Cc1oc(-c2ccccc2)nc1CN1C[C@H](C(=O)NCc2cccc(N)n2)C[C@@H](c2ccccc2)C1 CHEMBL1780094 IC50 0.12 nM
Nc1nc(C(F)(F)F)nc2c1nnn2C[C@H]1CN(Cc2nccs2)CCO1 CHEMBL5169811 IC50 0.3 nM
Cc1cccc(CNC(=O)[C@@H]2C[C@@H](c3ccccc3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1779987 IC50 0.9 nM
Nc1nc(C2CC2)nc2c1nnn2C[C@H]1CN(Cc2nccs2)CCO1 CHEMBL2070733 IC50 0.9 nM
CC[C@H]1C[C@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780096 IC50 0.955 nM
Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1 CHEMBL2070735 IC50 1.3 nM
Nc1nc(C(F)(F)F)nc2c1nnn2C[C@H]1CN(Cc2ccccn2)CCO1 CHEMBL2070732 IC50 1.6 nM
COC[C@@H]1C[C@@H](C(=O)NCC2CCOCC2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780085 IC50 1.96 nM
CC[C@@H]1C[C@@H](C(=O)NC[C@H]2CCCO2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780116 IC50 2.91 nM
COC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1779988 IC50 3.2 nM
Nc1nc(C2CC2)nc2c1nnn2CC1OCCc2ccccc21 CHEMBL2070914 IC50 3.63 nM
Cc1cccc(CNC(=O)[C@H]2C[C@H](c3nc(C)no3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1780100 IC50 3.86 nM
Cc1cccc(CNC(=O)[C@@H]2C[C@@H](c3nc(C)no3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1780089 IC50 3.9 nM
CCc1csc(CN2CCO[C@@H](Cn3nnc4c(N)nc(C)nc43)C2)n1 CHEMBL2070736 IC50 4.2 nM
COC[C@H]1C[C@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780097 IC50 4.3 nM
COC[C@@H]1C[C@@H](C(=O)NC[C@H]2CCCO2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780105 IC50 4.36 nM
CC[C@@H]1C[C@@H](C(=O)NCc2cccc(N)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780111 IC50 4.42 nM
Cc1cccc(CNC(=O)C2CN(Cc3nc(-c4ccccc4)oc3C)Cc3ccccc32)n1 CHEMBL1779976 IC50 5.0 nM
CC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1779984 IC50 6.0 nM
CCC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1779985 IC50 6.0 nM
CC(C)(C)c1cc(Cn2nnc3c(N)nc(C4CC4)nc32)n[nH]1 CHEMBL2070935 IC50 6.79 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1cc(C2CC2)n[nH]1 CHEMBL2070604 IC50 6.8 nM
CC(=O)O[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1779990 IC50 7.0 nM
CC[C@@H]1C[C@@H](C(=O)NCC2CCOCC2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780084 IC50 7.3 nM
Nc1nc(C2CC2)nc2c1nnn2CC1CCCCO1 CHEMBL2070595 IC50 10.0 nM
Nc1nc(CSc2ccccc2)nc2c1nnn2CC1CCCCO1 CHEMBL2070901 IC50 12.1 nM
COC[C@@H]1C[C@@H](C(=O)NCC2CCOCC2)CN(Cc2nc(-c3ccncn3)[nH]c2C)C1 CHEMBL1780087 IC50 13.0 nM
