Cc1csc(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3cccc(-c4ccc(CN5C[C@@H](C)N[C@@H](C)C5)cc4CN4CCOCC4)c3)CC2)n1 CHEMBL3288029 pIC50 0.01995 nM
Cc1ccc(O)c(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3cccc(-c4ccc(CN5C[C@@H](C)N[C@@H](C)C5)cc4CN4CCOCC4)c3)CC2)c1 CHEMBL3288030 pIC50 0.01995 nM
COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)cc1OC1CCCC1 CHEMBL42126 IC50 0.02 nM
COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CCC4=O)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4566742 pKi 0.06166 nM
CC(C)NC(=O)N(Cc1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL377709 IC50 0.1 nM
CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)Nc3ccccc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 CHEMBL380321 IC50 0.1 nM
CC(C)NC(=O)N(Cc1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL382168 IC50 0.1 nM
Cc1cc(C(=O)N(Cc2cccc(-c3cc(C(C)(C)C#N)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)no1 CHEMBL206968 IC50 0.1 nM
CC(C)Nc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830646 IC50 0.1 nM
CC1(C)CC(=O)N(CC(=O)N2CCC(N3N=C(c4ccc(F)cc4)[C@H]4CC=CC[C@H]4C3=O)CC2)C(=O)C1 CHEMBL4435111 pKi 0.1202 nM
COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CC(C)(C)CC4=O)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4441748 pKi 0.123 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL193240 IC50 0.13 nM
COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CC5(CCCCC5)CC4=O)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4453005 pKi 0.1549 nM
COc1ccc(C2=NN(C3CCN(c4nc(N)nc5ccccc45)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4524402 pKi 0.1549 nM
COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CC(C)(C)CC4=O)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC CHEMBL4441871 pKi 0.1622 nM
COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CC(C)C4=O)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4461456 pKi 0.1698 nM
CC(C)c1cc(-c2cccc(/C=C(\c3ccc(S(C)(=O)=O)cc3)c3nccs3)c2)c2ncccc2c1 CHEMBL196969 IC50 0.19 nM
Cc1noc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)n1 CHEMBL381681 IC50 0.2 nM
Cc1ccc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)nc1 CHEMBL197392 IC50 0.2 nM
O=C(O)Cc1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1 CHEMBL1223687 IC50 0.2 nM
COc1ccc(C2=NN(C3CCN(c4ncnc5ccccc45)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4589927 pKi 0.2239 nM
COc1ccc(C2=NN(C3CCN(c4ncnc5ccsc45)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4592553 pKi 0.2344 nM
CC(C)OC(=O)N(Cc1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL209295 IC50 0.3 nM
CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)c3ccccc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 CHEMBL383225 IC50 0.3 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCOCC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL593656 IC50 0.3 nM
CC1(C)CC(=O)N(CC(=O)N2CCC(N3N=C(c4ccc(OC(F)F)c(OC(F)F)c4)[C@H]4CC=CC[C@H]4C3=O)CC2)C(=O)C1 CHEMBL4530777 pKi 0.302 nM
COc1ccc(C2=NN(C3CCN(c4nccc(N)n4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4444578 pKi 0.3162 nM
COc1ccc(C2=NN(C3CCN(C(=O)CN4C(=O)CC(Cc5ccccc5)C4=O)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4473426 pKi 0.3162 nM
CC(C)(c1cc(-c2cccc(-c3ccc(C4CC4C(=O)O)cc3)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL253083 IC50 0.32 nM
O=C(NCC1CC1)c1cn(-c2cccc(-c3ccc(C4CC4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801156 IC50 0.35 nM
COc1ccc(C2=NN(C3CCN(c4nc(N)nc5sccc45)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4460623 pKi 0.3548 nM
Cc1ccc(O)c(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3ccc(F)c(F)c3)CC2)c1 CHEMBL3113734 IC50 0.38 nM
COc1ccc(C2=NN(C3CN(C(=O)CN4C(=O)CC(C)(C)CC4=O)C3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4591859 pKi 0.389 nM
CCOc1cc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CN[C@@](CO)(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)s2)ccc1OC CHEMBL5417689 pIC50 0.3981 nM
[O-][n+]1cccc(C[C@@H](c2ccc(OC(F)F)c(OC3CC3)c2)c2cnc(C(O)(C(F)(F)F)C(F)(F)F)s2)c1 CHEMBL199015 IC50 0.4 nM
COc1ccc(C2=NN(C/C=C/Cn3ccnc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL594108 IC50 0.4 nM
COC(=O)Cc1ccc(OCc2cc(-c3cccc(OC)c3)c3ncccc3c2)cc1 CHEMBL1224717 IC50 0.4 nM
CC(C)Nc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830643 IC50 0.4 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3ccc([C@H]4C[C@@H]4C(=O)O)c(F)c3)c2)c2ncccc2c1=O CHEMBL1801161 IC50 0.46 nM
CC(C)NC(=O)/C(=C\c1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL198853 IC50 0.5 nM
CC(C)c1cc(-c2cccc(/C=C(/C(=O)O)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 CHEMBL197386 IC50 0.5 nM
CC(C)c1cc(-c2cccc(/C=C(/c3ccc(C(C)(C)O)cc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 CHEMBL198674 IC50 0.5 nM
CC(c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)N(C(=O)c1ccc(C(C)(C)O)cc1)c1ccc(S(C)(=O)=O)cc1 CHEMBL380933 IC50 0.5 nM
CC(C)(C#N)c1cc(-c2cccc(CN(Cc3ccc(F)cc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 CHEMBL378681 IC50 0.5 nM
CC(C)Nc1nc2oc3c(NCc4cccnc4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1828652 IC50 0.5 nM
CC(=O)Nc1cccc(-c2ccn(C(Cc3cc[n+]([O-])cc3)c3ccc(OC(F)F)c(OCC4CC4)c3)n2)c1 CHEMBL4534321 IC50 0.5 nM
[11CH3]n1cc(Cc2ccc(OCF)c(-c3cccc(Cl)c3)n2)cn1 CHEMBL5184286 IC50 0.5 nM
O=C(NCC(F)(F)F)c1cn(-c2cccc(-c3ccc(C4CC4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801155 IC50 0.51 nM
COc1ccc(C2=NN(C3CCN(c4ccnc(N)n4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4522249 pKi 0.5129 nM
O=C(NC1CCC1)c1cn(-c2cccc(-c3ccc(C4CC4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801157 IC50 0.52 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3ccc([C@@H]4C[C@H]4C(=O)O)c(F)c3)c2)c2ncccc2c1=O CHEMBL1801160 IC50 0.53 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3cccc(C4CC4C(=O)O)c3)c2)c2ncccc2c1=O CHEMBL1801068 IC50 0.54 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3ccc(C4CC4c4nnn[nH]4)cc3)c2)c2ncccc2c1=O CHEMBL1801151 IC50 0.55 nM
COc1ccc(C2=NN(C3CN(c4ncnc5ccsc45)C3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4454600 pKi 0.5623 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3ccc(C4CC4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801067 IC50 0.57 nM
CC1(NC(=O)c2cn(-c3cccc(-c4ccc(C5CC5C(=O)O)cc4)c3)c3ncccc3c2=O)CC1 CHEMBL1801154 IC50 0.58 nM
CC(C)NC(=O)/C(=C/c1cccc(-c2cc(C(C)C)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL371089 IC50 0.6 nM
Cc1noc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccccn2)n1 CHEMBL197494 IC50 0.6 nM
CC(C)(O)CCc1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1 CHEMBL1221434 IC50 0.6 nM
COc1ccc(C2=NN(C3CCCCCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCCCCOc1ccc(-c2nnn[nH]2)cc1 CHEMBL2326941 pIC50 0.631 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801159 IC50 0.66 nM
COc1ccc(C2=NN(C3CCN(c4nc(N)nc5sccc45)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC CHEMBL4466777 pKi 0.6607 nM
COc1ccc(C2=NN(C3CCN(c4nc(N)c5sccc5n4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4472307 pKi 0.6761 nM
COc1ccc(C2=NN(C3CN(C(=O)CN4C(=O)CC5(CCCC5)CC4=O)C3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4461705 pKi 0.6761 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)NCC(C)C)CC3)nc12 CHEMBL4784121 IC50 0.68 nM
CC(C)NC(=O)/C(=C/c1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL371037 IC50 0.7 nM
CC(c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)N(C(=O)c1ccc(F)cc1)c1ccc(S(C)(=O)=O)cc1 CHEMBL208382 IC50 0.7 nM
CC(C)(c1cc(-c2cccc(C(=O)Nc3c(Cl)cncc3Cl)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL207996 IC50 0.7 nM
COc1ccc(C2=NN(Cc3ccc(Cn4ccnc4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL594109 IC50 0.7 nM
COc1ccc(-c2nc(C(=O)NCc3ccc(F)cc3F)c(CN)o2)c2ccc(C(F)(F)F)nc12 CHEMBL2012219 IC50 0.7 nM
