBL4297467 IC50 100.0 nM
Nc1ccc(/C=C/C(=O)NCc2cc3cc(-c4ccc(C(=O)N5CCC(F)(F)CC5)cn4)cc(-c4ccc(F)cc4)c3o2)cn1 CHEMBL5438274 IC50 100.0 nM
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]cnc2c1 CHEMBL3580972 Ki 106.0 nM
CC1(C)c2n[nH]c(Nc3cc(Cl)nc(Cl)n3)c2CN1C(=O)NC1C[C@@H]1c1ccccc1 CHEMBL3669581 Ki 110.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 110.0 nM
CC(C)(O)C#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 CHEMBL2334586 IC50 110.0 nM
CC1CN(C(=O)c2nc(Nc3cc(C4CC4)[nH]n3)c3cc(Cl)ccc3n2)CC(C)N1 CHEMBL4090268 Ki 114.0 nM
Cc1ncc(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)[nH]1 CHEMBL4171374 IC50 114.0 nM
COc1cccc(/C(=C2/C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)c2ncc[nH]2)c1 CHEMBL4168084 IC50 115.0 nM
Cc1cc(Nc2nc(C(=O)N3CC(C)NC(C)C3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4062257 Ki 119.0 nM
CC(C)(O)C#Cc1ccc2cnn(-c3ccnc(N)n3)c2c1 CHEMBL3128057 Ki 120.0 nM
COc1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1 CHEMBL3669587 Ki 120.0 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 125.89 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 125.89 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 125.89 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 125.89 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 125.89 nM
CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL23327 IC50 130.0 nM
CC(C)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5407680 IC50 131.0 nM
Cc1nc(/C(=C2\C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)c2ccccc2)[nH]c1C CHEMBL4162970 IC50 139.0 nM
COCCNc1nc2ccc(C#CC(C)(C)O)cc2n1-c1ccnc(N)n1 CHEMBL3128041 Ki 140.0 nM
CN(C)c1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(N2CCC[C@H]2CO)n1 CHEMBL3669599 Ki 140.0 nM
CCc1cc(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)ncn1 CHEMBL3669624 Ki 140.0 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3[nH]ccc3c2)n1 CHEMBL3580967 Ki 144.0 nM
Cc1cc(Nc2nc(C(=O)N3CCNC[C@H]3C)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4069022 Ki 151.0 nM
Cn1cnc(Nc2nc(N3CCC(N)CC3)nc3ccc(Cl)cc23)c1 CHEMBL4084054 Kd 156.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 158.49 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 158.49 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 158.49 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccc(F)cc1 CHEMBL1966204 pKi 158.49 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 158.49 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 158.49 nM
Cc1csc2c(Nc3[nH]nc4c3CN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)C4(C)C)ncnc12 CHEMBL3669622 Ki 160.0 nM
CC(=O)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5427137 IC50 161.0 nM
Cc1c[nH]c(/C(=C2\C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)c2ccccc2)n1 CHEMBL4177047 IC50 162.0 nM
Fc1cccc(Nc2nc(NC3CCNCC3)c3cc[nH]c3n2)c1 CHEMBL5202902 IC50 164.5 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 166.0 nM
COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(S(=O)(=O)Cc3cccc([N+](=O)[O-])c3F)cc2F)nc1N1CCOCC1 CHEMBL5185225 IC50 168.0 nM
Clc1ccccc1-c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596900 IC50 170.0 nM
COc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 CHEMBL3669634 Ki 170.0 nM
Brc1ccc2nc(NCCc3c[nH]c4ccccc34)nc(Nc3ccc4[nH]ncc4c3)c2c1 CHEMBL4079417 IC50 177.0 nM
