COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 CHEMBL3360415 IC50 0.6 nM
O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCCC1 CHEMBL572934 IC50 0.8 nM
C[C@@H]1CN(Cc2ccc(F)cc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179099 IC50 0.9 nM
O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCOCC1 CHEMBL2179093 IC50 1.0 nM
COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3C(C)C)c(=O)[nH]2)cc1 CHEMBL3360419 IC50 1.05 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc(F)cc1 CHEMBL3360421 IC50 1.1 nM
C[C@@H]1CN(Cc2cccc(F)c2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2177125 IC50 1.2 nM
COc1cc2c(cc1C(=O)N(C)C)[nH]c(=O)c1cnc(C3CCCCC3)n12 CHEMBL3676170 IC50 1.2 nM
CC[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179096 IC50 1.7 nM
C[C@@H]1CN(Cc2ccc3nccnc3c2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL583914 pIC50 1.778 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2[nH]ncc2c1 CHEMBL4638644 IC50 1.8 nM
C[C@H]1CN(Cc2ccc3nccnc3c2)C[C@@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL565667 IC50 1.9 nM
Cn1cc(-c2ccc(F)cc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cn1 CHEMBL3693832 IC50 2.0 nM
CCc1ccc2c(c1)[nH]c(=O)c1cnc(CCC(=O)O)n12 CHEMBL3676175 IC50 2.0 nM
O=C(O)CCc1ncc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n12 CHEMBL3676176 IC50 2.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2[nH]cnc2c1 CHEMBL4642683 IC50 2.0 nM
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 CHEMBL562318 Activity 2.1 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2nccn2c1 CHEMBL4640285 IC50 2.1 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ccc3ccccc3n2)C1 CHEMBL3938847 IC50 2.24 nM
CC1CN(Cc2ccc3nccnc3c2)CC1c1nc(O)c2cnn(C3CCCC3)c2n1 CHEMBL4249954 IC50 2.8 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cnc3ccccc3n2)C1 CHEMBL3964410 IC50 2.94 nM
COc1ccc(NC(=O)[C@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 CHEMBL3360416 IC50 3.0 nM
Cc1nnc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)[nH]1 CHEMBL3693831 IC50 3.0 nM
CN(C)C(=O)c1cc2[nH]c(=O)c3cnc(C4CCCCC4)n3c2cc1Cl CHEMBL3676172 IC50 3.0 nM
O=C(O)CCc1ncc2c(=O)[nH]c3cc(Br)ccc3n12 CHEMBL3676174 IC50 3.0 nM
CCCC1CN(CC(=O)N2CCc3ccccc32)Cc2c1[nH]c(=O)c(C#N)c2-c1ccc(C)cc1 CHEMBL5205373 IC50 3.0 nM
COc1ccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cc1 CHEMBL2179100 IC50 3.4 nM
CCOc1cc2c(cc1C(=O)N(C)C)[nH]c(=O)c1cnc(C3CCCCC3)n12 CHEMBL3676171 IC50 3.4 nM
Cc1ccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cn1 CHEMBL2179102 IC50 3.8 nM
Cc1cc(C)nc(OC2CN(C(C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)n1 CHEMBL3924370 IC50 3.81 nM
COc1ccc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)nc1 CHEMBL3693853 IC50 4.0 nM
O=c1[nH]c(C2CCC2c2ncccn2)nc2c1cnn2C1CCC(F)(F)CC1 CHEMBL3961649 IC50 4.0 nM
O=c1[nH]c(C2CCC2c2ccccn2)nc2c1cnn2C1CCC(F)(F)CC1 CHEMBL3905237 IC50 4.0 nM
Cc1nc2ccccc2nc1OC1CN(C(C)c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)C1 CHEMBL3903464 IC50 4.56 nM
Cc1ncc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cn1 CHEMBL2179104 IC50 4.6 nM
C[C@@H]1CN(Cc2ccccc2F)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179098 IC50 4.6 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2nncc3ccccc23)C1 CHEMBL3896565 IC50 4.63 nM
C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179094 IC50 4.9 nM
O=c1[nH]c(CC2CCCCC2)nc2c1cnn2C1CCCC1 CHEMBL3661034 IC50 5.0 nM
COc1cncc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)c1 CHEMBL3693814 IC50 5.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccc(N3CCOCC3)nc2)nc2c1cnn2C1CCOCC1 CHEMBL3693817 IC50 5.0 nM
O=c1[nH]c(Cc2ccccc2-c2cnc(N3CCOCC3)nc2)nc2c1cnn2C1CCOCC1 CHEMBL3693825 IC50 5.0 nM
Cn1cc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cn1 CHEMBL3693826 IC50 5.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccccn2)nc2c1cnn2C1CCOCC1 CHEMBL3693833 IC50 5.0 nM
O=c1[nH]c(Cc2cc(Cl)ccc2-n2cccn2)nc2c1cnn2C1CCOCC1 CHEMBL3693849 IC50 5.0 nM
Cc1ccccc1-n1ncc2c(=O)[nH]c(CC3CCCC3)nc21 CHEMBL3671263 IC50 5.0 nM
Cc1nc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)oc1C CHEMBL4115313 IC50 5.0 nM
Cc1cnc([C@H]2CC[C@@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)nc1 CHEMBL3975883 IC50 5.0 nM
Cc1nnc([C@H]2CC[C@@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)s1 CHEMBL3940037 IC50 5.0 nM
Cc1ccc(OC2CN([C@@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cc1 CHEMBL3904471 IC50 5.37 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCC(Cl)CC1 CHEMBL5077120 IC50 5.4 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc3cccnc3n2)C1 CHEMBL3900728 IC50 5.41 nM
COc1ccc(NC(=O)CNc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 CHEMBL3360414 IC50 5.5 nM
O=c1[nH]c(CC2C=CCC2)nc2c1cnn2C1CCCC1 CHEMBL3661037 IC50 6.0 nM
N#Cc1ccc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cn1 CHEMBL3693815 IC50 6.0 nM
COc1cc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)ccn1 CHEMBL3693819 IC50 6.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccnc(F)c2)nc2c1cnn2C1CCOCC1 CHEMBL3693822 IC50 6.0 nM
O=c1[nH]c(Cc2ccccc2-c2cc[nH]n2)nc2c1cnn2C1CCOCC1 CHEMBL3693828 IC50 6.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccc(F)cn2)nc2c1cnn2C1CCOCC1 CHEMBL3693834 IC50 6.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CC1)COC2 CHEMBL5181099 IC50 6.0 nM
C[C@@H]1CN(Cc2ccccn2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179101 IC50 6.3 nM
COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)cc1 CHEMBL3360412 IC50 6.4 nM
CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3Nc3ncc(C(=O)O)c(C(F)(F)F)n3)nc12 CHEMBL466280 IC50 7.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ncccn2)C1 CHEMBL2180069 IC50 7.0 nM
