O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 CHEMBL5402698 IC50 0.001 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL521686 IC50 0.1 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CCCC1 CHEMBL5397373 IC50 0.1 nM
C[C@]12CCCN1CC1=NNC(=O)c3cc(F)cc4[nH]c2c1c34 CHEMBL4112930 IC50 0.11 nM
CC1(C)CC2=NNC(=O)c3cccc4c3c2c(n4CCN2CCCCC2)C1 CHEMBL3984980 IC50 0.2 nM
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1 CHEMBL3137320 IC50 0.2 nM
CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(C(F)(F)F)n21 CHEMBL3907010 IC50 0.22 nM
CC(C1CCCC1)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5423934 IC50 0.22 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CCCCC1 CHEMBL5421335 IC50 0.24 nM
CC(C1CCCCC1)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5423161 IC50 0.26 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(C2CCCC2)C(=O)C1 CHEMBL5439635 IC50 0.29 nM
O=C1NN=C2CN(C(=O)OCc3ccccc3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL3933450 IC50 0.3 nM
CCN(CC)CCn1c2c3c4c(cccc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL3926240 IC50 0.3 nM
O=C1NN=C2CN(C(=O)C3CC3)Cc3[nH]c4cccc1c4c32 CHEMBL3922789 IC50 0.3 nM
CN(C)CCn1c2c3c4c(cc(F)cc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL3929889 IC50 0.3 nM
CN(C)CCn1c2c3c4c(cccc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL3975917 IC50 0.3 nM
C[C@@H]1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(-c3nccs3)n21 CHEMBL5420649 IC50 0.3 nM
O=C(COc1ccc2c(c1)CCCN2C(=O)CCl)NCCCCCCCCCC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1 CHEMBL5182405 IC50 0.32 nM
CC(C)(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5419831 IC50 0.33 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(C2CCCCC2)C(=O)C1 CHEMBL5416806 IC50 0.33 nM
CC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5432851 IC50 0.38 nM
C[C@]12CCCN1CC1=NNC(=O)c3cccc4[nH]c2c1c34 CHEMBL4107982 IC50 0.4 nM
CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 CHEMBL1173055 IC50 0.4 nM
CCC(C)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5432860 IC50 0.44 nM
CCCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5394020 IC50 0.49 nM
O=C1NN=C2CN(C(=O)OCc3ccccc3)Cc3[nH]c4cccc1c4c32 CHEMBL3955609 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC2=C(C1)Nc1cccc3c(=O)[nH]nc2c13 CHEMBL3901232 IC50 0.5 nM
CC1(C)CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3972156 IC50 0.6 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(c2ccccc2)C(=O)C1 CHEMBL5423072 IC50 0.62 nM
CC(C)C(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1C CHEMBL5080271 IC50 0.64 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)NCCc3nc4c(C(N)=O)cccc4[nH]3)cc1)C2=O CHEMBL4529965 pIC50 0.6457 nM
CC1(C)CCc2[nH]c3cc(F)cc4c3c2C1=NNC4=O CHEMBL3914932 IC50 0.7 nM
CC1(C)CC2=NNC(=O)c3c(F)ccc4[nH]c(c2c34)C1 CHEMBL3901034 IC50 0.7 nM
CC1(C)CCC2=C(C1)c1n[nH]c(=O)c3cccc(c13)N2 CHEMBL3955370 IC50 0.7 nM
O=C1NN=C2CCCCc3[nH]c4cc(F)cc1c4c32 CHEMBL3962648 IC50 0.7 nM
CC(C)C1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3925115 IC50 0.7 nM
C=CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5395127 IC50 0.71 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCCCC1 CHEMBL3939501 IC50 0.73 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCC1 CHEMBL3952089 IC50 0.77 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1Cc1ccccc1 CHEMBL5418896 IC50 0.77 nM
CCC(CC)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5406119 IC50 0.79 nM
O=C1NN=C2CCCc3[nH]c4cc(F)cc1c4c32 CHEMBL3929705 IC50 0.8 nM
CC(C)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3907535 IC50 0.8 nM
COCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5419161 IC50 0.83 nM
CCC(CC)N1CCN(C(=O)c2cc(Cn3c(=O)[n-]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5403305 IC50 0.87 nM
Cc1c(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4858564 IC50 0.89 nM