Cc1nc2ccc(C#C[C@@]3(O)C[C@@H]4CC[C@H]3C4)cc2n1-c1ncnc(N)n1 CHEMBL3128051 Ki 190.0 nM
COc1nc(Nc2n[nH]c3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(N2CCCC2)n1 CHEMBL3669596 Ki 190.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3Cl)cc2/C1=C/c1ccc[nH]1 CHEMBL4100711 IC50 199.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 199.53 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 199.53 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 199.53 nM
CC1(C)c2n[nH]c(Nc3cccc(C(F)(F)F)n3)c2CN1C(=O)NC1C[C@@H]1c1ccccc1 CHEMBL3669603 Ki 200.0 nM
Cc1cc(Nc2nc(C(=O)N3CCNC[C@@H]3C)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4095362 Ki 218.0 nM
Cc1cc(C(F)(F)F)cc(Nc2n[nH]c3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)n1 CHEMBL3669602 Ki 220.0 nM
N[C@H]1CCCN(c2nc(Nc3cccc(Cl)c3)nc3[nH]ccc23)C1 CHEMBL5170532 IC50 229.0 nM
N[C@@H]1CCCN(c2nc(Nc3cccc(Cl)c3)nc3[nH]ccc23)C1 CHEMBL5183475 IC50 229.0 nM
Cc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)n1 CHEMBL3669618 Ki 230.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCNCC2)n[nH]1 CHEMBL5188129 IC50 231.1 nM
COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(N2CCC[C@H]2C(N)=O)n1 CHEMBL3669597 Ki 240.0 nM
Cc1ncnc(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c1F CHEMBL3669626 Ki 240.0 nM
O=C(Nc1cncnc1)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4ccc(CN5CCOCC5)cc4)cc23)c1 CHEMBL5401007 IC50 244.0 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 251.19 nM
N#Cc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1990162 pKi 251.19 nM
NC1CCN(c2nc(Nc3cc(-c4ccccc4)[nH]n3)c3cc(Cl)ccc3n2)CC1 CHEMBL4093805 Ki 256.0 nM
Cc1cc2c(Nc3[nH]nc4c3CN(C(=O)N[C@@H]3C[C@H]3c3ccccc3)C4(C)C)ncnc2s1 CHEMBL3669609 Ki 260.0 nM
CC1(C)c2n[nH]c(Nc3nc(Cl)nc(Cl)n3)c2CN1C(=O)NC1CC1c1ccccc1 CHEMBL3669586 Ki 270.0 nM
COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(OC)n1 CHEMBL3669591 Ki 270.0 nM
CC1(C)c2n[nH]c(Nc3nccc(C(F)(F)F)n3)c2CN1C(=O)NC1C[C@@H]1c1ccccc1 CHEMBL3669604 Ki 270.0 nM
CCOc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)n1 CHEMBL3669611 Ki 270.0 nM
CC(C)c1ncc(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)[nH]1 CHEMBL4166094 IC50 270.0 nM
CN(Cc1ccc2[nH]cnc2c1Cl)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 CHEMBL3580975 Ki 272.0 nM
Cc1cc(Nc2nc(NC3CCNCC3)nc3[nH]ncc23)n[nH]1 CHEMBL5186873 IC50 273.4 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C/c1ncc[nH]1 CHEMBL4096476 IC50 281.0 nM
NC1CCN(c2nccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580957 Ki 283.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccnc5)c4)c3c2)c1 CHEMBL5431124 IC50 297.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)Cc3ccccc3)cc2/C1=C/c1ccc[nH]1 CHEMBL4073138 IC50 304.0 nM
Cc1cc(Nc2nc(C(=O)N3CCN[C@@H](C)C3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4059904 Ki 306.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 316.23 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 316.23 nM
COc1ccc(-n2ccc3cnc(Nc4cc(OC)c(OC)c(OC)c4)nc32)cc1 CHEMBL1975927 pKi 316.23 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 316.23 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C(\c1ccccc1)c1nc2ccccc2[nH]1 CHEMBL4173672 IC50 323.0 nM
Cc1cc(Nc2nc(C(=O)NC3CCNCC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4076937 Ki 325.0 nM
