N#Cc1ccccc1N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)cc(F)c2F)CC1 CHEMBL4169012 IC50 0.02 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(CN3CCSCC3)o2)C1 CHEMBL5401127 IC50 0.02 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C(=O)N4CCN(C(=O)c5ccc(Br)o5)CC4)cc3)nc12 CHEMBL5396891 IC50 0.023 nM
C[C@]1(c2nc3c(C(N)=O)cccc3[nH]2)CCCN1 CHEMBL506871 IC50 0.061 nM
CC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3889630 Ki 0.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccccn2)CC1 CHEMBL4170665 IC50 0.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(CN3CCCCC3)o2)C1 CHEMBL5425729 IC50 0.17 nM
O=C(c1cc(Cc2n[nH]c(=O)c3cccc(O)c23)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL5403789 IC50 0.175 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2nc3ccccc3[nH]2)CC1 CHEMBL4845834 IC50 0.19 nM
Cc1cc(-c2[nH]c(=O)c3cc(F)ccc3c2OCCN)ccc1Cl CHEMBL3933136 IC50 0.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2nccs2)CC1 CHEMBL4159834 IC50 0.2 nM
C[C@]12CCCN1CC1=NNC(=O)c3cc(F)cc4[nH]c2c1c34 CHEMBL4112930 EC50 0.2 nM
O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 CHEMBL63354 IC50 0.2 nM
CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(C(F)(F)F)n21 CHEMBL3907010 IC50 0.2 nM
NC(=O)c1cncc2[nH]c(C3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)nc12 CHEMBL4867855 IC50 0.23 nM
N#Cc1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 CHEMBL5404605 IC50 0.23 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL521686 Kd 0.24 nM
Cc1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 CHEMBL5428376 IC50 0.24 nM
COc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5176874 IC50 0.25 nM
NC(=O)c1ccccc1OCc1cccc(NC(=O)c2ccc(Br)cc2)c1 CHEMBL5416841 IC50 0.25 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccco2)C1 CHEMBL5425393 IC50 0.26 nM
CN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1=O CHEMBL3958202 Ki 0.3 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F CHEMBL2322618 IC50 0.31 nM
CCc1cc2ncc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5095220 IC50 0.31 nM
CCc1cc2ncc(CN3CC4CN(c5ccc(C(=O)NC)nc5)CC4C3)cc2[nH]c1=O CHEMBL5180001 IC50 0.34 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCNCC1 CHEMBL493045 Ki 0.376 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2cnccn2)CC1 CHEMBL2058927 Ki 0.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ncccn2)CC1 CHEMBL2058928 Ki 0.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccc(F)cc2)CC1 CHEMBL4169337 IC50 0.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1 CHEMBL4171279 IC50 0.4 nM
NC(=O)c1ccc(N2CCN(CCCc3cc4c(N)cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL4800042 IC50 0.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nc3ccc(Cl)cc32)C1 CHEMBL4870329 IC50 0.4 nM
CCc1cc2ncc(CN3CCc4cc(/C=C/C(=O)NC)ccc4C3)cc2[nH]c1=O CHEMBL5206717 IC50 0.4 nM
C[C@@H]1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(-c3nccs3)n21 CHEMBL5420649 IC50 0.4 nM
NC1CCN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CC1 CHEMBL5182785 IC50 0.41 nM
CCc1cc2ncc(CN3CCN(c4ccc5cn[nH]c5n4)CC3)cc2[nH]c1=O CHEMBL5176160 IC50 0.41 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2nc(-c3cccc4[nH]ncc34)nc(N3CCOCC3)n2)CC1 CHEMBL4461392 pIC50 0.4365 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccoc2)C1 CHEMBL5395197 IC50 0.44 nM
Cc1ccc2nc3n(c2c1)CCN(C(=O)c1cc(Cc2n[nH]c(=O)c4ccccc24)ccc1F)C3 CHEMBL4870960 IC50 0.47 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nc3ccccc32)C1 CHEMBL4860422 IC50 0.49 nM
Cc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5174780 IC50 0.49 nM
CCc1cc2ncc(CN3CC[C@@H](Nc4ccc(C(=O)NC)nc4)C3)cc2[nH]c1=O CHEMBL5179882 IC50 0.49 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)CN1CCC(c2ccccc2)CC1 CHEMBL595679 IC50 0.5 nM
O=C(N[C@H]1CC(=O)N(c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1=O)OCc1ccccc1 CHEMBL3985672 Ki 0.5 nM
O=C(COc1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3919265 Ki 0.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccccc2)CC1 CHEMBL4161414 IC50 0.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CC2C(=O)N(Cc3ccccc3)C(=O)C2C1 CHEMBL4546114 IC50 0.5 nM
CNCCn1c2c3c4c(cccc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL4776661 EC50 0.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nc3ccc(F)cc32)C1 CHEMBL4867531 IC50 0.51 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC CHEMBL5089136 IC50 0.51 nM
Cn1c(COc2cccc3c(=O)[nH]nc(Cc4ccc(F)c(C(=O)N5CCN(C(=O)C6CC6)CC5)c4)c23)cnc1[N+](=O)[O-] CHEMBL5411944 IC50 0.511 nM
CC1(CCCCCC(=O)NCCOCCOCC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)C(/C=C/C=C/C=C2/N(CCCS(=O)(=O)O)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCS(=O)(=O)[O-])c2ccc(S(=O)(=O)O)cc21 CHEMBL4542543 Ki 0.56 nM
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1 CHEMBL3137320 IC50 0.57 nM
COc1ccccc1NC(=O)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5188771 IC50 0.59 nM
CCc1cc2ncc(CN3CC4(C3)CN(c3ccc(C(=O)NC)nc3)C4)cc2[nH]c1=O CHEMBL5193674 IC50 0.59 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)C2COc3ccccc3O2)CC1 CHEMBL3975785 Ki 0.6 nM
O=C(c1ccc(O)nc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3910874 Ki 0.6 nM
O=C(c1cc[nH]n1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3959275 Ki 0.6 nM
Cc1nc2cc(C(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5CCCC6)ccc4F)CC3)ccc2[nH]1 CHEMBL3940935 Ki 0.6 nM
CCN(CCNC(=O)C1CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3953479 Ki 0.6 nM
O=C(CCCC(=O)Nc1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)Nc1ccccc1 CHEMBL3920948 Ki 0.6 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccc(O)cc2)CC1 CHEMBL4167280 IC50 0.6 nM
N#Cc1ccc(N2CCN(CCCc3cc4c(N)cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL4748390 IC50 0.6 nM
N#Cc1ccc(N2CCN(CCCc3cc4c(N)cccc4c(=O)[nH]3)CC2)cc1 CHEMBL4787850 IC50 0.6 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5c(N)cccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4747106 IC50 0.6 nM
C[C@]12CCCN1CC1=NNC(=O)c3cccc4[nH]c2c1c34 CHEMBL4107982 EC50 0.6 nM
CCN(CC)Cc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 CHEMBL5208255 IC50 0.61 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCC(c2nc3ccccc3[nH]2)CC1 CHEMBL4868967 IC50 0.63 nM
CCc1cc2ncc(CN3CCN(c4ccc(C(=O)NC)c5nccn45)CC3)cc2[nH]c1=O CHEMBL5179448 IC50 0.63 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2nc(-c3cccc4[nH]ccc34)nc(N3CCOCC3)n2)CC1 CHEMBL4437593 pIC50 0.6457 nM
C[C@@H]1CN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CCN1 CHEMBL5203682 IC50 0.66 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2nc(-c3ccc4cn[nH]c4c3)nc(N3CCOCC3)n2)CC1 CHEMBL4549595 pIC50 0.6761 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2nc(-c3ccc4[nH]ccc4c3)nc(N3CCOCC3)n2)CC1 CHEMBL4525998 pIC50 0.6918 nM
N#Cc1cccnc1N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL591515 IC50 0.7 nM
O=C1CCCC(=O)N1c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058682 Ki 0.7 nM
CS(=O)(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL2058922 Ki 0.7 nM
O=C(Nc1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)C1CNC1 CHEMBL3909439 Ki 0.7 nM
COc1ccc(C(=O)CCC(=O)Nc2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)cc1 CHEMBL3940575 Ki 0.7 nM
O=C1C2CC2C(=O)N1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3927171 Ki 0.7 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ncccn2)CC1 CHEMBL1986530 Ki 0.7 nM
CCS(=O)(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3926688 Ki 0.7 nM
COc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4NCCC5)ccc3F)CC2)cc1 CHEMBL3975124 Ki 0.7 nM
O=C1CNC(=O)N1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3960376 Ki 0.7 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)C2CCCC2)CC1 CHEMBL3980638 Ki 0.7 nM
O=C(c1ccc(Cl)nc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3901842 Ki 0.7 nM
O=C(c1ccc2nc[nH]c2c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3934255 Ki 0.7 nM
CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 CHEMBL1173055 IC50 0.7 nM
Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)c(F)c1 CHEMBL4436980 pIC50 0.7244 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5083950 Kd 0.74 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Cl)o2)C1 CHEMBL5408163 IC50 0.74 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4cnco4)cc3)nc12 CHEMBL565882 Ki 0.76 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)cn1 CHEMBL4461382 IC50 0.78 nM
CCc1cc2ncc(CN3CCN(c4ccc5[nH]ncc5n4)CC3)cc2[nH]c1=O CHEMBL5185522 IC50 0.78 nM
O=C1CCCC(=O)N1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3917181 Ki 0.8 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCN(c2ncccn2)CC1 CHEMBL3889976 Ki 0.8 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2cnccn2)CC1 CHEMBL3934902 Ki 0.8 nM
O=C(c1ccco1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3965762 Ki 0.8 nM
O=CN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1N1CCOCC1 CHEMBL3954548 Ki 0.8 nM
CCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3913258 Ki 0.8 nM
O=C(c1cnc2ccccc2c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3896362 Ki 0.8 nM
O=C(NCCN1CCCC1=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3982603 Ki 0.8 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(C2CCCCCC2)CC1 CHEMBL4162463 IC50 0.8 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2cccc(C(F)(F)F)c2)CC1 CHEMBL4175790 IC50 0.8 nM
CNC(=O)c1ccc(N2CCN(CCCc3cc4c(N)cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL4786854 IC50 0.8 nM
CCC(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1CC CHEMBL5084022 IC50 0.83 nM
C[C@@]12CCCN1CC1=NN=C(O)c3cc(F)cc4[nH]c2c1c34 CHEMBL3919533 IC50 0.83 nM
Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)cc1F CHEMBL4571423 pIC50 0.8318 nM
CNCc1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 CHEMBL5419303 IC50 0.86 nM
CC(C)(c1nc2c(C(N)=O)cccc2[nH]1)N1CCCC1 CHEMBL481084 EC50 0.9 nM
O=C1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CCN1 CHEMBL2058916 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)C(F)(F)F)CC1 CHEMBL2058919 Ki 0.9 nM
O=C(c1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL2058920 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2cccnc2)CC1 CHEMBL2058925 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ccccn2)CC1 CHEMBL2058926 Ki 0.9 nM
CN(C)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3892324 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(S(=O)(=O)c2ccccc2)CC1 CHEMBL3950574 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)N2CCCC2)CC1 CHEMBL3974706 Ki 0.9 nM
Cc1cncc(N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4NCCC5)ccc3F)CC2)n1 CHEMBL3936878 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C(=O)N2CCCC2)CC1 CHEMBL3961474 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ncncn2)CC1 CHEMBL3913202 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2cccnc2)CC1 CHEMBL3946265 Ki 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccccc2O)CC1 CHEMBL4175142 IC50 0.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccncc2)CC1 CHEMBL4160023 IC50 0.9 nM