CC1(C)CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1=O CHEMBL3961684 IC50 0.9 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCCC1 CHEMBL3893294 IC50 0.9 nM
Cc1c(CN2CCN(C(=O)c3cc4cccc(C(N)=O)c4o3)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4865059 IC50 0.92 nM
CC(C)CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5406001 IC50 0.92 nM
CCCCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5437947 IC50 0.94 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1cccnc1 CHEMBL595018 IC50 1.0 nM
O=C1NCC2c3c(cccc31)CCN2C(=O)CCc1cnccn1 CHEMBL609002 IC50 1.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCNCC4)cc3)nc12 CHEMBL1090136 Ki 1.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4ccncc4)cc3)nc12 CHEMBL577549 Ki 1.0 nM
N#Cc1cccnc1N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4ccccc34)c2)CC1 CHEMBL3740104 IC50 1.0 nM
CC(C)(N)C(=O)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3970252 IC50 1.0 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(CCC2CC2)C1 CHEMBL4067999 IC50 1.0 nM
O=c1[nH]nc2c3c(cccc13)N=C(CN1Cc3ccccc3C1)N2 CHEMBL3644587 IC50 1.0 nM
O=C1NN=C2CCCCc3[nH]c4cccc1c4c32 CHEMBL3969742 IC50 1.1 nM
CC(C)C1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3907218 IC50 1.1 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5s4)CC3)oc12 CHEMBL4871210 IC50 1.19 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCNC1 CHEMBL3978225 IC50 1.2 nM
COc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5176874 IC50 1.2 nM
CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5413070 IC50 1.22 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC(F)(F)F CHEMBL5072662 IC50 1.24 nM
CC(C)(C)[Si](C)(C)OCCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL4569417 IC50 1.29 nM
CC(C)(C)C(=O)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3978989 IC50 1.3 nM
C[C@]1(c2nc3c(C(N)=O)cccc3[nH]2)CCCN1 CHEMBL506871 IC50 1.3 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4755076 IC50 1.3 nM
CC1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3910080 IC50 1.3 nM
CCC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5404171 IC50 1.32 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5o4)CC3)oc12 CHEMBL4868231 IC50 1.34 nM
CC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1C CHEMBL5073404 IC50 1.49 nM
NC(=O)c1cccc2[nH]c(-c3ccc([C@@H]4CCCN4)cc3F)nc12 CHEMBL1090467 Ki 1.5 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCN(Cc2ccccc2)C1 CHEMBL3939375 IC50 1.5 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5c(N)cccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4747106 IC50 1.5 nM
COc1cc(-c2nn[nH]n2)ccc1/C=C1\Oc2c(C(N)=O)cccc2C1=O CHEMBL4518901 pIC50 1.585 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCn4c(nnc4C(F)(F)F)C3)cc1)C2=O CHEMBL4519178 pIC50 1.585 nM
O=C1NN=C2CC(c3ccccc3)Cc3[nH]c4cccc1c4c32 CHEMBL3892363 IC50 1.6 nM
CC1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3915929 IC50 1.7 nM
CC(C)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5428217 IC50 1.72 nM
O=C1NN=C2CC(c3ccccc3)Cc3[nH]c4cc(F)cc1c4c32 CHEMBL3900548 IC50 1.8 nM
CC(C)C(C)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5434732 IC50 1.86 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC(F)(F)F CHEMBL5421933 IC50 1.87 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1 CHEMBL5428859 IC50 1.88 nM
O=C1NN=C2CCCc3[nH]c4cccc1c4c32 CHEMBL3891329 IC50 1.9 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCn4c(nnc4C4CC4)C3)cc1)C2=O CHEMBL4575227 IC50 1.9 nM
CNCc1ccc(-c2cc3cc(F)cc(C(N)=O)c3o2)cc1 CHEMBL4584534 IC50 1.9 nM
CNCc1ccc(-c2cc3cc(F)cc(C(N)=O)c3o2)cc1 CHEMBL5286956 IC50 1.9 nM
C[C@@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCCN1 CHEMBL497608 Ki 2.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCNC1 CHEMBL526668 Ki 2.0 nM