CN(C)C[C@@H](OC(=O)N1Cc2c(n[nH]c2Nc2ncnc3c2ncn3C)C1(C)C)c1ccccc1 CHEMBL3674602 Ki 330.0 nM
COc1nc(Nc2n[nH]c3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(N2CC2C)n1 CHEMBL3669595 Ki 340.0 nM
CN1CC[C@H](c2cc(Nc3ccnc(N(C)C[C@H]4CC[C@H](N)CC4)n3)n[nH]2)C1=O CHEMBL3594177 Ki 344.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 344.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cncnc5)c4)c3c2)c1 CHEMBL5421662 IC50 345.0 nM
Cc1cc(Nc2nc(C(=O)N3CCC(N)CC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4069074 Ki 354.0 nM
Clc1ccc2c(Nc3ccc4[nH]ncc4c3)nc(NCCc3c[nH]c4ccccc34)nc2c1 CHEMBL4103678 IC50 360.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C3(C)C)c2ccsc2n1 CHEMBL3669620 Ki 370.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C/c1ccn[nH]1 CHEMBL4067539 IC50 379.0 nM
Cc1cc(Nc2nc(NCc3ccccc3F)nc3[nH]ncc23)n[nH]1 CHEMBL5185324 IC50 389.2 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccc(Cl)cc3)cc2/C1=C/c1ccc[nH]1 CHEMBL4079852 IC50 391.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3)nc3[nH]ncc23)n[nH]1 CHEMBL5200865 IC50 395.1 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 398.11 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 398.11 nM
CN(C)CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1995712 pKi 398.11 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 398.11 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 398.11 nM
c1ccc2c(Nc3ccc4[nH]ncc4c3)nc(NCCc3c[nH]c4ccccc34)nc2c1 CHEMBL4104844 IC50 406.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C(/c1ncc[nH]1)c1ccc(Cl)cc1Cl CHEMBL4176335 IC50 410.0 nM
COc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)n1 CHEMBL3669617 Ki 450.0 nM
O=C(Nc1n[nH]c2cc(C(=O)N[C@H](CN3CCCC3)c3ccccc3)sc12)c1ccc(N2CCOCC2)cc1 CHEMBL1258913 IC50 455.0 nM
Clc1c(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)ccc2[nH]cnc12 CHEMBL3580974 Ki 455.0 nM
Cc1cc(Nc2nc(NCc3cccc(F)c3)nc3[nH]ncc23)n[nH]1 CHEMBL5199896 IC50 458.2 nM
COc1ccc2c(Nc3ccc4[nH]ncc4c3)nc(NCCc3c[nH]c4ccccc34)nc2c1 CHEMBL4065875 IC50 483.0 nM
Cc1nc2ccc(C#CC(C)(C)O)cc2n1-c1ncnc(N)n1 CHEMBL3128044 Ki 500.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Ki 500.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 501.19 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 501.19 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 501.19 nM
CCN(CC)CCNC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1970290 pKi 501.19 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 501.19 nM
COc1cc(-c2nn(C3CCC(N4CCN(C(C)=O)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1970879 pKi 501.19 nM
CCOc1ccccc1-c1cccc(-c2n[nH]c3nc(O)cc(C)c23)c1 CHEMBL1983070 pKi 501.19 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3sccc3n2)cc1 CHEMBL2007559 pKi 501.19 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 501.19 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3[nH]ccc3n2)n1 CHEMBL3824075 Ki 505.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]nc(-c5cc(F)cc(NC(=O)Nc6cncnc6)c5)c4c3)cc2)CC1 CHEMBL5399402 IC50 508.0 nM
CN(C)C[C@H](c1ccccc1)N(C)C(=O)N1Cc2c(NC(=O)c3ccccc3)n[nH]c2C1(C)C CHEMBL2064559 Ki 512.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 515.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3[nH]ncc23)n[nH]1 CHEMBL5171469 IC50 515.2 nM
N#Cc1ccc(/C(=C2/C(=O)Nc3ccc(C(=O)N[C@H](CO)c4ccccc4)cc32)c2ncc[nH]2)cc1 CHEMBL4174632 IC50 530.0 nM
