COc1ccc(Cc2nc(O)c3c(C)nc([C@@H](CCCc4ccccc4)[C@@H](C)O)n3n2)cc1OC CHEMBL370962 IC50 0.03 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)cc3)nc(C(F)F)c2c(=O)[nH]1 CHEMBL4071033 IC50 0.06 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)c(C)c3)nc(C)c2c(=O)[nH]1 CHEMBL4077126 IC50 0.16 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C4(O)CCCOC4)ccc3Cl)nnc12 CHEMBL3693359 IC50 0.2 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)c(C)c3)nc(CO)c2c(=O)[nH]1 CHEMBL4076642 IC50 0.2 nM
Cc1nn2c(-c3c(C)n[nH]c3-c3ccc(C(F)(F)F)cc3)nc(C(F)F)c2c(=O)[nH]1 CHEMBL4092829 IC50 0.23 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4c(Cl)cccc4Cl)n3c2c1 CHEMBL2313250 IC50 0.28 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CCC3)ncnn12 CHEMBL3655786 IC50 0.3 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)cc3)nc(CO)c2c(=O)[nH]1 CHEMBL4062397 IC50 0.3 nM
Cc1nc2ccc(C(=O)NCc3ccccc3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313258 IC50 0.38 nM
Cc1nc2ccc(C(=O)NCc3ccccn3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313231 IC50 0.42 nM
Cc1nc2ccc(C(=O)NCCN3CCOCC3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313263 IC50 0.47 nM
Cc1ncn(-c2nc3c(C(=O)N[C@@H](c4ccc(OC(F)(F)F)cc4)C(C)(C)O)cnn3cc2C)n1 CHEMBL5268162 IC50 0.51 nM
CCc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)cc1 CHEMBL3655788 IC50 0.517 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC(F)C3)ncnn12 CHEMBL2381188 IC50 0.53 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)c(C)c1 CHEMBL2381186 IC50 0.578 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 CHEMBL2313247 IC50 0.6 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)cc3)nc(C)c2c(=O)[nH]1 CHEMBL4160171 IC50 0.6 nM
C[C@@H]1CCN(C(=O)c2ccc3occc3c2)C[C@H]1c1cc(C(F)F)nc2ncnn12 CHEMBL4794209 IC50 0.6 nM
COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc21)c1ccc(OC(F)(F)F)c(F)c1 CHEMBL4060569 IC50 0.61 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)c(Cl)c1 CHEMBL3655826 IC50 0.761 nM
CNc1ncnn2c(CO)nc(-c3cnn(C)c3-c3ccc(C(F)(F)F)cc3)c12 CHEMBL3655783 IC50 0.763 nM
Cc1cc([C@H]2CCCN(C(=O)c3ccc4ccccc4c3)C2)n2ncnc2n1 CHEMBL4076035 IC50 0.8 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)c(F)c1 CHEMBL2381185 IC50 0.82 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(Cl)cc3)nc(CO)c2c(=O)[nH]1 CHEMBL4073753 IC50 0.92 nM
Cc1nc2c([C@H](C)c3ccc(C(F)(F)F)c(F)c3)nn(CCF)c2c(=O)[nH]1 CHEMBL4863002 Ki 0.92 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2C#N)c2c(N3CCC3)ncnn12 CHEMBL3655823 IC50 0.959 nM
COC(=O)NC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C(F)(F)F)cc4)c23)C1 CHEMBL3655851 IC50 0.975 nM
Cc1nc2ccc(CN3CCOCC3)cc2n2c(-c3c([18F])cccc3Cl)nnc12 CHEMBL3092563 IC50 1.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cn2)c2c(N3CCC3)ncnn12 CHEMBL3092562 IC50 1.0 nM
Cc1nc2ccc(C(C)C)nc2n2c(-c3cc(C4(O)CCC4)ccc3Cl)nnc12 CHEMBL3693348 IC50 1.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(CCC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693326 IC50 1.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC4COCC4O)ccc3Cl)nnc12 CHEMBL3693314 IC50 1.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C4(O)CCC4)ccc3Cl)nnc12 CHEMBL3693345 IC50 1.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(O)ccc3Cl)nnc12 CHEMBL3693268 IC50 1.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C4(O)CCOCC4)ccc3Cl)nnc12 CHEMBL3693351 IC50 1.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2F)c2c(N3CCC3)ncnn12 CHEMBL3655807 IC50 1.0 nM
Cc1cc(C2CCCN(C(=O)c3ccc4ccccc4c3)C2)n2ncnc2n1 CHEMBL4066029 IC50 1.0 nM
Cc1cc(C2CN(C(=O)c3ccc4ccccc4c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4103411 IC50 1.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](C(=O)O)C3)ncnn12 CHEMBL4282336 pIC50 1.0 nM
COc1cc2c(cc1-c1ccccc1)C(c1cccc(C(N)=O)c1)=NCC(=O)N2C CHEMBL3092565 IC50 1.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)F)cc2)c2c(N3CCC3)ncnn12 CHEMBL3655821 IC50 1.01 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Br)cc2)c2c(N3CCC3)ncnn12 CHEMBL3655836 IC50 1.02 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(C(F)(F)F)cc3)nc(C(F)F)c2c(=O)[nH]1 CHEMBL4091870 IC50 1.02 nM
Cc1cc(C(F)(F)F)ccc1-c1c(-c2nn(C)c3ncnc(N(C)C)c23)cnn1C CHEMBL3676227 IC50 1.06 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)c(F)c1F CHEMBL2381187 IC50 1.08 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2F)c2c(N3CC(F)C3)ncnn12 CHEMBL3655849 IC50 1.08 nM
CC1CCN(C(=O)c2ccc3occc3c2)CC1c1cc(C(F)F)nc2ncnn12 CHEMBL4797113 IC50 1.1 nM
Cc1nc2c([C@H](C)c3ccc(C(F)(F)F)c(F)c3)nn(CCO)c2c(=O)[nH]1 CHEMBL4873599 Ki 1.1 nM
Cc1nn2c(-c3c(C)n[nH]c3-c3ccc(C(F)(F)F)cc3)nc(CO)c2c(=O)[nH]1 CHEMBL4059875 IC50 1.12 nM
Cc1nc(-c2cnn(C)c2-c2ccc(OC(F)F)cc2)c2c(N3CCC3)ncnn12 CHEMBL3655837 IC50 1.18 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCO)c3C(=O)NC2)cc1-c1cnc(N2CCCC2)nc1 CHEMBL2387425 IC50 1.2 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(C(F)(F)F)cc3)c12 CHEMBL3655854 IC50 1.25 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC(F)(F)C3)ncnn12 CHEMBL3655787 IC50 1.25 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2)c2c(N3CCC3)ncnn12 CHEMBL3655779 IC50 1.26 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCO)c3C(=O)NC2)cc1-c1cnc(N(C)C)cc1C CHEMBL2387423 IC50 1.3 nM
COc1cc(C(F)(F)F)ccc1-c1c(-c2nc(C)n3ncnc(N4CCC4)c23)cnn1C CHEMBL3655827 IC50 1.3 nM
O=c1[nH]c2ccc(C#Cc3cccnc3)cc2c(OCC2CCNCC2)c1-c1cccs1 CHEMBL3092564 Ki 1.3 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N)ncnn12 CHEMBL4080109 IC50 1.3 nM
C[C@@H]1CCN(c2cc(-c3ccccc3)ccn2)C[C@H]1c1cc(C(F)F)nc2ncnn12 CHEMBL4741218 IC50 1.3 nM
Cc1nc2c([C@H](C)c3ccc(C(C)(C)C)cc3)nn(CCF)c2c(=O)[nH]1 CHEMBL4871796 Ki 1.3 nM
Cc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)cc1 CHEMBL3655778 IC50 1.31 nM
Cc1nc(-c2cnn(C)c2-c2ncc(C(F)(F)F)cc2F)c2c(N3CCC3)ncnn12 CHEMBL3655815 IC50 1.32 nM
CCN(CC)CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 CHEMBL2313261 IC50 1.4 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCO)c3C(=O)NC2)cc1-c1cnc(N2CCOCC2)nc1 CHEMBL2387426 IC50 1.4 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CC[C@H](S(C)(=O)=O)C4)c23)c1-c1ccc(C2CC2)cc1 CHEMBL3676210 IC50 1.43 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)nc1 CHEMBL3655792 IC50 1.47 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(C(F)(F)F)cc1 CHEMBL2381192 IC50 1.48 nM
CS(=O)(=O)n1ccc2cc(C(=O)N3CCC[C@H](c4ccnc5ncnn45)C3)ccc21 CHEMBL4758144 IC50 1.5 nM
CC(=O)N[C@@H]1CCN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(C4CC4)cc2)nn3C)C1 CHEMBL3676206 IC50 1.52 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(C)(F)F)cn2)c2c(N3CCC3)ncnn12 CHEMBL3655844 IC50 1.55 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](NS(C)(=O)=O)C3)ncnn12 CHEMBL4284884 pIC50 1.585 nM
Cc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)cc1Cl CHEMBL3655822 IC50 1.59 nM
COc1ccc(Cc2nn3c([C@@H](CCCc4ccccc4)[C@H](C)O)nc(C)c3c(=O)[nH]2)cc1OC CHEMBL4069753 IC50 1.59 nM
COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4102321 IC50 1.6 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)cc1 CHEMBL3676184 IC50 1.64 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CC(F)C5)c34)cnn2C)c(Cl)c1 CHEMBL3655824 IC50 1.69 nM
Cc1nc2ccc(C(=O)NCCc3ccccc3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313260 IC50 1.7 nM
COc1ccc(C(=O)N2CC[C@@H](C)[C@H](c3cc(C(F)F)nc4ncnn34)C2)cc1OC CHEMBL4754478 IC50 1.7 nM
Cc1nc2ccc(C(=O)NCc3ccccc3)cc2n2c(-c3ccccc3)nnc12 CHEMBL4863742 IC50 1.7 nM
Cc1nc2c([C@H](C)c3ccc(C(F)(F)F)cc3)nn(CCO)c2c(=O)[nH]1 CHEMBL4877091 Ki 1.7 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2F)c2c(N3CC(F)C3)ncnn12 CHEMBL2381190 IC50 1.72 nM
COc1ccc(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCO)c4C(=O)NC3)ccc2OC)c(OC)n1 CHEMBL2387427 IC50 1.8 nM
CC(C)(O)C#Cc1ccc2[nH]c(=O)c(-c3cccs3)c(OCC3CCOCC3)c2c1 CHEMBL3665541 Ki 1.8 nM
Cc1nc2c([C@H](C)c3ccc(C(F)(F)F)cc3)nn(CCF)c2c(=O)[nH]1 CHEMBL4867298 Ki 1.8 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](CC(=O)O)C3)ncnn12 CHEMBL4291777 pIC50 1.995 nM