Cc1nc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)no1 CHEMBL3693830 IC50 7.0 nM
Cc1ccn(-c2ccc(Cl)cc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)n1 CHEMBL3693851 IC50 7.0 nM
O=c1[nH]c(Cc2ccccc2-c2cccc(OC3CCC3)n2)nc2c1cnn2C1CCOCC1 CHEMBL3693852 IC50 7.0 nM
O=c1[nH]c([C@H]2CC[C@@H]2c2ncccn2)nc2c1cnn2C1CCC(F)(F)CC1 CHEMBL3984941 IC50 7.0 nM
O=c1[nH]c(C2CCC2c2ncccn2)nc2c1cnn2C1CCOCC1 CHEMBL3894454 IC50 7.0 nM
O=c1[nH]c(C2CCC2c2ccccn2)nc2c1cnn2C1CCOCC1 CHEMBL3945296 IC50 7.0 nM
O=c1[nH]c([C@@H]2CC[C@H]2c2ccccn2)nc2c1cnn2C1CCC(F)(F)CC1 CHEMBL4109040 IC50 7.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc(F)nc1 CHEMBL4644757 IC50 7.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CC2(CC(F)C2)C1 CHEMBL5075032 Ki 7.0 nM
Cc1cc(C)nc(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)n1 CHEMBL3976514 IC50 7.45 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ccc3ccccc3n2)C1 CHEMBL3963371 IC50 7.81 nM
COc1ncc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cn1 CHEMBL3693821 IC50 8.0 nM
Cc1ccc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)nc1 CHEMBL3693855 IC50 8.0 nM
O=C(c1cc2[nH]c(=O)c3cnc(C4CCCCC4)n3c2cc1Cl)N1CCN(CCO)CC1 CHEMBL3676173 IC50 8.0 nM
O=C(O)/C=C/c1ccc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n12 CHEMBL3676177 IC50 8.0 nM
CC(C)c1n[nH]c2c(=O)[nH]c(Cc3cccc(Cl)c3)nc12 CHEMBL512790 IC50 8.0 nM
COC(=O)c1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)s1 CHEMBL3932840 IC50 8.0 nM
C[C@H]1CN(Cc2ccc(/C=C/C(=O)NO)cc2)C[C@@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL5172893 IC50 8.0 nM
C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179105 IC50 8.0 nM
COc1ccc(NC(=O)[C@@H](CC(C)C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 CHEMBL3360417 IC50 8.1 nM
C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1cn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL4297290 IC50 8.19 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCC(F)(F)CC1 CHEMBL5071427 IC50 8.3 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CC[C@H](F)C1 CHEMBL4580164 IC50 8.7 nM
Cc1ccc(-c2c(C#N)c(=O)[nH]c3ccccc23)cc1 CHEMBL5415663 IC50 8.9 nM
O=c1[nH]c(Cc2ccccc2-c2ccc(OCc3ccccc3)nc2)nc2c1cnn2C1CCOCC1 CHEMBL3693820 IC50 9.0 nM
Cc1cccc(C2CN([C@H](C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)n1 CHEMBL3891006 IC50 9.33 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ncccn2)C1 CHEMBL3943305 IC50 9.49 nM
O=c1[nH]c(C(C2CC2)N2CC(Oc3ccccc3)C2)nc2c1cnn2C1CCOCC1 CHEMBL3912447 IC50 9.71 nM
CC(C)c1ncc2c(=O)[nH]c3cc(Cl)ccc3n12 CHEMBL3676168 IC50 10.0 nM
O=c1[nH]c(CN2CC(OCc3ccc(F)cc3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3964599 IC50 10.0 nM
CCCC1CCCc2c1[nH]c(=O)c(C#N)c2-c1ccc(C)cc1 CHEMBL5189429 IC50 10.0 nM
Cc1cc(C)nc(C2CN([C@H](C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)n1 CHEMBL3939685 IC50 10.5 nM
C[C@@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL2180064 IC50 10.5 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)cc2)C1 CHEMBL3928893 IC50 10.7 nM
Cc1cc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)no1 CHEMBL583064 pIC50 10.72 nM
Cc1ncc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cn1 CHEMBL578033 pIC50 10.96 nM
Cc1cc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)n(C)n1 CHEMBL575791 IC50 11.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL2180072 IC50 11.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccc(F)nc2)nc2c1cnn2C1CCOCC1 CHEMBL3693827 IC50 11.0 nM
Cc1ccn(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)n1 CHEMBL3693845 IC50 11.0 nM
O=c1[nH]c([C@@H]2CC[C@H]2c2ccccn2)nc2c1cnn2C1CCOCC1 CHEMBL4106640 IC50 11.0 nM
Cc1ccncc1-n1ncc2c(=O)[nH]c(C3CCC3c3ncccn3)nc21 CHEMBL3983420 IC50 11.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCSCC1 CHEMBL5077068 IC50 11.0 nM
C[C@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)c1ccc(Cl)cc1 CHEMBL5285855 IC50 11.0 nM
Cc1cc(C)nc(C2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)n1 CHEMBL3929841 IC50 11.5 nM
C[C@@H]1CN(Cc2cn3ccccc3n2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL566300 IC50 12.0 nM
Cc1cnc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cn1 CHEMBL2179103 IC50 12.0 nM
O=c1[nH]c(Cc2ccccc2-c2cccnc2)nc2c1cnn2C1CCOCC1 CHEMBL3693813 IC50 12.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccncc2)nc2c1cnn2C1CCOCC1 CHEMBL3693818 IC50 12.0 nM
O=c1[nH]c(Cc2ccccc2-c2cncnc2)cc2c1cnn2C1CCOCC1 CHEMBL3693824 IC50 12.0 nM
O=c1[nH]c(CC2CCCC2)nc2c1cnn2-c1cc(Cl)ccc1Cl CHEMBL3671262 IC50 12.0 nM
Cc1ccccc1-n1ncc2c(=O)[nH]c(C[C@H]3CCCC[C@@H]3O)nc21 CHEMBL3671264 IC50 12.0 nM
CC1CN(Cc2ccc(C(F)(F)F)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3968975 IC50 12.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCC(F)CC1 CHEMBL5082628 IC50 12.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL2180073 IC50 12.5 nM
Cc1nccc(C2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)n1 CHEMBL3915094 IC50 12.7 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Cc2cccc(F)c2)C1 CHEMBL3966125 IC50 12.7 nM
Cc1ccncc1-n1ncc2c(=O)[nH]c(CC3CCCC3)nc21 CHEMBL3671265 IC50 13.0 nM
Cc1nc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cs1 CHEMBL4113155 IC50 13.0 nM
CCN(CC)c1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3931022 IC50 13.0 nM
CC1CN(Cc2ccc(Cl)s2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3917950 IC50 13.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCSC1 CHEMBL4468399 IC50 13.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CCC2)CC1 CHEMBL5186852 IC50 13.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CCOC2)CC1 CHEMBL5207692 IC50 13.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Cc2ccccc2)C1 CHEMBL3986809 IC50 13.2 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C#N)c(Cl)c2)C1 CHEMBL2180066 IC50 13.2 nM