CC1(c2nc3c(C(N)=O)cccc3[nH]2)CCNCC1 CHEMBL495942 Ki 2.0 nM
CC(C)N1CCC(c2nc3c(C(N)=O)cccc3[nH]2)CC1 CHEMBL452801 Ki 2.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4ccccn4)cc3)nc12 CHEMBL576423 Ki 2.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCN4)cc3)nc12 CHEMBL1093844 Ki 2.0 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(-c3nn[nH]n3)cc1)C2=O CHEMBL4454914 pIC50 2.042 nM
NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 CHEMBL1094636 IC50 2.1 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CCC1CC1 CHEMBL5437813 IC50 2.15 nM
CC(C)C(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5093731 IC50 2.34 nM
NC(=O)c1ccccc1OCc1cccc(NC(=O)c2ccc(Br)cc2)c1 CHEMBL5416841 IC50 2.34 nM
CC(C)=CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5400153 IC50 2.35 nM
O=C(/C=C/c1ccc(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1)NO CHEMBL4078014 IC50 2.53 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)c(F)c1 CHEMBL4753410 IC50 2.6 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5419639 IC50 2.63 nM
COC(=O)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5421189 IC50 2.67 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(CCC(F)(F)F)C1 CHEMBL4083291 IC50 2.9 nM
C[C@@H]1CN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CCN1 CHEMBL5203682 IC50 2.91 nM
C#CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5399361 IC50 2.92 nM
NC(=O)c1cccc2[nH]c([C@@H]3CCC(=O)N3)nc12 CHEMBL460267 Ki 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCN4)cc3F)nc12 CHEMBL1093309 Ki 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCCN4)cc3)nc12 CHEMBL1093900 Ki 3.0 nM
NC(=O)c1cccc2[nH]c(-c3ccc(C4CCCNC4)cc3)nc12 CHEMBL1092691 Ki 3.0 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCn4c(nnc4C(F)F)C3)cc1)C2=O CHEMBL4446105 IC50 3.0 nM
Cn1cnc(-c2nnc3n2CCN(C(=O)c2ccc(/C=C4\Oc5c(C(N)=O)cccc5C4=O)cc2)C3)c1 CHEMBL4586938 IC50 3.3 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CC(=O)N2CCCCC2C1 CHEMBL5414478 IC50 3.41 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCn4c(CC5CC5)nnc4C3)cc1)C2=O CHEMBL4450747 pIC50 3.467 nM
CCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5427496 IC50 3.48 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(CC2CC2)C1 CHEMBL4061458 IC50 3.6 nM
CCOC(=O)c1nnc2n1CCN(C(=O)c1ccc(/C=C3\Oc4c(C(N)=O)cccc4C3=O)cc1)C2 CHEMBL4539194 pIC50 3.631 nM
Nc1cc(C(F)(F)F)c(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL4470724 pIC50 3.631 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCn4c(nnc4C4CCCC4)C3)cc1)C2=O CHEMBL4469675 pIC50 3.802 nM
N#Cc1ccc(N2CCN(CCCc3cc4c(N)cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL4748390 IC50 3.9 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)cc1)C2=O CHEMBL4474593 pIC50 3.981 nM
C[C@]1(c2nc3c(C(N)=O)cc(F)cc3[nH]2)CCCN1 CHEMBL495743 Ki 4.0 nM
NC(=O)c1cccc2nc(-c3ccc([C@@H]4CCCCN4)cc3F)[nH]c12 CHEMBL1089125 Ki 4.0 nM
Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2 CHEMBL1086580 IC50 4.0 nM
CCc1cc2ncc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5095220 IC50 4.0 nM
Cn1ncnc1[C@@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@H]1c1ccc(F)cc1 CHEMBL3764816 IC50 4.1 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(c2ccccc2)C1 CHEMBL4100719 IC50 4.1 nM
NC1CCN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CC1 CHEMBL5182785 IC50 4.21 nM
C[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC(F)(F)F CHEMBL5073596 IC50 4.25 nM
NC(=O)c1ccccc1OCc1cccc(NC(=O)c2ccc(Cl)cc2)c1 CHEMBL5427365 IC50 4.36 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(C(=O)C2CC2)C1 CHEMBL4072243 IC50 4.5 nM
CC(C)c1nnc2n1CCN(C(=O)c1ccc(/C=C3\Oc4c(C(N)=O)cccc4C3=O)cc1)C2 CHEMBL4435102 pIC50 4.571 nM
NC(=O)c1ccc(N2CCN(CCCc3cc4c(N)cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL4800042 IC50 4.6 nM