Cc1nc2ccc(C(C)C)nc2n2c(-c3cc(C4(O)CCC4)ccc3F)nnc12 CHEMBL3693349 IC50 2.0 nM
Cc1nc2ccc(C(C)C)nc2n2c(-c3cc(O)ccc3F)nnc12 CHEMBL3693267 IC50 2.0 nM
Cc1ccc(CCC(C)(C)O)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693325 IC50 2.0 nM
Cc1cc(C2CCCN(C(=O)c3ccc4ncccc4c3)C2)n2ncnc2n1 CHEMBL4087945 IC50 2.0 nM
Cc1cc(C2CN(C(=O)c3ccc(F)c(I)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4059930 IC50 2.0 nM
COc1cc(C(F)(F)F)ccc1-c1c(-c2nc(C)n3ncnc(N4CC(F)C4)c23)cnn1C CHEMBL2381189 IC50 2.01 nM
COc1ccc2nnc3c(C)nc(-c4cc(Cl)ccc4Cl)n3c2n1 CHEMBL2070632 IC50 2.06 nM
COc1cc(-c2cccnc2F)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741841 IC50 2.06 nM
CC(=O)n1ccc2cc(C(=O)N3CCCC(c4ccnc5ncnn45)C3)ccc21 CHEMBL4783572 IC50 2.1 nM
CC(C)c1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)cc1 CHEMBL3676221 IC50 2.16 nM
Cc1nc2ccc(C(=O)NCCN3CCCC3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313262 IC50 2.2 nM
Cc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)c(C#N)c1 CHEMBL3655831 IC50 2.24 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N(C)C)ncnn12 CHEMBL3655847 IC50 2.3 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cn2)c2c(C3CCC3)ncnn12 CHEMBL4208160 IC50 2.3 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)cc1 CHEMBL3655790 IC50 2.33 nM
COc1ccc(Cc2nn3c([C@@H](CCC(O)c4ccccc4)[C@@H](C)O)nc(C)c3c(=O)[nH]2)cc1OC CHEMBL4088306 IC50 2.4 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC(S(=O)(=O)CC5CC5)C4)c23)c1-c1ccc(C2CC2)cc1 CHEMBL3676204 IC50 2.47 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCO)c3C(=O)NC2)cc1-c1cnc(N2CCCCC2)nc1 CHEMBL2387429 IC50 2.5 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCO)c3C(=O)NC2)cc1-c1cnc(N(C)C)nc1 CHEMBL2387428 IC50 2.5 nM
Cn1ccc(C2CN(c3ncnc4c3c(-c3cnn(C)c3-c3ccc(C5CC5)cc3)nn4C)C2)n1 CHEMBL3676207 IC50 2.58 nM
CS(=O)(=O)n1ccc2cc(C(=O)N3CCCC(c4ccnc5ncnn45)C3)ccc21 CHEMBL4788385 IC50 2.6 nM
Cc1nc2c([C@H](C)c3ccc(C(C)(C)C)cc3)nn(CCO)c2c(=O)[nH]1 CHEMBL4878348 Ki 2.6 nM
Cn1ncc(-c2ncn3ncnc(N4CCC4)c23)c1-c1ccc(C(F)(F)F)cc1 CHEMBL3655785 IC50 2.68 nM
CN(C)S(=O)(=O)C1CCN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(C4CC4)cc2)nn3C)C1 CHEMBL3676200 IC50 2.7 nM
Cc1cc(C(F)(F)F)ccc1-c1c(-c2nc(C)n3ncnc(N4CC(F)C4)c23)cnn1C CHEMBL3655848 IC50 2.77 nM
Cc1nc2ccc(CN3CCOCC3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313234 IC50 2.8 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4F)n3c2c1 CHEMBL2313249 IC50 2.8 nM
COCC(NC(=O)N1CC(=O)Nc2cc(OC)cnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4064402 IC50 2.8 nM
COC(=O)NC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(Cl)cc4)c23)C1 CHEMBL3655853 IC50 2.89 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC(S(C)(=O)=O)C4)c23)c1-c1ccc(C2CC2)cc1 CHEMBL3676202 IC50 2.98 nM
COc1ccc(F)c(-c2nc(C)c3nnc4ccc(OC)nc4n23)c1 CHEMBL2070641 IC50 2.99 nM
COc1ncc(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCO)c4C(=O)NC3)ccc2OC)cn1 CHEMBL2387430 IC50 3.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OCCCC(F)(F)F)ccc4Cl)n3c2c1 CHEMBL3092558 IC50 3.0 nM
Cc1nc2ccncc2n2c(-c3cc(COCC(F)(F)F)ccc3Cl)nnc12 CHEMBL3427725 IC50 3.0 nM
Cc1ccc(OC2COCC2O)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693315 IC50 3.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC[C@H](C)O)ccc3Cl)nnc12 CHEMBL3693294 IC50 3.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(CCC(C)(C)O)ccc3F)nnc12 CHEMBL3693323 IC50 3.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(O)ccc3F)nnc12 CHEMBL3693264 IC50 3.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(O)ccc4Cl)n3c2n1 CHEMBL3693261 IC50 3.0 nM
Cc1ccc(O)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693265 IC50 3.0 nM
Cc1ccc(O)cc1-c1nnc2c(C)nc3ccc(C(C)C)nc3n12 CHEMBL3693266 IC50 3.0 nM
Cc1ccc(C2(O)CCOCC2)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693365 IC50 3.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OC5CCOCC5)ccc4Cl)n3c2n1 CHEMBL3693289 IC50 3.0 nM
Cc1cc(C2CCCN(C(=O)c3ccc4c(c3)OCC4)C2)n2ncnc2n1 CHEMBL4087412 IC50 3.0 nM
COc1ccc(C(=O)N2CC(c3cc(C)nc4ncnn34)CC(F)(F)C2)cc1C CHEMBL4093237 IC50 3.0 nM
CCCCOc1ccc(F)c(-c2nc(C)c3nnc4ccc(OCCF)nc4n23)c1 CHEMBL5267226 IC50 3.0 nM
CCCCOc1ccc(F)c(-c2nc(C)c3nnc4ccc(OCC[18F])nc4n23)c1 CHEMBL5284717 IC50 3.0 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC(S(=O)(=O)N(C)C)C5)c34)cnn2C)cc1 CHEMBL3676188 IC50 3.1 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(Cl)cc3)nc(C)c2c(=O)[nH]1 CHEMBL4065163 IC50 3.1 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(F)C5)c34)cnn2C)cc1 CHEMBL3676183 IC50 3.16 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](NC(=O)C4CCC4)C3)ncnn12 CHEMBL4291912 pIC50 3.162 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](NC(=O)C(C)C)C3)ncnn12 CHEMBL4281294 pIC50 3.162 nM
COc1ccc(Cc2nn3c([C@@H](CCC(=O)c4ccccc4)[C@@H](C)O)nc(C)c3c(=O)[nH]2)cc1OC CHEMBL4096948 IC50 3.19 nM
COc1ccc(Cl)c(-c2nc(C)c3nnc4ccc(-c5ccnc(F)c5)cc4n23)c1 CHEMBL5276846 IC50 3.3 nM
COc1ccc(Cl)c(-c2nc(C)c3nnc4ccc(-c5ccnc([18F])c5)cc4n23)c1 CHEMBL5288161 IC50 3.3 nM
COc1ccc2nnc3c(C)nc(-c4cc(Cl)ccc4Cl)n3c2c1 CHEMBL2180771 IC50 3.31 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(OC(F)(F)F)cc3)c12 CHEMBL3655819 IC50 3.34 nM
COc1ccc(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCO)c4C(=O)NC3)ccc2OC)c(OC)c1 CHEMBL2385104 IC50 3.4 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(C2CC2)cc1 CHEMBL3676208 IC50 3.4 nM
O=C(c1cc2c(s1)CCCC2)N1CCCC(c2cc(C(F)F)nc3ncnn23)C1 CHEMBL4755779 IC50 3.4 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(OC)cc3C)c12 CHEMBL3655816 IC50 3.47 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741573 IC50 3.49 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(OC)C5)c34)cnn2C)cc1 CHEMBL3676214 IC50 3.5 nM
COCC(NC(=O)N1CC(=O)Nc2cc(C3CC3)cnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4072982 IC50 3.5 nM
Cc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2ncnc2n1 CHEMBL4742646 IC50 3.5 nM
COCc1nc(-c2c(C)nn(C)c2-c2ccc(C(F)(F)F)cc2)n2nc(C)[nH]c(=O)c12 CHEMBL4080264 IC50 3.54 nM
CN(C)S(=O)(=O)C1CCN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(Cl)c(F)c2)nn3C)C1 CHEMBL3676195 IC50 3.59 nM
COc1ccc(Cc2nn3c([C@@H](CCC(O)c4ccccc4)[C@@H](C)O)nc(C)c3c(=O)[nH]2)cc1O CHEMBL4096035 IC50 3.59 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(NC(=O)OC)C5)c34)cnn2C)cc1 CHEMBL3676192 IC50 3.6 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2C#N)c2c(N3CCC3)ncnn12 CHEMBL3655828 IC50 3.81 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](NC(=O)C4CCOC4)C3)ncnn12 CHEMBL4277377 pIC50 3.981 nM
Cc1nc2ccc(Cl)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL3092557 IC50 4.0 nM
COc1ccc2nnc3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL2070639 IC50 4.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C4(O)CCOC4)ccc3Cl)nnc12 CHEMBL3693357 IC50 4.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC4COCCC4O)ccc3Cl)nnc12 CHEMBL3693374 IC50 4.0 nM
CCCC(O)c1ccc(Cl)c(-c2nnc3c(C)nc4ccc(C)nc4n23)c1 CHEMBL3693318 IC50 4.0 nM
Cc1nc2ccc(C(C)C)nc2n2c(-c3cc(C(C)(C)O)ccc3Cl)nnc12 CHEMBL3693334 IC50 4.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(CC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693340 IC50 4.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OCCCO)ccc4Cl)n3c2n1 CHEMBL3693284 IC50 4.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OCCCOC(F)(F)F)ccc4Cl)n3c2n1 CHEMBL3693291 IC50 4.0 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(CBr)cc1 CHEMBL3676215 IC50 4.2 nM
Cc1nc2ccc(NCc3c(O)cccc3F)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4847449 IC50 4.2 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CC(c5ccno5)C4)c23)c1-c1ccc(C2CC2)cc1 CHEMBL3676203 IC50 4.25 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(C(F)(F)F)cc3C#N)c12 CHEMBL3655829 IC50 4.28 nM
Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC(S(=O)(=O)C6CC6)C5)c34)cnn2C)cc1 CHEMBL3676186 IC50 4.29 nM
Cn1ncc2c(NC3(c4ccc(C(F)(F)F)cc4)CC3)nc(Cl)nc21 CHEMBL4207777 Ki 4.3 nM
Cc1cc(C2CC2)ccc1-c1c(-c2nn(C)c3ncnc(N(C)C)c23)cnn1C CHEMBL3676226 IC50 4.36 nM