COc1ccc(C2=NN(C3CCCC3)C(=O)C3CC=CCC23)cc1Cl CHEMBL4213295 IC50 0.78 nM
CC(C)NC(=O)N(Cc1cc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)ccc1F)c1ccc(S(C)(=O)=O)cc1 CHEMBL208100 IC50 0.8 nM
CS(=O)(=O)c1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1 CHEMBL1223686 IC50 0.8 nM
CC(C)(CC(=O)O)c1ccc(-c2cccc(-n3cc(C(=O)NC4CC4)c(=O)c4cccnc43)c2)cc1 CHEMBL1801071 IC50 0.85 nM
COc1ccc(C2=NN(C3CN(C(=O)CN4C(=O)CC5(CCCCC5)CC4=O)C3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4465097 pKi 0.8511 nM
COc1ccc(C2=NN(C3CCN(c4nc(N)nc5[nH]cnc45)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4452707 pKi 0.871 nM
CC(C)(Cc1ccc(-c2cccc(-n3cc(C(=O)NC4CC4)c(=O)c4cccnc43)c2)cc1)C(=O)O CHEMBL1801070 IC50 0.88 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCC(=O)CC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL595064 IC50 0.9 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCOCC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL593877 IC50 0.9 nM
N#CCCc1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1 CHEMBL1223685 IC50 0.9 nM
O=C(O)c1ccc(-c2cc3cccnc3c(-c3cccc([N+](=O)[O-])c3)n2)cc1 CHEMBL74078 IC50 1.0 nM
C[C@@H](NC(=O)c1cccnc1Oc1ccc(F)cc1)c1cccs1 CHEMBL204449 IC50 1.0 nM
COc1ccc(C2=NN(Cc3ccccc3CN3CCOCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC CHEMBL595272 IC50 1.0 nM
Cc1noc(/C(=C/c2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)n1 CHEMBL372575 IC50 1.0 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3ccc([C@@H]4C[C@H]4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801158 IC50 1.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)Nc2ccccc2)c1OC CHEMBL3315084 IC50 1.0 nM
COc1ccc(C2=NN(C3CN(c4nc(N)nc5sccc45)C3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4461658 pKi 1.175 nM
COc1ccc(F)c(CCCC2CCC(CCNCCCCCN3N=C(c4ccc(OC)c(OC)c4)[C@H]4CC=CC[C@H]4C3=O)O2)c1 CHEMBL451500 Ki 1.2 nM
COc1ccc(C2=NN(C3CCCCCC3)C(=O)C2(C)C)cc1OCCCCOc1ccc(-c2nn[nH]n2)cc1 CHEMBL2171452 IC50 1.2 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCC5(CC4)OCCO5)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL596447 IC50 1.3 nM
COc1ccc(C2=NN(Cc3ccccc3CN3CCOCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL592931 IC50 1.3 nM
CCNc1nc2oc3c(NCc4cccnc4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830790 IC50 1.3 nM
CC(c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)N(C(=O)C1CC1)c1ccc(S(C)(=O)=O)cc1 CHEMBL379768 IC50 1.4 nM
COc1ccc(C2=NN(Cc3cccc(CN4CCOCC4)c3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL596394 IC50 1.4 nM
COc1c(OCc2ccccc2)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5400816 IC50 1.4 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5431083 IC50 1.4 nM
O=C(O)c1ccc(-c2cc3cccnc3c(-c3ccc4nonc4c3)n2)cc1 CHEMBL77826 IC50 1.5 nM
CCNc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830644 IC50 1.5 nM
O=C(CN1C(=O)CC2(CCCCC2)CC1=O)N1CCC(N2N=C(c3ccc(OC(F)F)c(OC(F)F)c3)[C@H]3CC=CC[C@H]3C2=O)CC1 CHEMBL4533993 pKi 1.622 nM
CC(c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)N(C(=O)c1cccnc1)c1ccc(S(C)(=O)=O)cc1 CHEMBL206592 IC50 1.7 nM
CC1(C)CCc2c(N3CCOCC3)nc3sc4c(N(CCO)CCN5CCOCC5)ncnc4c3c2C1 CHEMBL1255597 IC50 1.8 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCCSC2CCOC2=O)c1 CHEMBL3327325 IC50 1.8 nM
Cc1noc(/C(=C\c2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)n1 CHEMBL198732 IC50 1.9 nM
CC(C)NC(=O)N(c1ccc(S(C)(=O)=O)cc1)C(C)c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1 CHEMBL207559 IC50 1.9 nM
COc1ccc(OC)c(-c2nnc3n2N=C(c2ccc(OC)c(O[C@@H]4CCOC4)c2)CS3)c1 CHEMBL564209 IC50 1.9 nM
O=C(O)c1ccc(-c2cc3cccnc3c(-c3cccc(Cl)c3)n2)cc1 CHEMBL161115 IC50 2.0 nM
O=[N+]([O-])c1cccc(-c2nc(-c3ccccc3)cc3cccnc23)c1 CHEMBL161465 IC50 2.0 nM
CC(c1cc(-c2cccc(/C=C(\c3ccc(S(C)(=O)=O)cc3)c3ncc(C(C)(C)O)s3)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL198722 IC50 2.0 nM
O=S(=O)(Nc1cccc(-c2cc(Cc3ccncc3)cc3cccnc23)c1)c1ccccc1 CHEMBL370220 IC50 2.0 nM
COc1ccc(F)cc1CCC1CCC(CCNCCCCCN2N=C(c3ccc(OC)c(OC)c3)[C@H]3CC=CC[C@H]3C2=O)O1 CHEMBL505431 Ki 2.0 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCN(C)CC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL595038 IC50 2.0 nM
COc1ccc(C2=NN(CCCCCBr)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL463431 IC50 2.0 nM
COc1cccc(-c2cc(COc3ccc(CCC#N)cc3)cc3cccnc23)c1 CHEMBL1224721 IC50 2.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC4CCCCC4)CC3)nc12 CHEMBL4740828 IC50 2.0 nM
COc1ccc([C@H](Cc2ccncc2)c2ccccc2)cc1OC1CCCC1 CHEMBL32442 IC50 2.1 nM
COc1ccc(OC)c(-c2nnc3ccc(-c4ccc(OC)c(O[C@@H]5CCOC5)c4)nn23)c1 CHEMBL549560 IC50 2.1 nM
COc1ccc([C@H](Cc2ccncc2)c2ccccc2)cc1OC1CCCC1 CHEMBL4474098 IC50 2.1 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3(C(=O)NCC(C)C)CC3)nc12 CHEMBL4779112 IC50 2.1 nM
CC(C)OCCOc1ncc(Oc2ccc3c(c2)B(O)OC3)cc1C#N CHEMBL5193314 IC50 2.1 nM
CC(C)NC(=O)/C(=C/c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL198527 IC50 2.3 nM
CC(C)(c1cc(-c2cccc(NC(=O)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL208236 IC50 2.3 nM
COc1ccc(C2=NN(CCCCCBr)C(=O)C3CC=CCC23)cc1OC CHEMBL480988 IC50 2.3 nM
CC1(C)CCc2c(N3CCOCC3)nc3oc4c(N(CCO)CCN5CCOCC5)ncnc4c3c2C1 CHEMBL1830638 IC50 2.3 nM
Cc1c[n+]([O-])ccc1CC(c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)c1ccc(OC(F)F)c(OC(F)F)c1 CHEMBL323312 IC50 2.4 nM
COc1ccc(C2=NN(C3CCN(c4nc(N)c5ccccc5n4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4575003 pKi 2.455 nM
COc1ccc(C2=NN(C3CCN(c4ncc5ccccc5n4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4472329 pKi 2.455 nM
COc1cccc(-c2cc(Cc3ccncc3)cc3cccnc23)c1 CHEMBL198432 IC50 2.5 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC4CCCCCC4)CC3)nc12 CHEMBL4750576 IC50 2.5 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC4CCCC4)CC3)nc12 CHEMBL4740242 IC50 2.5 nM
COc1ccc(C2=NN(C3CCN(c4ncc5sccc5n4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL4466905 pKi 2.57 nM
COc1ccc(C2=NOC(C(=O)NO)C2)cc1OC1CCCC1 CHEMBL307646 IC50 2.7 nM
CCNc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830641 IC50 2.7 nM
O=C(Nc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c2oc3ccncc3c12 CHEMBL4297527 IC50 2.7 nM
CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC CHEMBL514800 AC50 2.7 nM
O=C(Nc1ccc2ncsc2c1)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL4212323 IC50 2.73 nM
CC(C)(c1cc(-c2cccc(C(=O)Nc3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL208149 IC50 2.8 nM
[11CH3]Oc1ccc(Cc2ccncc2)nc1-c1cccc([N+](=O)[O-])c1 CHEMBL5207508 IC50 2.8 nM
O=[N+]([O-])c1cccc(-c2nc(-c3cccnc3)cc3cccnc23)c1 CHEMBL351613 IC50 3.0 nM
COC(=O)c1ccc(OCC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c-3n2)cc1 CHEMBL362175 Ki 3.0 nM
CC(C)(c1cc(-c2cccc(C(=O)Nc3ccncc3)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL383837 IC50 3.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)NCc2ccccc2)c1OC CHEMBL3315083 IC50 3.0 nM
N#Cc1cccc(-c2nc(N3CCOCC3)cc3cccnc23)c1 CHEMBL3605513 IC50 3.0 nM
C[C@@H](Oc1ccc(CNC(=O)c2cccnc2Oc2ccc3c(c2)OCO3)c(F)c1)C(=O)O CHEMBL3182164 IC50 3.0 nM
CC1(C)CCc2c(-c3ccoc3)nc3sc4c(NCCN5CCOCC5)ncnc4c3c2C1 CHEMBL1257189 IC50 3.1 nM
O=C(Nc1c(Cl)cncc1Cl)C(=O)c1cn(Cc2ccc(F)cc2)c2ncccc12 CHEMBL4568146 IC50 3.5 nM
COc1c(OCC2CC2)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5407967 IC50 3.5 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(OCC=O)c(OCC=O)c4)nc2-3)cc1OC1CCCC1 CHEMBL367846 Ki 3.7 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OCC(C)C)CC3)nc12 CHEMBL4747201 IC50 3.8 nM
[11CH3]Oc1ccc(Cc2cn[nH]c2)nc1-c1cccc([N+](=O)[O-])c1 CHEMBL5181462 IC50 3.9 nM
N#Cc1cccc(-c2nc(-c3ccc(C(=O)O)cc3)cc3cccnc23)c1 CHEMBL161740 IC50 4.0 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)O)nc2-3)cc1OC1CCCC1 CHEMBL1203921 Ki 4.1 nM
CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1258806 IC50 4.2 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OCCCC(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4866569 IC50 4.2 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(C(C)(C)C)cc4)nc2-3)cc1OC1CCCC1 CHEMBL360481 Ki 4.3 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCOCC4)cc3)C(=O)[C@@H]3CC[C@H]23)cc1OC CHEMBL605096 IC50 4.3 nM
CC(C)c1cc(-c2cccc(CC(c3ccncc3)C(C)(C)O)c2)c2ncccc2c1 CHEMBL198564 IC50 4.4 nM
CCOc1cccc(-c2cc(COc3ccc(CCC#N)cc3)cc3cccnc23)c1 CHEMBL1223621 IC50 4.5 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCCSC(CCO)C(=O)O)c1 CHEMBL3327326 IC50 4.5 nM
CC[C@@H](C)OC(=O)C1(c2nc3c(OC)ccc(-c4ccc5c(c4)COC5=O)n3n2)CC1 CHEMBL4739987 IC50 4.5 nM
O=C(Nc1ccc2nc(S)sc2c1)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL4206638 IC50 4.54 nM
CC1(C)CCc2c(N3CCOCC3)nc3sc4c(NCCN5CCOCC5)ncnc4c3c2C1 CHEMBL1258124 IC50 4.6 nM
O=C(NC1CC1)c1cn(-c2cccc(-c3ccccc3C3CC3C(=O)O)c2)c2ncccc2c1=O CHEMBL1801069 IC50 4.6 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(Cl)cc4)nc2-3)cc1OC1CCCC1 CHEMBL180015 Ki 4.8 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(C(N)=O)cc4)nc2-3)cc1OC1CCCC1 CHEMBL178801 Ki 4.9 nM
COc1cccc(-c2cc(COc3ccccc3Cl)cc3cccnc23)c1 CHEMBL1224718 IC50 5.0 nM
CCCNC(=O)COc1c(C(=O)Cc2c(Cl)cncc2Cl)ccc(OC)c1OC CHEMBL3315088 IC50 5.0 nM
COc1ccc(C(=O)Cc2c(Cl)c[n+]([O-])cc2Cl)c(OCC(=O)NCc2ccccc2)c1OC CHEMBL3315089 IC50 5.0 nM
O=C(Nc1nc2ccccc2s1)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL4213078 IC50 5.07 nM
COc1ccccc1OCC(C)(C)c1nc2c(N)ncn(Cc3ccc(OC)c(OC4CCCC4)c3)c-2n1 CHEMBL360527 Ki 5.1 nM
COc1cccc(OCC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c-3n2)c1 CHEMBL433761 Ki 5.1 nM
O=C(NC1CC1)c1cn(-c2cccc(C#Cc3ccc[n+]([O-])c3)c2)c2ncccc2c1=O CHEMBL485629 IC50 5.1 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3(COC(=O)C(C)C)CC3)nc12 CHEMBL4741065 IC50 5.1 nM
[11CH3]Oc1ccc(Cc2ccncc2)nc1-c1cccc(Cl)c1 CHEMBL5172644 IC50 5.12 nM
COc1ccc(C2=NN(CCOCCn3ccnc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL595959 IC50 5.2 nM
COc1c(OC(C)C)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5408080 IC50 5.2 nM
CC(C)=C[C@H]1Oc2cc(O)ccc2-c2oc3c4c(cc(O)c3c(=O)c21)OC(C)(C)C=C4 CHEMBL4168752 IC50 5.4 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCSC2CCOC2=O)c1 CHEMBL3327321 IC50 5.5 nM
COc1ccc(OCC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c-3n2)cc1 CHEMBL368696 Ki 5.6 nM
CC[C@H](C)OC(=O)C1(c2nc3c(OC)ccc(-c4ccc5c(c4)COC5=O)n3n2)CC1 CHEMBL4764289 IC50 5.7 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)OCc4ccsc4)nc2-3)cc1OC1CCCC1 CHEMBL455139 Activity 6.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccc(I)c4)nn23)cc1OCC1CC1 CHEMBL602666 IC50 6.0 nM
CSc1cccc(-c2nc([C@H]3CC[C@H](C(=O)O)CC3)cc3cccnc23)c1 CHEMBL2172376 IC50 6.0 nM
CNc1cc(Nc2cc(C)cc(C)c2)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4293907 IC50 6.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC(C)(C)C)CC3)nc12 CHEMBL4761069 IC50 6.0 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccccc4-c4cccs4)nc2-3)cc1OC1CCCC1 CHEMBL433757 Ki 6.3 nM
COc1ccc(C2=NNC(=O)C3CC=CCC23)cc1OC CHEMBL313041 Ki 6.3 nM
COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 CHEMBL63 Log IC50 6.4 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(OC(F)(F)F)cc4)nc2-3)cc1OC1CCCC1 CHEMBL360932 Ki 6.5 nM
CCOC(=O)/C=C/COc1c2c(cc3oc4cc(OCc5cccc(F)c5)c(OC)c(CC=C(C)C)c4c(=O)c13)OC(C)(C)C=C2 CHEMBL4848450 IC50 6.5 nM
COc1c(OCc2ccccn2)cc2oc3cc4c(c(OCc5ccccn5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5421333 IC50 6.5 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(C)cc4)nc2-3)cc1OC1CCCC1 CHEMBL360770 Ki 6.6 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(Cl)c(Cl)c4)nc2-3)cc1OC1CCCC1 CHEMBL433774 Ki 6.6 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4cccc(-c5ccsc5)c4)nc2-3)cc1OC1CCCC1 CHEMBL179321 Ki 6.6 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCCNC2CCOC2=O)c1 CHEMBL3327323 IC50 6.6 nM
CC(=O)N(c1ccc(S(C)(=O)=O)cc1)C(C)c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1 CHEMBL204522 IC50 6.7 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccccc4F)nc2-3)cc1OC1CCCC1 CHEMBL178460 Ki 6.8 nM
C=CCc1cc2cccnc2c(-c2cccc([N+](=O)[O-])c2)n1 CHEMBL351500 IC50 7.0 nM
CCc1nc(Nc2ccc(CC#N)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3313945 IC50 7.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2)n2nc(C3(C(=O)NCC(C)C)CC3)nc12 CHEMBL4744621 IC50 7.0 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCN[C@@H]2CCOC2=O)c1 CHEMBL3327316 IC50 7.3 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4cccc(F)c4)nc2-3)cc1OC1CCCC1 CHEMBL361201 Ki 7.4 nM
COC(=O)c1cccc(-c2ccc(OC)c3nc(C4(C(=O)NCC(C)C)CC4)nn23)c1 CHEMBL4795054 IC50 7.4 nM
O=C(O)Cc1ccc(Cc2cc(-c3cccc(Cl)c3)nc(C(F)(F)F)c2)cc1 CHEMBL4541964 IC50 7.4 nM
COc1ccc(OCC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c-3n2)cc1OC CHEMBL178099 Ki 7.8 nM
COc1c(OCc2cccc(F)c2)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5420700 IC50 7.8 nM
COc1cccc(COc2cc(C(=O)O)cc(N3CC(c4ccc(OC)c(OC5CCCC5)c4)CC3=O)c2)c1 CHEMBL322092 Log IC50 7.9 nM
COc1cc(OC)cc(OCC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c-3n2)c1 CHEMBL178712 Ki 7.9 nM
CC1(C)CCc2c(-c3ccco3)nc3sc4c(NCCN5CCOCC5)ncnc4c3c2C1 CHEMBL1257188 IC50 7.9 nM
O=[N+]([O-])c1cccc(-c2nc(-c3ccco3)cc3cccnc23)c1 CHEMBL162188 IC50 8.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCCc2ccc(O)cc2)c1OC CHEMBL3315079 IC50 8.0 nM
N#Cc1cccc(-c2nc(N3CCC(C(N)=O)CC3)cc3cccnc23)c1 CHEMBL3605510 IC50 8.0 nM
NC(=O)Cc1ccc(Nc2cc(C(F)(F)F)nc(-c3cccc(Cl)c3)n2)cc1 CHEMBL4209111 IC50 8.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC4CCC4)CC3)nc12 CHEMBL4745874 IC50 8.0 nM
COc1ccc(-c2cccc(C(C)=O)c2)n2nc(C3CC3)nc12 CHEMBL4796321 IC50 8.0 nM
COc1cccc(COc2cccc(N3CC(c4ccc(OC)c(OC5CCCC5)c4)CC3=O)c2)c1 CHEMBL320307 Log IC50 8.1 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCCCC4)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL603626 IC50 8.2 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OCc5cccnc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5440771 IC50 8.2 nM
COc1cccc(COc2cc(C(=O)NN(C)C)cc(N3CC(c4ccc(OC)c(OC5CCCC5)c4)CC3=O)c2)c1 CHEMBL326655 Log IC50 8.8 nM
CCc1nn(C2CCCC2)c2c1CCn1c-2nnc1C(C)(C)C CHEMBL218103 IC50 9.0 nM
O=C(O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598086 IC50 9.0 nM
COc1ccc(-c2ccc(C(=O)O)c(CO)c2)n2nc(C3(C(=O)NCC(C)C)CC3)nc12 CHEMBL4792140 IC50 9.0 nM
CCCCOC(=O)C1(c2nc3c(OC)ccc(-c4ccc5c(c4)COC5=O)n3n2)CC1 CHEMBL4753953 IC50 9.0 nM
COc1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1 CHEMBL1224653 IC50 9.3 nM
COc1c(OCc2cccc(F)c2)cc2oc3cc4c(c(OCc5ccccn5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5435764 IC50 9.3 nM
CC1(C)CCc2c(N3CCOCC3)nc3oc4c(NCCN5CCOCC5)ncnc4c3c2C1 CHEMBL1830636 IC50 9.4 nM
COc1ccc(C2=NN(Cc3ccc(CN(C)C)cc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL595039 IC50 9.7 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(C(F)(F)F)cc4)nc2-3)cc1OC1CCCC1 CHEMBL368739 Ki 9.9 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCSC(CCO)C(=O)O)c1 CHEMBL3327322 IC50 9.9 nM
COc1ccc(C2=NOC(C)(C(=O)NO)C2)cc1OC1CCCC1 CHEMBL91551 IC50 10.0 nM
CC(C)NC(=O)N(Cc1cc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)ccc1Cl)c1ccc(S(C)(=O)=O)cc1 CHEMBL207424 IC50 10.0 nM
CC(C)(c1cc(-c2cccc(C(=O)Nc3ccccc3)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL207775 IC50 10.0 nM
COc1ccc(C2(c3ccc(OC)cc3)c3cc(O)ccc3-c3ccc(C=O)c(C#Cc4ccc(O)cc4)c32)cc1 CHEMBL4460827 IC50 10.0 nM
CCOc1cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c(CC=C(C)C)c1OC)C=CC(C)(C)O4 CHEMBL5434362 IC50 10.2 nM
N#CCCc1ccc(OCc2cc(-c3cccc(F)c3)c3ncccc3c2)cc1 CHEMBL1223620 IC50 10.5 nM
COc1c(OCc2ccncc2)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5434713 IC50 10.6 nM
O=[N+]([O-])c1cccc(-c2nc(OS(=O)(=O)C(F)(F)F)cc3cccnc23)c1 CHEMBL351900 IC50 11.0 nM
COc1ccc([C@]2(C#N)CC[C@@H](C(=O)O)CC2)cc1OC1CCCC1 CHEMBL511115 IC50 11.0 nM