Nc1cc(F)cc2c(=O)[nH]c(CCCN3CCN(c4ccc(F)cc4)CC3)cc12 CHEMBL4781887 IC50 0.9 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)c(F)c1 CHEMBL4753410 IC50 0.9 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncc(F)cc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4789581 IC50 0.9 nM
CCc1cc2ncc(CN3CCN(c4cnc5cn[nH]c5c4)CC3)cc2[nH]c1=O CHEMBL5190645 IC50 0.9 nM
Cc1c(CN2CCN(C(=O)c3cc4cccc(C(N)=O)c4o3)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4865059 IC50 0.91 nM
CCc1cc2ncc(CN3CCC(Nc4ccc(C(=O)NC)nc4)C3)cc2[nH]c1=O CHEMBL5178741 IC50 0.94 nM
CCC(CC)N1CCN(C(=O)c2cc(Cn3c(=O)[n-]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5403305 IC50 0.94 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4cccnc4)cc3)nc12 CHEMBL571285 Ki 0.95 nM
NC1CCN(Cc2cccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)c2)CC1 CHEMBL5197357 IC50 0.96 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(CN3CCC3)o2)C1 CHEMBL5410501 IC50 0.96 nM
CCN(CC)Cc1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 CHEMBL5425070 IC50 0.96 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccno2)C1 CHEMBL5421957 IC50 0.97 nM
O=C(Nc1ccccc1F)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5179949 IC50 0.98 nM
O=S(=O)(NCCCN1CCOCC1)c1ccc2c(c1)Cc1c-2nc(O)c2ccccc12 CHEMBL190434 IC50 1.0 nM
CN1CCC(C)(c2nc3c(C(N)=O)cccc3[nH]2)C1 CHEMBL498007 EC50 1.0 nM
NC(=O)c1cccc2[nH]c(C3CCCN(C4CCCC4)CC3)nc12 CHEMBL460474 EC50 1.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4nnco4)cc3)nc12 CHEMBL569195 Ki 1.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1cccnc1 CHEMBL595018 IC50 1.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)CCn1cnc2ccccc21 CHEMBL596354 IC50 1.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)C1CCNC1 CHEMBL593363 IC50 1.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)C1CNC1 CHEMBL593364 IC50 1.0 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCC(N2CCC2)CC1 CHEMBL589834 IC50 1.0 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCN(c2ncc3ccccc3n2)CC1 CHEMBL603135 IC50 1.0 nM
CC(C)(C)C(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL598543 IC50 1.0 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)cn23)ccc1F)N1CCCNCC1 CHEMBL604291 IC50 1.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc([C@@H]4CCCN4)cc3F)nc12 CHEMBL1090467 Ki 1.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3ccc(C4CCCN4)cc3F)nc12 CHEMBL1088787 EC50 1.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3ccc(C4CCCCN4)cc3)nc12 CHEMBL1088788 EC50 1.0 nM
N#Cc1cccnc1N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4ccccc34)c2)CC1 CHEMBL3740104 IC50 1.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCNCC1 CHEMBL3932477 Ki 1.0 nM
CC1=C(C)C(=O)N(c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1=O CHEMBL3986557 Ki 1.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ccccc2F)CC1 CHEMBL3902883 Ki 1.0 nM
CC(C)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3944818 Ki 1.0 nM
CC(C)(C)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3937699 Ki 1.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)c2cccnc2Cl)CC1 CHEMBL3907393 Ki 1.0 nM
O=C(c1ccc(Cl)nc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3971924 Ki 1.0 nM
O=C(NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)c1ccncc1 CHEMBL3935115 Ki 1.0 nM
CCN(CCNC(=O)c1c(F)cccc1F)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3922304 Ki 1.0 nM
CCN(CCNC(=O)c1cccnc1)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3944750 Ki 1.0 nM
NCCOc1c(-c2ccc(Cl)c(Cl)c2)[nH]c(=O)c2cc(F)ccc12 CHEMBL3901209 IC50 1.0 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4755076 IC50 1.0 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncccc5c(=O)[nH]4)CC3)CC2)nc1 CHEMBL4746309 IC50 1.0 nM
O=c1[nH]nc2c3c(cccc13)N=C(CN1Cc3ccccc3C1)N2 CHEMBL3644587 IC50 1.0 nM
NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 CHEMBL1094636 Kd(app) 1.0 nM
CCc1cc2ncc(CN3CCN(c4ccc(OC(F)F)nc4)CC3)cc2[nH]c1=O CHEMBL5191912 IC50 1.0 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(c2ccccc2)C(=O)C1 CHEMBL5423072 IC50 1.02 nM
Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)cn1 CHEMBL4551779 pIC50 1.072 nM
Nc1cc(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)ccc1F CHEMBL4436366 pIC50 1.096 nM
O=c1[nH]nc2c3c(cccc13)N[C@H](c1ccc(CN3CCC3)cc1)[C@H]2c1ccc(F)cc1 CHEMBL3764920 IC50 1.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCCNCC1 CHEMBL3971025 Ki 1.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ccncc2)CC1 CHEMBL3942547 Ki 1.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ccc(F)cc2F)CC1 CHEMBL3912528 Ki 1.1 nM
CCN(CC)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3926924 Ki 1.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)C2CCCCC2)CC1 CHEMBL3902882 Ki 1.1 nM
CN1CCN(CCNC(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3902104 Ki 1.1 nM
CCS(=O)(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3980444 Ki 1.1 nM
COc1ccc(N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4NCCC5)ccc3F)CC2)cc1 CHEMBL3904253 Ki 1.1 nM
COc1ccc(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4NCCC5)ccc3F)CC2)cc1 CHEMBL3898776 Ki 1.1 nM
O=C(c1cnc(Cl)c(O)c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3928801 Ki 1.1 nM
O=C(c1ccccn1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3954024 Ki 1.1 nM
O=C(c1cscn1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3960942 Ki 1.1 nM
O=C(c1cc[nH]n1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3984269 Ki 1.1 nM
O=C(c1ccc2[nH]cnc2c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3976224 Ki 1.1 nM
O=C(NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)c1ccco1 CHEMBL3983566 Ki 1.1 nM
O=C1CCC(=O)N1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3944277 Ki 1.1 nM
Cn1ncnc1[C@@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@H]1c1ccc(F)cc1 CHEMBL3764816 IC50 1.1 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4776820 IC50 1.1 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)cc1C(F)(F)F CHEMBL4446789 pIC50 1.122 nM
CC(C)(C)OC(=O)NC1CCN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CC1 CHEMBL5193574 IC50 1.17 nM
Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)cc1 CHEMBL4438927 pIC50 1.175 nM
O=C1NCCc2c(-c3ccc(CN4CCN(c5ncccn5)CC4)cc3)[nH]c3cc(F)cc1c23 CHEMBL5170407 IC50 1.19 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C(F)(F)F)cc3)nc12 CHEMBL334734 Ki 1.2 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4cnc[nH]4)cc3)nc12 CHEMBL576319 Ki 1.2 nM
CN(C)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL2058921 Ki 1.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ccccc2)CC1 CHEMBL2058923 Ki 1.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ccncc2)CC1 CHEMBL2058924 Ki 1.2 nM
O=C1CCCN1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL2058929 Ki 1.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)C2CCCO2)CC1 CHEMBL3927345 Ki 1.2 nM
CC(C)n1nnc2cc(C(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5NCCC6)ccc4F)CC3)ccc21 CHEMBL3982698 Ki 1.2 nM
Cc1nc2cc(C(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5NCCC6)ccc4F)CC3)ccc2[nH]1 CHEMBL3956370 Ki 1.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ncncn2)CC1 CHEMBL3977588 Ki 1.2 nM
O=C1CCC(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4CCCC5)ccc3F)CC2)N1 CHEMBL3891936 Ki 1.2 nM
O=C(c1cccnc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3931503 Ki 1.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2cncnc2)CC1 CHEMBL3978757 Ki 1.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(CN3CCCC3)o2)C1 CHEMBL5432616 IC50 1.26 nM
NC(=O)c1ccccc1OCc1cccc(NC(=O)c2ccc(Cl)cc2)c1 CHEMBL5427365 IC50 1.28 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(CN3CCOCC3)o2)C1 CHEMBL5429957 IC50 1.28 nM
CC(C)(C)[Si](C)(C)OCCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL4569417 IC50 1.29 nM
CNC(C)(C)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL481081 EC50 1.3 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)[C@@]4(C)CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL597927 IC50 1.3 nM
O=C(CCC(=O)c1ccccc1)Nc1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058688 Ki 1.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL2058917 Ki 1.3 nM
CC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL2058918 Ki 1.3 nM
CC(=O)CCCC(=O)Nc1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3937647 Ki 1.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCC(O)CC1 CHEMBL3971091 Ki 1.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(S(=O)(=O)c2ccccc2)CC1 CHEMBL3957957 Ki 1.3 nM
CCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3904765 Ki 1.3 nM
CC(C)(C)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3903698 Ki 1.3 nM
O=C(c1ccc(Cl)cn1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3951776 Ki 1.3 nM
O=C(c1cncnc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3958439 Ki 1.3 nM
O=C(c1cnc(O)c(Cl)c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3955635 Ki 1.3 nM
O=C(c1ccccn1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3949787 Ki 1.3 nM
O=C(c1ccc2ccccc2n1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3908116 Ki 1.3 nM
N#Cc1cccnc1N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)cc(F)c2F)CC1 CHEMBL4174093 IC50 1.3 nM
O=C1NN=C2CN(C(=O)C3CC3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL3983859 EC50 1.3 nM
CC(C)N1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3931972 EC50 1.3 nM
CCc1cc2ncc(CN3CCN(c4ccc5cc[nH]c5n4)CC3)cc2[nH]c1=O CHEMBL5205419 IC50 1.3 nM
CC(=O)N1CCN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CC1 CHEMBL5183006 IC50 1.31 nM
CN(C)Cc1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 CHEMBL5435418 IC50 1.35 nM
Cc1nnc2n1N=C(c1ccccc1OCCNCCCNCCOc1ccccc1C1=Nn3c(C)nnc3SC1)CS2 CHEMBL5275672 IC50 1.37 nM
CNCc1ccc(-n2cc3cc(F)cc(C(N)=O)c3n2)cc1 CHEMBL610171 IC50 1.4 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCN(c2ncnc3ccccc23)CC1 CHEMBL596713 IC50 1.4 nM
NC(=O)c1cccc2cn(-c3ccc4c(c3)CCNC4)nc12 CHEMBL1098296 IC50 1.4 nM
O=C1NCCc2c(-c3ccc(CN4CCCC4)cc3)[nH]c3cccc1c23 CHEMBL1173054 Ki 1.4 nM
O=C1CCC(=O)N1c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058681 Ki 1.4 nM
O=C(CCCC(=O)Nc1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)Nc1ccccc1 CHEMBL2058687 Ki 1.4 nM
CC(C)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3982693 Ki 1.4 nM
O=C(c1ccncc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3899153 Ki 1.4 nM
O=C(c1cnccn1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3946931 Ki 1.4 nM
O=C(c1cscn1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3918245 Ki 1.4 nM
O=C(c1ccncc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3967707 Ki 1.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C(=O)[C@@H]2CSCN2)CC1 CHEMBL3969605 Ki 1.4 nM
O=C(NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)c1ccc2cn[nH]c2c1 CHEMBL3954947 Ki 1.4 nM
O=C(NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)c1cn[nH]c1 CHEMBL3921828 Ki 1.4 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(CCC2CC2)C1 CHEMBL4067999 IC50 1.4 nM
CCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)cc(F)c2F)CC1 CHEMBL4161687 IC50 1.4 nM
CCN1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3908123 EC50 1.4 nM
CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 CHEMBL2105733 Ki 1.4 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(C2CCCC2)C(=O)C1 CHEMBL5439635 IC50 1.4 nM
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cccc(c23)N[C@@H]1c1ccc(F)cc1 CHEMBL3763446 IC50 1.46 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2nc(C(F)(F)F)nc2C1 CHEMBL3930624 IC50 1.46 nM
NCCOCCOCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL4564916 Ki 1.48 nM
CN1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3953380 Ki 1.5 nM
O=C(c1ccc2ccccc2n1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3972905 Ki 1.5 nM
O=C(c1cccnc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3970344 Ki 1.5 nM
O=C(c1cnccn1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3930573 Ki 1.5 nM
CCOC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3893791 Ki 1.5 nM
CC1(C)SCN[C@@H]1C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3964387 Ki 1.5 nM
O=C(c1ccc(O)nc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3972935 Ki 1.5 nM
O=C(NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)c1ccccn1 CHEMBL3926216 Ki 1.5 nM
O=C(NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)c1cccnc1 CHEMBL3962600 Ki 1.5 nM
O=C(NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)c1cscn1 CHEMBL3898349 Ki 1.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C(=O)c2cccnc2Cl)CC1 CHEMBL3970477 Ki 1.5 nM
Cc1c(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4858564 IC50 1.5 nM
O=C(Nc1ccc(F)cc1)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5189723 IC50 1.54 nM
O=C1NCCc2c(-c3ccc(CN4CCN(CCO)CC4)cc3)[nH]c3cc(F)cc1c23 CHEMBL5174694 IC50 1.54 nM
NC(=O)c1cccc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL133241 Ki 1.6 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4n[nH]c(=O)o4)cc3)nc12 CHEMBL576910 Ki 1.6 nM
O=C(c1cc(Cc2c[nH]c(=O)c3c(Cl)c(Cl)cn23)ccc1F)N1CCCNCC1 CHEMBL599793 IC50 1.6 nM
Cc1cc2c(=O)[nH]cc(Cc3ccc(F)c(C(=O)N4CCCNCC4)c3)n2c1 CHEMBL610164 IC50 1.6 nM
NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL2058912 Ki 1.6 nM
Cn1ccnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1 CHEMBL3764202 IC50 1.6 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL3897941 Ki 1.6 nM
Cc1cncc(N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4CCCC5)ccc3F)CC2)n1 CHEMBL3933583 Ki 1.6 nM
O=C(c1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3943609 Ki 1.6 nM
O=C(c1ccc2cc[nH]c2c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3903770 Ki 1.6 nM
CC1(C)SCNC1C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3934769 Ki 1.6 nM
Cc1ccccc1NC(=O)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5172909 IC50 1.62 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4cscn4)cc3)nc12 CHEMBL574147 Ki 1.7 nM
COc1ccc(C(=O)C2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4NCCC5)ccc3F)CC2)cc1 CHEMBL3947204 Ki 1.7 nM
CC(C)n1c(C(F)(F)F)nc2cc(C(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5NCCC6)ccc4F)CC3)ccc21 CHEMBL3984109 Ki 1.7 nM
O=C(c1ccco1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3902005 Ki 1.7 nM
O=C(c1cncnc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3912900 Ki 1.7 nM
COC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL4098253 IC50 1.7 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc2c1OCC2)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4442022 IC50 1.7 nM
CC1(C)CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3911687 EC50 1.7 nM
CCOc1ncc(C(N)=O)c2nc(C3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)[nH]c12 CHEMBL4857326 IC50 1.7 nM
CN(C)C(C)(C)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL481082 EC50 1.8 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C(C)(C)N(C)C)CC3)c2)n[nH]c(=O)c1C CHEMBL605575 IC50 1.8 nM
C=CCC1(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c(C)c4C)ccc3F)CC2)CCCN1 CHEMBL590632 IC50 1.8 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCN(c2cc3ccccc3cn2)CC1 CHEMBL590805 IC50 1.8 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cccn23)ccc1F)N1CCCNCC1 CHEMBL597339 IC50 1.8 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCNCC1 CHEMBL2058911 Ki 1.8 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL2323218 IC50 1.8 nM
CCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3927211 Ki 1.8 nM
O=C(c1ccccc1)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3950202 Ki 1.8 nM
O=C(OCc1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3924863 Ki 1.8 nM
CC1(C(=O)N2CCCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4CCCC5)ccc3F)CC2)CC1 CHEMBL3967308 Ki 1.8 nM
Cn1cnc(C(=O)N2CCCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4CCCC5)ccc3F)CC2)c1 CHEMBL3937652 Ki 1.8 nM
O=C(NC1CCN(C(=O)c2ccc3[nH]cnc3c2)CC1)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3912710 Ki 1.8 nM
CC(C)n1nnc2cc(C(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5CCCC6)ccc4F)CC3)ccc21 CHEMBL3898412 Ki 1.8 nM
CCN(CCNC(=O)c1ccccc1)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3913570 Ki 1.8 nM
Nc1ccc(F)cc1NC(=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL4642383 IC50 1.81 nM
Cn1nccc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccc(F)cc1 CHEMBL3764188 IC50 1.84 nM
Cn1ccnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccc(F)cc1 CHEMBL3764085 IC50 1.87 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4ccccn4)cc3)nc12 CHEMBL576423 Ki 1.9 nM
NC(=O)c1cccc2cn(-c3ccc(CN4CCCCC4)cc3)nc12 CHEMBL1097627 IC50 1.9 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL2323222 IC50 1.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C(=O)N2CCCCC2)CC1 CHEMBL3906957 Ki 1.9 nM
O=C(c1ccco1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3935119 Ki 1.9 nM
O=C(COc1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3891180 Ki 1.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCCN(C(=O)C2CC2)CC1 CHEMBL3943016 Ki 1.9 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3906980 Ki 1.9 nM
O=C(c1ccc2nc[nH]c2c1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3957687 Ki 1.9 nM
COc1ccc(C(=O)CCC(=O)Nc2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)cc1 CHEMBL3916058 Ki 1.9 nM
CCCCN1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3905389 EC50 1.9 nM
Cc1c(CN2CCN(C(=O)c3cc4cccc(C(N)=O)c4o3)CC2)sc2c(N3CCOCC3)nc(-c3ccc(N)nc3)nc12 CHEMBL4859306 IC50 1.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2C2CCOC2)C1 CHEMBL5397203 IC50 1.91 nM
CC(C)(C)OC(=O)NCCOCCOCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL4444472 Ki 1.92 nM
Nc1ccccc1NC(=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL4639985 IC50 1.94 nM
Cc1ccc(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccc(CN(C)C)cc2)cc1 CHEMBL3763531 IC50 1.95 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5s4)CC3)oc12 CHEMBL4871210 IC50 1.98 nM
COc1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1O CHEMBL338923 Ki 2.0 nM
CC(C)N1CCC(C)(c2nc3c(C(N)=O)cccc3[nH]2)C1 CHEMBL495969 EC50 2.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCCCN1 CHEMBL521712 EC50 2.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCN(CCc2ccccc2)C1 CHEMBL496976 EC50 2.0 nM
C[C@]1(c2nc3c(C(N)=O)cc(F)cc3[nH]2)CCCN1 CHEMBL495743 EC50 2.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCCN(C2CCCC2)CC1 CHEMBL498015 EC50 2.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1)N1CCN(c2ncccn2)CC1 CHEMBL521809 IC50 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2ccccn2)CC1 CHEMBL523058 IC50 2.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1)N1CCNCC1 CHEMBL201616 IC50 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CCOC2)CC1 CHEMBL524165 IC50 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CCCC2)CC1 CHEMBL524190 IC50 2.0 nM
NC(=O)c1cccc2[nH]c(C3CCN(C4CCCC4)C3)nc12 CHEMBL453059 EC50 2.0 nM
CC(C)(NCC1CC1)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL517843 EC50 2.0 nM
CC(C)NC(C)(C)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL479779 EC50 2.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4ccccc4)cc3)nc12 CHEMBL578185 Ki 2.0 nM
CNCc1ccc(-n2cc3cc(F)cc(C(N)=O)c3n2)cc1F CHEMBL609020 IC50 2.0 nM
CNC(C)(C)C(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL590791 IC50 2.0 nM
CN(C)C(=O)C(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL603873 IC50 2.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCNCC4)cc3)nc12 CHEMBL1090136 Ki 2.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3ccc(C4CCCN4)cc3)nc12 CHEMBL1092225 Ki 2.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3ccc(C4CCCCN4)cc3F)nc12 CHEMBL1089132 Ki 2.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4ccncc4)cc3)nc12 CHEMBL577549 Ki 2.0 nM
CN1CCCCC1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1090482 EC50 2.0 nM
O=C(CCC(=O)N1CCC[C@H]1C(=O)O)c1ccc2[nH]c3c4c(c5c(c3c2c1)C(=O)NC5=O)CCC4 CHEMBL1935274 IC50 2.0 nM
NCC(=O)Nc1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3918368 Ki 2.0 nM
CC(=O)Nc1cccc(-c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)c1 CHEMBL3920506 Ki 2.0 nM
O=C1C2CCCCC2C(=O)N1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3985126 Ki 2.0 nM
CC1CCC(=O)N1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3980127 Ki 2.0 nM
O=C1CCCCCN1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3972076 Ki 2.0 nM
O=C1CCCCN1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3968312 Ki 2.0 nM
O=C1CCC(=O)N1c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1 CHEMBL3899235 Ki 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)N2CCOCC2)CC1 CHEMBL3910994 Ki 2.0 nM
O=C(CCOc1ccccc1)Nc1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3904375 Ki 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ccccn2)CC1 CHEMBL2058930 Ki 2.0 nM
CCN(CC)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3948164 Ki 2.0 nM
CC(C)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3983709 Ki 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C(=O)N2CCOCC2)CC1 CHEMBL3927874 Ki 2.0 nM
NC(=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3977581 Ki 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ccc(F)cc2)CC1 CHEMBL3917960 Ki 2.0 nM
CN(C)C(=O)CN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3983267 Ki 2.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C2CCCC2)CC1 CHEMBL3930456 Ki 2.0 nM
O=C(c1cnccn1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3973041 Ki 2.0 nM
CCN1CCCC2CN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC21 CHEMBL4579526 IC50 2.0 nM
CCc1cc2cnc(CN3CCN(c4ccc(C(=O)NC)nc4F)CC3)cc2[nH]c1=O CHEMBL4861603 IC50 2.0 nM
CCc1cc2cnc(CN3CCN(c4ccc(C(N)=O)nc4)CC3)cc2[nH]c1=O CHEMBL4867071 IC50 2.0 nM
CNC(=O)c1ccc(N2CCN(Cc3cc4[nH]c(=O)c(CCF)cc4cn3)CC2)cn1 CHEMBL4851402 IC50 2.0 nM
N#Cc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)C3CCCNC43)CC2)nc1 CHEMBL5206816 IC50 2.0 nM
CCc1cc2ncc(CN3CCN(c4ccc5oc(=O)[nH]c5c4)CC3)cc2[nH]c1=O CHEMBL5196723 IC50 2.0 nM
CN1CCN(Cc2ccc(C3Nc4cccc5c(=O)[nH]nc(c45)C3c3ccccc3)cc2)CC1 CHEMBL3764829 IC50 2.02 nM
O=c1[nH]nc2c3c(cccc13)NC(c1ccc(CN3CCCC3)cc1)C2c1ccc(F)cc1 CHEMBL3765318 IC50 2.02 nM
Cn1ccnc1C1c2n[nH]c(=O)c3cccc(c23)NC1c1ccc(F)cc1 CHEMBL3765434 IC50 2.08 nM
CC(=O)Nc1ccc(C2Nc3cc(F)cc4c(=O)[nH]nc(c34)C2c2ncnn2C)cc1 CHEMBL3764951 IC50 2.08 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CCC1CC1 CHEMBL5437813 IC50 2.08 nM