CCCC1CCCc2c(-c3ccc(C)cc3)nc(=O)[nH]c21 CHEMBL5174546 IC50 13.4 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ncc3ccccc3n2)C1 CHEMBL3938793 IC50 13.8 nM
COc1ccc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cc1 CHEMBL3693823 IC50 14.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CC2(CC(Cl)C2)C1 CHEMBL5080333 IC50 14.0 nM
CCN(C)C(=O)Oc1ccc(CNc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1OC CHEMBL5221005 IC50 14.0 nM
Cc1ccc(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)c(Cl)c1 CHEMBL3944744 IC50 14.2 nM
Cc1ccc(CC2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cn1 CHEMBL3986634 IC50 14.6 nM
Cc1cnc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cn1 CHEMBL575790 pIC50 14.79 nM
N#Cc1ccc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cc1 CHEMBL3693816 IC50 15.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CC[C@@H](N(C)C)C1 CHEMBL4515145 IC50 15.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CC1)CC2 CHEMBL5198935 IC50 15.0 nM
CCC[C@H]1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CC1)CC2 CHEMBL5306577 IC50 15.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2cccc(Cl)c2)C1 CHEMBL3909433 IC50 15.6 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccc3cnccc23)C1 CHEMBL3959518 IC50 15.6 nM
C[C@@H]1CN(Cc2ccc(C(F)(F)F)nc2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL574449 pIC50 15.85 nM
Cc1nnc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)s1 CHEMBL4115566 IC50 16.0 nM
CC(Nc1cc2c(cnn2C2CCCC2)c(=O)[nH]1)c1ccc(Cl)cc1 CHEMBL4212419 IC50 16.0 nM
CC(Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)c1ccc(Cl)cc1 CHEMBL4642517 IC50 16.0 nM
CCC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C)cc2)C1 CHEMBL3952273 IC50 16.5 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCOCC1 CHEMBL4544864 IC50 17.0 nM
COc1cc(CNc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)ccc1OC(=O)N(C)C CHEMBL5219813 IC50 17.0 nM
COc1ccc(OC2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cc1 CHEMBL3975963 IC50 17.2 nM
COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3CC(C)C)c(=O)[nH]2)cc1 CHEMBL3360420 IC50 17.6 nM
O=c1[nH]c(Cc2ccccc2-n2cccn2)nc2c1cnn2C1CCOCC1 CHEMBL3693829 IC50 18.0 nM
O=c1[nH]c(Cc2ccccc2-c2cccc(C(F)(F)F)n2)nc2c1cnn2C1CCOCC1 CHEMBL3693836 IC50 18.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ncc(C3CC3)cn2)C1 CHEMBL3894575 IC50 18.6 nM
CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3NC(=O)CC3CCOCC3)nc12 CHEMBL466680 IC50 19.0 nM
Cc1nc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)cs1 CHEMBL4111153 IC50 19.0 nM
CC1CN(Cc2ccc(OC(F)(F)F)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3972895 IC50 19.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)NC1CCCC1 CHEMBL4564974 IC50 19.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ncc(C3CC3)cn2)C1 CHEMBL3891813 IC50 19.8 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(C#N)c2)C1 CHEMBL2180067 IC50 20.0 nM
O=c1[nH]c(Cc2ccccc2-c2cccnn2)nc2c1cnn2C1CCOCC1 CHEMBL3693847 IC50 20.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccc(Cl)cn2)nc2c1cnn2C1CCOCC1 CHEMBL3693854 IC50 20.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CC[C@@H](F)C1 CHEMBL4450464 IC50 20.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2-c1ccc(C)cc1 CHEMBL5200395 IC50 20.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ncc(Cl)cn2)C1 CHEMBL3961243 IC50 20.2 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ncc3cccnc3n2)C1 CHEMBL3974065 IC50 20.2 nM
COc1ccc(NC(=O)C(C)Nc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)cc1 CHEMBL2178115 IC50 21.0 nM
Cc1ccc(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)o1 CHEMBL3693838 IC50 21.0 nM
O=c1[nH]c([C@@H]2CC[C@H]2c2csc(Cl)n2)nc2c1cnn2C1CCC(F)(F)CC1 CHEMBL4109531 IC50 21.0 nM
CC1CN(Cc2ccc(F)cc2Cl)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3951182 IC50 21.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccc(C#N)cc2)C1 CHEMBL3917822 IC50 21.1 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc3cccnc3c2)C1 CHEMBL3931904 IC50 21.4 nM
Cc1nccc(C2CN([C@H](C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)n1 CHEMBL3961018 IC50 21.9 nM
C[C@H](CC1=NC2C(C=NN2c2ccccc2Cl)C(=O)N1)C(F)(F)F CHEMBL1098370 IC50 22.0 nM
COc1ccc(C2CN([C@H](C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3909150 IC50 22.0 nM
Cc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)s1 CHEMBL3892261 IC50 22.0 nM
C[C@H](Cc1nc2c(cnn2-c2ccccc2Cl)c(=O)[nH]1)C(F)(F)F CHEMBL1513993 IC50 22.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCC(C#N)CC1 CHEMBL5083140 IC50 22.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccc(Cl)c2Cl)C1 CHEMBL3922328 IC50 22.3 nM
Cc1ccc(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cc1 CHEMBL3942507 IC50 22.5 nM
Cc1ccc(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)nn1 CHEMBL3987149 IC50 22.8 nM
Cc1ccc(N[C@@H]2CCCC[C@H]2Cc2nc3c(C(C)C)n[nH]c3c(=O)[nH]2)nn1 CHEMBL513304 IC50 23.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccc(C(F)(F)F)cn2)nc2c1cnn2C1CCOCC1 CHEMBL3693835 IC50 23.0 nM
O=c1[nH]c([C@@H]2CC[C@H]2c2ncco2)nc2c1cnn2C1CCOCC1 CHEMBL4114918 IC50 23.0 nM
O=c1[nH]c([C@@H]2CC[C@H]2c2ncccn2)nc2c1cnn2C1CCOCC1 CHEMBL4111436 IC50 23.0 nM
CC1CN(Cc2ccc(F)c(F)c2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3946166 IC50 23.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CCCC2)CC1 CHEMBL5181856 IC50 23.0 nM
Cc1cc(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)ccc1Cl CHEMBL3924737 IC50 23.3 nM
O=c1[nH]c(Cc2ccccc2-n2cc(C(F)(F)F)cn2)nc2c1cnn2C1CCOCC1 CHEMBL3693843 IC50 24.0 nM