CC1(C)CCc2c(N3CCCC3)nc3sc4c(NCCN5CCOCC5)ncnc4c3c2C1 CHEMBL1258470 IC50 11.0 nM
CNC(=O)c1ccc(CCOc2c(C(=O)Cc3c(Cl)cncc3Cl)ccc(OC)c2OC)cc1 CHEMBL3315080 IC50 11.0 nM
COc1ccc([C@@]2(c3cccc(OC)c3)c3cc(O)ccc3-c3ccc(C=O)c(C#Cc4ccc(O)cc4)c32)cc1 CHEMBL4751199 IC50 11.0 nM
COc1cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c(CC=C(C)C)c1OC)C=CC(C)(C)O4 CHEMBL5438159 IC50 11.7 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC4CCOCC4)CC3)nc12 CHEMBL4757090 IC50 12.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)O[C@H]4CCOC4)CC3)nc12 CHEMBL4782606 IC50 12.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC(C)C)CC3)nc12 CHEMBL4753380 IC50 12.0 nM
CCCOC(=O)C1(c2nc3c(OC)ccc(-c4ccc5c(c4)COC5=O)n3n2)CC1 CHEMBL4759431 IC50 12.0 nM
CC(C)CC(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1 CHEMBL458298 IC50 12.0 nM
COc1cccc(-c2cc(COc3cccc(Cl)c3)cc3cccnc23)c1 CHEMBL1224719 IC50 12.1 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OCC5CCNCC5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5410553 IC50 12.4 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(F)c(F)c4)nc2-3)cc1OC1CCCC1 CHEMBL369134 Ki 13.0 nM
CCc1nn(C2CCCC2)c2c1CCn1c(-c3cccs3)nnc1-2 CHEMBL217899 IC50 13.0 nM
CCc1nn(C2CCCC2)c2c1CCn1c(-c3ccccc3Cl)nnc1-2 CHEMBL218653 IC50 13.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccc(Br)c4)nn23)cc1OCC1CC1 CHEMBL603071 IC50 13.0 nM
CC1(C)CCc2c(N3CCOCC3)nc3sc4c(NCc5ccncc5)ncnc4c3c2C1 CHEMBL1257654 IC50 13.0 nM
CC1(C)CCc2c(N3CCOCC3)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1 CHEMBL1830635 IC50 13.0 nM
CCc1nc(Nc2ccc(C#N)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315271 IC50 13.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)cc1OC CHEMBL3315072 IC50 13.0 nM
COCCNC(=O)COc1c(C(=O)Cc2c(Cl)cncc2Cl)ccc(OC)c1OC CHEMBL3315087 IC50 13.0 nM
N#Cc1cccc(-c2nc(N3CCC(CO)CC3)cc3cccnc23)c1 CHEMBL3605511 IC50 13.0 nM
CNc1cc(Nc2c(F)c(F)cc(F)c2F)nn2c(C(=O)NC[C@](C)(O)CO)cnc12 CHEMBL4291200 IC50 13.0 nM
CC1(C)CCc2c(NCCO)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1 CHEMBL1830640 IC50 13.5 nM
CCN(C)c1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830642 IC50 14.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC[C@@H](C)CO)CC3)nc12 CHEMBL4791500 IC50 14.0 nM
COc1ccc(-c2ccc3c(c2)CCC3=O)n2nc(C3CC3)nc12 CHEMBL4781717 IC50 14.0 nM
COc1ccc(C2=NN(CC(=O)NCCCn3ccnc3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL605935 IC50 14.3 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCCc2ccccc2)c1OC CHEMBL3315077 IC50 15.0 nM
CNc1cc(Nc2cc(C)cc(C)c2)nn2c(C(=O)NCC(C)(C)CO)cnc12 CHEMBL4289426 IC50 15.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OCC(C)(C)O)CC3)nc12 CHEMBL4760404 IC50 15.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3CC3)nc12 CHEMBL4748609 IC50 15.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC[C@H](C)CO)CC3)nc12 CHEMBL4792758 IC50 15.0 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4877549 IC50 15.0 nM
COc1ccc(C(=O)NCC(=O)NO)cc1OC1CCCC1 CHEMBL91571 IC50 15.6 nM
COc1c(OCCCCCCCC(=O)O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4453774 IC50 16.0 nM
COc1cccc(COc2cc3oc4cc5c(c(OC/C=C/C(=O)O)c4c(=O)c3c(CC=C(C)C)c2OC)C=CC(C)(C)O5)c1 CHEMBL4852720 IC50 16.0 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCOCC4)cc3)C(=O)[C@@H]3C[C@H]23)cc1OC CHEMBL603194 IC50 16.4 nM
N#CCCc1ccc(OCc2cc(-c3cccc(OC(F)(F)F)c3)c3ncccc3c2)cc1 CHEMBL1223619 IC50 17.0 nM
O=C(NC1(O)CC1)c1cn(-c2cccc(-c3ccc(C4CC4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801153 IC50 17.0 nM
CCN(C)c1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830645 IC50 17.0 nM
COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)cc1OC CHEMBL48017 IC50 17.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCCc2ccc(C(=O)O)cc2)c1OC CHEMBL3315081 IC50 17.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)NCCO)c1OC CHEMBL3315086 IC50 17.0 nM
COc1c(OCCCCCCC(=O)O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4471352 IC50 17.0 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3(C(=O)OCC(C)C)CC3)nc12 CHEMBL4742661 IC50 17.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)O[C@@H]4CCOC4)CC3)nc12 CHEMBL4745639 IC50 17.0 nM
COc1c(O)cc2oc3cc4c(c(OCC(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4874476 IC50 17.0 nM
COc1ccc(C2=Nn3c(nnc3-c3ccccc3OC)SC2)cc1OC CHEMBL251785 IC50 18.0 nM
CC(=O)Oc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL604107 IC50 18.0 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCNC2CCOC2=O)c1 CHEMBL3327315 IC50 18.0 nM
CNc1cc(Nc2cc(C)cc(C)c2)nn2c(C(=O)NCC(C)(CO)CO)cnc12 CHEMBL4278757 IC50 18.0 nM
COc1c(OCc2ccc(S(C)(=O)=O)cc2)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4878562 IC50 18.0 nM
Cc1cccc(-c2cc(COc3ccc(CCC#N)cc3)cc3cccnc23)c1 CHEMBL1223684 IC50 18.3 nM
CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(N(CCN5CCOCC5)Cc5cccnc5)ncnc4c23)CO1 CHEMBL1255772 IC50 19.0 nM
N#Cc1cccc(-c2nc(N3CCC(C(=O)O)CC3)cc3cccnc23)c1 CHEMBL2172370 IC50 19.0 nM
COc1ccc(-c2cccc3c2CCC3=O)n2nc(C3CC3)nc12 CHEMBL4761621 IC50 19.0 nM
COc1ccc(Cn2cnc(N)c3nc(C(C)(C)COc4ccc(C#N)cc4)nc2-3)cc1OC1CCCC1 CHEMBL360285 Ki 19.4 nM
COc1ccc(-c2ccnc3cc(-c4cccc(Cl)c4)nn23)cc1OC1CCCC1 CHEMBL600990 IC50 20.0 nM
O=C(O)c1ccc(Nc2nc(-c3cccc(Cl)c3)nc(C3CC3)n2)cc1 CHEMBL3315265 IC50 20.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(N)=O)c1OC CHEMBL3315090 IC50 20.0 nM
COC1CC(C)(C)Oc2cc(O)c3c(=O)c(CC=C(C)C)c(-c4ccc(O)cc4O)oc3c21 CHEMBL4171877 IC50 20.0 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3CC3)nc12 CHEMBL4748795 IC50 20.0 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OC/C=C\C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4877677 IC50 20.0 nM
COc1ccc(C(=O)NC(C)C(=O)NO)cc1OC1CCCC1 CHEMBL90375 IC50 20.2 nM
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OCc5ccccn5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5405731 IC50 20.2 nM
Oc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598670 IC50 21.0 nM
CCOC(=O)c1c(C)nn(-c2cccc([N+](=O)[O-])c2)c1C CHEMBL1230564 IC50 21.0 nM
CC(C)CC(=O)c1ccc(OC(F)F)c(OC2CCCC2)c1 CHEMBL511686 pIC50 21.88 nM
CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1 CHEMBL97817 IC50 22.0 nM
CCOC(=O)c1c(NC(=O)Cc2cccs2)sc2c1CCN(C(=O)OCC)C2 CHEMBL1922946 IC50 22.0 nM
N#Cc1cccc(-c2nc(N3CCC(O)CC3)cc3cccnc23)c1 CHEMBL3605512 IC50 22.0 nM
O=C(Nc1ccccc1Cl)c1ccc(OC(F)F)c(OC2CCCC2)c1 CHEMBL3883753 IC50 22.0 nM
N#CCCc1ccc(OCc2cc(-c3ccccc3)c3ncccc3c2)cc1 CHEMBL1223618 IC50 22.2 nM
COc1ccc(C2=NN(CCCCCNCC[C@H](Oc3cccc4ccccc34)c3cccs3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL596185 IC50 23.0 nM
CN(C)C(=O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598909 IC50 23.0 nM
O=C(O)[C@H]1CC[C@H](c2cc3cccnc3c(-c3cccc(OC(F)(F)F)c3)n2)CC1 CHEMBL2172373 IC50 24.0 nM
CNc1cc(Nc2cccc3c2OCCO3)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4285841 IC50 24.0 nM
COc1ccc(-c2cccc3c2COC3=O)n2nc(C3(C(=O)NCC(C)C)CC3)nc12 CHEMBL4739866 IC50 24.0 nM
COc1c(O)cc2oc3cc4c(c(OCCCCC(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4852619 IC50 24.0 nM
COc1c(OCc2ccccc2)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4871290 IC50 24.0 nM
CCOC(=O)/C=C/COc1c2c(cc3oc4cc(OCc5ccc(F)cc5)c(OC)c(CC=C(C)C)c4c(=O)c13)OC(C)(C)C=C2 CHEMBL4870288 IC50 24.0 nM
COc1ccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)cc1OC CHEMBL603892 IC50 25.0 nM
CN(C)c1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2c1COC(C)(C)C2 CHEMBL1258807 IC50 25.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)cnc21 CHEMBL4577198 IC50 25.0 nM
COc1c(O)cc2oc3cc4c(c(OCCCCCC(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4871033 IC50 25.0 nM
COc1c(O)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5437810 IC50 25.0 nM
COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC CHEMBL4128481 IC50 26.3 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccnc4)nn23)cc1OCC1CC1 CHEMBL604519 IC50 27.0 nM