CC(C)C(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL592543 IC50 2.1 nM
NC(=O)c1cccc2cn(-c3ccc(CNCCF)cc3)nc12 CHEMBL1096883 IC50 2.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2ccccc2Cl)CC1 CHEMBL3896377 Ki 2.1 nM
O=C(c1ccc(F)cc1)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3958755 Ki 2.1 nM
O=C(c1cc[nH]n1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3965685 Ki 2.1 nM
CCCCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)cc(F)c2F)CC1 CHEMBL4172321 IC50 2.1 nM
Cn1ccnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccccc1 CHEMBL3763188 IC50 2.14 nM
Cn1ncnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccc(F)cc1 CHEMBL3765528 IC50 2.14 nM
Cc1nc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cs1 CHEMBL5427132 IC50 2.14 nM
C=C1C(=O)OC2C[C@@]3(C)CCC=C(COC(=O)CCN(C)C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)C3=CC12 CHEMBL5176961 IC50 2.18 nM
Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2 CHEMBL1086580 IC50 2.194 nM
Cc1nn(C)c2[nH]c(=O)c3c(c12)CCCC3 CHEMBL455590 IC50 2.2 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4ncc[nH]4)cc3)nc12 CHEMBL565881 Ki 2.2 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4csc(N)n4)cc3)nc12 CHEMBL571928 Ki 2.2 nM
NC(=O)c1cccc2cn(-c3ccc4c(c3)CNCC4)nc12 CHEMBL1095606 IC50 2.2 nM
COc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4CCCC5)ccc3F)CC2)cc1 CHEMBL3911539 Ki 2.2 nM
O=C(c1cncnc1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3986414 Ki 2.2 nM
CN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1=O CHEMBL3911036 Ki 2.2 nM
Cn1ccnc1[C@H]1c2n[nH]c(=O)c3cccc(c23)N[C@@H]1c1ccc(F)cc1 CHEMBL3763822 IC50 2.25 nM
Cn1ncnc1C1c2n[nH]c(=O)c3cccc(c23)NC1c1ccc(F)cc1 CHEMBL3765056 IC50 2.29 nM
CNC1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL603407 IC50 2.3 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCNCC1 CHEMBL590880 IC50 2.3 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL3739650 IC50 2.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2cccc(F)c2)CC1 CHEMBL3949287 Ki 2.3 nM
N[C@H]1CC(=O)N(c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1=O CHEMBL3896875 Ki 2.3 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3965502 Ki 2.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCCN(C(=O)[C@@H]2CSCN2)CC1 CHEMBL3925437 Ki 2.3 nM
O=C(c1cscn1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3894247 Ki 2.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(C(=O)N2CCOCC2)CC1 CHEMBL4167044 IC50 2.3 nM
CC1(C)CC2=NNC(=O)c3cccc4c3c2c(n4CC2CO2)C1 CHEMBL3940569 EC50 2.3 nM
O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1)NCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O CHEMBL4783227 IC50 2.3 nM
CC1=C(NN)SC(NNS(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)N1C(=O)c1ccccc1 CHEMBL5411446 IC50 2.31 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(C3CCOCC3)o2)C1 CHEMBL5412306 IC50 2.33 nM
Cn1ccnc1C1c2n[nH]c(=O)c3cccc(c23)NC1c1ccccc1 CHEMBL3765291 IC50 2.35 nM
CN(C)Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccccc2)cc1 CHEMBL3764052 IC50 2.36 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CCCCC1 CHEMBL5421335 IC50 2.38 nM
CN(C)CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5393999 IC50 2.39 nM
Cc1nc(-c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)co1 CHEMBL583933 Ki 2.4 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(NCC5CC5)CCCC4)CC3)c2)n[nH]c(=O)c1C CHEMBL597314 IC50 2.4 nM
CN(C)S(=O)(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL597116 IC50 2.4 nM
O=C(c1ccccn1)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL598751 IC50 2.4 nM
NC(=O)c1cccc2cn(-c3ccc([C@H]4CCCNC4)cc3)nc12 CHEMBL1097260 IC50 2.4 nM
Cn1ncnc1C1c2n[nH]c(=O)c3cccc(c23)NC1c1ccccc1 CHEMBL3765125 IC50 2.4 nM
COc1ccc(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4CCCC5)ccc3F)CC2)cc1 CHEMBL3917596 Ki 2.4 nM
O=C(c1ccncc1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3908724 Ki 2.4 nM
O=C(c1cnc2ccccc2c1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3949072 Ki 2.4 nM
CC(C)n1nnc2cc(C(=O)N3CCCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5NCCC6)ccc4F)CC3)ccc21 CHEMBL3943733 Ki 2.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(C(=O)C2CCCO2)CC1 CHEMBL4174278 IC50 2.4 nM
CN(C)CCn1c2c3c4c(cc(F)cc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL3929889 EC50 2.4 nM
CC(C)C1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3925115 EC50 2.4 nM
COc1ncc(C(N)=O)c2nc(C3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)[nH]c12 CHEMBL4855366 IC50 2.4 nM
CCCCNCc1ccc(-c2[nH]c3cc(F)cc4c3c2C(=O)NNC4=O)cc1 CHEMBL3617774 IC50 2.416 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CCCC1 CHEMBL5397373 IC50 2.46 nM
CN(C)Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(F)cc2)cc1 CHEMBL3764422 IC50 2.48 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)[C@]4(Cc5ccc(F)cc5)CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL590548 IC50 2.5 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCC2(CCCN2)CC1 CHEMBL606029 IC50 2.5 nM
CN(C)CC(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL597117 IC50 2.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C2CCCC2)CC1 CHEMBL2058915 Ki 2.5 nM
O=C(CN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1)N1CCCC1 CHEMBL3919621 Ki 2.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(C(=O)C2CCCCC2)CC1 CHEMBL3912155 Ki 2.5 nM
O=C(OCc1ccccc1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3935333 Ki 2.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2cncnc2)CC1 CHEMBL3965443 Ki 2.5 nM
N#Cc1ccc(N2CCN([C@@H]3C=C(c4cc5c(N)cccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4741921 IC50 2.5 nM
Cc1cc2ncc([C@@H](C)N3CCN(c4ccc(C#N)cn4)CC3)cc2[nH]c1=O CHEMBL5404845 pIC50 2.512 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1Cc1ccccc1 CHEMBL5418896 IC50 2.54 nM
Nc1ncc(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL4438741 pIC50 2.57 nM
Nc1cc(F)ccc1NC(=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL4637848 IC50 2.58 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCC4(CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL598145 IC50 2.6 nM
CN(C)C1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL590327 IC50 2.6 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCCNCC1 CHEMBL596933 IC50 2.6 nM
Cn1ncnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccccc1 CHEMBL3763497 IC50 2.6 nM
CC(C)(N)C(=O)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3970252 IC50 2.6 nM
O=C(c1cccnc1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3897575 Ki 2.6 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCN(C(=O)c2cn[nH]c2)CC1 CHEMBL3914521 Ki 2.6 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(C2CCCC2)CC1 CHEMBL4165908 IC50 2.6 nM
CCc1cc2ncc(CN3CCN(c4ccc5nc(C(F)(F)F)[nH]c5n4)CC3)cc2[nH]c1=O CHEMBL5185548 IC50 2.6 nM
CCc1cc2ncc(CN3CC(Nc4ccc(C(=O)NC)nc4)C3)cc2[nH]c1=O CHEMBL5173989 IC50 2.6 nM
CN(C)Cc1cccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccccc2)c1 CHEMBL3764190 IC50 2.63 nM
CN(C)Cc1ccc(C2Nc3cc(F)cc4c(=O)[nH]nc(c34)C2c2ccc(F)cc2)cc1 CHEMBL3765611 IC50 2.63 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCCNC(=O)CCCCCCCCCCC(=O)N4CCN(C(=O)c5cc(Cc6n[nH]c(=O)c7ccccc67)ccc5F)CC4)c3C2=O)C1=O CHEMBL4795449 IC50 2.64 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccc(O)cc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL5403607 IC50 2.66 nM
CNC1(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c(C)c4C)ccc3F)CC2)CCCC1 CHEMBL597313 IC50 2.7 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(N5CCCC5)CCCC4)CC3)c2)n[nH]c(=O)c1C CHEMBL596702 IC50 2.7 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)[C@H]4CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL605760 IC50 2.7 nM
NC(=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3914571 Ki 2.7 nM
Cc1nc2cc(C(=O)N3CCCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5NCCC6)ccc4F)CC3)ccc2[nH]1 CHEMBL3973251 Ki 2.7 nM
CCN(CCNC(=O)N1CCCC1)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3983389 Ki 2.7 nM
CC1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3910080 EC50 2.7 nM
CCCCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5437947 IC50 2.71 nM
CCCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5394020 IC50 2.72 nM
O=C(COc1ccc2c(c1)CCCN2C(=O)CCl)NCCCCCCCCCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL5182405 IC50 2.74 nM
Cn1cnnc1C1c2n[nH]c(=O)c3cccc(c23)NC1c1ccccc1 CHEMBL3764995 IC50 2.76 nM
NC(=O)c1cc(F)cc2[nH]c(C(=O)N3CCC(N)CC3)nc12 CHEMBL4080699 IC50 2.76 nM
CC1C(=O)NN=C(Cc2ccc(F)c(C(=O)C3CC(=O)N(C4CCC4)C(C)C3)c2)C1C CHEMBL5174011 IC50 2.77 nM
CC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1C CHEMBL5073404 IC50 2.79 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(C)CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL605552 IC50 2.8 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(C)CCCO4)CC3)c2)n[nH]c(=O)c1C CHEMBL598138 IC50 2.8 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCN(c2ccccn2)CC1 CHEMBL604040 IC50 2.8 nM
COc1ccccc1N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3979927 Ki 2.8 nM
O=C(c1ccccn1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3972264 Ki 2.8 nM
CC(C)(C)OC(=O)NC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3900920 Ki 2.8 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(C2CCCCC2)C(=O)C1 CHEMBL5416806 IC50 2.85 nM
Cn1nccc1C1Nc2cc(F)cc3c(=O)[nH]nc(c23)C1c1ncnn1C CHEMBL3763705 IC50 2.88 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4cn5ccccc5n4)cc3)nc12 CHEMBL578397 Ki 2.9 nM
CC1(C)CC2=NNC(=O)c3cccc4c3c2c(n4CCN2CCCCC2)C1 CHEMBL3984980 IC50 2.9 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ncccn2)CC1 CHEMBL4177196 IC50 2.9 nM
CC(C)(N)C(=O)N1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3905040 EC50 2.9 nM
CC1(C)CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3972156 EC50 2.9 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(=O)C(F)(F)F CHEMBL5079913 IC50 2.92 nM
O=C1CCC(N2C(=O)c3cccc(NC(=O)CNCCCCCCCCCCC(=O)N4CCN(C(=O)c5cc(Cc6n[nH]c(=O)c7ccccc67)ccc5F)CC4)c3C2=O)C(=O)N1 CHEMBL5186485 IC50 2.95 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5o4)CC3)oc12 CHEMBL4868231 IC50 2.97 nM
C[C@H]1CCC[C@]2(C)CC3OC(=O)C(CNCCCCCCCC(=O)N4CCN(C(=O)c5cc(Cc6n[nH]c(=O)c7ccccc67)ccc5F)CC4)C3C=C12 CHEMBL5179564 IC50 2.991 nM
NC(=O)c1cccc2[nH]c(-c3ccc(Cl)cc3)nc12 CHEMBL131891 Ki 3.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCCNCC1 CHEMBL521714 Ki 3.0 nM
C[C@@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCCN1 CHEMBL497608 EC50 3.0 nM
CN1CCCC1(C)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL497609 EC50 3.0 nM
CC(C)N1CC(C)(c2nc3c(C(N)=O)cccc3[nH]2)C1 CHEMBL506516 EC50 3.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCCN1 CHEMBL521880 EC50 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2ncccn2)CC1 CHEMBL523686 IC50 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CCCO2)CC1 CHEMBL492671 IC50 3.0 nM
CCCN1CCC(c2nc3c(C(N)=O)cccc3[nH]2)C1 CHEMBL500298 EC50 3.0 nM
N#Cc1ccc(N2CCC(c3nc4c(C(N)=O)cccc4[nH]3)CC2)cc1 CHEMBL459853 Ki 3.0 nM
CCCN1CCC(c2nc3cccc(C(N)=O)c3[nH]2)CC1 CHEMBL452800 EC50 3.0 nM
