O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCCC1 CHEMBL572934 IC50 0.4 nM
CC(C)n1ncc2c(=O)n(Cc3ccccc3)c(N[C@H](C)c3ccc(Cl)cc3)nc21 CHEMBL4639341 IC50 0.9 nM
C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccccc1)c1ccc(Cl)cc1 CHEMBL4640793 IC50 1.5 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 CHEMBL562318 Activity 2.1 nM
C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccccc1)c1ccc(F)cc1 CHEMBL4647278 IC50 2.6 nM
C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc(F)cc1)c1ccc(Cl)cc1 CHEMBL4644729 IC50 2.9 nM
CC(C)c1n[nH]c2c(=O)[nH]c(Cc3cccc(Cl)c3)nc12 CHEMBL512790 IC50 4.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)n1Cc1ccccc1)c1ccc(Cl)cc1 CHEMBL4649493 IC50 4.7 nM
COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC CHEMBL3601563 IC50 7.0 nM
CC1=C(C(=O)O[C@H](C)c2ccccc2)C(c2ccc3c(cnn3C)c2)C(C(=O)O[C@H](C)c2ccccc2)=C(C)N1 CHEMBL5180169 IC50 10.0 nM
O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCOCC1 CHEMBL2179093 IC50 14.0 nM
Cc1ccc(-c2c(C#N)c(=O)n(Cc3ccccc3)c3cc(NC(C)c4ccccn4)ccc23)cc1 CHEMBL5418520 IC50 15.0 nM
N#Cc1c(C2CCCC2)c2ccc(NCc3ccc(F)cn3)cc2n(CC2CCCC2)c1=O CHEMBL5395569 IC50 15.0 nM
C[C@H](Nc1ccc2c(C3CCCC3)c(C#N)c(=O)n(CC3CCCC3)c2c1)c1ccccn1 CHEMBL5419839 IC50 16.0 nM
CC(Nc1ccc2c(C3CCCC3)c(C#N)c(=O)n(CC3CCCC3)c2c1)c1ccccn1 CHEMBL5396782 IC50 19.0 nM
CC(C)n1ncc2c(=O)n(Cc3ccc4c(c3)OCO4)c(N[C@H](C)c3ccc(Cl)cc3)nc21 CHEMBL4639286 IC50 20.0 nM
CC(Nc1ccc2c(C3CCCC3)c(C#N)c(=O)n(Cc3ccccc3)c2c1)c1ccccn1 CHEMBL5396854 IC50 20.0 nM
CC(C)c1c(C#N)c(=O)n(Cc2ccccc2)c2cc(NC(C)c3ccccn3)ccc12 CHEMBL5411664 IC50 22.0 nM
Cc1ccc(-c2c(C#N)c(=O)n(Cc3ccccc3)c3ccc(NC(C)c4ccccn4)cc23)cc1 CHEMBL5415102 IC50 24.0 nM
Cc1ccc(-c2c(C#N)c(=O)n(CC3CCCC3)c3cc(NC(C)c4ccccn4)ccc23)cc1 CHEMBL5413182 IC50 25.0 nM
C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc2c(c1)OCO2)c1ccc(Cl)cc1 CHEMBL4638381 IC50 27.0 nM
COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC CHEMBL4128481 IC50 38.0 nM
C[C@@H](Nc1ccc2c(C3CCCC3)c(C#N)c(=O)n(CC3CCCC3)c2c1)c1ccccn1 CHEMBL5398036 IC50 38.0 nM
Cc1ccc(-c2c(C#N)c(=O)n(Cc3ccccc3)c3ccccc23)cc1 CHEMBL5412461 IC50 48.0 nM
C[C@@H]1CN(Cc2ccc3nccnc3c2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL583914 IC50 50.0 nM
Cc1ccc(-c2c(C#N)c(=O)n(Cc3ccccc3)c3cc(NC(C)c4ccccc4)ccc23)cc1 CHEMBL5425946 IC50 55.0 nM
COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC CHEMBL4127641 IC50 56.0 nM
CC(C)n1ncc2c(=O)n(C)c(N[C@H](C)c3ccc(Cl)cc3)nc21 CHEMBL4642557 IC50 57.0 nM
C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1C)c1ccc(Cl)cc1 CHEMBL4634240 IC50 65.0 nM
C[C@H]1CN(Cc2ccc3nccnc3c2)C[C@@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL565667 pIC50 72.44 nM
CC1=C(C(=O)OCc2ccccc2)C(c2ccc3c(cnn3C)c2)C(C(=O)OCc2ccccc2)=C(C)N1 CHEMBL5183406 IC50 73.0 nM
CC(Nc1ccc2c(C(C)(C)C)c(C#N)c(=O)n(Cc3ccccc3)c2c1)c1ccccn1 CHEMBL5398168 IC50 83.0 nM
CC1=C(C(=O)OCc2cccs2)C(c2ccc3c(cnn3C)c2)C(C(=O)OCc2cccs2)=C(C)N1 CHEMBL5181197 IC50 88.0 nM
Cc1cc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)no1 CHEMBL583064 pIC50 109.65 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL2180072 IC50 116.0 nM