COc1cc(N2CCOCC2)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2070656 IC50 4.37 nM
CCOC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 CHEMBL2311556 IC50 4.4 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(c6ccn(C)n6)C5)c34)cnn2C)cc1 CHEMBL3676189 IC50 4.47 nM
CCCCOc1ccc(F)c(-c2nc(C)c3nnc4ccc(OC)nc4n23)c1 CHEMBL5269828 IC50 4.5 nM
COC(=O)NC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C)cc4)c23)C1 CHEMBL3655852 IC50 4.59 nM
COc1ccc(Cc2nn3c([C@@H](CCc4ccccc4)[C@@H](C)O)nc(C)c3c(=O)[nH]2)cc1OO CHEMBL2387143 IC50 4.7 nM
COc1ccc(Cc2nc(=O)c3c(C)nc([C@H](CCCc4ccccc4)[C@@H](C)O)n3[nH]2)cc1OC CHEMBL5268661 IC50 4.7 nM
Cc1nc2ccc(CN3CCOCC3)cc2n2c(-c3cc(OC(C)C)ccc3Cl)nnc12 CHEMBL3331516 IC50 4.8 nM
Cc1nc2ccc(/N=C/c3ccc(F)cc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4870247 IC50 4.8 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC[C@@H](N(C)C)C5)c34)cnn2C)cc1 CHEMBL3676182 IC50 4.9 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(Br)cc3)c12 CHEMBL3655842 IC50 4.91 nM
Cc1nc2ccc(CN3CCC(O)C3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313239 IC50 5.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OCC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693303 IC50 5.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C4(O)CCOCC4)ccc3F)nnc12 CHEMBL3693352 IC50 5.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)F)cn2)c2c(N3CCC3)ncnn12 CHEMBL3655832 IC50 5.0 nM
CS(=O)(=O)c1cc(F)cc2c1c(Sc1ccc(C(F)(F)F)cc1)c1n2CCC[C@H]1CC(=O)O CHEMBL4228478 IC50 5.0 nM
CC(=O)N[C@H]1CCN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C(F)(F)F)cc4)c23)C1 CHEMBL4284700 pIC50 5.012 nM
Cc1cnc2c(C(=O)N[C@@H](c3ccc(OC(F)(F)F)cc3)C(C)(C)O)cnn2c1 CHEMBL5274203 IC50 5.1 nM
CC(=O)N(C)C1CCN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(C4CC4)cc2)nn3C)C1 CHEMBL3676201 IC50 5.14 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(C(F)F)cc1 CHEMBL3676181 IC50 5.25 nM
Cc1nc(-c2cc(Cl)ccc2Cl)n2c1nnc1ccc(Cl)cc12 CHEMBL2180772 IC50 5.31 nM
CN(C)[C@@H]1CCN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(C4CC4)cc2)nn3C)C1 CHEMBL3676199 IC50 5.37 nM
COc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)c(Cl)c1 CHEMBL3676222 IC50 5.39 nM
COc1ccc2nc(C(F)F)c3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915904 IC50 5.4 nM
COC(=O)NC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C(F)(F)F)cn4)c23)C1 CHEMBL3655850 IC50 5.45 nM
Cc1nc(NC2(c3ccc(C(F)(F)F)cc3)CC2)c2cnn(C)c2n1 CHEMBL4212416 Ki 5.49 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)(F)C4)c23)c1-c1ccc(C(F)(F)F)cc1 CHEMBL3676212 IC50 5.55 nM
Cc1nc2ccc(NCc3ccccc3F)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4856412 IC50 5.6 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCCC4)c23)c1-c1ccc(C2CC2)cc1 CHEMBL3676205 IC50 5.63 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)(F)C4)c23)c1-c1ccc(C2CC2)cc1 CHEMBL3676219 IC50 5.89 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4OC)n3c2c1 CHEMBL2313248 IC50 5.9 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(C(F)(F)F)c(C)c3)nc(CO)c2c(=O)[nH]1 CHEMBL4090571 IC50 5.94 nM
Cc1ccc(-c2c(-c3nc(C)n4ncnc(N5CC(F)(F)C5)c34)cnn2C)cc1 CHEMBL3655799 IC50 5.95 nM
COc1cccc2nc(C)c3nnc(-c4ccccc4Cl)n3c12 CHEMBL3092560 IC50 6.0 nM
CCCCOc1ccc(Cl)c(-c2nnc3c(C)nc4ccncc4n23)c1 CHEMBL3427722 IC50 6.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC4CCOCC4)ccc3Cl)nnc12 CHEMBL3693290 IC50 6.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C4(O)CCC4)ccc3F)nnc12 CHEMBL3693341 IC50 6.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C(C)(C)O)ccc3Cl)nnc12 CHEMBL3693342 IC50 6.0 nM
CCOc1ccc(Cl)c(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331514 IC50 6.1 nM
Cc1nc2ccc(NCc3ccc(F)cc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4868630 IC50 6.1 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(C(F)F)cc3)c12 CHEMBL3655781 IC50 6.13 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4)n3c2c1 CHEMBL2313246 IC50 6.2 nM
Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)c(Cl)c1 CHEMBL3676220 IC50 6.27 nM
Cc1nc2ccc(CN3CCCC(O)C3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313242 IC50 6.3 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4cccnc4C)n3c2c1 CHEMBL2313254 IC50 6.3 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Br)cn2)c2c(N3CCC3)ncnn12 CHEMBL3655846 IC50 6.3 nM
Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(c6ccn(C)n6)C5)c34)cnn2C)cc1 CHEMBL3676185 IC50 6.33 nM
COc1ccc(O)c(CNc2ccc3nc(C)c4nnc(-c5ccccc5Cl)n4c3c2)c1 CHEMBL4868095 IC50 6.4 nM
COCc1nc(-c2c(C)nn(C)c2-c2ccc(C(F)(F)F)cc2)n2c1c(=O)[nH]c(C)[n+]2[O-] CHEMBL4084107 IC50 6.42 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)C4)c23)c1-c1ccc(C(F)(F)F)cc1 CHEMBL3676213 IC50 6.44 nM
CCCOc1ccc(Cl)c(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331515 IC50 6.5 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCO)c3C(=O)NC2)cc1-c1cnn(C)c1 CHEMBL2387422 IC50 6.8 nM
CC1CN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)nn3C)C1 CHEMBL3676218 IC50 6.83 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(C(F)(F)F)cc3)nc(C)c2c(=O)[nH]1 CHEMBL4171712 IC50 6.9 nM
COc1ncc(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCCO)c4C(=O)NC3)ccc2OC)c(OC)n1 CHEMBL2387441 IC50 7.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC4COCC4O)ccc3F)nnc12 CHEMBL3693370 IC50 7.0 nM
Cc1ccc(CC(C)(C)O)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693338 IC50 7.0 nM
Cc1nc(-c2cnn(C)c2-c2cnc(C(F)(F)F)cn2)c2c(N3CCC3)ncnn12 CHEMBL3655838 IC50 7.0 nM
COCCCOc1ccc(Cl)c(-c2nnc3c(C)nc4ccc(C)nc4n23)c1 CHEMBL3693288 IC50 7.0 nM
Cc1cc(C2CCCN(C(=O)c3ccc4c(c3)CCC4)C2)n2ncnc2n1 CHEMBL4095099 IC50 7.0 nM
C[C@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@H]2CC(=O)O CHEMBL4229054 IC50 7.0 nM
Cc1nc2c([C@H](C)c3ccc(C(F)(F)F)cc3)nn(CC(F)(F)F)c2c(=O)[nH]1 CHEMBL4857137 Ki 7.0 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC(S(C)(=O)=O)C5)c34)cnn2C)cc1 CHEMBL3676187 IC50 7.08 nM
Cc1nc2ccc(CN3CCN(C)CC3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313236 IC50 7.1 nM
CCCOc1cncc2nnc(-c3cnn(C)c3-c3ccc(CC)cc3)n12 CHEMBL4085594 IC50 7.1 nM
COCC(NC(=O)N1CC(=O)Nc2cc(OC)cnc21)c1ccc(C(F)(F)F)cc1 CHEMBL4067117 IC50 7.2 nM
Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)c(C)c1 CHEMBL3676225 IC50 7.23 nM
Cc1nc2ccc(NC3CCOCC3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313237 IC50 7.3 nM
Cc1nc2ccc(NCc3ccccc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4872433 IC50 7.3 nM
COc1ccc(Cl)c(-c2nc(C(F)(F)F)c3c(C)nc4ccc(OC)nc4n23)c1 CHEMBL1915902 IC50 7.4 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(F)(F)C5)c34)cnn2C)cc1 CHEMBL3676217 IC50 7.43 nM
Cc1nc(-c2cnn(C)c2-c2ccc(F)cc2F)c2c(N3CCC3)ncnn12 CHEMBL3655825 IC50 7.55 nM
Cc1nc2ccc(NCc3ccc(Cl)cc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4859428 IC50 7.6 nM
CCCCOc1ccc(Cl)c(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331517 IC50 7.7 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCCC5)c34)cnn2C)cc1 CHEMBL4101083 IC50 7.8 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(C(F)(F)F)cc3)nc(CO)c2c(=O)[nH]1 CHEMBL4088142 IC50 7.8 nM
COC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C(F)(F)F)cc4)c23)C1 CHEMBL3655805 IC50 7.89 nM
Cc1nc(-c2cnn(C)c2-c2ncc(C(F)(F)F)cc2Cl)c2c(N3CCC3)ncnn12 CHEMBL3655814 IC50 7.89 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](NC(=O)C4CCCO4)C3)ncnn12 CHEMBL4280191 pIC50 7.943 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)C4)c23)c1-c1ccc(C(F)F)cc1 CHEMBL3676228 IC50 7.95 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OCC(C)(C)O)ccc3F)nnc12 CHEMBL3693305 IC50 8.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(C(O)C(C)C)ccc4Cl)n3c2n1 CHEMBL3693378 IC50 8.0 nM
Cc1ccc(OCC(C)(C)O)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693306 IC50 8.0 nM
Cc1cc([C@@H]2CN(C(=O)c3ccc(F)c(Br)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4074744 IC50 8.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cn2)c2c(N3CCC3)ncnn12 CHEMBL3655780 IC50 8.19 nM
COC1CN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)nn3C)C1 CHEMBL3676216 IC50 8.6 nM