CCNC(=O)N1CCc2c(sc(NC(=O)Cc3ccccc3)c2C(=O)OCC)C1 CHEMBL1923066 IC50 27.0 nM
COc1ccc(Cc2ccc(NC(N)=O)cc2)cc1-c1cccc(Cl)c1 CHEMBL3184687 IC50 27.0 nM
CCNC(=O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598907 IC50 28.0 nM
COc1ccc(C(=O)Nc2c(Cl)cccc2Cl)cc1OC1CCCC1 CHEMBL45834 pIC50 28.18 nM
COc1cc(OC)cc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL604930 IC50 29.0 nM
COc1ccc(-c2ccnc3cc(-c4cccc(Br)c4)nn23)cc1OC1CCCC1 CHEMBL605362 IC50 30.0 nM
COc1ccc(-c2ccnc3cc(-c4cc(Cl)ccc4Cl)nn23)cc1OC1CCCC1 CHEMBL606214 IC50 30.0 nM
COc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL589514 IC50 30.0 nM
O=C(O)C1CCN(c2cc3cccnc3c(-c3cccc(OC(F)(F)F)c3)n2)CC1 CHEMBL2172367 IC50 30.0 nM
O=C(O)C1CCN(c2cc3cccnc3c(-c3cccc(Cl)c3)n2)CC1 CHEMBL2172369 IC50 30.0 nM
O=C(O)[C@H]1CC[C@H](c2cc3cccnc3c(-c3cccc(Cl)c3)n2)CC1 CHEMBL3605509 IC50 30.0 nM
CC1(C)C=Cc2c(ccc(-c3cc(=O)c4c(O)cc5c(c4o3)C=CC(C)(C)O5)c2O)O1 CHEMBL4170837 IC50 30.0 nM
COc1cc2c(cc1OC)[C@@H]1CN(C)CC[C@@H]1N=C2c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1 CHEMBL2104505 IC50 30.0 nM
COc1cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c(CC=C(C)C)c1OC)C=CC(C)(C)O4 CHEMBL4860780 IC50 30.0 nM
COc1ccc(C2=NN(C3CCN(c4nc(N)nc5sccc45)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1Cl CHEMBL4462322 pKi 30.2 nM
COc1ccc(/C=N/N(C)C(=O)c2ccc(O)cc2)cc1OC CHEMBL2172710 IC50 31.0 nM
COc1c(OC(C)C)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4876689 IC50 31.0 nM
C=CCOc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL605146 IC50 32.0 nM
CS(=O)(=O)CNc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL603230 IC50 32.0 nM
COc1ccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)cc1O CHEMBL598745 IC50 32.0 nM
CC1(C)CCc2c(N3CCOCC3)nc3sc4c(NCc5cccnc5)ncnc4c3c2C1 CHEMBL1257536 IC50 32.0 nM
CC(C)(C)NC(=O)c1cn(-c2cccc(-c3ccc(C4CC4C(=O)O)cc3)c2)c2ncccc2c1=O CHEMBL1801152 IC50 32.0 nM
O=C(O)[C@H]1CC[C@H](c2cc3cccnc3c(-c3cccc(F)c3)n2)CC1 CHEMBL2172374 IC50 32.0 nM
COC(=O)CNCCCOc1cc(C(=O)Nc2c(Cl)cncc2Cl)ccc1OC(F)F CHEMBL3327328 IC50 32.0 nM
CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(C(=O)NCC(C)(C)CO)cnc12 CHEMBL4287761 IC50 32.0 nM
O=C(O)C1CCC(c2cc3cccnc3c(-c3cccc(F)c3)n2)CC1 CHEMBL4303204 IC50 32.0 nM
Cc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1258921 IC50 34.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccc(Cl)c4)nn23)cc1OCC1CC1 CHEMBL605355 IC50 36.0 nM
CNc1cc(Nc2cc(C)cc(C)c2)nc2c(C(=O)NC3CC3)cnn12 CHEMBL5420172 IC50 36.0 nM
COC(=O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598719 IC50 37.0 nM
COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OC4COC4)CC3)nc12 CHEMBL4753567 IC50 37.0 nM
CC(C)c1cc(-c2cccc(C(Cc3ccncc3)c3ccc(Cl)cc3)c2)c2ncccc2c1 CHEMBL382545 IC50 38.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccc(C(F)F)c4)nn23)cc1OCC1CC1 CHEMBL599109 IC50 39.0 nM
CC(C)Cc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1258922 IC50 39.0 nM
CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(N(CCO)CCN5CCOCC5)ncnc4c23)CO1 CHEMBL1257778 IC50 39.0 nM
O=C(Nc1ccccc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL3884788 IC50 39.0 nM
COc1cccc(-c2cc3nccc(-c4ccc(OC)c(OC5CCCC5)c4)n3n2)c1 CHEMBL603070 IC50 40.0 nM
CNc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598049 IC50 40.0 nM
N#CNc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL597071 IC50 40.0 nM
CC(C)OC(=O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598500 IC50 40.0 nM
CC(C)=CCc1c(O)cc(O)c2c(=O)c3c(oc12)-c1ccc(O)cc1OC3C=C(C)C CHEMBL4168522 IC50 40.0 nM
N#Cc1cccc(-c2nc([C@H]3CC[C@H](C(=O)O)CC3)cc3cccnc23)c1 CHEMBL2172375 IC50 41.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCNc3c4c(nc5ccccc35)CCCC4)cnc21 CHEMBL4538132 IC50 41.0 nM
[O-][n+]1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL599326 IC50 42.0 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3(CCCO)CC3)nc12 CHEMBL4754336 IC50 42.0 nM
CCOc1cc2c(cc1OC)CCN(C=O)[C@H]2Cc1c[nH]c2ccccc12 CHEMBL4865688 IC50 42.0 nM
C[C@@H]1COCCN1c1cc(N2CCOC[C@@H]2C)cc2sc(-c3cc[nH]n3)nc12 CHEMBL5408310 IC50 42.0 nM
[O-][n+]1cccc(C[C@H](c2ccc(OC(F)F)c(OC3CC3)c2)c2cnc(C(O)(C(F)(F)F)C(F)(F)F)s2)c1 CHEMBL383762 IC50 43.0 nM
COCCNc1cc(O)c2c(=O)c3c(-c4nccs4)[nH]c(Cc4ccc5c(c4)OCO5)c3oc2c1 CHEMBL4218772 IC50 43.0 nM
CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(C(=O)NC[C@](C)(O)CO)cnc12 CHEMBL4279883 IC50 43.0 nM
CC(C)(C)NC(=O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL608268 IC50 44.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccc(-n5cnnn5)c4)nn23)cc1OCC1CC1 CHEMBL599526 IC50 44.0 nM
COc1c(OCCCC(=O)O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4529685 IC50 44.0 nM
CC(C)c1cc(-c2cccc(C(Cc3cc[n+]([O-])cc3)c3ccc(Cl)cc3)c2)c2ncccc2c1 CHEMBL198464 IC50 45.0 nM
COc1ccc(C2=NN(CCCCCNCC[C@@H](Oc3cccc4ccccc34)c3cccs3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL596175 IC50 45.0 nM
COc1cccc(-c2nc(N3CCC(C(=O)O)CC3)cc3cccnc23)c1 CHEMBL2172366 IC50 45.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCCCc2ccccc2)c1OC CHEMBL3315078 IC50 45.0 nM
COc1ccc(C2=NN(Cc3ccc(CN4CCOCC4)cc3)C(=O)CC2)cc1OC CHEMBL592942 IC50 45.9 nM
CC(C)Oc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL605340 IC50 46.0 nM
Nc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598671 IC50 46.0 nM
CN(CCN)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL597078 IC50 47.0 nM
O=S(=O)(Oc1cc2cccnc2c(-c2cccc(Cl)c2)n1)C(F)(F)F CHEMBL161714 IC50 48.0 nM
CCOc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598116 IC50 48.0 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCN[C@H]2CCOC2=O)c1 CHEMBL3327317 IC50 48.0 nM
CCOc1cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c(CC=C(C)C)c1OC)C=CC(C)(C)O4 CHEMBL4860301 IC50 48.0 nM
COc1cccc(-c2cc(COc3ccc(C(F)(F)F)cc3)cc3cccnc23)c1 CHEMBL1224720 IC50 48.7 nM
COc1ccc(OC)c(-c2nnc3n2N=C(c2ccc(OC)c(OC)c2)CS3)c1 CHEMBL252387 IC50 49.2 nM
COC(=O)c1ccc(-c2ccc(OC)c3nc(C4CC4)nn23)cc1 CHEMBL4791384 IC50 50.0 nM
O=C(O)C1CCN(c2cc3cccnc3c(-c3cccc(F)c3)n2)CC1 CHEMBL2172368 IC50 51.0 nM
CSc1cccc(-c2nc(N3CCC(C(=O)O)CC3)cc3cccnc23)c1 CHEMBL2172371 IC50 51.0 nM
CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NCc5cccnc5)ncnc4c23)CO1 CHEMBL1257422 IC50 52.0 nM
CC(C)(C)OC(=O)N1CCN(c2cccc(-c3cc4nccc(-c5ccc(OC(F)F)c(OCC6CC6)c5)n4n3)c2)CC1 CHEMBL600468 IC50 54.0 nM
COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCC(C(=O)O)CC3)c12 CHEMBL3938524 IC50 55.0 nM
N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1 CHEMBL484785 IC50 55.0 nM
COc1c(OCCCCCCCCC(=O)O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4435746 IC50 58.0 nM
CCS(=O)(=O)N1CCC(n2c(=O)n(-c3cccc(Cl)c3)c(=O)c3cnc4c(OC)cccc4c32)CC1 CHEMBL3644505 IC50 59.0 nM
CCOc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1 CHEMBL97214 IC50 60.0 nM
COc1ccc(-c2cc3nccc(-c4ccc(OC)c(OC5CCCC5)c4)n3n2)cc1 CHEMBL600989 IC50 60.0 nM
CCOC(=O)C1(c2nc3c(OC)ccc(-c4ccc5c(c4)COC5=O)n3n2)CC1 CHEMBL4746850 IC50 60.0 nM
CCCCC(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1 CHEMBL508134 IC50 61.0 nM
CC1(C)CCc2c(N3CCOCC3)nc3sc4c(NCCCN5CCCC5=O)ncnc4c3c2C1 CHEMBL1257421 IC50 61.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)N(C)c2ccccc2)c1OC CHEMBL3315085 IC50 61.0 nM
CNc1cc(Nc2cc(C)cc(C)c2)nn2c(C(N)=O)cnc12 CHEMBL4279157 IC50 62.0 nM
CCc1nc(Nc2ccc(Cc3nnn[nH]3)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315273 IC50 63.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCc2ccccc2)c1OC CHEMBL3315076 IC50 63.0 nM
O=C1[C@@H]2CC=CC[C@@H]2C(c2ccc(O)c(O)c2)=NN1C1CCN(c2ncnc3ccsc23)CC1 CHEMBL4451207 pKi 63.1 nM
COc1cccc(-c2nc([C@H]3CC[C@H](C(=O)O)CC3)cc3cccnc23)c1 CHEMBL2172372 IC50 64.0 nM
O=C(c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1)N1CCCCC1 CHEMBL604731 IC50 65.0 nM
CCN(CC)C(=O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL599525 IC50 67.0 nM