CC[C@@H]1C(=O)N(C)c2cnc(N(C)c3ccc(-c4nc5c(C(N)=O)cccc5[nH]4)cc3OC)nc2N1C1CCCC1 CHEMBL5084388 IC50 4.7 nM
Cc1ccc2[nH]c(CCNC(=O)c3ccc(/C=C4\Oc5c(C(N)=O)cccc5C4=O)cc3)nc2c1 CHEMBL4446923 pIC50 4.786 nM
C[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5080640 IC50 4.93 nM
CCCN1CCC(c2nc3cccc(C(N)=O)c3[nH]2)CC1 CHEMBL452800 Ki 5.0 nM
O=C(/C=C/c1ccc(CCNC(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)cc1)NO CHEMBL4096060 IC50 5.02 nM
CCc1cc2ncc(CN3CCN(c4cnc5cn[nH]c5c4)CC3)cc2[nH]c1=O CHEMBL5190645 IC50 5.2 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(Cc2ccccc2)C1 CHEMBL4093008 IC50 5.4 nM
O=C1NCCn2c(-c3ccc(N4CCNCC4)cc3)nc3cncc1c32 CHEMBL4522170 IC50 5.5 nM
CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5408420 IC50 5.62 nM
O=C1NCCc2c(-c3ccc(CN4CCN(c5ncccn5)CC4)cc3)[nH]c3cc(F)cc1c23 CHEMBL5170407 IC50 5.71 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(Cc2ccncc2)C1 CHEMBL4082728 IC50 5.8 nM
COc1cccc2[nH]c3c4c(c5c(c3c12)C(=O)N(CN1CCN(C)CC1)C5=O)CCC4 CHEMBL4297461 IC50 6.0 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(c4nc(-c5cnc(NC(=O)CN6CCOCC6)cc5C(F)(F)F)nc(N5CCOCC5)n4)CC3)oc12 CHEMBL4761383 IC50 6.2 nM
O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CCCO CHEMBL5414994 IC50 6.31 nM
CC(=O)N1CCN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CC1 CHEMBL5183006 IC50 6.4 nM
O=C1NCCc2c(-c3ccc(CN4CCN(CCO)CC4)cc3)[nH]c3cc(F)cc1c23 CHEMBL5174694 IC50 6.68 nM
CN(C)CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5393999 IC50 6.75 nM
CCC(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1CC CHEMBL5088601 IC50 6.91 nM
CCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1C CHEMBL5087953 IC50 6.98 nM
CNCc1ccc(-c2nc3cncc4c3n2CCNC4=O)cc1 CHEMBL4458889 IC50 7.2 nM
N#Cc1ccc(N2CCN(CCCc3cc4c(N)cccc4c(=O)[nH]3)CC2)cc1 CHEMBL4787850 IC50 7.2 nM
CC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5081000 IC50 7.31 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(=O)C(F)(F)F CHEMBL5079913 IC50 7.31 nM
C/C=C/CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1C CHEMBL5080395 IC50 7.4 nM
C[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5083291 IC50 7.41 nM
CC(C)=CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1C CHEMBL5089572 IC50 7.56 nM
CC(C)CN1CCC(c2nc3cncc4c3n2CCNC4=O)CC1 CHEMBL4435879 IC50 7.7 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(=O)C1CC1 CHEMBL5075095 IC50 7.96 nM
NC(=O)c1cccc2[nH]c(-c3ccc(-c4cccnc4)cc3)nc12 CHEMBL571285 Ki 8.0 nM
N#Cc1ccc(-c2cnc3cccc(C(N)=O)c3n2)cc1 CHEMBL481603 IC50 8.0 nM
CC(C)(C)OC(=O)NC1CCN(Cc2ccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)cc2)CC1 CHEMBL5193574 IC50 8.04 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4776820 IC50 8.1 nM
CC(C)(C)OC(=O)N1CC[C@H](C(=O)Nc2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)cnc2F)C1 CHEMBL4092324 IC50 8.6 nM
CCc1cc2ncc(CN3CC4(C3)CN(c3ccc(C(=O)NC)nc3)C4)cc2[nH]c1=O CHEMBL5193674 IC50 9.0 nM
CC(C)(C)OC(=O)N1CC[C@H](C(=O)Nc2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2Cl)C1 CHEMBL4082114 IC50 9.1 nM
O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CC(=O)N2CCCC2C1 CHEMBL5434897 IC50 9.2 nM
Nc1cc(F)cc2c(=O)[nH]c(CCCN3CCN(c4ccc(F)cc4)CC3)cc12 CHEMBL4781887 IC50 9.5 nM
CCNCc1ccc(-c2nc3cncc4c3n2CCNC4=O)cc1 CHEMBL4460350 IC50 9.9 nM
CN1CCCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)C1 CHEMBL1090483 Ki 10.0 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)NCCc3nc4ccccc4[nH]3)cc1)C2=O CHEMBL4515830 IC50 10.0 nM
CCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5088800 IC50 10.17 nM
CC[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(=O)C1CC1 CHEMBL5094748 IC50 10.34 nM
CNC(=O)c1ccc(N2CCN(CCCc3cc4c(N)cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL4786854 IC50 10.8 nM
NC(=O)c1cccc2[nH]c(C3CNC3)nc12 CHEMBL527654 Ki 11.0 nM
CN1CCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)C1 CHEMBL1090582 Ki 11.0 nM