CC1CN(Cc2ccc3nccnc3c2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3967919 IC50 24.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)NC1CCOC1 CHEMBL4436823 IC50 24.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCCC(C(F)(F)F)C1 CHEMBL5076716 IC50 24.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccc(C#N)c2)C1 CHEMBL3920726 IC50 24.1 nM
COc1cccc(OC2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)c1 CHEMBL3967393 IC50 24.3 nM
CCC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL3892802 IC50 24.5 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccc(C#N)cc2)C1 CHEMBL3927513 IC50 24.8 nM
Cc1cnc(C2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)nc1 CHEMBL3953753 IC50 25.0 nM
CC1CN(Cc2ccco2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3903903 IC50 25.0 nM
CC1CN(Cc2cncc(F)c2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3912671 IC50 25.0 nM
Cc1ccc(-c2c3c([nH]c(=O)c2C#N)C(CC(C)C)CCC3)cc1 CHEMBL5174386 IC50 25.0 nM
C[C@@H](NC(=O)CCCC[C@H]1CCSS1)c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL5267538 IC50 25.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ccccc2)C1 CHEMBL3981854 IC50 25.4 nM
Cc1ccnc(C2CN([C@H](C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)n1 CHEMBL3976128 IC50 25.8 nM
COc1ccc(NC(=O)CNc2nc3c(cnn3C(C)C)c(=O)[nH]2)cc1 CHEMBL3360418 IC50 25.9 nM
O=c1[nH]c(Cc2ccccc2-c2cc(C(F)(F)F)ccn2)nc2c1cnn2C1CCOCC1 CHEMBL3693837 IC50 26.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCOC(C)(C)C1 CHEMBL5083709 IC50 26.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCN(C)CC1 CHEMBL5094231 IC50 26.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccnnc2)nc2c1cnn2C1CCOCC1 CHEMBL3693840 IC50 27.0 nM
CC1CN(Cc2ccc(N(C)C)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3914442 IC50 27.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccccn2)C1 CHEMBL3941515 IC50 27.2 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2cccnc2)C1 CHEMBL3898369 IC50 27.4 nM
Cc1ncn(-c2ccccc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)n1 CHEMBL3693842 IC50 28.0 nM
Cc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)o1 CHEMBL3890242 IC50 28.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Cc2cncnc2)C1 CHEMBL3954822 IC50 28.2 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccccc2C#N)C1 CHEMBL3964206 IC50 28.3 nM
COc1ccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cn1 CHEMBL575775 pIC50 28.84 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2cccnc2)C1 CHEMBL3953546 IC50 28.9 nM
CC[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2cccc(C)n2)C1 CHEMBL3973466 IC50 29.8 nM
CCC(C)Cc1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL3661036 IC50 30.0 nM
CCC(C)Cc1nc2c(cnn2-c2cnccc2C)c(=O)[nH]1 CHEMBL3671267 IC50 30.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(Cl)c2C#N)C1 CHEMBL3982088 IC50 30.1 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cc(Cl)ccc2Cl)C1 CHEMBL3978170 IC50 30.9 nM
O=c1[nH]c(Cc2cc(C(F)(F)F)ccc2-n2cccn2)nc2c1cnn2C1CCOCC1 CHEMBL3693850 IC50 31.0 nM
Cc1coc([C@H]2CC[C@@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)n1 CHEMBL3941861 IC50 31.0 nM
Cc1ccncc1-n1ncc2c(=O)[nH]c([C@@H]3CC[C@H]3c3nc(C)c(C)s3)nc21 CHEMBL4113262 IC50 31.0 nM
Cc1cnc(C2CN([C@H](C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)nc1 CHEMBL3951069 IC50 31.2 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ccccn2)C1 CHEMBL3926879 IC50 31.9 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ncccn2)C1 CHEMBL2180070 IC50 32.0 nM
Cc1ccnc(C2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)n1 CHEMBL3980448 IC50 32.0 nM
O=c1[nH]c(C(c2ccccc2)N2CC(Oc3ccccc3)C2)nc2c1cnn2C1CCOCC1 CHEMBL3956035 IC50 32.0 nM
Cc1ccncc1-n1ncc2c(=O)[nH]c([C@@H]3CC[C@H]3c3ncccn3)nc21 CHEMBL4112667 IC50 32.0 nM
CC1CN(Cc2ccc(Cl)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3919678 IC50 32.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ncccn2)C1 CHEMBL3936084 IC50 32.4 nM
COc1cc(F)cc(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)c1 CHEMBL3929843 IC50 32.4 nM
CC[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ncc(Cl)cn2)C1 CHEMBL3983960 IC50 32.5 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C#N)cc2F)C1 CHEMBL3950583 IC50 33.2 nM
O=c1[nH]c(Cc2ccccc2-n2cccc2)nc2c1cnn2C1CCOCC1 CHEMBL3693846 IC50 34.0 nM
COc1ccc(CN[C@H](C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)c(O)c1 CHEMBL4547969 IC50 34.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ccncn2)C1 CHEMBL3975054 IC50 34.3 nM
COc1ccc(Cl)c(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)c1 CHEMBL3921722 IC50 34.4 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Cc2ccccc2)C1 CHEMBL3977354 IC50 34.8 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C#N)c(F)c2)C1 CHEMBL2180065 IC50 34.8 nM
CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3Nc3ncccn3)nc12 CHEMBL466481 IC50 35.0 nM
CCCCC1CCCc2c1[nH]c(=O)c(C#N)c2-c1ccc(C)cc1 CHEMBL5205423 IC50 35.0 nM
CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3NC(=O)CN3CCCC3)nc12 CHEMBL466475 IC50 36.0 nM
CC1CN(Cc2ccc(N(C)C)nc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3937695 IC50 36.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(C#N)c2Cl)C1 CHEMBL3903920 IC50 36.2 nM
CC1CN(Cc2cccnc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3963563 IC50 37.0 nM
C[C@H](c1nc2c(cnn2C2CCC2)c(=O)[nH]1)N1CC(Oc2ncccn2)C1 CHEMBL3913192 IC50 37.3 nM
O=c1[nH]c(Cc2ccccc2-n2ccc(C(F)(F)F)n2)nc2c1cnn2C1CCOCC1 CHEMBL3693844 IC50 38.0 nM
Cc1cccc(-n2ncc3c(=O)[nH]c(CC4CCCC4)nc32)c1C CHEMBL3671261 IC50 38.0 nM
COC1CCN(C(=O)[C@@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)CC1 CHEMBL5092549 IC50 38.0 nM
Cc1cccc(CN2C[C@@H](C)[C@H](c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)c1 CHEMBL575745 pIC50 38.02 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cnccn2)C1 CHEMBL3939155 IC50 39.9 nM