COCC(NC(=O)N1CC(=O)Nc2cc(C)cnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4085207 IC50 8.7 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4cncc(OC)c4)n3c2c1 CHEMBL2313257 IC50 8.9 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(C2CC2)cn1 CHEMBL3676211 IC50 8.9 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(C(F)(F)F)cn1 CHEMBL3092561 IC50 8.9 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC4CCOCC4O)ccc3Cl)nnc12 CHEMBL3693375 IC50 9.0 nM
Cc1ccc(OCC(C)(C)O)cc1-c1nnc2c(C)nc3ccc(C(C)C)nc3n12 CHEMBL3693309 IC50 9.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(C4(O)CCCOC4)ccc3Cl)nnc12 CHEMBL3693360 IC50 9.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(O)ccc3Cl)nnc12 CHEMBL3693270 IC50 9.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OCCO)ccc4Cl)n3c2n1 CHEMBL3693285 IC50 9.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OC[C@H](C)O)ccc4Cl)n3c2n1 CHEMBL3693292 IC50 9.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OC[C@@H](C)O)ccc4Cl)n3c2n1 CHEMBL3693293 IC50 9.0 nM
COc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)c(F)c1F CHEMBL3676223 IC50 9.01 nM
Cc1nc2ccc(NCc3cc(F)ccc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4849965 IC50 9.1 nM
Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2)c2c(N3CC(F)(F)C3)ncnn12 CHEMBL3655797 IC50 9.11 nM
Cc1nc2ccc(NCc3cc(Cl)ccc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4873206 IC50 9.2 nM
Cc1nc(-c2cnn(C)c2-c2ncc(Cl)cc2F)c2c(N3CCC3)ncnn12 CHEMBL3655784 IC50 9.21 nM
COc1cc(Cc2nn3c([C@@H](CCC(O)c4ccccc4)[C@@H](C)O)nc(C)c3c(=O)[nH]2)ccc1O CHEMBL4076399 IC50 9.26 nM
COc1ccc(F)c(-c2nc(C)c3nnc4c(F)cc(OC)cc4n23)c1 CHEMBL2180773 IC50 9.3 nM
COc1ncc(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCO)c4C(=O)NC3)ccc2OC)c(OC)n1 CHEMBL2387424 IC50 9.3 nM
COc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(NC(=O)OC(C)(C)C)C5)c34)cnn2C)cc1 CHEMBL3676193 IC50 9.34 nM
COc1ccc(Cc2nn3c([C@@H](CCC(O)c4ccccc4)[C@H](C)O)nc(C)c3c(=O)[nH]2)cc1OC CHEMBL4069911 IC50 9.35 nM
COc1ccc(-c2c(-c3nn(C)c4ncnc(-c5ccn(N)n5)c34)cnn2C)cc1F CHEMBL3676196 IC50 9.47 nM
COc1ccc2nc(C)c3c(C(F)(F)F)nc(-c4cc(Cl)ccc4Cl)n3c2n1 CHEMBL1915899 IC50 9.5 nM
Cc1nc2ccc(CN3CCC(O)CC3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313240 IC50 9.7 nM
CCCOc1cncc2nnc(-c3cnn(C)c3-c3ccc(C(F)(F)F)cc3)n12 CHEMBL4083369 IC50 9.7 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(Cl)cc1Cl CHEMBL3676224 IC50 9.72 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC[C@H](NC(C)=O)C5)c34)cnn2C)cc1 CHEMBL3676191 IC50 9.87 nM
COC(=O)NC1CN(c2ncnc3c2c(-c2cnn(C)c2-c2ccc(C)cc2)nn3C)C1 CHEMBL3676190 IC50 9.89 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC(S(=O)(=O)CC5CC5)C4)c23)c1-c1ccc(Cl)c(F)c1 CHEMBL3676197 IC50 9.89 nM
Cc1nc2ccncc2n2c(-c3cc(COC(C)C)ccc3Cl)nnc12 CHEMBL3425534 IC50 10.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(CC(C)(C)O)ccc3F)nnc12 CHEMBL3693337 IC50 10.0 nM
Cc1ccc(C(C)(C)O)cc1-c1nnc2c(C)nc3ccc(C(C)C)nc3n12 CHEMBL3693335 IC50 10.0 nM
COc1ccc(C(=O)N2CCCC(c3cc(C)nc4ncnn34)C2)cc1C CHEMBL4069050 IC50 10.0 nM
CCCCOc1cncc(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331521 IC50 10.0 nM
COCC(=O)N[C@H]1CCN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C(F)(F)F)cc4)c23)C1 CHEMBL4288099 pIC50 10.0 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC(O)C5)c34)cnn2C)cc1 CHEMBL4635049 IC50 10.0 nM
O=C(c1cc2c(s1)CCCC2)N1CCC[C@H](c2ccnc3ncnn23)C1 CHEMBL4761967 IC50 10.0 nM
N#Cc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2ncnc2n1 CHEMBL4761452 IC50 10.0 nM
COc1ccc(Cl)c(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331513 IC50 10.4 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)cc1F CHEMBL3655793 IC50 10.5 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CC(F)(F)C5)c34)cnn2C)cc1 CHEMBL3655798 IC50 10.6 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(C(F)(F)F)cn3)c12 CHEMBL3655782 IC50 10.7 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3)n12 CHEMBL3742354 IC50 10.9 nM
COc1ccc(-c2c(-c3nc(C)c4c(=O)[nH]c(C)nn34)c(C)nn2C)cn1 CHEMBL4074834 IC50 10.9 nM
COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)ccc4Cl)n3c2n1 CHEMBL1915891 IC50 11.0 nM
Cc1nc2ccc(C(C)C)nc2n2c(-c3cc(OCC(C)(C)O)ccc3F)nnc12 CHEMBL3693310 IC50 11.0 nM
CCC(O)c1ccc(Cl)c(-c2nnc3c(C)nc4ccc(C)nc4n23)c1 CHEMBL3693319 IC50 11.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(OC4COCC4O)ccc3Cl)nnc12 CHEMBL3693371 IC50 11.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC4COCCC4O)ccc3F)nnc12 CHEMBL3693372 IC50 11.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cn2)c2c(N)ncnn12 CHEMBL4081035 IC50 11.0 nM
Cc1nc2ccc(NCc3ccccn3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4858592 IC50 11.0 nM
Cc1nc2ccc(NCc3ccc(Cl)cn3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4868686 IC50 11.0 nM
Cc1nc2ccc(NCc3ccc(F)cc3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4848592 IC50 11.0 nM
Cc1nc2ccc(/N=C/c3ccccc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4866974 IC50 11.0 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)cn3)nc(C)c2c(=O)[nH]1 CHEMBL4077939 IC50 11.2 nM
COc1ccc2nnc3c(C)nc(-c4cc(OCCC[18F])ccc4F)n3c2n1 CHEMBL5286170 IC50 11.4 nM
COc1ccc2nc(C)c3c(C(F)(F)F)nc(-c4cc(F)ccc4Cl)n3c2n1 CHEMBL1915901 IC50 11.5 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915890 IC50 11.6 nM
Cc1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)nc1 CHEMBL3655791 IC50 11.6 nM
COc1ccc2nnc3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1 CHEMBL2070631 IC50 11.8 nM
Cc1nc2ccc(N[C@H]3CC[C@H](O)CC3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313238 IC50 12.0 nM
Cc1ccc(C(C)(C)O)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693332 IC50 12.0 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CC(O)C4)c23)c1-c1ccc(C(F)(F)F)cn1 CHEMBL4086493 IC50 12.0 nM
COc1cncc(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331518 IC50 12.1 nM
COc1ccc2nc(C)c3c(C(F)(F)F)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915898 IC50 13.1 nM
COc1ccc2nnc3c(C)nc(-c4ccc(F)cc4C)n3c2n1 CHEMBL2070633 IC50 13.2 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)c(CO)c3)nc(C)c2c(=O)[nH]1 CHEMBL4075381 IC50 13.4 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3ccc(C(F)(F)F)cc3n12 CHEMBL1916108 IC50 13.6 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(OC)cc3)c12 CHEMBL3655812 IC50 13.6 nM
Cc1cnc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)c(F)c1 CHEMBL3655811 IC50 13.7 nM
CNc1ncnc2c1c(-c1cnn(C)c1-c1ccc(C(F)(F)F)cc1)nn2C CHEMBL3676230 IC50 13.7 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3ccc(Cl)cc3n12 CHEMBL1916103 IC50 14.0 nM
COc1cncc(-c2nc(C)c3nnc4ccc(OC)nc4n23)c1 CHEMBL2070636 IC50 14.0 nM
COc1ccc(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCCO)c4C(=O)NC3)ccc2OC)c(OC)c1 CHEMBL2387436 IC50 14.0 nM
Cc1nc2ccccc2n2c(-c3ccccc3Cl)nnc12 CHEMBL1915969 IC50 14.0 nM
Cc1cc(C2CN(C(=O)c3ccc(F)c(Br)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4081851 IC50 14.0 nM
FC(F)(F)c1ccc(C2(Nc3nc(Cl)nc4[nH]ncc34)CC2)cc1 CHEMBL4216198 Ki 14.3 nM
COc1ccc2nnc3c(C)nc(-c4cncc(C)c4)n3c2n1 CHEMBL2070637 IC50 14.4 nM
Cc1ncccc1-c1nc(C)c2c(C)nc3ccc(C(F)(F)F)cc3n12 CHEMBL1916109 IC50 14.7 nM
COC1CCN(Cc2ccc3nc(C)c4nnc(-c5ccccc5Cl)n4c3c2)CC1 CHEMBL2313241 IC50 15.0 nM
Cc1nc2ccc(CNCc3ccccc3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313235 IC50 15.0 nM
Cc1nc2cccnc2n2c(-c3ccccc3Cl)nnc12 CHEMBL3425540 IC50 15.0 nM
Cc1nc2ccc(NCc3cc(OC(F)(F)F)ccc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4859576 IC50 15.0 nM
Cc1nc2ccc(NCc3cc(Br)ccc3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4857374 IC50 15.0 nM
Cc1nc2c([C@H](C)c3ccc(C(F)(F)F)cc3)n[nH]c2c(=O)[nH]1 CHEMBL4876654 Ki 15.0 nM
COc1ccc2nnc3c(C)nc(-c4ccc(Cl)cc4Cl)n3c2n1 CHEMBL2070640 IC50 15.1 nM
Cc1nc(-c2cnn(C)c2-c2ccc(F)cc2)c2c(N3CCC3)ncnn12 CHEMBL3655830 IC50 15.4 nM
COc1ccc(Cc2nn3c([C@@H](CCC(=O)c4ccccc4)[C@H](C)O)nc(C)c3c(=O)[nH]2)cc1OC CHEMBL4064040 IC50 15.6 nM
COc1ccc2nnc3c(C)nc(-c4ccccc4C)n3c2n1 CHEMBL2070634 IC50 15.8 nM