C[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC(F)(F)F CHEMBL5094072 IC50 11.19 nM
CCN(CC)Cc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 CHEMBL5208255 IC50 11.21 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(CC(F)(F)F)C1 CHEMBL4099732 IC50 11.5 nM
CC[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(=O)C(F)(F)F CHEMBL5077121 IC50 11.51 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCN(C2CCC(F)(F)CC2)C1 CHEMBL4095389 IC50 11.9 nM
CN1CCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)CC1 CHEMBL1093012 Ki 12.0 nM
CC(C)(C)OC(=O)N1CC[C@H](C(=O)Nc2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)cnc2Cl)C1 CHEMBL4068890 IC50 12.2 nM
CC(C)=CCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5088510 IC50 12.79 nM
CCC(=O)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1CC CHEMBL5084022 IC50 13.68 nM
CC[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(C)=O CHEMBL5086078 IC50 13.97 nM
CC1Cc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc2CN1 CHEMBL4294222 IC50 14.0 nM
CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1 CHEMBL372303 IC50 14.7 nM
C/C=C/CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1C CHEMBL5087572 IC50 14.95 nM
CC[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC CHEMBL5083752 IC50 15.46 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5083950 IC50 15.63 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncccc5c(=O)[nH]4)CC3)CC2)nc1 CHEMBL4746309 IC50 16.6 nM
O=C1NCCc2c1ccc1[nH]cc(CCNC(=O)N3CCCNCC3)c21 CHEMBL560790 IC50 17.0 nM
C[C@@H](COCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5095043 IC50 17.0 nM
CN1CCCCC1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1090482 Ki 18.0 nM
CN1CCCC1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1092737 Ki 18.0 nM
CCc1cc2ncc(CN3CC4CN(c5ccc(C(=O)NC)nc5)CC4C3)cc2[nH]c1=O CHEMBL5180001 IC50 18.0 nM
NC(=O)c1cc(F)cc2[nH]c(C(=O)N3CCC(N)C3)nc12 CHEMBL4076271 IC50 19.0 nM
CCc1cc2ncc(CN3CCn4c(cnc4C(=O)NC)C3)cc2[nH]c1=O CHEMBL5198072 IC50 20.0 nM
CC1(C)CC2=NNC(=O)c3cccc4c3c2c(n4CC2CO2)C1 CHEMBL3940569 IC50 21.0 nM
CCc1cc2ncc(CN3CCN(c4ccc5cc[nH]c5n4)CC3)cc2[nH]c1=O CHEMBL5205419 IC50 21.0 nM
CC(C)N1CCCC(c2ccc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2)C1 CHEMBL1092223 Ki 23.0 nM
CCc1cc2ncc(CN3CCN(c4ccc5[nH]ncc5n4)CC3)cc2[nH]c1=O CHEMBL5185522 IC50 23.0 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC CHEMBL5089136 IC50 23.11 nM
NC(=O)c1cccc2[nH]c(C3CCN(S(=O)(=O)c4ccccc4)CC3)nc12 CHEMBL518484 Ki 24.0 nM
NC(=O)c1cc(F)cc2[nH]c(C(=O)N3CCC(N)CC3)nc12 CHEMBL4080699 IC50 24.0 nM
CC[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1 CHEMBL5087831 IC50 24.35 nM
C[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1 CHEMBL5081921 IC50 25.58 nM
CC(C)N1CCCCC1c1ccc(-c2nc3c(C(N)=O)cccc3[nH]2)cc1 CHEMBL1089474 Ki 26.0 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(C)=O CHEMBL5071826 IC50 26.39 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncc(F)cc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4789581 IC50 26.9 nM
CC(C)N1CCC(n2c(=O)c3c(C(N)=O)cccc3n2C)CC1 CHEMBL3663645 Kd 30.0 nM
Cc1c(-c2nc3c(C(N)=O)cc(F)cc3[nH]2)sc2c1CCNC2 CHEMBL4291682 IC50 30.0 nM
O=C(NO)c1ccc(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL4097093 IC50 31.52 nM
O=C1NCCc2c1ccc1[nH]cc(CCNC(=O)N3CCNCC3)c21 CHEMBL558845 IC50 32.0 nM
CN1CCC(N2Cc3cccc(C(N)=O)c3C2=O)CC1 CHEMBL3605990 Kd 33.0 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1 CHEMBL5092897 IC50 33.29 nM
NC(=O)c1cc(F)cc2[nH]c(C(=O)N3CCC(NC4CCCCC4)CC3)nc12 CHEMBL4098745 IC50 34.0 nM
Oc1ccc2c(c1)sc1nncn12 CHEMBL5406267 pIC50 36.31 nM
CC[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1C(C)C CHEMBL5074757 IC50 36.4 nM
O=c1[nH]c(SCCN2CCN(CCSc3nc4ccccc4c(=O)[nH]3)CC2)nc2ccccc12 CHEMBL4638701 IC50 37.8 nM