Cc1nc(-c2nc(N)c3nnn(CC4CCCCO4)c3n2)cs1 CHEMBL2070907 IC50 13.1 nM
Nc1nc(C(F)(F)F)nc2c1nnn2C[C@H]1CCCO1 CHEMBL2070592 IC50 14.0 nM
Nc1nc(C(F)(F)F)nc2c1nnn2CC1CCCCO1 CHEMBL2070591 IC50 14.0 nM
CCCC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1779986 IC50 15.0 nM
COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC CHEMBL4128481 IC50 15.5 nM
CC[C@@H]1C[C@@H](C(=O)NCc2cccc(N)n2)CN(Cc2nc(N3CCOCC3)oc2C)C1 CHEMBL1780086 IC50 16.5 nM
Nc1nc(-c2cccs2)nc2c1nnn2CC1CCCCO1 CHEMBL2070769 IC50 17.1 nM
Nc1nc(COc2cccc(F)c2)nc2c1nnn2CC1CCCO1 CHEMBL2070912 IC50 17.1 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1ccc2c(c1)CCO2 CHEMBL2070919 IC50 17.1 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1ccc2c(c1)OCCO2 CHEMBL2070932 IC50 17.7 nM
Cc1nc(N)c2nnn(C[C@H]3CN(Cc4cc(F)cc(F)c4)CCO3)c2n1 CHEMBL2070737 IC50 19.0 nM
CC[C@@H]1C[C@@H](C(=O)NC[C@@H]2CCCO2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780102 IC50 19.6 nM
CC(C)(C)OC(=O)N1CCCCC1Cn1nnc2c(N)nc(C3CC3)nc21 CHEMBL2070933 IC50 21.4 nM
CCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070773 IC50 21.6 nM
Cc1ccnc(N2CCCC(Cn3nnc4c(N)nc(C5CC5)nc43)C2)n1 CHEMBL2070729 IC50 23.0 nM
Nc1nc(C2CC2)nc2c1nnn2C[C@H]1CN(Cc2ncccn2)CCO1 CHEMBL2070734 IC50 23.0 nM
Nc1nc(C2CC2)nc2c1nnn2C[C@H]1CCCO1 CHEMBL2070600 IC50 25.0 nM
Cc1ccn2cc(Cn3nnc4c(N)nc(C5CC5)nc43)nc2c1 CHEMBL2070916 IC50 25.5 nM
CC[C@@H]1C[C@@H](C(=O)NC[C@H]2CCCO2)CN(Cc2nc(-c3ccncn3)[nH]c2C)C1 CHEMBL1780090 IC50 26.0 nM
CC[C@@H]1C[C@@H](C(=O)NC[C@@H]2CCCO2)CN(Cc2nc(-c3ccncn3)[nH]c2C)C1 CHEMBL1780104 IC50 26.2 nM
CN1Cc2ccccc2CC1Cn1nnc2c(N)nc(C3CC3)nc21 CHEMBL2070925 IC50 31.5 nM
CC(c1ccc2[nH]ccc2c1)n1nnc2c(N)nc(C3CC3)nc21 CHEMBL2070920 IC50 31.7 nM
Cc1noc([C@@H]2C[C@@H](C(=O)NC[C@@H]3CCCO3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1780103 IC50 35.2 nM
Cc1cn2cc(Cn3nnc4c(N)nc(C5CC5)nc43)nc2s1 CHEMBL2070927 IC50 38.8 nM
CCCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070768 IC50 39.2 nM
Cc1cccc(CNC(=O)[C@@H]2C[C@@H](C)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1779983 IC50 40.0 nM
Nc1nc(C2CC2)nc2c1nnn2CC1CN(Cc2ccccc2)CCO1 CHEMBL2070731 IC50 41.0 nM
COCC1CC(C(=O)NC[C@H]2CCCO2)CN(Cc2nc(N3CCOCC3)oc2C)C1 CHEMBL1777837 IC50 43.0 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1nc2ccccc2c(=O)[nH]1 CHEMBL2070922 IC50 43.9 nM