O=C(Nc1cccnc1)c1ccc(OC(F)F)c(OC2CCCC2)c1 CHEMBL3885161 IC50 68.0 nM
Cc1ccccc1-c1cc2cccnc2c(-c2cccc([N+](=O)[O-])c2)n1 CHEMBL345360 IC50 70.0 nM
CCc1nn(C2CCCC2)c2c1CCn1c(-c3cccnc3)nnc1-2 CHEMBL218990 IC50 70.0 nM
COc1ccc(-c2ccnc3cc(-c4ccccc4)nn23)cc1OC1CCCC1 CHEMBL597718 IC50 70.0 nM
COc1ccc(-c2ccnc3cc(-c4ccccc4OC)nn23)cc1OC1CCCC1 CHEMBL606386 IC50 70.0 nM
CCOc1ccc(-c2nc(-c3cccc(C(=O)O)n3)cs2)cc1OCC CHEMBL332750 IC50 70.0 nM
COc1ccc(C(=O)Nc2c(F)cccc2F)cc1OC1CCCC1 CHEMBL47113 pIC50 70.79 nM
O=C(Nc1cccnc1)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL3884224 IC50 71.0 nM
N#Cc1cccc(-c2nc(OS(=O)(=O)C(F)(F)F)cc3cccnc23)c1 CHEMBL158286 IC50 72.0 nM
COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCC(NS(C)(=O)=O)CC3)c12 CHEMBL3945875 IC50 73.0 nM
CC(C)(c1cc(-c2cccc(C(N)=O)c2)c2ncccc2c1)S(C)(=O)=O CHEMBL210840 IC50 74.0 nM
COc1ccc(C(=O)N(C)/N=C/c2ccc(OC)c(OC)c2)cc1 CHEMBL2172734 IC50 74.0 nM
CCOc1cc(C(CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC CHEMBL475165 IC50 74.0 nM
CCOc1cc2c(cc1OC)CCN(C=O)C2Cc1c[nH]c2ccccc12 CHEMBL4862887 IC50 75.0 nM
COc1c(OCCCCCC(=O)O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4473291 IC50 76.0 nM
COc1ccc(C2=NN(C(C)C)C(=O)[C@@H]3CC=CC[C@H]23)cc1C#CC(=O)NCc1ccccc1 CHEMBL4436770 pKd 79.43 nM
COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)CS(C)(=O)=O)CC3)c12 CHEMBL3644506 IC50 80.0 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3(CCC(=O)O)CC3)nc12 CHEMBL4753710 IC50 80.0 nM
CCOc1c(OC)ccc(C(=O)Cc2c(Cl)cncc2Cl)c1OC CHEMBL3313943 IC50 81.0 nM
C=CCc1c(CC)nc(-c2ccccc2)nc1Nc1ccc(C(=O)O)cc1 CHEMBL1784118 IC50 82.0 nM
N#CCCNc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598085 IC50 83.0 nM
COc1ccc(C2=NNC(=O)[C@@H]3CC=CC[C@H]23)cc1OC CHEMBL440878 IC50 85.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)cnc21 CHEMBL4454965 IC50 87.0 nM
CNc1cc(Nc2ccccc2OC)nn2c(C(=O)NCC(C)(C)CO)cnc12 CHEMBL4295039 IC50 88.0 nM
COc1cc2c(-c3cc(OCC4CC4)cc(OCC4CC4)c3)nc(OCCO)nc2cc1OCCO CHEMBL98662 IC50 90.0 nM
COc1ccc(-c2ccnc3cc(-c4ccc(Cl)cc4)nn23)cc1OC1CCCC1 CHEMBL602046 IC50 90.0 nM
COc1ccc(C2(c3ccc(OC)cc3)c3cc(O)ccc3-c3cccc(C#Cc4ccc(O)cc4)c32)cc1 CHEMBL4451141 IC50 90.0 nM
COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1 CHEMBL3628685 IC50 94.0 nM
CCc1nc(Nc2ccc(C(C)C(=O)O)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315275 IC50 96.0 nM
CCOc1cc2c(cc1OC)CCN(C=O)[C@H]2CCc1c[nH]c2cc(C)ccc12 CHEMBL4532140 IC50 98.0 nM
COc1c(OCCCCC(=O)O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4567905 IC50 99.0 nM
COc1c(OCCCCCCN2CCCC2)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4515248 IC50 99.0 nM
Fc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL599327 IC50 100.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cc(Cl)cc(Cl)c4)nn23)cc1OCC1CC1 CHEMBL598654 IC50 100.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccc(N5CCCCC5)c4)nn23)cc1OCC1CC1 CHEMBL598946 IC50 100.0 nM
CCOC(=O)c1c(NC(=O)Cc2ccccc2)sc2c1CCN(C(=O)OCC)C2 CHEMBL114535 IC50 100.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2)n2nc(C3CC3)nc12 CHEMBL4760414 IC50 100.0 nM
COc1ccc(-c2cccc(C(=O)O)c2)n2nc(C3(C(=O)NCC(C)C)CC3)nc12 CHEMBL4789407 IC50 100.0 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3(CCO)CC3)nc12 CHEMBL4756569 IC50 100.0 nM
COc1ccc(C2=NN(CCCCCNCC[C@@H](Oc3ccc(C(F)(F)F)cc3)c3ccccc3)C(=O)C3CC=CCC23)cc1OC CHEMBL499461 IC50 106.0 nM
COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1 CHEMBL3628786 IC50 108.0 nM
COc1ccc(-c2nc(C(F)(F)F)ncc2C(=O)Nc2ccncc2)cc1OC CHEMBL4282274 IC50 108.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCCCNc3c4c(nc5ccccc35)CCCC4)cnc21 CHEMBL4466312 IC50 108.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OC)c1OC CHEMBL3315073 IC50 110.0 nM
COC(=O)c1cccc(-c2ccc(OC)c3nc(C4CC4)nn23)c1 CHEMBL4755604 IC50 110.0 nM
COc1ccc(Cn2cnc(N)c3nc([C@@H](C)COc4cccc(F)c4)nc2-3)cc1OC1CCCC1 CHEMBL361104 Ki 114.7 nM
COc1ccccc1CNc1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CC(C)(C)OC3 CHEMBL1257655 IC50 119.0 nM
CN(C)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL597072 IC50 120.0 nM
CCC1CCc2c(sc(NC(=O)c3ccccc3[N+](=O)[O-])c2C(N)=O)C1 CHEMBL568004 pIC50 125.89 nM
CC(C)(C)C1CCc2c(sc(NC(=O)c3ccccc3[N+](=O)[O-])c2C(N)=O)C1 CHEMBL583841 pIC50 125.89 nM
CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NCc5ccncc5)ncnc4c23)CO1 CHEMBL1257537 IC50 128.0 nM
COc1cc2c(-c3cc(OCC4CC4)cc(OCC4CC4)c3)nc(OCCCO)nc2cc1OCCO CHEMBL96039 IC50 130.0 nM
COc1ccc(-c2ccnc3cc(-c4ccc(Br)cc4)nn23)cc1OC1CCCC1 CHEMBL600791 IC50 130.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4ccccc4)nn23)cc1OCC1CC1 CHEMBL604940 IC50 130.0 nM
CCOc1cc2c(cc1OC)CCN(C=O)[C@H]2CCc1c[nH]c2ccccc12 CHEMBL4543264 IC50 130.0 nM
COc1ccc(-c2cccc(C#N)c2)n2nc(C3(CO)CC3)nc12 CHEMBL4791895 IC50 130.0 nM
COC(=O)c1ccc(-c2ccc(OC)c3nc(C4(C(=O)NCC(C)C)CC4)nn23)cc1 CHEMBL4760926 IC50 130.0 nM
CCc1nc(Nc2ccc(-c3nnn[nH]3)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315272 IC50 132.0 nM
COc1ccc(CCNC(=O)c2cnc(SC)nc2N2CCOCC2)cc1OC CHEMBL4283606 IC50 136.0 nM
COc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1 CHEMBL420454 IC50 140.0 nM
COc1ccc(-c2ccnc3cc(-c4ccccc4Br)nn23)cc1OC1CCCC1 CHEMBL606171 IC50 140.0 nM
COc1ccc(/C=N/N(C)C(=O)c2ccccc2)cc1OC CHEMBL2172731 IC50 140.0 nM
COc1cc(OC)c2ccc(=O)oc2c1/C=C/[C@H]1C[C@@H](C=C(C)C)c2c(c3ccccc3n(C)c2=O)O1 CHEMBL3235992 IC50 140.0 nM
COc1cc2c(cc1OC)[C@H](Cc1c[nH]c3ccccc13)N(C=O)CC2 CHEMBL4466435 IC50 140.0 nM
CCNc1ncn(Cc2ccc(OC)c(OC3CCCC3)c2)c2nc(C(C)C)nc1-2 CHEMBL362652 Ki 141.0 nM
O=C(NC1CC1)c1nc2cccnn2c1-c1cc(F)c(Cl)c(F)c1 CHEMBL5283294 IC50 145.0 nM
O=C(c1cnccn1)N1CCN(CCCNc2nnc(-c3cccc([N+](=O)[O-])c3)c3c2cc2ccccn23)CC1 CHEMBL1090373 Ki 147.0 nM
COc1c(OCCCCCCCN2CCCC2)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4536071 IC50 148.0 nM
NC(=O)Nc1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL604721 IC50 150.0 nM
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCCCCNC(CCO)C(=O)O)c1 CHEMBL3327324 IC50 150.0 nM
COc1ccc([C@@H]2CNC(=O)[C@@H](Cc3cccc(C)c3)C2)cc1OC1CCCC1 CHEMBL3769962 IC50 150.0 nM
COc1ccc(-c2ccc(C(=O)O)c(CO)c2)n2nc(C3(C(=O)OCC(C)C)CC3)nc12 CHEMBL4750770 IC50 150.0 nM
COc1ccc([C@H]2CNC(=O)[C@H](Cc3cccc(C)c3)C2)cc1OC1CCCC1 CHEMBL4297287 IC50 150.0 nM
COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(C)(=O)=O)CC3)c12 CHEMBL3644501 IC50 151.0 nM
COCCOC(=O)c1cccc(-c2cc3nccc(-c4ccc(OC(F)F)c(OCC5CC5)c4)n3n2)c1 CHEMBL598906 IC50 160.0 nM
CCc1nc(Nc2ccc(NS(N)(=O)=O)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315274 IC50 160.0 nM
COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F CHEMBL313842 IC50 160.0 nM
CCOC(=O)c1c(C)nn(-c2ccc(N)cc2)c1C CHEMBL1230397 IC50 160.0 nM
COc1ccc(/C(C)=N\OCC(=O)N2CCOCC2)cc1OC1CCCC1 CHEMBL4853419 IC50 160.0 nM
COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@H]3CCN(S(C)(=O)=O)C3)c12 CHEMBL3644504 IC50 163.0 nM
COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@@H]3CCN(S(C)(=O)=O)C3)c12 CHEMBL3644503 IC50 163.0 nM
CC(C)C(=O)c1c(C(C)C)nn2ccccc12 CHEMBL19449 IC50 166.0 nM
CS(=O)(=O)Nc1ccc2oc3c(OC(F)F)ccc(C(=O)Nc4c(Cl)cncc4Cl)c3c2c1 CHEMBL4297520 IC50 166.0 nM
O=C(Nc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCCCNC2CCOC2=O)c1 CHEMBL3327327 IC50 170.0 nM
COC(=O)C1(c2nc3c(OC)ccc(-c4ccc5c(c4)COC5=O)n3n2)CC1 CHEMBL4741618 IC50 170.0 nM
CCCC(=O)c1cccc(-c2ccc(OC)c3nc(C4CC4)nn23)c1 CHEMBL4742306 IC50 170.0 nM
COc1ccc(-c2ccc(C(C)=O)cc2)n2nc(C3CC3)nc12 CHEMBL4757295 IC50 170.0 nM
CCOc1cc2c(cc1OC)CCN(C(C)=O)[C@H]2Cc1c[nH]c2ccccc12 CHEMBL4859162 IC50 170.0 nM
O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12 CHEMBL146095 AC50 170.0 nM
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F CHEMBL1750 AC50 170.0 nM
COc1ccc(C(=O)CC(C)C)cc1OC1CCOC1 CHEMBL456591 pIC50 177.83 nM
CCc1nn(C2CCCC2)c2c1CCn1c(-c3cccc(OC)c3)nnc1-2 CHEMBL218793 IC50 180.0 nM