NC(=O)c1cc(F)cc2[nH]c(C(=O)N3CCC(NC4CCCCC4)C3)nc12 CHEMBL4081378 IC50 38.0 nM
CCc1cc2ncc(CN3CCN(c4cc5c(cn4)NC(=O)CC5)CC3)cc2[nH]c1=O CHEMBL5201927 IC50 38.0 nM
CN1CCC(n2[nH]c3cccc(C(N)=O)c3c2=O)CC1 CHEMBL3663643 Kd 40.0 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1Cl)[C@H]1CCNC1 CHEMBL4101084 IC50 40.0 nM
CCc1cc2ncc(CN3CCC(Nc4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O CHEMBL5202261 IC50 40.0 nM
CCc1cc2ncc(CN3CCc4cc(/C=C/C(=O)NC)ccc4C3)cc2[nH]c1=O CHEMBL5206717 IC50 41.53 nM
Cn1c(-c2cc3c(s2)CNCC3)nc2c(C(N)=O)cc(F)cc21 CHEMBL4281045 IC50 42.0 nM
CC[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CC1 CHEMBL5087801 IC50 42.82 nM
CCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@@H]1CC CHEMBL5090532 IC50 47.54 nM
NC(=O)c1cccc2[nH]c(C(=O)N3CCC(N)C3)nc12 CHEMBL4091897 IC50 48.0 nM
O=C1NCCn2c(-c3cc4c(s3)CCNC4)nc3cc(F)cc1c32 CHEMBL4289667 IC50 49.0 nM
O=C(Cc1ccc(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1)NO CHEMBL4075511 IC50 49.12 nM
Cn1c2cccc(C(N)=O)c2c(=O)n1C1CCN(C2CCCC2)CC1 CHEMBL3663642 Kd 50.0 nM
CCOC(=O)Nc1nc2ccc(-c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)cc2[nH]1 CHEMBL5184668 IC50 50.0 nM
CCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)C[C@H]1CC CHEMBL5088094 IC50 50.65 nM
NC(=O)c1cccc2[nH]c(-c3cc4c(s3)CNCC4)nc12 CHEMBL4289496 IC50 53.0 nM
C[C@@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1 CHEMBL5093696 IC50 55.38 nM
N#Cc1ccc(N2CCN([C@@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)c(F)c1 CHEMBL4776507 IC50 58.0 nM
CCc1cc2ncc(CN3CCN(c4ccc5nc(C(F)(F)F)[nH]c5n4)CC3)cc2[nH]c1=O CHEMBL5185548 IC50 60.0 nM
CC[C@H]1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC(F)(F)F CHEMBL5079003 IC50 60.6 nM
NC1CCN(Cc2cccc(-c3[nH]c4cc(F)cc5c4c3CCNC5=O)c2)CC1 CHEMBL5197357 IC50 61.9 nM
CNCc1ccc(-c2nc3c(C(N)=O)cc(F)cc3[nH]2)s1 CHEMBL4293056 IC50 64.0 nM
NC(=O)c1cc(Cl)c2cc(-c3cc4c(s3)CNCC4)cnn12 CHEMBL4744702 IC50 66.81 nM
O=C(NC1CCN(CC2CC2)C1)c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F CHEMBL4533690 IC50 67.8 nM
CC(C)(C)OC(=O)N1CC[C@H](C(=O)Nc2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2Br)C1 CHEMBL4087554 IC50 68.0 nM
CCc1cc2ncc(CN3CCC(Nc4ccc(C(=O)NC)nc4)C3)cc2[nH]c1=O CHEMBL5178741 IC50 68.0 nM
Cn1c2cc(F)cc(C(N)=O)c2c(=O)n1C1CCNCC1 CHEMBL3663649 Kd 70.0 nM
CC(C)(C)[C@@H]1NCCC2C=C(c3nc4c(C(=O)O)cc(F)cc4[nH]3)SC21 CHEMBL4286249 IC50 70.0 nM
NC(=O)c1cccc2[nH]c(C(=O)N3CCC(N)CC3)nc12 CHEMBL4079788 IC50 73.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3cc4c(s3)CCNC4)nc12 CHEMBL4280657 IC50 73.0 nM
CC(C)(C)CN1CCC(NC(=O)c2nc3c(C(N)=O)cc(F)cc3[nH]2)CC1 CHEMBL4076845 IC50 74.0 nM
CC(C)N1CCC(N2Cc3cccc(C(N)=O)c3C2=O)CC1 CHEMBL3605992 Kd 75.0 nM
CCCNC1CCN(C(=O)c2nc3c(C(N)=O)cccc3[nH]2)C1 CHEMBL4070559 IC50 75.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1-c1nc2c(C(N)=O)cccc2[nH]1 CHEMBL5437375 IC50 78.4 nM
O=C(Nc1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)cnc1F)[C@H]1CCNC1 CHEMBL4083109 IC50 80.0 nM
CN1CCc2sc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)cc2C1 CHEMBL4291982 IC50 83.0 nM
CC(C)(C)C1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc21 CHEMBL4279065 IC50 86.0 nM
CC1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc21 CHEMBL4282620 IC50 87.0 nM
CCc1cc2ncc(CN3CCN(c4ccc5oc(=O)[nH]c5c4)CC3)cc2[nH]c1=O CHEMBL5196723 IC50 87.0 nM
N#Cc1ccc(C2CCN(CCCc3nc4c(Cl)cccc4c(=O)[nH]3)CC2)cc1 CHEMBL5398361 IC50 87.0 nM
NC(=O)c1cccc2[nH]c(C(=O)N3CCC(NC4CCCCC4)C3)nc12 CHEMBL4077812 IC50 91.0 nM
O=C1NCCn2c(-c3cc4c(s3)CNCC4)nc3cc(F)cc1c32 CHEMBL4281789 IC50 99.0 nM
NC(=O)c1cccc2[nH]c(C(=O)NC3CCN(CC(F)(F)F)CC3)nc12 CHEMBL4100391 IC50 100.0 nM
CN1CCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc2C1 CHEMBL4288557 IC50 109.0 nM
NC(=O)c1cccc2[nH]c(-c3cc4c(s3)CCNC4)nc12 CHEMBL4287147 IC50 113.0 nM
CC(C)CC1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4n3C)sc21 CHEMBL4277920 IC50 117.0 nM
O=C(c1cc(CC2=NNB(O)c3ccccc32)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL5440473 IC50 120.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3cc4c(s3)CNCC4)nc12 CHEMBL4290904 IC50 124.0 nM
COCCCN1Cc2cccc(C(N)=O)c2C1=O CHEMBL3605967 Kd 125.0 nM
O=C(O)CCc1nc(O)c2ccccc2n1 CHEMBL1892587 IC50 125.0 nM
NC(=O)c1cccc2[nH]c(C(=O)NC3CCN(CC4CC4)CC3)nc12 CHEMBL4081066 IC50 130.0 nM
CN1CCc2sc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2C1 CHEMBL4279230 IC50 131.0 nM
CCc1cc2ncc(CN3CC[C@@H](Nc4ccc(C(=O)NC)nc4)C3)cc2[nH]c1=O CHEMBL5179882 IC50 133.0 nM
CCc1cc2ncc(CN3CC[C@H](Nc4ccc(C(=O)NC)nc4)C3)cc2[nH]c1=O CHEMBL5195834 IC50 137.0 nM
Cn1c2cccc(C(N)=O)c2c(=O)n1C1CCNCC1 CHEMBL3663644 Kd 140.0 nM
CCN1CCc2sc(-c3nc4c(C(N)=O)cccc4[nH]3)cc2C1 CHEMBL4278820 IC50 140.0 nM
O=C1SCCc2nc(-c3ccc(C(F)(F)F)cc3)[nH]c(=O)c21 CHEMBL4059827 IC50 141.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3cc4c(o3)CNCC4)nc12 CHEMBL4288572 IC50 144.0 nM
Cc1cccc2c(=O)[nH]c(CCC(=O)O)nc12 CHEMBL4080163 pIC50 144.54 nM
CCC1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc21 CHEMBL4277995 IC50 145.0 nM
NC(=O)c1cc(F)cc2[nH]c(C3=NC4CCNCC4S3)nc12 CHEMBL4285227 IC50 149.0 nM
CCc1cc2ncc(CN3CCN(c4cc5cccc(C(=O)NC)c5cn4)CC3)cc2[nH]c1=O CHEMBL5187899 IC50 151.0 nM
CCc1cc2ncc(CN3CCN(c4ccc(OC(F)F)nc4)CC3)cc2[nH]c1=O CHEMBL5191912 IC50 154.0 nM
N#Cc1ccc(N2CCN([C@@H]3C=C(c4cc5c(N)cccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4741921 IC50 167.0 nM
Cc1cccc2c(=O)[nH]c(CCCN3CCC(c4ccc(F)cc4)CC3)nc12 CHEMBL5401937 IC50 167.0 nM
NC(=O)c1cccc2c1C(=O)N(CCc1ccccc1)C2 CHEMBL3605972 Kd 178.0 nM
CCc1cc2ncc(CN3CC(Nc4ccc(C(=O)NC)nc4)C3)cc2[nH]c1=O CHEMBL5173989 IC50 192.0 nM
CC(C)C1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc21 CHEMBL4282534 IC50 196.0 nM
N#Cc1ccc(N2CCN([C@@H]3C=C(c4cc5c(N)cc(F)cc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4777158 IC50 200.0 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn12 CHEMBL5199558 IC50 200.0 nM
NC(=O)c1cc(Cl)c2cc(-c3cc4c(s3)CCNC4)cnn12 CHEMBL4758651 IC50 209.38 nM
CC(C)CC1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc21 CHEMBL4286332 IC50 219.0 nM
O=C(Nc1cncc(Cn2c(=O)[nH]c(=O)c3ccccc32)c1)[C@H]1CCNC1 CHEMBL4084234 IC50 220.0 nM
NC(=O)c1cc(F)cc2[nH]c(-c3cc4c(s3)C(C3CC3)NCC4)nc12 CHEMBL4289750 IC50 239.0 nM
NCCOc1c(-c2ccc(N3CCOCC3)c(Br)c2)[nH]c(=O)c2cc(F)ccc12 CHEMBL3959475 Kd 240.0 nM
Oc1ccc(O)c2c1sc1nncn12 CHEMBL5421878 IC50 240.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)CCCC4)CC2)cc1 CHEMBL3933931 IC50 243.0 nM
CN1CCc2cc(-c3nc4c(C(N)=O)cccc4[nH]3)sc2C1 CHEMBL4276836 IC50 247.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(Br)cc3)nc12 CHEMBL3827963 IC50 259.0 nM
CC(C)CN1CCC(N2Cc3cccc(C(N)=O)c3C2=O)CC1 CHEMBL3605993 Kd 264.0 nM
Cc1cc(C(N)=O)c2nc(-c3cc4c(s3)CNCC4)[nH]c2c1 CHEMBL4287485 IC50 281.0 nM
NC(=O)c1cccc2c1C(=O)N(CCCc1ccccc1)C2 CHEMBL3605973 Kd 286.0 nM
NC(=O)c1cc(F)cc2[nH]n(C3CCNCC3)c(=O)c12 CHEMBL3663648 Kd 300.0 nM
O=c1[nH]c(CCCN2CCN(c3ccccc3)CC2)nc2cccc(Cl)c12 CHEMBL5432033 IC50 300.0 nM
CCCC1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc21 CHEMBL4285923 IC50 324.0 nM
Cn1c(-c2cc3c(s2)C(C(C)(C)C)NCC3)nc2c(C(N)=O)cc(F)cc21 CHEMBL4291992 IC50 328.0 nM
CCN1CCC(N2Cc3cccc(C(N)=O)c3C2=O)CC1 CHEMBL3605991 Kd 340.0 nM
O=c1[nH]c(SCCN2CCN(CCCOc3ccc(-c4ccccc4)cc3)CC2)nc2ccccc12 CHEMBL4642139 IC50 340.0 nM
CCc1cc2ncc(CN3C[C@@H]4C[C@H]3CN4c3ccc(C(=O)NC)nc3)cc2[nH]c1=O CHEMBL5179279 IC50 340.0 nM
O=C1CC2(CCN(C(=O)CN3CCN(CCSc4nc5ccccc5c(=O)[nH]4)CC3)CC2)Oc2ccccc21 CHEMBL4632484 IC50 347.0 nM
CCCCC1NCCc2cc(-c3nc4c(C(N)=O)cc(F)cc4[nH]3)sc21 CHEMBL4293136 IC50 348.0 nM
CC(C)(C)[C@H]1NCCC2C=C(c3nc4c(C(=O)O)cc(F)cc4[nH]3)SC21 CHEMBL4278332 IC50 356.0 nM
CCn1c(-c2cc3c(s2)CNCC3)nc2c(C(N)=O)cc(F)cc21 CHEMBL4281379 IC50 359.0 nM
CN1CCc2sc(-c3ccc4c(Cl)cc(C(N)=O)n4n3)cc2C1 CHEMBL4756907 IC50 363.35 nM