CCCNC(C)(C)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL479778 EC50 3.0 nM
N#Cc1ccc(C2=CCN(CCCc3nc4c(Cl)cccc4c(=O)[nH]3)CC2)cc1 CHEMBL481511 IC50 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCN4)cc3)nc12 CHEMBL1093844 Ki 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCNC4)cc3)nc12 CHEMBL1093845 Ki 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCNC4)cc3)nc12 CHEMBL1092691 Ki 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCN4)cc3F)nc12 CHEMBL1093309 Ki 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc([C@H]4CCCCN4)cc3F)nc12 CHEMBL1089124 EC50 3.0 nM
O=C(O)CCC(=O)c1ccc2[nH]c3c4c(c5c(c3c2c1)C(=O)NC5=O)CCC4 CHEMBL1935262 IC50 3.0 nM
O=C1CCN1c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058680 Ki 3.0 nM
CC1Oc2ccc(CN3CC=C(c4ccc(Cl)cc4)CC3)cc2NC1=O CHEMBL2408002 Kd 3.0 nM
O=C(COc1ccc(I)cc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL3735519 IC50 3.0 nM
O=C(O)CCC(=O)Nc1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3925288 Ki 3.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCN(C(=O)c2ccno2)CC1 CHEMBL3922478 Ki 3.0 nM
O=C(CCCC(=O)Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)Nc1ccccc1 CHEMBL3910314 Ki 3.0 nM
O=c1[nH]nc(Cc2ccc(F)c(N3CCCS3(=O)=O)c2)c2c1CCCC2 CHEMBL3908235 Ki 3.0 nM
CC(=O)N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)CC1 CHEMBL3959527 Ki 3.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCN(c2ccccc2)CC1 CHEMBL3939380 Ki 3.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCN(c2ccccn2)CC1 CHEMBL3911333 Ki 3.0 nM
NC(=O)C1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1 CHEMBL3943233 Ki 3.0 nM
CN1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3972582 Ki 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ccccc2)CC1 CHEMBL3907837 Ki 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2cccc(F)c2)CC1 CHEMBL3955721 Ki 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(CCOc2ccccc2)CC1 CHEMBL3951203 Ki 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCC(O)CC1 CHEMBL3917313 Ki 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(CCOc2ccccc2)CC1 CHEMBL3935873 Ki 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(c2cccc(C(F)(F)F)c2)CC1 CHEMBL3966619 Ki 3.0 nM
O=C(c1cccc(Cl)c1)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3984680 Ki 3.0 nM
COc1ccc(N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4CCCC5)ccc3F)CC2)cc1 CHEMBL3978197 Ki 3.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)[C@@H]2CSCN2)CC1 CHEMBL3936400 Ki 3.0 nM
CN1CCN(C2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5c4NCCC5)ccc3F)CC2)CC1 CHEMBL3950585 Ki 3.0 nM
CCN(CCNC(=O)OC(C)(C)C)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3900192 Ki 3.0 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCN(C(=O)c2ccccn2)CC1 CHEMBL3901005 Ki 3.0 nM
CCc1cc2cnc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL4874589 IC50 3.0 nM
CCc1cc2cnc(CN3CCN(c4ccc(C(=O)NC)nc4Cl)CC3)cc2[nH]c1=O CHEMBL4857071 IC50 3.0 nM
CNC(=O)c1ccc(N2CCN(Cc3cc4[nH]c(=O)c(CC(F)F)cc4cn3)CC2)c(F)n1 CHEMBL4859590 IC50 3.0 nM
CCc1nc2c(F)cc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5398113 IC50 3.0 nM
O=C(NC1CC1)c1ccc(N2CCN(Cc3ccc4cc(C(F)F)c(=O)[nH]c4c3F)CC2)c(F)n1 CHEMBL5395193 IC50 3.0 nM
N#Cc1ccc(C2CCN(CCCc3nc4c(Cl)cccc4c(=O)[nH]3)CC2)cc1 CHEMBL5398361 IC50 3.0 nM
C[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5083291 IC50 3.02 nM
CCC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5404171 IC50 3.02 nM
CC(C)CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5406001 IC50 3.03 nM
Cc1cc(C)n(S(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)n1 CHEMBL5441085 IC50 3.05 nM
O=c1[nH]nc2c3c(cccc13)NC(c1ccc(CN3CCC3)cc1)C2c1ccc(F)cc1 CHEMBL3763674 IC50 3.09 nM
CC(C)(c1nc2c(C(N)=O)cccc2[nH]1)N1CCCCC1 CHEMBL479937 EC50 3.1 nM
CCNC1(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c(C)c4C)ccc3F)CC2)CCCC1 CHEMBL603235 IC50 3.1 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)[C@@H]4CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL599167 IC50 3.1 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)[C@@]4(C)CCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL591589 IC50 3.1 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCN(c2ncccn2)CC1 CHEMBL589257 IC50 3.1 nM
O=C(c1ncc[nH]1)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL603457 IC50 3.1 nM
NC(=O)c1cccc2cn(-c3ccc(C4CCCN4)cc3)nc12 CHEMBL1098297 IC50 3.1 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(CCC(F)(F)F)C1 CHEMBL4083291 IC50 3.1 nM
O=C1NN=C2CCCCc3[nH]c4cccc1c4c32 CHEMBL3969742 EC50 3.1 nM
CCc1nc2c(F)cc(CN3CCN(c4ccc(C#N)cn4)CC3)cc2[nH]c1=O CHEMBL5395156 pIC50 3.162 nM
O=c1[nH]c2cc(CN3CCN(c4ccc(F)cn4)CC3)cnc2cc1C1CC1 CHEMBL5406766 pIC50 3.162 nM
[2H]C([2H])(c1cnc2cc(C)c(=O)[nH]c2c1)N1CCN(c2ccc(C#N)cn2)CC1 CHEMBL5428908 pIC50 3.162 nM
CNCc1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL83916 Ki 3.2 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(NCC5CC5)CCC4)CC3)c2)n[nH]c(=O)c1C CHEMBL598957 IC50 3.2 nM
CCC(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL605284 IC50 3.2 nM
NC(=O)c1cccc2cn(-c3ccc(C4CCCNC4)cc3)nc12 CHEMBL1098298 IC50 3.2 nM
CNCc1ccc(-c2cc3cc(F)cc(C(N)=O)c3o2)cc1 CHEMBL4584534 IC50 3.2 nM
CNCc1ccc(-c2cc3cc(F)cc(C(N)=O)c3o2)cc1 CHEMBL5286956 IC50 3.2 nM
CN(C)Cc1ccc(C2Nc3cc(F)cc4c(=O)[nH]nc(c34)C2c2ccccc2)cc1 CHEMBL3764670 IC50 3.29 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(Cc5ccccc5)CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL590882 IC50 3.3 nM
O=C(c1ccc(I)cc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL3735979 IC50 3.3 nM
CCN(CC)CCn1c2c3c4c(cccc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL3926240 IC50 3.3 nM
O=C1NN=C2CN(C(=O)C3CC3)Cc3[nH]c4cccc1c4c32 CHEMBL3922789 IC50 3.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCCNCC1 CHEMBL380648 IC50 3.4 nM
CCCN1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3917078 EC50 3.4 nM
CCc1cc2ncc(CN3CCC(Nc4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5202261 IC50 3.4 nM
CC(C)(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5419831 IC50 3.45 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(NCC5CC5)CCCCC4)CC3)c2)n[nH]c(=O)c1C CHEMBL605844 IC50 3.5 nM
CN1CCN(CCNC(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL2058693 Ki 3.5 nM
COC(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3905429 Ki 3.5 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(C2CCCCC2)CC1 CHEMBL4173148 IC50 3.5 nM
O=C1NN=C2CN(C(=O)C3(O)CC3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL4784831 EC50 3.5 nM
O=C1NN=C2CCCCc3[nH]c4cc(F)cc1c4c32 CHEMBL3962648 EC50 3.5 nM
CCCNCc1ccc(-c2[nH]c3cc(F)cc4c3c2C(=O)NNC4=O)cc1 CHEMBL3617773 IC50 3.501 nM
CNC1(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c(C)c4C)ccc3F)CC2)CC1 CHEMBL599803 IC50 3.6 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(Cc5ccc(F)cc5)CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL592486 IC50 3.6 nM
CN(C)CCN(C)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3947475 Ki 3.6 nM
O=C1NN=C2CCCc3[nH]c4cccc1c4c32 CHEMBL3891329 EC50 3.6 nM
O=c1[nH]nc2c3c(cccc13)NC(c1ccc(CN3CCC3)cc1)C2c1ccccc1 CHEMBL3763243 IC50 3.63 nM
CN(C)Cc1cccc(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccccc2)c1 CHEMBL3765275 IC50 3.65 nM
CC(C1CCCC1)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5423934 IC50 3.67 nM
CNC(C)(C)C(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c(C)c3C)ccc2F)CC1 CHEMBL599802 IC50 3.7 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCN(C(=O)C2CCCC2)CC1 CHEMBL598544 IC50 3.7 nM
CNC(C)c1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1 CHEMBL1094960 IC50 3.7 nM
CN(C)Cc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1 CHEMBL1096641 IC50 3.7 nM
CCC(C)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5432860 IC50 3.76 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC(F)(F)F CHEMBL5421933 IC50 3.79 nM
CNCc1ccc(-c2cc3cccc4c3n2CCNC4=O)cc1 CHEMBL361447 Ki 3.8 nM
CC1CC(=O)N(c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1=O CHEMBL370838 IC50 3.8 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4noc(=S)[nH]4)cc3)nc12 CHEMBL569636 Ki 3.8 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)[C@]4(C)CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL597926 IC50 3.8 nM
CCC1(C(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c(C)c4C)ccc3F)CC2)CCCN1 CHEMBL592230 IC50 3.8 nM
CNCc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1 CHEMBL609862 IC50 3.8 nM
O=C(O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 CHEMBL3427055 IC50 3.8 nM
CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5408420 IC50 3.81 nM
CCC(CC)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5406119 IC50 3.86 nM
CN(C)Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(CN(C)C)cc2)cc1 CHEMBL3764811 IC50 3.89 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)NCCc3nc4c(C(N)=O)cccc4[nH]3)cc1)C2=O CHEMBL4529965 pIC50 3.89 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(Nc5ccccc5)CCCC4)CC3)c2)n[nH]c(=O)c1C CHEMBL598752 IC50 3.9 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4CCNC4)CC3)c2)n[nH]c(=O)c1C CHEMBL598350 IC50 3.9 nM
O=C(c1cccc(I)c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL3736047 IC50 3.9 nM
Cn1ncnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1ccc(C#N)cc1 CHEMBL3765472 IC50 3.9 nM
CCc1cc2ncc(CN3CCN(c4ccc(F)cn4)CC3)cc2[nH]c1=O CHEMBL5417456 pIC50 3.981 nM
N#Cc1ccc(N2CCN(Cc3cnc4cc(C5CC5)c(=O)[nH]c4c3)CC2)nc1 CHEMBL5440794 pIC50 3.981 nM
N#Cc1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL335993 Ki 4.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CNC1 CHEMBL525192 Ki 4.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCNC1 CHEMBL526668 Ki 4.0 nM
NC(=O)c1cccc2[nH]c(C3CCNC3)nc12 CHEMBL488496 Ki 4.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCNCC1 CHEMBL495942 Ki 4.0 nM
CC(C)N1CCC(c2nc3c(C(N)=O)cccc3[nH]2)C1 CHEMBL450698 EC50 4.0 nM
CC(C)N1CCCC1(C)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL525535 EC50 4.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCN(Cc2ccccc2F)C1 CHEMBL498008 EC50 4.0 nM
C[C@]1(c2nc3c(C(N)=O)cc(Cl)cc3[nH]2)CCCN1 CHEMBL522549 EC50 4.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(CC2CC2)CC1 CHEMBL503239 IC50 4.0 nM
CC(C)N1CCC(c2nc3c(C(N)=O)cccc3[nH]2)CC1 CHEMBL452801 EC50 4.0 nM
CC(C)(NC1CCCC1)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL479780 EC50 4.0 nM
Cc1noc(-c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)n1 CHEMBL579023 Ki 4.0 nM
NC(=O)c1cc(F)cc2cn(-c3ccc(NC(=O)C4CNC4)c(F)c3)nc12 CHEMBL592960 IC50 4.0 nM
CNCc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1F CHEMBL596565 IC50 4.0 nM
CNCc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1OC CHEMBL593828 IC50 4.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)c1ccccc1 CHEMBL596168 IC50 4.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)CCc1ccccc1 CHEMBL596390 IC50 4.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)[C@@H]1CCCN1 CHEMBL610165 IC50 4.0 nM
O=C(c1cc(Cc2c[nH]c(=O)c3c(Cl)cc(Cl)n23)ccc1F)N1CCCNCC1 CHEMBL599595 IC50 4.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCCN4)cc3)nc12 CHEMBL1093900 Ki 4.0 nM