COC[C@@H]1C[C@@H](C(=O)NCC2CCOCC2)CN(Cc2nc(N3CCOCC3)oc2C)C1 CHEMBL1780118 IC50 44.1 nM
Cc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070594 IC50 45.0 nM
Cc1cccc(CC(C)n2nnc3c(N)nc(C4CC4)nc32)n1 CHEMBL2070926 IC50 48.4 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1cnn(-c2ccccc2)n1 CHEMBL2070921 IC50 52.4 nM
Cc1cccn2cc(Cn3nnc4c(N)nc(C5CC5)nc43)nc12 CHEMBL2070934 IC50 53.8 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1nnc(-c2ccccc2)[nH]1 CHEMBL2070917 IC50 55.1 nM
Cc1oc(-c2ccccc2)nc1CN1CCC[C@@H](C(=O)NCc2cccc(N)n2)C1 CHEMBL1780091 IC50 58.0 nM
Nc1nc(Cc2ccccc2)nc2c1nnn2CC1CCCCO1 CHEMBL2070899 IC50 61.2 nM
COC[C@@H]1C[C@@H](C(=O)NC[C@H]2CCCO2)CN(Cc2nc(N3CCOCC3)oc2C)C1 CHEMBL1780088 IC50 65.0 nM
Cc1cccc(CNC(=O)[C@H]2C[C@H](c3nnc(C)o3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1780101 IC50 65.9 nM
Cc1cccc(CNC(=O)[C@@H]2C[C@@H](c3nnc(C)o3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1780093 IC50 66.0 nM
COC(=O)Cc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070770 IC50 70.7 nM
CC(C)CCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070898 IC50 72.7 nM
C[C@@H](C1CCCCC1)n1nnc2c(N)nc(C3CC3)nc21 CHEMBL2070923 IC50 74.6 nM
Nc1nc(CC(=O)O)nc2c1nnn2CC1CCCCO1 CHEMBL2070906 IC50 77.4 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1ccc(C(F)(F)F)cc1 CHEMBL2070929 IC50 78.4 nM
Cc1ncsc1CCn1nnc2c(N)nc(C3CC3)nc21 CHEMBL2070918 IC50 79.4 nM
CC(C)S(=O)(=O)Cc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070597 IC50 84.0 nM
Nc1nc(-c2ccco2)nc2c1nnn2CC1CCCCO1 CHEMBL2070771 IC50 84.4 nM
Nc1nc(C2CC2)nc2c1nnn2Cc1ccc(Cl)cc1 CHEMBL2070603 IC50 86.0 nM
Nc1nc(Cc2cccs2)nc2c1nnn2CC1CCCCO1 CHEMBL2070775 IC50 87.2 nM
CC(C)c1nc(NC(CN2CCCCC2)c2ccccc2)c2nnn(Cc3ccccc3)c2n1 CHEMBL2070589 IC50 89.0 nM
COc1ccc(Cn2nnc3c(N)nc(C#N)nc32)cc1 CHEMBL2070766 IC50 90.7 nM
COCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070596 IC50 91.0 nM
CCc1cnc(N2CC[C@@H](Cn3nnc4c(N)nc(C5CC5)nc43)C2)nc1 CHEMBL2070609 IC50 92.0 nM
CCc1nc(Cn2nnc3c(N)nc(C4CC4)nc32)cs1 CHEMBL2070606 IC50 93.0 nM
CCNC(=O)O[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1779991 IC50 120.0 nM
CC(=O)OCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070903 IC50 125.0 nM
CC(C)n1cc(Cn2nnc3c(N)nc(C4CC4)nc32)cn1 CHEMBL2070605 IC50 136.0 nM