C[C@@H]1CN(Cc2ccc(C(=O)NO)cc2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL5205841 IC50 40.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2cnccn2)C1 CHEMBL3940649 IC50 40.4 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cc(F)cc(F)c2)C1 CHEMBL3966828 IC50 40.4 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccnc3cc(Cl)ccc23)C1 CHEMBL3909415 IC50 40.4 nM
CC(C)c1n[nH]c2c(=O)[nH]c(Cc3ccccc3OCCN3CCOCC3)nc12 CHEMBL466068 IC50 41.0 nM
O=c1[nH]c(Cc2ccccc2-c2noc(C(F)(F)F)n2)nc2c1cnn2C1CCOCC1 CHEMBL3693848 IC50 41.0 nM
COc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)c(Cl)c1 CHEMBL3929310 IC50 41.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCCOCC1 CHEMBL5073242 IC50 41.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ccncc2)C1 CHEMBL3961293 IC50 41.8 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2cccnn2)C1 CHEMBL3957437 IC50 41.9 nM
CC(C)c1ncc2c(=O)[nH]c3cc(C(=O)N(C)C)ccc3n12 CHEMBL3676169 IC50 42.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2cccnc2)C1 CHEMBL3976412 IC50 42.4 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C#N)cc2Cl)C1 CHEMBL3899668 IC50 42.6 nM
Cc1ccc(OC2CN(C(C)c3nc4c(cnn4C(C)C)c(=O)[nH]3)C2)cc1 CHEMBL3902728 IC50 42.9 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ncccn2)C1 CHEMBL3972576 IC50 43.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccc(C(F)(F)F)c2)C1 CHEMBL3973062 IC50 43.6 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2cncnc2)C1 CHEMBL3895691 IC50 43.7 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(Cl)cc2C#N)C1 CHEMBL3953361 IC50 44.7 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccc(Cl)c2F)C1 CHEMBL3925832 IC50 44.9 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL2180071 IC50 45.0 nM
O=c1[nH]c(Cc2ccccc2-n2cncn2)nc2c1cnn2C1CCOCC1 CHEMBL3693841 IC50 45.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC(C)(C)CC1 CHEMBL5182115 IC50 45.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ncccn2)C1 CHEMBL2180068 IC50 45.3 nM
CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3NC(=O)NCCCN3CCOCC3)nc12 CHEMBL466480 IC50 46.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccc(C(F)(F)F)cc2)C1 CHEMBL3912141 IC50 47.0 nM
Cc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3942448 IC50 47.0 nM
COc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3981635 IC50 47.0 nM
C[C@H]1CN(Cc2ccc(F)cc2F)C[C@@H]1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3893383 IC50 47.0 nM
Cc1ccc(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)c(F)c1F CHEMBL3932652 IC50 47.2 nM
CC1CN(Cc2ccc(F)cc2F)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3922812 IC50 48.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(F)c2Cl)C1 CHEMBL3939164 IC50 48.8 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccc(OC(F)(F)F)c2)C1 CHEMBL3971685 IC50 48.9 nM
COc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3938287 IC50 49.0 nM
CC(Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCOCC1 CHEMBL5079421 IC50 49.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)cc2)C1 CHEMBL2180074 IC50 50.0 nM
O=c1[nH]c(C2CN(Cc3ccccc3)CC2C(F)(F)F)nn2c(C3CCOCC3)ncc12 CHEMBL3962722 IC50 50.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ccccn2)C1 CHEMBL3937332 IC50 50.3 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(F)(Cc2ccccc2)C1 CHEMBL3977865 IC50 50.3 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cc(F)c(F)c(F)c2)C1 CHEMBL3968948 IC50 51.4 nM
CC[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ncc(C)cn2)C1 CHEMBL3926936 IC50 51.8 nM
Cc1ccc(NC(=O)C(C)Nc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)cc1 CHEMBL2178114 IC50 52.0 nM
COc1ccc(NC(=O)CNc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)cc1 CHEMBL3360411 IC50 52.0 nM
CC1CN(Cc2ccncc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3910352 IC50 52.0 nM
O=c1[nH]c(Cc2ccccn2)nc2c1cnn2C1CCOCC1 CHEMBL4206492 IC50 52.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccccc2Cl)C1 CHEMBL3915870 IC50 52.1 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCCCC1 CHEMBL5079692 IC50 53.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2cccc(C(=O)NC3CCC3)c2)C1 CHEMBL3960917 IC50 53.3 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ccncc2)C1 CHEMBL3911892 IC50 53.9 nM
COC1CN(Cc2ccccc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3918968 IC50 54.0 nM
O=c1[nH]c(Cc2ccccc2-c2ccco2)nc2c1cnn2C1CCOCC1 CHEMBL3693839 IC50 55.0 nM
C[C@@H](Cc1cc2c(cnn2-c2ccccc2Cl)c(=O)[nH]1)C(F)(F)F CHEMBL4209805 IC50 55.0 nM
C[C@@H](Cc1nc2c(cnn2-c2ccccc2Cl)c(=O)[nH]1)C(F)(F)F CHEMBL4636079 IC50 55.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Cc2cccc(F)c2)C1 CHEMBL3910997 IC50 55.5 nM
CC(C)c1n[nH]c2c(=O)[nH]c(Cc3ccccc3OC(F)(F)F)nc12 CHEMBL467282 IC50 56.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)c1ccc(Cl)cc1 CHEMBL4644938 IC50 56.0 nM
C[C@@H](NC(=O)/C=C/c1cccc(O)c1)c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL5277578 IC50 56.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cc(F)ccc2F)C1 CHEMBL2180075 IC50 57.0 nM
CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(Oc2ccc(F)cc2)C1 CHEMBL3912515 IC50 57.0 nM
C[C@@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Cc2ccc(C(=O)Nc3ccccc3N)cc2)C1 CHEMBL5206074 IC50 57.0 nM
Cc1cccc(OC2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)c1 CHEMBL3981256 IC50 57.2 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc3ccccc3n2)C1 CHEMBL3899259 IC50 57.2 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cc(F)ccc2F)C1 CHEMBL3966971 IC50 57.4 nM
Cc1cnc([C@H]2CC[C@@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)o1 CHEMBL3967929 IC50 58.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc3ccncc3c2)C1 CHEMBL3904858 IC50 58.3 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccncn2)C1 CHEMBL3953992 IC50 59.4 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2cccnn2)C1 CHEMBL3923541 IC50 59.6 nM