CN1CCCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)C1 CHEMBL1090483 Ki 4.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc([C@H]4CCCN4)cc3F)nc12 CHEMBL1090466 Ki 4.0 nM
CN1CCCC1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1092737 EC50 4.0 nM
CN1CCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)C1 CHEMBL1090582 EC50 4.0 nM
CC(=O)CCCC(=O)Nc1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058686 Ki 4.0 nM
O=C(CCC(=O)c1ccccc1)Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1 CHEMBL3915702 Ki 4.0 nM
O=C(Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)c1ccc2ccccc2c1O CHEMBL3913270 Ki 4.0 nM
CC1(C)CC(=O)N(c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1=O CHEMBL3909998 Ki 4.0 nM
O=CN1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)CC1 CHEMBL3948205 Ki 4.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCN(c2ccccc2F)CC1 CHEMBL3911328 Ki 4.0 nM
CN(C)CCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3928128 Ki 4.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(C(=O)N2CCCCC2)CC1 CHEMBL3981120 Ki 4.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ccc(F)cc2)CC1 CHEMBL3962134 Ki 4.0 nM
O=C(CN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1)N1CCCC1 CHEMBL3959338 Ki 4.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(CCO)CC1 CHEMBL3906970 Ki 4.0 nM
O=C(OCc1ccccc1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3972527 Ki 4.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(CCN2CCOCC2)CC1 CHEMBL3945292 Ki 4.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(CCN2CCOCC2)CC1 CHEMBL3890212 Ki 4.0 nM
CCN(C(C)=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1 CHEMBL3911509 Ki 4.0 nM
Cn1cncc1C(=O)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3960351 Ki 4.0 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCN(C(=O)c2ccncc2)CC1 CHEMBL3974615 Ki 4.0 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCN(C(=O)c2ccco2)CC1 CHEMBL3904816 Ki 4.0 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCN(C(=O)c2cscn2)CC1 CHEMBL3984349 Ki 4.0 nM
O=C(NC1CCN(C(=O)c2ccco2)CC1)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3907439 Ki 4.0 nM
O=C(NC1CCN(C(=O)c2ccccn2)CC1)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3899070 Ki 4.0 nM
CCc1cc2ccc(CN3CCN(c4ccc(C(=O)NC)nn4)CC3)cc2[nH]c1=O CHEMBL5202060 IC50 4.0 nM
CNC(=O)c1ccc(N2CCN(Cc3ccc4cc(C)c(=O)[nH]c4c3F)CC2)c(F)n1 CHEMBL5408653 IC50 4.0 nM
O=c1[nH]nc2c3c(cccc13)NC(c1ccc(CN3CCCC3)cc1)C2c1ccccc1 CHEMBL3763844 IC50 4.02 nM
O=C(Nc1ccc(C(F)(F)F)cc1)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5174447 IC50 4.08 nM
O=C1NCCn2c(-c3ccccc3)nc3cccc1c32 CHEMBL63211 Ki 4.1 nM
O=C1CCCC(=O)N1c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F CHEMBL370217 IC50 4.1 nM
C=CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5395127 IC50 4.18 nM
O=C1NCCn2c(-c3ccc(CO)cc3)nc3cccc1c32 CHEMBL65791 Ki 4.2 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)[C@@]4(Cc5ccc(F)cc5)CCCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL592487 IC50 4.2 nM
O=C(c1ccc2ccccc2n1)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3981249 Ki 4.2 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2cccc(Cl)c2)CC1 CHEMBL4167934 IC50 4.2 nM
COC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1 CHEMBL5176058 IC50 4.2 nM
Nc1ccccc1NC(=O)CCCCCNC(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F CHEMBL4636062 IC50 4.23 nM
CCNCc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1 CHEMBL1094969 IC50 4.3 nM
CN1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3908092 EC50 4.3 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1 CHEMBL5428859 IC50 4.33 nM
CC1(C)CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1O CHEMBL3901638 EC50 4.4 nM
CN(C)Cc1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL81125 Ki 4.5 nM
NC(=O)c1cccc2[nH]c(-c3ccc(CN(CCO)CCO)cc3)nc12 CHEMBL79218 Ki 4.5 nM
Cn1ccc(-c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)n1 CHEMBL578804 Ki 4.5 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCC4(CCCN4C)CC3)c2)n[nH]c(=O)c1C CHEMBL598356 IC50 4.5 nM
C[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5080640 IC50 4.52 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCC4(CCN4)CC3)c2)n[nH]c(=O)c1C CHEMBL604293 IC50 4.6 nM
COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCOc4ccccc4C(N)=O)c(C)c3)nc2c1 CHEMBL5209870 IC50 4.6 nM
CC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5432851 IC50 4.68 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCC4(CCNC4)CC3)c2)n[nH]c(=O)c1C CHEMBL597541 IC50 4.7 nM
COC1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL5196674 IC50 4.7 nM
NC(=O)c1cccc2cn(-c3ccc(CN4CCCC4)cc3)nc12 CHEMBL1096642 IC50 4.8 nM
CC1(C)CC2=NNC(=O)c3c(F)ccc4[nH]c(c2c34)C1 CHEMBL3901034 EC50 4.8 nM
COCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5419161 IC50 4.86 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCc2c(nc(-c3cccc4[nH]ccc34)nc2N2CCOCC2)C1 CHEMBL4593274 pIC50 4.898 nM
O=C1NCCn2c(-c3cccc4ccccc34)nc3cccc1c32 CHEMBL303843 Ki 4.9 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCCC1 CHEMBL3893294 IC50 4.9 nM
CN(C)CCn1c2c3c4c(cccc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL3975917 EC50 4.9 nM
Nc1cc(C(F)(F)F)c(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL4470724 IC50 4.9 nM
CC(C1CCCCC1)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5423161 IC50 4.92 nM
CN(C)Cc1ccc(-c2[nH]c3cccc4c3c2CCNC4=O)cc1 CHEMBL148173 Ki 5.0 nM
O=C1NCCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3cccc1c23 CHEMBL345016 Ki 5.0 nM
O=C1NCCc2c(-c3cccs3)[nH]c3cccc1c23 CHEMBL144084 Ki 5.0 nM
O=C1NCCc2c(-c3cccc4ccccc34)[nH]c3cccc1c23 CHEMBL148367 Ki 5.0 nM
O=C1CCC(=O)N1c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F CHEMBL196444 IC50 5.0 nM
O=C1C2CC2C(=O)N1c1cc(Cc2nnc(O)c3ccccc23)ccc1F CHEMBL436298 IC50 5.0 nM
O=C(c1cc(Cc2nnc(O)c3ccccc23)ccc1F)N1CCCN(CC2CC2)CC1 CHEMBL203967 IC50 5.0 nM
O=C(c1cc(Cc2nnc(O)c3ccccc23)ccc1F)N1CCCN(C2CCCCC2)CC1 CHEMBL204348 IC50 5.0 nM
CCCN1CCCN(C(=O)c2cc(Cc3nnc(O)c4ccccc34)ccc2F)CC1 CHEMBL204809 IC50 5.0 nM
NC(=O)c1cccc2[nH]c(C3CCCNCC3)nc12 CHEMBL488053 Ki 5.0 nM
CCCN1CCCCC1(C)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL445016 EC50 5.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2ccccc2)CC1 CHEMBL494929 IC50 5.0 nM
CCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL494505 IC50 5.0 nM
CCCCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL493693 IC50 5.0 nM
NC(=O)c1cccc2[nH]c(C3CCNCC3)nc12 CHEMBL488052 Ki 5.0 nM
CC(C)N1CCCC(c2nc3c(C(N)=O)cccc3[nH]2)CC1 CHEMBL512213 Ki 5.0 nM
NC(=O)c1cccc2[nH]c(C3CCN(C4CCCC4)CC3)nc12 CHEMBL452025 EC50 5.0 nM
CC(Oc1ccccc1)C(=O)N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4ccccc34)c2)CC1 CHEMBL480704 IC50 5.0 nM
O=c1[nH]c2cc(CN3CCCC3)ccc2n2cccc12 CHEMBL571234 Ki 5.0 nM
NC(=O)c1cc(F)cc2cn(-c3ccc(NC(=O)C4CNC4)cc3)nc12 CHEMBL595695 IC50 5.0 nM
CNCc1ccc(-n2cc3cc(Cl)cc(C(N)=O)c3n2)cc1 CHEMBL596581 IC50 5.0 nM
CNCc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1C(F)(F)F CHEMBL593610 IC50 5.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1ccc(Cl)cc1 CHEMBL594976 IC50 5.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1cccc(Cl)c1 CHEMBL595926 IC50 5.0 nM
COc1cccc(CC(=O)N2CCc3cccc4c3C2CNC4=O)c1 CHEMBL595236 IC50 5.0 nM
CN1CCCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL596720 IC50 5.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2cccc2C1 CHEMBL3928827 IC50 5.0 nM
O=C(NC1CNC1)c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1 CHEMBL3928259 Ki 5.0 nM
O=C(CCC(=O)c1cccs1)Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1 CHEMBL3981743 Ki 5.0 nM
Cc1cnc(C(=O)Nc2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)cn1 CHEMBL3934525 Ki 5.0 nM
CN1CCN(c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1=O CHEMBL3983746 Ki 5.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCC(O)CC1 CHEMBL3952003 Ki 5.0 nM
NC(=O)C1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)CC1 CHEMBL3957216 Ki 5.0 nM
COCCC(=O)Nc1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3903759 Ki 5.0 nM
O=C1CCCN1c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058679 Ki 5.0 nM
COc1ccc(OCC(=O)Nc2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)cc1 CHEMBL3975392 Ki 5.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ccccc2Cl)CC1 CHEMBL3948066 Ki 5.0 nM
NC(=O)C1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)C1 CHEMBL3944092 Ki 5.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ccc(F)cc2F)CC1 CHEMBL3933156 Ki 5.0 nM
O=C(OCc1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3942928 Ki 5.0 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCNCC1 CHEMBL3954828 Ki 5.0 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCN(C(=O)[C@@H]2CSCN2)CC1 CHEMBL3923545 Ki 5.0 nM
CC(C)n1c(C(F)(F)F)nc2cc(C(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6c5CCCC6)ccc4F)CC3)ccc21 CHEMBL3974780 Ki 5.0 nM
N#Cc1ccc(N2CCN([C@@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4777158 IC50 5.0 nM
CC(C)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3907535 EC50 5.0 nM
CCOC(=O)Nc1nc2ccc(-c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)cc2[nH]1 CHEMBL5184668 IC50 5.0 nM
CCc1cc2ccc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5197101 IC50 5.0 nM
CCc1nc2ccc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5188853 IC50 5.0 nM
Cc1nc2c(F)cc(CN3CCN(c4ccc(C(=O)NC5CC5)nc4F)CC3)cc2[nH]c1=O CHEMBL5398856 IC50 5.0 nM
CNC(=O)c1ccc(N2CCN(Cc3cc(F)c4nc(C)c(=O)[nH]c4c3)CC2)c(F)n1 CHEMBL5404994 IC50 5.0 nM
CNC(=O)c1ccc(N2CCN(Cc3cc(F)c4nc(C)c(=O)[nH]c4c3)CC2)c(Cl)n1 CHEMBL5422478 IC50 5.0 nM
CC(C)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5428217 IC50 5.06 nM
CN(C)C(C)(C)C(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL597324 IC50 5.1 nM
CC(C)(C)OC(=O)N1CCC2=C(C1)Nc1cccc3c(=O)[nH]nc2c13 CHEMBL3901232 IC50 5.1 nM
N#Cc1cccc(N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)cc(F)c3F)CC2)n1 CHEMBL4163384 IC50 5.1 nM
NC(=O)c1ccccc1NCc1cccc(NC(=O)Nc2cccc(Br)c2)c1 CHEMBL5417544 IC50 5.17 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4nsc(=O)[nH]4)cc3)nc12 CHEMBL583526 Ki 5.2 nM
CC1(C)CCc2[nH]c3cc(F)cc4c3c2C1=NNC4=O CHEMBL3914932 IC50 5.2 nM
Cn1ccnc1C1c2n[nH]c(=O)c3cccc(c23)NC1c1ccc(C(F)(F)F)cc1 CHEMBL3763963 IC50 5.27 nM
CNCc1cccc(-n2cc3cccc(C(N)=O)c3n2)c1 CHEMBL1095605 IC50 5.3 nM
COc1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1OC CHEMBL133343 Ki 5.4 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCC(N2CCCC2)CC1 CHEMBL589833 IC50 5.4 nM
N#Cc1ccc(N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)cc(F)c3F)CC2)cc1 CHEMBL4160677 IC50 5.4 nM
CC(C)n1cc2c(n1)CN(C(=O)c1cc(Cc3n[nH]c(=O)c4ccccc34)ccc1F)C2 CHEMBL4554200 IC50 5.4 nM
CCc1cc2ncc(CN3CCN(c4cc5c(cn4)NC(=O)CC5)CC3)cc2[nH]c1=O CHEMBL5201927 IC50 5.4 nM
O=C1NN=C2CCCc3[nH]c4cc(F)cc1c4c32 CHEMBL3929705 EC50 5.5 nM
CN(C)Cc1cccc(-c2nc3c(C(N)=O)cccc3[nH]2)c1 CHEMBL82434 Ki 5.6 nM
O=c1[nH]nc2c3c(cccc13)N[C@@H](c1ccc(CN3CCC3)cc1)[C@@H]2c1ccc(F)cc1 CHEMBL3765670 IC50 5.6 nM
N#Cc1ccc(N2CCN([C@@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)c(F)c1 CHEMBL4776507 IC50 5.6 nM
O=C1NCCC2=C(c3ccc(CN4CCCC4)cc3)Cc3cccc1c32 CHEMBL5284183 Ki 5.6 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(C(F)(F)CO)o2)C1 CHEMBL5417924 IC50 5.67 nM