Cc1nc2cccnc2n2c(-c3cc(O)ccc3Cl)nnc12 CHEMBL3693260 IC50 16.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(OC)c(F)c3F)c12 CHEMBL3655818 IC50 16.9 nM
COc1ccc2nc(C)c3c(C)nc(-c4cccnc4C)n3c2n1 CHEMBL1916090 IC50 17.0 nM
Cc1ccc(C(C)(O)CO)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3693362 IC50 17.0 nM
COCCOc1ccc(Cl)c(-c2nnc3c(C)nc4ccc(C)nc4n23)c1 CHEMBL3693286 IC50 17.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(C)cc3)c12 CHEMBL3655806 IC50 17.3 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)cn3)nc(CO)c2c(=O)[nH]1 CHEMBL4093549 IC50 17.3 nM
Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)cc1 CHEMBL3676178 IC50 17.7 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCCO)c3C(=O)NC2)cc1-c1cnc(N(C)C)cc1C CHEMBL2387440 IC50 18.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(C5(O)CCC5)ccc4Cl)n3c2n1 CHEMBL3693346 IC50 18.0 nM
Cc1nc2cccnc2n2c(-c3cc(C4(O)CCCOC4)ccc3Cl)nnc12 CHEMBL3693358 IC50 18.0 nM
CS(=O)(=O)c1cc(F)cc2c1c(Sc1ccc(C(F)(F)F)cc1)c1n2CC[C@H]1CC(=O)O CHEMBL4224708 IC50 18.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(OC)cc3F)c12 CHEMBL3655817 IC50 18.3 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccncc4Cl)n3c2n1 CHEMBL1916095 IC50 18.4 nM
COc1ccc(-c2c(-c3nc(CO)c4c(=O)[nH]c(C)nn34)c(C)nn2C)cn1 CHEMBL4095982 IC50 18.6 nM
Cc1nc2ccc(C(=O)N(C)Cc3ccccc3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313259 IC50 19.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(CO)ccc4Cl)n3c2n1 CHEMBL3693317 IC50 19.0 nM
COCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4098223 IC50 19.0 nM
COc1ccc2nc(C)c3c(C(F)(F)F)nc(-c4ccccc4C)n3c2n1 CHEMBL1915897 IC50 19.5 nM
Cn1ncc2c(NC3(c4ccc(C(F)(F)F)cc4)CC3)nc(C3CC3)nc21 CHEMBL4215537 Ki 19.6 nM
Cc1nn2c(-c3c(C)nn(C)c3-c3ccc(C(F)(F)F)c(CO)c3)nc(CO)c2c(=O)[nH]1 CHEMBL4066430 IC50 19.7 nM
Cc1nc2ccc(CN(C)C)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313233 IC50 20.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OC5CCC(F)(F)CC5)ccc4Cl)n3c2n1 CHEMBL3693287 IC50 20.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(Cl)cc3F)c12 CHEMBL3655808 IC50 20.1 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4cnccc4C)n3c2c1 CHEMBL2313255 IC50 21.0 nM
CCCOCc1ccc(Cl)c(-c2nnc3c(C)nc4ccncc4n23)c1 CHEMBL3427724 IC50 21.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C(C)(C)O)ccc3F)nnc12 CHEMBL3693333 IC50 21.0 nM
CCC(NC(=O)c1cc(=O)[nH]c2cccnc12)c1ccc(OC(F)(F)F)cc1 CHEMBL4079459 IC50 21.0 nM
COc1cc(F)c2nc(C)c3c(C)nc(-c4cccnc4C)n3c2c1 CHEMBL1916135 IC50 21.6 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(OC(F)F)cc3)c12 CHEMBL3655843 IC50 21.6 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(Cl)cc3C#N)c12 CHEMBL3655835 IC50 21.8 nM
COc1ccc2nc(C)c3c(C)nc(-c4cnccc4OC)n3c2n1 CHEMBL1916097 IC50 21.9 nM
COc1cc(F)c2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2c1 CHEMBL1916139 IC50 22.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC4CCC(F)(F)CC4)ccc3Cl)nnc12 CHEMBL3693280 IC50 22.0 nM
Cc1nc2ccc(NCc3cc(Cl)cc(Cl)c3O)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL4865635 IC50 22.0 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3ccc(OC(F)(F)F)cc3n12 CHEMBL1916106 IC50 23.0 nM
COc1ccc2nnc3c(C)nc(-c4sc(C)nc4C)n3c2n1 CHEMBL2070635 IC50 23.0 nM
CCC(CC)c1nn(CCO)c2c1N=C(c1ccc(OC)c(OC)c1)CNC2=O CHEMBL2387135 IC50 23.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C4(O)CCOCC4O)ccc3F)nnc12 CHEMBL3693368 IC50 23.0 nM
Cc1cc([C@@H]2CN(C(=O)c3ccc(F)c(C4CC4)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4077469 IC50 23.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(Cl)cc3)c12 CHEMBL3655810 IC50 23.4 nM
COc1cc(Br)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741950 IC50 23.9 nM
COc1ccc2nc(C)c3c(C)nc(-c4cnccc4Cl)n3c2n1 CHEMBL1916093 IC50 24.0 nM
Cc1nc2ccc(CN3CCCC(CO)C3)cc2n2c(-c3ccccc3Cl)nnc12 CHEMBL2313243 IC50 24.0 nM
CCNCc1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 CHEMBL2313232 IC50 24.0 nM
CC[C@@H](NC(=O)c1cnn2cc(C)cnc12)c1ccc(OC(F)(F)F)cc1 CHEMBL4059831 IC50 24.0 nM
CC(C)(O)C(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4068452 IC50 24.0 nM
O=C(c1ccc2occc2c1)N1CCCC(c2ccnc3ncnn23)C1 CHEMBL4740457 IC50 24.0 nM
Cc1cc(CN2CCC[C@H](c3cc(C(F)F)nc4ncnn34)C2)cc(Cl)n1 CHEMBL4797527 IC50 24.0 nM
COc1ccccc1CCOc1cncc2nnc(-c3c[nH]nc3-c3ccc(C(F)(F)F)cc3)n12 CHEMBL4080861 IC50 24.4 nM
COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 CHEMBL1915910 IC50 24.6 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3cnc(C(F)(F)F)cn3)c12 CHEMBL3639547 IC50 26.8 nM
Cc1nc2c([C@@H](C)c3ccc(C(F)(F)F)cc3)nn(CCF)c2c(=O)[nH]1 CHEMBL4867001 Ki 26.8 nM
COc1ccc2nc(C)c3c(C)nc(-c4c(C)n[nH]c4C)n3c2n1 CHEMBL1915909 IC50 27.0 nM
Cc1nc2c(C(C)c3ccc(C(F)(F)F)cc3)n[nH]c2c(=O)[nH]1 CHEMBL4853336 Ki 27.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1 CHEMBL1915892 IC50 27.5 nM
CCCOc1cncc2nnc(-c3cnn(C)c3-c3ccc(C)cc3)n12 CHEMBL4070209 IC50 27.7 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4cccnc4OC)n3c2c1 CHEMBL2313256 IC50 28.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC4CCOCC4)ccc3Cl)nnc12 CHEMBL3693279 IC50 28.0 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(Cl)cc3)nc(C)c2c(=O)[nH]1 CHEMBL4100565 IC50 28.0 nM
CCOc1ccc(F)c(-c2nc(C)c3nnc4ccc(OC)nc4n23)c1 CHEMBL2070642 IC50 28.6 nM
Cc1nn2c(-c3c(C(=O)O)nn(C)c3-c3ccc(C(F)(F)F)c(C)c3)nc(C)c2c(=O)[nH]1 CHEMBL4103493 IC50 28.6 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccncc4)n3c2c1 CHEMBL2313253 IC50 29.0 nM
Cc1nc2ccncc2n2c(-c3ccccc3Cl)nnc12 CHEMBL3092559 IC50 29.0 nM
CS(=O)(=O)CC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4097310 IC50 29.0 nM
COc1cc(-c2ccc(F)nc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3)n12 CHEMBL3739783 IC50 29.2 nM
COC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(Br)cc4)c23)C1 CHEMBL3655804 IC50 29.8 nM
COc1ccc2nc(C)c3c(C(F)(F)F)nc(-c4ccc(F)cc4Cl)n3c2n1 CHEMBL1915900 IC50 29.9 nM
COc1ccc2nc(C)c3c(C)nc(-c4sc(C)nc4C)n3c2n1 CHEMBL1915912 IC50 30.0 nM
COc1cc(OC)c2nc(C)c3c(C)nc(-c4cccnc4C)n3c2c1 CHEMBL1916125 IC50 30.0 nM
CCOC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4)n3c2c1 CHEMBL2313245 IC50 30.0 nM
Cc1ccc(C2(O)CCOCC2O)cc1-c1nnc2c(C)nc3ccc(C4CC4)nc3n12 CHEMBL3639922 IC50 30.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(F)cc3)c12 CHEMBL3655820 IC50 30.0 nM
O=C(c1cc2c(s1)CCCC2)N1CCCC(c2cc(C(F)F)nc3ccnn23)C1 CHEMBL4751598 IC50 30.0 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4Cl)n3c2c1 CHEMBL2069321 IC50 30.3 nM
CCCOc1cncc(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331519 IC50 30.5 nM
C[C@H](c1ccc(Cl)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@H]2CC(=O)O CHEMBL4228792 IC50 31.0 nM
Cc1nc(-c2cnn(C)c2-c2ccc(C(F)(F)F)cc2)c2c(N3CC[C@H](N)C3)ncnn12 CHEMBL4283641 pIC50 31.62 nM
COc1ccc2nc(C)c3c(C)nc(-c4cccnc4)n3c2n1 CHEMBL1916089 IC50 32.0 nM
Cc1nc2ccc(C3(C)CC3)nc2n2c(-c3cc(C(C)(C)O)ccc3F)nnc12 CHEMBL3693329 IC50 32.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCC4(O)CCC4)ccc3Cl)nnc12 CHEMBL3693307 IC50 33.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC4COCC4O)ccc3Cl)nnc12 CHEMBL3693313 IC50 33.0 nM
COCC(NC(=O)N1CC(=O)Nc2cc(Cl)cnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4093680 IC50 33.0 nM
COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(-c4ccccn4)c3)c2cc1OC CHEMBL3665542 Ki 34.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OC5CCOC5)ccc4Cl)n3c2n1 CHEMBL3693300 IC50 35.0 nM
COc1ccc2nc(C#N)c3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915905 IC50 35.6 nM
COc1cc(F)c2nnc3c(C)nc(-c4sccc4C)n3c2c1 CHEMBL2070671 IC50 35.9 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(F)cc(OC(F)F)cc3n12 CHEMBL1916136 IC50 36.0 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCCO)c3C(=O)NC2)cc1-c1cnn(C)c1 CHEMBL2387439 IC50 36.0 nM
Cc1ccc(O)cc1-c1nnc2c(C)nc3ccc(C(F)(F)F)nc3n12 CHEMBL3693271 IC50 36.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4cccc(C(N)=O)c4)n3c2n1 CHEMBL1915896 IC50 37.0 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CC(F)(F)C5)c34)cnn2C)cc1F CHEMBL3655794 IC50 37.2 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(OC)c(F)c3)c12 CHEMBL3655809 IC50 37.2 nM