CC(Cc1nc2c(cnn2-c2ccccc2Cl)c(=O)[nH]1)C(F)(F)F CHEMBL3671266 IC50 60.0 nM
Cc1nc([C@H]2CC[C@@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)oc1C CHEMBL3929324 IC50 60.0 nM
CCC1CCCc2c1[nH]c(=O)c(C#N)c2-c1ccc(C)cc1 CHEMBL5186538 IC50 60.0 nM
CC1CN(Cc2ccc(N3CCCC3)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3902442 IC50 61.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)cc2)C1 CHEMBL3915839 IC50 61.2 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2cccc(Br)n2)C1 CHEMBL3963310 IC50 61.7 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC2(CC(=O)c3ccccc3O2)C1 CHEMBL3913110 IC50 61.7 nM
CC1CN(Cc2c(F)cccc2F)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3958102 IC50 62.0 nM
C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL572747 IC50 63.0 nM
CC1CN(Cc2ccc(Cl)o2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3914708 IC50 63.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2cncnc2)C1 CHEMBL3978870 IC50 63.3 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(Cl)c2)C1 CHEMBL3942586 IC50 63.8 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(Cl)c2)C1 CHEMBL2177496 IC50 64.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cc(F)c(F)cc2Cl)C1 CHEMBL3976689 IC50 64.6 nM
CCC(CC)n1ncc2c(=O)[nH]c(CC3C=CCC3)nc21 CHEMBL3661038 IC50 65.0 nM
C[C@@H]1CN(Cc2ccc(F)cc2)C[C@@]1(F)c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL4280847 IC50 65.0 nM
CC(C)n1ncc2c(=O)[nH]c([C@@H]3CN(Cc4ccccc4)C[C@H]3C)nc21 CHEMBL572517 IC50 66.0 nM
CC[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ccccn2)C1 CHEMBL3924201 IC50 66.0 nM
COc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cn1 CHEMBL3935864 IC50 67.0 nM
Cc1ccc(OC2CN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)cc1 CHEMBL3907231 IC50 67.1 nM
COc1ccc(CC2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3966717 IC50 68.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)cc2C#N)C1 CHEMBL3985333 IC50 69.4 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C#N)cc2)C1 CHEMBL2177497 IC50 70.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c3c2OCC3)C1 CHEMBL3918059 IC50 70.1 nM
COc1cccc(C2CCN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)c1OC CHEMBL3930242 IC50 72.9 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)cc2Cl)C1 CHEMBL3900850 IC50 74.5 nM
Cc1c(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)ccc(F)c1F CHEMBL3977149 IC50 78.7 nM
Nc1nc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)cs1 CHEMBL4108377 IC50 80.0 nM
O=c1[nH]c(CN2CC(Oc3ccc(F)cc3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3969402 IC50 80.0 nM
CC(c1nc2c(cnn2C(C)C)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL3952535 IC50 81.7 nM
CC(C)c1n[nH]c2c(=O)[nH]c(Cc3ccccc3OCc3ccccc3)nc12 CHEMBL511564 IC50 82.0 nM
COc1ccc(OCC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3971935 IC50 82.0 nM
COc1ccc(CN2CC(OC)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3926347 IC50 83.0 nM
Cc1cc(Cl)ccc1OC1CN(C(C)c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)C1 CHEMBL3911695 IC50 84.5 nM
Cc1ccncc1-n1ncc2c(=O)[nH]c([C@H]3CC[C@@H]3c3nc(C)c(C)o3)nc21 CHEMBL3979555 IC50 85.0 nM
CCOC1CCCc2c1[nH]c(=O)c(C#N)c2-c1ccc(C)cc1 CHEMBL5185089 IC50 85.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Cc2ncccn2)C1 CHEMBL3943258 IC50 85.1 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccc(Cl)c2)C1 CHEMBL3970823 IC50 85.6 nM
O=c1[nH]c(CC2CCCO2)nc2c1cnn2C1CCCC1 CHEMBL3661039 IC50 86.0 nM
CC1CN(Cc2ccc(C(F)(F)F)nc2)CC1c1nn2c(-c3ccc(F)cc3)ncc2c(=O)[nH]1 CHEMBL3957944 IC50 86.0 nM
CN(C)c1ccc(C2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3969487 IC50 86.0 nM
CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(N(C)C)cc2)C1 CHEMBL3950526 IC50 86.0 nM
Cc1ccnc(C2CN([C@H](C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)c1 CHEMBL3961611 IC50 86.6 nM
CC(C)c1n[nH]c2c(=O)[nH]c(C[C@@H]3CCCC[C@H]3OCCN3CCOCC3)nc12 CHEMBL513129 IC50 87.0 nM
C[C@@H](CC1=NC2C(C=NN2c2ccccc2Cl)C(=O)N1)C(F)(F)F CHEMBL1094374 IC50 88.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CC[C@H](N(C)C)C1 CHEMBL4465401 IC50 88.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(Cl)cc2)C1 CHEMBL3905517 IC50 88.2 nM
C[C@@H]1CNC[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179097 IC50 89.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CC1)CC2(F)F CHEMBL5178038 IC50 89.0 nM
C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(O)(Cc2ccccc2)C1 CHEMBL3927088 IC50 89.2 nM
COC1CN(Cc2ccc(C)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3958057 IC50 90.0 nM
Cc1ccc(F)c(OC2CN(C(C)c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)c1 CHEMBL3960539 IC50 90.8 nM
Cc1ccc(OC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3934013 IC50 91.0 nM
CC1CCCN1C(=O)[C@@H](C)Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL4457086 IC50 91.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2c(F)cccc2Cl)C1 CHEMBL3979081 IC50 91.1 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC(C#N)CC1 CHEMBL5192598 IC50 92.0 nM
COC1CN(Cc2ccc(F)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3895738 IC50 94.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(Cl)cc2F)C1 CHEMBL3907869 IC50 99.1 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCC(F)(F)C1 CHEMBL4445082 IC50 100.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CC2)C(F)(F)C1 CHEMBL5169869 IC50 100.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cc(F)c(F)cc2F)C1 CHEMBL3910651 IC50 102.0 nM
COC1CCN(C(=O)[C@@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C1 CHEMBL4435082 IC50 103.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C(F)(F)F)cc2)C1 CHEMBL3909407 IC50 107.0 nM