O=C1NCCn2c(-c3ccc(Cl)cc3)nc3cccc1c32 CHEMBL69407 Ki 5.7 nM
Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)C4(N(C)C)CC4)CC3)c2)n[nH]c(=O)c1C CHEMBL591528 IC50 5.7 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(CC2CC2)C1 CHEMBL4061458 IC50 5.7 nM
C[C@]1(c2nc3c(C(N)=O)c(F)ccc3[nH]2)CCCN1 CHEMBL4447698 IC50 5.7 nM
CN(C)c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL334357 Ki 5.8 nM
CN(C)Cc1ccc(-c2nc3cccc4c3n2CCNC4=O)cc1 CHEMBL65892 Ki 5.8 nM
O=C(Cc1cccc(I)c1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL3735832 IC50 5.8 nM
O=C1NN=C2CC(c3ccccc3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL3900548 IC50 5.8 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(c4nc(-c5cnc(N)nc5)nc(N5CCOCC5)n4)CC3)oc12 CHEMBL4744783 IC50 5.8 nM
CN(C)Cc1ccc(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccccc2)cc1 CHEMBL3764640 IC50 5.85 nM
NC(=O)c1cccc2[nH]c(-c3ccc4c(c3)OCO4)nc12 CHEMBL337386 Ki 5.9 nM
COc1ccc(CN(C)c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)cc1 CHEMBL83971 Ki 5.9 nM
NC(=O)c1cccc2[nH]c(-c3ccc(CN4CCCC4)cc3)nc12 CHEMBL312135 Ki 5.9 nM
CN(C)CCN(C)Cc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1 CHEMBL1094968 IC50 5.9 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCCCC1 CHEMBL3939501 IC50 5.9 nM
C[C@]12CCC=C(CO)C1=CC1C(C2)OC(=O)C1CNCCOCCOCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL5185640 IC50 5.91 nM
O=C1NCCc2c(-c3cccc(C(F)(F)F)c3)[nH]c3cccc1c23 CHEMBL439984 Ki 6.0 nM
COc1ccc(-c2[nH]c3cccc4c3c2CCNC4=O)cc1 CHEMBL144024 Ki 6.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(O)cc3)nc12 CHEMBL131719 Ki 6.0 nM
O=C1NCCc2c(-c3ccccc3)[nH]c3cccc1c23 CHEMBL147663 Ki 6.0 nM
COc1cccc(-c2nc3c(C(N)=O)cccc3[nH]2)c1 CHEMBL134022 Ki 6.0 nM
O=C1NCCc2c(-c3ccc(Cn4cccc4)cc3)[nH]c3cccc1c23 CHEMBL148334 Ki 6.0 nM
N#Cc1ccc(C2=CCN(CCCc3nc(O)c4ccccc4n3)CC2)cc1 CHEMBL185742 IC50 6.0 nM
O=C1NCCn2c(-c3ccc(F)cc3)c(/C=N/O)c3cccc1c32 CHEMBL363893 Ki 6.0 nM
O=C(c1cccc(Cc2nnc(O)c3ccccc23)c1)N1CCCN(C2CCCCC2)CC1 CHEMBL203548 IC50 6.0 nM
O=C(c1cccc(Cc2nnc(O)c3ccccc23)c1)N1CCCN(S(=O)(=O)c2ccc(-c3ccccc3)cc2)CC1 CHEMBL372778 IC50 6.0 nM
NC(=O)c1cccc2[nH]c(C3CNC3)nc12 CHEMBL527654 Ki 6.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCCN1C1CCC1 CHEMBL497597 EC50 6.0 nM
O=C(c1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL493306 IC50 6.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)N2CCOCC2)CC1 CHEMBL494721 IC50 6.0 nM
CC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL495322 IC50 6.0 nM
CCCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL493692 IC50 6.0 nM
CCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL492692 IC50 6.0 nM
NC(=O)c1cccc2[nH]c(C3CCN(CCc4ccccc4)C3)nc12 CHEMBL453060 EC50 6.0 nM
CN1CC(C(=O)Nc2ccc(-n3cc4cc(F)cc(C(N)=O)c4n3)cc2F)C1 CHEMBL605929 IC50 6.0 nM
CN1CC(C(=O)Nc2ccc(-n3cc4cc(F)cc(C(N)=O)c4n3)cc2)C1 CHEMBL595925 IC50 6.0 nM
CNCc1ccc(-n2cc3cc(F)cc(C(N)=O)c3n2)c(F)c1 CHEMBL594836 IC50 6.0 nM
COc1ccc(CC(=O)N2CCc3cccc4c3C2CNC4=O)cc1 CHEMBL595928 IC50 6.0 nM
Cc1csc(CC(=O)N2CCc3cccc4c3C2CNC4=O)n1 CHEMBL595019 IC50 6.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)CCc1cnccn1 CHEMBL609002 IC50 6.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)CN1CCCCC1 CHEMBL611322 IC50 6.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCCN4)cc3F)nc12 CHEMBL1089101 Ki 6.0 nM
NC(=O)c1cccc2nc(-c3ccc([C@@H]4CCCCN4)cc3F)[nH]c12 CHEMBL1089125 Ki 6.0 nM
CC(C)N1CCCC1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1093898 EC50 6.0 nM
CN1CCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)CC1 CHEMBL1093012 EC50 6.0 nM
CCNC(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058690 Ki 6.0 nM
CN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL2058914 Ki 6.0 nM
CCNC(=O)c1ccc(N2CCN(Cc3cc(C)c4c(c3)NC(=O)C(C)O4)CC2)cc1 CHEMBL2407975 IC50 6.0 nM
O=c1[nH]nc2c3c(cccc13)N=C(CN1CC=C(c3ccc(F)cc3)CC1)N2 CHEMBL3644564 IC50 6.0 nM
CN(C)C1(C(=O)N2CCN(C(=O)c3cc(Oc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)CC1 CHEMBL3924658 IC50 6.0 nM
CC(C)C1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3907218 IC50 6.0 nM
O=c1[nH]nc(Cc2ccc(F)c(-c3ncccn3)c2)c2c1CCCC2 CHEMBL3986952 Ki 6.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCC(c2ccccc2)CC1 CHEMBL3907189 Ki 6.0 nM
O=C(Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)C1CNC1 CHEMBL3979663 Ki 6.0 nM
O=C(CCOc1ccccc1)Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1 CHEMBL3933621 Ki 6.0 nM
O=C1OCCN1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3897400 Ki 6.0 nM
O=C1CCN1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3908331 Ki 6.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL3965763 Ki 6.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCN(c2ccc(F)cc2)CC1 CHEMBL3938218 Ki 6.0 nM
CCN(CC)C(=O)C1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1 CHEMBL3935109 Ki 6.0 nM
CN(C)CCN(C)C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3897939 Ki 6.0 nM
CC(=O)N(C)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)C1 CHEMBL3968163 Ki 6.0 nM
CCN(C(C)=O)C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)C1 CHEMBL3897004 Ki 6.0 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCC1 CHEMBL3978133 IC50 6.0 nM
COc1ccc(-c2[nH]c(=O)c3cc(F)ccc3c2OCCN)cc1F CHEMBL3910271 IC50 6.0 nM
NC(=O)c1ccccc1OCc1cccc(NC(=O)Nc2cccc(Br)c2)c1 CHEMBL5407016 IC50 6.06 nM
O=c1[nH]nc2c3c(cccc13)NC(c1ccccc1)C2c1ccccc1 CHEMBL3763589 IC50 6.1 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCC1 CHEMBL3952089 IC50 6.1 nM
O=C(c1ccccc1)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)cc(F)c2F)CC1 CHEMBL4163596 IC50 6.1 nM
CC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5081000 IC50 6.1 nM
CC(C)C(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5093731 IC50 6.15 nM
O=C(NO)c1ccc(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL4097093 IC50 6.16 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCc2c(nc(-c3cccc4[nH]ncc34)nc2N2CCOCC2)C1 CHEMBL4531016 pIC50 6.166 nM
Cn1ccnc1C1c2n[nH]c(=O)c3cc(Cl)cc(c23)NC1c1ccccc1 CHEMBL3763370 IC50 6.18 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(C3COC3)o2)C1 CHEMBL5423216 IC50 6.19 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCC2(CCCCN2)CC1 CHEMBL601260 IC50 6.2 nM
CC(C)(C)OC(=O)N1CC[C@H](C(=O)Nc2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2Cl)C1 CHEMBL4082114 IC50 6.2 nM
CN(C)Cc1ccc(C2Nc3cccc4c(=O)[nH]nc(c34)C2c2ccc(C(F)(F)F)cc2)cc1 CHEMBL3763661 IC50 6.29 nM
NC(=O)c1cccc2[nH]c(-c3cccc(O)c3)nc12 CHEMBL336070 Ki 6.3 nM
CN(C)Cc1cccc(-c2nc3cccc4c3n2CCNC4=O)c1 CHEMBL417036 Ki 6.3 nM
CC(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL602535 IC50 6.3 nM
O=C1NCCn2c(-c3ccc(OCCF)cc3)nc3cccc1c32 CHEMBL3113568 IC50 6.3 nM
O=C1NN=C2CC(c3ccccc3)Cc3[nH]c4cccc1c4c32 CHEMBL3892363 IC50 6.3 nM
CC1(C)CCC2=C(C1)c1n[nH]c(=O)c3cccc(c13)N2 CHEMBL3955370 IC50 6.3 nM
Cn1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)n1 CHEMBL5436154 IC50 6.34 nM
CC1=CSC(NNS(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)N1C(=O)c1ccccc1 CHEMBL5435531 IC50 6.35 nM
CN(C)Cc1ccc(-c2cc3cccc4c3n2CCNC4=O)cc1 CHEMBL361489 Ki 6.4 nM
CC1(C)CC2=NNC(=O)c3cccc4c3c2c(n4CCN2CCCC2)C1 CHEMBL3947623 IC50 6.6 nM
O=C1NN=C2CN(C(=O)[C@@H]3CCCN3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL4749094 IC50 6.6 nM
CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2C(=O)NNC4=O)cc1 CHEMBL3617772 IC50 6.643 nM
CC(C)NCc1ccc(-n2cc3cccc(C(N)=O)c3n2)cc1 CHEMBL1094959 IC50 6.7 nM
NC(=O)c1cccc2[nH]c(-c3cccc(CO)c3)nc12 CHEMBL337254 Ki 6.8 nM
COc1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL131820 Ki 6.8 nM
O=C1NCCn2c(-c3ccc(Cn4cccc4)cc3)cc3cccc1c32 CHEMBL188989 Ki 6.8 nM
O=C1CC(c2ccccc2)C(=O)N1c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F CHEMBL196450 IC50 6.8 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4cn5ccc(C(F)(F)F)cc5n4)cc3)nc12 CHEMBL569635 Ki 6.8 nM
CC(C)C(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1C CHEMBL5080271 IC50 6.88 nM
CNCc1cccc(-c2cc3cccc4c3n2CCNC4=O)c1 CHEMBL362111 Ki 6.9 nM
Cn1nc(-c2cccs2)c2c3c(c(=O)[nH]c21)CCCC3 CHEMBL497571 IC50 6.9 nM
O=C1NN=C2CNCc3[nH]c4cccc1c4c32 CHEMBL3970120 EC50 6.9 nM
Nc1cccc(-c2[nH]c3cccc4c3c2CCNC4=O)c1 CHEMBL343263 Ki 7.0 nM
Cn1c(-c2ccccc2)c2c3c(cccc31)C(=O)NCC2 CHEMBL144009 Ki 7.0 nM
O=C1NCCc2c(-c3cccnc3)[nH]c3cccc1c23 CHEMBL343665 Ki 7.0 nM
CCN1CCCN(C(=O)c2cc(Cc3nnc(O)c4ccccc34)ccc2F)CC1 CHEMBL426116 IC50 7.0 nM
NC(=O)c1cccc2[nH]c([C@H]3CCCN3)nc12 CHEMBL488830 Ki 7.0 nM
CCC1(c2nc3c(C(N)=O)cccc3[nH]2)CCCN1 CHEMBL507412 EC50 7.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCCN(CCO)CC1 CHEMBL523887 IC50 7.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)c1ccc(Cl)cc1 CHEMBL611049 IC50 7.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1ccc(Br)cc1 CHEMBL594521 IC50 7.0 nM
CC(C)N1CCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)CC1 CHEMBL1092224 Ki 7.0 nM
CC(C)N1CCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)C1 CHEMBL1093899 EC50 7.0 nM
O=C(CN1CCC[C@H]1C(=O)O)c1ccc2[nH]c3c4c(c5c(c3c2c1)C(=O)NC5=O)CCC4 CHEMBL1935261 IC50 7.0 nM
CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)CCC(=O)c1ccc2[nH]c3c4c(c5c(c3c2c1)C(=O)NC5=O)CCC4 CHEMBL1935273 IC50 7.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCNC[C@H]1c1ccccc1 CHEMBL2058913 Ki 7.0 nM
CN(C)C1(C(=O)N2CCN(C(=O)c3cc(Oc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)CCC1 CHEMBL4106657 IC50 7.0 nM
C[C@H]1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(C(F)(F)F)n21 CHEMBL3961901 IC50 7.0 nM
O=C1NN=C2CN(C(=O)OCc3ccccc3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL3933450 IC50 7.0 nM
O=C(Nc1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)c1ccc(O)nc1 CHEMBL3944561 Ki 7.0 nM
O=C1[C@@H]2CCC(C2)N1c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL4107630 Ki 7.0 nM
CN(C)CCN1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)CC1 CHEMBL3982506 Ki 7.0 nM
CN(C(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)C1CCN(C(=O)c2cccnc2)CC1 CHEMBL3932639 Ki 7.0 nM
CCN(CCN)C(=O)c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F CHEMBL3941603 Ki 7.0 nM
O=C(NC1CCN(C(=O)c2cccnc2)CC1)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3890001 Ki 7.0 nM
O=C(/C=C/c1ccc(CCCCCCc2n[nH]c(=O)c3cc(F)ccc23)cc1)NO CHEMBL5179574 IC50 7.0 nM
O=c1[nH]c(CCCN2CCN(c3ccc(F)cc3F)CC2)nc2c(Cl)cccc12 CHEMBL5190481 IC50 7.0 nM
NC1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL604547 IC50 7.1 nM
CC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)cc(F)c2F)CC1 CHEMBL4170845 IC50 7.1 nM
CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(CF)n21 CHEMBL3936349 IC50 7.15 nM
NC(=O)c1cccc2[nH]c(-c3ccc(CN4CCCCC4)cc3)nc12 CHEMBL419475 Ki 7.2 nM
CN(C)C(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL589575 IC50 7.2 nM
CC1(C(=O)N2CCC3=C(C2)Nc2cccc4c(=O)[nH]nc3c24)CC1 CHEMBL3905682 IC50 7.2 nM
NC(=O)c1cc(Cl)c2cc(-c3cc4c(s3)CCNC4)cnn12 CHEMBL4758651 IC50 7.24 nM
Cn1nc(-c2ccccc2)c2c1NC(=O)C1CCCCC21 CHEMBL525167 IC50 7.3 nM
CC(C)(C)C(=O)N1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3906623 IC50 7.3 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(c4nc(-c5cnc(N)cc5C(F)(F)F)nc(N5CCOCC5)n4)CC3)oc12 CHEMBL4758337 IC50 7.3 nM