COc1ccc2nc(C)c3c(C)nc(-c4cnccc4C)n3c2n1 CHEMBL1916091 IC50 38.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCC4CCOC4)ccc3Cl)nnc12 CHEMBL3693282 IC50 38.0 nM
CS(=O)(=O)c1cc(F)cc2c1c(Sc1ccc(C(F)(F)F)cc1)c1n2CC[C@@H]1CC(=O)O CHEMBL4226404 IC50 38.0 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4cccnc4)n3c2c1 CHEMBL2313252 IC50 39.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(C4(O)CCOC4)ccc3Cl)nnc12 CHEMBL3693361 IC50 39.0 nM
COc1cncc(-c2nc(C)c3nnc4c(F)cc(OC)cc4n23)c1 CHEMBL2180774 IC50 39.4 nM
CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc21 CHEMBL200906 IC50 40.0 nM
Cc1ccncc1-c1nc(C)c2c(C)nc3ccc(Cl)cc3n12 CHEMBL1916102 IC50 40.0 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCCO)c3C(=O)NC2)cc1-c1ccc(C(=O)O)cc1 CHEMBL2387437 IC50 40.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCCO)ccc3Cl)nnc12 CHEMBL3693274 IC50 40.0 nM
COCC(NC(=O)N1CC(=O)Nc2ccc(C)nc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4082199 IC50 40.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccncc4C)n3c2n1 CHEMBL1916094 IC50 40.6 nM
CS(=O)(=O)c1cc(F)cc2c3c(n(Cc4ccc(C(F)(F)F)cc4)c12)C(CC(=O)O)CCC3 CHEMBL4225707 IC50 41.0 nM
COc1cc(N2CCOCC2)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n12 CHEMBL1916127 IC50 42.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(Cl)cn3)c12 CHEMBL3655834 IC50 42.0 nM
CCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)c(F)c1 CHEMBL4078948 IC50 42.0 nM
CC(O)c1ccc(-c2c(-c3nn(C)c4ncnc(N5CCC5)c34)cnn2C)cc1 CHEMBL4635775 IC50 42.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(C4(O)CCOCC4)ccc3Cl)nnc12 CHEMBL3693353 IC50 43.0 nM
CCC(CC)c1nn(CCCO)c2c1N=C(c1ccccc1)CNC2=O CHEMBL2387139 IC50 44.0 nM
CCC(C)(C)c1nn(CCO)c2c1N=C(c1ccc(-n3ccnc3C)cc1)CNC2=O CHEMBL2387140 IC50 45.0 nM
Cc1nc2cccnc2n2c(-c3cc(CCC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693321 IC50 45.0 nM
COc1ccc(OC)c(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCCO)c4C(=O)NC3)ccc2OC)c1 CHEMBL2387435 IC50 46.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(OC4CCOCC4O)ccc3F)nnc12 CHEMBL3693373 IC50 46.0 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3ccnc(F)c3)n12 CHEMBL3741660 IC50 46.8 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 CHEMBL1915888 IC50 47.0 nM
Cc1nc2ccc(C3CC3)nc2n2c(-c3cc(C(C)(C)CO)ccc3F)nnc12 CHEMBL3693363 IC50 47.0 nM
Cc1cc([C@@H]2CCCN(C(=O)c3ccc4ccccc4c3)C2)n2ncnc2n1 CHEMBL4095653 IC50 47.0 nM
COc1ccc(C(=O)N2CCCC(c3ccnc4ncnn34)C2)cc1OC CHEMBL4744076 IC50 47.0 nM
COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC CHEMBL4128481 IC50 47.6 nM
O=C(c1ccc2c(c1)OCCO2)N1CCC[C@H](c2ccnc3ncnn23)C1 CHEMBL4793775 IC50 49.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(OC4COCC4O)ccc3F)nnc12 CHEMBL3693369 IC50 50.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(OCC(C)(C)O)ccc4Cl)n3c2n1 CHEMBL3693304 IC50 50.0 nM
COc1ccc(C(=O)N2CCC[C@H](c3ccnc4ncnn34)C2)cc1 CHEMBL4763230 IC50 50.0 nM
O=C(c1cc2c(s1)CCCC2)N1CCCC(c2cc(C(F)(F)F)nc3ncnn23)C1 CHEMBL4793092 IC50 50.0 nM
COc1cc(N2CCOCC2)cc2c1nnc1c(C)nc(-c3ccccc3Cl)n12 CHEMBL2070655 IC50 50.4 nM
Cc1cc([C@H]2CN(C(=O)c3ccc(F)c(Br)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4065588 IC50 52.0 nM
Cc1cc(C2CN(C(=O)c3ccc(F)c(Cl)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4082820 IC50 52.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCCCO)ccc3Cl)nnc12 CHEMBL3693272 IC50 53.0 nM
CCC(NC(=O)c1cnn2cc(C)cnc12)c1ccc(OC(F)(F)F)cc1 CHEMBL4088107 IC50 53.0 nM
CCC(CC)c1nn(CCO)c2c1N=C(c1ccc(-n3ccnc3C)cc1)CNC2=O CHEMBL2387021 IC50 54.0 nM
CCCCOc1cncc(-c2nnc3c(C)nc4ccncc4n23)c1 CHEMBL3425539 IC50 54.0 nM
Cc1nc2cc(C(C)C)cnc2n2c(-c3cc(OCC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693312 IC50 58.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCC(C)O)ccc3Cl)nnc12 CHEMBL3693275 IC50 58.0 nM
Cc1cnc2c(c1)nc(C)c1nnc(-c3cc(O)ccc3Cl)n12 CHEMBL3693269 IC50 59.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(C(C)O)ccc4Cl)n3c2n1 CHEMBL3693320 IC50 60.0 nM
CC(=O)c1ccc(-c2c(-c3nc(C)n4ncnc(N5CCC5)c34)cnn2C)nc1 CHEMBL3655833 IC50 60.7 nM
CC(C)c1ccc(Cn2c3c(c4cc(F)cc(S(C)(=O)=O)c42)CCCC3CC(=O)O)cc1 CHEMBL4225177 IC50 61.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4sccc4C)n3c2n1 CHEMBL1915906 IC50 62.0 nM
CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(C#Cc4cccnc4)cc23)CC1 CHEMBL3665538 Ki 62.0 nM
Cc1cc([C@@H]2CN(C(=O)c3cc(C)c(F)c(F)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4062668 IC50 62.0 nM
COCCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4081720 IC50 62.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccccc4OC)n3c2n1 CHEMBL1915893 IC50 64.0 nM
Cc1nc2c([C@@H](C)c3ccc(C(F)(F)F)cc3)nn(CCO)c2c(=O)[nH]1 CHEMBL4873375 Ki 64.7 nM
O=C1CN(C(=O)NC(CO)c2ccc(OC(F)(F)F)cc2)c2ncccc2N1 CHEMBL4089589 IC50 65.0 nM
COc1cc(-c2ccc(F)nc2)cc2c1nc(C)c1c(C)nc(-c3ccncc3)n12 CHEMBL3741781 IC50 65.7 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccccc3C)n12 CHEMBL1916117 IC50 66.0 nM
CCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4064344 IC50 66.0 nM
COc1cc(C(=O)N2CCCC(c3ccnc4ncnn34)C2)cc(OC)c1OC CHEMBL4800314 IC50 66.0 nM
COc1ccc(OC2CN(c3ncnc4c3c(CC(C)C)nn4C)C2)cc1 CHEMBL4095252 IC50 66.6 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ncc(C)cc3F)c12 CHEMBL3655813 IC50 67.2 nM
Cc1cc(CN2CCC[C@H](c3cc(C(F)F)nc4ncnn34)C2)cc(C)n1 CHEMBL4785227 IC50 69.0 nM
COc1ccc(-c2[nH]nc(C)c2-c2nc(CO)c3c(=O)[nH]c(C)nn23)cn1 CHEMBL4103726 IC50 69.2 nM
COc1cc(F)c2nc(C)c3c(C)nc(-c4cnccc4C)n3c2c1 CHEMBL1916133 IC50 70.0 nM
COc1ccc(-c2cc(C3=Nc4c(C(C)(C)C)nn(CCCO)c4C(=O)NC3)ccc2OC)cn1 CHEMBL2387438 IC50 70.0 nM
Cc1nc2c(C(C)c3ccc(C(F)(F)F)cc3)nn(C)c2c(=O)[nH]1 CHEMBL4863811 Ki 70.0 nM
COc1ccc(-c2[nH]nc(C)c2-c2nc(C)c3c(=O)[nH]c(C)nn23)cn1 CHEMBL4085803 IC50 70.1 nM
COc1cc(F)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL1916134 IC50 70.5 nM
COc1cc(OC(F)F)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n12 CHEMBL1916129 IC50 71.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC[C@H](C)O)ccc3Cl)nnc12 CHEMBL3693277 IC50 71.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC4CCOC4)ccc3Cl)nnc12 CHEMBL3693281 IC50 71.0 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CC(OC)C5)c34)cnn2C)cc1 CHEMBL3655801 IC50 71.9 nM
Cn1ncc(-c2nn(C)c3ncnc(NCCC(=O)O)c23)c1-c1ccc(C(F)(F)F)cn1 CHEMBL4099071 IC50 72.0 nM
CCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(C(F)(F)F)cc1 CHEMBL4073981 IC50 72.0 nM
CCCCC(CC)CN1C=NC2C(=O)NC(Cc3ccc(OCc4ccccc4)cc3)=NC21 CHEMBL4580973 IC50 72.0 nM
CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(Br)cc23)CC1 CHEMBL3665536 Ki 73.0 nM
Cc1nc2cccnc2n2c(-c3cc(C4(O)CCC4)ccc3Cl)nnc12 CHEMBL3693344 IC50 74.0 nM
COc1cccc(C(=O)N2CCC[C@H](c3ccnc4ncnn34)C2)c1 CHEMBL4761206 IC50 74.0 nM
Cc1ccccc1-c1nc(C)c2c(C)nc3ccc(F)cc3n12 CHEMBL1916101 IC50 75.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC4CCC(O)C4)ccc3Cl)nnc12 CHEMBL3693299 IC50 77.0 nM
COCC(NC(=O)N1CC(=O)Nc2cc(OC(C)C)cnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4085934 IC50 77.0 nM
COc1cc(-c2cccnc2)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 CHEMBL3741492 IC50 78.6 nM
Cc1cc(C2CCCN(C(=O)c3ccc(F)c(C)c3)C2)n2ncnc2n1 CHEMBL4066638 IC50 80.0 nM
CCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(C2CC2)cc1 CHEMBL4094525 IC50 80.0 nM
COc1cc(OCc2ccccc2)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2180775 IC50 80.6 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(F)cc(OCC4CC4)cc3n12 CHEMBL1916138 IC50 81.0 nM
CCCCC(CC)CN1C=NC2C(=O)NC(Cc3ccc(OC)cc3)=NC21 CHEMBL4591047 IC50 81.0 nM
COc1cc(OC)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL1916124 IC50 83.0 nM
COCC(NC(=O)N1CC(=O)Nc2c(C)ccnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4063592 IC50 85.0 nM
Cc1nc2cccnc2n2c(-c3cc(C4(O)CCOCC4)ccc3Cl)nnc12 CHEMBL3693350 IC50 86.0 nM
Cc1ccc(C2(O)CCOCC2)cc1-c1nnc2c(C)nc3ccc(C(F)(F)F)nc3n12 CHEMBL3693355 IC50 87.0 nM
CS(=O)(=O)n1ccc2cc(C(=O)N3CCC[C@@H](c4ccnc5ncnn45)C3)ccc21 CHEMBL4786145 IC50 87.0 nM