O=C(CCc1ccccc1)c1ccc(OC(F)F)c(OC2CCOC2)c1 CHEMBL457663 IC50 180.0 nM
CCCCNC(=O)Cc1ccc(Nc2nc(-c3ccccc3)nc3c2S(=O)(=O)CCC3)cc1 CHEMBL2385756 IC50 180.0 nM
COc1cc(OC)c2ccc(=O)oc2c1/C=C/[C@@]1(C)C[C@@H](C=C(C)C)c2c(c3ccccc3n(C)c2=O)O1 CHEMBL5170835 IC50 180.0 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cccc(C(F)(F)F)c4)nn23)cc1OCC1CC1 CHEMBL598318 IC50 190.0 nM
CC1CN(CC(O)CO/N=C/c2ccc(OC(F)F)c(OC3CCCC3)c2)CC(C)O1 CHEMBL3585870 IC50 190.0 nM
CC1CN(NCC(O)CO/N=C/c2ccc(OC(F)F)c(OC3CCCC3)c2)CC(C)O1 CHEMBL3585872 IC50 190.0 nM
COCc1ncc(Cc2cnc3ccc(O)c(C(F)(F)F)c3c2)c2cc(OC)c(OC)cc12 CHEMBL3907937 IC50 194.0 nM
CCCCC(=O)c1ccc(OC)c(OC2CCOC2)c1 CHEMBL456573 pIC50 199.53 nM
COc1ccc(C(=S)Nc2c(Cl)cccc2Cl)cc1OC1CCCC1 CHEMBL517124 pIC50 199.53 nM
FC(F)Oc1ccc(-c2ccnc3cc(-c4cc(Cl)ccc4Cl)nn23)cc1OCC1CC1 CHEMBL596696 IC50 200.0 nM
OCc1ccc2c(c1C#Cc1ccc(O)cc1)C(c1ccc(O)cc1)(c1ccc(O)cc1)c1cc(O)ccc1-2 CHEMBL4444637 IC50 200.0 nM
COc1c(OCCCCCN2CCCC2)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4563050 IC50 200.0 nM
COc1ccc(-c2cccc3c2COC3=O)n2nc(C3CC3)nc12 CHEMBL4793156 IC50 200.0 nM
COc1c(O)cc2oc3cc4c(c(OCc5ccccn5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL5428117 IC50 203.0 nM
CCc1nc(Nc2ccc(F)cc2)nc(-c2ccc(Cl)s2)n1 CHEMBL3315262 IC50 207.0 nM
COc1ccc(/C=N/OCC(O)CNN2CC(C)OC(C)C2)cc1OC1CCCC1 CHEMBL3326090 IC50 210.0 nM
C[C@@H]1COCCN1c1nc(N2CCOC[C@@H]2C)nc2sc(-c3cc[nH]n3)nc12 CHEMBL4518369 IC50 210.0 nM
COc1ccc(-c2ccc3c(c2)C(=O)CC3)n2nc(C3CC3)nc12 CHEMBL4786389 IC50 210.0 nM
COc1ccc(-c2ccccc2)n2nc(C3CC3)nc12 CHEMBL4743465 IC50 210.0 nM
COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OC)c1OCC1CC1 CHEMBL3315074 IC50 212.0 nM
CCc1nc(Nc2ccc(C(=O)O)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315270 IC50 213.0 nM
CC(C)c1nc(Nc2ccc(C(=O)O)cc2)nc(-c2ccc(Cl)s2)n1 CHEMBL3315263 IC50 219.0 nM
COc1ccc(NC(=O)c2cnc(SC)nc2N2CCOCC2)cc1OC CHEMBL4284354 IC50 220.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 AC50 220.0 nM
COc1cc2c(-c3cc(OCC4CC4)cc(OCC4CC4)c3)nc(NCCCO)nc2cc1OCCO CHEMBL97785 IC50 230.0 nM
Oc1cc(O)c2cc(-c3cc(I)c(O)c4ncccc34)oc2c1 CHEMBL3735540 IC50 230.0 nM
COc1ccc([C@@H]2CNC(=O)C2)cc1OC1CCCC1 CHEMBL430893 IC50 231.0 nM
CCCc1ncc(Cc2cnc3ccc(O)c(C(F)(F)F)c3c2)c2cc(OC)c(OC)cc12 CHEMBL3974402 IC50 232.0 nM
CCN(C)c1nc2oc3c(NCc4cccnc4)ncnc3c2c2c1CCC(C)(C)C2 CHEMBL1830647 IC50 240.0 nM
COc1cc2c(cc1OC)[C@H](CCc1c[nH]c3cc(C)ccc13)N(C=O)CC2 CHEMBL4527894 IC50 240.0 nM
C=C1CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@@H](OC(=O)/C=C/c6ccc(O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2[C@H]1C CHEMBL3793675 IC50 245.0 nM
CC(C)=C[C@@H]1Oc2cc(O)ccc2-c2oc3c4c(cc(O)c3c(=O)c21)OC(C)(C)C=C4 CHEMBL4176617 IC50 250.0 nM
COc1cc2c(cc1OC)[C@H](CCc1c[nH]c3cc(F)ccc13)N(C=O)CC2 CHEMBL4592339 IC50 250.0 nM
CNc1cc(Nc2cccnc2OC)nc2c(C(=O)NC3CC3)cnn12 CHEMBL5415951 IC50 250.0 nM
CCc1nc(Nc2ccc(C(=O)O)cc2)nc(-c2ccc(Cl)s2)n1 CHEMBL3315261 IC50 251.0 nM
COc1ccc(C2=NN(C(C)C)C(=O)[C@@H]3CC=CC[C@H]23)cc1C#CC(N)=O CHEMBL4463356 pKd 251.19 nM
COc1ccc(C2=NN(CCCCCNCC[C@H](Oc3ccc(C(F)(F)F)cc3)c3ccccc3)C(=O)C3CC=CCC23)cc1OC CHEMBL454507 IC50 253.0 nM
CC(C)=CCc1c(O)cc2oc(-c3ccc(O)cc3O)c(CC=C(C)C)c(=O)c2c1O CHEMBL485777 IC50 260.0 nM
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O CHEMBL559 AC50 260.0 nM
O=C(O)c1ccc(Nc2nc(-c3ccc(Cl)cc3)nc(C3CC3)n2)cc1 CHEMBL3315266 IC50 268.0 nM
O=C1CCC(NC2=NC(C3CC3)NC(c3cccc(Cl)c3)=N2)CN1 CHEMBL3315267 IC50 268.0 nM
CC(C)=CCCC1(C)C=Cc2c(ccc(-c3oc4cc(O)cc(O)c4c(=O)c3CC=C(C)C)c2O)O1 CHEMBL4167451 IC50 270.0 nM
COc1cc2c(cc1OC)[C@H](CCc1c[nH]c3ccccc13)N(C=O)CC2 CHEMBL4520636 IC50 270.0 nM
CCOC(=O)c1c(C)nn(-c2ccccc2)c1C CHEMBL1794670 IC50 270.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)cnc21 CHEMBL4549577 IC50 271.0 nM
COc1ccc(-c2nc3c(c(Nc4ccc(CC(=O)O)cc4)n2)SCCC3)cc1 CHEMBL3112613 IC50 280.0 nM
COc1ccc(CNC(=O)c2ccc(OC)c(OC3CCCC3)c2)cc1 CHEMBL3628679 IC50 284.0 nM
CCOC(=O)N1CCc2c(sc(NC(=O)Cc3cccs3)c2C(=O)OC2CCCC2)C1 CHEMBL1923060 IC50 290.0 nM
COc1cccc2cc(-c3nc4c(c(Nc5ccc(CC(=O)O)cc5)n3)S(=O)(=O)CCC4)ccc12 CHEMBL3114943 IC50 290.0 nM
N#Cc1ccc(-c2nc3c(c(Nc4ccc(CC(=O)O)cc4)n2)SCCC3)cc1 CHEMBL3114926 IC50 290.0 nM
CCCCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1 CHEMBL418785 IC50 300.0 nM
COc1ccc(-c2nc3c(c(Nc4ccc(CC(=O)NCC(C)(C)C)cc4)n2)S(=O)(=O)CCC3)cc1F CHEMBL3114921 IC50 300.0 nM
COc1cc2c(cc1OC)[C@H](Cc1c[nH]c3ccc(C)cc13)N(C=O)CC2 CHEMBL4864866 IC50 300.0 nM
COc1c(O)cc2oc3cc4c(c(OCCCCCCC(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4846021 IC50 300.0 nM
O=C(NC1CC1)c1nn2c(c1-c1cc(F)c(Cl)cc1F)OC[C@@H](F)C2 CHEMBL4168265 IC50 306.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCCCCNc3c4c(nc5ccc(Cl)cc35)CCCC4)cnc21 CHEMBL4589577 IC50 308.0 nM
CC(C)=CCc1c(-c2ccc(O)cc2O)oc2c(CC=C(C)C)c(O)cc(O)c2c1=O CHEMBL518543 IC50 310.0 nM
CCC(=O)c1cccc(-c2ccc(OC)c3nc(C4CC4)nn23)c1 CHEMBL4741545 IC50 310.0 nM
N#CC(c1ccc(OC(F)F)c(OC2CCCC2)c1)c1ccc(Cl)nn1 CHEMBL5287106 IC50 310.0 nM
CC(C)(C)C1CCc2c(sc(NC(=O)c3ccncc3)c2C(N)=O)C1 CHEMBL576656 pIC50 316.23 nM
O=C1Nc2c(Cl)ccc(OCc3nn[nH]n3)c2C2(CCCCC2)N1 CHEMBL184861 IC50 320.0 nM
Oc1ccc2oc(-c3cc(I)c(O)c4ncccc34)cc2c1 CHEMBL3734974 IC50 320.0 nM
COc1cccc(OC[C@H](C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c-3n2)c1 CHEMBL444808 Ki 322.0 nM
COc1cccc2c1ncc1c(=O)n(-c3cccc(C)c3)c(=O)n(C3CCCC3)c12 CHEMBL3644499 IC50 338.0 nM
COc1ccc(-c2ccc(C(=O)O)c(CO)c2)n2nc(C3CC3)nc12 CHEMBL4743334 IC50 340.0 nM
COc1ccc(CNC(=O)c2ccc(OC)c(OCC3CC3)c2)cc1 CHEMBL3628681 IC50 342.0 nM
CCCC(=O)c1ccc(OC(F)F)c(OC2CCOCC2)c1 CHEMBL458297 pIC50 346.74 nM
COc1ccc(-c2nc(C(F)(F)F)ncc2C(=O)Nc2c(Cl)cncc2Cl)cc1OC CHEMBL4278921 IC50 360.0 nM
COc1cc2c(cc1OC)[C@H](Cc1c[nH]c3cccc(Cl)c13)N(C=O)CC2 CHEMBL4875765 IC50 360.0 nM
COc1cc2c(cc1OC)[C@H](Cc1c[nH]c3c(Cl)cccc13)N(C=O)CC2 CHEMBL4848137 IC50 360.0 nM
COc1ccc(C(=O)CCC(C)C)cc1OC1CCOC1 CHEMBL457215 IC50 380.0 nM
C=C(C)Cn1c(SCC(=O)c2cccs2)nc2sc3c(c2c1=O)CCCC3 CHEMBL3785098 IC50 380.0 nM
CNc1cc(Nc2cccc(-c3ccccc3)c2)nn2c(C(N)=O)cnc12 CHEMBL4291611 IC50 380.0 nM
COc1ccc(NC(=O)c2cnc(C(F)(F)F)nc2N2CCOCC2)cc1OC CHEMBL4295242 IC50 385.0 nM
CCOC(=O)c1cnc2c(cnn2CC)c1NN=C(C)C CHEMBL356388 IC50 390.0 nM
COc1cc2c(cc1OC)C(Cc1c[nH]c3ccccc13)N(C=O)CC2 CHEMBL4874067 IC50 390.0 nM
CCc1ncc(Cc2ccc3cccc(NC(=O)C(N)=O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3975984 IC50 398.0 nM
CCCC(=O)c1ccc(OC)c(OC2CCOC2)c1 CHEMBL456574 pIC50 398.11 nM
COc1ccc(C(=O)Nc2c(F)cccc2F)cc1OC1CCCCC1 CHEMBL45055 pIC50 398.11 nM
CC1(C)CCc2c(sc(NC(=O)c3ccccc3[N+](=O)[O-])c2C(N)=O)C1 CHEMBL584684 pIC50 398.11 nM
O=C(Nc1ccc(O)c2ncccc12)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL4447509 IC50 399.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3cc4ccccc4s3)nc3c2S(=O)(=O)CCC3)cc1 CHEMBL3114945 IC50 400.0 nM
CC(C)=CC1Oc2cc(O)ccc2-c2oc3cc(O)cc(O)c3c(=O)c21 CHEMBL4164003 IC50 400.0 nM
CC(C)=CC1CC(C)(CCO)Oc2c1c(=O)n(C)c1ncccc21 CHEMBL5208713 IC50 400.0 nM
CC(C)(C)C(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1 CHEMBL456590 pIC50 407.38 nM
O=C(O)Cc1ccc(Nc2nc(-c3ccc(Cl)cc3)nc3c2SCCC3)cc1 CHEMBL3114925 IC50 420.0 nM
COc1c(O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL561643 IC50 420.0 nM
O=C(Nc1cc(I)c(O)c2ncccc12)c1ccc(OC(F)F)c(OCC2CC2)c1 CHEMBL4434751 IC50 426.0 nM
COc1ccc(-c2nc3c(c(Nc4ccc(CC(=O)O)cc4)n2)SCCC3)cc1Cl CHEMBL3114933 IC50 430.0 nM
CCc1ncc(Cc2ccc3cccc(O)c3n2)c2cc(OC)c(OC)cc12 CHEMBL3938531 IC50 439.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3ccc4c(F)cccc4c3)nc3c2S(=O)(=O)CCC3)cc1 CHEMBL3114944 IC50 440.0 nM
COc1ccc(-c2nc3c(c(Nc4ccc(CC(=O)O)cc4)n2)SCCC3)cc1F CHEMBL4789722 IC50 440.0 nM
O=C(c1nc2cccnc2n1-c1ccc(Cl)c(Cl)c1)N1CCC1 CHEMBL4762079 IC50 450.0 nM
O=C1Nc2c(Cl)cc(-c3ccc(C(=O)O)cc3)cc2C2(CCCCC2)N1 CHEMBL185304 IC50 470.0 nM
CC1CN(C(=O)CCO/N=C/c2ccc(OC(F)F)c(OC3CCCC3)c2)CC(C)O1 CHEMBL3585876 IC50 470.0 nM