C[C@H]1CN(Cc2ccc(C(=O)NO)cc2)C[C@@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL5205968 IC50 107.0 nM
CCC(CC)n1ncc2c(=O)[nH]c(CC3CCCCC3)nc21 CHEMBL3661035 IC50 110.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(F)c2F)C1 CHEMBL3915635 IC50 110.0 nM
Cc1ccc(OC2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3949396 IC50 110.0 nM
CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(N3CCCC3)cc2)C1 CHEMBL3940758 IC50 110.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2c(F)cccc2F)C1 CHEMBL3962226 IC50 112.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N1CCCC1 CHEMBL4543521 IC50 112.0 nM
Cc1ccc(F)cc1OC1CN(C(C)c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)C1 CHEMBL3938028 IC50 119.0 nM
CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(O)cc2)C1 CHEMBL3967025 IC50 120.0 nM
O=c1[nH]c(CN2CC(c3ncc(N4CCCC4)cn3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3945195 IC50 120.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)c(F)c2)C1 CHEMBL3938958 IC50 125.0 nM
CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(F)cc2)C1 CHEMBL3925133 IC50 128.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)CCN1CCOCC1 CHEMBL5084713 IC50 128.0 nM
Cc1ccc(-c2c3c([nH]c(=O)c2C#N)C(C(C)C)CCC3)cc1 CHEMBL5188899 IC50 130.0 nM
CC(C)c1ccc(OC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3910728 IC50 134.0 nM
CC1CN(Cc2cncnc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3896450 IC50 135.0 nM
CC[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC[C@H](c2ccccc2)C1 CHEMBL3900225 IC50 136.0 nM
Cc1ccc(-c2c3c([nH]c(=O)c2C#N)C(CC(F)(F)F)CCC3)cc1 CHEMBL5187864 IC50 140.0 nM
COc1ccccc1OC1CCN([C@H](C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C1 CHEMBL2177504 IC50 148.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccccc2Cl)C1 CHEMBL3932377 IC50 148.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccccc2F)C1 CHEMBL3938077 IC50 148.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)C(=O)N1CCOCC1 CHEMBL5079367 IC50 148.0 nM
CC(C)Cn1ncc2c(=O)[nH]c([C@@H]3CN(Cc4ccccc4)C[C@H]3C)nc21 CHEMBL576952 IC50 150.0 nM
Cc1ccc(COC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3961416 IC50 150.0 nM
COc1ccc(OC)c(C2CCN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)c1 CHEMBL3955281 IC50 151.0 nM
C[C@H]1CN(Cc2ccccc2)C[C@@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL2179095 IC50 152.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2cc(F)ccc2Cl)C1 CHEMBL3935055 IC50 153.0 nM
O=c1[nH]c(CN2CC(Oc3ccccc3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3963269 IC50 153.0 nM
CC(C)n1ncc2c(=O)[nH]c(N[C@H](C)C(=O)N3CCOCC3)nc21 CHEMBL5078451 IC50 153.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2cccc(Cl)c2)C1 CHEMBL3893703 IC50 155.0 nM
O=c1[nH]c(CN2CC(Oc3c(F)cccc3F)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3932319 IC50 155.0 nM
O=c1[nH]c(CN2CC(Oc3ccc(OC(F)(F)F)cc3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3906994 IC50 158.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC[C@@H](Oc2ncccn2)C1 CHEMBL3904055 IC50 169.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccncc2)C1 CHEMBL3931721 IC50 174.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ncccn2)C1 CHEMBL3945951 IC50 180.0 nM
Cc1cnc(CN2C[C@@H](C)[C@](F)(c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cn1 CHEMBL4284260 IC50 180.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccc(Cl)cc2)C1 CHEMBL3936188 IC50 184.0 nM
C[C@@H]1CN(Cc2ccccn2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL582856 pIC50 194.98 nM
C[C@@H]1CN(Cc2ncccn2)C[C@@]1(F)c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL4292094 IC50 200.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC(C)CC1 CHEMBL5206771 IC50 200.0 nM
CC1CN(Cc2ccccc2)CC1c1nn2c(-c3ccc(F)cc3F)ncc2c(=O)[nH]1 CHEMBL3965399 IC50 201.0 nM
CSc1ccc(NC(=O)C(C)Nc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)cc1 CHEMBL2178120 IC50 204.0 nM
O=c1[nH]c(CN2CC(c3ccccc3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3897083 IC50 208.0 nM
CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(OC(F)(F)F)cc2)C1 CHEMBL3891872 IC50 210.0 nM
Cc1ncc(CN2C[C@@H](C)[C@](F)(c3nc4c(cnn4C4CCOCC4)c(=O)[nH]3)C2)cn1 CHEMBL4284696 IC50 210.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC[C@H](c2ccccc2)C1 CHEMBL3902959 IC50 211.0 nM
COc1ccccc1O[C@@H]1CCN(C(C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C1 CHEMBL3935091 IC50 211.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(F)cc2F)C1 CHEMBL3912117 IC50 211.0 nM
Cc1cccc(Cl)c1OC1CN(C(C)c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)C1 CHEMBL3962280 IC50 215.0 nM
COc1ccccc1[C@H]1CCN([C@H](C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C1 CHEMBL3914026 IC50 216.0 nM
CCC(c1nc2c(cnn2C(C)C)c(=O)[nH]1)N1CC(Oc2ccc(C)cc2)C1 CHEMBL3941851 IC50 216.0 nM
C[C@@H]1CN(Cc2ccccn2)C[C@@]1(F)c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 CHEMBL4287650 IC50 220.0 nM
Cc1ccc(-c2c3c([nH]c(=O)c2C#N)C(C)CCC3)cc1 CHEMBL5172996 IC50 220.0 nM
CCN(C)C(=O)[C@@H](C)Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1 CHEMBL4537603 IC50 227.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccccc2)C1 CHEMBL2177503 IC50 230.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccccc2)C1 CHEMBL3958240 IC50 230.0 nM
CN(C)c1nc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)cs1 CHEMBL4108585 IC50 233.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccc(C(C)(C)C)cc2)C1 CHEMBL3965709 IC50 234.0 nM
COc1cccc(NC(=O)C(C)Nc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)c1 CHEMBL2178118 IC50 237.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC[C@H](Oc2ncccn2)C1 CHEMBL3979884 IC50 237.0 nM