CN1CCN(C(=O)c2cc3c(s2)CCCC3)CC1c1ccnc2ncnn12 CHEMBL4758400 IC50 87.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4cnccc4C)n3c2c1 CHEMBL1916104 IC50 89.0 nM
CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(C)cc3C#N)c12 CHEMBL3655845 IC50 89.6 nM
O=C(c1cc2c(s1)CCCC2)N1CCO[C@H](c2ccnc3ncnn23)C1 CHEMBL4796896 IC50 91.0 nM
COC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(Cl)cc4)c23)C1 CHEMBL3655800 IC50 91.3 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n12 CHEMBL1916114 IC50 92.0 nM
CCC(CC)c1nn(CCCO)c2c1N=C(c1ccc(OC)c(OC)c1)CNC2=O CHEMBL2387138 IC50 93.0 nM
COc1ccc(Cc2nn3c([C@@H](CC(O)C(O)c4ccccc4)[C@@H](C)O)nc(C)c3c(=O)[nH]2)cc1OC CHEMBL4077994 IC50 94.6 nM
COCCOc1ccc(Cl)c(-c2nnc3c(C)nc4ccncc4n23)c1 CHEMBL3427723 IC50 95.0 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4C)n3c2c1 CHEMBL2070649 IC50 95.9 nM
COc1ccc(CN(C)c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(OC(F)F)cc4)c23)cc1 CHEMBL3655840 IC50 96.6 nM
Cc1nc(-c2cnn(C)c2-c2ccc([N+](=O)[O-])cn2)c2c(N3CCC3)ncnn12 CHEMBL3655839 IC50 96.7 nM
CC(C)c1nccn1-c1ccc(C2=Nc3c(C(C)(C)C)nn(CCO)c3C(=O)NC2)cc1 CHEMBL2387142 IC50 97.0 nM
Cn1ncc2c(N3CCCC3c3ccc(C(F)(F)F)cc3)nc(Cl)nc21 CHEMBL4215607 Ki 97.2 nM
Cc1nc2cccnc2n2c(-c3cc(OC[C@@H](C)O)ccc3Cl)nnc12 CHEMBL3693276 IC50 98.0 nM
COc1cc(C#N)cc2c1nc(C)c1c(C)nc(-c3cccnc3F)n12 CHEMBL3741518 IC50 98.6 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(C(C)(C)O)ccc3Cl)nnc12 CHEMBL3693366 IC50 100.0 nM
COc1ccc2nnc3c(C)nc(-c4cc(OC(C)C)ccc4F)n3c2n1 CHEMBL2070643 IC50 101.6 nM
CCC(CC)c1nn(CCO)c2c1N=C(c1ccccc1)CNC2=O CHEMBL2387136 IC50 102.0 nM
COc1cccc2c1nnc1c(C)nc(-c3ccccc3Cl)n12 CHEMBL2070648 IC50 103.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(C5(O)CCC5)ccc4F)n3c2n1 CHEMBL3693347 IC50 103.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(C5(O)CCC5)ccc4C)n3c2n1 CHEMBL3693364 IC50 103.0 nM
CCC(C)(C)c1nn(CCO)c2c1N=C(c1ccc(-n3cc(C)nc3C)cc1)CNC2=O CHEMBL2387141 IC50 105.0 nM
COCCNc1cc(O)c2c(=O)c3c(-c4nccs4)[nH]c(Cc4ccc5c(c4)OCO5)c3oc2c1 CHEMBL4218772 IC50 106.0 nM
COc1ccc2nc(C(F)(F)F)c3c(C)nc(-c4ccccc4Cl)n3c2n1 CHEMBL1915903 IC50 108.0 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n12 CHEMBL1916113 IC50 108.0 nM
COc1ccc(CN(C)c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(Br)cc4)c23)cc1 CHEMBL3655841 IC50 108.0 nM
CCCOc1cncc2nnc(-c3cnn(C)c3-c3ccc(OC)cc3)n12 CHEMBL4099808 IC50 108.5 nM
Cc1nc2cccnc2n2c(-c3cc(OCC4(O)CC4)ccc3Cl)nnc12 CHEMBL3693301 IC50 109.0 nM
Cc1ccc2nc(C)c3nnc(-c4cc(C(C)(C)O)ccc4Cl)n3c2n1 CHEMBL3693328 IC50 109.0 nM
COc1cc(N2CCOCC2)cc2c1nnc1c(C)nc(-c3ccccc3C)n12 CHEMBL2070654 IC50 110.0 nM
COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(C4CCCC4)c3)c2cc1OC CHEMBL3665543 Ki 110.0 nM
CNC(=O)c1ccnc(N2CCC(C)C(c3cc(C(F)F)nc4ncnn34)C2)c1 CHEMBL4798804 IC50 110.0 nM
COc1cc(C(F)(F)F)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n12 CHEMBL1916130 IC50 112.0 nM
COc1ccc(-c2c(-c3nc(C)n4ncnc(N5CC(F)(F)C5)c34)cnn2C)nc1 CHEMBL3655795 IC50 112.0 nM
CCCOc1cncc2nnc(-c3c[nH]nc3-c3ccc(C(F)(F)F)cc3)n12 CHEMBL4098897 IC50 115.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4cccnc4OC)n3c2n1 CHEMBL1916096 IC50 116.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCCCO)ccc3F)nnc12 CHEMBL3693283 IC50 116.0 nM
Cc1nc2cccnc2n2c(-c3cc(O)ccc3F)nnc12 CHEMBL3693263 IC50 120.0 nM
COCCOc1cncc(-c2nnc3c(C)nc4ccc(CN5CCOCC5)cc4n23)c1 CHEMBL3331522 IC50 123.0 nM
Cc1nc2cccnc2n2c(-c3cc(C4(O)CCOC4)ccc3Cl)nnc12 CHEMBL3693331 IC50 125.0 nM
CCNc1ncnc2c1c(-c1cnn(C)c1-c1ccc(C(F)(F)F)cc1)nn2C CHEMBL3676229 IC50 126.0 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(F)cc(OCC(F)(F)F)cc3n12 CHEMBL1916137 IC50 128.0 nM
CCc1ccc(-n2cncc2-c2nn(C)c3ncnc(N4CC[C@@H](N(C)C)C4)c23)cc1 CHEMBL3676180 IC50 131.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C(F)(F)F)n3c2n1 CHEMBL1915889 IC50 135.0 nM
Cc1ccccc1-c1nc(C)c2c(C)nc3c(OC(F)F)cc(F)cc3n12 CHEMBL1916118 IC50 138.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCC4(O)CCC4)ccc3F)nnc12 CHEMBL3693311 IC50 140.0 nM
Cc1cc(N2CCCC(C(=O)Nc3ccc4ccccc4c3)C2)n2ncnc2n1 CHEMBL4074644 IC50 140.0 nM
COc1ccc2nnc3c(C)nc(-c4cnccc4C)n3c2n1 CHEMBL2070638 IC50 142.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC4COCCC4O)ccc3Cl)nnc12 CHEMBL3693316 IC50 143.0 nM
Cc1ccc(C(C)(C)O)cc1-c1nnc2c(C)nc3cc(C(C)C)cnc3n12 CHEMBL3693336 IC50 144.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCCC(C)O)ccc3Cl)nnc12 CHEMBL3693278 IC50 146.0 nM
CC(C)Cc1nn(C)c2ncnc(N3Cc4ccccc4C3)c12 CHEMBL4073717 IC50 146.4 nM
Cc1nc2ccncc2n2c(-c3cc(OC(F)(F)F)ccc3Cl)nnc12 CHEMBL3425536 IC50 150.0 nM
Cn1ncc2c(N3CCCCC3c3ccc(C(F)(F)F)cc3)nc(Cl)nc21 CHEMBL4210651 Ki 152.0 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(F)cc(F)cc3n12 CHEMBL1916111 IC50 153.0 nM
Cc1ccc2nc(C)c3nnc(-c4cccc(O)c4)n3c2n1 CHEMBL3693262 IC50 155.0 nM
C[C@@H]1CCN(c2cc(C(C)(C)C)ccn2)C[C@H]1c1cc(C(F)F)nc2ncnn12 CHEMBL4796661 IC50 155.0 nM
COc1ccccc1-c1cc(C2=Nc3c(C(C)(C)C)nn(CCCO)c3C(=O)NC2)ccc1OC CHEMBL2387434 IC50 156.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693302 IC50 156.0 nM
O=c1[nH]c2ccc(-c3ccncc3)cc2c(OCc2ccccn2)c1-c1cccs1 CHEMBL3665539 Ki 160.0 nM
COc1cc(-c2ccncc2)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 CHEMBL3741207 IC50 162.0 nM
Cc1nc2cccnc2n2c(-c3cc(C(C)(C)O)ccc3Cl)nnc12 CHEMBL3693327 IC50 163.0 nM
COc1cc(OC)c2nc(C)c3c(C)nc(-c4cnccc4C)n3c2c1 CHEMBL1916123 IC50 165.0 nM
COc1ccc(Cc2nn3c([C@@H](C(O)CC(O)c4ccccc4)[C@H](C)O)nc(C)c3c(=O)[nH]2)cc1OC CHEMBL4083117 IC50 168.0 nM
Cc1cc(N2CCCC(C(=O)Nc3ccc4c(c3)CCC4)C2)n2ncnc2n1 CHEMBL1482245 IC50 170.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCC4(C)COC4)ccc3Cl)nnc12 CHEMBL3693296 IC50 171.0 nM
COc1cccc2c1nnc1c(C)nc(-c3ccccc3C)n12 CHEMBL2070647 IC50 172.0 nM
Cc1ccc(CCC(C)(C)O)cc1-c1nnc2c(C)nc3cccnc3n12 CHEMBL3693324 IC50 175.0 nM
Cc1nc2c([C@@H](C)c3ccc(C(F)(F)F)cc3)nn(CC(F)(F)F)c2c(=O)[nH]1 CHEMBL4850240 Ki 178.0 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(C(F)(F)F)c(CO)c3)nc(C)c2c(=O)[nH]1 CHEMBL4094751 IC50 186.0 nM
Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccccc1 CHEMBL4071586 IC50 188.7 nM
Cc1ccc(C2(O)CCC2)cc1-c1nnc2c(C)nc3cccnc3n12 CHEMBL3693330 IC50 189.0 nM
Cc1nc2ncccc2n2c(-c3ccccc3Cl)nnc12 CHEMBL3425541 IC50 190.0 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3c(C)nn(C)c3C)n12 CHEMBL1916116 IC50 194.0 nM
Cc1ccc(OCC2(O)CCC2)cc1-c1nnc2c(C)nc3cccnc3n12 CHEMBL3693308 IC50 194.0 nM
Cn1ncc2c(NC3(c4ccc(C(F)(F)F)cc4)CC3)nc(O)nc21 CHEMBL4202746 Ki 195.0 nM
COc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2ncnc2n1 CHEMBL4746828 IC50 195.0 nM
COc1cc(OC)c2nnc3c(C)nc(-c4cccnc4C)n3c2c1 CHEMBL2070651 IC50 196.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(C4(O)CCOCC4)ccc3F)nnc12 CHEMBL3693354 IC50 199.0 nM
Cc1nc2cccnc2n2c(-c3cc(CC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693339 IC50 199.0 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(C(F)(F)F)cn3)nc(C)c2c(=O)[nH]1 CHEMBL4101283 IC50 199.0 nM
COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(C#N)c3)c2cc1-c1ccccc1 CHEMBL3665537 Ki 200.0 nM
Cc1nc2cccnc2n2c(-c3cc(OCCC(C)(C)O)ccc3Cl)nnc12 CHEMBL3693273 IC50 202.0 nM
COc1ccc(Cc2nn3c([C@@H](CCC(O)c4ccccc4)[C@H](C)O)nc(C)c3c(=O)[nH]2)cc1O CHEMBL4061248 IC50 206.0 nM
Cc1nc2c([C@H](C)c3cccc(C(F)(F)F)c3)nn(CCO)c2c(=O)[nH]1 CHEMBL4859356 Ki 208.0 nM
COc1cc(Cl)ccc1NC(=O)C1CCCN(c2cc(C)nc3ncnn23)C1 CHEMBL4102860 IC50 210.0 nM
CCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1F CHEMBL4071171 IC50 210.0 nM
Cc1nc2cccnc2n2c(-c3cc(CCC(C)(C)O)ccc3F)nnc12 CHEMBL3693322 IC50 214.0 nM
Cc1ccc2nc(C)c3nnc(-c4cccc(OCCCO)c4)n3c2n1 CHEMBL3693295 IC50 219.0 nM
Cc1ccc(O)cc1-c1nnc2c(C)nc3cccnc3n12 CHEMBL3639921 IC50 229.0 nM
O=C(O)CC1CCCc2c1n(Cc1ccc(C(F)(F)F)cc1)c1c(C(F)(F)F)cc(F)cc21 CHEMBL4227300 IC50 233.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4ccccc4OC(F)(F)F)n3c2n1 CHEMBL1915894 IC50 237.0 nM
C[C@@H](Nc1nc(Cl)nc2c1cnn2C)c1ccc(C(F)(F)F)cc1 CHEMBL4212115 Ki 237.0 nM
CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12 CHEMBL1086110 IC50 239.0 nM
CCCOc1cncc2nnc(-c3cnn(C)c3-c3ccc(F)cc3)n12 CHEMBL4072920 IC50 240.8 nM
O=C(C1CC1)N1CCC[C@H](c2ccnc3ncnn23)C1 CHEMBL4746465 IC50 246.0 nM
CCCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1 CHEMBL4059794 IC50 250.0 nM
COC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C)cc4)c23)C1 CHEMBL3655802 IC50 251.0 nM
CC(C)(C)c1nn(CCO)c2c1N=C(c1ccc(F)cc1)CNC2=O CHEMBL2387020 IC50 259.0 nM
COC1CN(c2ncnn3c(C)nc(-c4cnn(C)c4-c4ccc(C)cn4)c23)C1 CHEMBL3655803 IC50 260.0 nM
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccn4)n3c2c1 CHEMBL2313251 IC50 263.0 nM
O=C(c1cc2c(s1)CCCC2)N1CCCCC(c2ccnc3ncnn23)C1 CHEMBL4762723 IC50 263.0 nM
COc1cc(F)cc2c1nnc1c(C)nc(-c3sccc3C)n12 CHEMBL2070664 IC50 269.0 nM
COc1ccc2nc(C)c3c(C)nc(-c4cccn4C)n3c2n1 CHEMBL1915907 IC50 276.0 nM
CCOC(=O)c1ccc2c(c1)nc(C)c1nnc(-c3ccccc3)n12 CHEMBL2313244 IC50 280.0 nM
Cc1ccc(-c2c(-c3nc(C)n4ncnc(N5CC(F)(F)C5)c34)cnn2C)nc1 CHEMBL3655796 IC50 289.0 nM
Cc1nc2c([C@@H](C)c3ccc(C(F)(F)F)cc3)n[nH]c2c(=O)[nH]1 CHEMBL4858230 Ki 293.0 nM
CCCOc1cncc2nnc(-c3c[nH]nc3-c3ccc(C)cc3)n12 CHEMBL4091149 IC50 297.8 nM
COc1ccc2nc(C)c3c(C)nc(-c4cn[nH]c4)n3c2n1 CHEMBL1915908 IC50 299.0 nM
CCOc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccccc3C)n12 CHEMBL1916119 IC50 300.0 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3cnccc3C)n12 CHEMBL1916112 IC50 305.0 nM
Cc1nc2ccncc2n2c(-c3cc(N4CCOCC4)ccc3Cl)nnc12 CHEMBL3425535 IC50 310.0 nM
CC(CCc1ccccc1)N1C=NC2C(=O)NC(Cc3ccccc3)=NC21 CHEMBL4453746 IC50 310.0 nM
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COCc2ccccc2Cl)[C@@H](O)[C@@H]1F CHEMBL4215803 IC50 320.0 nM
Cc1nc(-c2cnn(C)c2-c2ccccc2)c2c(N3CCC3)ncnn12 CHEMBL3655789 IC50 322.0 nM
O=C(c1ccc(C(F)(F)F)cc1)N1CCC[C@H](c2ccnc3ncnn23)C1 CHEMBL4799257 IC50 324.0 nM
Cc1nc2c([C@H](C)c3ccc(C(F)(F)F)cc3)nn(CCC(F)(F)F)c2c(=O)[nH]1 CHEMBL4859231 Ki 324.0 nM
Cc1cnccc1-c1nc(C)c2c(C)nc3c(Cl)cc(C(F)(F)F)cc3n12 CHEMBL1916132 IC50 325.0 nM
CCC(CC)c1nn(CCCO)c2c1N=C(c1ccc(-n3ccnc3C)cc1)CNC2=O CHEMBL2387137 IC50 328.0 nM
O=C(c1ccccc1)N1CCC[C@H](c2ccnc3ncnn23)C1 CHEMBL4777378 IC50 339.0 nM
COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2070666 IC50 346.5 nM
O=c1c2ccccc2oc2c(Cc3ccc4c(c3)OCO4)[nH]c(-c3nccs3)c12 CHEMBL4099219 IC50 362.0 nM
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COCc2ccccc2Br)[C@@H](O)[C@@H]1F CHEMBL4217875 IC50 370.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(OC4COCCC4O)ccc3F)nnc12 CHEMBL3693376 IC50 388.0 nM
COc1ccccc1CCOc1cncc2nnc(CC(C)C)n12 CHEMBL4074798 IC50 389.6 nM
COc1cc(-c2ccc(F)nc2)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 CHEMBL3741850 IC50 395.0 nM
Cc1nc2ccc(CN3CCOCC3)cc2n2c(-c3cncc(OC(C)C)c3)nnc12 CHEMBL3331520 IC50 404.0 nM
Cc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2ccnc2n1 CHEMBL4764226 IC50 407.0 nM
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COCc2ccccc2)[C@@H](O)[C@@H]1F CHEMBL4206935 IC50 410.0 nM
COc1cc(Cl)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL1916131 IC50 411.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC(C)C4CCOCC4)ccc3Cl)nnc12 CHEMBL3693297 IC50 417.0 nM
N#Cc1cc(F)cc2c3c(n(Cc4ccc(C(F)(F)F)cc4)c12)C(CC(=O)O)CCC3 CHEMBL4225978 IC50 422.0 nM
CCc1ccc(-c2c(-c3nn(C)c4ncnc(N5CCOCC5)c34)cnn2C)cc1 CHEMBL4093342 IC50 423.0 nM
CS(=O)(=O)c1cccc2c3c(n(Cc4ccc(Cl)cc4)c12)C(CC(=O)O)CCC3 CHEMBL210471 IC50 431.0 nM
Cc1nc2cccnc2n2c(-c3cc(C4(O)CCC4)ccc3F)nnc12 CHEMBL3693343 IC50 434.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(OC4CCOCC4O)ccc3F)nnc12 CHEMBL3693377 IC50 467.0 nM
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COCc2ccccc2F)[C@@H](O)[C@@H]1F CHEMBL4206994 IC50 470.0 nM
Cc1cccc(Cl)c1-c1nnc2c(C)nc3cnccc3n12 CHEMBL3692712 IC50 471.0 nM
Cc1nn2c(-c3c(CO)nn(C)c3-c3ccc(C(F)(F)F)cn3)nc(CO)c2c(=O)[nH]1 CHEMBL4074575 IC50 473.0 nM
COc1ccc(CC(=O)N2CCC[C@H](c3ccnc4ncnn34)C2)cc1OC CHEMBL4743942 IC50 479.0 nM
CCC(NC(=O)c1cnn2cccnc12)c1ccc(OC(F)(F)F)cc1 CHEMBL4087340 IC50 480.0 nM
COc1cc(-c2ccnc(F)c2)cc2c1nc(C)c1c(C)nc(-c3ccnc(F)c3)n12 CHEMBL3741064 IC50 481.0 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCCO)c3C(=O)NC2)cc1-c1ccc(F)cc1F CHEMBL2387432 IC50 483.0 nM
CCC(NC(=O)c1cnn2cc(C)cnc12)c1ccc(OC)cc1 CHEMBL4104510 IC50 490.0 nM
CCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(N2CCC2)cc1 CHEMBL4084307 IC50 500.0 nM
COc1cc(N2CCOCC2)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n12 CHEMBL1916126 IC50 501.0 nM
Cc1cccc(Cl)c1-c1nnc2c(C)nc3ncccc3n12 CHEMBL3692711 IC50 504.0 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCCO)c3C(=O)NC2)cc1-c1ccccc1SC CHEMBL2387431 IC50 505.0 nM
Cc1nc2c([C@@H](C)c3ccc(C(F)(F)F)cc3)nn(CCC(F)(F)F)c2c(=O)[nH]1 CHEMBL4847004 Ki 521.0 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4C(F)(F)F)n3c2c1 CHEMBL2070650 IC50 522.0 nM
CCOC(C(=O)c1ccc(-c2cc(OC)c(Cl)c(OC)c2)o1)c1ccc(-c2nnc(C)s2)cc1 CHEMBL3964627 IC50 545.0 nM
CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)NCCCCCCO)ccc3OCC)nc12 CHEMBL3401745 IC50 560.0 nM
Cc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2nc(C)nc2n1 CHEMBL4757440 IC50 562.0 nM
CCCOc1cncc2nnc(-c3cnn(C)c3-c3ccccc3)n12 CHEMBL4061541 IC50 566.1 nM
CC(c1cccc2ccccc12)N1C=NC2C(=O)NC(Cc3ccccc3)=NC21 CHEMBL4458207 IC50 570.0 nM
COc1ccc(C2=Nc3c(C(C)(C)C)nn(CCCO)c3C(=O)NC2)cc1-c1ccccc1F CHEMBL2387433 IC50 586.0 nM
COc1cc(OC)c2nnc3c(C)nc(-c4ccncc4C)n3c2c1 CHEMBL2070653 IC50 589.0 nM
N#Cc1ccc(C(=O)N2CCC[C@H](c3ccnc4ncnn34)C2)cc1 CHEMBL4793231 IC50 589.0 nM
CC(C)=C[C@H]1Oc2cc(O)ccc2-c2oc3c4c(cc(O)c3c(=O)c21)OC(C)(C)C=C4 CHEMBL4168752 IC50 590.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(C4(O)CCOC4)ccc3F)nnc12 CHEMBL3693356 IC50 591.0 nM
CCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC)cc1 CHEMBL4072924 IC50 610.0 nM
Cc1ccccc1-c1nc(C)c2c(C)nc3c(OCC(F)(F)F)cc(F)cc3n12 CHEMBL1916120 IC50 619.0 nM
N#Cc1ccccc1COC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@@H](F)[C@@H]1O CHEMBL4212765 IC50 620.0 nM
COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3sc(C)nc3C)n12 CHEMBL1916115 IC50 621.0 nM
Cc1nc2ccc(C(F)(F)F)nc2n2c(-c3cc(C(C)(C)O)ccc3F)nnc12 CHEMBL3693367 IC50 622.0 nM
CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc21 CHEMBL296435 IC50 635.0 nM
CCCCCC[C@@H]([C@@H](C)O)n1cnc2c(N)ncnc21 CHEMBL50378 IC50 635.0 nM
Cn1ncc2c(NC(C)(C)c3ccc(C(F)(F)F)cc3)nc(Cl)nc21 CHEMBL4207234 Ki 642.0 nM
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COCc2ccc(Cl)cc2)[C@@H](O)[C@@H]1F CHEMBL4218153 IC50 670.0 nM
Cc1cc(C2CN(C(=O)c3ccc(F)cc3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4090625 IC50 679.0 nM
COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(-c3cccc(F)c3C)n12 CHEMBL2070668 IC50 722.0 nM
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1F CHEMBL4213652 IC50 740.0 nM
COc1ccc(CN2CCCC(c3cc(C(F)F)nc4ncnn34)C2)cc1OC CHEMBL4776046 IC50 741.0 nM
COc1cc(OC)c2nnc3c(C)nc(-c4cnccc4C)n3c2c1 CHEMBL2070652 IC50 775.0 nM
Cc1nc(-c2cnn3c2CN(CC2CCCC2)CC3)c2c(=O)[nH]cnn12 CHEMBL4069698 IC50 792.0 nM
CCCCCC[C@@H]([C@@H](C)O)n1cnc2c(N)ncnc21 CHEMBL1257094 IC50 800.0 nM
CCC(CC)c1nn(CC)c2c1N=C(c1ccc(C(=O)O)cc1)CNC2=O CHEMBL2387019 IC50 840.0 nM
COc1cc(C(F)(F)F)cc2c1nnc1c(C)nc(-c3cnccc3C)n12 CHEMBL2070667 IC50 864.0 nM
COc1ccccc1-c1nc(C)c2nnc3c(OC)cc(F)cc3n12 CHEMBL2070657 IC50 894.0 nM
O=c1[nH]c2ccc(Br)cc2c(/C=C/c2ccccn2)c1-c1cccs1 CHEMBL3665540 Ki 900.0 nM
COC[C@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc21)c1ccc(OC(F)(F)F)c(F)c1 CHEMBL4082451 IC50 910.0 nM
COc1ccccc1C(=O)N1CCC[C@H](c2ccnc3ncnn23)C1 CHEMBL4758276 IC50 912.0 nM
COc1ccc2nnc3c(C)nc(-c4cc(OCCCC[18F])ccc4F)n3c2n1 CHEMBL5272525 IC50 913.0 nM
Cc1nc2cccnc2n2c(-c3cc(OC4CCC(O)CC4)ccc3Cl)nnc12 CHEMBL3693298 IC50 914.0 nM
COc1cc(F)cc2c1nnc1c2c(-c2ccccc2Cl)nn1C CHEMBL4580449 IC50 923.0 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4877549 IC50 940.0 nM
COc1cc(OC(F)F)cc2c1nnc1c(C)nc(-c3ccncc3C)n12 CHEMBL2070669 IC50 944.0 nM
CCOC(=O)c1sc(Nc2nc(NCc3ccc(S(N)(=O)=O)cc3)c3c(ncn3CC)n2)nc1C CHEMBL100503 IC50 950.0 nM
COc1ccnc2c1nnc1c(C)nc(-c3cccnc3C)n12 CHEMBL2070646 IC50 974.0 nM
COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(C#N)cc23)cc1Cl CHEMBL545712 IC50 984.0 nM
Cc1cc(C2CN(C(=O)c3ccc(F)c(F)c3)CC(F)(F)C2)n2ncnc2n1 CHEMBL4100798 IC50 987.0 nM