COc1ccc(/C(C)=N\OCC(=O)N2CC(C)OC(C)C2)cc1OC1CCCC1 CHEMBL4862157 IC50 470.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCCCCNc3c4c(nc5ccccc35)CCCC4)cnc21 CHEMBL4576029 IC50 477.0 nM
COc1c(OCC(=O)O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4434646 IC50 480.0 nM
CCCn1c(SCC(=O)c2cccs2)nc2sc3c(c2c1=O)CCCC3 CHEMBL3785585 IC50 486.0 nM
COc1ccc(C(=O)Nc2ccc(O)c3ncccc23)cc1OC1CCCC1 CHEMBL4586148 IC50 492.0 nM
COc1c(O)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4855047 IC50 494.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCCCCCNc3c4c(nc5ccccc35)CCCC4)cnc21 CHEMBL4582090 IC50 501.0 nM
O=C(CCc1ccccc1)c1ccc(OC(F)F)c(OC(F)F)c1 CHEMBL456617 pIC50 501.19 nM
CC1CCc2c(sc(NC(=O)c3ccccc3[N+](=O)[O-])c2C(N)=O)C1 CHEMBL568465 pIC50 501.19 nM
COc1cc2c(cc1OC)C(CCc1c[nH]c3ccccc13)N(C=O)CC2 CHEMBL4556365 IC50 510.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3ccc4ccccc4c3)nc3c2S(=O)(=O)CCC3)cc1 CHEMBL3114941 IC50 520.0 nM
CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCC3CC3)cc2n1 CHEMBL97866 IC50 540.0 nM
C=C1CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@@H](OC(=O)/C=C\c6ccc(O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2[C@H]1C CHEMBL3793522 IC50 542.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3ccccc3)nc3c2S(=O)(=O)CCC3)cc1 CHEMBL2385749 IC50 550.0 nM
COc1cc2c(cc1OC)[C@H](Cc1c[nH]c3cc(Cl)ccc13)N(C=O)CC2 CHEMBL4865887 IC50 550.0 nM
Cc1cc(C#N)c(F)cc1-c1c(C(=O)NC2CC2)nn2c1OCC(F)C2 CHEMBL4176593 IC50 558.0 nM
COc1ccc(-c2nc3c(c(Nc4cc(F)c(CC(=O)O)cc4Cl)n2)S(=O)(=O)CCC3)cc1F CHEMBL3114953 IC50 560.0 nM
COc1ccc(-c2nc3c(c(Nc4cc(F)c(CC(=O)O)c(F)c4)n2)S(=O)(=O)CCC3)cc1F CHEMBL3114950 IC50 580.0 nM
Nc1ncc2cc(-c3nccnc3OC3CN(c4ccc5ccccc5n4)C3)ccc2n1 CHEMBL3356680 IC50 581.0 nM
COc1ccc(Cn2cnc(N)c3nc([C@@H](C)COc4ccccc4)nc2-3)cc1OC1CCCC1 CHEMBL179868 Ki 590.0 nM
COc1ccc(C(=O)Nc2cc(I)c(O)c3ncccc23)cc1OC1CCCC1 CHEMBL4445263 IC50 597.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3cc4ccccc4s3)nc3c2S(=O)(=O)CCC3)cc1F CHEMBL3114958 IC50 600.0 nM
COc1ccc(-c2nc3c(c(Nc4cc(Cl)c(CC(=O)O)cc4Cl)n2)S(=O)(=O)CCC3)cc1F CHEMBL3114952 IC50 600.0 nM
CCc1nc(Nc2ccc(C(C)(C)C(=O)O)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315276 IC50 600.0 nM
COc1ccc(-c2cccc(C(=O)O)c2)n2nc(C3CC3)nc12 CHEMBL4748344 IC50 600.0 nM
CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NCCN5CCOCC5)ncnc4c23)CO1 CHEMBL1258123 IC50 604.0 nM
COc1cc2c(cc1OC)C(Cc1c[nH]c3cc(Cl)ccc13)N(C=O)CC2 CHEMBL4855517 IC50 610.0 nM
COc1ccc2[nH]c(C)c(C[C@H]3c4cc(OC)c(OC)cc4CCN3C=O)c2c1 CHEMBL4876519 IC50 610.0 nM
N#Cc1c(C2CCCC2)c2ccc(NCc3ccc(F)cn3)cc2n(CC2CCCC2)c1=O CHEMBL5395569 IC50 610.0 nM
COc1cccc2c1ncc1c(=O)n(-c3cc(C)cs3)c(=O)n(C3CCCC3)c12 CHEMBL3644498 IC50 616.0 nM
COc1ccc(-c2nc3c(c(Nc4ccc(CC(=O)O)c(F)c4)n2)S(=O)(=O)CCC3)cc1F CHEMBL3114948 IC50 620.0 nM
Clc1ncnc2ccccc12 CHEMBL2172707 IC50 622.0 nM
COc1c(OCCCCN2CCCC2)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 CHEMBL4524406 IC50 622.0 nM
CC(C)=CCc1c(O)cc(O)c2c(=O)cc(-c3ccc(O)cc3)oc12 CHEMBL371562 IC50 630.0 nM
CCOc1cc2c(cc1OC)CCN(C=O)[C@H]2Cc1c[nH]c2c(Cl)cccc12 CHEMBL4863785 IC50 630.0 nM
CCOc1cc2c(cc1OC)CCN(C=O)[C@H]2Cc1c(C)[nH]c2ccc(OC)cc12 CHEMBL4860020 IC50 630.0 nM
O=C(CCCc1ccccc1)c1ccc(OC(F)F)c(OC2CCOC2)c1 CHEMBL458933 pIC50 630.96 nM
CCCCOc1cc(C[C@@H]2CNC(=O)N2)ccc1OC CHEMBL1229585 IC50 631.0 nM
COc1ccc(C(=O)Nc2ccccc2Cl)cc1OC CHEMBL45854 pIC50 645.65 nM
CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(O)cc2n1 CHEMBL95715 IC50 650.0 nM
CCOC(=O)C1=CN(Cc2ccc(OC)c(OC)c2)C=C(C(=O)OCC)C1c1c[nH]c2ccccc12 CHEMBL2315889 IC50 650.0 nM
COc1ccc(/C=N/N2CCOCC2)cc1OC1CCCC1 CHEMBL3326083 IC50 660.0 nM
O=C(CC1CCCCC1)c1ccc(OC(F)F)c(OC2CCOC2)c1 CHEMBL458932 pIC50 660.69 nM
COc1ccc(/C=N/OCC(=O)N2CC(C)OC(C)C2)cc1OC1CCCC1 CHEMBL570803 IC50 670.0 nM
O=C(O)C[C@H](O)C[C@H](O)/C=C/c1c(C2CC2)nc2ccccc2c1-c1ccc(F)cc1 CHEMBL1201753 AC50 670.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3cccc(F)c3)nc3c2SCCC3)cc1 CHEMBL3114923 IC50 680.0 nM
CCc1nc(Nc2ccc(CC(=O)O)cc2)nc(-c2cccc(Cl)c2)n1 CHEMBL3315269 IC50 681.0 nM
NC(=O)c1ccc(-c2cc(Cl)c3c(c2)C2(CCCCC2)NC(=O)N3)cc1 CHEMBL185296 IC50 690.0 nM
C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc(F)cc1)c1ccc(Cl)cc1 CHEMBL4644729 IC50 699.0 nM
CCSc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1 CHEMBL99101 IC50 700.0 nM
Cn1c([S+](C)[O-])nc(-c2ccc(F)cc2)c1-c1ccnc(N)c1 CHEMBL4075428 IC50 700.0 nM
COc1cc2c(cc1OCC1CC1)[C@H](CCc1c[nH]c3cc(C)ccc13)N(C=O)CC2 CHEMBL4443701 IC50 700.0 nM
COc1ccc(/C=N/N(C)S(=O)(=O)c2cc3c(cc2C)OCO3)cc1OC CHEMBL4746166 IC50 700.0 nM
CCCCC(=O)c1ccc(OC)c(OC2CCOCC2)c1 CHEMBL443679 IC50 720.0 nM
COc1ccc(/C(C)=N\OCC(O)CN2CCOCC2)cc1OC1CCCC1 CHEMBL4852484 IC50 720.0 nM
O=C(O)Cc1ccc(CNc2nc(-c3cccc(Cl)c3)nc(C3CC3)n2)cc1 CHEMBL3315258 IC50 726.0 nM
CCc1nc(Nc2ccc(CC(=O)O)cc2)nc(-c2ccc(F)cc2)n1 CHEMBL3315255 IC50 727.0 nM
O=C1Nc2c(Cl)cc(-c3cccc(C(=O)O)c3)cc2C2(CCCCC2)N1 CHEMBL427505 IC50 740.0 nM
Oc1ccc(-c2cc3cc(I)cc(I)c3o2)c2cccnc12 CHEMBL3735115 IC50 750.0 nM
C=CCc1c(C)nc(-c2ccc(OC)s2)nc1Nc1ccc(C(=O)O)cc1 CHEMBL1782298 IC50 760.0 nM
CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2 CHEMBL1075 AC50 770.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3ccc(-c4ccccc4)cc3)nc3c2S(=O)(=O)CCC3)cc1 CHEMBL3114942 IC50 790.0 nM
CN(C)c1ccc(-c2nc3c(c(Nc4ccc(CC(=O)O)cc4)n2)SCCC3)cc1 CHEMBL3114928 IC50 790.0 nM
COc1cc2nc(C)nc(-c3cc(OCC4CC4)cc(OCC4CC4)c3)c2cc1OC CHEMBL96034 IC50 800.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc([S+](C)[O-])n2C)ccn1 CHEMBL1773422 IC50 800.0 nM
CC1CN(C(=O)CO/N=C/c2ccc(OC(F)F)c(OC3CCCC3)c2)CC(C)O1 CHEMBL3585874 IC50 800.0 nM
O=C(O)Cc1ccc(Nc2nc(-c3ccc4ccccc4c3)nc3c2S(=O)(=O)CCC3)cc1F CHEMBL3114957 IC50 810.0 nM
CCOc1cc2c(cc1OC)CCN(C=O)[C@H]2Cc1c[nH]c2cccc(Cl)c12 CHEMBL4867813 IC50 810.0 nM
Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1 CHEMBL268501 AC50 810.0 nM
O=C1Nc2c(Cl)ccc(OCc3noc(O)n3)c2C2(CCCCC2)N1 CHEMBL182536 IC50 820.0 nM
COc1cc2c(cc1OCC1CC1)[C@H](CCc1c[nH]c3ccccc13)N(C=O)CC2 CHEMBL4536368 IC50 820.0 nM
COc1cccc2c1ncc1c(=O)n(-c3ccc4c(c3)OCO4)c(=O)n(C3CCCC3)c12 CHEMBL3644500 IC50 827.0 nM
CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2ccc(OCCO)cc2n1 CHEMBL318444 IC50 850.0 nM
O=C(O)Cc1ccc(CNc2nc(-c3ccc(Cl)cc3)nc(C3CC3)n2)cc1 CHEMBL3315257 IC50 859.0 nM
CC(=O)c1ccc(-c2nc3c(c(Nc4ccc(CC(=O)O)cc4)n2)S(=O)(=O)CCC3)cc1 CHEMBL3114936 IC50 860.0 nM
CCc1nc(Nc2ccc(CC(=O)O)cc2)nc(-c2ccc(Cl)s2)n1 CHEMBL3315248 IC50 865.0 nM
CC1(C)C=Cc2c(c3c(c4c(=O)cc(-c5ccc(O)cc5O)oc24)OC(C)(C)CC3)O1 CHEMBL4160605 IC50 870.0 nM
O=C(c1nc2cccnc2n1-c1ccc(Cl)c(Cl)c1)N1CC(F)(F)C1 CHEMBL4783529 IC50 880.0 nM
CC(C)c1nc(Nc2ccc(F)cc2)nc(-c2ccc(Cl)s2)n1 CHEMBL3315264 IC50 886.0 nM
Oc1ccc2cc(-c3cc(I)c(O)c4ncccc34)oc2c1 CHEMBL3735548 IC50 890.0 nM
COc1cc2c(cc1OC)[C@H](Cc1c[nH]c3ccccc13)N(C(C)=O)CC2 CHEMBL4859738 IC50 890.0 nM
NC(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)NO)n1 CHEMBL226630 IC50 900.0 nM
CC(C)=CCc1c(-c2ccc(O)cc2O)oc2c3c(cc(O)c2c1=O)OC(C)(C)C=C3 CHEMBL464006 IC50 900.0 nM
CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c2cc(OC)c(OC)cc21 CHEMBL404216 IC50 900.0 nM
C=CCc1c(-c2cccc(NS(=O)(=O)c3ccccc3)c2)oc(=O)c2cc(F)ccc12 CHEMBL4856088 IC50 900.0 nM
CCn1ncc2c(NC3CCCCC3)c(C(=O)NCCCCCCCNc3c4c(nc5ccc(Cl)cc35)CCCC4)cnc21 CHEMBL4469202 IC50 934.0 nM
CC1=C(C(=O)O[C@H](C)c2ccccc2)C(c2ccc3c(cnn3C)c2)C(C(=O)O[C@H](C)c2ccccc2)=C(C)N1 CHEMBL5180169 IC50 948.0 nM
COc1cc2ccc(=O)oc2c2c1OC(C)(C)C=C2 CHEMBL529210 IC50 960.0 nM
Oc1ccc2oc(-c3cc(Cl)c(O)c4ncccc34)cc2c1 CHEMBL3736201 IC50 960.0 nM
C[C@@H]1COCCN1c1nc(N2CCOC[C@@H]2C)cc2sc(-c3cc[nH]n3)nc12 CHEMBL5400858 IC50 960.0 nM
C=C(C)Cn1c(SCC(=O)c2ccccc2)nc2sc3c(c2c1=O)CCCC3 CHEMBL1334234 IC50 965.0 nM
Nc1nc(Cl)nc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O1 CHEMBL1619 AC50 970.0 nM
C=CCc1c(C)nc(-c2ccsc2)nc1Nc1ccc(C(=O)O)cc1 CHEMBL1782290 IC50 990.0 nM