Nc1nc(C2CC2)nc2c1nnn2CCSCc1ccco1 CHEMBL2070924 IC50 136.0 nM
Nc1nc(C2CC2)nc2c1nnn2CC1CCCOC1 CHEMBL2070601 IC50 150.0 nM
Nc1nc(-c2ccccc2)nc2c1nnn2CC1CCCCO1 CHEMBL2070598 IC50 160.0 nM
Cc1oc(-c2ccccc2)nc1CN1CCC[C@@H](C(=O)NC[C@H]2CCCO2)C1 CHEMBL1780092 IC50 166.0 nM
CC[C@@H]1C[C@@H](C(=O)NCC2CCOCC2)CN(Cc2nc(N3CCOCC3)oc2C)C1 CHEMBL1780112 IC50 168.0 nM
CSCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070902 IC50 177.0 nM
N#CCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070909 IC50 182.0 nM
CC(C)Cc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070900 IC50 186.0 nM
Nc1nc(C2CC2)nc2c1nnn2C[C@@H]1CCN(Cc2nccs2)C1 CHEMBL2070610 IC50 206.0 nM
Nc1nc(C2CC2)nc2c1nnn2CC1(c2ccccc2)CCOCC1 CHEMBL2070931 IC50 225.0 nM
CCCCc1nc(N)c2nnn(CC3CCCCO3)c2n1 CHEMBL2070897 IC50 228.0 nM
Cc1cccc(CNC(=O)C2CCCN(Cc3nc(-c4ccccc4)oc3C)C2)n1 CHEMBL1779978 IC50 240.0 nM
Nc1nc(C2CCCCC2)nc2c1nnn2CC1CCCCO1 CHEMBL2070599 IC50 243.0 nM
Nc1nc(C2CCC2)nc2c1nnn2CC1CCCCO1 CHEMBL2070774 IC50 247.0 nM
Nc1nc(C2CCCO2)nc2c1nnn2CC1CCCCO1 CHEMBL2070911 IC50 250.0 nM
COc1ccc(Cn2nnc3c(N)nc(C(N)=O)nc32)cc1 CHEMBL2070767 IC50 252.0 nM
Nc1nc(Cc2ccsc2)nc2c1nnn2CC1CCCCO1 CHEMBL2070895 IC50 254.0 nM
COCc1nc(N)c2nnn(C[C@H]3CCCO3)c2n1 CHEMBL2070913 IC50 281.0 nM
Cc1oc(-c2ccccc2)nc1CN1CCC[C@@H](C(=O)NC[C@@H]2CCCO2)C1 CHEMBL1780115 IC50 284.0 nM
Nc1nc(CC2CC2)nc2c1nnn2CC1CCCCO1 CHEMBL2070896 IC50 319.0 nM
Nc1nc(-c2cccnc2)nc2c1nnn2CC1CCCCO1 CHEMBL2070772 IC50 331.0 nM
Cc1cccc(CNC(=O)C2(F)CN(Cc3nc(-c4ccccc4)oc3C)Cc3ccccc32)n1 CHEMBL1779977 IC50 370.0 nM
Cc1cc(-c2nc(N)c3nnn(CC4CCCCO4)c3n2)no1 CHEMBL2070908 IC50 388.0 nM
CCCCN1CC(Cn2nnc3c(N)nc(C4CC4)nc32)OCC1=O CHEMBL2070930 IC50 455.0 nM
Cc1ccn2cc(Cn3nnc4c(N)nc(C5CC5)nc43)nc2n1 CHEMBL2070928 IC50 458.0 nM
Cc1oc(-c2ccccc2)nc1CN1CCCC(C(=O)NCC2CCOCC2)C1 CHEMBL1780099 IC50 516.0 nM
Nc1nc(Cn2ccnc2)nc2c1nnn2CC1CCCCO1 CHEMBL2070905 IC50 516.0 nM
Cn1cc(CCn2nnc3c(N)nc(C4CC4)nc32)cn1 CHEMBL2070915 IC50 551.0 nM
CC[C@H]1C[C@@H](C(=O)NC[C@H]2CCCO2)CN(Cc2nc(-c3ccccc3)oc2C)C1 CHEMBL1780117 IC50 675.0 nM
CN(C)CCNc1nc(C(F)(F)F)nc2c1nnn2CC1CCCCO1 CHEMBL2070590 IC50 703.0 nM
CC[C@@H]1C[C@@H](C(=O)NC[C@@H]2CCCO2)CN(Cc2nc(N3CCOCC3)oc2C)C1 CHEMBL1780108 IC50 707.0 nM
Nc1nc(CO)nc2c1nnn2CC1CCCCO1 CHEMBL2070904 IC50 773.0 nM
Nc1nc(C2CC2)nc2c1nnn2CC1CCOCC1 CHEMBL2070602 IC50 925.0 nM