COc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1F CHEMBL3976164 IC50 240.0 nM
Cc1nnc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)o1 CHEMBL4113790 IC50 242.0 nM
CCC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2ccccn2)C1 CHEMBL3938048 IC50 245.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2cc(Cl)ccc2Cl)C1 CHEMBL3962034 IC50 248.0 nM
CCC(c1nc2c(cnn2C(C)C)c(=O)[nH]1)N1CC(Oc2ccccc2)C1 CHEMBL3940786 IC50 256.0 nM
CC1CN(Cc2ccccc2)CC1c1nn2c(C3=CCOCC3)ncc2c(=O)[nH]1 CHEMBL3950556 IC50 281.0 nM
CCOc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3967660 IC50 290.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1C[C@@H]2C(=O)Nc3ccccc3[C@@H]2C1 CHEMBL3898960 IC50 292.0 nM
C[C@@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC[C@@H](Oc2ccccc2Cl)C1 CHEMBL3931173 IC50 292.0 nM
COc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)c(F)c1 CHEMBL3938072 IC50 300.0 nM
COc1ccccc1NC(=O)C(C)Nc1nc2c(cnn2-c2ccccc2Cl)c(=O)[nH]1 CHEMBL2178119 IC50 308.0 nM
CC(c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(Oc2cccnc2)C1 CHEMBL3912972 IC50 310.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccccc2Cl)C1 CHEMBL3945333 IC50 321.0 nM
COc1ccc(C2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 CHEMBL3922636 IC50 327.0 nM
CC1(C)CCN(c2c(C#N)c(=O)[nH]c3cccnc23)CC1 CHEMBL5184687 IC50 330.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccc(C(=O)N(C)C)cc2)C1 CHEMBL3929787 IC50 332.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2cccc(C(F)(F)F)c2)C1 CHEMBL3931322 IC50 335.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC[C@@H](Oc2ccccc2C#N)C1 CHEMBL3943350 IC50 336.0 nM
C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nn2c(-c3ccc(F)cc3)ncc2c(=O)[nH]1 CHEMBL3919986 IC50 341.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2cccc(Cl)c2)C1 CHEMBL3928967 IC50 350.0 nM
O=c1[nH]c(CN2CC(Oc3cccnc3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3903616 IC50 350.0 nM
CC(C)=C[C@H]1Oc2cc(O)ccc2-c2oc3c4c(cc(O)c3c(=O)c21)OC(C)(C)C=C4 CHEMBL4168752 IC50 350.0 nM
CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccccc2)C1 CHEMBL3943470 IC50 360.0 nM
COc1ccc(CN2CC(C)C(c3nn4c(-c5ccc(F)cc5)ncc4c(=O)[nH]3)C2)cn1 CHEMBL3981133 IC50 372.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccncc2)C1 CHEMBL3974517 IC50 382.0 nM
O=c1[nH]c(COCc2ccccc2)nn2c(C3CCOCC3)ncc12 CHEMBL3902338 IC50 384.0 nM
CCC(CC)n1ncc2c(=S)[nH]c(CC3CCCCC3)nc21 CHEMBL3661040 IC50 390.0 nM
CC1CN(CC2CCCCC2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 CHEMBL3980663 IC50 409.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccc(F)cc2)C1 CHEMBL3900369 IC50 410.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2-c1cc(CC)no1 CHEMBL5200754 IC50 410.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2-c1ccc(C#N)cc1 CHEMBL5182074 IC50 430.0 nM
O=c1[nH]c([C@@H]2CC[C@H]2c2nnco2)nc2c1cnn2C1CCC(F)(F)CC1 CHEMBL4111950 IC50 433.0 nM
Cc1cc([C@@H]2CC[C@H]2c2nc3c(cnn3C3CCC(F)(F)CC3)c(=O)[nH]2)on1 CHEMBL4113869 IC50 450.0 nM
CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12 CHEMBL1520 IC50 460.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC(c2ccccc2F)C1 CHEMBL3897582 IC50 517.0 nM
CC(C)c1nn(C)c2c(=O)[nH]c(Cc3ccccc3OCCN3CCOCC3)nc12 CHEMBL466474 IC50 530.0 nM
Cc1ccc(-c2c3c([nH]c(=O)c2C#N)CCCC3)cc1 CHEMBL5173800 IC50 530.0 nM
O=c1[nH]c(CN2CC(c3ccc(C(F)(F)F)cn3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3904838 IC50 560.0 nM
O=c1[nH]c(CN2CC(c3ccc(F)cc3)C2)nn2c(C3CCOCC3)ncc12 CHEMBL3934796 IC50 563.0 nM
COc1cccc(C2(C)CCN([C@H](C)c3nc4c(cnn4C4CCCC4)c(=O)[nH]3)C2)c1 CHEMBL3935625 IC50 568.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2-c1ccc(CC)cn1 CHEMBL5175292 IC50 570.0 nM
CC(C)CN1C[C@@H](C)[C@](F)(c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)C1 CHEMBL4291070 IC50 590.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC1 CHEMBL2177500 IC50 593.0 nM
CC(c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CCC1 CHEMBL3955603 IC50 593.0 nM
C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)N(C)C CHEMBL4453141 IC50 594.0 nM
CC(C)Oc1ccc(NC(=O)C(C)Nc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)cc1 CHEMBL2178117 IC50 595.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2-c1ncc(CC)s1 CHEMBL5182499 IC50 600.0 nM
CCc1ccnc2c(N3CCC(C)(C)CC3)c(C#N)c(=O)[nH]c12 CHEMBL5177802 IC50 610.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2-c1ccc(C)nc1 CHEMBL5181294 IC50 630.0 nM
CCCC1CNCc2c1[nH]c(=O)c(C#N)c2-c1ccncc1 CHEMBL5194476 IC50 640.0 nM
CC1CN(Cc2ccccc2)CC1c1nn2c(-c3cccnc3)ncc2c(=O)[nH]1 CHEMBL3932149 IC50 656.0 nM
Cc1ccccc1O[C@@H]1CCN([C@H](C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C1 CHEMBL3890909 IC50 661.0 nM
COC(=O)[C@H]1CN([C@H](C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C[C@@H]1c1ccc(F)cc1 CHEMBL3904758 IC50 693.0 nM
CCOc1ccc(NC(=O)C(C)Nc2nc3c(cnn3-c3ccccc3Cl)c(=O)[nH]2)cc1 CHEMBL2178116 IC50 696.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(Oc2ccc(C(F)(F)F)cc2)C1 CHEMBL3936724 IC50 713.0 nM
CC(Nc1nc2c(cnn2-c2ccccc2Cl)c(=O)[nH]1)C(=O)Nc1ccccc1 CHEMBL2178113 IC50 721.0 nM
Cc1ccc(-c2c(C#N)c(=O)[nH]c3cccnc23)cc1 CHEMBL5182009 IC50 725.0 nM
CC(C)CN1C[C@@H](C)[C@H](c2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)C1 CHEMBL4277017 IC50 750.0 nM
C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1C[C@@H]2C(=O)Nc3ccc(Cl)cc3[C@@H]2C1 CHEMBL3905777 IC50 763.0 nM
Cc1ncc(CN2CC(c3nc4c(cnn4C4CCOCC4)c(=O)n3C)[C@H](C)C2)cn1 CHEMBL4276756 IC50 850.0 nM
C[C@@H](c1ccc(C(F)(F)F)cc1)n1nc(CF)c2c(=O)[nH]c(O)nc21 CHEMBL4212952 IC50 899.0 nM
CO[C@@H]1CN([C@H](C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C[C@H]1c1ccccc1 CHEMBL3954761 IC50 913.0 nM
COc1ccccc1O[C@H]1CCN([C@H](C)c2nc3c(cnn3C3CCCC3)c(=O)[nH]2)C1 CHEMBL3978438 IC50 915.0 nM