CCN(Cc1ccc2[nH]cnc2c1Cl)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 CHEMBL3580976 Ki 547.0 nM
O=C(c1ccccc1Cl)c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 CHEMBL3596899 IC50 550.0 nM
Nc1ccc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cn1 CHEMBL3580964 Ki 563.0 nM
Cc1cc(Nc2nc(C(=O)N(C)C3CCNCC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4073477 Ki 576.0 nM
Cc1nc2ccc(C#C[C@@](C)(O)c3nccs3)cc2n1-c1ncnc(N)n1 CHEMBL3128053 Ki 600.0 nM
CNc1ccc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cn1 CHEMBL3580965 Ki 610.0 nM
CC1(C)c2n[nH]c(Nc3nc(N)nc(Cl)n3)c2CN1C(=O)NC1CC1c1ccccc1 CHEMBL3669585 Ki 610.0 nM
Cc1cc(Nc2nc(NCc3cccc(Cl)c3)nc3[nH]ncc23)n[nH]1 CHEMBL5175294 IC50 610.6 nM
NC1CCN(c2cccc(Nc3cc(C4CC4)[nH]n3)n2)CC1 CHEMBL3580958 Ki 612.0 nM
COCC(C)c1cc(Nc2ccnc(N(C)Cc3ccc4[nH]cnc4c3Cl)n2)n[nH]1 CHEMBL3593825 Ki 617.0 nM
CCN(C[C@H]1CC[C@H](N)CC1)c1nccc(Nc2cc([C@H]3CCN(C)C3=O)[nH]n2)n1 CHEMBL3594178 Ki 621.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C(\c1cccc(F)c1)c1ncc[nH]1 CHEMBL4164394 IC50 621.0 nM
CN(Cc1ccc2[nH]cnc2c1Cl)c1nccc(Nc2cc(C3CCC(=O)C3)[nH]n2)n1 CHEMBL3593824 Ki 629.0 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 630.96 nM
COc1cc(Nc2ncnc(N3CCCc4cc(C)ccc43)n2)cc(OC)c1OC CHEMBL1992125 pKi 630.96 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 630.96 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 630.96 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCCN(C)C)cc2NC3=O)ccc1O CHEMBL1996702 pKi 630.96 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 630.96 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 630.96 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 630.96 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 630.96 nM
CCCNC(=O)c1ccc(Nc2nc(CCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL1984760 pKi 630.96 nM
Clc1ccc2nc(Nc3cnc4[nH]ncc4c3)nc(NCCc3c[nH]c4ccccc34)c2c1 CHEMBL4103825 IC50 633.0 nM
CC(C)(C)[C@@H](CO)NC(=O)c1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL4083545 IC50 634.0 nM
Cc1cc(C)nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)n1 CHEMBL3669600 Ki 640.0 nM
NC1CCN(c2nc(Nc3cn(C4CC4)cn3)c3cc(Cl)ccc3n2)CC1 CHEMBL4102034 Ki 652.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3CC(C)(C)O)n[nH]1 CHEMBL5176789 IC50 654.8 nM
[C-]#[N+]c1ccnc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)c1 CHEMBL3669605 Ki 660.0 nM
Cc1cc(Nc2nc(NCc3ccccc3Cl)nc3[nH]ncc23)n[nH]1 CHEMBL5171233 IC50 668.3 nM
Cc1nc2ccc(C#CC(C)(O)CC3CC3)cc2n1-c1ncnc(N)n1 CHEMBL3128047 Ki 670.0 nM
CNC1CCN(C(=O)c2nc(Nc3cc(C)[nH]n3)c3cc(Cl)ccc3n2)CC1 CHEMBL4097984 Ki 672.0 nM
CC(C)n1nc(-c2cnc(N)c(OC(F)(F)F)c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 CHEMBL3719135 IC50 673.0 nM
Cc1cc(Nc2nc(C(=O)N3CCC(C)(N)CC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4102347 Ki 674.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C/c1cnc(-c2ccccc2)[nH]1 CHEMBL4167423 IC50 689.0 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C(/c1ncc[nH]1)c1ccc(F)cc1F CHEMBL4161228 IC50 706.0 nM
O=C1Nc2cc(F)c(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C/c1ccc[nH]1 CHEMBL4094066 IC50 718.0 nM
CN(C)c1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(N2CCC[C@H]2C(N)=O)n1 CHEMBL3669598 Ki 720.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd apparent 746.0 nM