Cn1cc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL5436989 IC50 7.32 nM
O=c1[nH]nc2c3c(cccc13)NC(c1ccc(F)cc1)C2c1nccs1 CHEMBL3764464 IC50 7.35 nM
O=C1NCCn2c(-c3ccc(Cl)cc3)c(/C=N/O)c3cccc1c32 CHEMBL186461 Ki 7.5 nM
NC(=O)c1cc(F)cc2[nH]c(C(=O)N3CCC(NC4CCCCC4)CC3)nc12 CHEMBL4098745 IC50 7.54 nM
CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5413070 IC50 7.59 nM
CC1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3915929 IC50 7.6 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCNC1 CHEMBL3978225 IC50 7.6 nM
CC1(C)CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1=O CHEMBL3961684 EC50 7.6 nM
Cn1ncnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1c1cncnc1 CHEMBL3765661 IC50 7.62 nM
O=C1NCCn2c(-c3ccccc3Cl)nc3cccc1c32 CHEMBL304195 Ki 7.7 nM
Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL4551630 pIC50 7.943 nM
O=C1NCCc2c(-c3ccc[nH]3)[nH]c3cccc1c23 CHEMBL344741 Ki 8.0 nM
O=C1NCCc2c(-c3ccccc3Cl)[nH]c3cccc1c23 CHEMBL423573 Ki 8.0 nM
NC(=O)c1cccc2[nH]c(-c3cccc(C(F)(F)F)c3)nc12 CHEMBL335516 Ki 8.0 nM
CN(C)Cc1cccc(-c2[nH]c3cccc4c3c2CCNC4=O)c1 CHEMBL146943 Ki 8.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc([N+](=O)[O-])cc3)nc12 CHEMBL339167 Ki 8.0 nM
COc1ccc(NC(=O)N2CCCN(C(=O)c3cccc(Cc4nnc(O)c5ccccc45)c3)CC2)cc1 CHEMBL204862 IC50 8.0 nM
COc1cccc(CCC(=O)N2CCCN(C(=O)c3cccc(Cc4nnc(O)c5ccccc45)c3)CC2)c1 CHEMBL383070 IC50 8.0 nM
CC1CCN(C(=O)C2CCN(C(=O)c3cccc(Cc4nnc(O)c5ccccc45)c3)CC2)CC1 CHEMBL204097 IC50 8.0 nM
O=C(c1cccc(Cc2nnc(O)c3ccccc23)c1)N1CCc2ccccc2C1 CHEMBL201869 IC50 8.0 nM
O=C(c1cccc(Cc2nnc(O)c3ccccc23)c1)N1CCCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1 CHEMBL382744 IC50 8.0 nM
O=C(NCCc1cccs1)C1CCN(C(=O)c2cccc(Cc3nnc(O)c4ccccc34)c2)CC1 CHEMBL202833 IC50 8.0 nM
Cc1cccc2c(=O)[nH]c(CCCN3CC=C(c4ccc(F)cc4)CC3)nc12 CHEMBL401843 IC50 8.0 nM
CC(C)N1CCC(C)(c2nc3c(C(N)=O)cccc3[nH]2)CC1 CHEMBL495951 Ki 8.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1)N1CCN(C(=O)N2CCOCC2)CC1 CHEMBL492470 IC50 8.0 nM
CCS(=O)(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL493499 IC50 8.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCCN(C(=O)N2CCOCC2)CC1 CHEMBL494874 IC50 8.0 nM
CN1CCC[C@@H]1c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL511050 Ki 8.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1)N1CCN(C(=O)C2CCCC2)CC1 CHEMBL481881 IC50 8.0 nM
CNCc1ccc(-n2cc3c(F)ccc(C(N)=O)c3n2)cc1 CHEMBL593853 IC50 8.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1ccccc1 CHEMBL596389 IC50 8.0 nM
CC(C)N1CCCCC1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1089474 EC50 8.0 nM
CN(CC(=O)O)CC(=O)c1ccc2[nH]c3c4c(c5c(c3c2c1)C(=O)NC5=O)CCC4 CHEMBL1935258 IC50 8.0 nM
O=C(c1ccc2[nH]c(=O)c3c(c2c1)CCSC3)N1CCNCC1 CHEMBL2237228 IC50 8.0 nM
CCC(CC)C(=O)N1CCN(C(=O)c2cc(Oc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL3970441 IC50 8.0 nM
CN1CCN(CCC(=O)Nc2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1 CHEMBL3932307 Ki 8.0 nM
CC1(C)O[C@@H]2[C@H](O1)[C@@H]1C[C@H]2N(c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)C1=O CHEMBL3912520 Ki 8.0 nM
O=C(c1cccc(Cc2n[nH]c(=O)c3c2CCCC3)c1)N1CCN(CCO)CC1 CHEMBL3954628 Ki 8.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F)N1CCN(CCN2CCCCC2)CC1 CHEMBL3959274 Ki 8.0 nM
CC(C)(C)OC(=O)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)C1 CHEMBL3889865 Ki 8.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2cccc(C(F)(F)F)c2)CC1 CHEMBL3981541 Ki 8.0 nM
O=C(NC1CCN(c2ccccn2)CC1)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3950401 Ki 8.0 nM
CC1(C)C(C(=O)N2CCC3=C(C2)Nc2cccc4c(=O)[nH]nc3c24)C1(C)C CHEMBL3893271 IC50 8.0 nM
Cc1c(-c2nc3c(C(N)=O)cc(F)cc3[nH]2)sc2c1CCNC2 CHEMBL4291682 IC50 8.0 nM
O=C1NN=C2CNCc3[nH]c4cc(F)cc1c4c32 CHEMBL3931542 EC50 8.0 nM
O=C1NN=C2CN(S(=O)(=O)C3CC3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL4749300 IC50 8.0 nM
CCc1cc2ccc(CN3CCN(c4ccc(F)cc4F)CC3)cc2[nH]c1=O CHEMBL5196187 IC50 8.0 nM
CCc1cc2ccc(CN3CCN(c4cnc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5183769 IC50 8.0 nM
CCOC(=O)c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL133855 Ki 8.1 nM
CNCC(F)(F)c1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 CHEMBL5433982 IC50 8.15 nM
CCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5088800 IC50 8.17 nM
COc1ccc(-c2cc3cccc4c3n2CCNC4=O)cc1 CHEMBL426618 Ki 8.2 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCC2(CCN2)CC1 CHEMBL590088 IC50 8.2 nM
COC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1 CHEMBL5185911 IC50 8.2 nM
CC(=O)C1=C(C)N(C(=O)c2ccccc2)C(NNS(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)S1 CHEMBL5411930 IC50 8.25 nM
COc1ccc(C2=CCN(CCCc3nc(O)c4ccccc4n3)CC2)cc1 CHEMBL365077 IC50 8.3 nM
CCCN1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3930740 IC50 8.3 nM
C[C@H]1CCC[C@]2(C)CC3OC(=O)C(CNCCCC(=O)N4CCN(C(=O)c5cc(Cc6n[nH]c(=O)c7ccccc67)ccc5F)CC4)C3C=C12 CHEMBL5192888 IC50 8.33 nM
NC(=O)c1cccc2[nH]c(-c3cccc(Cl)c3)nc12 CHEMBL132947 Ki 8.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2C2CC2)C1 CHEMBL4547590 IC50 8.41 nM
NCC(F)(F)c1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 CHEMBL5427638 IC50 8.49 nM
O=C(CCn1c2c(c(=O)[nH]c1=O)CSCC2)NCC(=O)c1ccc2ccccc2c1 CHEMBL323488 IC50 8.5 nM
NC(=O)c1cc(F)cc2c1C(=O)N(C1CCN(C3CCC(F)(F)CC3)CC1)C2 CHEMBL3606021 Kd 8.6 nM
CN1CCN(Cc2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)CC1 CHEMBL81831 Ki 8.7 nM
O=c1[nH]c(C2=C[C@@H](N3CCC(c4ccccc4)CC3)CC2)nc2c(Cl)cccc12 CHEMBL248648 IC50 8.7 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCN(Cc2ccccc2)C1 CHEMBL3939375 IC50 8.7 nM
Cc1cc(O)nn1S(=O)(=O)c1ccc2[nH]c(=O)c(=O)[nH]c2c1 CHEMBL5428997 IC50 8.73 nM
O=C1NCCn2c(-c3cccc(CO)c3)nc3cccc1c32 CHEMBL432146 Ki 8.8 nM
Nc1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCN(C(=O)c5cc(Cc6n[nH]c(=O)c7ccccc67)ccc5F)CC4)cc3n2)cn1 CHEMBL4848869 IC50 8.8 nM
COC(=O)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5421189 IC50 8.88 nM
O=c1[nH]c(CCCN2CC=C(c3ccc(F)cc3)CC2)nc2ccccc12 CHEMBL251027 IC50 8.9 nM
O=C1NC(CCCN2CC=C(c3ccccc3)CC2)=NC2CCSCC12 CHEMBL195758 IC50 8.9 nM
O=c1[nH]c(CCCN2CC=C(c3ccc(Cl)cc3)CC2)nc2ccccc12 CHEMBL251028 IC50 8.9 nM
O=C1NN=C2CN(C(=O)OCc3ccccc3)Cc3[nH]c4cccc1c4c32 CHEMBL3955609 IC50 8.9 nM
NC(=O)c1cccc2[nH]c(-c3ccccc3F)nc12 CHEMBL133353 Ki 9.0 nM
O=C1NCCc2c(-c3ccc4[nH]ccc4c3)[nH]c3cccc1c23 CHEMBL357149 Ki 9.0 nM
O=C(CCCN1CCOCC1)Nc1ccc2c(c1)Cc1c-2nc(O)c2ccccc12 CHEMBL191185 EC50 9.0 nM
O=S(=O)(NCCCN1CCOCC1)c1cc2c(cc1F)-c1nc(O)c3ccccc3c1C2 CHEMBL365086 EC50 9.0 nM
CN1CCCN(C(=O)c2cc(Cc3nnc(O)c4ccccc34)ccc2F)CC1 CHEMBL202758 IC50 9.0 nM
COc1cc(C(=O)N2CCCN(C(=O)c3cccc(Cc4nnc(O)c5ccccc45)c3)CC2)cc(Cl)n1 CHEMBL204866 IC50 9.0 nM
CN(Cc1ccccc1)C(=O)C1CCN(C(=O)c2cccc(Cc3nnc(O)c4ccccc34)c2)CC1 CHEMBL203765 IC50 9.0 nM
O=C(c1cccc(Cc2nnc(O)c3ccccc23)c1)N1CCCNCC1 CHEMBL201913 IC50 9.0 nM
CCC(C)CN(C)C(=O)C1CCN(C(=O)c2cccc(Cc3nnc(O)c4ccccc34)c2)CC1 CHEMBL201981 IC50 9.0 nM
CN1CCC(c2nc3c(C(N)=O)cccc3[nH]2)CC1 CHEMBL454180 EC50 9.0 nM
CC(C)N1CCC(c2nc3c(C(N)=O)cc(Cl)cc3[nH]2)CC1 CHEMBL460261 EC50 9.0 nM
CC(C)(NCCc1ccccc1)c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL482055 EC50 9.0 nM
O=c1[nH]c2cc(CN3CCCCC3)ccc2n2cccc12 CHEMBL556241 Ki 9.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)Oc1ccccc1 CHEMBL595693 IC50 9.0 nM
N#Cc1ccc(CC(=O)N2CCc3cccc4c3C2CNC4=O)cc1 CHEMBL611621 IC50 9.0 nM
CN(C)C(=O)CCC(=O)N1CCc2cccc3c2C1CNC3=O CHEMBL595680 IC50 9.0 nM
O=C(c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F)N1CCC2(CC1)NCNC2=O CHEMBL590579 IC50 9.0 nM
CCS(=O)(=O)N1CCN(C(=O)c2cc(Cc3c[nH]c(=O)c4cc(Cl)c(Cl)n34)ccc2F)CC1 CHEMBL597925 IC50 9.0 nM
NC(=O)c1cc(Cl)cc2[nH]c(-c3ccc(C4CCCN4)cc3)nc12 CHEMBL1092226 Ki 9.0 nM
NC(=O)c1cccc2cn(-c3ccc(C4CCNCC4)cc3)nc12 CHEMBL1098299 IC50 9.0 nM
Oc1nccc2ccccc12 CHEMBL339695 IC50 9.0 nM
O=C(CCC(=O)c1ccc2[nH]c3c4c(c5c(c3c2c1)C(=O)NC5=O)CCC4)NCCO CHEMBL1935272 IC50 9.0 nM
CC1NC(=O)N(c2cc(Cc3n[nH]c(=O)c4c3NCCC4)ccc2F)C1=O CHEMBL2058683 Ki 9.0 nM
O=C(NCCN1CCCC1)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL2058692 Ki 9.0 nM
O=c1[nH]nc2c3c(cccc13)N=C(CN1CCN(c3ccc(Cl)cc3)CC1)N2 CHEMBL3644565 IC50 9.0 nM
O=C(c1cc(Oc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)N2CCCCC2)CC1 CHEMBL3921646 IC50 9.0 nM
Cc1c(C(=O)Nc2cccc(Cc3n[nH]c(=O)c4c3CCCC4)c2)cnn1-c1ccccc1 CHEMBL3898342 Ki 9.0 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(Cc2cccc(Cl)c2)CC1 CHEMBL3958068 Ki 9.0 nM
O=C(NC1CCN(C(=O)c2cn[nH]c2)CC1)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F CHEMBL3939957 Ki 9.0 nM
Cc1cnc(N2CCN(CCCc3nc4c(Cl)cccc4c(=O)[nH]3)CC2)n1C CHEMBL5193246 IC50 9.0 nM
Cc1cnc(N2CCN(Cc3ccc4c(c3)[nH]c(=O)c3ccccc34)CC2)n1C CHEMBL5191396 IC50 9.0 nM
Cc1cnc(N2CCN(Cc3ccc4c5c(c(=O)[nH]c4c3)CCCC5)CC2)n1C CHEMBL5177596 IC50 9.0 nM
CC(C)C(C)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5434732 IC50 9.0 nM
CCC(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1CC CHEMBL5088601 IC50 9.01 nM
CN(C)Cc1cccc(-c2cc3cccc4c3n2CCNC4=O)c1 CHEMBL188728 Ki 9.1 nM
C/C(=N/O)c1c(-c2ccc(F)cc2)n2c3c(cccc13)C(=O)NCC2 CHEMBL362322 Ki 9.1 nM
C/C(=N\O)c1c(-c2ccc(F)cc2)n2c3c(cccc13)C(=O)NCC2 CHEMBL2204335 Ki 9.1 nM
CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1 CHEMBL372303 IC50 9.1 nM
Cc1c(CN2CCN(C(=O)c3cc4cccc(C(N)=O)c4o3)CC2)sc2c(N3CCOCC3)nc(-c3ccc(N)c(F)c3)nc12 CHEMBL4859625 IC50 9.18 nM
O=C1NN=C2CN(C3CCCCC3)Cc3[nH]c4cccc1c4c32 CHEMBL3978425 IC50 9.2 nM
CCc1cc2cc(C(CCN3CCCCC3)Cc3ccc4c(c3)OCCO4)ccc2[nH]c1=O CHEMBL1171298 pIC50 9.204 nM
O=c1[nH]c(SCCN2CCN(c3ccccn3)CC2)nc2ccccc12 CHEMBL4460557 IC50 9.3 nM
C=CCOc1cc(-c2nc3c(C(N)=O)cccc3[nH]2)ccc1OC CHEMBL134116 Ki 9.4 nM
NC(=O)c1cccc2[nH]c(-c3ccccc3Cl)nc12 CHEMBL335226 Ki 9.4 nM
O=C1NCCn2cc(/C=N/O)c3cccc1c32 CHEMBL189698 Ki 9.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3cc(O)ccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL5440303 IC50 9.43 nM
Cn1ccnc1C1Nc2cccc3c(=O)[nH]nc(c23)C1c1ccccc1 CHEMBL3765357 IC50 9.45 nM
CN1CC(=O)N(c2cc(Cc3nnc(O)c4ccccc34)ccc2F)C(=O)C1 CHEMBL195966 IC50 9.5 nM
Nc1cc(C(F)(F)F)c(-c2nc(N3CCOCC3)nc(N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)n2)cn1 CHEMBL4541731 pIC50 9.55 nM
CC(C)c1ccc(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccc(CN(C)C)cc2)cc1 CHEMBL3763164 IC50 9.59 nM
CCN1CCCC12CCN(C(=O)c1cc(Cc3n[nH]c(=O)c(C)c3C)ccc1F)CC2 CHEMBL598357 IC50 9.7 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(CC2CC2)CC1 CHEMBL4176518 IC50 9.7 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5419639 IC50 9.75 nM
O=c1[nH]nc(Cc2ccccc2)c2c(O)cccc12 CHEMBL5417243 IC50 9.76 nM
CN1CCN(Cc2cccc(-c3nc4c(C(N)=O)cccc4[nH]3)c2)CC1 CHEMBL312719 Ki 9.8 nM
CC1(C)CC(=O)N(c2cc(Cc3nnc(O)c4ccccc34)ccc2F)C1=O CHEMBL197192 IC50 9.8 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(C(=O)c2cccs2)CC1 CHEMBL3105402 IC50 9.8 nM
CC1(C(=O)N2CC3=NNC(=O)c4cc(F)cc5[nH]c(c3c45)C2)CC1 CHEMBL4784468 IC50 9.8 nM
CC(C)=CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5400153 IC50 9.85 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CC(=O)N2CCCCC2C1 CHEMBL5414478 IC50 9.85 nM
O=C(Nc1cncc(Cn2c(=O)[nH]c(=O)c3ccccc32)c1)[C@H]1CCNC1 CHEMBL4084234 IC50 9.9 nM
NC1(C(=O)N2CC3=NNC(=O)c4cc(F)cc5[nH]c(c3c45)C2)CC1 CHEMBL4748572 IC50 9.9 nM
O=c1[nH]c(NCCN2CCN(c3n[nH]c4ccccc34)CC2)nc2ccccc12 CHEMBL1171304 pIC50 9.931 nM