O=c1[nH]c(SCCN2CCN(CCCc3nc(-c4ccccc4)no3)CC2)nc2ccccc12 CHEMBL4648016 IC50 370.0 nM
NC(=O)c1cc(Cl)cc2[nH]c(-c3cc4c(s3)CNCC4)nc12 CHEMBL4280264 IC50 382.0 nM
CN1CCc2cc(-c3ccc4c(Cl)cc(C(N)=O)n4n3)sc2C1 CHEMBL4744208 IC50 382.13 nM
NC(=O)c1cccc2c1C(=O)N(CCN1CCCc3ccccc31)C2 CHEMBL3605982 Kd 420.0 nM
CCCN1Cc2cccc(C(N)=O)c2C1=O CHEMBL1329044 Kd 422.0 nM
NC(=O)c1cccc2c1C(=O)N(C1CCN(CC3CC3)CC1)C2 CHEMBL3605994 Kd 441.0 nM
NC(=O)c1cc(Cl)c2ccc(-c3ccc(CN4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)nn12 CHEMBL4761828 IC50 445.06 nM
CCc1cc2ncc(CN3CCN(c4ccc(C(C)(C)O)nc4)CC3)cc2[nH]c1=O CHEMBL5180063 IC50 450.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CCSC2 CHEMBL2431805 pIC50 478.63 nM
CCc1cc2ncc(CN3CCc4nc(C(=O)NC)ccc4C3)cc2[nH]c1=O CHEMBL5176626 IC50 485.0 nM
Cc1cnc(N2CCN(Cc3ccc4c5c(c(=O)[nH]c4c3)CCCC5)CC2)n1C CHEMBL5177596 IC50 490.0 nM
O=c1[nH]c(CCCN2CC=C(c3ccc(F)cc3)CC2)nc2c(Cl)cccc12 CHEMBL251030 IC50 500.0 nM
Cn1c2cc(F)cc(C(N)=O)c2c(=O)n1C1CCN(C2CCCCC2)CC1 CHEMBL3663650 Kd 500.0 nM
O=c1[nH]c(CCCN2CCC(c3ccc(F)cc3)CC2)nc2c(Cl)cccc12 CHEMBL250490 IC50 500.0 nM
CC(C)CC1NCCc2cc(-c3cnn4c(C(N)=O)cc(Cl)c4c3)sc21 CHEMBL4741696 IC50 501.6 nM
Cn1c2cccc(C(N)=O)c2c(=O)n1C1CCN(C2CCCCC2)CC1 CHEMBL3663640 Kd 540.0 nM
N#Cc1ccc(-c2[nH]c(=O)c3cc(F)ccc3c2OCCN)cc1 CHEMBL3957318 Kd 540.0 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(C(F)(F)F)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5395820 IC50 546.0 nM
O=c1[nH]c(SCCN2CCN(c3ccccn3)CC2)nc2ccccc12 CHEMBL4460557 IC50 549.0 nM
COc1cccc2c(O)nc(-c3ccc(C(F)(F)F)cc3)nc12 CHEMBL123798 IC50 570.0 nM
NC(=O)c1cccc2c1C(=O)N(CCO)C2 CHEMBL3605970 Kd 575.0 nM
NC(=O)c1cccc2c1C(=O)N(C1CCN(Cc3ccoc3)CC1)C2 CHEMBL3606012 Kd 583.0 nM
Cc1cnc(N2CCN(Cc3ccc4c(c3)[nH]c(=O)c3ccccc34)CC2)n1C CHEMBL5191396 IC50 600.0 nM
O=c1cc(-c2ccc(O)cc2)oc2c(CN3CCN(Cc4cccs4)CC3)c(O)cc(O)c12 CHEMBL4868405 Kd 605.4 nM
O=c1[nH]c(CCCN2CCC(c3ccccc3)CC2)nc2ccccc12 CHEMBL249813 IC50 608.0 nM
O=c1[nH]c(CCCN2CCC(c3ccccc3)CC2)nc2c(Cl)cccc12 CHEMBL250489 IC50 610.0 nM
O=c1[nH]c(CCCN2CCC(c3ccccc3)CC2)nc2cccc(Cl)c12 CHEMBL5427976 IC50 630.0 nM
NC(=O)c1cccc2c1C(=O)N(CCCN1CCC(Cc3ccccc3)CC1)C2 CHEMBL3605981 Kd 670.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(F)cc3)nc12 CHEMBL3098938 IC50 683.0 nM
O=C(CN1CCC(C(=O)c2ccc(F)cc2)CC1)NCc1nc2c(c(=O)[nH]1)CCCC2 CHEMBL3966085 IC50 700.0 nM
CN(C)Cc1ccc(-c2ccc3c(Cl)cc(C(N)=O)n3n2)cc1 CHEMBL4754497 IC50 704.62 nM
NC(=O)c1cccc2[nH]n(C3CCNCC3)c(=O)c12 CHEMBL3663636 Kd 780.0 nM
O=C(c1ccco1)N1CCN(Cc2c(O)cc(O)c3c(=O)cc(-c4ccc(O)cc4)oc23)CC1 CHEMBL4853039 IC50 800.0 nM
Cc1cccc2c(=O)[nH]c(CSc3ncccn3)nc12 CHEMBL5187963 IC50 800.0 nM
CC(C)(C)C1NCCc2sc(-c3cnn4c(C(N)=O)cc(Cl)c4c3)cc21 CHEMBL4762579 IC50 811.39 nM
O=C(CN1CCC(C(=O)c2ccc(OCC3CCC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3944854 IC50 885.0 nM
O=C(CN1CCC(C(=O)c2ccc(OCCC3CC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3944401 IC50 920.0 nM
COc1cccc2c(O)nc(-c3ccc([N+](=O)[O-])cc3)nc12 CHEMBL125154 IC50 928.0 nM
COc1ccccc1NC(=O)c1ccc(NC(=O)CCc2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL2314698 IC50 931.0 nM
O=C(OCc1ccccc1)N1CCN(CCSc2nc3ccccc3c(=O)[nH]2)CC1 CHEMBL4641894 IC50 963.0 nM
Cc1cc(N2C[C@@H](C)N[C@@H](C)C2)ncc1-c1ccc(-c2nc3c(ccn3C)c(=O)[nH]2)cc1 CHEMBL4101890 pIC50 977.24 nM
CCc1cc2ncc(CN3CCN(c4ccc(C(=O)NC)c5nccn45)CC3)cc2[nH]c1=O CHEMBL5179448 IC50 982.0 nM
NC(=O)c1cccc2c1C(=O)N(C1CCN(Cc3ccc[nH]3)CC1)C2 CHEMBL3606013 Kd 983.0 nM
NC(=O)c1cc(Cl)c2ccc(-c3ccc(CN4CCN(C5CC5)CC4)cc3)nn12 CHEMBL4760246 IC50 997.49 nM
CC(C)(C)C1NCCc2cc(-c3cnn4c(C(N)=O)cc(Cl)c4c3)sc21 CHEMBL4740356 IC50 999.67 nM
NCCOc1c(-c2cccc(Br)c2)[nH]c(=O)c2cc(F)ccc12 CHEMBL3937804 Kd 1000.0 nM
O=C(COc1cccc2c(=O)[nH]ccc12)c1ccccc1 CHEMBL4089840 IC50 1000.0 nM
CC(C)(O)c1ccc(-c2nc3c(F)cc(F)cc3c(=O)[nH]2)cc1 CHEMBL4437173 IC50 1000.0 nM