Cc1nc(C)c(CNc2nc(OC[C@@H]3C[C@H]3c3ccc4ccccc4n3)nc(Cl)c2C)s1 CHEMBL3665948 Ki 0.0006 nM
CC1(C)CC(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)=CCO1 CHEMBL3686946 IC50 0.001 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4ccccc4n3)nn(C)c2=O)s1 CHEMBL4108029 Ki 0.001 nM
Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4c(n3)CCC4)nn(C)c2=O)n(C)n1 CHEMBL4109133 Ki 0.001 nM
C1=C(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CCOC1 CHEMBL3686945 IC50 0.0011 nM
COc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)n1 CHEMBL3691541 IC50 0.0012 nM
Fc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc(C(F)(F)F)c1 CHEMBL3691542 IC50 0.00122 nM
COc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c(OC)n1 CHEMBL3686914 IC50 0.00135 nM
Cc1ncc(-c2c(C)nn(C)c2C)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL3699653 Ki 0.002 nM
COc1ccc(Cc2nc(C)nn2-c2cc(/C=C/c3ccc4ccccc4n3)nc(C)n2)cc1OC CHEMBL3980754 Ki 0.002 nM
COc1ccc(Cc2nc(C)nn2-c2cc(/C=C/c3ccccn3)nc(C)n2)cc1OC CHEMBL3910671 Ki 0.002 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4c(n3)CCC4)nn(C)c2=O)c(C)n1 CHEMBL4106788 Ki 0.002 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4c(n3)CCC4)nn(C)c2=O)s1 CHEMBL4106557 Ki 0.002 nM
Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4c(n3)CCC4)nn(C)c2=O)s1 CHEMBL4111947 Ki 0.002 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cc(C)nn3C)c(=O)n(C)n2)nc1 CHEMBL4110515 Ki 0.002 nM
Cc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccc1Cl CHEMBL3686927 IC50 0.0023 nM
Oc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl CHEMBL3686929 IC50 0.0023 nM
COc1ncccc1-c1nccnc1C1CN(c2ccc3ccccc3n2)C1 CHEMBL3686909 IC50 0.00234 nM
CS(=O)(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686919 IC50 0.00262 nM
Nc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 CHEMBL3686920 IC50 0.00278 nM
Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 CHEMBL3686910 IC50 0.00279 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C3CC3c3nc4ccccc4n3C)nc(C)n2)cc1OC CHEMBL3914246 Ki 0.003 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cc(C)nn3C)c(=O)n(C)n2)nc1 CHEMBL4112063 Ki 0.003 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(C)nc3C)c(=O)n(C)n2)nc1 CHEMBL4109273 Ki 0.003 nM
Cc1cc(CNc2nc(OC[C@H]3C[C@@H]3c3ccc4ncccc4n3)nc(Cl)c2C)n(C)n1 CHEMBL3665961 Ki 0.0032 nM
Cc1nc2ccc(C(F)(F)F)cc2nc1/C=C/c1nc(N[C@@H]2CCS(=O)(=O)C2)cc(N2CCCC2)n1 CHEMBL2180441 IC50 0.0033 nM
COc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1C CHEMBL3686933 IC50 0.0035 nM
Nc1cncc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686921 IC50 0.00376 nM
COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)cc1OC CHEMBL3937178 Ki 0.004 nM
COc1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)cn(C)c1=O CHEMBL4112612 Ki 0.004 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4ccccc4n3)nn(C)c2=O)c(C)n1 CHEMBL4115137 Ki 0.004 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ncc(C)s3)c(=O)n(C)n2)nc1 CHEMBL4113066 Ki 0.004 nM
COc1ccc([C@H]2C[C@@H]2COc2nn(C)c(=O)c(NCc3nnc(C)s3)c2Br)nc1 CHEMBL4111542 Ki 0.004 nM
COc1ccc([C@H]2C[C@@H]2COc2nn(C)c(=O)c(NCc3nnc(C)s3)c2Cl)nc1 CHEMBL4115140 Ki 0.004 nM
Fc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl CHEMBL3686936 IC50 0.0041 nM
Fc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 CHEMBL3686912 IC50 0.00418 nM
Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3686928 IC50 0.0042 nM
COc1ccc(Cc2nc(C)nn2-c2cc([C@@H]3C[C@H]3c3nc4ccccc4[nH]3)nc(C)n2)cc1OC CHEMBL4110592 Ki 0.005 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C3CC3c3nc4ccccc4[nH]3)nc(C)n2)cc1OC CHEMBL3920660 Ki 0.005 nM
Cc1cccc([C@H]2C[C@@H]2COc2cc(NCc3cc(C)nn3C)c(=O)n(C)n2)n1 CHEMBL4110030 Ki 0.005 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4c(n3)CCC4)nn(C)c2=O)cn1 CHEMBL4112605 Ki 0.005 nM
Cc1cc(F)cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686935 IC50 0.0051 nM
Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1C CHEMBL3686939 IC50 0.0055 nM
Cc1nc(C)c(CNc2nc(OCC3CC3c3cc4ccccn4n3)nc(Cl)c2C)s1 CHEMBL3747517 Ki 0.006 nM
Cc1ncc(-c2ccc(=O)n(C)c2C)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4115655 Ki 0.006 nM
CCOc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3686931 IC50 0.0062 nM
Cc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccc1F CHEMBL3686942 IC50 0.0064 nM
Cc1ncccc1-c1nccnc1C1CN(c2ccc3ccccc3n2)C1 CHEMBL3686911 IC50 0.00648 nM
Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl CHEMBL3686940 IC50 0.0067 nM
c1ccc2nc(N3CC(c4nccnc4-c4cn[nH]c4)C3)ccc2c1 CHEMBL3686947 IC50 0.007 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ncc(C)s3)c(=O)n(C)n2)nc1 CHEMBL4114627 Ki 0.007 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(C)nc3C)c(=O)n(C)n2)nc1 CHEMBL4106713 Ki 0.007 nM
Cc1cc(Cl)cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686941 IC50 0.0072 nM
COc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 CHEMBL3686916 IC50 0.00787 nM
c1cncc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686918 IC50 0.00787 nM
Cc1nc(C)c(CNc2nc(OCCCc3ccc4ccccc4n3)nc(Cl)c2C)s1 CHEMBL3622898 Ki 0.008 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cc(C)no3)c(=O)n(C)n2)nc1 CHEMBL4110581 Ki 0.008 nM
Clc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl CHEMBL3686938 IC50 0.0084 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cn(C)nc3C)c(=O)n(C)n2)nc1 CHEMBL4114544 Ki 0.009 nM
FC(F)(F)c1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccc1Cl CHEMBL3686944 IC50 0.0091 nM
Fc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3686937 IC50 0.0099 nM
Cc1nc(C)c(CNc2nc(OCC3CC3c3ccc4ccccc4n3)nc(Cl)c2C)s1 CHEMBL3746993 Ki 0.01 nM
COc1ccnc(C2CC2COc2nc(Cl)c(C)c(NCc3sc(C)nc3C)n2)c1 CHEMBL3745790 Ki 0.01 nM
Cc1ccnc(C2CC2COc2nc(Cl)c(C)c(NCc3sc(C)nc3C)n2)c1 CHEMBL3746277 Ki 0.01 nM
COc1ccc(Cc2nc(C)nn2-c2cc(/C=C/c3ccc4ncccc4n3)nc(C)n2)cc1OC CHEMBL3960405 Ki 0.01 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cc(C)on3)c(=O)n(C)n2)nc1 CHEMBL4111794 Ki 0.01 nM
CCOc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl CHEMBL3686932 IC50 0.0106 nM
CC(C)Oc1cc(F)cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686934 IC50 0.011 nM
Cc1ncc(-c2cc(=O)[nH]cc2C)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4112465 Ki 0.011 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnc(C)s3)c(=O)n(C)n2)nc1 CHEMBL4108340 Ki 0.011 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nnc(C)s3)n3nccc3n2)nc1 CHEMBL3695715 Ki 0.012 nM
COCCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)cc1=O CHEMBL4110358 Ki 0.012 nM
Cc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cnc1F CHEMBL3686917 IC50 0.0122 nM
Fc1cncc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686915 IC50 0.0123 nM
Cn1ccc([C@H]2C[C@@H]2COc2cc(Br)c(=O)n(C)n2)n1 CHEMBL4111052 Ki 0.013 nM
Cc1ncc(-c2ccc(=O)n(C(C)C)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4113752 Ki 0.014 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C)c3)c(=O)n(C)n2)nc1 CHEMBL4107863 Ki 0.014 nM
FC(F)(F)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 CHEMBL3686913 IC50 0.0142 nM
COc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc(C(F)(F)F)c1 CHEMBL3686930 IC50 0.0149 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nnc(C)s3)c(=O)n(C)n2)nc1 CHEMBL4110637 Ki 0.015 nM
Cc1cncc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686925 IC50 0.01625 nM
CCCOc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl CHEMBL3639857 IC50 0.0171 nM
Cc1nc(C)c(CNc2nc(OC[C@H]3C[C@@H]3c3ccccn3)nc(Cl)c2C)s1 CHEMBL3665945 Ki 0.019 nM
Cc1c(Cl)nc(OC[C@@H]2C[C@H]2c2ccc3ncccc3n2)nc1NCc1cnn(C)c1 CHEMBL3665947 Ki 0.019 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)c(C)n1 CHEMBL4107675 Ki 0.019 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(C)cn3)c(=O)n(C)n2)nc1 CHEMBL4108308 Ki 0.019 nM
O=c1ccn(-c2cccc(OC(F)(F)F)c2)nc1-c1ccnn1-c1ccccc1 CHEMBL2180789 IC50 0.019 nM
Cc1nc(C)c(CNc2nc(OCCCc3nc4ccccc4[nH]3)nc(Cl)c2C)s1 CHEMBL3622899 Ki 0.02 nM
Cc1nc(C)c(CNc2nc(OCC3CC3c3ccc4ncccc4n3)nc(Cl)c2C)s1 CHEMBL3746917 Ki 0.02 nM
Cc1nc(C)c(CNc2nc(OCC3CC3c3cn(C)cn3)nc(Cl)c2C)s1 CHEMBL3747450 Ki 0.02 nM
Cc1nc(NCc2nnc(C)s2)cc(OC[C@H]2C[C@@H]2c2ccc3ncccc3n2)n1 CHEMBL3659063 Ki 0.02 nM
Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)n(C)n1 CHEMBL4110725 Ki 0.02 nM
O=C1CC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3694430 IC50 0.021 nM
CCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)cc1=O CHEMBL4107591 Ki 0.021 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nn(C)c2=O)c(C)n1 CHEMBL4112137 Ki 0.021 nM
COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)nn(C)c2=O)cc1 CHEMBL4106926 Ki 0.021 nM
CN(C)c1ncc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 CHEMBL3686923 IC50 0.02279 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C#Cc3ccc4ccccc4n3)nc(C)n2)cc1OC CHEMBL3955247 Ki 0.023 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)c(C)n1 CHEMBL4115367 Ki 0.023 nM
CC(=O)N1CCC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690336 IC50 0.024 nM
Cc1ccc2c(=O)n(-c3ccc4cnn(C)c4c3)c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc2c1 CHEMBL3644274 Ki 0.024 nM
CCn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)ccc1=O CHEMBL4111638 Ki 0.024 nM
COc1cncc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686926 IC50 0.02472 nM
Cc1ccc2c(=O)n(-c3ccc4c(cnn4C)c3)c(CCN3C(=O)c4ccccc4C3=O)nc2c1 CHEMBL3627846 Ki 0.025 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(C)nc3)c(=O)n(C)n2)nc1 CHEMBL4115428 Ki 0.025 nM
Cc1ccncc1-c1nccnc1C1CN(c2ccc3ccccc3n2)C1 CHEMBL3686924 IC50 0.02626 nM
COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ncccc4n3)nc(C)n2)cc1OC CHEMBL3972719 Ki 0.027 nM
COc1ccc(Cc2nc(C)nn2-c2cc([C@H]3C[C@@H]3c3nc4ccccc4[nH]3)nc(C)n2)cc1OC CHEMBL3926763 Ki 0.027 nM
CCc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)n(C)n1 CHEMBL4107437 Ki 0.027 nM
COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)nc1OC CHEMBL3983406 Ki 0.028 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)c(C)n1 CHEMBL4111148 Ki 0.028 nM
O=C1CCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690355 IC50 0.0285 nM
Cc1ccc2c(=O)n(-c3ccc4cnn(CC[18F])c4c3)c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc2c1 CHEMBL5269516 Kd 0.029 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nnc(C)s3)nc(C)n2)nc1 CHEMBL5314924 Ki 0.029 nM
Cc1nc(NCc2cnn(C)c2)cc(OC[C@H]2C[C@@H]2c2ccccn2)n1 CHEMBL3659059 Ki 0.03 nM
Cc1ncc(-c2ccn(C)c(=O)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4112062 Ki 0.03 nM
CCn1nc(OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cc(NCc2nnc(C)s2)c1=O CHEMBL4115264 Ki 0.032 nM
Cc1ncc(-c2cc(=O)n(C)cc2C)c(OC[C@H]2C[C@@H]2c2ccc3c(n2)CCC3)n1 CHEMBL4109486 Ki 0.033 nM
Cc1cccc([C@H]2C[C@@H]2COc2cc(NCc3nnc(C)s3)c(=O)n(C)n2)n1 CHEMBL4113390 Ki 0.033 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)c(C)n1 CHEMBL4107436 Ki 0.034 nM
Cc1ncc(-c2cc(=O)n(C)cc2C)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4114473 Ki 0.035 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741573 IC50 0.037 nM
Cc1cccc([C@H]2C[C@@H]2COc2cc(NCc3ncc(C)s3)c(=O)n(C)n2)n1 CHEMBL4115613 Ki 0.037 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nnc(C)s3)nc(C)n2)nc1 CHEMBL5415653 Ki 0.038 nM
COc1ccc2c(c1OCCF)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3695556 IC50 0.0386 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(C)nn3)c(=O)n(C)n2)nc1 CHEMBL4108702 Ki 0.039 nM
Cc1nc(C)c(CNc2nc(OCCOc3ccc4cccnc4n3)nc(Cl)c2C)s1 CHEMBL3622900 Ki 0.04 nM
Cn1cc(-c2cc3ccncc3nc2OC[C@H]2C[C@@H]2c2ccc3ncccc3n2)cn1 CHEMBL3699652 Ki 0.04 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C)c3)nc(C)n2)nc1 CHEMBL3659078 Ki 0.04 nM
Cc1ncc(-c2cc(=O)n(C)cc2Cl)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4107409 Ki 0.04 nM
Cc1ncc(-c2cc(F)c(=O)n(C)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4110767 Ki 0.041 nM
Cc1ncc(-c2cc(C)n(C)c(=O)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4115082 Ki 0.041 nM
Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)n(C)n1 CHEMBL4112972 Ki 0.044 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4c(c(C(C)C)nn4C)C3)ncnn12 CHEMBL3691455 IC50 0.0444 nM
COCCn1c(C)c(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)ccc1=O CHEMBL4109534 Ki 0.045 nM
CCn1c(C)c(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)ccc1=O CHEMBL4114192 Ki 0.045 nM
COc1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3c(n2)CCC3)cn(C)c1=O CHEMBL4114939 Ki 0.045 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nc(C)c(C)s3)c(=O)n(C)n2)nc1 CHEMBL4111447 Ki 0.045 nM
Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)n(C)n1 CHEMBL4111512 Ki 0.046 nM
Cc1nc(C)c(CNc2nc(OCCCc3cn4ccccc4n3)nc(Cl)c2C)s1 CHEMBL3622901 Ki 0.047 nM
Cc1c(NCc2cnn(C)c2)cc(OC[C@H]2C[C@@H]2c2ccccn2)nc1Cl CHEMBL5424238 Ki 0.047 nM
COc1cc(-c2cccnc2F)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741841 IC50 0.048 nM
Cc1ncc(-c2ccc(=O)n(C(F)F)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4109649 Ki 0.048 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nc(C)c(C)s3)c(=O)n(C)n2)nc1 CHEMBL4109869 Ki 0.048 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3c[nH]nn3)c(=O)n(C)n2)nc1 CHEMBL4111868 Ki 0.048 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cncc(C)c3)c(=O)n(C)n2)nc1 CHEMBL4110322 Ki 0.049 nM
COc1cc(OCc2ccccc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n12 CHEMBL1916128 IC50 0.05 nM
CC(=O)N1CCCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL2180452 IC50 0.05 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nnc(C)s3)nc(N)n2)nc1 CHEMBL3659066 Ki 0.05 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CCCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694433 IC50 0.0505 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)nc1 CHEMBL4106874 Ki 0.051 nM
Cc1ncc(-c2ccc(=O)n(C)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4113565 Ki 0.052 nM
COn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)ccc1=O CHEMBL4109179 Ki 0.053 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cccnc3C)c(=O)n(C)n2)nc1 CHEMBL4111601 Ki 0.053 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N)c4ccccc4n3)c(C)c12 CHEMBL3951578 IC50 0.054 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C)c3)nc(C)n2)nc1 CHEMBL5421428 Ki 0.054 nM
Cc1nc(C)c(CNc2nc(OCCCc3nc4ccccc4s3)nc(Cl)c2C)s1 CHEMBL3622902 Ki 0.055 nM
COc1ccc2c(=O)n(-c3ccc4cc[nH]c4c3)c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc2c1 CHEMBL3644264 Ki 0.055 nM
Cn1c(Nc2ccc(Oc3nccnc3N3CCC(CO)CC3)cc2)nc2ccccc21 CHEMBL2206219 IC50 0.056 nM
COc1ncc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)nc1OC CHEMBL3896176 Ki 0.056 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cn(C)nc3C(F)(F)F)c(=O)n(C)n2)nc1 CHEMBL4110881 Ki 0.056 nM
Cc1nc(C)c(CNc2nc(OC[C@H]3C[C@@H]3c3ccc4ncccc4n3)ncc2C)s1 CHEMBL3665955 Ki 0.058 nM
CCc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)nn(C)c2=O)n(C)n1 CHEMBL4110720 Ki 0.058 nM
O=C1CC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CCN1 CHEMBL3694432 IC50 0.0595 nM
COc1cc(OC(F)F)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n12 CHEMBL1916129 IC50 0.06 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(C(O)c3ccncc3)c2c1 CHEMBL1949936 Ki 0.06 nM
Cc1nc2ccccc2nc1-c1cc2nc(N3CC[C@@H](F)C3)cc(N([11CH3])C3CCOCC3)n2n1 CHEMBL3397907 IC50 0.06 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(O)C(F)(F)F)n1 CHEMBL3915808 Ki 0.06 nM
Nc1nc(-n2ncc3ccncc32)nc(NCc2cncs2)c1Br CHEMBL3979724 IC50 0.06 nM
[11CH3]N(c1cc(N2CC[C@@H](F)C2)nc2cc(-c3cnc4c(n3)CCCC4)nn12)C1CCOCC1 CHEMBL5281567 IC50 0.06 nM
Cc1nc2ccccc2nc1/C=C/c1nc(NC2CCOCC2)cc(N2CCCC2)n1 CHEMBL5266334 IC50 0.06 nM
Cc1nc2ccccc2nc1-c1cc2nc(N3CCC(F)C3)cc(N([11CH3])C3CCOCC3)n2n1 CHEMBL5288856 IC50 0.06 nM
Cc1nc2ccccc2nc1-c1cc2nc(N3CC[C@@H](F)C3)cc(N(C)C3CCOCC3)n2n1 CHEMBL4456440 IC50 0.061 nM
Cc1nc2ccc(F)cc2nc1-c1cc2nc(N3CC[C@@H](F)C3)cc(NCC(C)(C)O)n2n1 CHEMBL4554391 IC50 0.062 nM
O=c1[nH]cc(-c2cccc(OC(F)(F)F)c2)cc1-c1ccnn1-c1ccccc1 CHEMBL5286395 IC50 0.063 nM
Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)s1 CHEMBL4107850 Ki 0.064 nM
CC(=O)N1CCCC[C@@H]1c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690354 IC50 0.0645 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2Cc2cc(F)ccc2F)n1 CHEMBL3908415 Ki 0.065 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cn(C)nn3)c(=O)n(C)n2)nc1 CHEMBL4109682 Ki 0.066 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C3CC3c3ccc4ncccc4n3)nc(C)n2)cc1OC CHEMBL3890836 Ki 0.068 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(C(O)c3ccnc(F)c3)c2c1 CHEMBL1949939 Ki 0.07 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(-c5ccncc5)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3627844 Ki 0.072 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C)c3)c(=O)n(C)n2)nc1 CHEMBL4110243 Ki 0.072 nM
COc1ccncc1-c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3694475 IC50 0.0725 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C#Cc3ccc4ccccc4n3)nc(C)n2)nc1OC CHEMBL3958142 Ki 0.073 nM
COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)cc1 CHEMBL4108758 Ki 0.074 nM
CN1C[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1=O CHEMBL3690305 IC50 0.0748 nM
OCC1CCN(c2cnccc2Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)CC1 CHEMBL2206215 IC50 0.075 nM
O=C1CCCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3694441 IC50 0.077 nM
COc1ccc2c(=O)n(-c3cccc(C)c3)c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc2c1 CHEMBL3644265 Ki 0.077 nM
Cc1ncc(CNc2cc(OC[C@@H]3C[C@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1 CHEMBL3894579 Ki 0.077 nM
CCc1nc(C2CC2)nc2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3695520 IC50 0.0777 nM
COc1cn(-c2ccc3c(c2F)C(C)(C)C(=O)N3CC2CC2)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3629735 IC50 0.08 nM
Cc1nnc(CNc2c(F)c(OC[C@H]3C[C@@H]3c3ccccn3)nc3ccnn23)s1 CHEMBL3695722 Ki 0.08 nM
Cc1nc(NCc2nnc(C)s2)cc(OC[C@H]2C[C@@H]2c2ccc(C3CC3)cn2)n1 CHEMBL3659074 Ki 0.08 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)s1 CHEMBL4113054 Ki 0.0819 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(C#N)n2)n1 CHEMBL4115603 Ki 0.085 nM
COCc1ccc(C(=O)C(C)(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 CHEMBL4113145 IC50 0.085 nM
c1ccc2nc(N3CC(c4nccnc4-c4cncnc4)C3)ccc2c1 CHEMBL3686943 IC50 0.0887 nM
Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)s1 CHEMBL4109656 Ki 0.089 nM
Cc1cccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C)c3)c(=O)n(C)n2)n1 CHEMBL4113684 Ki 0.089 nM
COc1cc(C(F)(F)F)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n12 CHEMBL1916130 IC50 0.09 nM
Cc1nnc(CNc2nc(N)nc(OC[C@H]3C[C@@H]3c3ccc4c(n3)CCC4)c2F)s1 CHEMBL3659072 Ki 0.09 nM
Cc1nc(C2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2[C@H](O)c2ccccc2)n1 CHEMBL4113817 Ki 0.09 nM
OCC1CCN(c2nccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)CC1 CHEMBL2206218 IC50 0.092 nM
O=C1CC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3694457 IC50 0.0957 nM
OCC1CCN(c2ncccc2Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)CC1 CHEMBL2206214 IC50 0.097 nM
Cc1cnc(CNc2cc(OC[C@H]3CC3c3ccn(C)n3)nn(C)c2=O)s1 CHEMBL4107617 Ki 0.097 nM
Cc1ccc2c(=O)n(-c3ccc(OC[18F])cc3)c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc2c1 CHEMBL5279257 Kd 0.097 nM
Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)n(C)n1 CHEMBL4108300 Ki 0.099 nM
COc1cc(N2CCOCC2)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n12 CHEMBL1916127 IC50 0.1 nM
Cc1ccc2c(=O)n(-c3ccc(O[11CH3])cc3)c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc2n1 CHEMBL2180402 Ki 0.1 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc3nc(C)ccc3c2=O)cc1 CHEMBL2180427 Ki 0.1 nM
Cn1ncc(C(=O)N2CCOCC2)c1C(=O)Nc1ccn2cc(-c3ccccc3)nc2c1 CHEMBL2180796 IC50 0.1 nM
Cc1ncc(C)n2nc(-c3ccn4cc(-c5ccccc5)nc4c3)nc12 CHEMBL2323965 IC50 0.1 nM
CC(=O)N1CCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3319210 IC50 0.1 nM
CC(=O)N1CCC(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3319209 IC50 0.1 nM
O=C(c1ccc(Oc2ncccc2C2CCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3319208 IC50 0.1 nM
CC(C)(O)CNC(=O)c1nc(C2CCCO2)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685595 IC50 0.1 nM
Cc1ccc2c(=O)n(-c3ccc4cn[nH]c4c3)c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc2c1 CHEMBL3644273 Ki 0.1 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc3cc(C)ccc3c2=O)cc1 CHEMBL3644271 Ki 0.1 nM
OCC1CCN(c2nccnc2C2CN(c3ccc4ccc(F)cc4n3)C2)CC1 CHEMBL3639903 IC50 0.1 nM
OCC1CCN(c2nccnc2C2CN(c3ncc4ccc(Cl)cc4n3)C2)CC1 CHEMBL3691498 IC50 0.1 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)s1 CHEMBL4110565 Ki 0.1 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1cc2nc(-c3ccccc3)cn2cc1Br CHEMBL4448109 IC50 0.1 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@H](O)CC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690350 IC50 0.101 nM
O=c1[nH]cc(-c2cccc(OC(F)(F)F)c2)nc1-c1ccnn1-c1ccccc1 CHEMBL5288570 IC50 0.102 nM
Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)s1 CHEMBL4109417 Ki 0.109 nM
Cc1nc(C)c(CNc2nc(OCCCc3ccc4cccnc4n3)nc(Cl)c2C)s1 CHEMBL3622903 Ki 0.11 nM
COc1cn(-c2ccc3c(c2F)C(C)(C)C(=O)N3C(C)C)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3627741 IC50 0.11 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4nn(C)c(C5CC5)c4C3)ncnn12 CHEMBL3691413 IC50 0.11 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3)n12 CHEMBL3742354 IC50 0.11 nM
Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3ccnn23)s1 CHEMBL3695717 Ki 0.11 nM
COc1ccc(Cc2nc(C)nn2-c2cc(/C=C/c3ccc(C)cn3)nc(C)n2)cc1OC CHEMBL3895140 Ki 0.11 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)O)cccc4n3)c(C)c12 CHEMBL3957024 IC50 0.11 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N5CC(F)C5)cccc4n3)c(C)c12 CHEMBL3930590 IC50 0.11 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N5CC(O)C5)cccc4n3)c(C)c12 CHEMBL3921648 IC50 0.11 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3cccnc23)s1 CHEMBL5424297 Ki 0.11 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C)c2C)nc1 CHEMBL4112092 Ki 0.113 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C#N)c(=O)n(C)c2C)nc1 CHEMBL4110950 Ki 0.117 nM
Cc1cnc(CNc2cc(OC[C@@H]3C[C@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1 CHEMBL3892294 Ki 0.118 nM
COc1cn(-c2ccc3c(c2F)C(C)(C)C(=O)N3C2CCC2)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3629734 IC50 0.12 nM
Cc1nc2ccc(F)cc2nc1-c1cc2nc(N3CC[C@H](F)C3)cc(N[C@H]3CC[C@@](C)(O)CC3)n2n1 CHEMBL3695922 IC50 0.12 nM
COc1cc(Br)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741950 IC50 0.12 nM
CCc1[nH]c(=O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12 CHEMBL3643826 IC50 0.12 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2Cc2ccc(F)cc2)n1 CHEMBL3901170 Ki 0.12 nM
COCc1cccc2nc(NC(=O)c3sc4c(C(C)=O)ccc(CO)c4c3C)ccc12 CHEMBL3972165 IC50 0.12 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3ccncc23)cn1 CHEMBL5400188 Ki 0.12 nM
COc1cnccc1-c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3n2C)cc1 CHEMBL3694472 IC50 0.121 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(C)nc3)c(=O)n(C)n2)nc1 CHEMBL4107568 Ki 0.121 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccnc(C)c3)c(=O)n(C)n2)nc1 CHEMBL4113100 Ki 0.122 nM
O=C1CCC(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690353 IC50 0.123 nM
FC(F)(F)c1ncccc1-c1nccnc1C1CN(c2ccc3ccccc3n2)C1 CHEMBL3686922 IC50 0.1236 nM
NC(=O)c1ccc(-c2cccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647630 IC50 0.129 nM
COc1cn(-c2ccc3c(c2F)C2(CCC2)C(=O)N3C)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3629733 IC50 0.13 nM
N#CC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687030 IC50 0.13 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(OCc3ccnn3C)n2)n1 CHEMBL3928715 Ki 0.13 nM
Cc1nc(C(C)O)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C3CC3)n2)n1 CHEMBL3890741 Ki 0.13 nM
CC([18F])C(=O)N1CCC(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL5268340 IC50 0.13 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3cnccc23)cn1 CHEMBL5431267 Ki 0.13 nM
C[C@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690314 IC50 0.135 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccnn3C)c(=O)n(C)n2)nc1 CHEMBL4107208 Ki 0.138 nM
COc1cc(OC)c2nc(C)c3c(C)nc(-c4cccnc4C)n3c2c1 CHEMBL1916125 IC50 0.14 nM
Cc1nc(C)c(CNc2cc(CCC#Cc3ccc4ccccc4n3)nc3ccnn23)s1 CHEMBL3695721 Ki 0.14 nM
COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc(C)cn3)nc(C)n2)cc1OC CHEMBL3931733 Ki 0.14 nM
Cc1ccc(CCc2cc(-n3nc(C)nc3C)nc(C)n2)nc1 CHEMBL3957122 Ki 0.14 nM
Cc1nc2ccc(F)cc2nc1/C=C/c1nc(NC2CCOCC2)cc(N2CCCC2)n1 CHEMBL4563588 IC50 0.14 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C(F)F)c3)c(=O)n(C)n2)nc1 CHEMBL4112170 Ki 0.144 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CCC[C@@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694444 IC50 0.145 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3627841 Ki 0.15 nM
Cc1nc2ccncc2nc1-c1cc2nc(N3CCCC3)cc(NC3CCOCC3)n2n1 CHEMBL3695932 IC50 0.15 nM
Cc1cc(Cl)c(C)n2nc(/C=C/c3nc(N4CCCC4)n(C)n3)nc12 CHEMBL3771125 IC50 0.15 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2C2=CCC(O)CC2)nc1 CHEMBL3699662 Ki 0.15 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 CHEMBL4108595 IC50 0.15 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(OC)c(=O)n(C)c2)nc1 CHEMBL4110140 Ki 0.1511 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)s1 CHEMBL4106622 Ki 0.157 nM
Cc1ncc(C)n2nc(-c3ccn4cc(-c5ccccn5)nc4c3)nc12 CHEMBL2323964 IC50 0.16 nM
Cc1ncc(C)n2nc(-c3ccn4cc(-c5cccc(N6CC[C@H](F)C6)c5)nc4c3)nc12 CHEMBL2323963 IC50 0.16 nM
O=C(c1ccc(Oc2ncccc2-c2cccnc2F)cc1)c1nc2ccccc2[nH]1 CHEMBL3694462 IC50 0.162 nM
CCOc1nc(C2CC2)nc2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3695528 IC50 0.166 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CC[C@@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690303 IC50 0.167 nM
O=C(c1ccc(Oc2ncccc2C(=O)NC2(Cc3ccccc3)CC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690256 IC50 0.168 nM
O=C1CC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3694479 IC50 0.169 nM
COc1nc(OC[C@H]2C[C@@H]2c2ccc3ncccc3n2)nc(NCc2cnn(C)c2)c1C CHEMBL3665950 Ki 0.17 nM
CSc1nc(OC[C@H]2C[C@@H]2c2ccccn2)nc(NCc2cnn(C)c2)c1C CHEMBL3665953 Ki 0.17 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(O)C2CC2)n1 CHEMBL3929295 Ki 0.17 nM
CC(=O)N1CCC(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3639891 IC50 0.175 nM
Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)s1 CHEMBL4107418 Ki 0.175 nM
Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)s1 CHEMBL4107666 Ki 0.176 nM
Cc1ccc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)cn1 CHEMBL3690238 IC50 0.177 nM
c1cncc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)c1 CHEMBL3690275 IC50 0.179 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc4ccccc4cn3)cc2)n1 CHEMBL1642569 IC50 0.18 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 CHEMBL562318 IC50 0.18 nM
Cc1nc(C)c(C2CC2)nc1-c1cc2nc(N3CCCC3)cc(NCC(C)(C)O)n2n1 CHEMBL3695926 IC50 0.18 nM
Cc1ncc(C)n2nc(CCc3cn4c(n3)-c3ccc(F)cc3C4)nc12 CHEMBL3659082 IC50 0.18 nM
Cc1nc(C)c(CNc2cc(C(=O)NC[C@H]3C[C@@H]3c3ccc4ccccc4n3)nc3ccnn23)s1 CHEMBL3695725 Ki 0.18 nM
FCCn1cc(-c2ccncc2)c(-c2ccc(OCc3ncc4ccccc4n3)cc2)n1 CHEMBL3899085 IC50 0.18 nM
COCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3892964 IC50 0.18 nM
Cc1nc([C@H]2CCOC2)c2c(N3CCc4c(c(C(C)C)nn4C)C3)ncnn12 CHEMBL3691454 IC50 0.182 nM
CCc1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cn(C)c1=O CHEMBL4114353 Ki 0.1851 nM
CC(C)Oc1cccc2c1C(=O)N(CCc1nc3ccccc3c(=O)n1-c1ccc(OCCF)cc1)C2=O CHEMBL3639431 Ki 0.19 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccnn3C)c(=O)n(C)n2)nc1 CHEMBL4114936 Ki 0.192 nM
CC(=O)N1CC=C(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690278 IC50 0.194 nM
CN1C[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1=O CHEMBL3690306 IC50 0.195 nM
Cn1cc(CNc2cc(OC[C@@H]3C[C@H]3c3nn(C)c4ccccc34)nn(C)c2=O)cn1 CHEMBL3916783 Ki 0.197 nM
OCC1CCN(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL2206221 IC50 0.199 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@H](CO)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690372 IC50 0.199 nM
COc1cc(OC)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL1916124 IC50 0.2 nM
Cc1cc(Cl)cc2c(C(O)c3ccncc3)c3c(C)n[nH]c3nc12 CHEMBL1950085 Ki 0.2 nM
CN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccn2cc(-c3ccccc3)nc2c1 CHEMBL2180795 IC50 0.2 nM
CNC(=O)c1nc(C2CCCO2)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685594 IC50 0.2 nM
CC(C)(O)CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1CC1CCCO1 CHEMBL3689976 IC50 0.2 nM
COC(=O)c1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686956 IC50 0.2 nM
FCCn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ncccc4n3)cc2)n1 CHEMBL3921723 IC50 0.2 nM
CSc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3917672 Ki 0.2 nM
CN1CC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1=O CHEMBL2180806 IC50 0.21 nM
O=c1ccc(-c2ccc(OCc3ccc4[nH]ccc4n3)cc2)c(-c2ccccc2)[nH]1 CHEMBL3634853 IC50 0.21 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C3CC3c3ccc(C)cn3)nc(C)n2)cc1OC CHEMBL3904978 Ki 0.21 nM
Cc1ccc(C2CC2c2cc(-n3nc(C)nc3Cc3ccccc3)nc(C)n2)nc1 CHEMBL3936634 Ki 0.21 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N5CCC5)cccc4n3)c(C)c12 CHEMBL3958084 IC50 0.21 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4ccc(C5CC5)nc4C3)ncnn12 CHEMBL3691443 IC50 0.211 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@@H](CO)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694425 IC50 0.212 nM
CC(=O)N1C=C(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CCC1 CHEMBL3690330 IC50 0.214 nM
Cc1ncc(-c2ccc(=O)n(-c3ccccc3)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4106745 Ki 0.216 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C)c2C)nc1 CHEMBL4112364 Ki 0.217 nM
CN1CCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CCC1=O CHEMBL3694443 IC50 0.218 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4nc(C5CC5)n(C)c(=O)c4C3)ncnn12 CHEMBL3695526 IC50 0.219 nM
Cc1ccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)cn1 CHEMBL3690267 IC50 0.219 nM
Cc1nc2ccccc2nc1OCc1cc(OC2CCOCC2)nc(N2CCCC2)n1 CHEMBL2180442 IC50 0.22 nM
COc1cn(-c2ccc3c(c2F)C(C)(C)C(=O)N3C)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3629732 IC50 0.22 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)c(C)nc2-c2cncc(OC)c2)nc1 CHEMBL3699660 Ki 0.22 nM
Cc1c(Cl)cc(Cl)c2nc(CCc3n[nH]c(N4CCCC4)n3)nn12 CHEMBL3899960 IC50 0.22 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N5CC(OC)C5)cccc4n3)c(C)c12 CHEMBL3953954 IC50 0.22 nM
CN(C)c1nc2ccccc2nc1/C=C/c1nc(NC2CCOCC2)cc(N2CCCC2)n1 CHEMBL5290355 IC50 0.22 nM
Cc1ncc(-c2cc(=O)n(C)cn2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 CHEMBL4115642 Ki 0.228 nM
COc1cn(-c2ccc(N3CCCC3)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3629542 IC50 0.23 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3ccnn23)cn1 CHEMBL3695713 Ki 0.23 nM
COc1ccc([C@H]2C[C@@H]2COc2nc3cccnc3cc2-c2cnn(CCO)c2)nc1 CHEMBL3699650 Ki 0.23 nM
Cc1c(Cl)cc(OC(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3939989 IC50 0.23 nM
COCCOc1cc(Cl)c(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc12 CHEMBL3985069 IC50 0.23 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2[C@@H](C)O)n1 CHEMBL4110385 Ki 0.23 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@H](O)C4)c4ccccc4n3)c(C)c12 CHEMBL3926858 IC50 0.23 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12 CHEMBL3908135 IC50 0.23 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CCOC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690291 IC50 0.232 nM
COc1cc2ccccc2nc1COc1ccc(-c2c(-c3ccncc3)cnn2C)cc1 CHEMBL3222273 IC50 0.24 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCOCCOCCF)c4ccccc4n3)cc2)n1 CHEMBL3628719 IC50 0.24 nM
c1ccc([C@H]2C[C@@H]2COc2cc(NCc3cn[nH]c3)n3nccc3n2)nc1 CHEMBL3695714 Ki 0.24 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2-c2c(F)cccc2F)n1 CHEMBL3957225 Ki 0.24 nM
Cn1c(Nc2ccc(Oc3ncccc3-c3cccnc3)cc2)nc2ccccc21 CHEMBL3690273 IC50 0.249 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cnn(C)c2)nc1 CHEMBL3699651 Ki 0.25 nM
O=C(c1ccc(Oc2ncccc2-c2ccncc2)cc1)c1nc2ccccc2[nH]1 CHEMBL3639890 IC50 0.256 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4c(c(C5CC5)nn4C)C3)ncnn12 CHEMBL3695564 IC50 0.257 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3nc4ccccc4cc3OCCF)cc2)n1 CHEMBL3628723 IC50 0.26 nM
O=C(c1ccc(Oc2ncccc2-c2cccnc2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690237 IC50 0.26 nM
NC(=O)c1ccc(-c2cccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)cn1 CHEMBL3647671 IC50 0.26 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2CN2CCCC2=O)n1 CHEMBL3963536 Ki 0.26 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(-n3ccnc3C)n2)n1 CHEMBL3907291 Ki 0.26 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N(C)C)cccc4n3)c(C)c12 CHEMBL3936013 IC50 0.26 nM
COc1cnccc1-c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3694447 IC50 0.261 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cccnc3)c(=O)n(C)n2)nc1 CHEMBL4111784 Ki 0.261 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4nn(C5CC5)cc4C3)ncnn12 CHEMBL3695563 IC50 0.265 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)c(C2CCOCC2)c1 CHEMBL3690280 IC50 0.267 nM
CC(=O)N1CCC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690332 IC50 0.268 nM
Cc1ncc(C)n2nc(CCc3c[nH]c(-c4ccoc4)n3)nc12 CHEMBL2180420 IC50 0.27 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCOCCF)c4ccccc4n3)cc2)n1 CHEMBL3628718 IC50 0.27 nM
Cc1nc2c(nc1-c1cc3nc(N4CCCC4)cc(N[C@H]4CC[C@](C)(O)CC4)n3n1)CCCO2 CHEMBL2180446 IC50 0.27 nM
O=C(c1ccc(Oc2ncccc2-c2cncnc2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690236 IC50 0.271 nM
CCOc1nc(C)nc2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691404 IC50 0.275 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cc(C)ccn3)c(=O)n(C)n2)nc1 CHEMBL4114189 Ki 0.276 nM
COc1nc(C)nc2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691406 IC50 0.277 nM
Cc1ccc2c(n1)CCN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)C2 CHEMBL3695522 IC50 0.279 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4Cl)n3c2c1 CHEMBL2069321 IC50 0.28 nM
COc1cc(COc2ccc(-c3nn(C)cc3-c3ccncc3)cc2)nc2ccccc12 CHEMBL3218037 IC50 0.28 nM
Cc1nc2cnccc2nc1-c1cc2nc(N3CCCC3)cc(NC3CCOCC3)n2n1 CHEMBL3695933 IC50 0.28 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12 CHEMBL3643869 IC50 0.28 nM
CC(C)Oc1cccc2c1C(=O)N(CCc1nc3ccccc3c(=O)n1-c1ccc(O)cc1)C2=O CHEMBL3644277 Ki 0.28 nM
CCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C(F)(F)F)n1 CHEMBL3958664 Ki 0.28 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(OCc3nccs3)n2)n1 CHEMBL3964101 Ki 0.28 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C#N)n2)n1 CHEMBL3909918 Ki 0.28 nM
Cc1cc(Cl)c(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc12 CHEMBL3964469 IC50 0.28 nM
COC(=O)Cn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cc1=O CHEMBL4109378 Ki 0.284 nM
O[C@@H]1CC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690334 IC50 0.286 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4cc(F)ccc4n3)cc2)n1 CHEMBL3628724 IC50 0.29 nM
COc1ccc2c(c1)Cn1cc(CCc3nc4c(C)ncc(C)n4n3)nc1-2 CHEMBL3659085 IC50 0.29 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(N3CCCC3)n2)n1 CHEMBL3905446 Ki 0.29 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)nn3-c3ccccc3)nc12 CHEMBL3974163 IC50 0.29 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)C4)c4ccccc4n3)c(C)c12 CHEMBL3940463 IC50 0.29 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4ccc(C(F)(F)F)nc4C3)ncnn12 CHEMBL3695537 IC50 0.295 nM
CCc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)n(C)n1 CHEMBL4110060 Ki 0.295 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CC(F)(F)F)c(=O)c2)nc1 CHEMBL4108695 Ki 0.299 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NC(Cc3cccnc3)C(=O)O)c2C#N)cc1 CHEMBL247159 IC50 0.3 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(C(F)c3ccncc3)c2c1 CHEMBL1950084 Ki 0.3 nM
FC(F)(F)Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 CHEMBL562513 IC50 0.3 nM
Cc1cnc2c(-c3ccc(Oc4ncccc4-c4ccncc4)cc3)cn(C)c2c1 CHEMBL3315045 IC50 0.3 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1 CHEMBL3628998 IC50 0.3 nM
O=c1ccc(-c2ccc(OCc3ccc4[nH]ccc4n3)cc2)c(-c2ccc(Cl)cc2)[nH]1 CHEMBL3634855 IC50 0.3 nM
Cc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)n1 CHEMBL3685600 IC50 0.3 nM
CC(C)(CO)NC(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690003 IC50 0.3 nM
CNC(=O)c1c(F)cc(F)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690027 IC50 0.3 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OCC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12 CHEMBL3643905 IC50 0.3 nM
Cc1ncsc1CNc1nc(-n2ncc3cnccc32)nc(N)c1Br CHEMBL3986072 IC50 0.3 nM
COC1=CN(c2ccc(-n3cccn3)cc2F)N=C(c2ccnn2-c2ccccc2)C1O CHEMBL4445635 IC50 0.3 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c(-c2cncnc2)c1 CHEMBL3690214 IC50 0.303 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@@H](O)CC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690349 IC50 0.308 nM
COCc1ccc(C(=O)C(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 CHEMBL4112997 IC50 0.31 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N5CCN(C)CC5)cccc4n3)c(C)c12 CHEMBL3969138 IC50 0.31 nM
O=C(c1ccc(Oc2ncccc2C2(F)CCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690300 IC50 0.311 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CC[C@H](CO)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690371 IC50 0.312 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CC[C@@H](CO)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690370 IC50 0.315 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc2c1 CHEMBL2180413 IC50 0.32 nM
Cc1ccc(C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc12 CHEMBL2180411 IC50 0.32 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCF)c4ccccc4n3)cc2)n1 CHEMBL3628716 IC50 0.32 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCOCCOCCOCCF)c4ccccc4n3)cc2)n1 CHEMBL3628720 IC50 0.33 nM
O=c1ccc(-c2ccc(OCc3ccc4[nH]ccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1 CHEMBL3634854 IC50 0.33 nM
COc1cc(-c2ccc(F)nc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3)n12 CHEMBL3739783 IC50 0.33 nM
Cc1ncc(C)n2nc(-c3ccn4cc(-c5cccc(C6CC6)c5)nc4c3)nc12 CHEMBL3703192 IC50 0.33 nM
COc1ccc(C)n2nc(CCc3nc(-c4cccs4)cn3CCN3CCOCC3)nc12 CHEMBL3668977 IC50 0.33 nM
Cc1nc(NCc2nnc(C)s2)cc(OC[C@H]2C[C@@H]2c2ccccn2)n1 CHEMBL5414603 Ki 0.33 nM
CNc1ccc2c(n1)CCN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)C2 CHEMBL3695532 IC50 0.333 nM
Cc1ccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4n3C)cc2)cn1 CHEMBL3690274 IC50 0.338 nM
Cc1ncc(C)n2nc(CCc3c[nH]c(-c4cccs4)n3)nc12 CHEMBL2180419 IC50 0.34 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 CHEMBL3639427 IC50 0.34 nM
Cc1ccc(C)n2nc(CCc3c[nH]c(-c4cccs4)n3)nc12 CHEMBL3681987 IC50 0.34 nM
COc1ccc([C@H]2C[C@@H]2COc2ncc(C)cc2-c2cnn3c2CCC3)nc1 CHEMBL3699661 Ki 0.34 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)cn1 CHEMBL4115215 Ki 0.34 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(O)C(C)C)n1 CHEMBL3895961 Ki 0.34 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(O)CF)n1 CHEMBL3938187 Ki 0.34 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12 CHEMBL3965651 IC50 0.34 nM
O=C(c1ccc(Oc2ncccc2-c2cccc3ncccc23)cc1)c1nc2ccccc2[nH]1 CHEMBL3690252 IC50 0.342 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cnn(CC5CCC5)c4C3)ncnn12 CHEMBL3695552 IC50 0.345 nM
CCc1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)cn(C)c1=O CHEMBL4112476 Ki 0.347 nM
COc1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)cn(C)c1=O CHEMBL4115653 Ki 0.349 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccccc3C)n12 CHEMBL1916117 IC50 0.35 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2-c2ccccc2Cl)n1 CHEMBL3907196 Ki 0.35 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C3CCOCC3)nn12 CHEMBL3891928 IC50 0.35 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)CC4)c4ccccc4n3)c(C)c12 CHEMBL3922429 IC50 0.35 nM
COc1cc(COc2ccc(-c3c(-c4ccncc4)cnn3C)cc2)nc2ccccc12 CHEMBL3222274 IC50 0.36 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1 CHEMBL3628996 IC50 0.36 nM
Cc1c(Cl)cc(OC2CCOCC2)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3954232 IC50 0.36 nM
Cc1nc([C@H](C)O)n(-c2cc(C3C[C@H]3c3nc4ccccc4n3C)nc(C3CC3)n2)n1 CHEMBL3892150 Ki 0.36 nM
Cc1ncc(C)n2nc(/C=C/c3nc(N4CCCC4)cc(N4CCOCC4)n3)nc12 CHEMBL5186554 Ki 0.36 nM
CC(=O)N1CC=C(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690277 IC50 0.363 nM
Cc1nc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)sc1C CHEMBL4107305 Ki 0.368 nM
Cc1nc(C)c(CNc2nc(OCCCc3cnc4ccccc4n3)nc(Cl)c2C)s1 CHEMBL3622904 Ki 0.37 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OC(C)C)c4C3=O)nc3ncccc3c2=O)cc1 CHEMBL3627845 Ki 0.37 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1 CHEMBL3628999 IC50 0.37 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4o3)cc2)c(C2CCOCC2)c1 CHEMBL3694474 IC50 0.37 nM
COc1ccc(CCCCc2cc(NCc3sc(C)nc3C)n3nccc3n2)nc1 CHEMBL3695719 Ki 0.37 nM
CSc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL4109746 Ki 0.37 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(N3CCC[C@H]3C)n2)n1 CHEMBL4108151 Ki 0.37 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)CCC(=O)O)cccc4n3)c(C)c12 CHEMBL3899426 IC50 0.37 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CC3CC3)c2)nc1 CHEMBL4108892 Ki 0.377 nM
Cc1ncc(-c2ccn(C)c(=O)c2)c(OC[C@H]2C[C@@H]2c2ccc3c(n2)CCC3)n1 CHEMBL4111975 Ki 0.378 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3c(C)noc3C)c(=O)n(C)n2)nc1 CHEMBL4109029 Ki 0.38 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(OC(C)C)n2)n1 CHEMBL3910784 Ki 0.38 nM
COCc1cccc2nc(NC(=O)c3sc4c(C(C)=O)ccc(COC)c4c3C)ccc12 CHEMBL3939586 IC50 0.38 nM
CCn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cc(C)c1=O CHEMBL4113855 Ki 0.381 nM
COc1cnc2c(c1)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691398 IC50 0.384 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CC(F)F)c(=O)c2)nc1 CHEMBL4112253 Ki 0.386 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)nn1-c1ccccc1 CHEMBL3649574 IC50 0.39 nM
Cc1ncc(C)n2nc(CCc3nc(-c4cccs4)cn3C)nc12 CHEMBL3668981 IC50 0.39 nM
COc1ccc(C2CC2c2cc(-n3nc(C)nc3Cc3ccc(OC)c(OC)c3)nc(C)n2)nc1 CHEMBL3934159 Ki 0.39 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)[nH]cc2Cl)nc1 CHEMBL4109837 Ki 0.39 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC(O)C5)cccc4n3)c(C)c12 CHEMBL3934797 IC50 0.39 nM
COC(=O)Cn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)cc1=O CHEMBL4111306 Ki 0.394 nM
Cc1cc(Cl)cc2c(C(O)c3ncco3)c3c(C)n[nH]c3nc12 CHEMBL1950089 Ki 0.4 nM
COc1cc2ccccc2nc1COc1ccc(-c2nn(C)cc2-c2ccncc2)cc1 CHEMBL3218036 IC50 0.4 nM
Cc1nc(C)c(CNc2nc(CCCCc3ccccn3)nc(Cl)c2C)s1 CHEMBL3746162 Ki 0.4 nM
O=C(Nc1cnccc1C(=O)N1CC(O)C1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685505 IC50 0.4 nM
O=C(Nc1sccc1C(=O)N1CCOCC1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685513 IC50 0.4 nM
CC(C)(O)CNC(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685521 IC50 0.4 nM
CC(C)(O)CNC(=O)c1cnccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685543 IC50 0.4 nM
CC(C)(O)CNC(=O)c1nc(C2CC2)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685577 IC50 0.4 nM
CCc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)n1 CHEMBL3685598 IC50 0.4 nM
O=C(NCCO)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3639888 IC50 0.4 nM
CNC(=O)c1cc(NC(C)=O)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690004 IC50 0.4 nM
CC1(NC(=O)c2ncccc2NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)COC1 CHEMBL3690005 IC50 0.4 nM
CC(C)(O)CNC(=O)c1ccc(F)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690029 IC50 0.4 nM
CNC(=O)c1cc(CCC(=O)O)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690056 IC50 0.4 nM
CCNc1nc2ccc(OC)cc2cc1Cc1c(=O)[nH]c(CC)c2cc(OC)c(OC)cc12 CHEMBL3643860 IC50 0.4 nM
CCc1[nH]c(=O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12 CHEMBL3643904 IC50 0.4 nM
Cc1ncc(C)n2nc(CCc3cn4c(n3)-c3ccccc3C4)nc12 CHEMBL3698371 IC50 0.4 nM
Cc1ccc(C)n2nc(CCc3nc(-c4cscn4)cn3C)nc12 CHEMBL3668993 IC50 0.4 nM
CCc1nc(C)nn1-c1cc([C@@H]2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL4107645 Ki 0.4 nM
COCCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)cc1=O CHEMBL4115495 Ki 0.4 nM
CCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(OC)n1 CHEMBL3943656 Ki 0.4 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(OCc3ccno3)n2)n1 CHEMBL3973656 Ki 0.4 nM
Cc1ncsc1CNc1nc(-n2ncc3ccncc32)nc(N)c1Br CHEMBL3944294 IC50 0.4 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CCC[C@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690297 IC50 0.405 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690304 IC50 0.405 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4noc(C5CC5)c4C3)ncnn12 CHEMBL3695558 IC50 0.406 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C)c(=O)n(C)c2)nc1 CHEMBL4111066 Ki 0.409 nM
COc1cc(-c2ccc(F)nc2)cc2c1nc(C)c1c(C)nc(-c3ccncc3)n12 CHEMBL3741781 IC50 0.41 nM
Cn1cc(-c2ccccc2)nc1CCn1nc2cccc(N3CCOCC3)n2c1=O CHEMBL3933011 Ki 0.41 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(C)c(C)n3)c(=O)n(C)n2)nc1 CHEMBL4109227 Ki 0.41 nM
CCCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C)n1 CHEMBL3922316 Ki 0.41 nM
CCC(O)c1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C)n1 CHEMBL3909277 Ki 0.41 nM
O=C(c1nc2ccccc2[nH]1)C1CC(Oc2ncccc2C2CCOCC2)C1 CHEMBL3925068 IC50 0.413 nM
COc1cccc2[nH]c(Nc3ccc(Oc4ncccc4C4CCOCC4)cc3)nc12 CHEMBL3694426 IC50 0.418 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(OC3CCC3)n2)n1 CHEMBL4108605 Ki 0.42 nM
COc1cc2cncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC CHEMBL3913232 IC50 0.42 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N5CC(F)(F)C5)cccc4n3)c(C)c12 CHEMBL3946008 IC50 0.42 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C#N)c(=O)n(C)c2C)nc1 CHEMBL4114545 Ki 0.426 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cnn(C5CC5)c4C3)ncnn12 CHEMBL3695557 IC50 0.427 nM
COC[C@H](C)Oc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)c1ncn3ccccc13)CC2 CHEMBL3659652 Ki 0.43 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c(C2CCOCC2)c1 CHEMBL3690292 IC50 0.436 nM
COc1ccc(-c2cc(N3CCn4ccnc4C3)nc(/C=C/c3nc(N(C)C)c4ccccc4n3)n2)cc1OC CHEMBL2180438 IC50 0.44 nM
Cc1c(Cl)nc(OC[C@H]2C[C@@H]2c2ccccn2)nc1NCc1cnn(C)c1 CHEMBL3665949 Ki 0.44 nM
COc1cccc2c1Cn1cc(CCc3nc4c(C)ncc(C)n4n3)nc1-2 CHEMBL3659088 IC50 0.44 nM
COc1cccc2c1-c1nc(CCc3nc4c(C)ncc(C)n4n3)cn1C2 CHEMBL3659089 IC50 0.44 nM
Cc1ncc(C)n2nc(CCc3nc(-c4cncnc4)cn3C)nc12 CHEMBL3668994 IC50 0.44 nM
COc1cc(Cl)c(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc12 CHEMBL3910147 IC50 0.44 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)n(C)n3)nn12 CHEMBL3957857 IC50 0.44 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(F)CC4)c4ccccc4n3)c(C)c12 CHEMBL3966121 IC50 0.44 nM
CCO[C@H](C(=O)c1ccc(-c2cc(OC)c(Cl)c(OC)c2)o1)c1ccc(-c2nnc(C)s2)cc1 CHEMBL3928735 IC50 0.44 nM
Cc1ccc2c(c1)nc(CCN1C(=O)c3cccc4cccc(c34)C1=O)n2-c1ccncc1 CHEMBL4558162 IC50 0.44 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CC#N)c(=O)c2)nc1 CHEMBL4109335 Ki 0.441 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c([C@@H]2CCOC2)c1 CHEMBL3690346 IC50 0.45 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N(C)C)c4ccccc4n3)c(C)c12 CHEMBL3904358 IC50 0.45 nM
C=CCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cc1=O CHEMBL4109640 Ki 0.458 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3ccnc(F)c3)n12 CHEMBL3741660 IC50 0.46 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C3CC3)n2)n1 CHEMBL3916699 Ki 0.46 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cc(C5CC5)ncc4C3)ncnn12 CHEMBL3695541 IC50 0.468 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1 CHEMBL3628997 IC50 0.47 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)nn1-c1ccccn1 CHEMBL3649576 IC50 0.47 nM
Cc1nc(C2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C(O)C(C)C)n1 CHEMBL4111186 Ki 0.47 nM
Cc1c(C(=O)Nc2cc(C(C)(C)O)c3ccccc3n2)sc2c(C(=O)C(C)C)cccc12 CHEMBL3905678 IC50 0.47 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)nc1 CHEMBL4111800 Ki 0.473 nM
O=C(c1ccc(Oc2ncccc2C2CCOCC2)cc1)c1nc2ccc(F)cc2[nH]1 CHEMBL3694464 IC50 0.475 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3c(Cl)c(C)nn3C)c(=O)n(C)n2)nc1 CHEMBL4107710 Ki 0.476 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)cn1 CHEMBL4113421 Ki 0.478 nM
CC(C)Oc1cccc2c1C(=O)N(CCc1nc3ncccc3c(=O)n1-c1ccc3cn[nH]c3c1)C2=O CHEMBL3644266 Ki 0.48 nM
NC(=O)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3691477 IC50 0.48 nM
Cc1c(Br)cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3961021 IC50 0.48 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)N5CCOCC5)cccc4n3)c(C)c12 CHEMBL3944954 IC50 0.48 nM
Cc1ncc(-c2ccc(=O)n(C)c2C)c(OC[C@H]2C[C@@H]2c2ccc3c(n2)CCC3)n1 CHEMBL4112616 Ki 0.481 nM
CCc1nn(C)c2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3639902 IC50 0.486 nM
OC1(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CCOCC1 CHEMBL3690299 IC50 0.49 nM
Cc1nc(C)c(CNc2nc(OC[C@H]3C[C@@H]3c3ccc4ncccc4n3)nc(Cl)c2C)o1 CHEMBL3665958 Ki 0.49 nM
CCOc1nc(C)nn1-c1cc([C@@H]2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL4108200 Ki 0.49 nM
COC(=O)CCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C)n1 CHEMBL3950441 Ki 0.49 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(OCc3ccon3)n2)n1 CHEMBL3896266 Ki 0.49 nM
COCc1nc(C)nn1-c1cc(C2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL4112279 Ki 0.49 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC(O)C4)c4ccccc4n3)c(C)c12 CHEMBL3936282 IC50 0.49 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3ccccc23)cn1 CHEMBL5420678 Ki 0.49 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cc2C)nc1 CHEMBL4110492 Ki 0.496 nM
COc1cc(OC)c2nc(C)c3c(C)nc(-c4cnccc4C)n3c2c1 CHEMBL1916123 IC50 0.5 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(N3CCC(CN)CC3)c2c1 CHEMBL1939796 Ki 0.5 nM
COc1nc2cccnc2n1-c1ccc(Nc2nc3ccccc3[nH]2)cc1 CHEMBL3287658 IC50 0.5 nM
CNC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccc(F)cc4n3)C2)cc1F CHEMBL3675651 IC50 0.5 nM
O=C(NC1CC1)c1ccsc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685512 IC50 0.5 nM
COCc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)n1 CHEMBL3685625 IC50 0.5 nM
CC(C)(O)CNC(=O)c1cc(OCCO)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689947 IC50 0.5 nM
CNC(=O)c1cc(OC)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689957 IC50 0.5 nM
CCCc1[nH]c(=O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12 CHEMBL3643827 IC50 0.5 nM
CCCNc1nc2ccc(OC)cc2cc1Cc1c(=O)[nH]c(CC)c2cc(OC)c(OC)cc12 CHEMBL3643862 IC50 0.5 nM
OCC1CCN(c2nccnc2C2CN(c3cnc4ccc(Cl)cc4n3)C2)CC1 CHEMBL3691500 IC50 0.5 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(N)nc(NCc3nnc(C)s3)c2F)nc1 CHEMBL3659070 Ki 0.5 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C3CC3c3cc4n(n3)CCC4)nc(C)n2)cc1OC CHEMBL3906186 Ki 0.5 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3960059 IC50 0.5 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCCC(O)C4)c4ccccc4n3)c(C)c12 CHEMBL3973207 IC50 0.5 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](F)C4)c4ccccc4n3)c(C)c12 CHEMBL4114615 IC50 0.5 nM
[18F]CCn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 CHEMBL1915747 IC50 0.5 nM
Cc1cc(-c2ccncc2)n(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 CHEMBL5271175 IC50 0.5 nM
COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)cc1 CHEMBL4108030 Ki 0.502 nM
C=CCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)cc1=O CHEMBL4113104 Ki 0.508 nM
Cn1c(C(=O)c2ccc(Oc3ncccc3C3CCOCC3)cc2)nc2ccccc21 CHEMBL3690309 IC50 0.509 nM
Cc1c(Cl)cc(OCC(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3893837 IC50 0.51 nM
OCC1CCN(c2nccnc2Oc2ccc(Nc3nc4ccccc4o3)cc2)CC1 CHEMBL2206220 IC50 0.513 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C3CC3)c2)nc1 CHEMBL4111612 Ki 0.519 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(NCCF)c4ccccc4n3)cc2)n1 CHEMBL3628721 IC50 0.52 nM
COC(=O)N(C)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687054 IC50 0.52 nM
Cc1ncc(C)n2nc(CCc3nc(-c4cnccn4)cn3C)nc12 CHEMBL3668995 IC50 0.52 nM
OCC1CCN(c2ncncc2Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)CC1 CHEMBL2206216 IC50 0.521 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CCCOC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690327 IC50 0.521 nM
C[C@@]1(O)CC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690368 IC50 0.524 nM
CC(=O)N1CC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3694455 IC50 0.528 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)nn1-c1cccnc1 CHEMBL3649578 IC50 0.53 nM
CCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3976592 IC50 0.53 nM
Cc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C3CC3)n2)c1 CHEMBL3911235 Ki 0.53 nM
Cc1nc(C(C)O)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)n1 CHEMBL3895653 Ki 0.53 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(C)O)cccc4n3)c(C)c12 CHEMBL3917898 IC50 0.53 nM
Cc1ncc(-c2ccc(=O)n(C)c2)c(OC[C@H]2C[C@@H]2c2ccc3c(n2)CCC3)n1 CHEMBL4113566 Ki 0.531 nM
CCn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)cc(C)c1=O CHEMBL4114963 Ki 0.533 nM
CN1C[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1=O CHEMBL3690362 IC50 0.534 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)s1 CHEMBL4112387 Ki 0.535 nM
Cc1ccc2c(n1)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691441 IC50 0.539 nM
O=c1ccc(-c2ccc(OCc3ccc4[nH]ccc4n3)cc2)c(-c2ccncc2)[nH]1 CHEMBL3634856 IC50 0.54 nM
Cc1cccc2nc(CCc3nc(-c4cccs4)c[nH]3)nn12 CHEMBL3668915 IC50 0.54 nM
CCOc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL4108061 Ki 0.54 nM
Cc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C3CC3)n2)n1 CHEMBL3969592 Ki 0.54 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COCCO)cccc4n3)c(C)c12 CHEMBL3902536 IC50 0.54 nM
C[C@@H](Cc1ccccn1)NC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690246 IC50 0.541 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n12 CHEMBL1916114 IC50 0.55 nM
Cc1ncc(C)n2nc(CCc3nc(-c4ccncc4)cn3C)nc12 CHEMBL3668996 IC50 0.55 nM
Cc1c(Cl)cc(OC(F)F)c2nc(CCc3nc(N4CCCC4)n(C)n3)nn12 CHEMBL3930363 IC50 0.55 nM
CCC(O)c1nc(C)nn1-c1cc(C2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL4107580 Ki 0.55 nM
Cc1nc(C2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C(O)C(F)(F)F)n1 CHEMBL4109476 Ki 0.55 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690313 IC50 0.551 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)cn1 CHEMBL4108370 Ki 0.552 nM
COCCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cc1=O CHEMBL4113991 Ki 0.553 nM
N#Cc1ccc(-c2cccnc2O[C@H]2C[C@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647628 IC50 0.56 nM
CCc1nc(C)nc2c1CN(c1ncnn3c(C)nc(-c4ccccc4F)c13)CC2 CHEMBL3695515 IC50 0.573 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(N3CC[C@@H](F)C3)n2)n1 CHEMBL4110889 Ki 0.58 nM
Cc1cc(Cl)c(C)n2nc(CCc3nc(N4CCCC4)n(C)n3)nc12 CHEMBL3943753 IC50 0.58 nM
COc1nccc2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691397 IC50 0.582 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CCOC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690343 IC50 0.582 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cc2C2CC2)nc1 CHEMBL4109637 Ki 0.583 nM
CCC(O)c1nc(C)nn1-c1cc([C@@H]2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL4106724 Ki 0.59 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOC(CO)C3)c2c1 CHEMBL1939916 Ki 0.6 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(NCc3ccncc3)c2c1 CHEMBL1939800 Ki 0.6 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(C(O)c3ncco3)c2c1 CHEMBL1949940 Ki 0.6 nM
Cc1ccncc1NC(=O)N1CCc2nc(-c3ccc(Cl)nc3)nc(OC(C)C)c2C1 CHEMBL2204542 Ki 0.6 nM
Cc1nc(C)c(-c2cc3nc(N4CCCC4)cc(NCC(C)(C)O)n3n2)nc1CC(C)C CHEMBL3695925 IC50 0.6 nM
Cc1ccc(NC(=O)N2CCc3nc(-c4ccc(Cl)nc4)nc(OC(C)C)c3C2)cn1 CHEMBL3659654 Ki 0.6 nM
CC(C)(O)CNC(=O)c1cc(F)c(F)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685533 IC50 0.6 nM
Cc1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)n1 CHEMBL3690010 IC50 0.6 nM
CCOC(=O)CCc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NC)c1 CHEMBL3690049 IC50 0.6 nM
CC(=O)N1CC=C(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3691485 IC50 0.6 nM
NC(=O)c1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccc1F CHEMBL3691520 IC50 0.6 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2/C=C/c2cccnc2)nc1 CHEMBL3699654 Ki 0.6 nM
Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4ccccc4n3)nc(C)n2)n(C)n1 CHEMBL3659060 Ki 0.6 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccc2nc(-c3ccccc3)nn2c1 CHEMBL3962845 IC50 0.6 nM
Cc1ncsc1CNc1nc(-n2ncc3ncccc32)nc(N)c1Br CHEMBL3966826 IC50 0.6 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COP(=O)(O)O)cccc4n3)c(C)c12 CHEMBL3916208 IC50 0.6 nM
O=C(O)c1ccc(-c2c([C@H]3C[C@H](c4ccc5ccccc5n4)C3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3892809 IC50 0.6 nM
Cc1nc2ccccc2nc1OCc1nc(OC2CCOCC2)cc(N2CCCC2)n1 CHEMBL2180443 IC50 0.61 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cnn(C(C)C)c4C3)ncnn12 CHEMBL3691460 IC50 0.61 nM
Cc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)c1 CHEMBL3925656 Ki 0.61 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(-n3cccn3)n2)n1 CHEMBL3945114 Ki 0.61 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)[nH]cc2C)nc1 CHEMBL4107448 Ki 0.612 nM
Cc1ccc(C)n2nc(CCc3c[nH]c(-c4ccco4)n3)nc12 CHEMBL3681989 IC50 0.62 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(OC(C)C)n2)n1 CHEMBL3978832 Ki 0.62 nM
Cc1nc(C2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2[C@@H](O)c2ccccc2)n1 CHEMBL4113138 Ki 0.62 nM
CCOC(C(=O)c1ccc(-c2cc(OC)c(Cl)c(OC)c2)o1)c1ccc(-c2nnc(C)s2)cc1 CHEMBL3964627 IC50 0.62 nM
COc1cncc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)c1 CHEMBL3690316 IC50 0.622 nM
CCc1nc(C)nc2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3695516 IC50 0.625 nM
CC(C)Oc1nc(-c2ccc(Cl)nc2)nc2c1CN(S(=O)(=O)c1cccnc1)CC2 CHEMBL2180422 Ki 0.63 nM
Cc1ncc(C)n2nc(CCc3c[nH]c(-c4nccs4)n3)nc12 CHEMBL3681991 IC50 0.63 nM
FCCn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 CHEMBL1915748 IC50 0.63 nM
COC[C@@H](C)Oc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL4111026 Ki 0.63 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2cc(C)c(C)n2)n1 CHEMBL3976868 Ki 0.63 nM
Cc1c(Cl)cc(Cl)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3926789 IC50 0.63 nM
O=C(c1ccc(Oc2ncccc2C2CCS(=O)(=O)CC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694468 IC50 0.631 nM
CC(=O)Nc1cccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)c1 CHEMBL3687063 IC50 0.635 nM
CCCc1cnc(C)c(-c2cc3nc(N4CCCC4)cc(N(C)C4CCOCC4)n3n2)n1 CHEMBL3695923 IC50 0.64 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CCO)c(=O)c2)nc1 CHEMBL4110726 Ki 0.64 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@]3(CCO3)CC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690363 IC50 0.641 nM
CN1CC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1=O CHEMBL3690335 IC50 0.644 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C)n3)c(=O)n(C)n2)nc1 CHEMBL4108556 Ki 0.648 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(COCCF)c4ccccc4n3)cc2)n1 CHEMBL3628717 IC50 0.65 nM
Cc1ccc(C)n2nc(CCc3c[nH]c(-c4ccoc4)n3)nc12 CHEMBL3681990 IC50 0.65 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2ccc(C(C)C)n2)n1 CHEMBL3971890 Ki 0.65 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(O)C(F)F)n1 CHEMBL3925729 Ki 0.65 nM
C[C@]1(O)CC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690366 IC50 0.662 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4cnn(C(C)C)c4C3)ncnn12 CHEMBL3691461 IC50 0.664 nM
O=C(c1ccc(Oc2ncccc2-c2ccnc3ccccc23)cc1)c1nc2ccccc2[nH]1 CHEMBL3690255 IC50 0.67 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2cccc(F)c2)nn1-c1ccccc1 CHEMBL3649579 IC50 0.67 nM
Cc1c(C(=O)Nc2cc(C(C)(C)O)c3ccccc3n2)sc2c(C(=O)C3CCC3)cccc12 CHEMBL3894275 IC50 0.67 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CC[C@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690310 IC50 0.675 nM
CC[C@]1(O)CC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690360 IC50 0.679 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(CF)c4ccccc4n3)cc2)n1 CHEMBL3628714 IC50 0.68 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(C3CC3)n2)n1 CHEMBL3956689 Ki 0.68 nM
Cc1nc(C)c(C2CC2)nc1-c1cc2nc(N3CCCC3)cc(NC3CCOCC3)n2n1 CHEMBL3695927 IC50 0.69 nM
CCCn1cc(-c2ccccc2)nc1CCc1nc2nc(C)cc(C)n2n1 CHEMBL3640024 IC50 0.69 nM
Cc1ccc(C)n2nc(CCc3cn4c(n3)-c3ccccc3C4)nc12 CHEMBL3698372 IC50 0.69 nM
Cn1c(C(=O)c2ccc(Oc3ncccc3C3=CCOCC3)cc2)nc2ccccc21 CHEMBL3690308 IC50 0.692 nM
COc1ccc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)c(OC)n1 CHEMBL3694465 IC50 0.694 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n12 CHEMBL1916113 IC50 0.7 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(Cl)cc(C(F)(F)F)cc3n12 CHEMBL1916132 IC50 0.7 nM
COc1cc(OCc2ccccc2)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2180775 IC50 0.7 nM
COCCOc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)c1 CHEMBL3689945 IC50 0.7 nM
CC(C)(O)CNC(=O)c1cc(C#N)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689993 IC50 0.7 nM
CNC(=O)c1ccc(F)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690020 IC50 0.7 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)oc1-c1ccccc1 CHEMBL3649577 IC50 0.7 nM
COc1ccc2c(=O)n(-c3cccc(C)c3)c(CCN3C(=O)c4cccc(OC)c4C3=O)nc2c1 CHEMBL3644260 Ki 0.7 nM
CNC(=O)c1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3675659 IC50 0.7 nM
CC(C)(C)OC(=O)N1CC=C(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3686966 IC50 0.7 nM
Cc1noc(COc2nc(N3CC(c4nc5ccccc5n4C)C3)cc(-n3nc(C)nc3C)n2)n1 CHEMBL3934150 Ki 0.7 nM
CC(C)(C)OC(=O)N1CCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3694484 IC50 0.702 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccccn3)c(=O)n(C)n2)nc1 CHEMBL4109288 Ki 0.706 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(F)c4ccccc4n3)cc2)n1 CHEMBL3628713 IC50 0.71 nM
COc1cc2c(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)cnc(C)c2cc1OC CHEMBL3948807 IC50 0.71 nM
COc1ccc(Cn2nc(N3CCCC3)nc2CCc2nc3c(Cl)cc(Cl)c(C)n3n2)cc1 CHEMBL3956484 IC50 0.72 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C3CC3)nn12 CHEMBL3962789 IC50 0.72 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C)c(=O)n(C)c2)nc1 CHEMBL4109787 Ki 0.727 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@@](O)(C(F)(F)F)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690358 IC50 0.728 nM
N#C[C@@H]1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647656 IC50 0.728 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cnn(C)c(=O)c2Cl)nc1 CHEMBL4115562 Ki 0.728 nM
Cn1ccc2nc(COc3ccc(-c4ccc(=O)[nH]c4-c4ccc(Cl)cc4)cc3)ccc21 CHEMBL3634858 IC50 0.73 nM
O[C@H]1CCC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3694440 IC50 0.737 nM
Cc1cc(-c2cc(Cl)cnc2Oc2ccc(C(=O)c3nc4ccccc4n3C)cc2)ccn1 CHEMBL3694490 IC50 0.738 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CC(F)(F)F)c(=O)c2)nc1 CHEMBL4111754 Ki 0.74 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2ccc(C3CC3)n2)n1 CHEMBL3905171 Ki 0.74 nM
Cc1nc(C2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2[C@H](C)O)n1 CHEMBL3962106 Ki 0.74 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@@H](N)CO)cccc4n3)c(C)c12 CHEMBL3930964 IC50 0.74 nM
COc1cnccc1-c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 CHEMBL3694473 IC50 0.747 nM
Cn1c(C(=O)c2ccc(Oc3ncccc3C3(F)CCOCC3)cc2)nc2ccccc21 CHEMBL3690331 IC50 0.749 nM
Cc1ccc(C)n2nc(CCc3cn(C)c(-c4ccco4)n3)nc12 CHEMBL3681986 IC50 0.75 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(N3CC(F)(F)C3)n2)n1 CHEMBL4113388 Ki 0.75 nM
CCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cc1=O CHEMBL4113082 Ki 0.75 nM
COCCOCc1cccc2nc(NC(=O)c3sc4c(C(C)=O)ccc(COC)c4c3C)ccc12 CHEMBL3918118 IC50 0.75 nM
c1cnc(O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)c(C2CCOCC2)c1 CHEMBL3647603 IC50 0.751 nM
O=C(c1ccc(Oc2ncccc2C2=CCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690254 IC50 0.752 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cnn(CC(C)C)c4C3)ncnn12 CHEMBL3695548 IC50 0.755 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1 CHEMBL3629001 IC50 0.76 nM
O=c1c(OCCN2CCn3c2nc2ccccc23)cn(CC2CC2)nc1-c1ccnn1-c1ccccc1 CHEMBL3814662 IC50 0.76 nM
Cc1cc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)ccn1 CHEMBL3690200 IC50 0.76 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2ccc(C(F)(F)F)n2)n1 CHEMBL3959740 Ki 0.76 nM
COc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3948975 Ki 0.76 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC[C@@H](O)C5)cccc4n3)c(C)c12 CHEMBL4110979 IC50 0.76 nM
Cc1ccc2c(c1)nc(CCN1C(=O)c3cccc4cccc(c34)C1=O)n2-c1ccccc1 CHEMBL4527952 IC50 0.76 nM
C[C@]1(O)CC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690367 IC50 0.763 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(Cl)c(C)c(NCc3cnn(C)n3)n2)nc1 CHEMBL3665960 Ki 0.77 nM
CNc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL4107845 Ki 0.77 nM
[11CH3]Oc1cn(-c2ccc(C3CCOCC3)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL5272386 IC50 0.77 nM
COc1cn(-c2ccc(C3CCOCC3)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL5289746 IC50 0.77 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2csc(C)n2)nc1 CHEMBL3699663 Ki 0.78 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)nc1 CHEMBL4111621 Ki 0.782 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cccnc4C3)ncnn12 CHEMBL3695555 IC50 0.785 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C)n(C)c(=O)c2)nc1 CHEMBL4111151 Ki 0.785 nM
COc1cn(-c2ccc(N3CCCC3=O)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3629541 IC50 0.79 nM
Cc1ncc(C)n2nc(CCc3cn4c(n3)-c3c(F)cccc3C4)nc12 CHEMBL3659087 IC50 0.79 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OCC(F)(F)F)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3644267 Ki 0.79 nM
COc1cc(Cl)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL1916131 IC50 0.8 nM
COc1cc2nncc(-c3cnc(N[C@@H](C)Cc4ccccn4)c(C)c3)c2cc1OC CHEMBL2070528 IC50 0.8 nM
COc1nc2cccnc2n1[C@H]1C[C@H](Nc2nc3ccccc3s2)C1 CHEMBL3287907 IC50 0.8 nM
O=C(c1ccc(Oc2nccnc2C2CCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3319207 IC50 0.8 nM
COc1ccc2[nH]c(C(=O)N3CCc4nc(-c5cccnc5)nc(OC(C)C)c4C3)cc2n1 CHEMBL3659658 Ki 0.8 nM
CNC(=O)c1nc(C2CC2)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685576 IC50 0.8 nM
CNC(=O)c1cc(OCCO)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689948 IC50 0.8 nM
CNC(=O)c1cc(F)c(F)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690016 IC50 0.8 nM
CNC(=O)c1cc(F)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690040 IC50 0.8 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)N1CCCO1 CHEMBL3690063 IC50 0.8 nM
O=C(c1ccc(Oc2ncccc2-c2ccnc(F)c2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694435 IC50 0.8 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NC(C)C)c2cc(OC)c(OC)cc12 CHEMBL3643872 IC50 0.8 nM
NC(=O)c1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3691519 IC50 0.8 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(C)nc2)nc1 CHEMBL3699658 Ki 0.8 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccc2nc(N3CCCC3)nn2c1 CHEMBL3939485 IC50 0.8 nM
Cc1ncc(C)n2nc(C#Cc3nc(N4CCCC4)nn3C)nc12 CHEMBL3956788 IC50 0.8 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCN(C)CC4)c4ccccc4n3)c(C)c12 CHEMBL3937047 IC50 0.8 nM
CCn1ncc2c1CN(c1ncnn3c(C)nc(-c4ccccc4F)c13)CC2 CHEMBL3639944 IC50 0.801 nM
CC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3691476 IC50 0.803 nM
Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)cn1 CHEMBL4109942 Ki 0.806 nM
Cn1c(CCCOc2cn(CC3CC3)nc(-c3ccnn3-c3ccccc3)c2=O)nc2ccccc21 CHEMBL3814601 IC50 0.81 nM
Cc1ncc(C)n2nc(CCc3cn4c(n3)-c3ccccc3CC4)nc12 CHEMBL3659083 IC50 0.81 nM
CCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C)n1 CHEMBL3955116 Ki 0.81 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c([C@H]2CCOC2)c1 CHEMBL3690319 IC50 0.814 nM
Cc1cc(-c2cc(Cl)cnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)ccn1 CHEMBL3694486 IC50 0.814 nM
Cc1nc2c(nc1-c1cc3nc(N4CCCC4)cc(NCC(C)(C)O)n3n1)CCCO2 CHEMBL3695929 IC50 0.82 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C#Cc3ccc4ncccc4n3)nc(C)n2)cc1OC CHEMBL3967410 Ki 0.82 nM
CCCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3950748 IC50 0.82 nM
COc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2cc(C)cn2)n1 CHEMBL3920174 Ki 0.82 nM
COCCn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)ccc1=O CHEMBL4111775 Ki 0.821 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C(C)C)c2)nc1 CHEMBL4107523 Ki 0.823 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C(C)C)c2)nc1 CHEMBL4109559 Ki 0.827 nM
CC(C)Oc1cccc2c1C(=O)N(CCc1nc3ccccc3c(=O)n1-c1ccc(OCc3ccccc3)cc1)C2=O CHEMBL3644276 Ki 0.83 nM
O=C(c1ccc(Oc2ncccc2C(=O)N[C@H](CO)Cc2ccccc2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690250 IC50 0.839 nM
COc1cc(NC(=O)N2CCc3nc(-c4ccc(Cl)nc4)nc(OC4CCOC4)c3C2)ccn1 CHEMBL3659655 Ki 0.84 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(OCC3(C)CC3)n2)n1 CHEMBL4109751 Ki 0.84 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3c(C)nn(C)c3C)n12 CHEMBL1916116 IC50 0.85 nM
COc1cc(N2CCOCC2)cc2c1nnc1c(C)nc(-c3ccccc3Cl)n12 CHEMBL2070655 IC50 0.85 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(F)(F)C4)c4ccccc4n3)c(C)c12 CHEMBL3945070 IC50 0.85 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(C)=O)cccc4n3)c(C)c12 CHEMBL3938733 IC50 0.86 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 CHEMBL3741492 IC50 0.87 nM
COc1ccc(C(=O)c2ncnc3cc(OC)c(OCCNc4nc5ccccc5s4)cc23)cc1 CHEMBL4456564 IC50 0.87 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3cccnc23)cn1 CHEMBL5422709 Ki 0.87 nM
Cc1nc(C2CCOCC2)c2c(N3CCc4c(c(C(C)C)nn4C)C3)ncnn12 CHEMBL3691390 IC50 0.876 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(C(C)(C)O)n2)n1 CHEMBL4112619 Ki 0.88 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(C#Cc3nc(N4CCCC4)nn3C)nn12 CHEMBL3936487 IC50 0.88 nM
Cc1nc2ccccc2nc1/C=C/c1nc(OC2CCOCC2)cc(N2CCCC2)n1 CHEMBL2180440 IC50 0.89 nM
CO[C@H]1CC[C@H](Nc2cc(N3CCCC3)nc3cc(-c4nc5c(nc4C)OCCC5)nn23)CC1 CHEMBL3695930 IC50 0.89 nM
Cc1c(Cl)cc(C(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3970822 IC50 0.89 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3cc(CO)c4ccccc4n3)sc12 CHEMBL3935706 IC50 0.89 nM
COC1CN(C(=O)c2cccc3nc(NC(=O)c4sc5c(C(C)=O)ccc(CO)c5c4C)ccc23)C1 CHEMBL3913649 IC50 0.89 nM
COc1ccc2c(n1)CCN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)C2 CHEMBL3691396 IC50 0.891 nM
C[C@@]1(O)CC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3694439 IC50 0.897 nM
CC(C)Oc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)Nc1cnn(C)c1)CC2 CHEMBL2180421 Ki 0.9 nM
Cc1nc(C)c(-c2nc(C)c3sc4cc(OCc5ccc6ccccc6n5)ccc4n23)s1 CHEMBL3094144 IC50 0.9 nM
CN(C)C(=O)c1c(F)cccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690036 IC50 0.9 nM
COC[C@H](C)Oc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL3935319 Ki 0.9 nM
CN(C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(-c3ccccc3)nn2c1)C1CC1 CHEMBL3948962 IC50 0.9 nM
Cc1ccc(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)nc1 CHEMBL3979842 Ki 0.9 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(C(C)O)c4ccccc4n3)c(C)c12 CHEMBL3949233 IC50 0.9 nM
COc1ccncc1-c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 CHEMBL3694477 IC50 0.902 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1 CHEMBL4110487 Ki 0.905 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(C)=O)cccc4n3)c(C)c12 CHEMBL3983206 IC50 0.91 nM
Cc1nnc(CN(C)c2cc(OC[C@H]3C[C@@H]3c3ccc4ccccc4n3)nn(C)c2=O)s1 CHEMBL4108412 Ki 0.911 nM
COCCOc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)c1cnn3ccccc13)CC2 CHEMBL2180423 Ki 0.92 nM
COC[C@H](C)Oc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)Nc1ccc(C)nc1)CC2 CHEMBL3659649 Ki 0.92 nM
Cc1c(C(=O)Nc2cc(C(C)(C)O)c3ccccc3n2)sc2c(C(=O)C3CC3)cccc12 CHEMBL3954687 IC50 0.92 nM
CCc1c(C(=O)Nc2cc(CN3CC[C@@H](O)C3)c3ccccc3n2)sc2c(C(C)=O)ccc(COC)c12 CHEMBL4108423 IC50 0.92 nM
CC(=O)N1CC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3694445 IC50 0.926 nM
CCc1ccc(C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc12 CHEMBL3703556 IC50 0.93 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)c(C)c2C)n1 CHEMBL3947591 Ki 0.93 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(C3CC3)c(=O)c2)nc1 CHEMBL4108133 Ki 0.935 nM
COc1cn(-c2ccc(N3CCOC3=O)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL3629540 IC50 0.94 nM
COCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C(F)(F)F)n1 CHEMBL3934680 Ki 0.94 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN(C)CCO)c4ccccc4n3)c(C)c12 CHEMBL3912474 IC50 0.94 nM
OCC1CCN(c2ccccc2Oc2ccc(Nc3nc4ccccc4[nH]3)cc2)CC1 CHEMBL2206213 IC50 0.941 nM
Cn1c(C(=O)c2ccc(Oc3ncccc3C3CCOCC3)cc2)nc2cc(F)ccc21 CHEMBL3694488 IC50 0.943 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CCC#N)c(=O)c2)nc1 CHEMBL4109907 Ki 0.944 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C)c2)nc1 CHEMBL4111295 Ki 0.946 nM
COCC(=O)N1CCC(c2cccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)CC1 CHEMBL3647637 IC50 0.948 nM
COc1cccc2c1C(=O)N(CCc1nc3ccccc3c(=O)n1-c1ccc3cnn([11CH3])c3c1)C2=O CHEMBL2180401 Ki 0.95 nM
COc1cccc2c1C(=O)N(CCc1nc3ccccc3c(=O)n1-c1ccc3cnn(C)c3c1)C2=O CHEMBL2221287 Ki 0.95 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c(N2CCOCC2)c1 CHEMBL2180805 IC50 0.96 nM
CCc1nc(C)nn1-c1cc([C@H]2C[C@@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL3923133 Ki 0.96 nM
Cc1ncc(C)n2nc(CCc3c[nH]c(-c4ccco4)n3)nc12 CHEMBL3681992 IC50 0.97 nM
Cc1nc(C2CC2)nc2c1CN(c1ncnn3c(C)nc(-c4ccccc4F)c13)CC2 CHEMBL3691409 IC50 0.98 nM
Cc1cnc(COc2ccc(-c3nn(CCF)cc3-c3ccncc3)cc2)c(C)c1 CHEMBL1915725 IC50 0.98 nM
Cc1c(Cl)ccc2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3955396 IC50 0.98 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CC3CC3)c2)nc1 CHEMBL4108660 Ki 0.983 nM
COc1cc(-c2ccncc2)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 CHEMBL3741207 IC50 0.99 nM
COCCOc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)c1ncn3ccccc13)CC2 CHEMBL2204538 Ki 0.99 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CCC[C@@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690320 IC50 0.99 nM
Oc1cccc(-c2nc3ccccc3nc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687100 IC50 0.99 nM
Cc1cccn2nc(CCc3nc(-c4cccs4)c[nH]3)nc12 CHEMBL3668916 IC50 0.99 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NC3(C(=O)O)CC3)c2C#N)cc1 CHEMBL247364 IC50 1.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOCC3)c2c1 CHEMBL1939914 Ki 1.0 nM
COCCOc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1 CHEMBL1940057 Ki 1.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(N3CCC(N)CC3)c2c1 CHEMBL1939794 Ki 1.0 nM
Cc1cc(Cl)cc2c(C(O)c3ccnc(F)c3)c3c(C)n[nH]c3nc12 CHEMBL1950088 Ki 1.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(C(=O)c3ccncc3)c2c1 CHEMBL1950083 Ki 1.0 nM
N#Cc1c(-c2ccc(-c3ccccc3OC(F)(F)F)cc2)nc2ccncc2c1O CHEMBL1957366 IC50 1.0 nM
Cc1nccc(-c2ccc(-c3nc4ccncc4c(O)c3C#N)cc2)c1Cl CHEMBL1957460 IC50 1.0 nM
O=c1ccn(-c2ccc(OCC(F)(F)F)cc2)nc1-c1ccnn1-c1ccnc2ccccc12 CHEMBL2180790 IC50 1.0 nM
Cc1ncc(C)n2nc(CCc3cn(C)c(-c4cccs4)n3)nc12 CHEMBL2180418 IC50 1.0 nM
CC(C)Oc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)N(C)c1cn[nH]c1)CC2 CHEMBL2204539 Ki 1.0 nM
COc1cc2nncc(N3CC(O)CC(c4ccccc4)C3)c2cc1OC CHEMBL3601557 IC50 1.0 nM
CCOc1cccc2c1C(=O)N(CCc1nc3ccccc3c(=O)n1-c1ccc(OC)cc1)C2=O CHEMBL3627840 Ki 1.0 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4cnn(C5CC5)c4C3)ncnn12 CHEMBL3695536 IC50 1.0 nM
COc1nc(C2CC2)nc2c1CN(c1ncnn3c(C)nc(-c4ccccc4F)c13)CC2 CHEMBL3695518 IC50 1.0 nM
CN(C)CCn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3639410 IC50 1.0 nM
O=C(Nc1cc(-c2ccccn2)nn1C1CCCCC1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642186 IC50 1.0 nM
O=C(Nc1cc(-c2ccccn2)nn1C1CCOCC1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642192 IC50 1.0 nM
O=C(Nc1cc(-c2cccc(Cl)n2)nn1CCO)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642196 IC50 1.0 nM
CC(C)Cn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642200 IC50 1.0 nM
O=C(Nc1cc(-c2ccccn2)nn1CC1CCCC1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642203 IC50 1.0 nM
O=C(Nc1cc(-c2ccccn2)nn1CC1CCCCC1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642204 IC50 1.0 nM
CCc1ccc(Nc2cncnc2)c(C(=O)Nc2cc(-c3ccccn3)nn2CCO)n1 CHEMBL3642206 IC50 1.0 nM
O=C(Nc1ccc(-c2ccccn2)s1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642219 IC50 1.0 nM
CNC(=O)c1cc(OCCOC)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689946 IC50 1.0 nM
O=C(Nc1cc(F)ccc1C(=O)N1CCC1)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690030 IC50 1.0 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OC5CCC5)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3644269 Ki 1.0 nM
c1cncc(C2CCN(c3nccnc3C3CN(c4ccc5ccccc5n4)C3)C2)c1 CHEMBL3686990 IC50 1.0 nM
Cc1noc(C2CCN(c3nccnc3C3CN(c4ccc5ccccc5n4)C3)C2)n1 CHEMBL3686998 IC50 1.0 nM
c1ccc2nc(N3CC(c4nccnc4N4CCC(c5ccncc5)C4)C3)ccc2c1 CHEMBL3687000 IC50 1.0 nM
CC(C)(C)OC(=O)N1C[C@@H]2CN(c3nccnc3C3CN(c4ccc5ccccc5n4)C3)C[C@@H]2C1 CHEMBL3687002 IC50 1.0 nM
CCOC(=O)NC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687052 IC50 1.0 nM
Cc1nc(NCc2nnc(C)s2)cc(OC[C@H]2C[C@@H]2c2ccc(-c3cccnc3)cn2)n1 CHEMBL3659073 Ki 1.0 nM
Cc1ccc(C)n2nc(CCc3nc(-c4cccs4)cn3C)nc12 CHEMBL3668973 IC50 1.0 nM
O=C(O)CNc1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3977862 IC50 1.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3976547 IC50 1.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3975489 IC50 1.0 nM
c1ccc2nc(CCc3nc4c(N5CCOCC5)ccnn4c3-c3ccc(-c4nnn[nH]4)nc3)ccc2c1 CHEMBL3901162 IC50 1.0 nM
Oc1nc(-c2ccc(-c3c(CCc4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cn2)no1 CHEMBL3972556 IC50 1.0 nM
O=C(O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3894953 IC50 1.0 nM
CC(=O)NS(=O)(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3910507 IC50 1.0 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)s1 CHEMBL3934169 IC50 1.0 nM
O=C(O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1O CHEMBL3964995 IC50 1.0 nM
Oc1c(F)cc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1F CHEMBL3919552 IC50 1.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3955596 IC50 1.0 nM
O=C(O)c1ccc(-c2c(C#Cc3nc4ccccc4s3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3910489 IC50 1.0 nM
O=C(O)c1cccc2nc(/C=C/c3cn4nccc(N5CCOCC5)c4n3)ccc12 CHEMBL3948002 IC50 1.0 nM
O=C(O)c1ccc(-c2c(CSc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3903434 IC50 1.0 nM
O=C(O)c1ccc(Nc2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)c(F)c1 CHEMBL3944823 IC50 1.0 nM
O=C(O)c1cc2ccccc2nc1/C=C/c1cn2nc(Cl)cc(N3CCOCC3)c2n1 CHEMBL3901165 IC50 1.0 nM
N#Cc1ccc(-c2c(/C=C/c3ccc4c(C(=O)O)cccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3984507 IC50 1.0 nM
COc1cccc(-c2c(/C=C/c3ccc4c(C(=O)O)cccc4n3)nc3c(N4CCOCC4)ccnn23)c1 CHEMBL3961195 IC50 1.0 nM
O=C(O)c1ccc(-c2c([C@H]3C[C@H](c4ccc5ccccc5n4)C3)nc3c(N4CCOCC4)cc(Cl)nn23)cc1 CHEMBL3942206 IC50 1.0 nM
O=C(O)[C@@H]1C[C@@H]1c1ccc(-c2c([C@H]3C[C@H](c4ccc5ccccc5n4)C3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3962865 IC50 1.0 nM
CC(C)(CC(=O)O)c1ccc(-c2c([C@H]3C[C@H](c4ccc5ccccc5n4)C3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3900564 IC50 1.0 nM
O=C(O)CC1(c2ccc(-c3c([C@H]4C[C@H](c5ccc6ccccc6n5)C4)nc4c(N5CCOCC5)ccnn34)cc2)COC1 CHEMBL4109003 IC50 1.0 nM
CN(C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(N3CCCC3)nn2c1)C1CC1 CHEMBL3950896 IC50 1.0 nM
O=C(O)Cn1cc(-c2cnc(N3CCOCC3)c3nc(C#Cc4ccc5ccccc5n4)cn23)cn1 CHEMBL3941679 IC50 1.0 nM
COCCOCCOc1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1 CHEMBL3896923 IC50 1.0 nM
O=C1NS(=O)(=O)c2cccc(-c3cnc(N4CCOCC4)c4nc(/C=C/c5ccc6ccccc6n5)cn34)c21 CHEMBL3911138 IC50 1.0 nM
O=C1NS(=O)(=O)c2cc(-c3cnc(N4CCOCC4)c4nc(CCc5ccc6ccccc6n5)cn34)ccc21 CHEMBL3920926 IC50 1.0 nM
O=c1[nH]c(-c2ccc(-c3cnc(N4CCOCC4)c4nc(CCc5ccc6ccccc6n5)cn34)cn2)no1 CHEMBL3956839 IC50 1.0 nM
c1ccc2nc(CCc3cn4c(-c5ccc(-c6nnn[nH]6)nc5)cnc(N5CCOCC5)c4n3)ccc2c1 CHEMBL3973554 IC50 1.0 nM
CS(=O)(=O)Nc1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cn1 CHEMBL3934757 IC50 1.0 nM
CS(=O)(=O)Nc1ccc(-c2cnc(N3CCOCC3)c3nc(COc4ccc5ccccc5n4)cn23)cn1 CHEMBL3980506 IC50 1.0 nM
NS(=O)(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(COc4ccc5ccccc5n4)cn23)cc1 CHEMBL3955838 IC50 1.0 nM
c1ccc2nc(OCc3cn4c(-c5ccc(-c6nnn[nH]6)nc5)cnc(N5CCOCC5)c4n3)ccc2c1 CHEMBL3975222 IC50 1.0 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C[C@@H](C)O)n1 CHEMBL4114851 Ki 1.0 nM
Cc1ccc(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)nc1 CHEMBL3982900 Ki 1.0 nM
Cc1c(C(=O)Nc2cc(C(C)(C)O)c3ccccc3n2)sc2c(C(=O)C(C)(C)C)cccc12 CHEMBL3915791 IC50 1.0 nM
Cc1cnc2c(c1)nc(CCN1C(=O)c3cccc4cccc(c34)C1=O)n2-c1ccccc1 CHEMBL4459590 IC50 1.0 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)[nH]cc2C)nc1 CHEMBL4113323 Ki 1.007 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CCO)c(=O)c2)nc1 CHEMBL4113813 Ki 1.007 nM
O=C1C=C(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690281 IC50 1.01 nM
CN1CC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1=O CHEMBL3690329 IC50 1.01 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C)c2)nc1 CHEMBL4107626 Ki 1.01 nM
Cc1c(Cl)cc(Br)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3953643 IC50 1.01 nM
CCn1ncc2c1CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3695545 IC50 1.02 nM
Clc1ccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)cn1 CHEMBL3690216 IC50 1.04 nM
O[C@@H]1CCC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690296 IC50 1.04 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ncccc4n3)cc2)n1 CHEMBL3920624 IC50 1.05 nM
CC(=O)N1CCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4n3C)cc2)CC1 CHEMBL3694446 IC50 1.06 nM
CSc1cncc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)c1 CHEMBL3694467 IC50 1.06 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CC#N)c(=O)c2)nc1 CHEMBL4109765 Ki 1.06 nM
N#CC1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647641 IC50 1.07 nM
CCn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)ccc1=O CHEMBL4114925 Ki 1.073 nM
COCCOc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL4111261 Ki 1.08 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(OCCO)n2)n1 CHEMBL4107251 Ki 1.09 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C(F)F)c2)nc1 CHEMBL4108683 Ki 1.098 nM
CCc1cc(-c2cnnc3cc(OC)c(OC)cc23)cnc1NC(C)C CHEMBL1956237 IC50 1.1 nM
c1ccc2[nH]c(Nc3ccc(Oc4nccnc4N4CCOCC4)cc3)nc2c1 CHEMBL2180803 IC50 1.1 nM
Cc1nc(C)c(CNc2nc(CCC#Cc3ccccn3)nc(Cl)c2C)s1 CHEMBL3747006 Ki 1.1 nM
Cc1nc(C)c(CNc2nc(OCCCc3ccccn3)nc(Cl)c2C)s1 CHEMBL3746826 Ki 1.1 nM
CCc1cnc(C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc12 CHEMBL3703570 IC50 1.1 nM
O=C(NC1CCC1)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685484 IC50 1.1 nM
CC(C)(O)CNC(=O)c1ncncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685520 IC50 1.1 nM
CC(C)(O)CNC(=O)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685528 IC50 1.1 nM
COCC(C)(C)CNC(=O)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685537 IC50 1.1 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCC(C)(C)CO CHEMBL3685562 IC50 1.1 nM
CC(C)c1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)c1 CHEMBL3685622 IC50 1.1 nM
CC(C)(O)CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1CC1CCO1 CHEMBL3690012 IC50 1.1 nM
O=C(Nc1cccc(F)c1C(=O)N1CCC1)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690037 IC50 1.1 nM
CC(C)(O)CNC(=O)c1c(F)cc(F)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690052 IC50 1.1 nM
CC(C)(O)CNC(=O)c1ncccc1NC(=O)c1nc(C(C)(C)C)ncc1Nc1cncnc1 CHEMBL3690058 IC50 1.1 nM
CCCc1[nH]c(=O)c(Cc2cc3cc4c(cc3nc2NC)OCO4)c2cc(OC)c(OC)cc12 CHEMBL3643881 IC50 1.1 nM
Cc1ncc(C)n2nc(CCc3cn(C)c(-c4ccco4)n3)nc12 CHEMBL3681983 IC50 1.1 nM
Cc1nc(C)c(CNc2cc(C(=O)NCCc3ccccn3)nc3ccnn23)s1 CHEMBL3695726 Ki 1.1 nM
Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc(CF)n2)s1 CHEMBL3659068 Ki 1.1 nM
Cc1nc(NCc2cc(C)on2)cc(OC[C@H]2C[C@@H]2c2ccccn2)n1 CHEMBL3659075 Ki 1.1 nM
COc1ccc(C)n2nc(CCc3nc(-c4cccs4)c[nH]3)nc12 CHEMBL3668972 IC50 1.1 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C2CCOCC2)n1 CHEMBL4107952 Ki 1.1 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(OCC3CC3)n2)n1 CHEMBL3970392 Ki 1.1 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(N3CC(C)(O)C3)n2)n1 CHEMBL4110947 Ki 1.1 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn4ccccc34)c(=O)n(C)n2)nc1 CHEMBL4108629 Ki 1.1 nM
Cc1cn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C3CC3)n2)nn1 CHEMBL3922184 Ki 1.1 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)n1 CHEMBL3986457 Ki 1.1 nM
Cc1nc(-c2ccc(Cl)cn2)cc(N2CC(c3nc4ccccc4n3C)C2)n1 CHEMBL3907759 Ki 1.1 nM
Cc1nc(C2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2[C@@H](C)O)n1 CHEMBL4107014 Ki 1.1 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4ccccc4n3)c(C)c12 CHEMBL3920691 IC50 1.1 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N4CCOCC4)c4ccccc4n3)c(C)c12 CHEMBL3984139 IC50 1.1 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC[C@H](O)C5)cccc4n3)c(C)c12 CHEMBL3910433 IC50 1.1 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)CN)cccc4n3)c(C)c12 CHEMBL3957415 IC50 1.1 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@H](C)N)cccc4n3)c(C)c12 CHEMBL3928656 IC50 1.1 nM
CCn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)ccc1=O CHEMBL4111445 Ki 1.105 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(Cl)cc2)[nH]1 CHEMBL3634746 IC50 1.11 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cc2Cl)nc1 CHEMBL4108003 Ki 1.114 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1 CHEMBL3628995 IC50 1.12 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccccc2)[nH]1 CHEMBL3634744 IC50 1.12 nM
COc1ccc2c(c1)CCN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)C2 CHEMBL3691427 IC50 1.12 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cc2Cl)nc1 CHEMBL4112314 Ki 1.128 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4nc(C5CC5)oc4C3)ncnn12 CHEMBL3695561 IC50 1.14 nM
C[C@]1(O)CCC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690301 IC50 1.14 nM
Cc1cnc(Oc2ccc(C(=O)c3nc4ccccc4n3C)cc2)c(-c2ccnc(C)c2)c1 CHEMBL3694489 IC50 1.14 nM
OCC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687090 IC50 1.14 nM
COc1ccc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4n3C)cc2)c(OC)n1 CHEMBL3694466 IC50 1.15 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1 CHEMBL3628994 IC50 1.16 nM
COc1ncccc1-c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690312 IC50 1.16 nM
OCC1CCN(c2nccnc2C2CN(c3ccc4cc(Cl)ccc4n3)C2)CC1 CHEMBL3691489 IC50 1.16 nM
O=C(c1ccc(Oc2ncccc2-c2cc[nH]c(=O)c2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694463 IC50 1.17 nM
Cc1ccc2nc(N3CC(c4nccnc4N4CCC(CO)CC4)C3)ccc2c1 CHEMBL3691486 IC50 1.17 nM
COc1cc2nncc(-c3cnc(N4CCC(C(C)(C)O)CC4)c(C(F)F)c3)c2cc1OC CHEMBL1956251 IC50 1.2 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(C)c3)c2cc1OC CHEMBL1956235 Kd 1.2 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)cnn1CCOC CHEMBL3685439 IC50 1.2 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1CCOC CHEMBL3685566 IC50 1.2 nM
CCCc1[nH]c(=O)c(Cc2cc3cc4c(cc3nc2NCC)OCO4)c2cc(OC)c(OC)cc12 CHEMBL3643883 IC50 1.2 nM
Cc1ncc(C)n2nc(CCc3cn4c(n3)-c3cccc(F)c3C4)nc12 CHEMBL3659086 IC50 1.2 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OC)c4C3=O)nc3cc(C)ccc3c2=O)cc1 CHEMBL3644261 Ki 1.2 nM
c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686948 IC50 1.2 nM
CCCn1cc(-c2cccs2)nc1CCc1nc2c(OC)ccc(C)n2n1 CHEMBL3668974 IC50 1.2 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(N(C)C)n2)n1 CHEMBL3946887 Ki 1.2 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(N3CCCC3)n2)n1 CHEMBL3982870 Ki 1.2 nM
CCc1nc([C@H]2C[C@@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL3945473 Ki 1.2 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(OCCF)n2)n1 CHEMBL3890395 Ki 1.2 nM
COc1cc2cncc(Cc3cnc4cc(C)ccc4c3)c2cc1OC CHEMBL3930481 IC50 1.2 nM
Cn1ncc(C(=O)N2CCCC2)c1C(=O)Nc1ccc2nc(-c3ccccc3)nn2c1 CHEMBL3904311 IC50 1.2 nM
Cn1ncc(C(=O)N2CCCC2)c1C(=O)Nc1ccc2nc(N3CCCC3)nn2c1 CHEMBL3963198 IC50 1.2 nM
Cc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)c1 CHEMBL3947970 Ki 1.2 nM
Cc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)n1 CHEMBL3941084 Ki 1.2 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2COc2ccccc2)n1 CHEMBL3979544 Ki 1.2 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2-c2ccccc2F)n1 CHEMBL3937405 Ki 1.2 nM
COc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(C)O)n1 CHEMBL3900553 Ki 1.2 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3cc(CN4CC(O)C4)c4ccccc4n3)sc12 CHEMBL3941342 IC50 1.2 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC[C@@H](F)C5)cccc4n3)c(C)c12 CHEMBL4108296 IC50 1.2 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC(OC)C5)cccc4n3)c(C)c12 CHEMBL3911610 IC50 1.2 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(=O)NN5CCCC5)cccc4n3)c(C)c12 CHEMBL3974376 IC50 1.2 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(C(C)C)c(=O)c2)nc1 CHEMBL4107683 Ki 1.203 nM
O[C@H]1CC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690340 IC50 1.21 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C(F)F)c2)nc1 CHEMBL4112882 Ki 1.211 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccncc2)[nH]1 CHEMBL3634847 IC50 1.22 nM
C[C@]1(O)CCCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690322 IC50 1.22 nM
COc1cccc(-c2nccnc2C2CN(c3ccc4ccc(F)cc4n3)C2)c1 CHEMBL3691505 IC50 1.22 nM
Cc1c(Br)cc(Cl)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3979229 IC50 1.22 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C)c(=O)n(C)n2)nc1 CHEMBL4111082 Ki 1.228 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2cccc(F)c2)[nH]1 CHEMBL3634748 IC50 1.23 nM
CC(=O)c1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686974 IC50 1.24 nM
N#CC1CCN(c2cccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647659 IC50 1.25 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(C)c(=O)c2)nc1 CHEMBL4110823 Ki 1.25 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)cn1 CHEMBL4110233 Ki 1.261 nM
COc1ccc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)cn1 CHEMBL3690317 IC50 1.27 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnn(C)c3Cl)c(=O)n(C)n2)nc1 CHEMBL4107685 Ki 1.27 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4c(c(C(F)(F)F)nn4C)C3)ncnn12 CHEMBL3695503 IC50 1.28 nM
COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)cc1 CHEMBL4115288 Ki 1.287 nM
c1cncc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)c1 CHEMBL3690208 IC50 1.29 nM
OC1CC=C(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690315 IC50 1.29 nM
N#Cc1ccc(-c2cccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)cn1 CHEMBL3647626 IC50 1.29 nM
COCC(=O)N1CCC(c2cccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647635 IC50 1.29 nM
Cc1ncc(C)n2nc(CCc3nc(-c4cscn4)cn3C)nc12 CHEMBL3668992 IC50 1.29 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(F)c(=O)n(C)c2)nc1 CHEMBL4111563 Ki 1.294 nM
COc1cc2nncc(-c3cnc(N4CCC(C(C)(C)O)CC4)c(C4CC4)c3)c2cc1OC CHEMBL1956253 IC50 1.3 nM
Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncccc21 CHEMBL3315044 IC50 1.3 nM
NC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3675660 IC50 1.3 nM
Cc1cccc2nc(CCc3nc(-c4ccccc4)cn3CCC3CCCCN3)nn12 CHEMBL3703563 IC50 1.3 nM
CNC(=O)c1ccccc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685455 IC50 1.3 nM
O=C(NC1CCCC1)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685487 IC50 1.3 nM
CNC(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685549 IC50 1.3 nM
CNC(=O)c1cc(C(C)C)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685623 IC50 1.3 nM
Cn1c(C(=O)c2ccc(Oc3ncccc3-c3cc[nH]c(=O)c3)cc2)nc2ccccc21 CHEMBL3694487 IC50 1.3 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OCC5CC5)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3644268 Ki 1.3 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3oc(C)nc3C)n3nccc3n2)nc1 CHEMBL3695716 Ki 1.3 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3CC(C)C)nc2n1 CHEMBL3703544 IC50 1.3 nM
COc1nc([C@H]2C[C@@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL3934608 Ki 1.3 nM
Cc1nc(C)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(OCC3CCO3)n2)n1 CHEMBL4111365 Ki 1.3 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(Cl)c(C)n3)c(=O)n(C)n2)nc1 CHEMBL4110376 Ki 1.3 nM
Cc1cccc([C@H]2C[C@@H]2COc2cc(NCc3cccnc3)c(=O)n(C)n2)n1 CHEMBL4108873 Ki 1.3 nM
Cc1nc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(CC#N)n2)n1 CHEMBL3926635 Ki 1.3 nM
Cc1nc(-c2cccc(C(F)(F)F)n2)cc(N2CC(c3nc4ccccc4n3C)C2)n1 CHEMBL3899933 Ki 1.3 nM
COc1nc(-c2ccc(C)cn2)cc(N2CC(c3nc4ccccc4n3C)C2)n1 CHEMBL3913108 Ki 1.3 nM
Nc1nc(-n2cncn2)nc(NCc2cncs2)c1Br CHEMBL3975310 IC50 1.3 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CCOCC5)cccc4n3)c(C)c12 CHEMBL3965190 IC50 1.3 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4nc(C5CC5)n(C)c(=O)c4C3)ncnn12 CHEMBL3695525 IC50 1.31 nM
CC(=O)N1CCC(c2cccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)CC1 CHEMBL2180769 IC50 1.32 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)nn3CC3CC3)nc12 CHEMBL3947736 IC50 1.32 nM
C[C@@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690284 IC50 1.34 nM
O=C(c1ccc(Oc2ncccc2C2CCOCC2)cc1)c1nc2ncccc2[nH]1 CHEMBL3690347 IC50 1.34 nM
CC(=O)c1cccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)c1 CHEMBL3687062 IC50 1.36 nM
Cc1c(Cl)cc(OCCN2CCOCC2)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3959808 IC50 1.37 nM
COCCn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)ccc1=O CHEMBL4107695 Ki 1.376 nM
Cc1cnc(Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)c(-c2ccnc(C)c2)c1 CHEMBL3694485 IC50 1.38 nM
Cc1nc(C)c(CNc2nc(OCC3CC3c3ccc(C#N)cn3)nc(Cl)c2C)s1 CHEMBL3747617 Ki 1.4 nM
CNC(=O)c1nc(-c2ccccn2)sc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685491 IC50 1.4 nM
CNC(=O)c1c(NC(=O)c2nc(C(C)C)cnc2Nc2cncnc2)cnn1C CHEMBL3685551 IC50 1.4 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1CC1CCCO1 CHEMBL3689975 IC50 1.4 nM
CC(C)(O)CNC(=O)c1cc(F)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690034 IC50 1.4 nM
COc1ccc(C[C@@H](CO)NC(=O)c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)cc1 CHEMBL3690261 IC50 1.4 nM
CCNc1nc2cc(F)c(OC)cc2cc1Cc1c(=O)[nH]c(CC)c2cc(OC)c(OC)cc12 CHEMBL3643901 IC50 1.4 nM
FC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687032 IC50 1.4 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3CCN3CCOCC3)nc2n1 CHEMBL3703547 IC50 1.4 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL4112502 Ki 1.4 nM
COCc1nc(C)nn1-c1cc([C@H]2C[C@@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL3912270 Ki 1.4 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(C(F)(F)F)n2)n1 CHEMBL3902562 Ki 1.4 nM
CCCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3893518 IC50 1.4 nM
Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1 CHEMBL4108799 Ki 1.4 nM
COc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2ncc(C)n2)n1 CHEMBL3983761 Ki 1.4 nM
Cc1nc(C2CC2)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)n1 CHEMBL3965563 Ki 1.4 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCC4)nn3C)nc12 CHEMBL3907097 IC50 1.4 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2F)[nH]1 CHEMBL3634749 IC50 1.41 nM
COc1cnc2c(c1)CN(c1ncnn3c(C)nc(-c4ccccc4F)c13)CC2 CHEMBL3691394 IC50 1.41 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4ncccc4C3)ncnn12 CHEMBL3691416 IC50 1.42 nM
C[C@]1(O)CC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690325 IC50 1.42 nM
CCn1ccc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)cc1=O CHEMBL4113016 Ki 1.429 nM
COc1ccc2nc(C)c3c(C)nc(CC(C)C)n3c2n1 CHEMBL1085406 IC50 1.43 nM
Fc1cnc(O[C@H]2C[C@@H](Nc3nc4ccc(F)cc4s3)C2)c(C2CCOCC2)c1 CHEMBL3647610 IC50 1.44 nM
Cc1cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn2c1C CHEMBL3916270 IC50 1.45 nM
COCCn1c(C)c(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)ccc1=O CHEMBL4112835 Ki 1.461 nM
COc1cc(OC)c2nnc3c(C)nc(-c4cccnc4C)n3c2c1 CHEMBL2070651 IC50 1.48 nM
COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2070666 IC50 1.48 nM
CC(C)(CNC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1)c1ccccn1 CHEMBL3690251 IC50 1.48 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CC[C@@](O)(C(F)(F)F)CC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690351 IC50 1.49 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3sc(C)nc3C)n12 CHEMBL1916115 IC50 1.5 nM
COc1cc(F)c2nc(C)c3c(C)nc(-c4cccnc4C)n3c2c1 CHEMBL1916135 IC50 1.5 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(C4CC4)c3)c2cc1OC CHEMBL1956238 IC50 1.5 nM
COc1cc2c(cc1OC)-c1c(-c3cnc(C(=O)N4CCCOCC4)s3)ncn1CC2 CHEMBL2017060 Ki 1.5 nM
O=C(NCC1CCCO1)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685524 IC50 1.5 nM
CC(CO)CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C CHEMBL3685567 IC50 1.5 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(C)ccc3nc2NCC)c2cc(OC)c(OC)cc12 CHEMBL3643855 IC50 1.5 nM
CCCNc1nc2ccc(OC)cc2cc1Cc1c(=O)[nH]c(CCC)c2cc(OC)c(OC)cc12 CHEMBL3643871 IC50 1.5 nM
CCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 CHEMBL3643888 IC50 1.5 nM
c1cnc(O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)c(C2CCOCC2)c1 CHEMBL3647663 IC50 1.5 nM
N#CC1CCN(c2nccnc2C2CN(c3ncc4ccccc4n3)C2)CC1 CHEMBL3687041 IC50 1.5 nM
COc1ccc(C)n2nc(CCc3nc(-c4cccs4)cn3C)nc12 CHEMBL3668942 IC50 1.5 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(OCC(F)(F)F)n2)n1 CHEMBL3892748 Ki 1.5 nM
Cn1ncc(C(=O)N2CC(F)C2)c1C(=O)Nc1ccc2nc(-c3ccccc3)nn2c1 CHEMBL3947734 IC50 1.5 nM
Cn1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccnn3C)c(=O)n(C)n2)n1 CHEMBL4106936 Ki 1.5 nM
COCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C)n1 CHEMBL3925703 Ki 1.5 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3cc(CN4CCC(O)C4)c4ccccc4n3)sc12 CHEMBL3929600 IC50 1.5 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3919436 IC50 1.5 nM
COc1cc2nncc(-c3cnc(N4CCC(O)(c5cccnc5)CC4)c(C)c3)c2cc1OC CHEMBL3393194 IC50 1.52 nM
c1cnc(O[C@H]2C[C@@H](Nc3nc4ccccc4[nH]3)C2)c(C2CCOCC2)c1 CHEMBL3647599 IC50 1.529 nM
COc1cc(N2CCOCC2)cc2c1nnc1c(C)nc(-c3ccccc3C)n12 CHEMBL2070654 IC50 1.53 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3c(C)nn(C)c3Cl)c(=O)n(C)n2)nc1 CHEMBL4110661 Ki 1.53 nM
O=C(c1ccc(Oc2ncccc2-c2ccnc(F)c2)cc1)c1nc2ccc(F)cc2[nH]1 CHEMBL3694480 IC50 1.54 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(F)c(=O)n(C)c2)nc1 CHEMBL4115464 Ki 1.547 nM
CC(=O)N1CC=C(c2cncnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3694428 IC50 1.56 nM
Nc1ccc(-c2nc3ccccc3nc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3687099 IC50 1.56 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C)n(C)c(=O)c2)nc1 CHEMBL4113314 Ki 1.562 nM
COc1cc(-c2ccnc(F)c2)cc2c1nc(C)c1c(C)nc(-c3ccnc(F)c3)n12 CHEMBL3741064 IC50 1.57 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3c(C)nn(C)c3Cl)c(=O)n(C)n2)nc1 CHEMBL4107185 Ki 1.58 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)n(C4CC4)n3)nn12 CHEMBL3942308 IC50 1.58 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CCC#N)c(=O)c2)nc1 CHEMBL4110688 Ki 1.585 nM
O=C(c1ccc(Oc2ncccc2N2CCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690204 IC50 1.59 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CC[C@](O)(C(F)(F)F)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690361 IC50 1.59 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(CO)c3)c2cc1OC CHEMBL1956245 IC50 1.6 nM
COC(C)(C)CNC(=O)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685536 IC50 1.6 nM
CC(C)(O)CNC(=O)c1cc(Cl)ncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689991 IC50 1.6 nM
CCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 CHEMBL3643859 IC50 1.6 nM
CCCc1[nH]c(=O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12 CHEMBL3643903 IC50 1.6 nM
Cc1ccc(C)n2nc(CCc3c[nH]c(-c4nccs4)n3)nc12 CHEMBL3681988 IC50 1.6 nM
Cc1cccc2nc(CCc3nc(-c4ccccc4)cn3CC(C)C)nn12 CHEMBL3703534 IC50 1.6 nM
Cc1nc(C)c(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc(C3CC3)n2)s1 CHEMBL3659069 Ki 1.6 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(N)nc(NCc3nnc(C)s3)c2C#N)nc1 CHEMBL3659077 Ki 1.6 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(C(N)=O)n2)n1 CHEMBL3971216 Ki 1.6 nM
COc1cc2cncc(Cc3ccc4oc(-c5ccc(C(=O)O)cc5)nc4c3)c2cc1OC CHEMBL3906159 IC50 1.6 nM
Nc1nc(-n2ncc3ccccc32)nc(NCc2cncs2)c1Br CHEMBL3958730 IC50 1.6 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(C(C)(C)O)c4ccccc4n3)c(C)c12 CHEMBL3901356 IC50 1.6 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3ccc4ccccc4n3)sc12 CHEMBL3966724 IC50 1.6 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N4CCN(C)CC4)c4ccccc4n3)c(C)c12 CHEMBL3958918 IC50 1.6 nM
CCOCc1cccc2nc(NC(=O)c3sc4c(C(C)=O)ccc(COC)c4c3C)ccc12 CHEMBL3890078 IC50 1.6 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C)cccc4n3)c(C)c12 CHEMBL3981670 IC50 1.6 nM
COc1cc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)ccn1 CHEMBL3690203 IC50 1.61 nM
CC(=O)N1CCC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3694427 IC50 1.61 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1 CHEMBL3634745 IC50 1.62 nM
Cc1nc2c(c(=O)n1C)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3695512 IC50 1.62 nM
C[C@@]1(O)CCC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690321 IC50 1.62 nM
C[C@]1(O)CC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690324 IC50 1.63 nM
O[C@H]1CC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690345 IC50 1.63 nM
O=C(c1ccc(Oc2ncccc2-c2ccnc(Cl)c2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694434 IC50 1.63 nM
COC[C@H](Cc1ccccc1)NC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690272 IC50 1.64 nM
COc1cc(F)cc2c1nnc1c(C)nc(-c3sccc3C)n12 CHEMBL2070664 IC50 1.65 nM
C1=C(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CCNC1 CHEMBL3690260 IC50 1.68 nM
COc1cc(C#N)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741518 IC50 1.69 nM
COc1cc(N2CCOCC2)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n12 CHEMBL1916126 IC50 1.7 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(C(=O)O)c2C)cc1 CHEMBL2335121 IC50 1.7 nM
CN1CCN(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1=O CHEMBL3086098 IC50 1.7 nM
CNC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4cc(F)ccc4n3)C2)cc1F CHEMBL3675656 IC50 1.7 nM
Cc1nc(C)c(CNc2nc(CC[C@H]3C[C@@H]3c3ccccn3)nc(Cl)c2C)s1 CHEMBL3747736 Ki 1.7 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCC(F)F CHEMBL3685565 IC50 1.7 nM
CNC(=O)COc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NC)c1 CHEMBL3690050 IC50 1.7 nM
COc1ccc(Cn2c(Nc3ccc(Oc4ncccc4C4CCOCC4)cc3)nc3ccccc32)cc1 CHEMBL3694456 IC50 1.7 nM
COc1ccccc1-c1cn(C)c(CCNC(=O)c2c(C(=O)N3CCC3)cnn2C)n1 CHEMBL3649550 IC50 1.7 nM
COc1ccc(C)n2nc(CCc3nc(-c4cccs4)cn3CCCC#N)nc12 CHEMBL3668976 IC50 1.7 nM
COc1ccc(C)n2nc(CCc3nc(-c4ccsc4)cn3C)nc12 CHEMBL3668978 IC50 1.7 nM
Cc1nc(C2CC2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C(C)C)n1 CHEMBL3911911 Ki 1.7 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(NC(C)(C)C)n2)n1 CHEMBL3974865 Ki 1.7 nM
Cc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)n1 CHEMBL3978899 Ki 1.7 nM
COc1cc2ncnc(N3CCOCC3)c2cc1OCCNc1nc2ccccc2s1 CHEMBL4437555 IC50 1.7 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cncnc3)c(=O)n(C)n2)nc1 CHEMBL4112211 Ki 1.704 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CCC[C@H](O)C2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694449 IC50 1.71 nM
Cn1ccc2nc(COc3ccc(-c4ccc(=O)[nH]c4-c4ccc(F)cc4)cc3)ccc21 CHEMBL3634857 IC50 1.73 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(C)c(=O)c2)nc1 CHEMBL4109895 Ki 1.734 nM
O=C(c1ccc(Oc2ncccc2C(=O)NCCc2ccccn2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690228 IC50 1.74 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CCC#N)c2)nc1 CHEMBL4113319 Ki 1.777 nM
COc1ccc2nc(COc3ccc(-c4c(-c5ccncc5)cnn4C)cc3)ccc2c1 CHEMBL3222276 IC50 1.78 nM
Cc1cc2c(cn1)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3695543 IC50 1.78 nM
Cc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687080 IC50 1.78 nM
CCn1c(C)c(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)ccc1=O CHEMBL4109007 Ki 1.783 nM
CCn1cc(-c2ccccc2)nc1C1CC1c1nc2c(C)ncc(C)n2n1 CHEMBL3648443 IC50 1.79 nM
COc1ccnc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4n3C)cc2)c1 CHEMBL3694482 IC50 1.79 nM
COc1ccc2nc(C)c3c(C)nc(-c4cccc(C(N)=O)c4)n3c2n1 CHEMBL1915896 IC50 1.8 nM
COc1cc2nncc(-c3cnc(N4CCC(O)(C5CC5)CC4)c(C)c3)c2cc1OC CHEMBL1956248 IC50 1.8 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(-c5nccs5)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3627843 Ki 1.8 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(CCCF)c4ccccc4n3)cc2)n1 CHEMBL3628715 IC50 1.8 nM
Cn1cc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)n1 CHEMBL3685518 IC50 1.8 nM
CNC(=O)c1cc(Cl)ncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689990 IC50 1.8 nM
CNC(=O)c1ccc(F)c(F)c1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690055 IC50 1.8 nM
CCNc1nc2ccc(OC)cc2cc1Cc1c(=O)[nH]c(COC)c2cc(OC)c(OC)cc12 CHEMBL3643886 IC50 1.8 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OCC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 CHEMBL3643907 IC50 1.8 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(-c5ncco5)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3644275 Ki 1.8 nM
Cc1ncc(C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc12 CHEMBL2180414 IC50 1.8 nM
COC(=O)c1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3895138 Ki 1.8 nM
COc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C2CC2)n1 CHEMBL3911279 Ki 1.8 nM
Cc1nc(C2CCOCC2)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)n1 CHEMBL3963280 Ki 1.8 nM
Cc1nc(-c2ccccn2)cc(N2CC(c3nc4ccccc4n3C)C2)n1 CHEMBL3954234 Ki 1.8 nM
Nc1nc(-n2ncc3ccncc32)nc(NCC2CC2)c1Br CHEMBL3905879 IC50 1.8 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN(C)C)cccc4n3)c(C)c12 CHEMBL3897827 IC50 1.8 nM
COCCOc1cc(N2CCCC2)nc(/C=C/c2nc(C)c(C)c(N(C)C)n2)n1 CHEMBL5284754 IC50 1.8 nM
[2H]C([2H])Oc1cn(-c2ccc(C3CCOCC3)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL5283384 IC50 1.8 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CC(F)F)c(=O)c2)nc1 CHEMBL4110713 Ki 1.81 nM
COc1ccc2nc(COc3ccc(-c4nn(C)cc4-c4ccncc4)cc3)ccc2c1 CHEMBL3218039 IC50 1.82 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(C)c(=O)n(C)n2)nc1 CHEMBL4110795 Ki 1.828 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)oc1-c1cccnc1 CHEMBL3649584 IC50 1.83 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(C(F)F)c(=O)c2)nc1 CHEMBL4109464 Ki 1.834 nM
COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(-c3cccc(F)c3C)n12 CHEMBL2070668 IC50 1.85 nM
Cc1ccc(-c2[nH]c(=O)ccc2-c2ccc(OCc3ccc4ccccc4n3)cc2)cc1 CHEMBL3634751 IC50 1.85 nM
COc1ccc(-c2ccnc(F)c2)c(Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)n1 CHEMBL3694483 IC50 1.86 nM
COc1ncc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)cn1 CHEMBL3690213 IC50 1.87 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)n[nH]3)nc12 CHEMBL3980753 IC50 1.87 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915890 IC50 1.9 nM
Cc1ccccc1-c1nc(C)c2c(C)nc3c(OC(F)F)cc(F)cc3n12 CHEMBL1916118 IC50 1.9 nM
CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccn2cc(-c3ccccc3)nc2n1 CHEMBL2180406 IC50 1.9 nM
COc1ccc(-c2[nH]c(=O)ccc2-c2ccc(OCc3ccc4ccccc4n3)cc2)cc1 CHEMBL3634845 IC50 1.9 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(C2CCCCC2)ncc1Nc1cncnc1 CHEMBL3685507 IC50 1.9 nM
Cc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)N2CCC2)n1 CHEMBL3690007 IC50 1.9 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(C)ccc3nc2NC)c2cc(OC)c(OC)cc12 CHEMBL3643854 IC50 1.9 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(NC(C)C)n2)n1 CHEMBL3922587 Ki 1.9 nM
CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(N3CCCC3)nn2c1 CHEMBL3928593 IC50 1.9 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)cn1 CHEMBL4109032 Ki 1.9 nM
COCCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C)n1 CHEMBL3909129 Ki 1.9 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(C)c3)c2cc1O[11CH3] CHEMBL5288053 IC50 1.9 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(OC)c2)nc1 CHEMBL4113672 Ki 1.901 nM
C[C@@]1(O)CC[C@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)C1 CHEMBL3690365 IC50 1.92 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(C(F)F)c(=O)c2)nc1 CHEMBL4112173 Ki 1.928 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4cnn(CC5CCC5)c4C3)ncnn12 CHEMBL3695553 IC50 1.94 nM
Cc1ncccc1-c1nccnc1O[C@H]1C[C@@H](Nc2nc3ccccc3s2)C1 CHEMBL3647620 IC50 1.94 nM
COc1cc2c(cn1)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691439 IC50 1.95 nM
CCn1c(C)c(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)ccc1=O CHEMBL4107831 Ki 1.952 nM
CCOc1ccccc1-c1ccc(-c2nc3ccccc3c(N[C@H](C)C(=O)O)c2C#N)cc1 CHEMBL248058 IC50 2.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(N[C@@H](Cc3ccccc3)C(=O)O)c2C#N)cc1 CHEMBL395205 IC50 2.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NC(CC(F)(F)F)C(=O)O)c2C#N)cc1 CHEMBL245709 IC50 2.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NCCC(=O)O)c2C#N)cc1 CHEMBL245592 IC50 2.0 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3cnccc3C)n12 CHEMBL1916112 IC50 2.0 nM
Cc1cc(O)cc2c(CN3CCCOCC3)c3c(C)n[nH]c3nc12 CHEMBL1940056 Ki 2.0 nM
COc1ccc(C(C#N)c2c3cc(OC)cc(C)c3nc3[nH]nc(C)c23)cc1 CHEMBL1950081 Ki 2.0 nM
COc1ccc(C(O)c2c3cc(OC)cc(C)c3nc3[nH]nc(C)c23)cc1 CHEMBL1950078 Ki 2.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(C(O)c3cncs3)c2c1 CHEMBL1949942 Ki 2.0 nM
N#CCOc1ccccc1-c1ccc(-c2nc3ccncc3c(O)c2C#N)cc1 CHEMBL1957367 IC50 2.0 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OC)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL2180426 Ki 2.0 nM
O=C(Nc1cnc(-c2ccccn2)s1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL2180800 IC50 2.0 nM
Cc1nc(C)c(CNc2nc(OCCc3ccccn3)nc(Cl)c2C)s1 CHEMBL3622894 Ki 2.0 nM
O=C(Nc1cc(-c2ccccn2)nn1CCO)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642183 IC50 2.0 nM
O=C(Nc1cc(-c2ccccn2)nn1CCN1CCOCC1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642188 IC50 2.0 nM
CCc1ccc(Nc2cncnc2)c(C(=O)Nc2cc(-c3ccccn3)nn2C)n1 CHEMBL3642191 IC50 2.0 nM
O=C(Nc1cc(-c2ccccn2)nn1CC(F)(F)F)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642194 IC50 2.0 nM
CCCn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642195 IC50 2.0 nM
O=C(Nc1cc(-c2ccc(Cl)cn2)nn1CCO)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642198 IC50 2.0 nM
O=C(Nc1cc(-c2ccccn2)nn1Cc1ccccc1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642201 IC50 2.0 nM
Cn1cncc1Cn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642208 IC50 2.0 nM
O=C(NC1CCCCC1)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685503 IC50 2.0 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1CC1CCO1 CHEMBL3690011 IC50 2.0 nM
CCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCCOC)c2cc(OC)c(OC)cc12 CHEMBL3643896 IC50 2.0 nM
COc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686949 IC50 2.0 nM
Fc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686950 IC50 2.0 nM
CCOC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686957 IC50 2.0 nM
COc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccn1 CHEMBL3686958 IC50 2.0 nM
CN(C)c1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686965 IC50 2.0 nM
c1ccc(-c2cccc(-c3nccnc3C3CN(c4ccc5ccccc5n4)C3)c2)cc1 CHEMBL3686967 IC50 2.0 nM
COc1ccccc1-c1nccnc1C1CN(c2ccc3ccccc3n2)C1 CHEMBL3686971 IC50 2.0 nM
CN(C(=O)OC(C)(C)C)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3686994 IC50 2.0 nM
COC(=O)NC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687050 IC50 2.0 nM
CCOC(=O)N(C)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687056 IC50 2.0 nM
NC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3675658 IC50 2.0 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3nc4ccccc4c(=O)n3C)cc2)n1 CHEMBL3930669 IC50 2.0 nM
C(=C/c1nc2c(N3CCOCC3)ccnn2c1-c1ccc(-c2nnn[nH]2)nc1)\c1ccc2ccccc2n1 CHEMBL3946431 IC50 2.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3944218 IC50 2.0 nM
c1ccc2nc(SCc3nc4c(N5CCOCC5)ccnn4c3-c3ccc(-c4nnn[nH]4)nc3)ccc2c1 CHEMBL3892340 IC50 2.0 nM
CC(=O)NS(=O)(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3904950 IC50 2.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3980594 IC50 2.0 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)o1 CHEMBL3972697 IC50 2.0 nM
O=C(O)c1ccc(-c2c(C#Cc3ccccn3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3980574 IC50 2.0 nM
COc1ccc(C#Cc2nc3c(N4CCOCC4)ccnn3c2-c2ccc(C(=O)O)cc2)nc1 CHEMBL3932648 IC50 2.0 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)nc1 CHEMBL3920199 IC50 2.0 nM
O=C(O)CCc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3951727 IC50 2.0 nM
O=C(O)c1cc(/C=C/c2cn3nc(Cl)cc(N4CCOCC4)c3n2)nc2ccccc12 CHEMBL3965547 IC50 2.0 nM
CS(=O)(=O)NC(=O)CCc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3978469 IC50 2.0 nM
O=C(O)c1cccc2nc(/C=C/c3nc4c(N5CCOCC5)cc(Cl)nn4c3-c3cccnc3)ccc12 CHEMBL3916906 IC50 2.0 nM
O=C(O)c1ccc(-c2c(C3CN(c4ccc5ccccc5n4)C3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3964851 IC50 2.0 nM
O=C(O)C1CCN(c2ccc(-c3c([C@H]4C[C@H](c5ccc6ccccc6n5)C4)nc4c(N5CCOCC5)ccnn34)cc2)CC1 CHEMBL3970471 IC50 2.0 nM
O=C(O)CCc1ccc(-c2c([C@H]3C[C@H](c4ccc5ccccc5n4)C3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3902868 IC50 2.0 nM
CC(C)(C(=O)O)c1ccc(-c2c([C@H]3C[C@H](c4ccc5ccccc5n4)C3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3893921 IC50 2.0 nM
O=C(O)C1(c2ccc(-c3c([C@H]4C[C@H](c5ccc6ccccc6n5)C4)nc4c(N5CCOCC5)ccnn34)cc2)CC1 CHEMBL3915570 IC50 2.0 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(Br)nc2C)n1 CHEMBL4111494 Ki 2.0 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(N3CCNCC3)n2)n1 CHEMBL3938983 Ki 2.0 nM
O=C(O)c1cc(/C=C/c2cn3ccnc(N4CCOCC4)c3n2)nc2ccccc12 CHEMBL3983380 IC50 2.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(CSc4ccc5ccccc5n4)cn23)cc1 CHEMBL3948257 IC50 2.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(/C=C/c4ccc5ccccc5n4)cn23)cn1 CHEMBL3957009 IC50 2.0 nM
O=C(O)c1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cn1 CHEMBL3962449 IC50 2.0 nM
O=C(O)CCNC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1 CHEMBL3911309 IC50 2.0 nM
O=C(O)CNc1ccc(-c2cnc(N3CCOCC3)c3nc(/C=C/c4ccc5ccccc5n4)cn23)cn1 CHEMBL3894249 IC50 2.0 nM
c1ccc2nc(SCc3cn4c(-c5ccc(-c6nnn[nH]6)nc5)cnc(N5CCOCC5)c4n3)ccc2c1 CHEMBL3981935 IC50 2.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(COc4ccc5ccccc5n4)cn23)cn1 CHEMBL3909828 IC50 2.0 nM
c1ccc2nc(OCc3cn4c(-c5ccc(-c6nnn[nH]6)cc5)cnc(N5CCOCC5)c4n3)ccc2c1 CHEMBL3942390 IC50 2.0 nM
O=C(O)CNc1ccc(-c2cnc(N3CCOCC3)c3nc(COc4ccc5ccccc5n4)cn23)cn1 CHEMBL3900411 IC50 2.0 nM
Cn1cc(-c2ccccc2)nc1CCn1nc2cccc(-c3ccncc3)n2c1=O CHEMBL3971574 Ki 2.0 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C[C@H](C)O)n1 CHEMBL3927730 Ki 2.0 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C2CCCCC2)n1 CHEMBL3945472 Ki 2.0 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3cc(C(C)O)c4ccccc4n3)sc12 CHEMBL3912247 IC50 2.0 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(F)F)cccc4n3)c(C)c12 CHEMBL3978401 IC50 2.0 nM
Cc1cc(C)n2nc(CCc3cc(O)n4nc5ccccc5c4n3)nc2n1 CHEMBL4470042 IC50 2.0 nM
Cc1cnc(COc2ccc(-c3nn(CC[18F])cc3-c3ccncc3)cc2)c(C)c1 CHEMBL1915749 IC50 2.0 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)nn3C3CC3)nc12 CHEMBL3960934 IC50 2.03 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL2070653 IC50 2.06 nM
O=C(c1ccc(Oc2ncccc2C2(C(F)F)CCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694471 IC50 2.07 nM
O=C(c1ccc(Oc2ncccc2C2CCNCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3694492 IC50 2.07 nM
Cc1c(Cl)cc(OCC(=O)N2CCCOC2)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3976218 IC50 2.07 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(OCC(F)(F)F)c4C3=O)nc3nc(C)ccc3c2=O)cc1 CHEMBL3644270 Ki 2.08 nM
O=C(NC1CC1)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685483 IC50 2.1 nM
CC(C)(O)CNC(=O)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685495 IC50 2.1 nM
CNC(=O)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685546 IC50 2.1 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCC(F)(F)F CHEMBL3685564 IC50 2.1 nM
CNC(=O)c1cc(OCC(C)(C)O)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690066 IC50 2.1 nM
Cc1c(Cl)nc(OCCCc2ccc3ncccc3n2)nc1NCc1cnn(C)c1 CHEMBL3665946 Ki 2.1 nM
CO[C@@H](C)c1nc(C)nn1-c1cc([C@@H]2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL3935322 Ki 2.1 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccn3c2C)cc(-n2nc(C)nc2C)n1 CHEMBL4114485 Ki 2.1 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3893152 Ki 2.1 nM
CO[C@H](C)c1nc(C)nn1-c1cc(C2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL4110017 Ki 2.1 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCOCC4)c4ccccc4n3)c(C)c12 CHEMBL3958357 IC50 2.1 nM
CC(=O)c1ccc(CO)c2c(C)c(C(=O)Nc3ccc4c(CO)cccc4n3)sc12 CHEMBL3938164 IC50 2.1 nM
Cc1ccc2[nH]c(CCN3C(=O)c4cccc5cccc(c45)C3=O)nc2c1 CHEMBL4533958 IC50 2.1 nM
Cc1nc(C2CC2c2nc3ccccn3c2C)cc(-n2nc(C)nc2C)n1 CHEMBL4461114 Ki 2.1 nM
FC1(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CCOCC1 CHEMBL3690289 IC50 2.12 nM
Cc1c(Cl)ccc2nc(CCc3nc(N4CCCC4)n(C)n3)nn12 CHEMBL3946432 IC50 2.13 nM
Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1 CHEMBL4111130 Ki 2.15 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CCC#N)c2)nc1 CHEMBL4115003 Ki 2.151 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cc2C)nc1 CHEMBL4106710 Ki 2.158 nM
Cc1c(C#N)cc(Cl)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3897535 IC50 2.16 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)nc2OC)nc1 CHEMBL4115163 Ki 2.163 nM
O=C(Nc1ccccc1)N1CCc2nc(-c3cccnc3)nc(NCC3C=NC(c4ccccc4)=N3)c2C1 CHEMBL2180429 Ki 2.19 nM
O=C(Nc1ccccc1)N1CCc2nc(-c3cccnc3)nc(NCc3cnc(-c4ccccc4)[nH]3)c2C1 CHEMBL3675614 Ki 2.19 nM
COc1nc2cccnc2n1C1CC(Nc2nc3ccccc3s2)C1 CHEMBL3287905 IC50 2.2 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCC(C)(F)F CHEMBL3685582 IC50 2.2 nM
CON(C)C(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C CHEMBL3690062 IC50 2.2 nM
CCc1[nH]c(=O)c(Cc2cc3cc4c(cc3nc2NC)OCO4)c2cc(OC)c(OC)cc12 CHEMBL3643880 IC50 2.2 nM
Cc1nc(CNc2nc(OC[C@H]3C[C@@H]3c3ccc4ncccc4n3)nc(Cl)c2C)n(C)n1 CHEMBL3665959 Ki 2.2 nM
CN1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1=O CHEMBL3687044 IC50 2.2 nM
CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(-c3ccccc3)nn2c1 CHEMBL3978102 IC50 2.2 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C2CCOCC2)n1 CHEMBL3982758 Ki 2.2 nM
Cc1nc(-c2nccs2)cc(N2CC(c3nc4ccccc4n3C)C2)n1 CHEMBL3979959 Ki 2.2 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3cc(C)c4ccccc4n3)sc12 CHEMBL3959122 IC50 2.2 nM
C1=C(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CCOC1 CHEMBL3690266 IC50 2.21 nM
COc1cccc(-c2nc3ccccc3nc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687101 IC50 2.22 nM
Cc1c(Cl)cc(C#N)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3970462 IC50 2.22 nM
N#CC1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)CC1 CHEMBL3647651 IC50 2.26 nM
OCC1CCN(c2nccnc2C2CN(c3ccc4cccc(F)c4n3)C2)CC1 CHEMBL3691495 IC50 2.28 nM
O=C(c1ccc(Oc2ncccc2C2CCOC2)cc1)c1nc2ccccc2n1CCF CHEMBL3694476 IC50 2.29 nM
CCNC(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689952 IC50 2.3 nM
CC(C)(O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690023 IC50 2.3 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCCOC)c2cc(OC)c(OC)cc12 CHEMBL3643895 IC50 2.3 nM
Cc1ccc(C)n2nc(CCc3nc(-c4nccs4)cn3C)nc12 CHEMBL3668982 IC50 2.3 nM
CCCc1ncc(Cc2ccc3cccc(OCCC(=O)O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3958129 IC50 2.3 nM
CCN(CC)c1nc2ccc(NC(=O)c3c(C(=O)N(C)C4CC4)cnn3C)cn2n1 CHEMBL3904410 IC50 2.3 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3cc(CN(C)C(C)=O)c4ccccc4n3)sc12 CHEMBL3967656 IC50 2.3 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CC(F)F)c2)nc1 CHEMBL4114893 Ki 2.301 nM
C[C@]1(O)CC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3694438 IC50 2.31 nM
N#CC1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647649 IC50 2.31 nM
COc1cccc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)n1 CHEMBL3690357 IC50 2.32 nM
COn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)ccc1=O CHEMBL4112715 Ki 2.334 nM
Cc1nc(C)c2c(n1)CCN(c1ncnn3c(C)nc(-c4ccccc4F)c13)C2 CHEMBL3695514 IC50 2.34 nM
CC(=O)Nc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3691484 IC50 2.36 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(C(F)F)c3)c2cc1OC CHEMBL1956239 IC50 2.4 nM
CC(O)C1CCN(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL2206223 IC50 2.4 nM
OCC1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL2180767 IC50 2.4 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12 CHEMBL3643889 IC50 2.4 nM
CC1=CN(O)C(C)c2nc(CCc3cn4c(n3)-c3ccccc3C4)nn21 CHEMBL3659084 IC50 2.4 nM
Cc1nccn2nc(-c3ccn4c(C)c(-c5ccccc5)nc4c3)nc12 CHEMBL3703193 IC50 2.4 nM
Cc1nc(-c2ccc(C#N)cn2)cc(N2CC(c3nc4ccccc4n3C)C2)n1 CHEMBL3896762 Ki 2.4 nM
COc1cccc2c1nnc1c(C)nc(-c3ccccc3Cl)n12 CHEMBL2070648 IC50 2.41 nM
Cc1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3ncc4ccccc4n3)C2)cn1 CHEMBL3647624 IC50 2.43 nM
OCC1CCN(c2nc3ccccc3nc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687095 IC50 2.43 nM
Fc1cnc(O[C@H]2C[C@@H](Nc3nc4cccc(F)c4s3)C2)c(C2CCOCC2)c1 CHEMBL3647611 IC50 2.45 nM
COc1ccc(CCNC(=O)c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)cc1 CHEMBL3690268 IC50 2.47 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c([C@@H]2CCCOC2)c1 CHEMBL3690328 IC50 2.49 nM
Cc1cn2nccc2nc1-c1cc2nc(N3CCCC3)cc(NCC(C)(C)O)n2n1 CHEMBL3695924 IC50 2.5 nM
Cc1nc2c(nc1-c1cc3nc(N4CCCC4)cc(NC4CCOCC4)n3n1)CCCO2 CHEMBL3695928 IC50 2.5 nM
O=C(NC1CCOC1)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685523 IC50 2.5 nM
CNC(=O)c1c(NC(=O)c2nc(C(C)(C)C)cnc2Nc2cncnc2)cnn1C CHEMBL3685572 IC50 2.5 nM
O=C(Nc1cccnc1C(=O)N1CCCC1)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685614 IC50 2.5 nM
COc1ccc([C@H]2C[C@@H]2COc2nc3cccnc3cc2C2CCCN(C(C)=O)C2)nc1 CHEMBL3699655 Ki 2.5 nM
COc1ccc(C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc12 CHEMBL3703549 IC50 2.5 nM
Cc1nc([C@H]2C[C@@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C2CCCCC2)n1 CHEMBL3978973 Ki 2.5 nM
COc1cc2cncc(Cc3cnc4ccc(OCC(N)=O)cc4c3)c2cc1OC CHEMBL3919257 IC50 2.5 nM
Cn1ncc(C(=O)N2CCOCC2)c1C(=O)Nc1ccc2nc(-c3ccccc3)nn2c1 CHEMBL3973796 IC50 2.5 nM
CCN(CC)c1nc2ccc(NC(=O)c3c(C(=O)N4CCOCC4)cnn3C)cn2n1 CHEMBL3979909 IC50 2.5 nM
O=c1n(CCc2ccc3ccccc3n2)nc2cccc(N3CCOCC3)n12 CHEMBL3968865 Ki 2.5 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2cccn2)n1 CHEMBL3985424 Ki 2.5 nM
COCc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C2CC2)n1 CHEMBL3973158 Ki 2.5 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(O)CC(F)(F)F)n1 CHEMBL3891104 Ki 2.5 nM
Cc1nc([C@@H]2CCOC2)c2c(N3Cc4c(cnn4C)[C@H](C)C3)ncnn12 CHEMBL3691389 IC50 2.51 nM
COc1ccccc1-c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3694460 IC50 2.51 nM
CNC(=O)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3691479 IC50 2.51 nM
Cc1c(OC[C@H]2C[C@@H]2c2ccccn2)nc2ccnn2c1NCc1cnn(C)c1 CHEMBL3695723 Ki 2.52 nM
Cc1nc2c(s1)CN(c1ncnn3c(C)nc([C@H]4CCOC4)c13)CC2 CHEMBL3691392 IC50 2.53 nM
COc1ncccc1-c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 CHEMBL3690337 IC50 2.54 nM
O[C@H]1CC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690341 IC50 2.54 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cnn(CC(F)(F)F)c4C3)ncnn12 CHEMBL3695549 IC50 2.55 nM
OCC1CCN(c2nccnc2C2CN(c3ncc4ccccc4n3)C2)CC1 CHEMBL3687091 IC50 2.56 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CC(F)F)c2)nc1 CHEMBL4112838 Ki 2.563 nM
CC[C@]1(O)CC[C@@H](c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690359 IC50 2.58 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(C(C)(C)O)c3)c2cc1OC CHEMBL1956244 IC50 2.6 nM
COc1cc2nncc(-c3cnc(N4CCC(O)(c5ccccn5)CC4)c(C)c3)c2cc1OC CHEMBL1956246 IC50 2.6 nM
CC(=O)N1CCC(c2nc3ccccc3nc2OC2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3356684 IC50 2.6 nM
Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncc(Cl)cc21 CHEMBL3315046 IC50 2.6 nM
CC(C)OCCNC(=O)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685522 IC50 2.6 nM
O=C(NC1COC1)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685529 IC50 2.6 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3[nH]2)cc(-n2nc(C)nc2C)n1 CHEMBL4114845 Ki 2.6 nM
CCOC(=O)Cc1nc(C)nn1-c1cc(N2CC(c3nc4ccccc4n3C)C2)nc(C)n1 CHEMBL3921094 Ki 2.6 nM
CC(=O)c1ccc(C(C)=O)c2c(C)c(C(=O)Nc3cc(C(C)(C)O)c4ccccc4n3)sc12 CHEMBL3973823 IC50 2.6 nM
CCCC(=O)c1cccc2c(C)c(C(=O)Nc3cc(C(C)(C)O)c4ccccc4n3)sc12 CHEMBL3974107 IC50 2.6 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(C(=O)N4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 CHEMBL4109439 IC50 2.6 nM
c1cnc(O[C@H]2C[C@H](Nc3nc4ccccc4[nH]3)C2)c(C2CCOCC2)c1 CHEMBL3647600 IC50 2.627 nM
O[C@@H]1CC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690333 IC50 2.64 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)n(C)n3)nc12 CHEMBL3931252 IC50 2.68 nM
C[C@@H](CNC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1)c1ccccc1 CHEMBL3690279 IC50 2.69 nM
COC(C)(C)CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C CHEMBL3685569 IC50 2.7 nM
O=C(NC1COC1)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690006 IC50 2.7 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)ccc(F)c1F CHEMBL3690045 IC50 2.7 nM
CC(C)(O)CNC(=O)c1ccc(F)c(F)c1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690054 IC50 2.7 nM
CCCNc1nc2ccc(OC)cc2cc1Cc1c(=O)[nH]c(C)c2cc(OC)c(OC)cc12 CHEMBL3643858 IC50 2.7 nM
CNc1nc2cc3c(cc2cc1Cc1c(=O)[nH]c(C)c2cc(OC)c(OC)cc12)OCO3 CHEMBL3643879 IC50 2.7 nM
COc1ccc2nc(NCCNC(C)=O)c(Cc3c(=O)[nH]c(C)c4cc(OC)c(OC)cc34)cc2c1 CHEMBL3643892 IC50 2.7 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3CCN3CCCCC3)nc2n1 CHEMBL3703543 IC50 2.7 nM
COc1ccc(C)n2nc(/C=C/c3nc(-c4cccs4)cn3C)nc12 CHEMBL3668931 IC50 2.7 nM
Cc1ncc(C)n2nc(CCc3nc(-c4nccs4)cn3C)nc12 CHEMBL3668983 IC50 2.7 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cccc(C)n3)c(=O)n(C)n2)nc1 CHEMBL4113947 Ki 2.7 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2cc(C(F)(F)F)cn2)n1 CHEMBL3911815 Ki 2.7 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccccc2F)[nH]1 CHEMBL3634747 IC50 2.71 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(CCc3nc(N4CC[C@@H](F)C4)nn3C)nn12 CHEMBL4114887 IC50 2.71 nM
O=C(c1ccc(Oc2ncccc2C(=O)NCCc2ccccc2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690265 IC50 2.72 nM
CC(=O)c1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647621 IC50 2.74 nM
COc1ccc2c(n1)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691388 IC50 2.75 nM
COc1ccc2c(n1)CN(c1ncnn3c(C)nc([C@H]4CCOC4)c13)CC2 CHEMBL3695567 IC50 2.75 nM
CC(=O)N1CCC(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647593 IC50 2.766 nM
N#Cc1cc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)ccn1 CHEMBL3690253 IC50 2.78 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c([C@@H]2CCCOCC2)c1 CHEMBL3694454 IC50 2.79 nM
COc1ccc2nc(C)c3c(C)nc(-c4sccc4C)n3c2n1 CHEMBL1915906 IC50 2.8 nM
CC(C)(O)C1CCN(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3086100 IC50 2.8 nM
CNC(=O)c1ccc(-c2nccnc2C2CCN(c3ccc4cc(F)ccc4n3)CC2)cc1F CHEMBL3675647 IC50 2.8 nM
Cc1cccc2nc(CCc3nc(-c4ccccc4)cn3CCN3CCN(C)C3=O)nn12 CHEMBL3703560 IC50 2.8 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCCF CHEMBL3685588 IC50 2.8 nM
CNC(=O)c1cccc(F)c1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690018 IC50 2.8 nM
Cc1cccc2nc(CCc3nc(-c4ccccc4)c[nH]3)nn12 CHEMBL3703530 IC50 2.8 nM
Cc1cc(-c2ccccc2)n2nc(CCc3nc(-c4ccccc4)cn3C)nc2n1 CHEMBL3703539 IC50 2.8 nM
Cc1cccc2nc(CCc3nc(-c4cccs4)cn3C[C@@H](O)CCl)nn12 CHEMBL3668939 IC50 2.8 nM
CCc1nc(CC)n(-c2cc([C@@H]3C[C@H]3c3nc4ccccc4n3C)nc(C)n2)n1 CHEMBL4108215 Ki 2.8 nM
Cc1nc(C2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3928177 Ki 2.8 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nc(C)nn3C)c(=O)n(C)n2)nc1 CHEMBL4113110 Ki 2.8 nM
Cc1nc([C@H](C)O)n(-c2cc(C3C[C@H]3c3nc4ccccc4n3C)nc(C(F)(F)F)n2)n1 CHEMBL3948038 Ki 2.8 nM
OC[C@@H]1CCCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647665 IC50 2.81 nM
O=C(O)C1CCN(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL2206226 IC50 2.82 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C)n2)nc1 CHEMBL4108826 Ki 2.835 nM
COc1ccc2nc(C)c3c(C)nc(C4CCCCC4)n3c2n1 CHEMBL1085405 IC50 2.84 nM
O=C1C=C(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690287 IC50 2.84 nM
COc1cc2nncc(-c3cnc(N4CCC(O)(c5ccc(F)nc5)CC4)c(C)c3)c2cc1OC CHEMBL3393195 IC50 2.86 nM
C[C@]1(O)CC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3694436 IC50 2.86 nM
O[C@@H]1CCC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3694448 IC50 2.86 nM
COc1cc(F)c2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2c1 CHEMBL1916139 IC50 2.9 nM
CNC(=O)c1c(NC(=O)c2nc(C3CCOC3)cnc2Nc2cncnc2)cnn1C CHEMBL3685578 IC50 2.9 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC[C@@H]1CCCO1 CHEMBL3689986 IC50 2.9 nM
CC(C)c1ncc(Nc2cncnc2)c(C(=O)Nc2cccnc2C(=O)NCC(C)(C)O)n1 CHEMBL3690057 IC50 2.9 nM
Cc1ncc(C)n2nc(CCc3nc(-c4ccoc4)cn3C)nc12 CHEMBL3668989 IC50 2.9 nM
Cc1nc([C@H]2C[C@@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C2CC2)n1 CHEMBL3950949 Ki 2.9 nM
Cc1nc([C@H]2C[C@@H]2c2nc3ccccc3n2CCF)cc(-n2nc(C)nc2C)n1 CHEMBL3987143 Ki 2.9 nM
COc1cc2cncc(Cc3cnc4ccc(O)cc4c3)c2cc1OC CHEMBL3899450 IC50 2.9 nM
Cc1ncsc1CNc1nc(-n2ncc3ccccc32)nc(N)c1Br CHEMBL3893215 IC50 2.9 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCNCC4)c4ccccc4n3)c(C)c12 CHEMBL3966796 IC50 2.9 nM
Cc1cc(C)n2nc(CCc3cc(O)n4nc5ncccc5c4n3)nc2n1 CHEMBL4469155 IC50 2.9 nM
Cc1nc(C)c2c(n1)CCN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)C2 CHEMBL3691407 IC50 2.92 nM
COc1cc(Br)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 CHEMBL3739662 IC50 2.95 nM
O=C(c1ccc(Oc2ncccc2C(=O)NCCc2cccs2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690271 IC50 2.95 nM
NC(=O)c1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647629 IC50 2.96 nM
Cn1ccc2ccc(-c3nccnc3C3CN(c4ncc5ccccc5n4)C3)cc21 CHEMBL3687068 IC50 2.98 nM
COc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccc1F CHEMBL3687107 IC50 2.98 nM
COc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687084 IC50 2.99 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(OC)cc3c(N[C@H](C)C(=O)O)c2C#N)cc1 CHEMBL248059 IC50 3.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NC(Cc3ccccc3)C(=O)O)c2C#N)cc1 CHEMBL245710 IC50 3.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NCCCC(=O)O)c2C#N)cc1 CHEMBL393646 IC50 3.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CC[C@@H](O)C3)c2c1 CHEMBL1939912 Ki 3.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOC(C)C3)c2c1 CHEMBL1939915 Ki 3.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(N3CCC(C(N)=O)CC3)c2c1 CHEMBL1939797 Ki 3.0 nM
Cc1ncc(C(O)c2c3cc(Cl)cc(C)c3nc3[nH]nc(C)c23)cn1 CHEMBL1950091 Ki 3.0 nM
N#Cc1c(-c2ccc(-c3ccccc3C(F)(F)F)cc2)nc2ccncc2c1O CHEMBL1955881 IC50 3.0 nM
CC(C)c1ccccc1-c1ccc(-c2nc3ccncc3c(O)c2C#N)cc1 CHEMBL1957375 IC50 3.0 nM
COc1cc2nncc(-c3ccc(NCC4CC4)nc3)c2cc1OC CHEMBL1956228 IC50 3.0 nM
Cc1ccncc1NC(=O)N1CCc2nc(-c3ccc(F)nc3)nc(OC(C)C)c2C1 CHEMBL2204543 Ki 3.0 nM
COc1cc2ncnc(N3CC(O)CC(c4ccccc4)C3)c2cc1OC CHEMBL3601555 IC50 3.0 nM
COc1cc2cnnc(N3CC(O)CC(c4ccccc4)C3)c2cc1OC CHEMBL3601556 IC50 3.0 nM
CC(C)n1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642199 IC50 3.0 nM
Cn1nc(-c2ccc(Cl)cn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642209 IC50 3.0 nM
Cn1nc(-c2cccc(Cl)n2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642210 IC50 3.0 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCCC(C)(C)O CHEMBL3685560 IC50 3.0 nM
N#Cc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686954 IC50 3.0 nM
N#Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686955 IC50 3.0 nM
CC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686961 IC50 3.0 nM
COc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3686964 IC50 3.0 nM
c1ccc2nc(N3CC(c4nccnc4N4CC5CC5C4)C3)ccc2c1 CHEMBL3686996 IC50 3.0 nM
c1ccc2nc(N3CC(c4nccnc4N4CCCC4)C3)ccc2c1 CHEMBL3687001 IC50 3.0 nM
CC(C)(C)OC(=O)N1CC2CN(c3nccnc3C3CN(c4ccc5ccccc5n4)C3)CC2C1 CHEMBL3687003 IC50 3.0 nM
c1ccc2nc(N3CC(c4nccnc4N4CCCCCC4)C3)ccc2c1 CHEMBL3687013 IC50 3.0 nM
C(#Cc1nc2c(N3CCOCC3)ccnn2c1-c1ccc(N2CCNCC2)nc1)c1ccc2ccccc2n1 CHEMBL3937143 IC50 3.0 nM
O=C(O)CNc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3941093 IC50 3.0 nM
Oc1nc(-c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cn2)no1 CHEMBL3891084 IC50 3.0 nM
O=C(O)CCNC(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3962236 IC50 3.0 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1O CHEMBL3925279 IC50 3.0 nM
O=C(O)c1ccc(-c2c(CCc3ccc4c(n3)CCCC4)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3928461 IC50 3.0 nM
O=C(O)CCNc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3959880 IC50 3.0 nM
COc1cc(C(=O)O)ccc1-c1c(/C=C/c2ccc3ccccc3n2)nc2c(N3CCOCC3)ccnn12 CHEMBL3975601 IC50 3.0 nM
O=C(O)C1CCN(c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2)CC1 CHEMBL3980460 IC50 3.0 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1F CHEMBL3966136 IC50 3.0 nM
CS(=O)(=O)NC(=O)c1cccc2nc(/C=C/c3cn4nc(Cl)cc(N5CCOCC5)c4n3)ccc12 CHEMBL3957157 IC50 3.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(CSc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3985499 IC50 3.0 nM
O=C(O)c1cccc2nc(/C=C/c3nc4c(N5CCOCC5)ccnn4c3-c3cccnc3)ccc12 CHEMBL3977140 IC50 3.0 nM
CS(=O)(=O)NC(=O)C1CCN(c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)CC1 CHEMBL3890317 IC50 3.0 nM
O=C(O)c1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1 CHEMBL3974411 IC50 3.0 nM
CN1C(=O)NS(=O)(=O)c2cc(-c3cnc(N4CCOCC4)c4nc(/C=C/c5ccc6ccccc6n5)cn34)ccc21 CHEMBL3929831 IC50 3.0 nM
CN1c2cc(-c3cnc(N4CCOCC4)c4nc(/C=C/c5ccc6ccccc6n5)cn34)ccc2NS1(=O)=O CHEMBL3892914 IC50 3.0 nM
C(=C/c1cn2c(-c3ccc(-c4nnn[nH]4)nc3)cnc(N3CCOCC3)c2n1)\c1ccc2ccccc2n1 CHEMBL3911511 IC50 3.0 nM
CCOCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(C(C)(C)O)c4ccccc4n3)c(C)c12 CHEMBL3961394 IC50 3.0 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C(C)(C)O)cccc4n3)c(C)c12 CHEMBL3986517 IC50 3.0 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cc2C(F)(F)F)nc1 CHEMBL4108631 Ki 3.016 nM
COCCn1c(C)c(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)ccc1=O CHEMBL4112154 Ki 3.065 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(-n4cc(CCF)nn4)c4ccccc4n3)cc2)n1 CHEMBL3628722 IC50 3.07 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(OC3CCOCC3)c2c1 CHEMBL1939812 Ki 3.1 nM
CNC(=O)c1ccc(-c2nccnc2C2CCN(c3ccc4ccccc4n3)CC2)cc1F CHEMBL3639745 IC50 3.1 nM
Cc1nc(C)c(CNc2nc(OCC#Cc3ccccn3)nc(Cl)c2C)s1 CHEMBL3745797 Ki 3.1 nM
Cc1nc(C)c(CNc2nc(CCCOc3ccccn3)nc(Cl)c2C)s1 CHEMBL3745991 Ki 3.1 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)NC2CC2)n1 CHEMBL3685457 IC50 3.1 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)NC2CCC2)n1 CHEMBL3685459 IC50 3.1 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)NCC(C)(C)O)n1 CHEMBL3685469 IC50 3.1 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cccc1OC CHEMBL3685608 IC50 3.1 nM
CC(C)Cc1ncc(Nc2cncnc2)c(C(=O)Nc2cccnc2C(=O)NCC(C)(C)O)n1 CHEMBL3690059 IC50 3.1 nM
COCCn1cc(-c2ccccc2)nc1CCNC(=O)c1c(C(=O)N2CCC2)cnn1C CHEMBL3649551 IC50 3.1 nM
Cc1ncc(C)n2nc(CCc3cn4c(n3)-c3cc(F)ccc3C4)nc12 CHEMBL3698373 IC50 3.1 nM
Cc1ccc(C)n2nc(CCc3c[nH]c(-c4cncs4)n3)nc12 CHEMBL3681982 IC50 3.1 nM
COc1ccc(C)n2nc(CCc3nc(-c4cscc4C)cn3C)nc12 CHEMBL3668984 IC50 3.1 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2CF)n1 CHEMBL4111290 Ki 3.1 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(N3CCN(C)CC3)n2)n1 CHEMBL3944299 Ki 3.1 nM
CCOC(=O)Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3896310 Ki 3.1 nM
Cc1cn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)nn1 CHEMBL3946428 Ki 3.1 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C(C)C)n1 CHEMBL3950056 Ki 3.1 nM
Cc1ccc(CCNC(=O)c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)cc1 CHEMBL3690270 IC50 3.11 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CC(F)(F)F)c2)nc1 CHEMBL4107026 Ki 3.113 nM
NC(=O)C1CCN(c2nccnc2C2CN(C(=O)c3nc4ccccc4[nH]3)C2)CC1 CHEMBL3682211 IC50 3.12 nM
COC1CCN(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690269 IC50 3.16 nM
OCC1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647638 IC50 3.16 nM
COc1cc(Br)cc2c1nc(C)c1c(C)nc(-c3ccnc(F)c3)n12 CHEMBL3741528 IC50 3.18 nM
COC(=O)N1CCC(c2cccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647636 IC50 3.18 nM
c1cnc(O[C@H]2C[C@H](Nc3nc4ccccc4s3)C2)c(C2CCOCC2)c1 CHEMBL3647602 IC50 3.195 nM
COc1cc2nncc(-c3cnc(N4CCC(C)(O)CC4)c(C)c3)c2cc1OC CHEMBL1956249 IC50 3.2 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)N2CCC(F)(F)C2)n1 CHEMBL3685462 IC50 3.2 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1CCO CHEMBL3689995 IC50 3.2 nM
CCCc1[nH]c(=O)c(Cc2ccc3nc(C)ccc3c2)c2cc(OC)c(OC)cc12 CHEMBL3643899 IC50 3.2 nM
Cc1ncc(-c2cnn(C)c2)c(OC[C@H]2C[C@@H]2c2ccn(C)n2)n1 CHEMBL3699657 Ki 3.2 nM
COc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)c1 CHEMBL3904064 Ki 3.2 nM
C#CCNc1nc(-n2ncc3ccncc32)nc(N)c1Br CHEMBL3973761 IC50 3.2 nM
Cc1c(Cl)cc(OC[C@H]2C[C@@H]2c2ccccn2)nc1NCc1cnn(C)c1 CHEMBL5437188 Ki 3.2 nM
COc1ccc(Cn2nc(CCc3nc4c(Cl)cc(Cl)c(C)n4n3)nc2N2CCCC2)cc1 CHEMBL3925478 IC50 3.23 nM
C[C@@H]1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647655 IC50 3.24 nM
Cc1ncc(-c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647617 IC50 3.25 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)nn3CC(F)F)nc12 CHEMBL3944716 IC50 3.25 nM
CSc1cncc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)c1 CHEMBL3694478 IC50 3.26 nM
Cc1nc([C@H]2CCOC2)c2c(N3CCn4ncc(C(F)(F)F)c4C3)ncnn12 CHEMBL3691419 IC50 3.27 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4cnn(C)c4C3)ncnn12 CHEMBL3695547 IC50 3.28 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(N3CCN(C(N)=O)[C@@H](C)C3)c2c1 CHEMBL1939792 Ki 3.3 nM
COc1cccc2c1nnc1c(C)nc(-c3ccccc3C)n12 CHEMBL2070647 IC50 3.3 nM
Cc1nc2ccccc2nc1CCc1nc(C(=O)NC[C@@H]2CCCO2)cc(N2CCCC2)n1 CHEMBL2180439 IC50 3.3 nM
O=c1ccc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)[nH]1 CHEMBL3634865 IC50 3.3 nM
COc1cc(-c2ccc(F)nc2)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 CHEMBL3741850 IC50 3.3 nM
O=C(NCCO)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685493 IC50 3.3 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC[C@H]1CCCO1 CHEMBL3689987 IC50 3.3 nM
COc1ccc(COc2cc(-n3nc(C)nc3Cc3ccc(OC)c(OC)c3)nc(C)n2)nc1 CHEMBL3970286 Ki 3.3 nM
CCN(CC)c1nc2ccc(NC(=O)c3c(C(=O)N4CCCC4)cnn3C)cn2n1 CHEMBL3892738 IC50 3.3 nM
CCN(CC)c1nc2ccc(NC(=O)c3c(C(=O)N4CCC4)cnn3C)cn2n1 CHEMBL3959039 IC50 3.3 nM
CCc1nc(CC)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)n1 CHEMBL3889666 Ki 3.3 nM
O=c1[nH]c(-c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2)no1 CHEMBL3891196 IC50 3.3 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4C(F)(F)F)n3c2c1 CHEMBL2070650 IC50 3.35 nM
CS(=O)(=O)Nc1ccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)cc1 CHEMBL3687064 IC50 3.36 nM
O=C(NC1CC1)c1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686978 IC50 3.37 nM
Cc1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647615 IC50 3.39 nM
COc1nc2cccnc2n1[C@H]1C[C@@H](Nc2nc3ccccc3s2)C1 CHEMBL3287906 IC50 3.4 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(C(C)(C)C)ncc1Nc1cncnc1 CHEMBL3685502 IC50 3.4 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC(C)(C)CO CHEMBL3685570 IC50 3.4 nM
CC(C)(O)c1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3691521 IC50 3.4 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3C(C)C)nc2n1 CHEMBL3703545 IC50 3.4 nM
CCCn1cc(-c2cccs2)nc1CCc1cn2c(C)cc(C)nc2n1 CHEMBL3668906 IC50 3.4 nM
Cc1cccc([C@H]2C[C@@H]2COc2cc(NCc3ccccn3)c(=O)n(C)n2)n1 CHEMBL4111228 Ki 3.4 nM
CCc1cnn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)c1 CHEMBL3910729 Ki 3.4 nM
Nc1nc(-n2cncn2)nc(NCC2CC2)c1Br CHEMBL3951232 IC50 3.4 nM
Cc1nc([C@@H]2CCOC2)c2c(N3CCc4cnn(C)c4C3)ncnn12 CHEMBL3695560 IC50 3.41 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)nn1C1CC1 CHEMBL3649575 IC50 3.41 nM
CCc1cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn2c1C CHEMBL3921749 IC50 3.44 nM
Cc1c(C#N)ccc2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3898663 IC50 3.47 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(CC#N)c2)nc1 CHEMBL4113912 Ki 3.477 nM
Fc1cnc(O[C@H]2C[C@@H](Nc3nc4cc(F)ccc4s3)C2)c(C2CCOCC2)c1 CHEMBL3647609 IC50 3.49 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(F)cc(OC(F)F)cc3n12 CHEMBL1916136 IC50 3.5 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC1CCOC1 CHEMBL3685561 IC50 3.5 nM
CNC(=O)c1nc(C)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685599 IC50 3.5 nM
CNC(=O)c1cc(C#N)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689992 IC50 3.5 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)N[C@@H]1CCOC1 CHEMBL3690009 IC50 3.5 nM
CCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NC(C)C)c2cc(OC)c(OC)cc12 CHEMBL3643863 IC50 3.5 nM
Cc1ncc(C)n2nc(CCc3c[nH]c(-c4cscn4)n3)nc12 CHEMBL3681984 IC50 3.5 nM
Cc1ccc(C)n2nc(CCc3c[nH]c(-c4cscn4)n3)nc12 CHEMBL3681985 IC50 3.5 nM
Cc1ccc(-c2nc(CCc3nc4c(C)ncc(C)n4n3)cn2C)o1 CHEMBL3681993 IC50 3.5 nM
Cc1ncc(C)n2nc(-c3cc4nc(-c5ccccc5)cn4cc3N3CCCC3)nc12 CHEMBL3703190 IC50 3.5 nM
Cc1nc(NCc2cnn(C)c2)cc(OC[C@H]2C[C@@H]2c2ccc(C(F)F)cn2)n1 CHEMBL3659062 Ki 3.5 nM
Cc1nc(C2CC2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C)n1 CHEMBL3934377 Ki 3.5 nM
CCc1ncc(Cc2ccc3cccc(NS(=O)(=O)CC)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3979133 IC50 3.5 nM
CCc1ncc(Cc2cnc3ccc(NC(=O)C(N)=O)cc3c2)c2cc(OC)c(OC)cc12 CHEMBL3923399 IC50 3.5 nM
CCN(CC)C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(N3CCCC3)nn2c1 CHEMBL3934936 IC50 3.5 nM
COC1CCN(c2nc3ccc(NC(=O)c4c(C(=O)N(C)C5CC5)cnn4C)cn3n2)C1 CHEMBL3979072 IC50 3.5 nM
COc1cc(F)cc2c1nnc1c(C)nc(-c3cccc(F)c3C)n12 CHEMBL2070659 IC50 3.55 nM
Clc1ccc(C2=CCOCC2)c(O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)n1 CHEMBL3647612 IC50 3.55 nM
CN(C)C(=O)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3691478 IC50 3.55 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccncc4Cl)n3c2n1 CHEMBL1916095 IC50 3.6 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(N3CCCOCC3)c2c1 CHEMBL1939789 Ki 3.6 nM
CNC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ncc(Cl)cc4n3)C2)cc1F CHEMBL3675657 IC50 3.6 nM
Cc1nc(C)c(CNc2nc(OCC3CC3c3ncccn3)nc(Cl)c2C)s1 CHEMBL3746957 Ki 3.6 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC1(C)COC1 CHEMBL3685556 IC50 3.6 nM
CCCc1cc(C)nc2nc(CCc3nc(-c4ccccc4)cn3C)nn12 CHEMBL3703551 IC50 3.6 nM
COc1cccnc1[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)c2)nc(C)n1 CHEMBL3659061 Ki 3.6 nM
Cc1nnc(CNc2nc(N)nc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)c2F)s1 CHEMBL3659071 Ki 3.6 nM
COc1cc2cncc(Cc3ccc4c(c3)oc(=O)n4C)c2cc1OC CHEMBL3957044 IC50 3.6 nM
Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)nn1C CHEMBL4110105 Ki 3.6 nM
OCC1CCCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647643 IC50 3.62 nM
Cc1nc2c(c(C(F)(F)F)n1)CN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)CC2 CHEMBL3691457 IC50 3.64 nM
O=C(c1ccc(Oc2ncccc2C(=O)N[C@H](CO)Cc2ccc(O)cc2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690263 IC50 3.65 nM
COC(=O)Cn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(OC)cn2)ccc1=O CHEMBL4115406 Ki 3.65 nM
C[C@@]1(O)CCC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690311 IC50 3.66 nM
COc1ccc2nc(C)c3c(C)nc(-c4sc(C)nc4C)n3c2n1 CHEMBL1915912 IC50 3.7 nM
CNC(=O)c1nc(COC)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685624 IC50 3.7 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)nn1Cc1ccccc1 CHEMBL3649564 IC50 3.7 nM
OCC1CCN(c2nccnc2C2CN(c3ccc4cc(F)ccc4n3)C2)CC1 CHEMBL3691487 IC50 3.7 nM
Cn1c(C(=O)c2ccc(Oc3ncccc3-c3cccnc3)cc2)nc2ccccc21 CHEMBL3393204 IC50 3.73 nM
O[C@H]1CCC[C@@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690339 IC50 3.75 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)n[nH]1 CHEMBL3649555 IC50 3.77 nM
CCc1cnc(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc12 CHEMBL3934495 IC50 3.78 nM
COc1cc2c(cc1OC)-c1c(-c3cnc(CN4CCCOCC4)s3)ncn1CC2 CHEMBL2017067 Ki 3.8 nM
CCn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCC(C)C CHEMBL3685618 IC50 3.8 nM
NC(=O)c1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)cn1 CHEMBL3639464 IC50 3.8 nM
Cc1nc(NCc2nnc(C3CC3)s2)cc(OC[C@H]2C[C@@H]2c2ccccn2)n1 CHEMBL3659064 Ki 3.8 nM
C=Cc1c([C@@H]2C[C@H]2c2cc(-n3nc(C)nc3C)nc(C)n2)nc2ccccn12 CHEMBL4111675 Ki 3.8 nM
C[C@]1(O)CCC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)C1 CHEMBL3690298 IC50 3.82 nM
CCOc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686973 IC50 3.88 nM
COc1cc(F)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL1916134 IC50 3.9 nM
CNC(=O)c1ccc(-c2nccnc2C2CN(c3ncc4cc(F)c(Cl)cc4n3)C2)cc1F CHEMBL3675655 IC50 3.9 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)N2CCCC2CO)n1 CHEMBL3685475 IC50 3.9 nM
CCNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C CHEMBL3685613 IC50 3.9 nM
CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690024 IC50 3.9 nM
CCc1[nH]c(=O)c(Cc2cc3cc(OCC4CC4)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 CHEMBL3643906 IC50 3.9 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)nc(NCc3nnc(C)s3)c2Cl)nc1 CHEMBL3659067 Ki 3.9 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C2CCN(C)CC2)n1 CHEMBL4110282 Ki 3.9 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C2CC(=O)N(C)C2)n1 CHEMBL3910763 Ki 3.9 nM
c1ccc2nc(N3CC(c4nccnc4N4CCCCC4)C3)ccc2c1 CHEMBL3687109 IC50 3.93 nM
c1ccc2nc(N3CC(c4nccnc4N4CC5CCCC5C4)C3)ccc2c1 CHEMBL3687025 IC50 3.96 nM
COc1cc(N2CCOCC2)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2070656 IC50 3.99 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c(-c2ccncc2)c1 CHEMBL3690196 IC50 3.99 nM
Cc1cccc(-c2nc3ccccc3nc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687098 IC50 3.99 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NCCCC(=O)O)c2C#N)c(F)c1 CHEMBL246141 IC50 4.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(N[C@@H](C)C(=O)O)c2C#N)cc1 CHEMBL397600 IC50 4.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(N(C)CC(=O)O)c2C#N)cc1 CHEMBL245788 IC50 4.0 nM
COc1cc2ncnc(N3CC[C@@H](Oc4cnc5ccccc5n4)C3)c2cc1OC CHEMBL219445 Ki 4.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(C(C)(O)c3ccncc3)c2c1 CHEMBL1950082 Ki 4.0 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(Cl)c3)c2cc1OC CHEMBL1956236 IC50 4.0 nM
CNC(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3675650 IC50 4.0 nM
CCOC(=O)Cn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642187 IC50 4.0 nM
Cn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3642193 IC50 4.0 nM
Cc1cnc(Nc2cncnc2)c(C(=O)Nc2cc(-c3ccccn3)nn2CCO)n1 CHEMBL3957823 IC50 4.0 nM
CN1CCC(n2nc(-c3ccccn3)cc2NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)CC1 CHEMBL3642212 IC50 4.0 nM
O=C(Nc1cc(-c2ccccn2)no1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642220 IC50 4.0 nM
Cn1nc(-c2ccccn2)cc1NC(=O)c1nc(C(C)(C)C)ncc1Nc1cncnc1 CHEMBL3642224 IC50 4.0 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCC1CCCO1 CHEMBL3689964 IC50 4.0 nM
Cn1cc(-c2ccccc2)nc1CCNC(=O)c1c(C(=O)N2CCC2)cnn1C CHEMBL3649526 IC50 4.0 nM
CCCc1[nH]c(=O)c(Cc2cnc3cc(OC)ccc3c2)c2cc(OC)c(OC)cc12 CHEMBL3643852 IC50 4.0 nM
Fc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686952 IC50 4.0 nM
c1ccc2nc(N3CC(c4nccnc4-c4ccncc4)C3)ccc2c1 CHEMBL3686953 IC50 4.0 nM
CSc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686960 IC50 4.0 nM
OCC1(CC2CC2)CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687047 IC50 4.0 nM
COc1ccc(C)n2nc(CCc3nc(-c4ccoc4)cn3C)nc12 CHEMBL3668979 IC50 4.0 nM
O=C(O)CCNC(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3897208 IC50 4.0 nM
O=C(O)CCC(=O)Nc1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3973082 IC50 4.0 nM
Oc1ncn(-c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cn2)n1 CHEMBL3961662 IC50 4.0 nM
Oc1nnnn1-c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3956297 IC50 4.0 nM
Oc1nc(O)c(-c2ccc(-c3c(CCc4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2)o1 CHEMBL3915787 IC50 4.0 nM
CC(C)[C@H](NC(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1)C(=O)O CHEMBL3925892 IC50 4.0 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3909385 IC50 4.0 nM
CC(C)[C@H](NC(=O)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1)C(=O)O CHEMBL3951558 IC50 4.0 nM
C(=C/c1nc2c(N3CCOCC3)ccnn2c1-c1cccc(-c2nnn[nH]2)c1)\c1ccc2ccccc2n1 CHEMBL3929596 IC50 4.0 nM
CS(=O)(=O)NC(=O)c1cccc2nc(/C=C/c3nc4c(N5CCOCC5)ccnn4c3-c3ccccc3)ccc12 CHEMBL3922911 IC50 4.0 nM
O=C(O)c1cccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)c1 CHEMBL3944569 IC50 4.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1F CHEMBL3966593 IC50 4.0 nM
CS(=O)(=O)NC(=O)c1cccc2nc(/C=C/c3nc4c(N5CCOCC5)ccnn4c3-c3ccccn3)ccc12 CHEMBL3910240 IC50 4.0 nM
c1ccc2nc(C3CC3c3cn4nccc(N5CCOCC5)c4n3)ccc2c1 CHEMBL3974282 IC50 4.0 nM
Cc1ncc(C)n2nc(CCc3ccc4cc5c(cc4n3)OCCO5)nc12 CHEMBL3948926 IC50 4.0 nM
O=C(O)CCC(=O)Nc1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1 CHEMBL3893224 IC50 4.0 nM
Oc1ncn(-c2ccc(-c3cnc(N4CCOCC4)c4nc(CCc5ccc6ccccc6n5)cn34)cc2)n1 CHEMBL3922879 IC50 4.0 nM
CC(=O)NS(=O)(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(/C=C/c4ccc5ccccc5n4)cn23)cc1 CHEMBL3980000 IC50 4.0 nM
Cc1cc(C(F)(F)F)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)n1 CHEMBL3984948 Ki 4.0 nM
Cc1c(C(=O)Nc2cc(C(C)(C)O)c3ccccc3n2)sc2c(C(=O)C3CCCC3)cccc12 CHEMBL3918232 IC50 4.0 nM
Cc1ccc(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc12 CHEMBL3981267 IC50 4.0 nM
COc1cncc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)c1 CHEMBL3694429 IC50 4.08 nM
O=C(c1ccc(Oc2nccnc2N2CCC(O)CC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3086097 IC50 4.1 nM
COc1nc2cccnc2n1-c1ccc(Nc2ccc(C)cn2)cc1 CHEMBL3287662 IC50 4.1 nM
Cc1nc(C)c(CNc2nc(NCCCc3ccccn3)nc(Cl)c2C)s1 CHEMBL3746862 Ki 4.1 nM
Cn1c(OCCOc2cn(CC3CC3)nc(-c3ccnn3-c3ccccc3)c2=O)nc2ccccc21 CHEMBL3814367 IC50 4.1 nM
O=C(NCC(O)CO)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685494 IC50 4.1 nM
CNC(=O)c1c(NC(=O)c2nc(N3CCOCC3)cnc2Nc2cncnc2)cnn1C CHEMBL3690025 IC50 4.1 nM
C#CCn1cc(-c2cccs2)nc1CCc1nc2c(OC)ccc(C)n2n1 CHEMBL3668975 IC50 4.1 nM
Cc1noc(C)c1CNc1cc(OC[C@H]2C[C@@H]2c2ccn(C)n2)nn(C)c1=O CHEMBL4106504 Ki 4.1 nM
Cc1nc([C@@H]2CCOC2)c2c(N3Cc4c(cnn4C)C(C)C3)ncnn12 CHEMBL3695546 IC50 4.11 nM
COc1ccnc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)c1 CHEMBL3694481 IC50 4.11 nM
COc1ncccc1-c1nccnc1O[C@H]1C[C@@H](Nc2nc3ccccc3s2)C1 CHEMBL3647616 IC50 4.11 nM
COc1cc(OC)c2nnc3c(C)nc(-c4cnccc4C)n3c2c1 CHEMBL2070652 IC50 4.16 nM
COc1ccc2nc(C)c3c(C)nc(-c4cccnc4C)n3c2n1 CHEMBL1916090 IC50 4.2 nM
CC(C)(O)C1CCN(c2nccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL2206224 IC50 4.2 nM
O=C(Nc1cnccc1C(=O)N1CCC1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685492 IC50 4.2 nM
COCC(C)NC(=O)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685497 IC50 4.2 nM
CC(=O)N1CCC(c2cccnc2Oc2ccc([C@H](O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3690285 IC50 4.2 nM
Cc1ncc(C)n2nc(CCc3c[nH]c(-c4ccccc4)n3)nc12 CHEMBL3681977 IC50 4.2 nM
Cn1c(=O)[nH]c2ccc(-c3nccnc3C3CN(c4ncc5ccccc5n4)C3)cc21 CHEMBL3687071 IC50 4.2 nM
CC(C)(O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3691522 IC50 4.2 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2nnc(C3CC3)s2)nc1 CHEMBL3699659 Ki 4.2 nM
Cc1cc(C)n2nc(CSc3nc(-c4ccccc4)cn3CC(C)C)nc2n1 CHEMBL3703531 IC50 4.2 nM
Cc1cc(C)n2nc(CCc3nc(-c4cccs4)cn3C)nc2n1 CHEMBL3668932 IC50 4.2 nM
Cc1ccc(-c2cn(C)c(CCc3nc4c(C)ccc(C)n4n3)n2)o1 CHEMBL3668987 IC50 4.2 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C(C)(C)O)n1 CHEMBL4113615 Ki 4.2 nM
Cc1nc(C)n(-c2cc([C@H]3C[C@@H]3c3nc4ccccc4n3C)nc(N)n2)n1 CHEMBL3959469 Ki 4.2 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2cc(C#N)cn2)n1 CHEMBL3981776 Ki 4.2 nM
Cc1nc(C2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2C(C)(C)O)n1 CHEMBL4113903 Ki 4.2 nM
Cc1c(Cl)cc(O)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3964618 IC50 4.22 nM
Cc1cnccc1-c1nccnc1O[C@H]1C[C@@H](Nc2nc3ccccc3s2)C1 CHEMBL3647613 IC50 4.23 nM
COC(=O)N1CCC(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647672 IC50 4.24 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(C(C)C)c2C)nc1 CHEMBL4115342 Ki 4.273 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1 CHEMBL1915892 IC50 4.3 nM
COc1cc2c(cc1OC)-c1c(-c3cnc(C(=O)NC4CCOCC4)s3)ncn1CC2 CHEMBL2017061 Ki 4.3 nM
c1ccc2sc(Nc3ccc(Oc4nccnc4N4CCOCC4)cc3)nc2c1 CHEMBL3086088 IC50 4.3 nM
CC(C)(O)CNC(=O)c1ccncc1NC(=O)c1nc(C(C)(C)C)ncc1Nc1cncnc1 CHEMBL3685516 IC50 4.3 nM
COc1cc2c(Cc3ccc4nc(C)ccc4c3)cnc(C)c2cc1OC CHEMBL3900509 IC50 4.3 nM
Nc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3687108 IC50 4.37 nM
COC(=O)Cn1cc(-c2cnc(C)nc2OC[C@H]2C[C@@H]2c2ccc(C)cn2)ccc1=O CHEMBL4113671 Ki 4.389 nM
COc1cc2nncc(-c3ccc(NC4CCCC4)nc3)c2cc1OC CHEMBL1956227 IC50 4.4 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3CCN3CCN(C)C3=O)nc2n1 CHEMBL3703564 IC50 4.4 nM
CC(C)CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C CHEMBL3685584 IC50 4.4 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 CHEMBL3643874 IC50 4.4 nM
Cc1ncc(C)n2nc(/C=C/c3cn4c(n3)-c3ccccc3C4)nc12 CHEMBL3659080 IC50 4.4 nM
COCC(=O)NC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687053 IC50 4.4 nM
c1ccc2nc(N3CC(c4nccnc4-c4ccc5scnc5c4)C3)ncc2c1 CHEMBL3687076 IC50 4.4 nM
Cc1ncc(C)n2nc(C=Cc3cn4c(n3)-c3ccccc3C4)nc12 CHEMBL3944180 IC50 4.4 nM
CCCc1ncc(Cc2ccc3c(c2)oc(=O)n3C)c2cc(OC)c(OC)cc12 CHEMBL3968092 IC50 4.4 nM
O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3ccncc3)n12 CHEMBL3986711 Ki 4.4 nM
COc1cc(NC(=O)c2sc3c(C(C)=O)ccc(C(C)=O)c3c2C)nc2ccccc12 CHEMBL3979787 IC50 4.4 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)[nH]n2)nc1 CHEMBL4115324 Ki 4.416 nM
Oc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3687104 IC50 4.42 nM
CCn1nc(C#Cc2nc3c(C)ncc(C)n3n2)nc1N1CCCC1 CHEMBL3910603 IC50 4.48 nM
Cc1ccn2nc(CCc3nc(N4CCCC4)nn3C)nc2c1C CHEMBL3984028 IC50 4.49 nM
CC(C)Oc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)c1cn(C)cn1)CC2 CHEMBL2204537 Ki 4.5 nM
O=C(c1ccc(Oc2nccnc2N2CCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3086091 IC50 4.5 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)NC2CCCC2)n1 CHEMBL3685460 IC50 4.5 nM
CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C CHEMBL3685539 IC50 4.5 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NCC(C)(C)O CHEMBL3685542 IC50 4.5 nM
O=C(Nc1ccc(F)cc1C(=O)N1CCC1)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690033 IC50 4.5 nM
COc1cccn2nc(CCc3nc(-c4cccs4)cn3C)nc12 CHEMBL3668933 IC50 4.5 nM
COCc1ncc(Cc2cnc3ccc(O)c(C(F)(F)F)c3c2)c2cc(OC)c(OC)cc12 CHEMBL3907937 IC50 4.5 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2C2CC2)n1 CHEMBL3986025 Ki 4.5 nM
C#CCNc1nc(-n2cc(-c3cnccn3)cn2)nc(N)c1Br CHEMBL3949622 IC50 4.5 nM
Cc1ncc2c(n1)CCN(c1ncnn3c(C)nc([C@@H]4CCOC4)c13)C2 CHEMBL3695517 IC50 4.51 nM
C[C@]1(O)CC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690326 IC50 4.51 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4nc(C5CC5)nc(C(F)(F)F)c4C3)ncnn12 CHEMBL3691459 IC50 4.55 nM
CC(C)Oc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)c1cn(C)cn1)CC2 CHEMBL2220083 Ki 4.55 nM
Cc1ncc(C)n2nc(CCc3nc(-c4ccco4)nn3C)nc12 CHEMBL2180417 IC50 4.6 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685430 IC50 4.6 nM
CC(C)(O)CNC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)ccc(F)c1F CHEMBL3690046 IC50 4.6 nM
CCCc1[nH]c(=O)c(Cc2cc3cc(OCC)ccc3nc2NCC)c2cc(OC)c(OC)cc12 CHEMBL3643868 IC50 4.6 nM
CCc1ncc(Cc2cnc3ccc(NS(N)(=O)=O)cc3c2)c2cc(OC)c(OC)cc12 CHEMBL3910973 IC50 4.6 nM
Oc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687103 IC50 4.65 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(-c3ccccc3)c2)nc1 CHEMBL4114146 Ki 4.683 nM
OCC1CCN(c2cnccc2OC2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3356651 IC50 4.7 nM
FCCn1cc(-c2ccncc2)c(-c2ccc(OCc3nc4ccccc4o3)cc2)n1 CHEMBL3963338 IC50 4.7 nM
CCCc1ncc(Cc2ccc3cccc(OCc4nnn[nH]4)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3918567 IC50 4.7 nM
COc1ccn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)n1 CHEMBL3933183 Ki 4.7 nM
Cc1c(C(=O)Nc2ccc3ccccc3n2)sc2c(-c3ccncc3)cccc12 CHEMBL4529098 IC50 4.7 nM
Cc1nc(C)c(CNc2nc(C3CC3)nc(Cl)c2C)s1 CHEMBL3622879 Ki 4.8 nM
Cc1nc([C@H]2CCOC2)c2c(N3CCc4ncccc4C3)ncnn12 CHEMBL3691465 IC50 4.8 nM
Cc1cc(C(C)C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc2n1 CHEMBL3703553 IC50 4.8 nM
CCC(=O)c1cccc2c(C)c(C(=O)Nc3cc(C(C)(C)O)c4ccccc4n3)sc12 CHEMBL3944660 IC50 4.8 nM
O=C(c1ccc(Oc2ncccc2-c2cccnc2)cc1)c1nc2ncccc2[nH]1 CHEMBL3690262 IC50 4.81 nM
Clc1ccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)cc1 CHEMBL3687057 IC50 4.82 nM
Cc1nc(-c2ccncc2)n2c1sc1cc(OCc3ccc4ccccc4n3)ccc12 CHEMBL3094141 IC50 4.85 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccc(=O)n(-c3ccccc3)c2)nc1 CHEMBL4114638 Ki 4.861 nM
COc1cc2nncc(-c3cnc(N4CCC(C(C)(C)O)CC4)c(C)c3)c2cc1OC CHEMBL1956250 IC50 4.9 nM
CC(C)NC(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689953 IC50 4.9 nM
COc1cccc(-c2nccnc2C2CN(c3ccc4cc(Cl)ccc4n3)C2)c1 CHEMBL3691512 IC50 4.9 nM
CCCc1ncc(Cc2ccc3cccc(OCC(=O)O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3942178 IC50 4.9 nM
COC1CCN(c2nc3ccc(NC(=O)c4c(C(=O)N5CCC5)cnn4C)cn3n2)C1 CHEMBL3941156 IC50 4.9 nM
CCc1ncc(C)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3947336 IC50 4.9 nM
CC(=O)N1CCC(c2nccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)CC1 CHEMBL3647633 IC50 4.93 nM
COc1cccc(-c2cccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687086 IC50 4.93 nM
O=C(c1ccc(Oc2ncccc2[C@@H]2CCCO2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690290 IC50 4.97 nM
OC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3691481 IC50 4.97 nM
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1 CHEMBL3629000 IC50 4.98 nM
Cc1cc(Cl)c(C)n2nc([C@H]3C[C@@H]3c3nc(N4CCCC4)nn3C)nc12 CHEMBL3961380 IC50 4.98 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NC(CC)C(=O)O)c2C#N)cc1 CHEMBL246799 IC50 5.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1 CHEMBL1940053 Ki 5.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(NCC3CNCCO3)c2c1 CHEMBL1939807 Ki 5.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(O)ccc3F)nnc12 CHEMBL3693264 IC50 5.0 nM
Cn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642181 IC50 5.0 nM
COCc1ccc(Nc2cncnc2)c(C(=O)Nc2cc(-c3ccccn3)nn2CCO)n1 CHEMBL3642184 IC50 5.0 nM
O=C(Nc1cc(-c2ccccn2)nn1CCc1ccccc1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642189 IC50 5.0 nM
CCn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3642202 IC50 5.0 nM
Cc1cc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)ccn1 CHEMBL3690218 IC50 5.0 nM
CCNc1nc2ccc(OCC)cc2cc1Cc1c(=O)[nH]c(CC)c2cc(OC)c(OC)cc12 CHEMBL3643861 IC50 5.0 nM
c1ccc(CC2CCN(c3nccnc3C3CN(c4ccc5ccccc5n4)C3)C2)cc1 CHEMBL3686992 IC50 5.0 nM
c1ccc(C2CCN(c3nccnc3C3CN(c4ccc5ccccc5n4)C3)C2)cc1 CHEMBL3687017 IC50 5.0 nM
Cc1cn(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 CHEMBL3687040 IC50 5.0 nM
Cc1cc(C)n2nc(CSc3nc(-c4ccccc4)cn3CCN3CCOCC3)nc2n1 CHEMBL3703532 IC50 5.0 nM
Oc1nc(-c2ccc(-c3c(COc4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cn2)no1 CHEMBL3922637 IC50 5.0 nM
CS(=O)(=O)NC(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3967258 IC50 5.0 nM
Oc1ncn(-c2ccc(-c3c(CCc4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2)n1 CHEMBL3946579 IC50 5.0 nM
O=C(O)CNC(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3906042 IC50 5.0 nM
O=C(O)c1ccc(-c2c(/C=C/c3ccc4c(n3)CCCC4)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3954844 IC50 5.0 nM
O=C(O)CCc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3945948 IC50 5.0 nM
O=C(O)c1ccc(Nc2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3970908 IC50 5.0 nM
O=C(O)CCC(=O)N1CCN(c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)CC1 CHEMBL3919110 IC50 5.0 nM
O=c1ncn(-c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2F)[nH]1 CHEMBL3902049 IC50 5.0 nM
C[C@H](N)C(=O)N[C@@H](CCCCNC(=O)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1)C(N)=O CHEMBL3901148 IC50 5.0 nM
NC(=O)[C@@H](N)CCCCNC(=O)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3972283 IC50 5.0 nM
CCc1ncc(Cc2ccc3cccc(OCCC(=O)O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3948839 IC50 5.0 nM
O=C(O)c1ccc(-c2cnc(N3CCOCC3)c3nc(/C=C/c4ccc5ccccc5n4)cn23)cc1F CHEMBL3904700 IC50 5.0 nM
CC(C)[C@H](NC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1)C(=O)O CHEMBL3923577 IC50 5.0 nM
O=C(O)CCNC(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(/C=C/c4ccc5ccccc5n4)cn23)cc1 CHEMBL3957064 IC50 5.0 nM
c1ccc2nc(CCc3cn4c(-c5ccc(-c6nnc[nH]6)nc5)cnc(N5CCOCC5)c4n3)ccc2c1 CHEMBL3925860 IC50 5.0 nM
O=c1[nH]c(-c2ccc(-c3cnc(N4CCOCC4)c4nc(/C=C/c5ccc6ccccc6n5)cn34)cn2)no1 CHEMBL3973393 IC50 5.0 nM
Cc1nc(N2CC(c3nc4ccccc4n3CCC#N)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3901097 Ki 5.0 nM
COc1ccc(Cn2nc(N3CCCC3)nc2CCc2nc3c(C)ncc(C)n3n2)cc1 CHEMBL3925880 IC50 5.0 nM
CCc1c(C(=O)Nc2cc(C(C)(C)O)c3ccccc3n2)sc2c(C(C)=O)ccc(C(C)=O)c12 CHEMBL3937512 IC50 5.0 nM
COc1cc(OC)c2nnc3c(c(-c4cccnc4C)nn3C)c2c1 CHEMBL4556703 IC50 5.0 nM
Cc1ccccc1-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 CHEMBL3634750 IC50 5.02 nM
COCC(=O)N1CCC(c2nccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)CC1 CHEMBL3647634 IC50 5.06 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cnc4ccccc4n3)cc2)n1 CHEMBL554906 IC50 5.09 nM
CC(=O)N1CCN(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3086099 IC50 5.1 nM
O=C(c1ccc(Oc2nccnc2N2CCCOCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3086094 IC50 5.1 nM
CCCOc1nc(Cl)c(C)c(NCc2sc(C)nc2C)n1 CHEMBL3622891 Ki 5.1 nM
COc1cc2cncc(Cc3coc4ccc(C)cc4c3=O)c2cc1OC CHEMBL3948369 IC50 5.1 nM
COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(-c3cnccc3C)n12 CHEMBL2070667 IC50 5.11 nM
Cc1nc([C@]23COC[C@H]2C3)n2c1sc1cc(OCc3ccc4ccccc4n3)ccc12 CHEMBL3094147 IC50 5.12 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4C)n3c2c1 CHEMBL2070649 IC50 5.13 nM
Cc1nc2ccc(Cl)cc2nc1C#Cc1nc(N2CCCC2)nn1C CHEMBL3964339 IC50 5.17 nM
OCc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686981 IC50 5.19 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccncc4C)n3c2n1 CHEMBL1916094 IC50 5.2 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685433 IC50 5.2 nM
CC(NC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C)C(F)(F)F CHEMBL3685581 IC50 5.2 nM
CNC(=O)c1ncncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689950 IC50 5.2 nM
CCCc1ncc(Cc2cnc3cc(C)ccc3c2)c2cc(OC)c(OC)cc12 CHEMBL3928633 IC50 5.2 nM
CCc1c(C(=O)Nc2ccc3ccccc3n2)sc2c(-c3ccncc3)cccc12 CHEMBL4439744 IC50 5.2 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4cc(C5CC5)ncc4C3)ncnn12 CHEMBL3695542 IC50 5.21 nM
c1cnc(C2CN(c3ccc4ccccc4n3)C2)c(N2CCCCC2)c1 CHEMBL3687089 IC50 5.22 nM
OCC1CCN(c2nccnc2C2CN(c3cnc4ccccc4n3)C2)CC1 CHEMBL3691543 IC50 5.22 nM
c1ccc2nc(N3CC(c4nccnc4-c4ccc5cc[nH]c5c4)C3)ncc2c1 CHEMBL3687066 IC50 5.25 nM
N#C[C@H]1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647667 IC50 5.27 nM
N#CC1CCN(c2nccnc2C2CN(C(=O)c3nc4ccccc4[nH]3)C2)CC1 CHEMBL3682198 IC50 5.29 nM
Cc1ccc(C)n2nc(CCc3nc(-c4ccsc4)nn3C)nc12 CHEMBL2180416 IC50 5.3 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC1CCCC1O CHEMBL3690064 IC50 5.3 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)c[nH]3)nc2n1 CHEMBL3703527 IC50 5.3 nM
Cc1nc(NCc2ccncc2C)cc(OC[C@H]2C[C@@H]2c2ccccn2)n1 CHEMBL3659076 Ki 5.3 nM
COCc1ncnn1-c1cc([C@@H]2C[C@H]2c2nc3ccccc3n2C)nc(C)n1 CHEMBL4114516 Ki 5.3 nM
CN(C)c1nc2ccc(NC(=O)c3c(C(=O)N(C)C4CC4)cnn3C)cn2n1 CHEMBL3952016 IC50 5.3 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3ccc(F)c(C)n3)c(=O)n(C)n2)nc1 CHEMBL4110213 Ki 5.3 nM
Cc1cc(C)n2cc(CSc3nc(-c4ccccc4)cn3CCC(C)C)nc2n1 CHEMBL3700109 IC50 5.4 nM
Fc1cnc(O[C@H]2C[C@@H](Nc3nc4c(F)cccc4s3)C2)c(C2CCOCC2)c1 CHEMBL3647608 IC50 5.43 nM
Cc1ncc(C)n2nc(CCc3nc(N4CC[C@H](C)C4)nn3C)nc12 CHEMBL3962629 IC50 5.46 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cn2)nc1 CHEMBL4111506 Ki 5.462 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(F)cc(OCC(F)(F)F)cc3n12 CHEMBL1916137 IC50 5.5 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(CC(C)C)ncc1Nc1cncnc1 CHEMBL3685506 IC50 5.5 nM
CCc1ccc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c(C(=O)NC)n1 CHEMBL3685597 IC50 5.5 nM
O=C(Nc1cccnc1C(=O)N1CCC1)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685610 IC50 5.5 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3C[C@H](C)O)nc2n1 CHEMBL3703548 IC50 5.5 nM
Cc1cccc(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)n1 CHEMBL3942277 Ki 5.5 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCC[C@@H]4C)nn3C)nc12 CHEMBL3937677 IC50 5.5 nM
COc1cc2nncc(-c3cnc(N4CCC(O)(c5cccnc5)CC4)c(Cl)c3)c2cc1OC CHEMBL3393199 IC50 5.52 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2nn(C)c(=O)cc2C)nc1 CHEMBL4111836 Ki 5.553 nM
CCn1nc(N2CCCC2)nc1CCc1nc2c(C)ncc(C)n2n1 CHEMBL3952867 IC50 5.57 nM
CC(C)(CO)NC(=O)c1ccncc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3639844 IC50 5.6 nM
CC(C)(C)OC(=O)NC1CN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687038 IC50 5.6 nM
COCc1ncc(Cc2cnc3ccc(O)cc3c2)c2cc(OC)c(OC)cc12 CHEMBL3974291 IC50 5.6 nM
Cc1cn(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C(F)(F)F)n2)nn1 CHEMBL3970642 Ki 5.6 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(-c2ccccc2)nn1CC1CC1 CHEMBL3649554 IC50 5.66 nM
CN(C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1)S(C)(=O)=O CHEMBL3687055 IC50 5.68 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(F)cc(OCC4CC4)cc3n12 CHEMBL1916138 IC50 5.7 nM
CCN(CC(F)F)c1ncc(-c2cnnc3cc(OC)c(OC)cc23)cc1C CHEMBL2070529 IC50 5.7 nM
COc1nc2cccnc2n1-c1ccc(Nc2nc3ccccc3s2)cc1 CHEMBL3287659 IC50 5.7 nM
Cc1cc(C)n2cc(CCc3nc(-c4cncs4)cn3CC(O)c3ccc(Cl)cc3)nc2n1 CHEMBL3639677 IC50 5.7 nM
Cc1cccc2nc(CCc3nc(-c4ccsc4)c[nH]3)nn12 CHEMBL3668922 IC50 5.7 nM
Cc1ccc(C)n2nc(CCc3nc(-c4cccnc4)cn3C)nc12 CHEMBL3668985 IC50 5.7 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(NCc3cnccn3)c(=O)n(C)n2)nc1 CHEMBL4109921 Ki 5.7 nM
COc1ccc(Cn2cc(CNc3cc(OC[C@H]4C[C@@H]4c4ccc(OC)cn4)nn(C)c3=O)c(C)n2)cc1 CHEMBL4114261 Ki 5.7 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cnn(C)c(=O)c2)nc1 CHEMBL4113695 Ki 5.743 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc12 CHEMBL3981364 IC50 5.76 nM
COc1cc2c(cn1)CN(c1ncnn3c(C)nc(-c4ccccc4F)c13)CC2 CHEMBL3691440 IC50 5.77 nM
COc1cc2nncc(-c3ccc(N(C)C(C)C)nc3)c2cc1OC CHEMBL1956222 IC50 5.8 nM
COc1cc2nncc(-c3cnc(N4CCC(O)(c5ccccn5)CC4)c(Cl)c3)c2cc1OC CHEMBL1956247 IC50 5.8 nM
CC1(NC(=O)c2ccncc2NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)COC1 CHEMBL3685544 IC50 5.8 nM
CC1CCCN1C(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689983 IC50 5.8 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2[C@@H]2CCCO2)n1 CHEMBL4115127 Ki 5.8 nM
Cc1nc(C2C[C@H]2c2cn3ccccc3n2)cc(-n2nc(C)nc2C)n1 CHEMBL4112634 Ki 5.8 nM
Cc1nc(N2CC(c3nc4ccccc4[nH]3)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3940312 Ki 5.8 nM
C#CCNc1nc(-n2cncn2)nc(N)c1Br CHEMBL3942498 IC50 5.8 nM
CCO[C@@H](C(=O)c1ccc(-c2cc(OC)c(Cl)c(OC)c2)o1)c1ccc(-c2nnc(C)s2)cc1 CHEMBL4107806 IC50 5.8 nM
CCn1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)nn(C)c2=O)n1 CHEMBL4112087 Ki 5.89 nM
CNC(=O)c1ccc(-c2nccnc2C2CN(c3ncc4ccc(Cl)cc4n3)C2)cc1F CHEMBL3675653 IC50 5.9 nM
COc1ccc(C)n2nc(CCc3c[nH]c(-c4ccccc4)n3)nc12 CHEMBL3681974 IC50 5.9 nM
COc1ccc([C@H]2C[C@@H]2COc2cc(N(Cc3ccc(C)nc3C)Cc3ccc(C)nc3C)c(=O)n(C)n2)nc1 CHEMBL4106859 Ki 5.9 nM
CCn1c(C2CN(c3cc(-n4nc(C)nc4C)nc(C)n3)C2)nc2ccccc21 CHEMBL3974646 Ki 5.9 nM
Cc1cc2c(cn1)CN(c1ncnn3c(C)nc(-c4ccccc4F)c13)CC2 CHEMBL3695544 IC50 5.92 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4nc(C5CC5)ncc4C3)ncnn12 CHEMBL3695554 IC50 5.93 nM
Cn1ccc2cc(-c3nccnc3C3CN(c4ncc5ccccc5n4)C3)ccc21 CHEMBL3687067 IC50 5.95 nM
CCOc1ccccc1-c1ccc(-c2nc3cc(C)ccc3c(N[C@H](C)C(=O)O)c2C#N)cc1 CHEMBL397774 IC50 6.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(N[C@H](C)C(=O)O)c2C#N)cc1 CHEMBL248380 IC50 6.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NC(C)C(=O)O)c2C#N)cc1 CHEMBL246798 IC50 6.0 nM
COc1ccc2nc(C#N)c3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915905 IC50 6.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(NCc3ccccn3)c2c1 CHEMBL1939801 Ki 6.0 nM
O=C(Nc1ccn2cc(-c3ccccc3)nc2n1)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL2180405 IC50 6.0 nM
CC(=O)N(C)c1cccc(-n2ccc(=O)c(-c3ccnn3-c3ccccc3F)n2)c1 CHEMBL2180791 IC50 6.0 nM
Cn1nc(-c2ccccn2)cc1NC(=O)c1nc(C2CCCCC2)ncc1Nc1cncnc1 CHEMBL3642229 IC50 6.0 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)NC2CCCCC2)n1 CHEMBL3685454 IC50 6.0 nM
CN(C)C(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685550 IC50 6.0 nM
CC(C)(O)CNC(=O)c1cccc(F)c1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690021 IC50 6.0 nM
CCOc1cccc2ncc(Cc3c(=O)[nH]c(C)c4cc(OC)c(OC)cc34)cc12 CHEMBL3643848 IC50 6.0 nM
CNc1nc2ccc(OC)cc2cc1Cc1c(=O)[nH]c(C)c2cc(OC)c(OC)cc12 CHEMBL3643857 IC50 6.0 nM
N#Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F CHEMBL3686968 IC50 6.0 nM
OC[C@@H]1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687005 IC50 6.0 nM
OC[C@H]1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687007 IC50 6.0 nM
CC1(C)CN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CCO1 CHEMBL3687039 IC50 6.0 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3CCN3CCOCC3)nc2c1 CHEMBL3703521 IC50 6.0 nM
Oc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3970648 IC50 6.0 nM
Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1 CHEMBL3933143 IC50 6.0 nM
C(=C/c1nc2c(N3CCOCC3)ccnn2c1-c1ccc(Sc2nnc[nH]2)nc1)\c1ccc2ccccc2n1 CHEMBL3966154 IC50 6.0 nM
CS(=O)(=O)NC(=O)Nc1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3977413 IC50 6.0 nM
COc1cc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)ccc1C(=O)O CHEMBL3964465 IC50 6.0 nM
O=C(O)[C@@H]1CCCN1C(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3943736 IC50 6.0 nM
O=C(O)[C@@H]1CCCN1C(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3917087 IC50 6.0 nM
COc1cc2ccccc2nc1/C=C/c1nc2c(N3CCOCC3)ccnn2c1-c1ccc(C(=O)O)cc1 CHEMBL3895234 IC50 6.0 nM
COc1cc(/C=C/c2nc3c(N4CCOCC4)ccnn3c2-c2ccc(C(=O)O)cc2)nc2ccccc12 CHEMBL3939084 IC50 6.0 nM
COc1cccc(-c2c(/C=C/c3ccc4c(C(=O)NS(C)(=O)=O)cccc4n3)nc3c(N4CCOCC4)ccnn23)c1 CHEMBL3926917 IC50 6.0 nM
C(=C/c1nc2c(N3CCOCC3)ccnn2c1-c1ccc(-c2nnn[nH]2)cc1)\c1ccc2ccccc2n1 CHEMBL3985334 IC50 6.0 nM
NCC(=O)N[C@@H](CCCCNC(=O)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1)C(N)=O CHEMBL3910220 IC50 6.0 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2CC2CCCCO2)cc(-n2nc(C)nc2C)n1 CHEMBL4110191 Ki 6.0 nM
Cc1nc([C@@H]2C[C@H]2c2ccc3ccccc3n2)cc(-n2nc(C)nc2C)n1 CHEMBL4109573 Ki 6.0 nM
COc1cc2cncc(Cc3cnc4ccc(O)c(C(F)(F)F)c4c3)c2cc1OC CHEMBL3955765 IC50 6.0 nM
COc1cccc(/C=C/c2cn3c(-c4ccc(C(=O)O)cc4)cnc(N4CCOCC4)c3n2)n1 CHEMBL3914636 IC50 6.0 nM
O=C(O)C1CCN(c2ccc(-c3cnc(N4CCOCC4)c4nc(/C=C/c5ccc6ccccc6n5)cn34)cc2)CC1 CHEMBL3971913 IC50 6.0 nM
O=C1NC(=O)C(c2ccc(-c3cnc(N4CCOCC4)c4nc(CCc5ccc6ccccc6n5)cn34)cc2)O1 CHEMBL3929436 IC50 6.0 nM
c1ccc2nc(OCc3cn4c(-c5ccc(Sc6cnn[nH]6)nc5)cnc(N5CCOCC5)c4n3)ccc2c1 CHEMBL3948193 IC50 6.0 nM
Cc1nc(-c2ccccc2F)c2c(N3CCc4ccc(C5CC5)nc4C3)ncnn12 CHEMBL3691444 IC50 6.03 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cn2)nc1 CHEMBL4110179 Ki 6.037 nM
CCc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686983 IC50 6.09 nM
Cc1cccc(-c2cccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3687087 IC50 6.09 nM
COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 CHEMBL1915910 IC50 6.1 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(C)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3627819 Ki 6.1 nM
CCCc1[nH]c(=O)c(Cc2cnc3ccccc3c2)c2cc(OC)c(OC)cc12 CHEMBL3643893 IC50 6.1 nM
Cc1cccc2nc(CCc3cn4c(n3)-c3ccccc3C4)nn12 CHEMBL3659079 IC50 6.1 nM
COc1cccc(-c2nccnc2C2CN(c3ccc4cc(C)ccc4n3)C2)c1 CHEMBL3691506 IC50 6.1 nM
Clc1cccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)c1 CHEMBL3687058 IC50 6.15 nM
O=C(c1ccc(Oc2ncccc2-c2ccnc(C(F)(F)F)c2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690202 IC50 6.17 nM
Cc1cc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4n3C)cc2)ccn1 CHEMBL3694452 IC50 6.17 nM
COc1cc2nncc(-c3cnc(N4CCC(C(C)(C)O)CC4)c(Cl)c3)c2cc1OC CHEMBL1956252 IC50 6.2 nM
O=C(NC1CC1)c1nocc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685580 IC50 6.2 nM
CCN(C)C(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685615 IC50 6.2 nM
COc1cccc(-c2nccnc2C2CN(c3nc4ccccc4cc3C#N)C2)c1 CHEMBL3691514 IC50 6.2 nM
Cc1nc(N2CC(c3nc4ccccc4n3CCF)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3986987 Ki 6.2 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCCC4)c4ccccc4n3)c(C)c12 CHEMBL3921921 IC50 6.2 nM
Cn1cc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)cn1 CHEMBL3690201 IC50 6.28 nM
COc1ccc2c(c1)nc(CCn1c(=O)n(C)c3cccnc31)n2-c1ccccc1 CHEMBL3288416 IC50 6.3 nM
Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2ncccc21 CHEMBL3315042 IC50 6.3 nM
COc1ccc(-n2c(CCN3C(=O)c4c(Cl)ccc(Cl)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3627818 Ki 6.3 nM
CNC(=O)c1ccc(-c2nccnc2C2CCN(c3ccc4ccc(F)cc4n3)CC2)cc1F CHEMBL3675646 IC50 6.3 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cnn(C)c(=O)c2)nc1 CHEMBL4108243 Ki 6.306 nM
O[C@H]1CC[C@H](c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690344 IC50 6.38 nM
COc1cc2c(cc1OC)-c1c(-c3cccc(N4CCOCC4)c3)ncn1CC2 CHEMBL2017081 Ki 6.4 nM
CC(C)c1ncc(Nc2cncnc2)c(C(=O)Nc2cnccc2C(=O)NCC(C)(C)O)n1 CHEMBL3685515 IC50 6.4 nM
Cc1nc(C)c(CNc2nc(OC[C@H]3C[C@@H]3c3ccccn3)nc(-c3ncco3)c2C)s1 CHEMBL3665956 Ki 6.4 nM
Cc1cccc2nc(CCc3nc(-c4cccs4)cn3[C@@H](C)CO)nn12 CHEMBL3668917 IC50 6.4 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(C(F)(F)F)cc2)[nH]1 CHEMBL3634752 IC50 6.46 nM
OCC1CCN(c2nccnc2OC2CCN(c3ccc4ccccc4n3)CC2)CC1 CHEMBL3356649 IC50 6.5 nM
Cc1ncc(C)n2nc(CCc3c[nH]c(-c4cncs4)n3)nc12 CHEMBL3681981 IC50 6.5 nM
FC(F)(F)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687029 IC50 6.5 nM
COc1cc2cncc(Cc3ccc4nc(C)ccc4c3)c2cc1OC CHEMBL3942119 IC50 6.5 nM
CCCc1ncc(Cc2cnc3ccc(OCC(N)=O)cc3c2)c2cc(OC)c(OC)cc12 CHEMBL3899827 IC50 6.5 nM
O=c1c(/C=C/c2nc3cc(Cl)ccc3n2-c2ccccc2)coc2ccc(F)cc12 CHEMBL5273419 IC50 6.5 nM
O=c1ccc(-c2cccc(OC(F)(F)F)c2)cn1-c1ccnn1-c1ccccc1 CHEMBL5268187 IC50 6.5 nM
COc1ccccc1-c1nc(C)c2nnc3c(OC)cc(F)cc3n12 CHEMBL2070657 IC50 6.53 nM
COCC(=O)N1CCC(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647631 IC50 6.57 nM
COc1cc2c(cc1OC)-c1c(-c3cnc(CN4CCOCC4)s3)ncn1CC2 CHEMBL2017066 Ki 6.6 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC1COC1 CHEMBL3685555 IC50 6.6 nM
CCCc1ncc(Cc2ccc3cccc(OCCO)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3898914 IC50 6.6 nM
Cc1nc(N2CC(c3nc4ccccc4n3CCO)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3957334 Ki 6.6 nM
CC(=O)N1CCN(c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)CC1 CHEMBL3690220 IC50 6.63 nM
CCCn1cc(-c2ccccc2)nc1C1CC1c1nc2c(C)ncc(C)n2n1 CHEMBL3648445 IC50 6.65 nM
FC(F)(F)Oc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686976 IC50 6.65 nM
COCC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3687028 IC50 6.66 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)n(CC4CC4)n3)nc12 CHEMBL3977007 IC50 6.69 nM
Cc1ccc(C)n2nc(CCc3nc(-c4ccccc4)nn3C)nc12 CHEMBL2180415 IC50 6.7 nM
CCCc1nc2cccnc2n1-c1ccc(Nc2ccc(C)cn2)cc1 CHEMBL3287903 IC50 6.7 nM
CCn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC CHEMBL3685553 IC50 6.7 nM
CN(C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(-c3cccnc3)nn2c1)C1CC1 CHEMBL3957978 IC50 6.7 nM
Cc1ncc(C)n2nc(/C=C/c3nc(N4CCCC4)n(C)n3)nc12 CHEMBL3962272 IC50 6.72 nM
CC(=O)N1CC(c2nc(C)c3sc4cc(OCc5ccc6ccccc6n5)ccc4n23)C1 CHEMBL3094139 IC50 6.73 nM
O=C(c1nc2ccccc2[nH]1)N1CC(c2nccnc2N2CCc3ccccc3C2)C1 CHEMBL3682202 IC50 6.76 nM
OCc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 CHEMBL3686975 IC50 6.76 nM
Cc1ncccc1-c1nc(C)c2c(C)nc3ccc(C(F)(F)F)cc3n12 CHEMBL1916109 IC50 6.8 nM
OCC1CCN(c2nc3ccccc3nc2OC2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3356652 IC50 6.8 nM
Nc1ncc2cc(-c3nccnc3OC3CN(c4ccc5ccccc5n4)C3)ccc2n1 CHEMBL3356680 IC50 6.8 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC1CCN(C(=O)OC(C)(C)C)C1 CHEMBL3689968 IC50 6.8 nM
OCC1CCN(c2nccnc2C2CN(c3ncc4cc(Cl)ccc4n3)C2)CC1 CHEMBL3691499 IC50 6.8 nM
Cc1cc(C)n2cc(CCc3nc(-c4cccs4)cn3CCC(C)C)nc2n1 CHEMBL3668909 IC50 6.8 nM
Cc1ccc(-c2cn(C)c(CCc3nc4c(C)ncc(C)n4n3)n2)o1 CHEMBL3668980 IC50 6.8 nM
Cc1nc(C2CC2c2nc3ccccc3[nH]2)cc(-n2nc(C)nc2C)n1 CHEMBL3943128 Ki 6.8 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2-c2ccccc2)n1 CHEMBL3972113 Ki 6.8 nM
Nc1ccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)cc1F CHEMBL3687072 IC50 6.82 nM
C[C@H](Cc1ccccn1)NC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690318 IC50 6.83 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CCCO2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690342 IC50 6.83 nM
Cc1c(C#N)cc(C(F)(F)F)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3944205 IC50 6.84 nM
Cc1nc([C@@]23COC[C@@H]2C3)n2c1sc1cc(OCc3ccc4ccccc4n3)ccc12 CHEMBL3094137 IC50 6.88 nM
COCC(C)NC(=O)c1nn(C)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685467 IC50 6.9 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)N[C@H]1CCOC1 CHEMBL3690008 IC50 6.9 nM
N#Cc1ccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4s3)cc2)cc1 CHEMBL3690205 IC50 6.9 nM
Cc1cnc(CO)c2nc(CCc3cn4c(n3)-c3ccccc3C4)nn12 CHEMBL3659081 IC50 6.9 nM
COc1ccc2c(c1)-c1nc(CCc3nc4c(C)ncc(C)n4n3)cn1C2 CHEMBL3698375 IC50 6.9 nM
Cc1cc(N2CCOCC2)n2nc(CCc3nc(-c4ccccc4)cn3C)nc2n1 CHEMBL3703533 IC50 6.9 nM
Cc1ncc(C)n2nc(CCc3nc(-c4cncs4)cn3C)nc12 CHEMBL3668991 IC50 6.9 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c(-c2cccc3ncccc23)c1 CHEMBL3690229 IC50 6.91 nM
CC1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647640 IC50 6.92 nM
c1ccc2sc(N[C@H]3C[C@@H](Oc4nccnc4N4CCn5cncc5C4)C3)nc2c1 CHEMBL3647646 IC50 6.99 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(N(CC)CC(=O)O)c2C#N)cc1 CHEMBL245984 IC50 7.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(NCC(=O)O)c2C#N)cc1 CHEMBL247973 IC50 7.0 nM
C=Cc1cc(-c2cnnc3cc(OC)c(OC)cc23)cnc1NC(C)C CHEMBL1956242 IC50 7.0 nM
COc1cc(OC(F)F)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2070669 IC50 7.0 nM
O=c1ccn(-c2ccc3ncccc3c2)nc1-c1ccnn1-c1cccc(Cl)c1 CHEMBL2180794 IC50 7.0 nM
CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12 CHEMBL1086110 IC50 7.0 nM
CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12 CHEMBL1085374 IC50 7.0 nM
COCc1ccc(Nc2cncnc2)c(C(=O)Nc2cc(-c3ccccn3)nn2C)n1 CHEMBL3642228 IC50 7.0 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)N2CCCC2)n1 CHEMBL3685448 IC50 7.0 nM
CNC(=O)c1c(NC(=O)c2nc([C@@H]3CCOC3)cnc2Nc2cncnc2)cnn1C CHEMBL3689998 IC50 7.0 nM
N#Cc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccc1F CHEMBL3686969 IC50 7.0 nM
O[C@@H]1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3686999 IC50 7.0 nM
O=C(O)CN1CCC(c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)CC1 CHEMBL3948673 IC50 7.0 nM
NS(=O)(=O)c1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3896000 IC50 7.0 nM
Oc1ncn(-c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2)n1 CHEMBL3972103 IC50 7.0 nM
O=C(O)C1CCN(c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)CC1 CHEMBL3900090 IC50 7.0 nM
O=C(O)c1ccc(-c2c([C@@H]3C[C@H]3c3ccc4ccccc4n3)nc3c(N4CCOCC4)cc(Cl)nn23)cc1 CHEMBL3955884 IC50 7.0 nM
O=C(O)C1CCC(Nc2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)CC1 CHEMBL3962426 IC50 7.0 nM
O=C(O)CC1CCN(c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)CC1 CHEMBL3956294 IC50 7.0 nM
O=C(O)c1ccc(-c2cnc(N3CCOCC3)c3nc([C@H]4C[C@H](c5ccc6ccccc6n5)C4)cn23)cc1 CHEMBL3910121 IC50 7.0 nM
O=C(O)c1ccc(-c2cnc(N3CCOCC3)c3nc(C#Cc4nc5ccccc5s4)cn23)cc1 CHEMBL3918446 IC50 7.0 nM
O=C(O)[C@@H]1CCCN1C(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1 CHEMBL3904263 IC50 7.0 nM
O=C(O)CC(=O)Nc1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1 CHEMBL3967009 IC50 7.0 nM
Oc1nc2ncc(-c3cnc(N4CCOCC4)c4nc(CCc5ccc6ccccc6n5)cn34)cc2[nH]1 CHEMBL3962243 IC50 7.0 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C(F)(F)F)nc2C)n1 CHEMBL3941063 Ki 7.0 nM
Nc1nc(-n2cc(-c3ccccn3)cn2)nc(NCc2cncs2)c1Br CHEMBL3986970 IC50 7.0 nM
Cc1ccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)cc1 CHEMBL3687073 IC50 7.08 nM
COc1cc2c(Cc3cnc4cc(C)ccc4c3)cnc(C)c2cc1OC CHEMBL3947376 IC50 7.1 nM
Cc1nc(N2CC(c3nc4cccc(F)c4n3C)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3985146 Ki 7.1 nM
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@@H](N)C(C)C)cccc4n3)c(C)c12 CHEMBL3929861 IC50 7.1 nM
COc1cc(F)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2070661 IC50 7.2 nM
Cc1cnc(C)n2nc(CCc3nc(-c4ccccc4)cn3C)nc12 CHEMBL2180412 IC50 7.2 nM
COC1CCN(c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1 CHEMBL3086096 IC50 7.2 nM
CN(CCCO)C(=O)c1nn(C)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685464 IC50 7.2 nM
O=C(c1nc2ccccc2[nH]1)N1CC(c2nccnc2N2CCC(CO)CC2)C1 CHEMBL3682196 IC50 7.2 nM
CN(C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(N3CCOCC3)nn2c1)C1CC1 CHEMBL3958035 IC50 7.2 nM
Cn1cc(-c2ccccc2)nc1CCn1nc2cccc(Br)n2c1=O CHEMBL3963747 Ki 7.2 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4s3)cc2)c(-c2ccnc3ccccc23)c1 CHEMBL3690257 IC50 7.22 nM
CC(C)Oc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686986 IC50 7.23 nM
Cc1ccn2nc(CCc3nc(N4CCCC4)n(C)n3)nc2c1C CHEMBL3974909 IC50 7.23 nM
COc1ccc2nc(C(F)F)c3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915904 IC50 7.3 nM
COc1cccc2c1nc(CCn1c(=O)n(C)c3cccnc31)n2-c1ccccc1 CHEMBL3288421 IC50 7.3 nM
Cc1cccc2nc(CCc3nc(-c4ccccc4)cn3CCN(C(C)C)C(C)C)nn12 CHEMBL3703562 IC50 7.3 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)N2CCC(C)(C)C2)n1 CHEMBL3685458 IC50 7.3 nM
CN(C)C(=O)c1nn(-c2ccccn2)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685499 IC50 7.3 nM
COc1ccc2nnc3c(C)nc(-c4cc(OCCC[18F])ccc4F)n3c2n1 CHEMBL5286170 IC50 7.3 nM
COc1ccc2nnc3c(C)nc(-c4cc(OCCCC[18F])ccc4F)n3c2n1 CHEMBL5272525 IC50 7.3 nM
CCCc1nc(C)c2c(C(F)F)nc3ccc(OC)nc3n12 CHEMBL1084713 IC50 7.33 nM
CC(C)(C#N)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686987 IC50 7.37 nM
CC(=O)c1ccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)cc1 CHEMBL3687061 IC50 7.38 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2cc(=O)n(C)cc2C#N)nc1 CHEMBL4111801 Ki 7.392 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 CHEMBL1915888 IC50 7.4 nM
COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)ccc4Cl)n3c2n1 CHEMBL1915891 IC50 7.4 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3ccc(C(F)(F)F)cc3n12 CHEMBL1916108 IC50 7.4 nM
O=C(c1ccc(Oc2nccnc2N2CCCCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3086093 IC50 7.4 nM
N#Cc1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647619 IC50 7.4 nM
Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12 CHEMBL3889554 IC50 7.4 nM
CN(C(=O)c1cnn(C)c1C(=O)NCCc1nc(-c2ccccc2)cn1C)C1CCC1 CHEMBL3649581 IC50 7.41 nM
Cc1nc(C2CCOCC2)n2c1sc1cc(OCc3ccc4ccccc4n3)ccc12 CHEMBL3094145 IC50 7.45 nM
O=C(c1ccc(Oc2ncccc2-c2ccncn2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690235 IC50 7.45 nM
CCOc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccccc3C)n12 CHEMBL1916119 IC50 7.5 nM
COc1cc2nncc(-c3ccc(NCC(C)C)nc3)c2cc1OC CHEMBL1956223 IC50 7.5 nM
CNC(=O)c1ccc(-c2nccnc2C2CCN(c3ccc4cccc(F)c4n3)CC2)cc1F CHEMBL3675648 IC50 7.5 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(N)=O)n1 CHEMBL3685431 IC50 7.5 nM
CN(CCO)C(=O)c1nn(C)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1 CHEMBL3685466 IC50 7.5 nM
CCc1[nH]c(=O)c(Cc2ccc3nc(C)ccc3c2)c2cc(OC)c(OC)cc12 CHEMBL3643900 IC50 7.5 nM
c1ccc2nc(N[C@H]3C[C@@H](Oc4nccnc4C4CCOCC4)C3)ccc2c1 CHEMBL3647664 IC50 7.5 nM
CCc1cccc2nc(CSc3nc(-c4ccccc4)cn3C)nn12 CHEMBL3703541 IC50 7.5 nM
COCC(O)Cn1cc(-c2cccs2)nc1CCc1nc2cccc(C)n2n1 CHEMBL3668918 IC50 7.5 nM
COC1CCN(c2nc3ccc(NC(=O)c4c(C(=O)N5CCCC5)cnn4C)cn3n2)C1 CHEMBL3918632 IC50 7.5 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nc(C)nc2-c2cccnc2)n1 CHEMBL3959432 Ki 7.5 nM
Cc1nc([C@H]2CCCO2)c2c(N3CCc4cnn(C)c4C3)ncnn12 CHEMBL3695565 IC50 7.59 nM
COc1cc2nncc(-c3ccc(NC(C)C)nc3)c2cc1OC CHEMBL1956219 IC50 7.6 nM
CNC(=O)c1ccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)cc1F CHEMBL3675649 IC50 7.6 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)N2CCCCC2)n1 CHEMBL3685444 IC50 7.6 nM
Cc1cc(C)n2cc(CCc3nc(-c4cccs4)c[nH]3)nc2n1 CHEMBL3668900 IC50 7.6 nM
COc1cc2cncc(Cc3ccc4oc5ccccc5c4c3)c2cc1OC CHEMBL3948405 IC50 7.6 nM
CC(=O)c1cccc2c(C)c(C(=O)Nc3ccc4ccccc4n3)sc12 CHEMBL4589996 IC50 7.6 nM
Clc1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)cn1 CHEMBL3647618 IC50 7.66 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(Cl)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3627816 Ki 7.7 nM
Cc1ncc(C)n2nc(CCc3cn(C)c(-c4nccs4)n3)nc12 CHEMBL3681980 IC50 7.7 nM
N#Cc1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3ncc4ccccc4n3)C2)cn1 CHEMBL3647625 IC50 7.71 nM
CN(C)C(=O)c1cc(F)ccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690026 IC50 7.8 nM
CCn1c(=O)oc2ccc(Cc3cncc4cc(OC)c(OC)cc34)cc21 CHEMBL3930383 IC50 7.8 nM
CC(=O)c1ccc(C(C)O)c2c(C)c(C(=O)Nc3cc(C(C)(C)O)c4ccccc4n3)sc12 CHEMBL3984448 IC50 7.8 nM
Cc1cnc(OC[C@H]2C[C@@H]2c2ccccn2)cc1NCc1cnn(C)c1 CHEMBL5410399 Ki 7.8 nM
COc1cc(F)cc2c1nnc1c(C)nc(-c3cccnc3C)n12 CHEMBL2070662 IC50 7.84 nM
COc1ccc2nc(C)c3c(C)nc(-c4cnccc4Cl)n3c2n1 CHEMBL1916093 IC50 7.9 nM
Cc1ccncc1NC(=O)N1CCc2nc(-c3cccnc3)nc(OC(C)C)c2C1 CHEMBL2205202 Ki 7.9 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(C2CC2)ncc1Nc1cncnc1 CHEMBL3685501 IC50 7.9 nM
COCC(O)Cn1cc(-c2cccs2)nc1CCc1cn2c(C)cc(C)nc2n1 CHEMBL3668905 IC50 7.9 nM
COc1cc2cncc(Cc3cnc4ccc(OCC(=O)O)cc4c3)c2cc1OC CHEMBL3952972 IC50 7.9 nM
Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccc2nc(-c3cscn3)nn2c1 CHEMBL3935383 IC50 7.9 nM
C#CCN(Cc1ccc(OC)cc1)c1cc(OC[C@H]2C[C@@H]2c2ccc(OC)cn2)nn(C)c1=O CHEMBL4108375 Ki 7.9 nM
Cc1cc(OC(C)C)cc2c(CN3CCCOCC3)c3c(C)n[nH]c3nc12 CHEMBL1940058 Ki 8.0 nM
N#Cc1c(-c2ccc(-c3ccccc3Cl)cc2)nc2ccncc2c1O CHEMBL1957369 IC50 8.0 nM
CCOc1cccc(-c2ncn3c2-c2cc(OC)c(OC)cc2CC3)c1 CHEMBL2017080 Ki 8.0 nM
Cc1ccc(-c2nc3c(c(OC(C)C)n2)CN(C(=O)Nc2cnccc2C)CC3)cn1 CHEMBL2204544 Ki 8.0 nM
COc1ccc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4n3C)cc2)cc1 CHEMBL3393203 IC50 8.0 nM
Cc1nc2ccc(C(C)C)nc2n2c(-c3cc(O)ccc3F)nnc12 CHEMBL3693267 IC50 8.0 nM
CCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCc2ccccc2)c2cc(OC)c(OC)cc12 CHEMBL3643864 IC50 8.0 nM
O=S(=O)(c1ccccc1)C1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1 CHEMBL3686997 IC50 8.0 nM
COc1cccc(-c2nccnc2C2CN(c3ccc4cnccc4n3)C2)c1 CHEMBL3691511 IC50 8.0 nM
C(=C/c1nc2c(N3CCOCC3)ccnn2c1-c1ccc(Sc2cnn[nH]2)nc1)\c1ccc2ccccc2n1 CHEMBL3939911 IC50 8.0 nM
CS(=O)(=O)Nc1ccc(-c2c(CCc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3962697 IC50 8.0 nM
CS(=O)(=O)NC(=O)Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3948177 IC50 8.0 nM
CC(C)[C@H](NC(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1)C(=O)O CHEMBL3889938 IC50 8.0 nM
CN1C(=O)N(C)S(=O)(=O)c2cc(-c3cnc(N4CCOCC4)c4nc(/C=C/c5ccc6ccccc6n5)cn34)ccc21 CHEMBL3894650 IC50 8.0 nM
Oc1nc2ncc(-c3cnc(N4CCOCC4)c4nc(/C=C/c5ccc6ccccc6n5)cn34)cc2[nH]1 CHEMBL3951489 IC50 8.0 nM
Cc1ccc(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)c(F)n1 CHEMBL3928009 Ki 8.0 nM
Cc1nc(N2CC(c3nc4ccc(F)cc4[nH]3)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3921960 Ki 8.0 nM
C[C@H]1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)C1 CHEMBL3647666 IC50 8.02 nM
Cc1cccn2nc(CCc3nc(-c4ccccc4)cn3CCN3CCOCC3)nc12 CHEMBL3703559 IC50 8.1 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)NCC(O)CO)n1 CHEMBL3685468 IC50 8.1 nM
CN(CC(F)(F)F)C(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3689980 IC50 8.1 nM
Cc1c(Cl)nc(OC[C@H]2C[C@@H]2c2ccc3ncccc3n2)nc1NCc1nc(C)n(C)n1 CHEMBL3665957 Ki 8.1 nM
Cc1cccc2nc(CCc3nc(-c4ccccc4)cn3CCN3CCOCC3)nn12 CHEMBL3703519 IC50 8.1 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(C)c(=O)c2C#N)nc1 CHEMBL4107230 Ki 8.163 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)NCCO)n1 CHEMBL3685465 IC50 8.2 nM
Cn1cc(NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)c(C(=O)N2CCCC2(C)C)n1 CHEMBL3685478 IC50 8.2 nM
CN(C)c1nc2ccc(NC(=O)c3c(C(=O)N4CCC4)cnn3C)cn2n1 CHEMBL3907490 IC50 8.2 nM
Cc1ncc(C)n2nc(CCc3nc(N4CCCC4)n(C4CC4)n3)nc12 CHEMBL3957652 IC50 8.2 nM
CCNc1nc(-n2cc(C(=O)N3CCOCC3)cn2)nc(N)c1Br CHEMBL3935839 IC50 8.2 nM
Cn1ccc([C@H]2C[C@@H]2COc2cc(NCc3nccs3)c(=O)n(C)n2)n1 CHEMBL4107797 Ki 8.21 nM
Cc1cnc(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc12 CHEMBL3954308 IC50 8.21 nM
Cc1ccc(N[C@H]2C[C@@H](Oc3ncccc3C3CCOCC3)C2)nc1 CHEMBL3647592 IC50 8.249 nM
c1ccc2sc(Nc3ccc(Oc4ncncc4C4CCOCC4)cc3)nc2c1 CHEMBL3694453 IC50 8.28 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3ccc(OC(F)(F)F)cc3n12 CHEMBL1916106 IC50 8.3 nM
Cc1ccc2c(c1)nc(CCn1nc(C)c3cccnc31)n2-c1ccccc1 CHEMBL3288413 IC50 8.3 nM
Cc1nc(C)c(CNc2nc(OCC3CC3c3ccncc3)nc(Cl)c2C)s1 CHEMBL3745984 Ki 8.3 nM
COC1CCN(C(=O)c2nn(C)cc2NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)C1 CHEMBL3685474 IC50 8.3 nM
CCc1ncc(Cc2ccc3cccc(NS(C)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3951805 IC50 8.3 nM
Cc1nc([C@@H]2C[C@H]2c2cn3c(C)cccc3n2)cc(-n2nc(C)nc2C)n1 CHEMBL4108686 Ki 8.3 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2cc(CO)cn2)n1 CHEMBL3932062 Ki 8.3 nM
CCCc1nc(C)c2c(C)nc3ccc(C)nc3n12 CHEMBL1086352 IC50 8.32 nM
COc1cc(F)c2nnc3c(C)nc(-c4ccccc4OC)n3c2c1 CHEMBL2070670 IC50 8.33 nM
N#Cc1ccc(-c2nccnc2O[C@H]2C[C@@H](Nc3ccc4ccccc4n3)C2)cn1 CHEMBL3647623 IC50 8.35 nM
Cc1ncc(-c2cc(=O)[nH]cc2C)c(OC[C@H]2C[C@@H]2c2ccccn2)n1 CHEMBL4108705 Ki 8.381 nM
COc1ccc(-n2c(CCN3C(=O)c4cccc(Br)c4C3=O)nc3ccccc3c2=O)cc1 CHEMBL3627842 Ki 8.4 nM
COCC(O)Cn1cc(-c2cccs2)nc1CCc1nc2c(C)cccn2n1 CHEMBL3668963 IC50 8.4 nM
Cc1ncc(C)n2nc(CC(=O)N3c4nc5ccccc5n4C[C@@H]3C)nc12 CHEMBL4459939 IC50 8.4 nM
COc1nc(Cl)c(C)c(NCc2sc(C)nc2C)n1 CHEMBL3622892 Ki 8.5 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(C2CCOC2)ccc1Nc1cncnc1 CHEMBL3685548 IC50 8.5 nM
Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(N)=O CHEMBL3685568 IC50 8.5 nM
O=C(Nc1ccc(C2CC2)nc1C(=O)N1CCC1)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690002 IC50 8.5 nM
Cc1nc(N2CC(c3nc4ccccc4n3C)C2)cc(-n2nncc2C)n1 CHEMBL3924314 Ki 8.5 nM
CCOCCn1c(C2CN(c3cc(-n4nc(C)nc4C)nc(C)n3)C2)nc2ccccc21 CHEMBL3977200 Ki 8.5 nM
Oc1nc(O)c(-c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2)o1 CHEMBL3916260 IC50 8.5 nM
Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2nc3ccccc3cc21 CHEMBL3315039 IC50 8.54 nM
Cc1nc(C)c(CNc2nc(OC[C@@H]3C[C@H]3c3ccccn3)nc(Cl)c2C)s1 CHEMBL3747020 Ki 8.6 nM
FC1(F)CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687031 IC50 8.6 nM
COCc1ncc(Cc2ccc3cccc(N)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3902492 IC50 8.6 nM
Cc1cc(C)n(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)n1 CHEMBL3935613 Ki 8.6 nM
Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nc3ncccc23)cn1 CHEMBL5408604 Ki 8.6 nM
COc1cc2c(cc1OC)-c1c(-c3cnc(C(=O)N(C)C(C)(C)C)s3)ncn1CC2 CHEMBL2017057 Ki 8.7 nM
CN(C(=O)c1nn(C)cc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1)C1CCCC1 CHEMBL3685447 IC50 8.7 nM
Cc1cc(C)n2nc(CCc3nc(-c4ccccc4)cn3CCN(C(C)C)C(C)C)nc2n1 CHEMBL3703546 IC50 8.7 nM
Cc1cc(-c2nc(C)c3sc4cc(OCc5ccc6ccccc6n5)ccc4n23)ccn1 CHEMBL3094142 IC50 8.73 nM
COc1ccc(-c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)nc1 CHEMBL3694431 IC50 8.77 nM
O=C(c1ccc(Oc2ncccc2[C@H]2CCCCO2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690293 IC50 8.79 nM
CNC(=O)c1nn(C)cc1NC(=O)c1nc(C(C)C)ncc1Nc1cncnc1 CHEMBL3685500 IC50 8.8 nM
Cc1cc(C)n2cc(/C=C/c3nc(-c4cccs4)cn3C)nc2n1 CHEMBL3668891 IC50 8.8 nM
Cc1cc(C)n2cc(CCc3nc(-c4cccs4)cn3[C@@H](C)CO)nc2n1 CHEMBL3668904 IC50 8.8 nM
Cc1cccc2nc(CCc3nc(-c4cccs4)cn3C[C@@H](O)CN(C)CC#N)nn12 CHEMBL3668955 IC50 8.8 nM
Cc1cc2nc(CCc3nc4c(C)ncc(C)n4n3)ccc2cc1F CHEMBL3926410 IC50 8.8 nM
C[C@H](CNC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1)c1ccccc1 CHEMBL3690283 IC50 8.81 nM
Cc1nc(C2CCOCC2)c2c(N3CCc4ncccc4C3)ncnn12 CHEMBL3691464 IC50 8.82 nM
Cc1ncc(C)n2nc(CCc3nc(-c4cccnc4)cn3C)nc12 CHEMBL3668986 IC50 8.9 nM
Cn1cc(-c2ccncc2)c(OCCCc2ccc3ccccc3n2)n1 CHEMBL5276744 IC50 8.9 nM
CC1CCN(c2nccnc2C2CN(C(=O)c3nc4ccccc4[nH]3)C2)C1 CHEMBL3682200 IC50 8.92 nM
Cc1ncc(C)n2nc(CCc3nc(N4CC[C@@H](C)C4)nn3C)nc12 CHEMBL4113545 IC50 8.94 nM
CC(=O)N1CCC(c2nc(C)c3sc4cc(OCc5ccc6ccccc6n5)ccc4n23)CC1 CHEMBL3094140 IC50 8.96 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCNC(=O)C3)c2c1 CHEMBL1940051 Ki 9.0 nM
CCc1ccccc1-c1ccc(-c2nc3ccncc3c(O)c2C#N)cc1 CHEMBL1957374 IC50 9.0 nM
O=c1ccn(-c2ccncc2)nc1-c1ccnn1-c1ccnc2ccccc12 CHEMBL2180792 IC50 9.0 nM
COc1cccc2nc(C)c3nnc(-c4ccccc4Cl)n3c12 CHEMBL3092560 IC50 9.0 nM
Cc1nc(C)c(CNc2nc(OCCc3ccccc3)nc(Cl)c2C)s1 CHEMBL3622896 Ki 9.0 nM
COc1ccc(C)n2nc(CCc3cn(C)c(-c4cccs4)n3)nc12 CHEMBL3681979 IC50 9.0 nM
O=C(O)CCC(=O)Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3946980 IC50 9.0 nM
O=C(O)CNC(=O)c1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3986244 IC50 9.0 nM
CC(=O)c1ccc(-c2c(C#Cc3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1 CHEMBL3950046 IC50 9.0 nM
O=c1[nH]nc(-c2ccc(-c3c(/C=C/c4ccc5ccccc5n4)nc4c(N5CCOCC5)ccnn34)cc2F)[nH]1 CHEMBL3901159 IC50 9.0 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2cnc(C)n2)n1 CHEMBL4107456 Ki 9.0 nM
CC(=O)NS(=O)(=O)c1ccc(-c2cnc(N3CCOCC3)c3nc(COc4ccc5ccccc5n4)cn23)cc1 CHEMBL3937948 IC50 9.0 nM
Nc1ccc(-c2cnc(N3CCOCC3)c3nc(CCc4ccc5ccccc5n4)cn23)cc1 CHEMBL3925735 IC50 9.0 nM
O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3cccnc3)n12 CHEMBL3947066 Ki 9.0 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccn3c2I)cc(-n2nc(C)nc2C)n1 CHEMBL4113419 Ki 9.0 nM
CC(=O)c1ccc(-c2cc(N3CC(c4nc5ccccc5n4C)C3)nc(C)n2)nc1 CHEMBL3965650 Ki 9.0 nM
Cc1cnc(C)n2nc(CCc3nc(N4CCC[C@@H]4C)nn3C)nc12 CHEMBL3961806 IC50 9.0 nM
Cc1ccc2c(c1)nc(CCc1nc(C)c3cccnn13)n2-c1ccccc1 CHEMBL3288412 IC50 9.1 nM
CCCn1cc(-c2ccccc2)nc1SCc1cn2c(C)cc(C)nc2n1 CHEMBL3700110 IC50 9.1 nM
COC(C)c1ccc(C(C)=O)c2sc(C(=O)Nc3cc(C(C)(C)O)c4ccccc4n3)c(C)c12 CHEMBL3917899 IC50 9.1 nM
COc1cccc(-c2nc(C)c3nnc4c(OC)cc(F)cc4n23)c1 CHEMBL2070658 IC50 9.11 nM
Fc1ccc(Cn2c(Nc3ccc(Oc4ncccc4C4CCOCC4)cc3)nc3ccccc32)cc1 CHEMBL3694442 IC50 9.12 nM
Cc1ccc2c(c1)nc(CCn1c(=O)n(C)c3cccnc31)n2-c1ccccc1 CHEMBL3288414 IC50 9.2 nM
Cc1nc(C)c(CNc2cc(C3CC3)nc3ccnn23)s1 CHEMBL3695718 Ki 9.2 nM
CC(C)Oc1nc(-c2cccnc2)nc2c1CN(C(=O)Nc1ccc3ccn(C)c3c1)CC2 CHEMBL3659653 Ki 9.2 nM
Cc1cccc2nc(CCc3nc(-c4cccs4)cn3C)nn12 CHEMBL3668964 IC50 9.2 nM
COc1ccc(C)n2nc(CCc3nc(-c4cncs4)cn3C)nc12 CHEMBL3668970 IC50 9.2 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccc(F)cc3[nH]2)cc(-n2nc(C)nc2C)n1 CHEMBL4112484 Ki 9.2 nM
Cc1ncc(-c2ccn(C)c(=O)c2)c(OC[C@H]2C[C@@H]2c2ccc(OC(F)F)cn2)n1 CHEMBL4113651 Ki 9.221 nM
CC(=O)N1CCN(c2nccnc2O[C@H]2C[C@@H](Nc3nc4ccccc4s3)C2)CC1 CHEMBL3647657 IC50 9.26 nM
COc1cccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)c1 CHEMBL3687085 IC50 9.29 nM
O=C(c1nc2ccccc2[nH]1)N1CC(c2nccnc2N2CCC(CCO)CC2)C1 CHEMBL3686889 IC50 9.4 nM
CCCc1ncc(Cc2cnc3ccc(O)cc3c2)c2cc(OC)c(OC)cc12 CHEMBL3913977 IC50 9.4 nM
Cc1cnn(C)c1CNc1cc(OC[C@H]2C[C@@H]2c2ccn(C)n2)nn(C)c1=O CHEMBL4114838 Ki 9.4 nM
Cc1nc(C)n2nc(CCc3nc(N4CCCC4)nn3C)nc2c1Cl CHEMBL3952690 IC50 9.41 nM
COc1cc(F)c2nnc3c(C)nc(-c4sccc4C)n3c2c1 CHEMBL2070671 IC50 9.43 nM
O=C1Cc2cc(-c3nccnc3C3CN(c4ncc5ccccc5n4)C3)ccc2N1 CHEMBL3687069 IC50 9.46 nM
COc1ccnc2c1nc(CCn1c(=O)n(C)c3c(C)ccnc31)n2-c1ccccc1 CHEMBL3288424 IC50 9.5 nM
CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 CHEMBL3965577 IC50 9.5 nM
Cc1nc(N2CC(c3nc4ccccc4n3CCCC#N)C2)cc(-n2nc(C)nc2C)n1 CHEMBL3980148 Ki 9.5 nM
O=C(c1ccc(Oc2ncncc2C2=CCNCC2)cc1)c1nc2ccccc2[nH]1 CHEMBL3690364 IC50 9.58 nM
CS(=O)(=O)Nc1cccc(-c2nccnc2C2CN(c3ncc4ccccc4n3)C2)c1 CHEMBL3687065 IC50 9.59 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(N3CCOC(CO)C3)c2c1 CHEMBL1939793 Ki 9.6 nM
COc1ccc(F)c(-c2nc(C)c3nnc4c(F)cc(OC)cc4n23)c1 CHEMBL2180773 IC50 9.6 nM
CN(CC(C)(C)O)C(=O)c1ncccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3685545 IC50 9.6 nM
Cc1cc(C)n2cc(CCc3nc(-c4cccs4)cn3COCC[Si](C)(C)C)nc2n1 CHEMBL3668899 IC50 9.6 nM
Cc1cccc2nc(CCc3nc(-c4cccnc4)c[nH]3)nn12 CHEMBL3668923 IC50 9.6 nM
Nc1nc(-n2cc(-c3ccc4ccccc4n3)cn2)nc(NC2CCOCC2)c1Br CHEMBL3958266 IC50 9.6 nM
COc1ccc2nc(C#N)c3c(C)nc(C4CCCCC4)n3c2n1 CHEMBL1085311 IC50 9.62 nM
Cc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2nn(C)c(=O)cc2C)nc1 CHEMBL4108990 Ki 9.683 nM
COc1cc2nncc(-c3cnc(NC(C)C)c(F)c3)c2cc1OC CHEMBL1956240 IC50 9.7 nM
CNc1cc(-c2cccnc2Oc2ccc(Nc3nc4ccc(F)c(F)c4[nH]3)cc2)ccn1 CHEMBL3086086 IC50 9.7 nM
CC1(O)CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CC1 CHEMBL3687035 IC50 9.7 nM
CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12 CHEMBL3907941 IC50 9.7 nM
[2H]C([2H])C([2H])([2H])Oc1cn(-c2ccc(C3CCOCC3)cc2F)nc(-c2ccnn2-c2ccccc2)c1=O CHEMBL5266740 IC50 9.7 nM
Cc1c(Cl)cc(C(F)(F)F)c2nc(CCc3nc(N4CCC(F)(F)C4)nn3C)nn12 CHEMBL3930687 IC50 9.78 nM
COc1cc2nncc(-c3cnc(N4CCC(O)(c5ccc(Cl)nc5)CC4)c(C)c3)c2cc1OC CHEMBL3393197 IC50 9.8 nM
CC(C)(O)CNC(=O)c1c(F)cccc1NC(=O)c1nc(C2CC2)cnc1Nc1cncnc1 CHEMBL3690038 IC50 9.8 nM
O=C(c1nc2ccccc2[nH]1)N1CCC(c2nccnc2N2CCC(CO)CC2)CC1 CHEMBL3682152 IC50 9.8 nM
COc1ccc(Cc2nc(C)nn2-c2cc(C3CC3c3nnc(C)s3)nc(C)n2)cc1OC CHEMBL3936818 Ki 9.8 nM
COc1ccc(F)c(-c2nc(C)c3nnc4ccc(OC)nc4n23)c1 CHEMBL2070641 IC50 9.83 nM
COc1ccc([C@H]2C[C@@H]2COc2nc(C)ncc2-c2ccn(CC(=O)O)c(=O)c2)nc1 CHEMBL4110003 Ki 9.852 nM
Cc1ccc([C@H]2C[C@@H]2COc2cc(NCc3nc(C)cs3)c(=O)n(C)n2)nc1 CHEMBL4106974 Ki 9.89 nM
Cc1ccc(C(=O)N2CCc3nc(-c4ccc(Cl)nc4)nc(OC(C)C)c3C2)cn1 CHEMBL3659656 Ki 9.9 nM
Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2Cc2cccnc2)cc(-n2nc(C)nc2C)n1 CHEMBL4112076 Ki 9.9 nM
CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccc2nc(N(CC)CC)nn2c1 CHEMBL3898936 IC50 9.9 nM
CCCc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 CHEMBL3686982 IC50 9.95 nM
CC(C)(Cc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(C(=O)c2nc3ccccc3[nH]2)cc1 CHEMBL3690282 IC50 9.97 nM
Cc1c(Cl)cc(C2CC2)c2nc(CCc3nc(N4CCCC4)nn3C)nn12 CHEMBL3911194 IC50 9.99 nM