C[C@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccccc1)c1ccc(Cl)cc1 CHEMBL4632429 IC50 157.0 nM
C[C@@H]1CN(Cc2ccc(F)cc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179099 IC50 165.0 nM
CC1=C(C(=O)OCc2ccco2)C(c2ccc3c(cnn3C)c2)C(C(=O)OCc2ccco2)=C(C)N1 CHEMBL5178800 IC50 178.0 nM
CC1=C(C(=O)OCc2cncs2)C(c2ccc3c(cnn3C)c2)C(C(=O)OCc2cncs2)=C(C)N1 CHEMBL5208410 IC50 189.0 nM
C[C@@H]1CN(Cc2ccc(C(F)(F)F)nc2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL574449 IC50 190.0 nM
COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OCc2ccccc2)C1c1ccc2c(cnn2C)c1 CHEMBL5199616 IC50 194.0 nM
Cc1cc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)n(C)n1 CHEMBL575791 pIC50 194.98 nM
Cc1cnc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cn1 CHEMBL575790 pIC50 208.93 nM
CC(Nc1ccc2c(C3CC3)c(C#N)c(=O)n(Cc3ccccc3)c2c1)c1ccccn1 CHEMBL5404961 IC50 218.0 nM
C[C@@H]1CN(Cc2cn3ccccc3n2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL566300 pIC50 218.78 nM
C[C@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccccc1)c1ccc(F)cc1 CHEMBL4636141 IC50 245.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)n1C)c1ccc(Cl)cc1 CHEMBL4632723 IC50 258.0 nM
COc1ccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cn1 CHEMBL575775 pIC50 269.15 nM
CC1=C(C(=O)O[C@@H](C)c2ccccc2)C(c2ccc3c(cnn3C)c2)C(C(=O)O[C@@H](C)c2ccccc2)=C(C)N1 CHEMBL5193756 IC50 285.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL2180071 IC50 297.0 nM
CC1=C(C(=O)OCc2ccccc2)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OCc2ccccc2)=C(C)N1 CHEMBL5176107 IC50 297.0 nM
Cc1ncc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cn1 CHEMBL578033 IC50 400.0 nM
CC[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179096 IC50 431.0 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4877549 IC50 440.0 nM
Cc1ccc(-c2c(C#N)c(=O)[nH]c3ccccc23)cc1 CHEMBL5415663 IC50 450.0 nM
COc1ccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cc1 CHEMBL2179100 IC50 466.0 nM
CC(C)c1n[nH]c2c(=O)[nH]c(Cc3ccccc3OC(F)(F)F)nc12 CHEMBL467282 IC50 520.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ncccn2)C1 CHEMBL2180069 IC50 526.0 nM
Cc1cccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)c1 CHEMBL575745 pIC50 562.34 nM
COc1ccc2c(N[C@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC CHEMBL4129844 IC50 579.0 nM
C[C@@H]1CN(Cc2cccc(F)c2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2177125 IC50 693.0 nM
CCC(CC)n1ncc2c(=O)[nH]c(CC3CCCCC3)nc21 CHEMBL3661035 IC50 720.0 nM
C[C@@H]1CN(Cc2ccccc2F)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179098 IC50 889.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ncccn2)C1 CHEMBL2180070 IC50 900.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCC(Cl)CC1 CHEMBL5077120 IC50 910.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CC2(CC(F)C2)C1 CHEMBL5075032 IC50 960.0 nM
C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccc(F)c(F)c3)nn12 CHEMBL2431822 IC50 963.0 nM
CC(C)c1nn(C)c2c(=O)[nH]c(Cc3ccccc3OCCN3CCOCC3)nc12 CHEMBL466474 IC50 970.0 nM
C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL572747 IC50 970.0 nM
Cc1ccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cn1 CHEMBL2179102 IC50 979.0 nM