Cc1cc(Nc2nc(C(=O)N3CCN(C)CC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4066884 Ki 768.0 nM
CNC(=O)[C@@H]1CCCN1c1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(OC)n1 CHEMBL3669594 Ki 770.0 nM
CCn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc21 CHEMBL3609326 IC50 779.0 nM
CC1(C)c2[nH]nc(Nc3cc(C(F)(F)F)ccn3)c2CN1C(=O)NC1C[C@@H]1c1ccccc1 CHEMBL3669601 Ki 780.0 nM
Cc1cc(Nc2nc(C(=O)NC3CNC3)nc3ccc(Cl)cc23)n[nH]1 CHEMBL4087672 Ki 782.0 nM
Brc1ccc2nc(Nc3ccc4[nH]ncc4c3)nc(NCCc3c[nH]c4ccccc34)c2c1 CHEMBL4081560 IC50 788.0 nM
COc1nc(NCCc2c[nH]c3ccccc23)nc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL3799807 IC50 790.0 nM
COc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1980435 pKi 794.33 nM
N#Cc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1977128 pKi 794.33 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(Cl)c1 CHEMBL1983595 pKi 794.33 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 794.33 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 794.33 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 794.33 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 794.33 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 794.33 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 794.33 nM
CCN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL2004637 pKi 794.33 nM
O=C1Nc2ccc(C(=O)N[C@H](CO)c3ccccc3)cc2/C1=C/c1ccco1 CHEMBL4081037 IC50 802.0 nM
CCN1CC[C@H](c2cc(Nc3ccnc(N(C)C[C@H]4CC[C@H](N)CC4)n3)n[nH]2)C1=O CHEMBL3594180 Ki 817.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5ccccc5)c4)c3c2)c1 CHEMBL5394214 IC50 843.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 851.0 nM
CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C CHEMBL1230607 Kd apparent 864.0 nM
CC(C)n1cnc(Nc2nc(N3CCC(N)CC3)nc3ccc(Cl)cc23)c1 CHEMBL4097647 Ki 884.0 nM
Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922094 Kd apparent 904.0 nM
CN(C)c1ccc(CNc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cn1 CHEMBL3580966 Ki 907.0 nM
Fc1ccc2nc(NCCc3c[nH]c4ccccc34)nc(Nc3ccc4[nH]ncc4c3)c2c1 CHEMBL4095923 IC50 920.0 nM
Clc1ccc2nc(Nc3cc(Cl)c4[nH]ncc4c3)nc(NCCc3c[nH]c4ccccc34)c2c1 CHEMBL4087445 IC50 937.0 nM
CN1CC[C@H](c2cc(Nc3ccnc(N(C)Cc4ccc5[nH]cnc5c4Cl)n3)n[nH]2)C1=O CHEMBL3594175 Ki 950.0 nM
CSc1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)cc(C(F)(F)F)n1 CHEMBL3669588 Ki 960.0 nM
c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3[nH]cnc3c2)n1 CHEMBL3580969 Ki 961.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 980.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 1000.0 nM
Cc1ccc(-c2cc3c(NCCN)ccc(C(N)=O)c3[nH]2)cc1 CHEMBL1996048 pKi 1000.0 nM
Cc1cc(Nc2nc(Cl)cc(NCc3ccccc3)n2)n[nH]1 CHEMBL2005449 pKi 1000.0 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 1000.0 nM
CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1995211 pKi 1000.0 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 1000.0 nM
COc1cc(Nc2nccc(Nc3cc(C4CCCCC4)no3)n2)cc(OC)c1OC CHEMBL1984711 pKi 1000.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 1000.0 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL1986666 pKi 1000.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 1000.0 nM
CC1(C)c2n[nH]c(Nc3ncncc3F)c2CN1C(=O)N[C@H]1C[C@@H]1c1ccccc1 CHEMBL3669621 Ki 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM